# paper.pdf ## Metadata - PDFFormatVersion=1.7 - IsLinearized=false - IsAcroFormPresent=false - IsXFAPresent=false - IsCollectionPresent=false - IsSignaturesPresent=false - Producer=pypdf ## Contents ### Page 1 Supplementary Table 1. Lipid species and classesLipid Species Group Class (Full name) Class (Abbreviation)Sph(d18:1) sphingolipids Sphingosine SphSph(d18:2) sphingolipids Sphingosine SphS1P(d16:1) sphingolipids Sphingosine-1-phosphate S1PS1P(d18:0) sphingolipids Sphingosine-1-phosphate S1PS1P(d18:1) sphingolipids Sphingosine-1-phosphate S1PS1P(d18:2) sphingolipids Sphingosine-1-phosphate S1PdhCer(d18:0/16:0) sphingolipids Dihydroceramide dhCerdhCer(d18:0/18:0) sphingolipids Dihydroceramide dhCerdhCer(d18:0/20:0) sphingolipids Dihydroceramide dhCerdhCer(d18:0/22:0) sphingolipids Dihydroceramide dhCerdhCer(d18:0/24:0) sphingolipids Dihydroceramide dhCerdhCer(d18:0/24:1) sphingolipids Dihydroceramide dhCerCer(d16:1/16:0) sphingolipids Ceramide Cer(d)Cer(d16:1/18:0) sphingolipids Ceramide Cer(d)Cer(d16:1/20:0) sphingolipids Ceramide Cer(d)Cer(d16:1/22:0) sphingolipids Ceramide Cer(d)Cer(d16:1/23:0) sphingolipids Ceramide Cer(d)Cer(d16:1/24:0) sphingolipids Ceramide Cer(d)Cer(d16:1/24:1) sphingolipids Ceramide Cer(d)Cer(d17:1/16:0) sphingolipids Ceramide Cer(d)Cer(d17:1/18:0) sphingolipids Ceramide Cer(d)Cer(d17:1/20:0) sphingolipids Ceramide Cer(d)Cer(d17:1/22:0) sphingolipids Ceramide Cer(d)Cer(d17:1/23:0) sphingolipids Ceramide Cer(d)Cer(d17:1/24:0) sphingolipids Ceramide Cer(d)Cer(d17:1/24:1) sphingolipids Ceramide Cer(d)Cer(d18:1/14:0) sphingolipids Ceramide Cer(d)Cer(d18:1/16:0) sphingolipids Ceramide Cer(d)Cer(d18:1/18:0) sphingolipids Ceramide Cer(d)Cer(d18:1/19:0) sphingolipids Ceramide Cer(d)Cer(d18:1/20:0) sphingolipids Ceramide Cer(d)Cer(d18:1/21:0) sphingolipids Ceramide Cer(d)Cer(d18:1/22:0) sphingolipids Ceramide Cer(d)Cer(d18:1/23:0) sphingolipids Ceramide Cer(d)Cer(d18:1/24:0) sphingolipids Ceramide Cer(d)Cer(d18:1/24:1) sphingolipids Ceramide Cer(d)Cer(d18:1/26:0) sphingolipids Ceramide Cer(d)Cer(d18:2/14:0) sphingolipids Ceramide Cer(d)Cer(d18:2/16:0) sphingolipids Ceramide Cer(d)Cer(d18:2/18:0) sphingolipids Ceramide Cer(d)Cer(d18:2/20:0) sphingolipids Ceramide Cer(d)Cer(d18:2/21:0) sphingolipids Ceramide Cer(d)Cer(d18:2/22:0) sphingolipids Ceramide Cer(d)Cer(d18:2/23:0) sphingolipids Ceramide Cer(d)Cer(d18:2/24:0) sphingolipids Ceramide Cer(d)Cer(d18:2/24:1) sphingolipids Ceramide Cer(d)Cer(d18:2/26:0) sphingolipids Ceramide Cer(d)Cer(d19:1/16:0) sphingolipids Ceramide Cer(d)Cer(d19:1/18:0) sphingolipids Ceramide Cer(d)Cer(d19:1/20:0) sphingolipids Ceramide Cer(d)Cer(d19:1/22:0) sphingolipids Ceramide Cer(d)Cer(d19:1/23:0) sphingolipids Ceramide Cer(d)Cer(d19:1/24:0) sphingolipids Ceramide Cer(d)Cer(d19:1/24:1) sphingolipids Ceramide Cer(d)Cer(d19:1/26:0) sphingolipids Ceramide Cer(d)Cer(d20:1/22:0) sphingolipids Ceramide Cer(d)Cer(d20:1/23:0) sphingolipids Ceramide Cer(d)Cer(d20:1/24:0) sphingolipids Ceramide Cer(d)Cer(d20:1/24:1) sphingolipids Ceramide Cer(d)Cer(m18:0/20:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:0/22:0) sphingolipids Deoxyceramide Cer(m) ### Page 2 Cer(m18:0/23:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:0/24:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:0/24:1) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/18:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/20:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/22:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/23:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/24:0) sphingolipids Deoxyceramide Cer(m)Cer(m18:1/24:1) sphingolipids Deoxyceramide Cer(m)Cer1P(d18:1/16:0) sphingolipids Ceramide-1-phosphate C1PHexCer(d16:1/18:0) sphingolipids Monohexosylceramide HexCerHexCer(d16:1/20:0) sphingolipids Monohexosylceramide HexCerHexCer(d16:1/22:0) sphingolipids Monohexosylceramide HexCerHexCer(d16:1/24:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/16:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/18:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/20:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/22:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/24:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:1/24:1) sphingolipids Monohexosylceramide HexCerHexCer(d18:2/18:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:2/20:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:2/22:0) sphingolipids Monohexosylceramide HexCerHexCer(d18:2/24:0) sphingolipids Monohexosylceramide HexCerHex2Cer(d16:1/16:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d16:1/24:1) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:1/16:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:1/20:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:1/22:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:1/24:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:1/24:1) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:2/16:0) sphingolipids Dihexosylceramide Hex2CerHex2Cer(d18:2/24:1) sphingolipids Dihexosylceramide Hex2CerHex3Cer(d18:1/16:0) sphingolipids Trihexosylcermide Hex3CerHex3Cer(d18:1/18:0) sphingolipids Trihexosylcermide Hex3CerHex3Cer(d18:1/20:0) sphingolipids Trihexosylcermide Hex3CerHex3Cer(d18:1/22:0) sphingolipids Trihexosylcermide Hex3CerHex3Cer(d18:1/24:0) sphingolipids Trihexosylcermide Hex3CerHex3Cer(d18:1/24:1) sphingolipids Trihexosylcermide Hex3CerGM3(d18:1/16:0) sphingolipids GM3 ganglioside GM3GM3(d18:1/18:0) sphingolipids GM3 ganglioside GM3GM3(d18:1/20:0) sphingolipids GM3 ganglioside GM3GM3(d18:1/22:0) sphingolipids GM3 ganglioside GM3GM3(d18:1/24:0) sphingolipids GM3 ganglioside GM3GM3(d18:1/24:1) sphingolipids GM3 ganglioside GM3GM1(d18:1/16:0) sphingolipids GM1 ganglioside GM1SHexCer(d18:1/16:0(OH)) sphingolipids Sulfatide SHexCerSHexCer(d18:1/16:0) sphingolipids Sulfatide SHexCerSHexCer(d18:1/24:0(OH)) sphingolipids Sulfatide SHexCerSHexCer(d18:1/24:0) sphingolipids Sulfatide SHexCerSHexCer(d18:1/24:1(OH)) sphingolipids Sulfatide SHexCerSHexCer(d18:1/24:1) sphingolipids Sulfatide SHexCerSM(34:3) sphingolipids Sphingomyelin SMSM(35:2) (b) sphingolipids Sphingomyelin SMSM(37:1) sphingolipids Sphingomyelin SMSM(37:2) sphingolipids Sphingomyelin SMSM(38:3) (a) sphingolipids Sphingomyelin SMSM(38:3) (b) sphingolipids Sphingomyelin SMSM(40:3) (a) sphingolipids Sphingomyelin SMSM(40:3) (b) sphingolipids Sphingomyelin SMSM(41:0) sphingolipids Sphingomyelin SMSM(41:1) (a) sphingolipids Sphingomyelin SMSM(43:1) sphingolipids Sphingomyelin SM ### Page 3 SM(43:2) (b) sphingolipids Sphingomyelin SMSM(43:2) (c) sphingolipids Sphingomyelin SMSM(44:1) sphingolipids Sphingomyelin SMSM(44:2) sphingolipids Sphingomyelin SMSM(44:3) sphingolipids Sphingomyelin SMSM(d16:1/19:0) sphingolipids Sphingomyelin SMSM(d16:1/23:0) & SM(d17:1/22:0) sphingolipids Sphingomyelin SMSM(d16:1/24:1) sphingolipids Sphingomyelin SMSM(d17:1/14:0) sphingolipids Sphingomyelin SMSM(d17:1/16:0) sphingolipids Sphingomyelin SMSM(d17:1/24:1) sphingolipids Sphingomyelin SMSM(d18:0/14:0) sphingolipids Sphingomyelin SMSM(d18:0/16:0) sphingolipids Sphingomyelin SMSM(d18:0/22:0) sphingolipids Sphingomyelin SMSM(d18:1/14:0) & SM(d16:1/16:0) sphingolipids Sphingomyelin SMSM(d18:1/16:0) sphingolipids Sphingomyelin SMSM(d18:1/17:0) & SM(d17:1/18:0) sphingolipids Sphingomyelin SMSM(d18:1/18:0) & SM(d16:1/20:0) sphingolipids Sphingomyelin SMSM(d18:1/20:0) & SM(d16:1/22:0) sphingolipids Sphingomyelin SMSM(d18:1/22:0) & SM(d16:1/24:0) sphingolipids Sphingomyelin SMSM(d18:1/23:0) & SM(d17:1/24:0) sphingolipids Sphingomyelin SMSM(d18:1/24:0) sphingolipids Sphingomyelin SMSM(d18:1/24:1) sphingolipids Sphingomyelin SMSM(d18:2/14:0) sphingolipids Sphingomyelin SMSM(d18:2/16:0) sphingolipids Sphingomyelin SMSM(d18:2/17:0) sphingolipids Sphingomyelin SMSM(d18:2/18:0) sphingolipids Sphingomyelin SMSM(d18:2/18:1) sphingolipids Sphingomyelin SMSM(d18:2/20:0) sphingolipids Sphingomyelin