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Trastuzumab Deruxtecan Rechallenge in HER2-Positive Metastatic Breast Cancer: EN-SEMBLE

The Breast·July 22Open Access
Obstetrics & GynecologyHER2-Positive Metastatic Breast CancerAntibody-Drug ConjugateEnhertuTrastuzumab Deruxtecan

Summary

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What was studied

The EN-SEMBLE study evaluated trastuzumab deruxtecan (T-DXd) rechallenge in patients with HER2-positive metastatic breast cancer who had previously received and progressed on T-DXd.

Related Questions

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What is the evidence for T-DXd rechallenge in HER2-positive metastatic breast cancer?How does trastuzumab deruxtecan compare to other options after prior T-DXd progression in HER2-positive breast cancer?What are the resistance mechanisms to trastuzumab deruxtecan in HER2-positive metastatic breast cancer?

Publication Details

Year
2026
Journal
The Breast
Source
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