2f:I[703058,["/_next/static/immutable/chunks/2esyeua7r8hxb.js","/_next/static/immutable/chunks/43wzqu_q6b8co.js","/_next/static/immutable/chunks/02igegklyi312.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/3d54cr_x61503.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/41sb2pnxui1_7.js","/_next/static/immutable/chunks/0z5fu495o1bws.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T611,This scoping review aimed to explore psychological and related biopsychosocial factors influencing adherence to biologic therapies among individuals with asthma. Despite the proven efficacy of biologics for severe type 2 inflammation, real-world adherence remains variable. The review sought to identify individual, clinical, and contextual determinants that facilitate or hinder adherence behaviors. A systematic search of PubMed, Scopus, and APA PsycINFO identified 14 studies published between 2018 and 2025. Most were observational or retrospective and conducted in the United States. Adherence rates were generally moderate to high but varied across biologics. Systemic barriers included high out-of-pocket costs, complex insurance procedures, and limited access to specialist care. Clinically, patients with milder symptoms or low perceived treatment benefit were more likely to discontinue. Psychological barriers-such as fear of injections, illness denial, depression, and stigma-were recurrent yet understudied. Facilitators included perceived efficacy, emotional reassurance, shared decision-making, and supportive treatment settings. Adherence to biologic therapies in asthma reflects a multidimensional interplay between systemic, clinical, and psychological influences. Integrating psychological assessment, patient education, and system-level support is essential to sustain long-term engagement. Future research should address psychological mechanisms and develop tailored interventions to enhance adherence and improve clinical outcomes.31:T808,Abstract Purpose of Review This scoping review aimed to explore psychological and related biopsychosocial factors influencing adherence to biologic therapies among individuals with asthma. Despite the proven efficacy of biologics for severe type 2 inflammation, real-world adherence remains variable. The review sought to identify individual, clinical, and contextual determinants that facilitate or hinder adherence behaviors. Recent Findings A systematic search of PubMed, Scopus, and APA PsycINFO identified 14 studies published between 2018 and 2025. Most were observational or retrospective and conducted in the United States. Adherence rates were generally moderate to high but varied across biologics. Systemic barriers included high out-of-pocket costs, complex insurance procedures, and limited access to specialist care. Clinically, patients with milder symptoms or low perceived treatment benefit were more likely to discontinue. Psychological barriers—such as fear of injections, illness denial, depression, and stigma—were recurrent yet understudied. Facilitators included perceived efficacy, emotional reassurance, shared decision-making, and supportive treatment settings. Summary Adherence to biologic therapies in asthma reflects a multidimensional interplay between systemic, clinical, and psychological influences. Integrating psychological assessment, patient education, and system-level support is essential to sustain long-term engagement. Future research should address psychological mechanisms and develop tailored interventions to enhance adherence and improve clinical outcomes. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Scoping Review in Allergy: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed Allergy papers on Scoping Review (study design). Clinician-written summaries and practical action steps. 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clinicians should interpret diet–eczema associations cautiously.","value_numeric":null},{"paper_doi":"10.1111/all.70429","tag_type":"warning","value":"Impact flag 'practice_changing' applied because the review consolidates recommendations across allergen introduction, dietary diversity, and responsive feeding — clinicians should note this is a scoping review and not a meta-analysis.","value_numeric":null},{"paper_doi":"10.1111/all.70429","tag_type":"warning","value":"Level of evidence set to 2 based on scoping review of systematic reviews; some may consider this lower given the scoping (rather than systematic) design without meta-analysis.","value_numeric":null},{"paper_doi":"10.1111/all.70429","tag_type":"warning","value":"The sample_size tag reflects the number of included systematic reviews (n=108), not individual participants — total participant count is not reported in the abstract.","value_numeric":null}],"summaries":{"what_studied":"This EAACI scoping review mapped evidence linking complementary feeding practices (diet diversity, dietary patterns, allergen introduction timing, macronutrients, micronutrients, and ultra-processed foods) to immune outcomes, allergy, infection, and growth in infants and toddlers ≤3 years, searching MEDLINE and Epistemonikos from inception to November 2024.","key_result":"From 13,512 screened records, 108 systematic reviews were included; key findings: greater diet diversity reduced asthma and food allergy risk; early allergen introduction lowered food allergy incidence; responsive feeding was linked to healthier growth and lower obesity risk; Western-style diets correlated with higher allergy risk; iron, zinc, and vitamin D supplementation reduced infection and anemia risk but had mixed effects on allergy.","limitations":"Scoping review design maps evidence but does not pool effect sizes or assess causality. Evidence gaps exist for diet diversity, ultra-processed foods, and plant-based diets. Heterogeneity in definitions across studies limits direct comparison.","practice_takeaway":"Encourage dietary diversity and timely introduction of allergenic foods in the first year of life while discouraging restrictive feeding practices and ultra-processed foods. Micronutrient supplementation (iron, zinc, vitamin D) can reduce infection and anemia risk, but clinicians should not expect consistent allergy benefits."}},{"doi":"10.1016/j.waojou.2026.101395","pmid":null,"title":"Pediatric IgE mediated food allergies and ethnic group inequalities: A scoping review","journal_title":"World Allergy Organization Journal","journal_issn":"1939-4551","published_at":"2026-05-14T00:00:00.000Z","url":"https://doi.org/10.1016/j.waojou.2026.101395","source_score":3,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-05-19T13:22:52.046Z","updated_at":"2026-05-19T13:22:52.046Z","tags":[{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"condition","value":"IgE-Mediated Food Allergy","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"study_design","value":"Scoping Review","value_numeric":null},{"paper_doi":"10.1016/j.waojou.2026.101395","tag_type":"warning","value":"Full paper text was not provided — only bibliographic metadata was available. 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79% continued the same biologic ≥6 months, primary adherence was 84.9%, and discontinuation reached 29.8% in one study; home/hybrid delivery showed higher median PDC than clinic (0.83 vs 0.75).","limitations":"Heterogeneous designs, populations, and adherence measures limited comparability; most data were U.S.-centric; psychological factors were often secondary and undermeasured; no formal risk-of-bias assessment was performed.","practice_takeaway":"Assess and address depression, needle fear, illness denial, and stigma; use shared decision-making and patient education; mitigate system barriers (costs, authorizations) and consider home or less-frequent dosing models, which were linked to better adherence in some studies."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"category","value":"Allergy"},{"tag_type":"study_design","value":"Scoping Review"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Allergy","href":"/hub/Allergy"},{"name":"study design: Scoping Review","metadata":{"type":"study_design","value":"Scoping Review"}}],"hrefConfig":{"basePath":"/hub/Allergy/papers","webViewQueryParams":{"hub_ctx":"category_tag","hub_category":"Allergy","hub_tag_type":"study_design","hub_tag_value":"Scoping Review"}}}]]

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