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The relationship between gestational age, delivery, and fetal size, and neurodevelopment outcomes from infancy to adolescence
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The relationship between gestational age, delivery, and fetal size, and neurodevelopment outcomes from infancy to adolescence

American Journal of Obstetrics and Gynecology·August 26Open Access
Obstetrics & GynecologyPractice changingFetal Growth RestrictionNeurodevelopmental DelayPreterm And Early Term BirthSmall For Gestational AgeProspective Cohort StudyAdolescentChildInfant

Summary

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What was studied

Among 92,551 term-born children (37–41 weeks) from the Norwegian MoBa cohort, this study compared how gestational age and fetal size (SGA, AGA, LGA) independently associate with neurodevelopment from infancy through adolescence, using parent-reported language/motor milestones at 6, 18 months, 3, and 5 years, and national test scores in Math, Reading, and English at grades 5, 8, and 9.

Key findings

Earlier term birth was linked to worse early language and motor development, but effects faded by age 5. SGA had a more durable impact: lower math scores persisted into adolescence at ages 10–11 (β = −2.32), 13–14 (β = −1.79), and 14–15 years (β = −1.85). Gestational age and fetal size effects were statistically independent.

Study limitations

Outcomes relied partly on parent-reported developmental milestones, which may introduce reporting bias. The cohort is Norwegian, limiting generalizability to other populations. Congenital malformations were excluded, but other unmeasured confounders (e.g., socioeconomic factors, parental IQ) may persist.

Clinical implications

When counseling families after a term birth, treat fetal size and gestational age as separate risk signals — SGA carries lasting academic risk into adolescence, while early-term gestational age effects largely resolve by age 5. Do not use gestational age alone as a proxy for long-term neurodevelopmental risk in term-born children.

Caveats

  • National test scores as academic outcomes are specific to the Norwegian education system and may not map directly to other curricula.
  • The impact_flag 'practice_changing' reflects the study's large sample and clear divergence between GA and SGA effects over time, but replication in non-Nordic populations is needed before broad clinical adoption.
  • The study period extends to 2026 publication but uses longitudinal data collected from infancy onward; exact recruitment and follow-up dates are not specified in the abstract.

Related Questions

Explore related topics

Does being small for gestational age affect school performance long term?How does early term birth (37–38 weeks) impact childhood development compared to full term?Should SGA and gestational age be counseled separately for neurodevelopmental risk?

Publication Details

Year
2026
Journal
American Journal of Obstetrics and Gynecology
Sample Size
n=92,551
Source
View article
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