2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T8b3,Psoriasis is a chronic immune-mediated disease associated with cardiovascular, metabolic, musculoskeletal, psychiatric, hepatic, kidney, and pulmonary comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved by the US Food and Drug Administration for type 2 diabetes, obesity, cardiovascular risk reduction, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction-associated steatohepatitis-conditions common in psoriasis. Emerging evidence suggests GLP-1 RAs and dual glucose-dependent insulinotropic polypeptide/GLP-1 agonists may improve psoriatic skin disease, partly through immune modulation. If confirmed in larger randomized clinical trials, GLP-1-based therapies may offer an opportunity to address both cutaneous disease and cardiometabolic comorbidities. This primer from the US National Psoriasis Foundation Medical Board sought to provide an evidence-informed narrative synthesis and practical considerations to introduce dermatologists to GLP-1 RAs for psoriasis treatment. GLP-1 RAs have been associated with reductions in Psoriasis Area and Severity Index (PASI) scores, particularly in patients with obesity or type 2 diabetes. Studies report relative PASI reductions ranging from approximately 40% to 80% with parallel quality-of-life gains, although most of these studies are small (7-48 patients), short term (≤6 months), and lack a control group. Semaglutide and liraglutide have been associated with reductions in C-reactive protein, interleukin-6, lipids, and visceral adiposity. In small, translational cohorts, PASI improvement has been correlated with reductions in superficial adiposity and dermal γδ T-cell density. GLP-1 RAs combine safely with methotrexate, cyclosporine, and biologics. Adverse effects are mainly transient gastrointestinal symptoms; pancreatitis and gallbladder events are rare. Early data show both metabolic and immunomodulatory benefits. This review found that GLP-1-based therapies target shared metabolic and inflammatory pathways in psoriasis. Current evidence supports consideration of adjunctive use in selected patients with metabolic comorbidities, although definitive conclusions await larger randomized clinical trials.31:Tabe, Importance Psoriasis is a chronic immune-mediated disease associated with cardiovascular, metabolic, musculoskeletal, psychiatric, hepatic, kidney, and pulmonary comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved by the US Food and Drug Administration for type 2 diabetes, obesity, cardiovascular risk reduction, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction–associated steatohepatitis—conditions common in psoriasis. Emerging evidence suggests GLP-1 RAs and dual glucose-dependent insulinotropic polypeptide/GLP-1 agonists may improve psoriatic skin disease, partly through immune modulation. If confirmed in larger randomized clinical trials, GLP-1–based therapies may offer an opportunity to address both cutaneous disease and cardiometabolic comorbidities. This primer from the US National Psoriasis Foundation Medical Board sought to provide an evidence-informed narrative synthesis and practical considerations to introduce dermatologists to GLP-1 RAs for psoriasis treatment. Observations GLP-1 RAs have been associated with reductions in Psoriasis Area and Severity Index (PASI) scores, particularly in patients with obesity or type 2 diabetes. Studies report relative PASI reductions ranging from approximately 40% to 80% with parallel quality-of-life gains, although most of these studies are small (7-48 patients), short term (≤6 months), and lack a control group. Semaglutide and liraglutide have been associated with reductions in C-reactive protein, interleukin-6, lipids, and visceral adiposity. In small, translational cohorts, PASI improvement has been correlated with reductions in superficial adiposity and dermal γδ T-cell density. GLP-1 RAs combine safely with methotrexate, cyclosporine, and biologics. Adverse effects are mainly transient gastrointestinal symptoms; pancreatitis and gallbladder events are rare. Early data show both metabolic and immunomodulatory benefits. Conclusions and Relevance This review found that GLP-1–based therapies target shared metabolic and inflammatory pathways in psoriasis. Current evidence supports consideration of adjunctive use in selected patients with metabolic comorbidities, although definitive conclusions await larger randomized clinical trials. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cardiovascular Disease in Dermatology: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed Dermatology papers on Cardiovascular Disease (condition). Clinician-written summaries and practical action steps. 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Estimated 10-year CVR was significantly higher in AD patients (p=0.04). Greater disease severity (v-IGA) correlated with higher fasting glucose and resting heart rate.","limitations":"- Cross-sectional, single-centre design prevents causal inference and limits generalizability.\n- No correction for multiple comparisons; several borderline findings (e.g., PWV trend, 30-year CVR) should be interpreted cautiously.\n- PREVENT analysis restricted to ages 30–79 (n=31 patients, n=29 controls), reducing statistical power; inflammatory biomarkers were only measured in patients, not controls.","practice_takeaway":"Adults with moderate-to-severe AD carry a measurably higher 10-year cardiovascular risk than matched controls, driven partly by modifiable factors like diet, physical activity, and blood pressure. Clinicians managing AD—especially moderate-to-severe cases—should routinely screen for cardiometabolic risk and offer lifestyle counselling alongside standard skin-directed therapy."