SMSM(d18:2/22:0) sphingolipids Sphingomyelin SMSM(d18:2/23:0) sphingolipids Sphingomyelin SMSM(d18:2/24:0) sphingolipids Sphingomyelin SMSM(d19:1/24:1) sphingolipids Sphingomyelin SMPA(34:1) glycerophospholipids Phosphatidic acid PAPA(36:1) glycerophospholipids Phosphatidic acid PAPA(36:2) glycerophospholipids Phosphatidic acid PAPA(36:3) glycerophospholipids Phosphatidic acid PAPA(36:4) glycerophospholipids Phosphatidic acid PAPA(40:6) glycerophospholipids Phosphatidic acid PAPC(14:0_16:0) glycerophospholipids Phosphatidylcholine PCPC(14:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(14:0_22:6) glycerophospholipids Phosphatidylcholine PCPC(15-MHDA_18:1) glycerophospholipids Phosphatidylcholine PCPC(15-MHDA_18:2) glycerophospholipids Phosphatidylcholine PCPC(15-MHDA_20:4) glycerophospholipids Phosphatidylcholine PCPC(15-MHDA_22:6) glycerophospholipids Phosphatidylcholine PCPC(15:0_20:3) glycerophospholipids Phosphatidylcholine PCPC(15:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(15:0_22:6) glycerophospholipids Phosphatidylcholine PCPC(16:0_16:0) glycerophospholipids Phosphatidylcholine PCPC(16:0_18:0) glycerophospholipids Phosphatidylcholine PCPC(16:0_18:1) glycerophospholipids Phosphatidylcholine PCPC(16:0_18:2) glycerophospholipids Phosphatidylcholine PCPC(16:0_18:3) (a) glycerophospholipids Phosphatidylcholine PCPC(16:0_18:3) (b) glycerophospholipids Phosphatidylcholine PCPC(16:0_20:3) (a) glycerophospholipids Phosphatidylcholine PCPC(16:0_20:3) (b) glycerophospholipids Phosphatidylcholine PCPC(16:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(16:0_20:5) glycerophospholipids Phosphatidylcholine PCPC(16:0_22:6) glycerophospholipids Phosphatidylcholine PCPC(16:1_18:2) glycerophospholipids Phosphatidylcholine PCPC(16:1_20:4) glycerophospholipids Phosphatidylcholine PCPC(16:1_22:6) glycerophospholipids Phosphatidylcholine PC ### Page 4 PC(17:0_18:1) glycerophospholipids Phosphatidylcholine PCPC(17:0_18:2) glycerophospholipids Phosphatidylcholine PCPC(17:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(17:0_22:6) glycerophospholipids Phosphatidylcholine PCPC(17:1_18:2) glycerophospholipids Phosphatidylcholine PCPC(18:0_18:1) glycerophospholipids Phosphatidylcholine PCPC(18:0_18:2) glycerophospholipids Phosphatidylcholine PCPC(18:0_20:3) glycerophospholipids Phosphatidylcholine PCPC(18:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(18:0_22:4) glycerophospholipids Phosphatidylcholine PCPC(18:0_22:5) (n3) & PC(20:1_20:4) glycerophospholipids Phosphatidylcholine PCPC(18:0_22:5) (n6) glycerophospholipids Phosphatidylcholine PCPC(18:0_22:6) glycerophospholipids Phosphatidylcholine PCPC(18:1_18:1) glycerophospholipids Phosphatidylcholine PCPC(18:1_18:2) glycerophospholipids Phosphatidylcholine PCPC(18:1_20:3) glycerophospholipids Phosphatidylcholine PCPC(18:1_22:6) (a) glycerophospholipids Phosphatidylcholine PCPC(18:1_22:6) (b) glycerophospholipids Phosphatidylcholine PCPC(18:2_18:2) glycerophospholipids Phosphatidylcholine PCPC(18:2_20:5) glycerophospholipids Phosphatidylcholine PCPC(20:0_20:4) glycerophospholipids Phosphatidylcholine PCPC(28:0) glycerophospholipids Phosphatidylcholine PCPC(31:0) (a) glycerophospholipids Phosphatidylcholine PCPC(31:0) (b) glycerophospholipids Phosphatidylcholine PCPC(32:1) glycerophospholipids Phosphatidylcholine PCPC(32:2) glycerophospholipids Phosphatidylcholine PCPC(33:0) (a) glycerophospholipids Phosphatidylcholine PCPC(33:0) (b) glycerophospholipids Phosphatidylcholine PCPC(33:1) glycerophospholipids Phosphatidylcholine PCPC(33:2) glycerophospholipids Phosphatidylcholine PCPC(34:5) glycerophospholipids Phosphatidylcholine PCPC(35:5) glycerophospholipids Phosphatidylcholine PCPC(36:6) (a) glycerophospholipids Phosphatidylcholine PCPC(38:2) glycerophospholipids Phosphatidylcholine PCPC(38:4) (b) glycerophospholipids Phosphatidylcholine PCPC(38:5) (a) glycerophospholipids Phosphatidylcholine PCPC(38:5) (b) glycerophospholipids Phosphatidylcholine PCPC(38:6) (a) glycerophospholipids Phosphatidylcholine PCPC(38:7) (c) glycerophospholipids Phosphatidylcholine PCPC(39:5) (a) glycerophospholipids Phosphatidylcholine PCPC(39:5) (b) glycerophospholipids Phosphatidylcholine PCPC(40:7) (a) glycerophospholipids Phosphatidylcholine PCPC(40:8) glycerophospholipids Phosphatidylcholine PCPC(44:12) glycerophospholipids Phosphatidylcholine PCPC(O-16:0/16:0) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-16:0/20:3) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-16:0/20:4) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-16:0/22:6) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:0/18:1) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:0/18:2) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:0/20:4) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:0/22:6) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:1/18:1) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-18:1/18:2) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-32:1) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-32:2) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-34:1) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-34:2) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-34:4) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-35:4) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-36:0) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-36:5) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(O-38:5) glycerophospholipids Alkylphosphatidylcholine PC(O) ### Page 5 PC(O-40:5) glycerophospholipids Alkylphosphatidylcholine PC(O)PC(P-15:0/20:4) (a) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-15:0/20:4) (b) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/14:0) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/16:0) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/16:1) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/18:0) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/18:1) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/18:2) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/18:3) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/20:4) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/20:5) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-16:0/22:6) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-17:0/20:4) (a) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-17:0/20:4) (b) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:0/18:2) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:0/20:4) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:0/22:5) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:0/22:6) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:1/18:1) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-18:1/22:6) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-20:0/20:4) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-35:2) (a) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-35:2) (b) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-36:3) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-38:5) (a) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)PC(P-38:5) (b) glycerophospholipids Alkenylphosphatidylcholine (plasmal PC(P)LPC(14:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(14:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(15-MHDA) [sn1] [104_sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(15-MHDA) [sn1] & LPC(17:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(15-MHDA) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(15:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(15:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(16:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(16:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(16:1) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(16:1) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(17:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(17:1) (a) [sn1] [104_sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(17:1) [sn1] (a) & LPC(17:1) [sn2] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(17:1) [sn1] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(17:1) [sn2] (a) glycerophospholipids