Mediterranean Diet and Patients With Psoriasis
Clinical Summary
View sourceWhat was studied
An open-label, single-center, evaluator-blinded randomized clinical trial tested a 16-week, dietitian-guided Mediterranean diet versus standard low-fat advice in adults with mild to moderate psoriasis on stable topical therapy.
Key findings
At 16 weeks, the EMM PASI change was -3.4 (95% CI, -4.4 to -2.4) with the Mediterranean diet vs 0.0 (95% CI, -1.0 to 1.0) with control; between-group EMM difference -3.4 (95% CI, -4.8 to -2.0; P<.001). PASI 75 was reached by 9/19 (47.4%) in the Mediterranean diet group vs 0 in control. HbA1c improved with a between-group EMM difference of -4.1 mmol/mol (95% CI, -6.9 to -1.3; P=.01).
Study limitations
Small, single-center study (n=38) with a short 16-week follow-up. Open-label design with evaluator blinding only and greater contact in the intervention arm (dietitian-guided) may introduce performance and attention bias. Findings apply to mild to moderate psoriasis on stable topical therapy and may not generalize to severe disease.
Clinical implications
For adults with mild to moderate psoriasis on stable topical therapy, a 16-week, dietitian-guided Mediterranean diet produced clinically meaningful PASI reductions and better HbA1c versus standard low-fat advice. Consider offering a Mediterranean-style diet program as an adjunct to topical treatment.
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