}},{"doi":"10.1111/jdv.70609","pmid":"42466607","title":"Cardiac structure and function in psoriasis: A cross‐sectional analysis of the\n PSOCADIA\n study","journal_title":"Journal of the European Academy of Dermatology and Venereology","journal_issn":"0926-9959","published_at":"2026-07-17T00:00:00.000Z","url":"https://doi.org/10.1111/jdv.70609","source_score":13,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-25T13:57:55.993Z","updated_at":"2026-07-25T13:57:55.993Z","tags":[{"paper_doi":"10.1111/jdv.70609","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"condition","value":"Cardiovascular Disease","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"condition","value":"Myocardial Dysfunction","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"condition","value":"Psoriasis","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"modality","value":"Echocardiography","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"sample_size","value":"n=2020","value_numeric":2020},{"paper_doi":"10.1111/jdv.70609","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"warning","value":"GLS cutoff of <16% used to define myocardial dysfunction — this threshold may differ from some institutional standards (some use ≤-20% or absolute value <18%), which could affect prevalence estimates.","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"warning","value":"Level of evidence assigned as 3 (cross-sectional with matched controls); the prospective cohort design adds some rigor but causality cannot be established.","value_numeric":null},{"paper_doi":"10.1111/jdv.70609","tag_type":"warning","value":"No drug or therapeutic intervention was studied; modality and brand/generic tags are not applicable here. Echocardiography is tagged as the diagnostic modality, not a treatment.","value_numeric":null}],"summaries":{"what_studied":"Cross-sectional analysis of 1010 adults with psoriasis vs. 1010 age- and sex-matched controls without inflammatory skin disease from the PSOCADIA prospective cohort (Copenhagen, Denmark), evaluating cardiac structure, function, and cardiometabolic risk factors via transthoracic echocardiography including global longitudinal strain (GLS).","key_result":"Myocardial dysfunction (GLS <16%) was nearly 3× more prevalent in psoriasis vs. controls (16.7% vs. 6.0%, p < 0.001), persisting after adjustment for cardiometabolic risk factors and atherosclerotic cardiovascular disease; prevalence did not differ across psoriasis severity, and higher BMI and diabetes were independently associated with myocardial dysfunction.","limitations":"Cross-sectional design limits causal inference; study population is from a single region (greater Copenhagen), limiting generalizability; skin disease was generally well-managed, so findings may not reflect all psoriasis populations.","practice_takeaway":"Even patients with mild or well-controlled psoriasis carry a higher burden of subclinical myocardial dysfunction—cardiovascular risk assessment, including attention to BMI and diabetes, should be routine across all psoriasis severity levels. Standard echocardiographic function (ejection fraction) may miss these subtle GLS abnormalities, so advanced imaging may warrant consideration in higher-risk patients."}},{"doi":"10.1016/j.jid.2026.06.1269","pmid":"42470402","title":"Updates on endothelial injury in dermatomyositis: Clinical correlations and potential mechanisms","journal_title":"Journal of Investigative Dermatology","journal_issn":"0022-202X","published_at":"2026-07-17T00:00:00.000Z","url":"https://doi.org/10.1016/j.jid.2026.06.1269","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-25T13:57:50.405Z","updated_at":"2026-07-25T13:57:50.405Z","tags":[{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"condition","value":"Cardiovascular Disease","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"condition","value":"Dermatomyositis","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"condition","value":"Pulmonary Fibrosis","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"warning","value":"Age group tagged as 'mixed' as the review does not specify a single studied population age range.","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"warning","value":"No original patient data or sample size reported — this is a narrative review; level of evidence is estimated at 5.","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"warning","value":"No specific therapeutic agents or modalities are discussed in the abstract; drug/modality tags could not be assigned.","value_numeric":null},{"paper_doi":"10.1016/j.jid.2026.06.1269","tag_type":"warning","value":"The paper is dated July 17, 2026, which is 8 days before today's date; it may be a recent ahead-of-print publication and details may be subject to change upon final publication.","value_numeric":null}],"summaries":{"what_studied":"This review evaluates the role of vascular endothelial cell (EC) injury in dermatomyositis (DM), covering its clinical correlations (edema, ulcers, capillary disturbances, muscle ischemia, cardiovascular risk) and proposed mechanisms linking EC damage to skin, muscle, and pulmonary involvement.","key_result":"EC injury appears central to vascular damage in DM; clinical features tied to vascular damage (edema, ulcers, severe microcirculatory disturbances) correlate with more severe disease, and cardiovascular disease risk in DM patients is significantly elevated compared to healthy individuals.","limitations":"Review article without original patient data — no sample size, effect sizes, or direct clinical trial results are reported. Mechanistic evidence is largely experimental, and many proposed pathways require further validation in humans.","practice_takeaway":"Clinicians should recognize vascular features like edema, ulcers, and capillary abnormalities in DM as markers of more severe disease. Monitoring cardiovascular risk in DM patients is warranted, and EC-related biomarkers may emerge as useful disease activity indicators."