Lysophosphatidylcholine LPCLPC(18:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:1) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:1) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:2) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:2) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:3) (a) [sn1] [104_sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(18:3) [sn1] (a) & LPC(18:3) [sn2] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(18:3) [sn1] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(18:3) [sn2] (a) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:0) (a) [sn1] [104_sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(19:0) [sn1] (a) & LPC(19:0) [sn2] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:0) [sn1] (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:0) [sn2] (a) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:1) (a) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:1) (b) glycerophospholipids Lysophosphatidylcholine LPCLPC(19:1) (c) glycerophospholipids Lysophosphatidylcholine LPCLPC(20:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:1) [sn1] glycerophospholipids Lysophosphatidylcholine LPC ### Page 6 LPC(20:1) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:2) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:2) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:3) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:3) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:4) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:4) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:5) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(20:5) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:1) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:1) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:4) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:4) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:5) (n3) [sn1] [104_sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:5) [sn1] (n3) & LPC(22:5) [sn2] (n6) glycerophospholipids Lysophosphatidylcholine LPCLPC(22:5) [sn1] (n6) glycerophospholipids Lysophosphatidylcholine LPCLPC(22:5) [sn2] (n3) glycerophospholipids Lysophosphatidylcholine LPCLPC(22:6) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(22:6) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(24:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(24:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(26:0) [sn1] glycerophospholipids Lysophosphatidylcholine LPCLPC(26:0) [sn2] glycerophospholipids Lysophosphatidylcholine LPCLPC(O-16:0) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-18:0) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-18:1) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-20:0) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-20:1) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-22:0) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-22:1) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-24:0) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-24:1) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(O-24:2) glycerophospholipids Lysoalkylphosphatidylcholine (lysoplatLPC(O)LPC(P-16:0) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)LPC(P-17:0) (a) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)LPC(P-17:0) (b) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)LPC(P-18:0) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)LPC(P-18:1) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)LPC(P-20:0) glycerophospholipids Lysoalkenylphosphatidylcholine (pla LPC(P)PE(15-MHDA_18:1) glycerophospholipids Phosphatidylethanolamine PEPE(15-MHDA_18:2) glycerophospholipids Phosphatidylethanolamine PEPE(15-MHDA_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(15-MHDA_22:6) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_16:0) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_16:1) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_18:1) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_18:2) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_18:3) (a) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_18:3) (b) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_20:3) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_20:5) glycerophospholipids Phosphatidylethanolamine PEPE(16:0_22:6) glycerophospholipids Phosphatidylethanolamine PEPE(16:1_18:2) glycerophospholipids Phosphatidylethanolamine PEPE(16:1_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(17:0_18:1) glycerophospholipids Phosphatidylethanolamine PEPE(17:0_18:2) glycerophospholipids Phosphatidylethanolamine PEPE(17:0_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(17:0_22:6) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_18:1) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_18:2) glycerophospholipids Phosphatidylethanolamine PE ### Page 7 PE(18:0_20:3) (a) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_20:3) (b) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_22:4) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_22:5) (n3) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_22:5) (n6) glycerophospholipids Phosphatidylethanolamine PEPE(18:0_22:6) glycerophospholipids Phosphatidylethanolamine PEPE(18:1_18:1) glycerophospholipids Phosphatidylethanolamine PEPE(18:1_18:2) glycerophospholipids Phosphatidylethanolamine PEPE(18:1_22:6) (a) glycerophospholipids Phosphatidylethanolamine PEPE(18:1_22:6) (b) glycerophospholipids Phosphatidylethanolamine PEPE(20:0_20:4) glycerophospholipids Phosphatidylethanolamine PEPE(36:0) glycerophospholipids Phosphatidylethanolamine PEPE(38:5) (a) glycerophospholipids Phosphatidylethanolamine PEPE(38:5) (b) glycerophospholipids Phosphatidylethanolamine PEPE(O-16:0/18:2) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-16:0/20:3) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-16:0/20:4) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-16:0/22:4) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-16:0/22:6) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-18:0/20:4) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-18:0/22:5) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-18:0/22:6) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-18:1/18:2) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-18:1/22:6) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-34:1) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-36:5) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-38:5) (a) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(O-38:5) (b) glycerophospholipids Alkylphosphatidylethanolamine