A genetically encoded proximity labelling mouse model developed by Plucińska et al. to identify and capture cell-specific secretomes in plasma and tissue in response to physiological stressors in vivo.
The model enables cell-specific secretome mapping in living mice, overcoming prior technical barriers to identifying secreted proteins in vivo under physiological conditions.
Abstract-only source; specific cell types studied, stressors tested, and validation metrics are not reported here. Generalizability across different tissues and disease states is unclear from available text.
This tool is currently a research model and not directly actionable in clinical practice, but it may accelerate discovery of novel secreted protein targets relevant to endocrine and metabolic disease.