}},{"doi":"10.1001/jamadermatol.2026.1070","pmid":"42126867","title":"Text Messaging for Cardiovascular Risk Prevention in Psoriasis","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-05-13T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13173419/","source_score":12,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-18T13:25:19.663Z","updated_at":"2026-05-18T13:25:19.663Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"condition","value":"Cardiovascular Disease","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"condition","value":"Psoriasis","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"modality","value":"Digital Health Intervention","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"modality","value":"Text Messaging","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"sample_size","value":"n=111","value_numeric":111},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"warning","value":"Full text is under PMC embargo until May 13, 2027; summary is based solely on the abstract and reported results—detailed methods, subgroup analyses, and adverse event data are unavailable.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"warning","value":"Single-center Australian tertiary clinic population may not reflect diverse or community dermatology settings.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1070","tag_type":"warning","value":"The impact flag 'confirms_prior' reflects that text-messaging behavioral interventions have shown benefit in other cardiometabolic conditions, but this is among the first RCTs specifically in psoriasis.","value_numeric":null}],"summaries":{"what_studied":"A 6-month text-messaging intervention (TEXTME PSO, 4 texts/week) vs. standard care in 111 adults with dermatologist-confirmed psoriasis, evaluated for effects on patient activation and cardiovascular risk factors at a single Australian tertiary dermatology clinic (April–July 2024 enrollment, 6-month follow-up).","key_result":"The intervention significantly improved patient activation (adjusted mean difference +10.8 points; 95% CI 7.0–14.6; P<.001), Mediterranean diet adherence (+1.7; P<.001), medication adherence (+1.6; P<.001), psoriasis-CVD knowledge (+6.6; P<.001), physical activity (+127.9 min/week; P=.02), and BMI (−1.0; P<.001). No significant changes were seen in lipids, HbA1c, smoking, quality of life, or psoriasis severity.","limitations":"- Single-center trial at one Australian tertiary hospital limits generalizability.\n- Biomarker changes (lipids, HbA1c) were not statistically significant, so cardiovascular hard-outcome benefit is unproven.\n- Short 6-month follow-up cannot capture long-term CVD event reduction.","practice_takeaway":"A simple weekly text-messaging program can meaningfully boost patient engagement and healthy behaviors in psoriasis patients seen in dermatology—consider adding digital tools to standard care for CVD risk reduction. Biomarker and hard-outcome benefits remain to be demonstrated in longer trials."}},{"doi":"10.1093/bjd/ljag182","pmid":"42114107","title":"Cardiovascular Comorbidities and Risk in Hidradenitis Suppurativa: A Systematic Review and Meta-analysis","journal_title":"British Journal of Dermatology","journal_issn":"0007-0963","published_at":"2026-05-11T00:00:00.000Z","url":"https://doi.org/10.1093/bjd/ljag182","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-19T13:22:58.667Z","updated_at":"2026-05-19T13:22:58.667Z","tags":[{"paper_doi":"10.1093/bjd/ljag182","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Cardiovascular Disease","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Coronary Artery Disease","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Heart Failure","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Hidradenitis Suppurativa","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Hypertension","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Myocardial Infarction","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"condition","value":"Venous Thromboembolism","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"sample_size","value":"n=373689","value_numeric":373689},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"warning","value":"GRADE certainty of evidence was rated low for all outcomes due to observational study designs and inconsistent confounder adjustment — relative risk estimates should be interpreted cautiously.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"warning","value":"Substantial statistical heterogeneity was present across most meta-analyses; pooled estimates may not be uniformly applicable across HS subpopulations.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag182","tag_type":"warning","value":"The impact_flag 'practice_changing' reflects the clinical recommendation to add cardiovascular risk assessment to HS management, but the underlying evidence is observational and low certainty.","value_numeric":null}],"summaries":{"what_studied":"This systematic review and meta-analysis (25 studies, n=373,689 HS patients) quantified the prevalence of cardiovascular comorbidities in hidradenitis suppurativa (HS) and evaluated the association between HS and cardiovascular outcomes compared to individuals without HS, searching databases from inception through June 2025.","key_result":"Hypertension affected ~25% of HS patients. HS was associated with 1.3- to 1.8-fold increased relative risk for ischemic/coronary heart disease, composite cardiovascular disease, myocardial infarction, heart failure, venous thromboembolism, and all-cause mortality vs. non-HS comparators.","limitations":"- All included studies were observational, limiting causal inference.\n- Substantial heterogeneity was present across most meta-analyses.\n- Variability in confounder adjustment and non-standardized cardiovascular outcome definitions reduce certainty (GRADE: low).","practice_takeaway":"Clinicians managing HS should routinely assess cardiovascular risk, given a 1.3–1.8× elevated risk of major cardiovascular outcomes. Screening for hypertension, coronary artery disease, and heart failure is particularly warranted."}},{"doi":"10.1001/jamadermatol.2026.0859","pmid":"42054048","title":"The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2026.0859","source_score":217,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-06","doi":"10.1001/jamadermatol.2026.0859","days":"14","issn":"2168-6068","rank":"1","field":"Clinical Medicine","score":"217","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1001/jamadermatol.2026.0859","title":"The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis: A Review.","journal":"JAMA 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