PE(O)PE(P-15:0/20:4) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-15:0/20:4) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-15:0/22:6) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-15:0/22:6) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/18:1) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/18:2) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/18:3) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/20:3) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/20:3) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/20:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/20:5) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/22:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/22:5) (n3) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/22:5) (n6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-16:0/22:6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-17:0/20:4) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-17:0/20:4) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-17:0/22:6) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-17:0/22:6) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/18:1) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/18:2) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/18:3) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/20:3) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/20:3) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/20:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/20:5) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/22:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/22:5) (n3) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/22:5) (n6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:0/22:6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/18:1) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/18:1) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/18:2) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/18:2) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P) ### Page 8 PE(P-18:1/18:3) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:3) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:3) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:4) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:4) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:5) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/20:5) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/22:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/22:5) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/22:5) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/22:6) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-18:1/22:6) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-19:0/20:4) (a) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-19:0/20:4) (b) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:0/18:1) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:0/18:2) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:0/20:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:0/22:6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:1/20:4) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)PE(P-20:1/22:6) glycerophospholipids Alkenylphosphatidylethanolamine (p PE(P)LPE(16:0) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(16:0) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:0) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:0) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:1) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:1) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:2) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(18:2) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(20:4) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(20:4) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(22:6) [sn1] glycerophospholipids Lysophosphatidylethanolamine LPELPE(22:6) [sn2] glycerophospholipids Lysophosphatidylethanolamine LPELPE(P-16:0) glycerophospholipids LysoalkenylphosphatidylethanolaminLPE(P)LPE(P-18:0) glycerophospholipids LysoalkenylphosphatidylethanolaminLPE(P)LPE(P-18:1) glycerophospholipids LysoalkenylphosphatidylethanolaminLPE(P)LPE(P-20:0) glycerophospholipids LysoalkenylphosphatidylethanolaminLPE(P)PI(38:5) (b) glycerophospholipids Phosphatidylinositol PIPI(15-MHDA_18:1) & PI(17:0_18:1) glycerophospholipids Phosphatidylinositol PIPI(15-MHDA_18:2) & PI(17:0_18:2) glycerophospholipids Phosphatidylinositol PIPI(15-MHDA_20:4) & PI(17:0_20:4) glycerophospholipids Phosphatidylinositol PIPI(16:0_16:1) glycerophospholipids Phosphatidylinositol PIPI(16:0_20:3) (a) glycerophospholipids Phosphatidylinositol PIPI(16:0_20:3) (b) glycerophospholipids Phosphatidylinositol PIPI(16:0_20:4) glycerophospholipids Phosphatidylinositol PIPI(16:0/16:0) glycerophospholipids Phosphatidylinositol PIPI(18:0_18:1) glycerophospholipids Phosphatidylinositol PIPI(18:0_20:2) glycerophospholipids Phosphatidylinositol PIPI(18:0_20:3) (a) glycerophospholipids Phosphatidylinositol PIPI(18:0_20:3) (b) glycerophospholipids Phosphatidylinositol PIPI(18:0_20:4) glycerophospholipids Phosphatidylinositol PIPI(18:0_22:4) glycerophospholipids Phosphatidylinositol PIPI(18:0_22:5) (n3) glycerophospholipids Phosphatidylinositol PIPI(18:0_22:5) (n6) glycerophospholipids Phosphatidylinositol PIPI(18:0_22:6) glycerophospholipids Phosphatidylinositol PIPI(18:1_18:2) glycerophospholipids Phosphatidylinositol PIPI(20:0_20:4) glycerophospholipids Phosphatidylinositol PIPI(34:0) glycerophospholipids Phosphatidylinositol PIPI(34:1) glycerophospholipids Phosphatidylinositol PIPI(36:2) glycerophospholipids Phosphatidylinositol PIPI(37:6) glycerophospholipids Phosphatidylinositol PIPI(38:5) (a) glycerophospholipids Phosphatidylinositol PIPI(38:6) glycerophospholipids Phosphatidylinositol PIPI(39:6) glycerophospholipids Phosphatidylinositol PI ### Page 9 PIP1(38:4) glycerophospholipids Phosphatidylinositol monophosphatePIP1LPI(18:0) [sn1] glycerophospholipids Lysophosphatidylinositol LPILPI(18:0) [sn2] glycerophospholipids Lysophosphatidylinositol LPILPI(18:1) [sn1] glycerophospholipids Lysophosphatidylinositol LPILPI(18:1) [sn2] glycerophospholipids Lysophosphatidylinositol LPILPI(18:2) [sn1] glycerophospholipids Lysophosphatidylinositol LPILPI(18:2) [sn2] glycerophospholipids Lysophosphatidylinositol LPILPI(20:4) [sn1] glycerophospholipids Lysophosphatidylinositol LPILPI(20:4) [sn2] glycerophospholipids Lysophosphatidylinositol LPIPS(36:1) glycerophospholipids Phosphatidylserine PSPS(36:2) glycerophospholipids Phosphatidylserine PSPS(38:3) glycerophospholipids Phosphatidylserine PSPS(38:4) glycerophospholipids Phosphatidylserine PSPS(40:5) glycerophospholipids Phosphatidylserine PSPS(40:6) glycerophospholipids Phosphatidylserine PSPG(34:1) glycerophospholipids Phosphatidylglycerol PGPG(36:1) glycerophospholipids Phosphatidylglycerol PGPG(36:2) glycerophospholipids Phosphatidylglycerol PGCE(14:0) Neutral/Other Cholesteryl ester CECE(15:0) Neutral/Other Cholesteryl ester CECE(16:0) Neutral/Other Cholesteryl ester CECE(16:1) Neutral/Other Cholesteryl ester CECE(16:2) Neutral/Other Cholesteryl ester CECE(17:0) Neutral/Other Cholesteryl ester CECE(17:1) Neutral/Other Cholesteryl ester CECE(18:0) Neutral/Other Cholesteryl ester CECE(18:1) Neutral/Other Cholesteryl ester CECE(18:2) Neutral/Other Cholesteryl ester CECE(18:3) Neutral/Other Cholesteryl ester CECE(20:0) Neutral/Other Cholesteryl ester CECE(20:1) Neutral/Other Cholesteryl ester CECE(20:2) Neutral/Other Cholesteryl ester CECE(20:3) Neutral/Other Cholesteryl ester CECE(20:4) Neutral/Other Cholesteryl ester CECE(20:5) Neutral/Other Cholesteryl ester CECE(22:0) Neutral/Other Cholesteryl ester CECE(22:1) Neutral/Other Cholesteryl ester CECE(22:4) Neutral/Other Cholesteryl ester CECE(22:5) Neutral/Other Cholesteryl ester CECE(22:6) Neutral/Other Cholesteryl ester CECE(24:0) Neutral/Other Cholesteryl ester CECE(24:1) Neutral/Other Cholesteryl ester CECE(24:4) Neutral/Other Cholesteryl ester CECE(24:5) Neutral/Other Cholesteryl ester CECE(24:6) Neutral/Other Cholesteryl ester CECOH Neutral/Other Free Cholesterol COHDE(16:0) Neutral/Other Dehydrocholesterol ester DEDE(18:1) Neutral/Other Dehydrocholesterol ester DEDE(18:2) Neutral/Other Dehydrocholesterol ester DEDE(20:4) Neutral/Other Dehydrocholesterol ester DEDE(20:5) Neutral/Other Dehydrocholesterol ester DEDE(22:6) Neutral/Other Dehydrocholesterol ester DEdeDE(18:2) Neutral/Other Dehydrodemosterol ester deDEdeDE(20:4) Neutral/Other Dehydrodemosterol ester deDEmethyl-CE(18:0) Neutral/Other Methyl-cholesteryl ester methyl-CEmethyl-CE(18:1) Neutral/Other Methyl-cholesteryl ester methyl-CEmethyl-CE(18:2) Neutral/Other Methyl-cholesteryl ester methyl-CEmethyl-CE(20:4) Neutral/Other Methyl-cholesteryl ester methyl-CEmethyl-CE(22:6) Neutral/Other Methyl-cholesteryl ester methyl-CEmethyl-DE(18:1) Neutral/Other