2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T9e5,The cardiovascular impact of biologics used in psoriasis is not fully understood. Several studies have suggested that the inhibition of the T-helper 17 cell pathway could lead to the destabilization of atherosclerotic plaques, leading to major adverse cardiovascular events (MACEs). To assess whether the initiation of interleukin (IL)-17(R)A inhibitors triggers MACEs. In this case-time-control study using the French National Health Insurance database, all individuals who received IL-17(R)A inhibitors (secukinumab, ixekizumab, and brodalumab) from 2016 to 2021, were included and classified according to their cardiovascular risk level. The risk period was defined as the 6 months before the MACE, and the reference period as the 6 months before the risk period. The same design for patients who received tumor necrosis factor (TNF)-α inhibitors (adalimumab or etanercept) for similar indications (psoriasis, psoriatic arthritis, ankylosing spondylitis, or juvenile arthritis), as an active comparator. The data analysis was conducted between April 2023 and August 2024. The initiation of the biologic was screened in both periods. The odds ratios (ORs) for the risk of MACEs were assessed following the initiation of IL-17(R)A inhibitors and TNF-α inhibitors independently. Subsequently, the OR for the risk of MACE associated with IL-17(R)A inhibitors was estimated using TNF-α inhibitors as the comparator. Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk (P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change. In this case-time-control study based on a national insurance database, there was no evidence of a significant association between MACEs and the initiation of IL-17(R)A inhibitors, regardless of the individual cardiovascular risk of the patient. However, a modest risk increase cannot be entirely excluded.31:Tf24, Importance The cardiovascular impact of biologics used in psoriasis is not fully understood. Several studies have suggested that the inhibition of the T-helper 17 cell pathway could lead to the destabilization of atherosclerotic plaques, leading to major adverse cardiovascular events (MACEs). Objective To assess whether the initiation of interleukin (IL)-17(R)A inhibitors triggers MACEs. Design, Setting, and Participants In this case–time-control study using the French National Health Insurance database, all individuals who received IL-17(R)A inhibitors (secukinumab, ixekizumab, and brodalumab) from 2016 to 2021, were included and classified according to their cardiovascular risk level. The risk period was defined as the 6 months before the MACE, and the reference period as the 6 months before the risk period. The same design for patients who received tumor necrosis factor (TNF)–α inhibitors (adalimumab or etanercept) for similar indications (psoriasis, psoriatic arthritis, ankylosing spondylitis, or juvenile arthritis), as an active comparator. The data analysis was conducted between April 2023 and August 2024. Exposure The initiation of the biologic was screened in both periods. Main Outcomes and Measures The odds ratios (ORs) for the risk of MACEs were assessed following the initiation of IL-17(R)A inhibitors and TNF-α inhibitors independently. Subsequently, the OR for the risk of MACE associated with IL-17(R)A inhibitors was estimated using TNF-α inhibitors as the comparator. Results Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk ( P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change. Conclusions In this case–time-control study based on a national insurance database, there was no evidence of a significant association between MACEs and the initiation of IL-17(R)A inhibitors, regardless of the individual cardiovascular risk of the patient. However, a modest risk increase cannot be entirely excluded. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Taltz in Dermatology: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed Dermatology papers on Taltz (brand). Clinician-written summaries and practical action steps. 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no meta-analysis was conducted due to methodological heterogeneity.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0797","tag_type":"warning","value":"Sex tag set to 'female' as the primary dataset covers maternal exposure; paternal exposure studies also exist but are a small subset (3 studies, 281 pregnancies).","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0797","tag_type":"warning","value":"The review included all indications for IL inhibitors (not psoriasis-only), so findings may not be fully generalizable to psoriasis patients specifically.