2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T41e,Highlights across studies: - **Atopic march ML model:** Simplified models using routine early-life clinical features accurately predicted moderate-to-severe persistent asthma/allergic rhinitis by ages 5–11. - **Peanut OIT (IMPACT follow-up):** 80% of children who received pnOIT only (group A, n=40) were eating peanut at follow-up; 35% of group A reported peanut reactions since IMPACT; IgG4:IgE ratio remained higher in the pnOIT group vs. placebo years later. - **Dupilumab & autoimmunity in children:** Cutaneous autoimmune diagnoses (mainly psoriasis and alopecia areata) were ~2 per 1,000 children/year higher in the dupilumab group; no significant differences in endocrine, GI, or rheumatologic autoimmune diagnoses. - **EoE transcriptome:** Dupilumab normalized >1,300 dysregulated EoE genes (eosinophil and non-eosinophil pathways) across all age groups, sustained on treatment. - **α-Gal IgG & atherosclerosis:** Anti-α-Gal IgG formed immune complexes with α-Gal–bearing LDL, enhancing macrophage uptake and foam cell formation in vitro.31:T5e5,Airway hyper-responsiveness (AHR) is well established in asthma but remains under-recognized in chronic obstructive pulmonary disease (COPD). The recognition of COPD heterogeneity, particularly eosinophilic COPD and asthma COPD overlap, has increased interest in AHR as a clinical marker of type 2 (T2) inflammation. This phenotype is present in 20% to 40% of patients with COPD and has become a focus of clinical trials exploring biologics targeting IL-4, IL-5, IL-13, and thymic stromal lymphopoietin. We aim to review current evidence on AHR in COPD, its relationship with inflammatory phenotypes, diagnostic modalities, and therapeutic implications. AHR in COPD reflects both structural and inflammatory mechanisms. Direct challenges such as methacholine predominantly assess airway geometry, whereas indirect challenges such as mannitol reflect more activity of T2 inflammation and correlates consequently with eosinophils and fractional exhaled nitric oxide. Patients with AHR may derive greater benefit from inhaled corticosteroids than AHR-negative patients. Although AHR reduction has been demonstrated with biologics in asthma, no study has evaluated their effects on AHR in COPD. AHR represents a clinically relevant and promising treatable trait in COPD, particularly in T2-high phenotypes. Standardized challenges combined with the integration of inflammatory markers and targeted trials of biologics are needed to clarify its role in personalized COPD management and therapeutic decision-making.32:T611,This scoping review aimed to explore psychological and related biopsychosocial factors influencing adherence to biologic therapies among individuals with asthma. Despite the proven efficacy of biologics for severe type 2 inflammation, real-world adherence remains variable. The review sought to identify individual, clinical, and contextual determinants that facilitate or hinder adherence behaviors. A systematic search of PubMed, Scopus, and APA PsycINFO identified 14 studies published between 2018 and 2025. Most were observational or retrospective and conducted in the United States. Adherence rates were generally moderate to high but varied across biologics. Systemic barriers included high out-of-pocket costs, complex insurance procedures, and limited access to specialist care. Clinically, patients with milder symptoms or low perceived treatment benefit were more likely to discontinue. Psychological barriers-such as fear of injections, illness denial, depression, and stigma-were recurrent yet understudied. Facilitators included perceived efficacy, emotional reassurance, shared decision-making, and supportive treatment settings. Adherence to biologic therapies in asthma reflects a multidimensional interplay between systemic, clinical, and psychological influences. Integrating psychological assessment, patient education, and system-level support is essential to sustain long-term engagement. Future research should address psychological mechanisms and develop tailored interventions to enhance adherence and improve clinical outcomes.33:T808,Abstract Purpose of Review This scoping review aimed to explore psychological and related biopsychosocial factors influencing adherence to biologic therapies among individuals with asthma. Despite the proven efficacy of biologics for severe type 2 inflammation, real-world adherence remains variable. The review sought to identify individual, clinical, and contextual determinants that facilitate or hinder adherence behaviors. Recent Findings A systematic search of PubMed, Scopus, and APA PsycINFO identified 14 studies published between 2018 and 2025. Most were observational or retrospective and conducted in the United States. Adherence rates were generally moderate to high but varied across biologics. Systemic barriers included high out-of-pocket costs, complex insurance procedures, and limited access to specialist care. Clinically, patients with milder symptoms or low perceived treatment benefit were more likely to discontinue. Psychological barriers—such as fear of injections, illness denial, depression, and stigma—were recurrent yet understudied. Facilitators included perceived efficacy, emotional reassurance, shared decision-making, and supportive treatment settings. Summary Adherence to biologic therapies in asthma reflects a multidimensional interplay between systemic, clinical, and psychological influences. Integrating psychological assessment, patient education, and system-level support is essential to sustain long-term engagement. Future research should address psychological mechanisms and develop tailored interventions to enhance adherence and improve clinical outcomes. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Biologic in Allergy: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed Allergy papers on Biologic (modality). Clinician-written summaries and practical action steps. 