Methyl-dehydrocholesteryl ester methyl-DEmethyl-DE(18:2) Neutral/Other Methyl-dehydrocholesteryl ester methyl-DEdimethyl-CE(18:1) Neutral/Other Dimethyl-cholesteryl ester dimethyl-CEdimethyl-CE(18:2) Neutral/Other Dimethyl-cholesteryl ester dimethyl-CE ### Page 10 dimethyl-CE(20:4) Neutral/Other Dimethyl-cholesteryl ester dimethyl-CEdimethyl-CE(22:6) Neutral/Other Dimethyl-cholesteryl ester dimethyl-CEFA(14:0) Neutral/Other Free fatty acid FFAFA(16:0) Neutral/Other Free fatty acid FFAFA(16:1) Neutral/Other Free fatty acid FFAFA(17:0) Neutral/Other Free fatty acid FFAFA(17:1) Neutral/Other Free fatty acid FFAFA(18:0) Neutral/Other Free fatty acid FFAFA(18:1) Neutral/Other Free fatty acid FFAFA(18:2) Neutral/Other Free fatty acid FFAFA(18:3) Neutral/Other Free fatty acid FFAFA(20:2) Neutral/Other Free fatty acid FFAFA(20:3) Neutral/Other Free fatty acid FFAFA(20:4) Neutral/Other Free fatty acid FFAFA(20:5) Neutral/Other Free fatty acid FFAFA(22:4) Neutral/Other Free fatty acid FFAFA(22:5) Neutral/Other Free fatty acid FFAFA(22:6) Neutral/Other Free fatty acid FFAAC(12:0) Neutral/Other Acylcarnitine ACAC(12:1) Neutral/Other Acylcarnitine ACAC(13:0) Neutral/Other Acylcarnitine ACAC(14:0) Neutral/Other Acylcarnitine ACAC(14:1) Neutral/Other Acylcarnitine ACAC(14:2) Neutral/Other Acylcarnitine ACAC(15:0) (a) Neutral/Other Acylcarnitine ACAC(15:0) (b) Neutral/Other Acylcarnitine ACAC(16:0) Neutral/Other Acylcarnitine ACAC(16:1) Neutral/Other Acylcarnitine ACAC(17:0) (a) Neutral/Other Acylcarnitine ACAC(17:0) (b) Neutral/Other Acylcarnitine ACAC(18:0) Neutral/Other Acylcarnitine ACAC(18:1) Neutral/Other Acylcarnitine ACAC(18:2) Neutral/Other Acylcarnitine ACAC(18:3) Neutral/Other Acylcarnitine ACAC(20:3) (a) Neutral/Other Acylcarnitine ACAC(20:3) (b) Neutral/Other Acylcarnitine ACAC(20:4) Neutral/Other Acylcarnitine ACAC(20:5) Neutral/Other Acylcarnitine ACAC(22:5) Neutral/Other Acylcarnitine ACAC(22:6) Neutral/Other Acylcarnitine ACAC(24:0) Neutral/Other Acylcarnitine ACAC(24:1) Neutral/Other Acylcarnitine ACAC(26:0) Neutral/Other Acylcarnitine ACAC(26:1) Neutral/Other Acylcarnitine ACAC(14:0)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(14:1)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(16:0)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(16:1)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(18:0)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(18:1)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(20:3)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(22:5)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHAC(24:1)-OH Neutral/Other Hydroxylated acylcarnitine AC-OHCA Neutral/Other Bile acid BAdxCA Neutral/Other Bile acid BADG(14:0_16:0) Neutral/Other Diacylglycerol DGDG(14:0_18:2) Neutral/Other Diacylglycerol DGDG(16:0_16:0) Neutral/Other Diacylglycerol DGDG(16:0_16:1) Neutral/Other Diacylglycerol DGDG(16:0_18:1) Neutral/Other Diacylglycerol DGDG(16:0_18:2) Neutral/Other Diacylglycerol DGDG(16:0_20:4) Neutral/Other Diacylglycerol DGDG(16:0_22:5) Neutral/Other Diacylglycerol DG ### Page 11 DG(16:0_22:6) Neutral/Other Diacylglycerol DGDG(16:1_18:1) Neutral/Other Diacylglycerol DGDG(18:0_18:1) Neutral/Other Diacylglycerol DGDG(18:0_18:2) Neutral/Other Diacylglycerol DGDG(18:0_20:4) Neutral/Other Diacylglycerol DGDG(18:1_18:1) Neutral/Other Diacylglycerol DGDG(18:1_18:2) Neutral/Other Diacylglycerol DGDG(18:1_18:3) Neutral/Other Diacylglycerol DGDG(18:1_20:3) Neutral/Other Diacylglycerol DGDG(18:1_20:4) Neutral/Other Diacylglycerol DGDG(18:1_20:5) Neutral/Other Diacylglycerol DGDG(18:1_22:5) Neutral/Other Diacylglycerol DGDG(18:1_22:6) Neutral/Other Diacylglycerol DGDG(18:2_18:2) Neutral/Other Diacylglycerol DGDG(18:2_20:4) Neutral/Other Diacylglycerol DGDG(18:2_22:6) Neutral/Other Diacylglycerol DGTG(48:0) [NL-16:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:0) [NL-18:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:1) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:1) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:2) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:2) [NL-14:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:2) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:2) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:3) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:3) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(48:3) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(49:1) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(49:1) [NL-17:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:0) [NL-18:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:1) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:1) [NL-16:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:1) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:2) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:2) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:2) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:2) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:3) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:3) [NL-14:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:3) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:3) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:3) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:4) [NL-14:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:4) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(50:4) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(51:0) [NL-16:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(51:1) [NL-17:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(51:2) [NL-15:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(51:2) [NL-17:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(51:2) [NL-17:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:1) [NL-18:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:1) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:2) [NL-16:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:2) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:3) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:3) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:4) [NL-16:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:4) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:4) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:5) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:5) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(52:5) [NL-20:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(53:2) [NL-17:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL] ### Page 12 TG(53:2) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:0) [NL-18:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:1) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:2) [NL-18:0] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:2) [NL-20:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:3) [NL-18:1] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:3) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:4) [NL-18:2] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:4) [NL-20:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:5) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:5) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:6) [NL-18:3] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:6) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:6) [NL-20:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:6) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:7) [NL-20:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(54:7) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:6) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:6) [NL-22:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:7) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:7) [NL-20:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:7) [NL-22:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:7) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:8) [NL-20:4] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:8) [NL-20:5] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:8) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(56:9) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(58:10) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(58:8) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(58:9) [NL-22:6] Neutral/Other