36:I[703058,["/_next/static/immutable/chunks/355lxm8rh3fxr.js","/_next/static/immutable/chunks/0yecwcl2vsgzm.js","/_next/static/immutable/chunks/33s6yl_7t575t.js","/_next/static/immutable/chunks/2sgwc-d-l730j.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/34zte87e1oxbr.js","/_next/static/immutable/chunks/3o8_7x7kr1gqd.js","/_next/static/immutable/chunks/3gndzt6n9hhhz.js","/_next/static/immutable/chunks/368brjxhfaune.js","/_next/static/immutable/chunks/2-7hs63mi7grl.js","/_next/static/immutable/chunks/1xa6orki-joi9.js","/_next/static/immutable/chunks/316o2u2mp21uq.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0g9dls0-elfj5.js"],"PaperListPageClient"] 35:T431,{"@context":"https://schema.org","@type":"CollectionPage","name":"Dual GIP/GLP-1 Receptor Agonist in Cardiac & Cardiovascular Systems: Research & Clinical Takeaways","description":"Explore peer-reviewed Cardiac & Cardiovascular Systems papers on Dual GIP/GLP-1 Receptor Agonist (modality). Clinician-written summaries and practical action steps. Updated daily.","url":"https://www.reachrx.ai/hub/Cardiac%20%26%20Cardiovascular%20Systems/modality/Dual%20GIP%2FGLP-1%20Receptor%20Agonist","breadcrumb":{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.reachrx.ai"},{"@type":"ListItem","position":2,"name":"Research Hub","item":"https://www.reachrx.ai/hub"},{"@type":"ListItem","position":3,"name":"Cardiac & Cardiovascular Systems","item":"https://www.reachrx.ai/hub/Cardiac%20%26%20Cardiovascular%20Systems"},{"@type":"ListItem","position":4,"name":"Dual GIP/GLP-1 Receptor Agonist","item":"https://www.reachrx.ai/hub/Cardiac%20%26%20Cardiovascular%20Systems/modality/Dual%20GIP%2FGLP-1%20Receptor%20Agonist"}]}}37:T4dc,There is growing clinical interest in strategies for improving clinical outcomes in patients with heart failure (HF) and obesity. The development of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and of the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA has expanded therapeutic options for this population. This expert consensus provides a comprehensive and pragmatic framework for the use of GLP-1 RAs and GIP/GLP-1 RA in patients with HF, focusing on clinical integration, patient selection, safety, and tolerability. We review the evidence supporting their use in patients with HF with preserved ejection fraction (HFpEF), where clinical trials have demonstrated meaningful reductions in body weight alongside improvements in health status and exercise capacity. Whether these effects translate into fewer HF events or lower cardiovascular mortality remains uncertain, as current evidence is limited to two small trials with few observed events. In contrast, data regarding the efficacy and safety of these drugs in HF with reduced ejection fraction are scarce, with dedicated outcome trials yet to be launched. Finally, this document highlights knowledge gaps and outlines future research directions in this field.38:T4fb,There is growing clinical interest in strategies for improving clinical outcomes in patients with heart failure (HF) and obesity. The development of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and of the dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 RA has expanded therapeutic options for this population. This expert consensus provides a comprehensive and pragmatic framework for the use of GLP‐1 RAs and GIP/GLP‐1 RA in patients with HF, focusing on clinical integration, patient selection, safety, and tolerability. We review the evidence supporting their use in patients with HF with preserved ejection fraction (HFpEF), where clinical trials have demonstrated meaningful reductions in body weight alongside improvements in health status and exercise capacity. Whether these effects translate into fewer HF events or lower cardiovascular mortality remains uncertain, as current evidence is limited to two small trials with few observed events. In contrast, data regarding the efficacy and safety of these drugs in HF with reduced ejection fraction are scarce, with dedicated outcome trials yet to be launched. Finally, this document highlights knowledge gaps and outlines future research directions in this field.22:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$35"}}]],["$","$L36",null,{"title":"Dual GIP/GLP-1 Receptor Agonist in Cardiac & Cardiovascular Systems: Research & Clinical Takeaways","description":"Review Cardiac & Cardiovascular Systems evidence by treatment modality: Dual GIP/GLP-1 Receptor Agonist — concise summaries and practical next steps.","papers":[{"doi":"10.1002/ejhf.70082","pmid":"41309245","title":"Pharmacological treatment for patients with obesity and heart failure: Focus on glucagon‐like peptide‐1 receptor agonists.