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Biologics targeting IL-4, IL-5, IL-13, IL-31, TSLP, and IgE have transformed management of T2-driven diseases, but sustained suppression of these pathways raises unresolved questions about long-term homeostatic consequences.","limitations":"Narrative review without systematic search or meta-analysis; causal claims about evolutionary co-evolution are inferential; long-term safety data on T2 pathway blockade are not yet available.","practice_takeaway":"Clinicians using T2-targeting biologics should be aware that these pathways also serve protective homeostatic roles; long-term follow-up for consequences of sustained T2 suppression (e.g., infection susceptibility, barrier health, microbiome shifts) is warranted. An expanding set of T2-driven diseases beyond classic allergy may benefit from these targeted agents."}},{"doi":"10.1111/all.70466","pmid":"42618976","title":"Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations","journal_title":"Allergy","journal_issn":"0105-4538","published_at":"2026-08-19T00:00:00.000Z","url":"https://doi.org/10.1111/all.70466","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-30T06:19:56.216Z","updated_at":"2026-08-30T06:19:56.216Z","tags":[{"paper_doi":"10.1111/all.70466","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Acute Generalized Exanthematous Pustulosis","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Anaphylaxis","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Drug Hypersensitivity","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Drug Reaction with Eosinophilia and Systemic Symptoms","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Maculopapular Exanthema","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Stevens-Johnson Syndrome","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"condition","value":"Toxic Epidermal Necrolysis","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Anesthetic","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Antibiotic","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Biologic","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Chemotherapy","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Contrast Media","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"modality","value":"Proton Pump Inhibitor","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"study_design","value":"Clinical Practice Guideline","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"warning","value":"Chemotherapy-specific guidance (testing within 2 weeks) differs from the general 4–6 week window; clinicians should apply the correct algorithm per drug class.","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"warning","value":"Level of evidence assigned as '3' (consensus guideline/expert panel); the paper does not report an original trial with a defined sample size, so no sample_size tag was applied.","value_numeric":null},{"paper_doi":"10.1111/all.70466","tag_type":"warning","value":"Many drug-class recommendations are 'conditional' due to sparse negative-control data, meaning specificity for those agents is not firmly established.","value_numeric":null}],"summaries":{"what_studied":"Updated EAACI guidelines standardizing skin testing methodology (prick, intradermal, patch) for immediate and non-immediate drug hypersensitivity reactions, including validated non-irritant concentrations for major drug classes and risk-stratified algorithms for drug provocation testing.","key_result":"The optimal testing window is 4–6 weeks post-reaction for immediate reactions (false negatives rise beyond 6 months); the validated intradermal test threshold is a wheal ≥ initial wheal +3 mm at 20 min after injecting exactly 0.02 mL. Risk algorithms now allow direct drug provocation for mild maculopapular exanthema, while anaphylaxis requires prior skin testing; skin tests are deemed safe and useful for DRESS/AGEP/SJS/TEN.","limitations":"Conditional recommendations are provided for many drug classes where few or no negative controls are available, limiting specificity data. Crushing tablets and diluting at 30% in petrolatum introduces significant variability in final active-ingredient concentrations.","practice_takeaway":"Test patients for immediate drug hypersensitivity 4–6 weeks post-reaction using the standardized 0.02 mL intradermal technique (wheal ≥ initial +3 mm = positive). For mild maculopapular exanthema, skin tests can be bypassed in favor of direct drug provocation, but anaphylaxis or severe cutaneous reactions (DRESS/AGEP/SJS/TEN) require skin testing first."}},{"doi":"10.1016/j.jaci.2026.06.010","pmid":null,"title":"The Editors’ Choice","journal_title":"Journal of Allergy and Clinical Immunology","journal_issn":"0091-6749","published_at":"2026-08-05T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaci.2026.06.010","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-08-11T13:26:12.518Z","updated_at":"2026-08-24T06:18:18.582Z","tags":[{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"brand","value":"Dupixent","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Allergic Rhinitis","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Alpha-Gal Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Asthma","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Atherosclerosis","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Atopic Dermatitis","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Chronic Rhinosinusitis With Nasal Polyps","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Eosinophilic Esophagitis","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"condition","value":"Peanut Allergy","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"generic","value":"dupilumab","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"modality","value":"Biologic","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"modality","value":"Machine Learning / Predictive Modeling","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"modality","value":"Oral Immunotherapy","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"sample_size","value":"n=10000","value_numeric":10000},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"study_design","value":"Editorial / Editors' Choice (Multi-Study Summary)","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"Level of evidence reflects the strongest individual study design cited (validated ML cohort study / long-term RCT follow-up); other highlighted studies range from cross-sectional to in vitro mechanistic.