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Melasma

JAMA Dermatology·July 8
DermatologyLimited evidenceMelasmaPatient Education / ReviewChemical PeelLaser TherapyMicroneedlingTopical Depigmenting AgentAdultTranexamic Acid

Summary

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What was studied

This Patient Page covers the causes, symptoms, diagnosis, and treatment options for melasma, targeting a general and clinical audience.

Key findings

Melasma affects about 1 in 100 people, is most common in women of reproductive age, and is more prevalent in those of African, Asian, Hispanic, and Middle Eastern ancestry. Treatments (topical agents, oral tranexamic acid, procedures) can improve but not cure the condition, with improvement often taking several months.

Study limitations

This is a patient education summary, not an original research study — no primary data, control groups, or outcome measures are reported.

Clinical implications

Counsel patients that daily broad-spectrum tinted sunscreen (SPF ≥30), topical lightening agents, and — for severe cases — oral tranexamic acid are the mainstays of management. Set clear expectations: melasma is chronic, improvement takes months, and procedures should be done by a board-certified dermatologist to minimize adverse effects.

Caveats

  • Level of evidence is assigned as 7 (expert opinion/patient education material) given the absence of study methodology or data.
  • Study design label 'Patient Education / Review' is used as no standard research design applies.
  • This is a JAMA Dermatology Patient Page (lay education article), not a primary research study or systematic review — no original data or statistical findings are reported.

Related Questions

Explore related topics

What is the evidence for oral tranexamic acid in treating melasma?How do tinted vs. untinted sunscreens compare for melasma prevention?Which laser or procedure works best for melasma in darker skin tones?

Publication Details

Year
2026
Journal
JAMA Dermatology
Source
View article
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