Triacylglycerol (neutral loss, for assocTG [NL]TG(O-50:1) [NL-15:0] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:1) [NL-16:0] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:1) [NL-17:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:1) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:2) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:2) [NL-18:2] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-50:3) [NL-18:2] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:0) [NL-16:0] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:1) [NL-16:0] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:1) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:2) [NL-16:0] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:2) [NL-17:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-52:2) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:2) [NL-17:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:2) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:3) [NL-17:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:3) [NL-18:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:4) [NL-17:1] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]TG(O-54:4) [NL-18:2] Neutral/Other Alkyldiacylglycerol (neutral loss, for aTG(O) [NL]Ubiquinone Neutral/Other Ubiquinone UbiquinoneCE(18:2) [+OH] Neutral/Other Oxidised lipids OxSpeciesCE(20:4) [+OH] Neutral/Other Oxidised lipids OxSpeciesCE(22:6) [+OH] Neutral/Other Oxidised lipids OxSpeciesLPC(18:2) [+OH] Neutral/Other Oxidised lipids OxSpeciesLPC(20:4) [+OH] Neutral/Other Oxidised lipids OxSpeciesLPC(22:6) [+OH] Neutral/Other Oxidised lipids OxSpeciesPC(34:2) [+OH] Neutral/Other Oxidised lipids OxSpeciesPC(36:4) [+OH] Neutral/Other Oxidised lipids OxSpecies ### Page 13 Supplementary Table 2. Association of lipid species with baseline A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid Species Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)SM(41:0) -0.148 -0.224 -0.073 0.000 0.034 -0.054 -0.120 0.012 0.110 0.333 0.095 0.045 0.146 0.000 0.007 0.087 0.016 0.157 0.016 0.110LPC(O-24:1) 0.134 0.065 0.202 0.000 0.034 0.053 -0.009 0.115 0.095 0.311 -0.033 -0.081 0.016 0.186 0.484 -0.113 -0.177 -0.049 0.001 0.025LPC(O-24:2) 0.134 0.067 0.202 0.000 0.034 0.052 -0.009 0.114 0.095 0.311 -0.050 -0.097 -0.004 0.034 0.209 -0.053 -0.117 0.010 0.098 0.282SM(d18:1/23:0) & SM(d17:1/24:0) -0.163 -0.254 -0.071 0.001 0.044 -0.046 -0.126 0.034 0.256 0.492 0.113 0.051 0.175 0.000 0.009 0.063 -0.022 0.149 0.144 0.350LPC(18:2) [sn1] 0.133 0.061 0.204 0.000 0.044 0.069 0.005 0.132 0.035 0.196 0.009 -0.040 0.057 0.722 0.887 -0.012 -0.079 0.054 0.717 0.845LPC(18:2) [sn2] 0.127 0.056 0.198 0.000 0.044 0.052 -0.012 0.116 0.108 0.331 0.013 -0.034 0.060 0.587 0.811 -0.005 -0.071 0.062 0.893 0.945LPC(19:1) (b) 0.121 0.054 0.189 0.000 0.044 0.070 0.009 0.131 0.025 0.169 -0.018 -0.067 0.031 0.465 0.732 -0.087 -0.150 -0.023 0.008 0.078LPC(O-22:1) 0.124 0.057 0.191 0.000 0.044 0.059 -0.002 0.120 0.058 0.254 -0.029 -0.079 0.020 0.246 0.562 -0.106 -0.169 -0.043 0.001 0.028PE(O-18:0/22:6) -0.130 -0.202 -0.058 0.000 0.044 -0.102 -0.167 -0.038 0.002 0.042 0.073 0.024 0.121 0.003 0.048 0.038 -0.029 0.105 0.265 0.473PE(P-20:1/20:4) -0.114 -0.180 -0.047 0.001 0.060 -0.075 -0.134 -0.016 0.012 0.110 0.044 0.000 0.088 0.050 0.252 0.036 -0.026 0.097 0.253 0.461LPC(20:1) [sn1] 0.113 0.044 0.181 0.001 0.084 0.021 -0.041 0.082 0.516 0.709 0.023 -0.027 0.073 0.359 0.668 -0.033 -0.098 0.031 0.307 0.532LPC(20:2) [sn1] 0.113 0.044 0.182 0.001 0.084 0.053 -0.009 0.116 0.092 0.310 0.012 -0.038 0.062 0.629 0.829 -0.022 -0.087 0.043 0.501 0.701HexCer(d18:1/24:1) 0.116 0.045 0.187 0.001 0.085 0.001 -0.063 0.064 0.981 0.985 -0.009 -0.056 0.038 0.703 0.875 -0.051 -0.117 0.016 0.134 0.334Hex2Cer(d18:1/16:0) 0.113 0.039 0.187 0.003 0.088 0.056 -0.009 0.122 0.094 0.310 -0.020 -0.070 0.030 0.434 0.715 -0.077 -0.146 -0.007 0.030 0.158Cer(d18:2/24:1) 0.113 0.040 0.186 0.002 0.088 0.018 -0.049 0.084 0.600 0.778 -0.043 -0.094 0.007 0.092 0.346 -0.093 -0.162 -0.025 0.008 0.078PC(16:1_18:2) 0.138 0.050 0.227 0.002 0.088 0.128 0.049 0.206 0.001 0.037 -0.078 -0.138 -0.017 0.012 0.114 -0.141 -0.222 -0.059 0.001 0.027LPC(18:1) [sn1] 0.113 0.042 0.183 0.002 0.088 0.060 -0.003 0.122 0.062 0.264 -0.021 -0.075 0.033 0.452 0.728 -0.081 -0.146 -0.015 0.016 0.110LPC(18:1) [sn2] 0.109 0.038 0.181 0.003 0.088 0.061 -0.001 0.124 0.056 0.254 -0.020 -0.072 0.033 0.461 0.730 -0.058 -0.124 0.008 0.085 0.270LPC(19:1) (c) 0.108 0.039 0.177 0.002 0.088 0.055 -0.007 0.117 0.080 0.292 -0.006 -0.051 0.039 0.795 0.914 -0.012 -0.076 0.052 0.708 0.841LPC(O-20:1) 0.100 0.035 0.165 0.003 0.088 0.058 -0.002 0.117 0.057 0.254 -0.047 -0.101 0.007 0.086 0.332 -0.124 -0.186 -0.062 0.000 0.011LPC(16:1) [sn1] 0.114 0.042 0.185 0.002 0.088 0.110 0.048 0.173 0.001 0.026 -0.075 -0.127 -0.024 0.004 0.057 -0.121 -0.186 -0.055 0.000 0.017PE(O-18:0/22:5) -0.111 -0.181 -0.041 0.002 0.088 0.003 -0.060 0.067 0.921 0.964 0.008 -0.040 0.056 0.741 0.892 0.016 -0.049 0.082 0.623 0.800PE(O-38:5) (b) -0.110 -0.181 -0.039 0.003 0.088 -0.046 -0.109 0.018 0.158 0.395 0.019 -0.029 0.067 0.430 0.714 0.019 -0.047 0.084 0.579 0.760DE(20:4) -0.149 -0.244 -0.053 0.002 0.088 -0.035 -0.120 0.050 0.417 0.620 0.035 -0.026 0.096 0.260 0.577 0.041 -0.047 0.128 0.362 0.590LPC(19:1) (a) 0.102 0.035 0.170 0.003 0.093 0.058 -0.003 0.119 0.063 0.268 0.002 -0.046 0.049 0.951 0.979 -0.053 -0.117 0.010 0.101 0.284LPE(18:2) [sn2] 0.103 0.034 0.172 0.003 0.097 0.085 0.023 0.147 0.007 0.093 -0.035 -0.082 0.012 0.140 0.424 -0.038 -0.103 0.026 0.244 0.455Hex2Cer(d18:2/24:1) 0.113 0.036 0.191 0.004 0.102 0.027 -0.041 0.096 0.433 0.633 -0.004 -0.054 0.046 0.878 0.953 -0.014 -0.086 0.057 0.694 0.840LPC(18:3) [sn1] (a) & LPC(18:3) [sn2] (b) 0.098 0.031 0.165 0.004 0.102 0.070 0.010 0.130 0.022 0.154 -0.018 -0.062 0.027 0.437 0.718 -0.019 -0.081 0.044 0.553 0.742LPC(18:3) [sn2] (a) 0.098 0.031 0.165 0.004 0.102 0.086 0.026 0.146 0.005 0.077 -0.021 -0.067 0.024 0.357 0.667 -0.042 -0.105 0.021 0.190 0.395LPC(19:0) [sn1] (b) 0.106 0.034 0.177 0.004 0.102 0.037 -0.027 0.101 0.254 0.492 0.022 -0.030 0.074 0.399 0.691 -0.013 -0.079 0.054 0.705 0.840PE(O-18:0/20:4) -0.098 -0.165 -0.031 0.004 0.102 -0.017 -0.078 0.044 0.581 0.765 0.049 0.004 0.095 0.035 0.210 -0.002 -0.065 0.061 0.947 0.973LPE(18:2) [sn1] 0.100 0.032 0.169 0.004 0.102 0.079 0.018 0.141 0.012 0.107 -0.038 -0.085 0.009 0.112 0.381 -0.038 -0.103 0.027 0.250 0.461SM(d18:0/22:0) -0.104 -0.177 -0.031 0.005 0.109 -0.051 -0.116 0.013 0.119 0.346 0.076 0.027 0.125 0.002 0.038 0.056 -0.011 0.124 0.102 0.287LPC(18:3) (a) [sn1] [104_sn1] 0.095 0.029 0.162 0.005 0.109 0.077 0.017 0.136 0.011 0.106 -0.015 -0.060 0.029 0.494 0.749 -0.024 -0.086 0.038 0.446 0.661LPC(17:1) (a) [sn1] [104_sn1] 0.097 0.029 0.165 0.005 0.109 0.082 0.021 0.143 0.008 0.096 -0.025 -0.074 0.024 0.323 0.635 -0.099 -0.162 -0.036 0.002 0.041LPC(17:1) [sn1] (a) & LPC(17:1) [sn2] (b) 0.097 0.029 0.165 0.005 0.109 0.065 0.005 0.126 0.035 0.196 -0.028 -0.074 0.017 0.223 0.534 -0.082 -0.144 -0.019 0.011 0.089LPC(P-18:1) 0.097 0.028 0.166 0.006 0.114 0.069 0.008 0.129 0.027 0.175 -0.022 -0.079 0.035 0.458 0.730 -0.097 -0.159 -0.034 0.003 0.042TG(50:3) [NL-14:0] 0.121 0.035 0.207 0.006 0.114 0.107 0.024 0.190 0.011 0.106 -0.079 -0.143 -0.015 0.016 0.137 -0.083 -0.168 0.002 0.056 0.218TG(54:6) [NL-22:6] -0.101 -0.173 -0.029 0.006 0.114 -0.086 -0.151 -0.021 0.009 0.099 0.022 -0.026 0.071 0.372 0.673 0.020 -0.048 0.088 0.563 0.750LPC(19:0) [sn1] (a) & LPC(19:0) [sn2] (b) 0.100 0.028 0.171 0.007 0.119 0.018 -0.047 0.082 0.592 0.773 0.024 -0.025 0.074 0.336 0.646 -0.002 -0.068 0.064 0.950 0.973TG(56:7) [NL-22:6] -0.097 -0.167 -0.027 0.007 0.119 -0.093 -0.155 -0.031 0.003 0.060 0.046 -0.001 0.093 0.053 0.259 0.021 -0.044 0.087 0.517 0.717GM3(d18:1/24:1) 0.104 0.029 0.178 0.007 0.120 0.015 -0.052 0.081 0.670 0.826 -0.034 -0.087 0.020 0.214 0.524 -0.143 -0.214 -0.073 0.000 0.011LPC(O-18:1) 0.089 0.025 0.154 0.007 0.121 0.044 -0.016 0.103 0.153 0.385 0.011 -0.042 0.065 0.673 0.858 -0.079 -0.140 -0.017 0.013 0.096PE(P-15:0/22:6) (b) -0.095 -0.164 -0.026 0.007 0.123 -0.107 -0.168 -0.046 0.001 0.026 0.065 0.019 0.111 0.005 0.065 0.040 -0.024 0.103 0.220 0.427LPC(22:5) [sn1] (n3) & LPC(22:5) [sn2] (n6) 0.093 0.025 0.161 0.008 0.126 0.090 0.030 0.151 0.003 0.060 -0.060 -0.107 -0.013 0.012 0.114 -0.046 -0.109 0.017 0.151 0.358SM(44:1) -0.105 -0.182 -0.027 0.008 0.129 -0.062 -0.131 0.007 0.078 0.289 0.101 0.050 0.152 0.000 0.004 0.113 0.041 0.185 0.002 0.041PE(P-19:0/20:4) (a) -0.091 -0.158 -0.024 0.008 0.129 -0.051 -0.111 0.008 0.092 0.310 0.040 -0.004 0.085 0.078 0.317 0.015 -0.047 0.076 0.641 0.810LPC(18:3) [sn1] (b) 0.091 0.023 0.158 0.009 0.135 0.079 0.019 0.139 0.010 0.100 -0.015 -0.060 0.029 0.503 0.757 -0.029 -0.092 0.034 0.374 0.603Cer(d17:1/24:1) 0.095 0.024 0.167 0.009 0.139 0.051 -0.014 0.115 0.124 0.353 -0.025 -0.073 0.023 0.305 0.622 -0.079 -0.145 -0.013 0.020 0.128SM(d18:1/24:0) -0.112 -0.196 -0.027 0.009 0.139 -0.049 -0.125 0.026 0.201 0.443 0.120 0.064 0.176 0.000 0.001 0.126 0.047 0.204 0.002 0.041LPC(P-18:0) 0.091 0.022 0.160 0.009 0.139 0.038 -0.023 0.100 0.222 0.465 -0.019 -0.071 0.033 0.476 0.737 -0.070 -0.135 -0.006 0.031 0.162Cer(d18:1/24:1) 0.095 0.022 0.167 0.011 0.150 0.034 -0.032 0.101 0.308 0.541 -0.044 -0.094 0.007 0.090 0.340 -0.138 -0.207 -0.070 0.000 0.011LPC(O-20:0) 0.089 0.021 0.157 0.011 0.150 0.049 -0.013 0.111 0.120 0.346 -0.028 -0.077 0.021 0.268 0.588 -0.085 -0.150 -0.021 0.009 0.087DE(20:5) -0.101 -0.179 -0.023 0.011 0.152 -0.125 -0.195 -0.056 0.000 0.021 0.057 0.006 0.108 0.029 0.192 0.078 0.006 0.149 0.033 0.169LPE(16:0) [sn2] 0.095 0.022 0.168 0.011 0.152 0.042 -0.024 0.108 0.215 0.456 -0.046 -0.098 0.006 0.081 0.324 -0.073 -0.142 -0.004 0.039 0.184DE(22:6) -0.103 -0.183 -0.023 0.012 0.156 -0.108 -0.176 -0.040 0.002 0.042 0.057 0.006 0.107 0.028 0.185 0.061 -0.010 0.132 0.090 0.277PE(P-20:1/22:6) -0.087 -0.155 -0.019 0.012 0.158 -0.101 -0.161 -0.041 0.001 0.034 0.046 0.001 0.091 0.047 0.243 0.032 -0.030 0.095 0.311 0.536PC(18:2_18:2) 0.100 0.020 0.181 0.014 0.159 0.036 -0.034 0.106 0.316 0.547 0.049 -0.003 0.101 0.064 0.286 0.043 -0.031 0.116 0.252 0.461LPC(22:5) (n3) [sn1] [104_sn1] 0.085 0.017 0.152 0.014 0.159 0.072 0.012 0.132 0.019 0.141 -0.059 -0.104 -0.013 0.012 0.114 -0.030 -0.093 0.033 0.346 0.572LPC(20:2) [sn2] 0.089 0.018 0.159 0.014 0.159 0.029 -0.034 0.092 0.370 0.583 0.013 -0.036 0.061 0.605 0.817 0.010 -0.056 0.076 0.777 0.878LPC(16:1) [sn2] 0.092 0.019 0.165 0.013 0.159 0.098 0.034 0.161 0.003 0.055 -0.065 -0.116 -0.015 0.010 0.107 -0.105 -0.172 -0.038 0.002 0.041LPC(P-16:0) 0.085 0.017 0.152 0.014 0.159 0.038 -0.022 0.098 0.215 0.456 0.004 -0.046 0.054 0.881 0.953 -0.057 -0.119 0.006 0.074 0.259LPC(17:1) [sn2] (a) 0.087 0.018 0.155 0.013 0.159 0.062 0.001 0.123 0.045 0.222 -0.022 -0.068 0.025 0.360 0.668 -0.067 -0.130 -0.004 0.036 0.178PE(P-19:0/20:4) (b) -0.086 -0.154 -0.018 0.013 0.159 -0.060 -0.120 0.000 0.050 0.237 0.050 0.006 0.095 0.028 0.185 0.037 -0.025 0.099 0.242 0.453LPE(20:4) [sn1] 0.089 0.018 0.160 0.014 0.159 0.086 0.023 0.149 0.008 0.095 -0.062 -0.109 -0.015 0.009 0.100 -0.098 -0.164 -0.032 0.004 0.051TG(O-54:2) [NL-18:1] -0.090 -0.162 -0.018 0.014 0.159 -0.044 -0.108 0.021 0.182 0.425 0.118 0.067 0.169 0.000 0.000 0.023 -0.044 0.091 0.493 0.696LPC(18:2) [+OH] 0.085 0.018 0.152 0.013 0.159 0.040 -0.020 0.100 0.188 0.426 0.003 -0.042 0.048 0.882 0.953 0.001 -0.061 0.063 0.968 0.980PE(P-18:0/22:6) -0.090 -0.162 -0.018 0.015 0.162 -0.130 -0.194 -0.065 0.000 0.016 0.091 0.043 0.139 0.000 0.006 0.049 -0.018 0.115 0.150 0.358PE(P-15:0/20:4) (b) -0.084 -0.151 -0.016 0.015 0.162 -0.014 -0.074 0.045 0.635 0.795 0.054 0.010 0.098 0.016 0.137 0.044 -0.017 0.105 0.157 0.361LPC(O-18:0) 0.082 0.015 0.149 0.016 0.167 0.060 -0.001 0.122 0.053 0.244 -0.038 -0.091 0.015 0.164 0.457 -0.106 -0.170 -0.042 0.001 0.029LPC(20:0) [sn1] 0.089 0.016 0.161 0.016 0.167 -0.003 -0.068 0.062 0.929 0.968 0.024 -0.024 0.073 0.328 0.641 0.008 -0.059 0.075 0.816 0.906LPC(20:1) [sn2] 0.083 0.015 0.150 0.016 0.167 0.016 -0.045 0.077 0.605 0.778 0.019 -0.029 0.067 0.439 0.718 -0.010 -0.073 0.054 0.767 0.874TG(54:6) [NL-18:3] 0.090 0.017 0.164 0.016 0.167 0.038 -0.030 0.106 0.270 0.506 -0.008 -0.060 0.044 0.763 0.900 -0.047 -0.117 0.024 0.192 0.397LPE(16:0) [sn1] 0.090 0.016 0.163 0.017 0.169 0.038 -0.028 0.104 0.256 0.492 -0.052 -0.103 -0.001 0.047 0.243 -0.077 -0.146 -0.008 0.029 0.154LPC(O-16:0) 0.080 0.014 0.146 0.017 0.170 0.043 -0.017 0.103 0.161 0.397 -0.010 -0.061 0.040 0.682 0.864 -0.088 -0.150 -0.025 0.006 0.065dhCer(d18:0/20:0) -0.085 -0.155 -0.014 0.018 0.177 -0.028 -0.090 0.034 0.375 0.585 0.017 -0.029 0.064 0.462 0.730 0.006 -0.059 0.070 0.866 0.928PC(17:1_18:2) 0.096 0.016 0.175 0.018 0.177 0.104 0.033 0.175 0.004 0.064 -0.011 -0.067 0.045 0.699 0.875 -0.108 -0.181 -0.034 0.004 0.056PE(P-18:0/20:4) -0.082 -0.150 -0.014 0.018 0.177 -0.041 -0.101 0.019 0.184 0.425 0.054 0.008 0.100 0.021 0.158 -0.014 -0.076 0.049 0.669 0.823Hex2Cer(d16:1/24:1) 0.084 0.014 0.154 0.019 0.183 0.036 -0.026 0.097 0.257 0.492 -0.014 -0.059 0.031 0.540 0.779 -0.047 -0.112 0.017 0.151 0.358PC(O-18:1/18:2) 0.092 0.015 0.170 0.020 0.186 0.046 -0.023 0.115 0.189 0.426 0.044 -0.009 0.096 0.106 0.368 -0.014 -0.085 0.058 0.711 0.841DG(16:0_22:6) -0.091 -0.168 -0.014 0.021 0.192 -0.111 -0.179 -0.043 0.001 0.037 0.028 -0.022 0.078 0.276 0.596 0.009 -0.062 0.079 0.812 0.902LPC(P-17:0) (a) 0.079 0.012 0.146 0.022 0.195 0.054 -0.006 0.114 0.075 0.286 -0.004 -0.052 0.043 0.865 0.946 -0.066 -0.128 -0.004 0.038 0.182TG(O-54:2) [NL-17:1] -0.080 -0.147 -0.012 0.021 0.195 -0.037 -0.098 0.024 0.231 0.475 0.132 0.086 0.179 0.000 0.000 0.014 -0.050 0.077 0.674 0.824LPC(O-24:0) 0.084 0.012 0.157 0.022 0.198 0.019 -0.045 0.084 0.557 0.744 -0.031 -0.079 0.016 0.199 0.502 -0.095 -0.162 -0.029 0.005 0.063Cer(d16:1/24:1) 0.086 0.012 0.159 0.023 0.199 0.047 -0.019 0.113 0.159 0.395 -0.038 -0.087 0.011 0.132 0.412 -0.091 -0.159 -0.023 0.008 0.082HexCer(d18:2/22:0) 0.084 0.010 0.158 0.025 0.207 0.023 -0.042 0.088 0.494 0.686 -0.001 -0.050 0.047 0.966 0.985 0.008 -0.059 0.076 0.811 0.902HexCer(d18:2/24:0) 0.087 0.011 0.162 0.024 0.207 0.005 -0.061 0.071 0.889 0.954 -0.006 -0.054 0.043 0.820 0.925 0.003 -0.064 0.071 0.926 0.960LPC(P-17:0) (b) 0.077 0.010 0.144 0.025 0.207 0.030 -0.030 0.090 0.325 0.559 0.010 -0.039 0.058 0.689 0.868 -0.062 -0.124 0.000 0.052 0.207LPC(22:1) [sn1] 0.079 0.010 0.148 0.025 0.207 -0.027 -0.090 0.036 0.397 0.606 -0.005 -0.053 0.042 0.823 0.925 -0.049 -0.114 0.016 0.136 0.338TG(54:1) [NL-18:1] -0.102 -0.191 -0.014 0.024 0.207 -0.023 -0.102 0.055 0.557 0.744 0.018 -0.042 0.078 0.552 0.783 -0.020 -0.104 0.064 0.641 0.810TG(50:3) [NL-18:2] 0.109 0.014 0.204 0.025 0.207 0.134 0.045 0.223 0.003 0.060 -0.120 -0.190 -0.050 0.001 0.019 -0.160 -0.252 -0.067 0.001 0.027TG(52:1) [NL-18:0] -0.107 -0.201 -0.014 0.025 0.207 -0.049 -0.133 0.035 0.254 0.492 -0.017 -0.081 0.047 0.609 0.819 -0.037 -0.127 0.053 0.419 0.640LPC(16:0) [sn2] 0.082 0.010 0.155 0.026 0.212 0.038 -0.027 0.103 0.253 0.492 -0.039 -0.090 0.013 0.142 0.426 -0.063 -0.131 0.005 0.068 0.249LPC(22:6) [+OH] 0.073 0.008 0.137 0.027 0.215 -0.015 -0.072 0.043 0.617 0.783 0.019 -0.023 0.061 0.383 0.678 0.042 -0.017 0.101 0.159 0.363LPC(20:0) [sn2] 0.081 0.009 0.154 0.027 0.215 -0.008 -0.073 0.056 0.801 0.912 0.023 -0.024 0.071 0.335 0.646 0.040 -0.026 