This Lancet HIV Commission examined the global landscape of ageing with HIV, evaluating epidemiological trends, clinical complexities, and health system responses for people ageing with HIV across diverse global settings.
The Commission highlights that a growing proportion of people living with HIV are now older adults, facing multimorbidity, polypharmacy, frailty, and social isolation at higher rates than HIV-negative peers, with health systems largely unprepared to address these compounding needs.
As a Commission report, conclusions are based on synthesis of existing evidence rather than original primary data; the global scope may mask significant regional heterogeneity, particularly in low- and middle-income countries where data on older people with HIV remain sparse.
Clinicians should routinely screen older people with HIV for frailty, multimorbidity, and polypharmacy, integrating geriatric principles into HIV care. Health systems need dedicated models of care that address the intersecting challenges of ageing and HIV across all income settings.