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"Only a publisher landing/navigation page was provided — no abstract, methods, results, or conclusions are accessible. The paper title is 'The Editors' Choice,' which is likely a curated editorial or highlights section rather than an original research article. No structured content, study design, population, or outcomes could be extracted. Full text access is required to generate meaningful summaries or tags.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The IMPACT peanut OIT follow-up had a 54% participation rate, which may affect generalizability of long-term outcomes.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The paper provided contains only a DOI, URL, journal name, and publication date — no abstract, methods, results, or any other substantive content. Structured summaries and tags cannot be generated without source text. Please provide the full text or abstract of the article for accurate extraction.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The paper provided contains only metadata (DOI, URL, journal, and publication date) with no abstract, body text, or results. No clinical content could be extracted. Please provide the full text or abstract to generate meaningful summaries and tags.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The paper provided contains only metadata (title, DOI, journal, and publication date) with no abstract, methods, results, or discussion. No structured summary, tags, or evidence-based content can be extracted. Please provide the full paper text to enable meaningful analysis.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The provided source text contains only metadata (DOI, URL, journal name, and publication date) with no abstract, body text, methods, results, or conclusions. Structured summaries and tags cannot be extracted without substantive content. The paper is titled 'The Editors' Choice,' which is typically an editorial or curated highlight piece — its specific focus, population, intervention, and results are entirely unknown from the information provided.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The provided source text contains only metadata (DOI, URL, journal name, and publication date) with no abstract, body text, or results. All summary fields and tags have been left null or empty because no content can be extracted or inferred without speculating. Please provide the full paper text for a complete structured extraction.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The title 'The Editors' Choice' is a generic editorial section label, not a specific study title. It is unclear which article(s) or topic(s) are being referenced.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"The α-Gal/foam cell findings are in vitro only; clinical cardiovascular implications should not be overstated.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.010","tag_type":"warning","value":"This is an Editors' Choice summary article covering six distinct original studies, not a single primary study — tags and sample sizes reflect the most prominent individual studies cited, not a single pooled population.","value_numeric":null}],"summaries":{"what_studied":"This Editors' Choice issue highlights six original studies covering: (1) ML-based prediction of the atopic march in >10,000 children with early-onset atopic dermatitis; (2) CD25 as a marker of activated MCTCs in chronic rhinosinusitis with nasal polyps; (3) long-term follow-up (~8–11 years) of the IMPACT peanut oral immunotherapy trial in children aged 1–3 years; (4) rates of new autoimmune diagnoses in children ages 6–17 with atopic disease on vs. off dupilumab (PEDSnet, 10 sites, 4-year follow-up); (5) dupilumab's effect on the EoE transcriptome across pediatric, adolescent, and adult patients; and (6) anti-α-Gal IgG antibodies as a mechanistic link between α-Gal sensitization and atherosclerosis.","key_result":"$30","limitations":"- The atopic march ML study and dupilumab/autoimmunity study are both EHR-based and observational, limiting causal inference and subject to coding/ascertainment bias.\n- The IMPACT long-term follow-up enrolled only 78 of 146 original participants (54%), introducing potential selection bias.\n- The α-Gal/atherosclerosis mechanism was demonstrated in vitro only; in vivo cardiovascular relevance remains unproven.","practice_takeaway":"Early-life clinical features (respiratory symptoms, allergy meds, sensitization) can be used to flag young children with eczema for closer monitoring before asthma develops. Children on dupilumab should continue standard longitudinal monitoring for cutaneous autoimmune conditions such as psoriasis and alopecia areata, while being reassured that systemic autoimmune risks appear low."