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First Alzheimer Disease Blood Test May Produce Many False-Positive Results, Study Finds

JAMA·July 2
Medicine, General & InternalSafety signalAlzheimer DiseaseMedical News / CommentaryPlasma Biomarker TestOlder Adult

Summary

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What was studied

Real-world performance of the first approved plasma biomarker test for Alzheimer disease pathology, focusing on the rate of false-positive results in clinical use.

Key findings

The study found that the approved plasma Alzheimer disease test may produce a substantial number of false-positive results when used in real-world settings, though specific numeric rates are not provided in the abstract.

Study limitations

This is a Medical News summary article, not the primary research; full methodology, sample size, and quantitative results of the underlying JAMA Neurology study are not detailed in the abstract.

Clinical implications

Clinicians using the first approved plasma Alzheimer biomarker test should be aware of the potential for false positives in real-world practice, and confirmatory testing or clinical correlation may be warranted before acting on results.

Related Questions

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What is the specificity and false-positive rate of plasma p-tau217 tests for Alzheimer disease in real-world populations?How should clinicians confirm a positive plasma Alzheimer biomarker test result before making a diagnosis?What are the approved plasma biomarker tests for Alzheimer disease and their performance characteristics compared to PET or CSF?

Publication Details

Year
2026
Journal
JAMA
Source
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