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0797","tag_type":"warning","value":"The sample size (n=5,962) reflects maternal pregnancy exposures across all included studies, not a single trial cohort; the majority originated from pharmacovigilance databases with inherent reporting bias.","value_numeric":null}],"summaries":{"what_studied":"A PRISMA-compliant systematic literature review (search date May 2026) evaluated the reproductive safety of IL-12/23, IL-17, and IL-23 inhibitors during pregnancy and with paternal exposure in patients with psoriasis, examining pregnancy and neonatal outcomes across all available study designs.","key_result":"49 publications met inclusion criteria, reporting 5,962 pregnancies with maternal exposure; ustekinumab had the most data (2,933 pregnancies), followed by secukinumab (1,877), risankizumab (589), ixekizumab (296), guselkumab (217), tildrakizumab (32), bimekizumab (11), brodalumab (6), and mirikizumab (1). Cohort-level findings were generally reassuring — no consistent signal for adverse pregnancy or neonatal outcomes — except one study reporting increased risk of small-for-gestational-age infants with ustekinumab. Paternal exposure data were very limited (3 studies, 281 pregnancies).","limitations":"- Most exposures (n=5,074) came from pharmacovigilance databases that capture only adverse events, making incidence rates incalculable and meta-analysis infeasible.\n- Critical confounders (disease activity, exposure timing, comedications) were missing or unreported in the majority of studies; only one study used confounder-adjusted analysis.\n- Data were heavily skewed toward IBD patients, limiting psoriasis-specific and IL-17-specific conclusions.","practice_takeaway":"Available data are broadly reassuring but insufficient to issue definitive safety guidance; clinicians should weigh uncontrolled disease risk against medication uncertainty on a case-by-case basis. Existing psoriasis registries (e.g., BADBIR, BioCAPTURE) should add standardized pregnancy datasets to accelerate evidence generation."}},{"doi":"10.2340/actadv.v106.adv-2026-0461","pmid":"42257527","title":"Prior Specific Biologic Use as a Potential Risk Factor for Administration-related Reactions to Ixekizumab after Excipient Modification: A Single-centre Retrospective Study","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-06-08T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2026-0461","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-10T14:24:43.016Z","updated_at":"2026-06-10T14:24:43.016Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"brand","value":"Taltz","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"condition","value":"Erythrodermic Psoriasis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"condition","value":"Generalized Pustular Psoriasis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"condition","value":"Plaque Psoriasis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"generic","value":"ixekizumab","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"generic","value":"secukinumab","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"modality","value":"IL-17A Inhibitor","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"sample_size","value":"n=23","value_numeric":23},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"warning","value":"All authors have disclosed financial relationships with multiple pharmaceutical companies, including Eli Lilly (ixekizumab manufacturer), which may introduce bias.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"warning","value":"ARR definition relied on clinical records from a single centre, with potential for ascertainment variability.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0461","tag_type":"warning","value":"Very small sample size (n=23) produces highly imprecise odds ratios (e.g., 95% CI 1.41–192.00); findings should be considered hypothesis-generating only.","value_numeric":null}],"summaries":{"what_studied":"This single-centre retrospective study examined risk factors for administration-related reactions (ARRs) to the modified (citrate-free) ixekizumab formulation in 23 psoriasis patients treated between January 2023 and December 2025.","key_result":"7 of 23 patients (30.4%) developed ARRs; 6 of those 7 had switched from secukinumab. Multivariate logistic regression showed prior secukinumab use was significantly associated with ARRs (OR 16.40, 95% CI 1.41–192.00, p=0.03). All ARRs were grade 1; 4 women discontinued ixekizumab due to intolerable reactions.","limitations":"Very small sample size (n=23) from a single centre limits generalisability; wide confidence intervals reflect imprecision; no mechanistic data to confirm causal pathway between prior secukinumab use and ARRs.","practice_takeaway":"When switching psoriasis patients from secukinumab to ixekizumab, counsel them about a higher likelihood of injection-site reactions, even with the newer citrate-free formulation. Monitor closely after the first dose and have a contingency plan if reactions are intolerable."}},{"doi":"10.1001/jamadermatol.2026.1753","pmid":"42139049","title":"Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-05-15T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2026.1753","source_score":15,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-18T13:25:20.466Z","updated_at":"2026-05-18T13:25:20.466Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"brand","value":"Taltz","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"brand","value":"Zepbound","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"condition","value":"Overweight","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"condition","value":"Plaque Psoriasis","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"generic","value":"ixekizumab","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"generic","value":"tirzepatide","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"modality","value":"GIP/GLP-1 Receptor Agonist","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"modality","value":"IL-17A Inhibitor","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"sample_size","value":"n=274","value_numeric":274},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"warning","value":"Level of evidence tagged as '2' rather than '1' due to open-label (non-blinded) design despite randomization.