}},{"doi":"10.1016/j.jaci.2026.06.012","pmid":"42379525","title":"Dupilumab outcomes in pediatric asthma by early eosinophil status: Post hoc analysis of VOYAGE/EXCURSION","journal_title":"Journal of Allergy and Clinical Immunology","journal_issn":"0091-6749","published_at":"2026-06-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaci.2026.06.012","source_score":8,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-07T06:30:44.195Z","updated_at":"2026-09-07T06:30:44.195Z","tags":[{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"brand","value":"Dupixent","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"condition","value":"Eosinophilia","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"condition","value":"Pediatric Asthma","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"condition","value":"Type 2 Asthma","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"generic","value":"dupilumab","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"modality","value":"Biologic","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"modality","value":"IL-4/IL-13 Inhibitor","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"sample_size","value":"n=156","value_numeric":156},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"study_design","value":"Post Hoc Analysis of Randomized Controlled Trial with Open-Label Extension","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"warning","value":"Level of evidence is rated 3 due to the post hoc and open-label extension design, despite originating from an RCT (VOYAGE).","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"warning","value":"The early eosinophil increase subgroup was small (n=35, 22.4% of 156), limiting statistical power for safety and efficacy comparisons.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"warning","value":"The impact_flag 'safety_signal' is used here in a reassuring direction — the signal is the absence of harm from transient eosinophilia, not a new adverse finding.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.06.012","tag_type":"warning","value":"This is a post hoc subgroup analysis; results should be interpreted as hypothesis-generating rather than confirmatory.","value_numeric":null}],"summaries":{"what_studied":"This post hoc analysis of the VOYAGE RCT and EXCURSION open-label extension evaluated long-term dupilumab efficacy and safety in children aged 6–11 with type 2 asthma, specifically in subgroups with and without early blood eosinophil increases (baseline <500 cells/μL rising to ≥500 cells/μL by week 12), over up to 2 years.","key_result":"At VOYAGE week 12, 22.4% (35/156) of dupilumab-treated children had an early eosinophil increase (≥500 cells/μL). Dupilumab reduced severe exacerbation rates vs. placebo in both subgroups, with sustained improvements in FEV1, ACQ-5-IA score, FeNO, and total IgE — and no safety differences observed between subgroups.","limitations":"Post hoc subgroup analysis limits causal inference; sample sizes within subgroups (especially early eosinophil increase group, n=35) are small; open-label extension design introduces potential bias.","practice_takeaway":"Clinicians can reassure families that early transient eosinophil rises on dupilumab do not appear to affect efficacy or safety outcomes in children with type 2 asthma. 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quantified.","value_numeric":null}],"summaries":{"what_studied":"A review of airway hyper-responsiveness (AHR) in COPD, its links to type 2 inflammation, diagnostic challenge tests (methacholine vs mannitol), and therapeutic implications.","key_result":"A T2-high phenotype is present in 20%–40% of COPD; indirect AHR testing with mannitol aligns with eosinophils and FeNO, AHR-positive patients may benefit more from inhaled corticosteroids than AHR-negative patients, and no study has tested biologics’ effects on AHR in COPD.","limitations":"This is a review without new primary data or quantified treatment effects. No COPD trials have measured AHR outcomes with biologics, and AHR testing lacks standardized protocols.","practice_takeaway":"Consider AHR a treatable trait in COPD, particularly in T2-high phenotypes. AHR-positive patients may gain more from inhaled corticosteroids than AHR-negative patients; biologics have not yet been studied for AHR outcomes in COPD."}},{"doi":"10.1080/02770903.2025.2610346","pmid":"41454879","title":"Real-world clinical experience with benralizumab for severe eosinophilic asthma in the Czech Republic: fewer corticosteroids and better symptom control","journal_title":"Journal of Asthma","journal_issn":"0277-0903","published_at":"2025-12-27T00:00:00.000Z","url":"https://doi.org/10.1080/02770903.2025.2610346","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-01","doi":"10.1080/02770903.2025.2610346","days":"14","issn":"0277-0903","rank":"9","field":"Clinical Medicine","score":"2","category":"Allergy","categories":["Allergy"],"_categories":["Allergy"]},"pubmed":{"doi":"10.1080/02770903.2025.2610346","title":"Real-world clinical experience with benralizumab for severe eosinophilic asthma in the Czech Republic: fewer corticosteroids and better symptom control.","journal":"The Journal of asthma : official journal of the Association for the Care of Asthma","methods":"","results":"Patients in the Czech cohort (","abstract":"Benralizumab suppresses type 2 inflammation and improves outcomes of patients with severe eosinophilic asthma (SEA). We investigated real-life clinical experience with this biological therapy in Czechia to provide evidence on effectiveness in the context of the local healthcare system.\nWe have analyzed data from the Czech cohort participating in the multi-national observational study BREEZE covering 12 months before the first benralizumab dose and 56 wk after that. Eligibility included the diagnosis of SEA and at least one dose of benralizumab administered in clinical practice. Descriptive statistics were used, and changes from baseline were assessed using paired t-test or Wilcoxon signed-rank test.\nPatients in the Czech cohort (\nClinically meaningful benefits of benralizumab treatment were confirmed in the Czech cohort, especially reduction of mOCS need, decrease of exacerbations, and improvement of asthma control.","keywords":["Biological therapy","asthma control","effectiveness","exacerbation rate","maintenance oral corticosteroids","observational study"],"pubmed_id":"41454879","conclusions":"Clinically meaningful benefits of benralizumab treatment were confirmed in the Czech cohort, especially reduction of mOCS need, decrease of exacerbations, and improvement of asthma 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