\n \n European Journal of Heart Failure\n \n expert consensus document","journal_title":"European Journal of Heart Failure","journal_issn":"1388-9842","published_at":"2025-11-28T00:00:00.000Z","url":"https://doi.org/10.1002/ejhf.70082","source_score":38,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-01","doi":"10.1002/ejhf.70082","days":"7","issn":"1388-9842","rank":"3","field":"Clinical Medicine","score":"38","category":"Cardiac & Cardiovascular Systems","categories":["Cardiac & Cardiovascular Systems"],"_categories":["Cardiac & Cardiovascular Systems"]},"pubmed":{"doi":"10.1002/ejhf.70082","title":"Pharmacological treatment for patients with obesity and heart failure: Focus on glucagon-like peptide-1 receptor agonists. 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Iliescu’ Bucharest Romania"},{"name":"University of Medicine Carol Davila Bucharest Romania"}]},{"given":"Seif","family":"El Hadidi","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons in Ireland (RCSI) Dublin Ireland"}]},{"given":"Thomas M.","family":"Gorter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen University Medical Centre Groningen Groningen The Netherlands"}]},{"given":"Riccardo M.","family":"Inciardi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health University of Brescia Brescia Italy"}]},{"given":"Mark C.","family":"Petrie","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow Glasgow UK"}]},{"given":"Gabriele G.","family":"Schiattarella","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC) Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin Germany"},{"name":"Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany"},{"name":"Friede Springer Cardiovascular Prevention Center at Charité – Universitätsmedizin Berlin Berlin Germany"},{"name":"Experimental and Clinical Research Center (ECRC), a Cooperation of Charité‐Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC) Berlin Germany"}]},{"given":"Davide","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Södersjukhuset; Karolinska Institutet Stockholm Sweden"},{"name":"Cardiology, Cardiothoracic Department, Azienda Sanitaria 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Consensus","value_numeric":null},{"paper_doi":"10.1002/ejhf.70082","tag_type":"warning","value":"Effects on heart failure events and cardiovascular mortality remain uncertain and are based on two small HFpEF trials with few events.","value_numeric":null},{"paper_doi":"10.1002/ejhf.70082","tag_type":"warning","value":"Evidence in HFrEF is sparse, and dedicated outcome trials had not launched at the time of publication.","value_numeric":null},{"paper_doi":"10.1002/ejhf.70082","tag_type":"warning","value":"Summary is based on an expert consensus abstract; quantitative effect sizes and trial sample sizes are not reported.","value_numeric":null}],"summaries":{"what_studied":"An expert consensus outlines practical use of GLP-1 receptor agonists and the dual GIP/GLP-1 agonist for patients with heart failure and obesity, emphasizing HFpEF, patient selection, safety, tolerability, and clinical integration.","key_result":"In HFpEF, trials reported weight loss and improvements in health status and exercise capacity, but effects on heart failure events and cardiovascular mortality are unknown because evidence comes from two small trials with few events. Data for HFrEF are scarce, and dedicated outcome trials have not yet launched.","limitations":"Findings for HFpEF rely on two small trials with few observed events. There is a lack of dedicated outcome trials, and evidence in HFrEF is minimal.","practice_takeaway":"GLP-1–based therapy can aid weight loss and symptom improvement in HFpEF with obesity, but event and mortality benefits are unproven. In HFrEF, evidence is insufficient; use these agents with careful attention to safety and tolerability while awaiting outcomes data."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"category","value":"Cardiac & Cardiovascular Systems"},{"tag_type":"modality","value":"Dual GIP/GLP-1 Receptor Agonist"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Cardiac & Cardiovascular Systems","href":"/hub/Cardiac%20%26%20Cardiovascular%20Systems"},{"name":"Dual GIP/GLP-1 Receptor Agonist"}],"hrefConfig":{"basePath":"/hub/Cardiac%20%26%20Cardiovascular%20Systems/papers","webViewQueryParams":{"hub_ctx":"category_tag","hub_category":"Cardiac & Cardiovascular Systems","hub_tag_type":"modality","hub_tag_value":"Dual GIP/GLP-1 Receptor Agonist"}}}]]

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