A randomized crossover nondispensing trial evaluated the Deseyne extended depth of focus (EDOF) daily wear contact lens versus a monofocal control lens in 78 presbyopic habitual soft lens wearers aged 45–70 years (mean 53.9 years), assessing monocular visual acuity at distance, intermediate, and near, depth of focus, and mesopic contrast sensitivity.
The Deseyne lens extended depth of focus by a mean of 0.78 D (95% CI: 0.63–0.93 D) vs. monofocal control (2.22 D vs. 1.44 D). Near VA improved to +0.20 vs. +0.35 logMAR and intermediate VA to +0.02 vs. +0.16 logMAR, but distance VA was slightly worse (0.00 vs. −0.07 logMAR). Contrast sensitivity was significantly reduced at 3, 6, and 12 cycles per degree, both with and without glare.
- Nondispensing design (single visit, no real-world wear period) limits generalizability to daily use outcomes. - Only monocular measurements reported; binocular performance — more relevant to patients — was not assessed. - Sample restricted to spherical errors (−6.00 to +4.00 D) with <1.25 D astigmatism, limiting applicability to patients outside this range.
The Deseyne EDOF contact lens meaningfully improves intermediate and near vision in presbyopic soft lens wearers, but clinicians should counsel patients about a modest reduction in contrast sensitivity compared to monofocal lenses. Distance vision is slightly compromised, so patient selection and expectation-setting are important.
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