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"warning","value":"Open-label design (not blinded) is a notable methodological limitation that the authors acknowledge; objective endpoints like PASI may be less prone to bias, but weight-related outcomes could be influenced.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1753","tag_type":"warning","value":"The trial is ongoing (52-week endpoint not yet reported); results here reflect the week 36 primary endpoint only.","value_numeric":null}],"summaries":{"what_studied":"Phase 3b RCT (n=274) evaluating ixekizumab + tirzepatide vs. ixekizumab alone (both with diet and exercise) over 52 weeks in adults with moderate-to-severe plaque psoriasis and overweight/obesity (mean BMI 39.2) at 72 US sites; primary endpoint assessed at week 36.","key_result":"At week 36, 27.1% on combination therapy vs. 5.8% on ixekizumab alone simultaneously achieved PASI 100 and ≥10% weight loss (RD 21.2%; 95% CI 12.8%–29.7%; P<.001). PASI 100 alone: 40.6% vs. 29.0% (P=.04). ≥10% weight reduction: 69.2% vs. 9.1% (RD 60.0%). GI adverse events were more common in the combination arm.","limitations":"Open-label design may introduce assessment bias. The trial was conducted exclusively at US sites, limiting generalizability. Week 52 data were not yet available at the time of analysis.","practice_takeaway":"For patients with moderate-to-severe psoriasis and obesity, adding tirzepatide to ixekizumab produces substantially greater skin clearance and weight loss than ixekizumab alone, with no new safety signals. Clinicians should counsel patients on higher rates of GI side effects with the combination."}},{"doi":"10.1001/jamadermatol.2026.1694","pmid":"42139041","title":"Targeting Cardiometabolic Disease to Improve Psoriasis—A New Treatment Paradigm Emerges","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-05-15T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2026.1694","source_score":14,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-18T13:25:20.020Z","updated_at":"2026-05-18T13:25:20.020Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"brand","value":"Mounjaro","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"brand","value":"Taltz","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"condition","value":"Cardiometabolic Disease","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"condition","value":"Psoriasis","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"generic","value":"ixekizumab","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"generic","value":"tirzepatide","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"modality","value":"GLP-1/GIP Receptor Agonist","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"modality","value":"IL-17 Inhibitor","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"study_design","value":"Editorial / Commentary on Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"warning","value":"Brand name 'Mounjaro' listed for tirzepatide reflects its obesity/diabetes indication branding; the editorial does not specify a brand name.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"warning","value":"No sample size for the TOGETHER-PsO trial is reported in this editorial; the sample_size tag has been omitted accordingly.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"warning","value":"Several authors report financial relationships with manufacturers of relevant drugs (Novo Nordisk, Lilly, AbbVie, Johnson & Johnson, Pfizer, others), which should be considered when interpreting the editorial framing.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1694","tag_type":"warning","value":"This is an editorial commentary, not the primary trial report — specific trial data (e.g., PASI 100 rates, metabolic outcomes) are cited from the TOGETHER-PsO trial paper (Lebwohl et al., JAMA Dermatol 2026) and cannot be fully verified from this text alone.","value_numeric":null}],"summaries":{"what_studied":"This editorial discusses the TOGETHER-PsO phase 3b trial, which added tirzepatide (GLP-1/GIP agonist) to ixekizumab (IL-17 biologic) vs. ixekizumab alone in adults with moderate-to-severe psoriasis and overweight/obesity over 36 weeks, and argues for a new cardiometabolic treatment paradigm in psoriasis.","key_result":"At week 36, 40.6% of patients on ixekizumab + tirzepatide achieved PASI 100 vs. 29.0% on ixekizumab alone (P = .04); 27.1% vs. 5.8% met the composite primary endpoint of PASI 100 plus ≥10% weight loss (P < .001). The combination also reduced triglycerides by ~30 mg/dL and systolic blood pressure by ~10 mm Hg.","limitations":"- Trial was open-label with no placebo control, making skin benefit estimates imprecise and potentially biased.\n- Skin improvement was a secondary endpoint, limiting the strength of that inference.