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Physical Fitness and All-Cause Mortality in Older Adults

JAMA Network Open·August 10Open Access
Medicine, General & InternalPractice changingAll-Cause MortalityPhysical DeconditioningProspective Cohort StudyBalance And Agility TestingCardiorespiratory Fitness TestingPhysical Fitness AssessmentOlder Adult

Summary

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What was studied

This nationwide cohort study in Taiwan evaluated associations between objectively measured physical fitness across 4 domains (cardiorespiratory fitness, muscular strength, flexibility, balance/agility) and all-cause mortality in 13,423 community-dwelling adults aged ≥65 years, with up to ~7 years of follow-up (2015–2022).

Key findings

12.2% of participants died over median 7.0 years. Compared to the lowest quintile, the highest quintile had significantly lower mortality: 8-foot up-and-go (AHR 0.41), 1-leg stance (AHR 0.50), 30-second chair stand (AHR 0.55), and 2-minute step test (AHR 0.58). A composite fitness index showed the strongest protection (AHR 0.39, 95% CI 0.32–0.48).

Study limitations

- Single-country cohort (Taiwan) limits generalizability to other populations. - Self-reported physical activity was used as a covariate, introducing potential recall bias. - Fitness was measured only at baseline; changes in fitness over time were not captured.

Clinical implications

Routine objective fitness testing — especially balance, agility, and lower-body strength — can meaningfully stratify mortality risk in older adults beyond comorbidity burden alone. Clinicians should consider integrating simple tests like the 8-foot up-and-go and 1-leg stance into geriatric assessments to guide function-oriented interventions.

Related Questions

Explore related topics

Which bedside fitness tests best predict mortality risk in older adults?How does grip strength or chair stand performance compare to cardiorespiratory fitness for predicting survival in elderly patients?Should geriatric risk stratification include objective functional fitness assessments instead of relying only on comorbidities?

Publication Details

Year
2026
Journal
JAMA Network Open
Sample Size
n=13,423
Source
View article
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