This study examined the association of tertiary lymphoid structures (TLS) in kidney biopsies of lupus nephritis (LN) patients with aging and markers of chronic kidney injury, including their clinical and histopathological correlates.
TLS in lupus nephritis were significantly associated with older patient age and features of chronic kidney injury; specific numeric outcomes were not extractable from the provided abstract.
Full text was not available for review, limiting extraction of specific sample sizes, effect sizes, and confounders; findings may not generalize across LN subtypes or treatment backgrounds.
Clinicians should be aware that TLS in LN biopsies may reflect chronic, age-related kidney damage rather than purely active inflammation — this distinction could influence how aggressively immunosuppression is escalated in older LN patients with TLS.
