Journal of Investigative Dermatology

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Molecular regulation of angiogenesis and lymphangiogenesis

Nat Rev Mol Cell Biol

The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5

J Virol

The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art

Angiogenesis

MicroRNAs: target recognition and regulatory functions

Cell

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins

J Proteome Res

The three M's: melanoma, microphthalmia-associated transcription factor and microRNA

Pigment Cell Melanoma Res

Melanosome transfer to and translocation in the keratinocyte

Exp Dermatol

The role of VEGF-C staining in predicting regional metastasis in melanoma

Virchows Arch

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Oncoimmunology

Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?

Prog Retin Eye Res

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

J Clin Invest

Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

J Cutan Pathol

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment

Endothelial cell tube formation assay for the in vitro study of angiogenesis

J Vis Exp

Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo

Melanoma miRNA trafficking controls tumour primary niche formation

Nat Cell Biol

Surgical management of the groin lymph nodes in melanoma in the era of sentinel lymph node dissection

Arch Surg

Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy

Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

eLife

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Cell Mol Life Sci

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

J Exp Med

Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis

Cancer Res

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications

The role of melanoma cell-stroma interaction in cell motility, invasion, and metastasis

Front Med (Lausanne)

Gene structure and function of the 2'-5'-oligoadenylate synthetase family

Causal analysis approaches in Ingenuity Pathway Analysis

Bioinformatics

Role of dicer and drosha for endothelial microRNA expression and angiogenesis

Circ Res

Why do melanomas get so dark?

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

Genes Dev

Claisened hexafluoro inhibits metastatic spreading of amoeboid melanoma cells

Cancers (Basel)

Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor

Int J Oncol

Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor

Lymphatic invasion identified by monoclonal antibody D2-40, younger age, and ulceration: predictors of sentinel lymph node involvement in primary cutaneous melanoma

Arch Dermatol

Melanosomes are specialized members of the lysosomal lineage of organelles

J Invest Dermatol

Exosomes as a communication tool between the lymphatic system and bladder cancer

Int Neurourol J

Blood microvessel density, lymphatic microvessel density and lymphatic invasion in predicting melanoma metastases: systematic review and meta-analysis

Br J Dermatol

Interferon regulatory factor 9 structure and regulation

Front Immunol

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Nat Med

IFI6 inhibits apoptosis via mitochondrial-dependent pathway in dengue virus 2 infected vascular endothelial cells

PLoS One

Melanosomes--dark organelles enlighten endosomal membrane transport

Comparing the hem- and lymphangiogenic profile of conjunctival and uveal melanoma cell lines

Invest Ophthalmol Vis Sci

BeadArray expression analysis using bioconductor

PLoS Comput Biol

limma powers differential expression analyses for RNA-sequencing and microarray studies

Nucleic Acids Res

The let-7 family of microRNAs

Trends Cell Biol

The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations

Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans

Influence of IFN- alpha and IFN- gamma on lymphangiogenesis

J Interferon Cytokine Res

The regulatory role of microRNAs in angiogenesis-related diseases

J Cell Mol Med

Lymph protects metastasizing melanoma cells from ferroptosis

Nature

Isolation of melanosomes

Curr Protoc Cell Biol

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Innovation (Camb)

Mutations associated with acquired resistance to PD-1 blockade in melanoma

N Engl J Med

Interferon-alpha regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders

STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

Blood

Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma

Mol Cell

Melanoma, the deadliest cutaneous tumor, initiates within the epidermis; during progression, cells invade into the dermis and become metastatic through the lymphatic and blood system. Before melanoma cell invasion into the dermis, an increased density of dermal lymphatic vessels is observed, generated by a mechanism which is not fully understood. In this study, we show that, while at the primary epidermal stage (in situ), melanoma cells secrete extracellular vesicles termed melanosomes, which are uptaken by dermal lymphatic cells, leading to transcriptional and phenotypic pro-lymphangiogenic changes. Mechanistically, melanoma-derived melanosomes traffic mature let-7i to lymphatic endothelial cells, which mediate pro-lymphangiogenic phenotypic changes by the induction of type I IFN signaling. Furthermore, transcriptome analysis upon treatment with melanosomes or let-7i reveals the enhancement of IFI6 expression in lymphatic cells. Because melanoma cells metastasize primarily via lymphatic vessels, our data suggest that blocking lymphangiogenesis by repressing either melanosome release or type I IFN signaling will prevent melanoma progression to the deadly metastatic stage.

Primary Melanoma miRNA Trafficking Induces Lymphangiogenesis.

Primary Melanoma miRNA Trafficking Induces Lymphangiogenesis

Primary Melanoma miRNA Trafficking Induces Lymphangiogenesis

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