\n- It is unclear whether benefit came from tirzepatide's direct anti-inflammatory effects, weight loss, or improved ixekizumab pharmacokinetics.","practice_takeaway":"Dermatologists treating moderate-to-severe psoriasis in patients with overweight or obesity should screen routinely for cardiometabolic risk factors (BP, HbA1c, lipids, BMI) and consider collaborative care with cardiologists or obesity specialists. Adding tirzepatide to IL-17 biologic therapy may improve both skin clearance and cardiovascular risk factors simultaneously."}},{"doi":"10.1001/jamadermatol.2025.2972","pmid":"40900466","title":"Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2025-09-03T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2025.2972","source_score":13,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-21","doi":"10.1001/jamadermatol.2025.2972","days":"7","issn":"2168-6068","rank":"10","field":"Clinical Medicine","score":"13","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1001/jamadermatol.2025.2972","title":"Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events.","journal":"JAMA dermatology","methods":"","results":"Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk (P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change.","abstract":"$30","keywords":[],"pubmed_id":"40900466","conclusions":"","publication_date":"2025-09-03T00:00:00"},"crossref":{"DOI":"10.1001/jamadermatol.2025.2972","URL":"https://doi.org/10.1001/jamadermatol.2025.2972","ISSN":["2168-6068"],"link":[{"URL":"https://jamanetwork.com/journals/jamadermatology/articlepdf/2838219/jamadermatology_raby_2025_oi_250041_1762976601.59148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1107","type":"journal-article","issue":"11","score":1,"title":["Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events"],"author":[{"given":"Maxime","family":"Raby","sequence":"first","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, France"}]},{"given":"Frederic","family":"Balusson","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Department of Clinical Pharmacology, Rennes Hospital, France"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Department of Clinical Pharmacology, Rennes Hospital, France"}]},{"given":"Marion","family":"Gundelwein","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"}]},{"given":"Alain","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, France"}]},{"given":"Florence","family":"Poizeau","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, France"}]}],"issued":{"date-parts":[[2025,11,1]]},"member":"10","prefix":"10.1001","source":"Crossref","volume":"161","created":{"date-time":"2025-09-03T15:00:28Z","timestamp":1756911628000,"date-parts":[[2025,9,3]]},"indexed":{"date-time":"2025-11-19T16:04:21Z","timestamp":1763568261864,"date-parts":[[2025,11,19]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://jamanetwork.com/journals/jamadermatology/fullarticle/2838219"}},"subtitle":[],"deposited":{"date-time":"2025-11-19T16:00:39Z","timestamp":1763568039000,"date-parts":[[2025,11,19]]},"issn-type":[{"type":"print","value":"2168-6068"}],"published":{"date-parts":[[2025,11,1]]},"publisher":"American Medical Association (AMA)","reference":[{"DOI":"10.1093/eurheartj/ehr285","key":"doi250041r1","year":"2012","issue":"16","author":"Ahlehoff","volume":"33","first-page":"2054","unstructured":null,"article-title":"Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish 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(secukinumab, ixekizumab, brodalumab) triggers major adverse cardiovascular events (MACEs) within 6 months, using TNF‑α inhibitors (adalimumab, etanercept) as an active comparator. Among 34,241 IL‑17(R)A recipients, 381 MACEs were analyzed; risk and reference windows were the 6 months before the MACE and the preceding 6 months.","key_result":"Initiation of IL‑17(R)A inhibitors was not significantly associated with MACEs (OR 1.25, 95% CI 0.75–2.08); TNF‑α inhibitor initiation also showed no association (OR 0.90, 95% CI 0.65–1.24). Compared with TNF‑α inhibitors, IL‑17(R)A initiation had an OR of 1.40 (95% CI 0.77–2.54) over 6 months, with similar findings across cardiovascular risk strata (P for homogeneity = .29) and unchanged results in sensitivity analyses (broader MACE definition; 3‑month risk window).","limitations":"Only early risk windows (3–6 months) were evaluated, so longer‑term risk was not assessed. Precision was limited by 381 MACEs, yielding wide confidence intervals that do not exclude a modest risk increase.","practice_takeaway":"In this large real‑world analysis, starting an IL‑17(R)A inhibitor did not show a significant increase in 6‑month MACEs versus TNF‑α inhibitors, across cardiovascular risk levels. Continue standard cardiovascular risk management; a small increase in early events cannot be ruled out."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"category","value":"Dermatology"},{"tag_type":"brand","value":"Taltz"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Dermatology","href":"/hub/Dermatology"},{"name":"brand: Taltz","metadata":{"type":"brand","value":"Taltz"}}],"hrefConfig":{"basePath":"/hub/Dermatology/papers","webViewQueryParams":{"hub_ctx":"category_tag","hub_category":"Dermatology","hub_tag_type":"brand","hub_tag_value":"Taltz"}}}]]

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