0.107 0.234 0.444PE(O-18:1/22:6) -0.080 -0.151 -0.009 0.028 0.220 -0.121 -0.184 -0.057 0.000 0.016 0.101 0.053 0.148 0.000 0.002 0.050 -0.016 0.116 0.139 0.342PE(18:0_22:6) -0.094 -0.178 -0.010 0.029 0.222 -0.131 -0.206 -0.056 0.001 0.026 0.028 -0.029 0.084 0.334 0.646 0.027 -0.050 0.105 0.492 0.696PE(O-16:0/22:6) -0.080 -0.151 -0.008 0.029 0.222 -0.116 -0.179 -0.052 0.000 0.021 0.075 0.027 0.123 0.002 0.036 0.012 -0.054 0.078 0.718 0.845GM1(d18:1/16:0) 0.079 0.007 0.150 0.030 0.226 0.003 -0.059 0.065 0.921 0.964 -0.056 -0.103 -0.009 0.020 0.158 -0.085 -0.151 -0.020 0.011 0.089LPC(17:0) [sn1] 0.075 0.007 0.142 0.030 0.226 0.015 -0.045 0.076 0.621 0.783 0.009 -0.039 0.058 0.704 0.875 -0.053 -0.116 0.010 0.100 0.284DG(18:1_22:6) -0.081 -0.155 -0.008 0.030 0.226 -0.122 -0.186 -0.058 0.000 0.016 0.049 0.001 0.096 0.047 0.243 0.024 -0.043 0.092 0.478 0.689TG(50:4) [NL-14:0] 0.099 0.009 0.190 0.031 0.226 0.076 -0.009 0.160 0.078 0.289 -0.066 -0.131 -0.001 0.045 0.243 -0.099 -0.186 -0.012 0.027 0.152Cer(d18:2/22:0) 0.082 0.007 0.156 0.032 0.231 0.065 -0.002 0.132 0.056 0.254 -0.027 -0.078 0.024 0.304 0.620 -0.034 -0.103 0.035 0.338 0.568TG(52:1) [NL-18:1] -0.104 -0.198 -0.009 0.032 0.231 -0.032 -0.117 0.053 0.463 0.661 -0.006 -0.071 0.060 0.862 0.946 -0.035 -0.125 0.056 0.455 0.668AC(18:3) 0.071 0.006 0.135 0.033 0.232 0.041 -0.017 0.099 0.165 0.399 -0.027 -0.070 0.016 0.221 0.534 -0.029 -0.090 0.031 0.342 0.569PE(P-18:0/20:5) -0.078 -0.150 -0.006 0.033 0.235 -0.097 -0.162 -0.032 0.004 0.060 0.035 -0.013 0.083 0.156 0.446 0.058 -0.008 0.124 0.087 0.273Hex2Cer(d18:1/24:1) 0.083 0.006 0.161 0.034 0.237 0.014 -0.055 0.082 0.695 0.842 -0.014 -0.065 0.036 0.581 0.808 -0.013 -0.085 0.059 0.730 0.856LPC(22:5) [sn2] (n3) 0.075 0.005 0.145 0.035 0.237 0.059 -0.003 0.120 0.064 0.268 -0.060 -0.107 -0.013 0.012 0.114 -0.050 -0.115 0.014 0.128 0.329LPC(15-MHDA) [sn1] [104_sn1] 0.072 0.005 0.140 0.035 0.237 0.045 -0.016 0.105 0.147 0.381 -0.006 -0.054 0.041 0.792 0.913 -0.066 -0.129 -0.004 0.037 0.182LPE(20:4) [sn2] 0.077 0.005 0.148 0.035 0.237 0.079 0.016 0.142 0.014 0.116 -0.057 -0.105 -0.010 0.018 0.150 -0.104 -0.170 -0.038 0.002 0.041DG(16:0_16:0) -0.109 -0.210 -0.008 0.034 0.237 -0.026 -0.116 0.064 0.566 0.750 -0.014 -0.082 0.055 0.693 0.871 -0.073 -0.167 0.021 0.127 0.328TG(54:0) [NL-18:0] -0.084 -0.162 -0.006 0.035 0.237 0.007 -0.063 0.077 0.843 0.937 -0.001 -0.054 0.053 0.981 0.992 -0.051 -0.125 0.023 0.176 0.381LPC(15-MHDA) [sn2] 0.072 0.005 0.139 0.036 0.239 0.026 -0.034 0.086 0.390 0.599 -0.009 -0.054 0.037 0.703 0.875 -0.048 -0.110 0.014 0.128 0.329AC(18:2) 0.070 0.005 0.135 0.036 0.239 0.048 -0.010 0.107 0.106 0.330 -0.043 -0.087 0.001 0.055 0.264 -0.043 -0.104 0.018 0.166 0.371LPC(22:1) [sn2] 0.075 0.005 0.145 0.037 0.241 -0.042 -0.105 0.021 0.187 0.426 0.003 -0.044 0.050 0.908 0.962 -0.046 -0.111 0.019 0.169 0.372PE(P-17:0/22:6) (b) -0.074 -0.145 -0.004 0.039 0.250 -0.102 -0.164 -0.040 0.001 0.036 0.081 0.035 0.127 0.001 0.013 0.049 -0.015 0.113 0.133 0.334HexCer(d18:1/24:0) 0.081 0.004 0.159 0.039 0.251 -0.028 -0.095 0.039 0.411 0.617 0.003 -0.047 0.053 0.915 0.964 0.019 -0.051 0.088 0.600 0.785dhCer(d18:0/22:0) -0.082 -0.161 -0.003 0.042 0.251 -0.022 -0.091 0.047 0.527 0.718 0.048 -0.004 0.099 0.072 0.302 0.033 -0.039 0.106 0.368 0.597SM(d18:1/18:0) & SM(d16:1/20:0) -0.085 -0.166 -0.004 0.040 0.251 -0.012 -0.084 0.059 0.740 0.871 0.015 -0.041 0.070 0.603 0.815 -0.044 -0.119 0.032 0.261 0.471PC(18:1_18:2) 0.084 0.003 0.165 0.043 0.251 0.040 -0.033 0.113 0.280 0.515 0.028 -0.029 0.084 0.340 0.648 -0.008 -0.083 0.067 0.832 0.911PE(P-16:0/22:6) -0.076 -0.149 -0.003 0.042 0.251 -0.125 -0.190 -0.061 0.000 0.016 0.089 0.041 0.136 0.000 0.008 0.034 -0.033 0.100 0.325 0.551PE(P-15:0/22:6) (a) -0.068 -0.133 -0.003 0.040 0.251 -0.064 -0.122 -0.006 0.031 0.188 0.051 0.008 0.095 0.021 0.158 0.075 0.014 0.135 0.015 0.110LPE(22:6) [sn1] 0.075 0.003 0.148 0.042 0.251 -0.040 -0.105 0.025 0.225 0.469 -0.004 -0.053 0.044 0.859 0.945 0.004 -0.063 0.071 0.898 0.948PE(P-16:0/20:4) -0.070 -0.138 -0.002 0.043 0.251 -0.051 -0.111 0.009 0.094 0.310 0.073 0.028 0.118 0.002 0.027 0.010 -0.052 0.073 0.742 0.863deDE(18:2) 0.078 0.002 0.154 0.043 0.251 0.053 -0.013 0.119 0.115 0.344 -0.141 -0.189 -0.093 0.000 0.000 -0.115 -0.183 -0.046 0.001 0.028TG(58:8) [NL-22:6] -0.069 -0.136 -0.003 0.041 0.251 -0.093 -0.153 -0.034 0.002 0.044 0.059 0.015 0.104 0.009 0.100 0.021 -0.041 0.083 0.499 0.701TG(48:3) [NL-14:0] 0.102 0.004 0.199 0.042 0.251 0.129 0.038 0.220 0.005 0.077 -0.109 -0.177 -0.040 0.002 0.034 -0.162 -0.255 -0.069 0.001 0.027TG(56:8) [NL-22:6] -0.075 -0.147 -0.003 0.042 0.251 -0.086 -0.150 -0.022 0.008 0.096 0.040 -0.008 0.088 0.099 0.359 0.018 -0.049 0.084 0.607 0.789TG(50:0) [NL-18:0] -0.086 -0.169 -0.003 0.043 0.251 -0.028 -0.104 0.048 0.469 0.664 -0.018 -0.076 0.039 0.528 0.773 -0.023 -0.103 0.057 0.575 0.75895% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper) ### Page 14 LPC(P-20:0) 0.070 0.002 0.139 0.044 0.254 0.033 -0.029 0.095 0.294 0.528 -0.023 -0.071 0.026 0.362 0.669 -0.083 -0.147 -0.019 0.011 0.090LPC(22:0) [sn2] 0.072 0.002 0.143 0.045 0.255 -0.003 -0.067 0.060 0.914 0.964 0.026 -0.021 0.073 0.276 0.596 0.042 -0.023 0.107 0.201 0.407SM(43:1) -0.075 -0.149 -0.001 0.046 0.257 -0.025 -0.091 0.041 0.457 0.656 0.102 0.052 0.151 0.000 0.002 0.061 -0.009 0.130 0.087 0.273LPC(16:0) [sn1] 0.074 0.001 0.146 0.046 0.257 0.034 -0.030 0.099 0.296 0.528 -0.019 -0.075 0.037 0.504 0.757 -0.066 -0.133 0.001 0.055 0.213PE(O-38:5) (a) -0.070 -0.140 -0.001 0.046 0.257 -0.014 -0.076 0.048 0.658 0.815 0.045 -0.002 0.092 0.062 0.284 0.006 -0.058 0.071 0.849 0.916PE(P-18:0/18:1) -0.072 -0.143 -0.001 0.046 0.258 -0.062 -0.125 0.001 0.055 0.253 0.095 0.048 0.143 0.000 0.003 0.059 -0.006 0.124 0.075 0.259SM(d18:1/22:0) & SM(d16:1/24:0) -0.091 -0.180 -0.001 0.047 0.259 -0.019 -0.098 0.060 0.641 0.799 0.095 0.034 0.156 0.002 0.038 0.035 -0.050 0.119 0.422 0.642HexCer(d16:1/22:0) 0.070 0.001 0.139 0.048 0.260 0.068 0.007 0.128 0.029 0.182 -0.017 -0.062 0.029 0.471 0.737 -0.004 -0.068 0.059 0.891 0.944LPC(15-MHDA) [sn1] & LPC(17:0) [sn2] 0.068 0.000 0.136 0.049 0.260 0.034 -0.027 0.094 0.274 0.509 -0.004 -0.052 0.045 0.879 0.953 -0.052 -0.115 0.011 0.103 0.287LPC(O-22:0) 0.071 0.000 0.142 0.049 0.260 0.026 -0.037 0.090 0.416 0.620 -0.007 -0.056 0.042 0.783 0.910 -0.079 -0.144 -0.013 0.019 0.125LPC(20:3) [sn1] 0.071 0.000 0.142 0.049 0.260 0.078 0.016 0.140 0.014 0.116 0.024 -0.025 0.073 0.343 0.650 -0.008 -0.073 0.057 0.806 0.899TG(52:4) [NL-16:1] 0.073 0.000 0.145 0.049 0.260 0.070 0.003 0.137 0.041 0.215 -0.045 -0.103 0.012 0.122 0.393 -0.083 -0.152 -0.013 0.020 0.128TG(O-52:1) [NL-18:1] -0.071 -0.142 0.000 0.050 0.262 -0.043 -0.107 0.022 0.194 0.429 0.106 0.057 0.155 0.000 0.001 0.004 -0.062 0.071 0.901 0.948Cer(d18:2/21:0) 0.074 0.000 0.148 0.051 0.264 0.080 0.015 0.144 0.016 0.131 -0.034 -0.083 0.014 0.167 0.458 -0.094 -0.161 -0.028 0.005 0.065PC(O-18:1/18:1) 0.089 0.000 0.178 0.051 0.264 0.034 -0.045 0.113 0.394 0.602 0.050 -0.012 0.111 0.111 0.381 -0.033 -0.114 0.048 0.427 0.644SHexCer(d18:1/24:0(OH)) 0.073 -0.001 0.147 0.053 0.264 -0.015 -0.081 0.051 0.655 0.812 0.009 -0.040 0.057 0.721 0.887 -0.011 -0.079 0.057 0.751 0.870PC(O-34:4) -0.068 -0.137 0.001 0.053 0.264 -0.021 -0.083 0.040 0.500 0.693 0.021 -0.025 0.067 0.367 0.672 -0.034 -0.098 0.029 0.291 0.510LPC(22:0) [sn1] 0.071 -0.001 0.142 0.052 0.264 0.000 -0.064 0.063 0.992 0.994 0.021 -0.027 0.069 0.385 0.678 0.024 -0.041 0.089 0.471 0.685PE(P-18:0/20:3) (b) -0.070 -0.140 0.001 0.052 0.264 -0.010 -0.072 0.051 0.741 0.871 0.047 0.000 0.095 0.051 0.256 -0.016 -0.080 0.049 0.629 0.806TG(54:7) [NL-22:6] -0.077 -0.154 0.000 0.051 0.264 -0.070 -0.138 -0.001 0.047 0.225 0.016 -0.035 0.067 0.541 0.779 -0.017 -0.089 0.054 0.632 0.806TG(48:3) [NL-16:1] 0.096 -0.001 0.193 0.052 0.264 0.153 0.066 0.240 0.001 0.026 -0.127 -0.195 -0.059 0.000 0.008 -0.185 -0.275 -0.095 0.000 0.011Hex2Cer(d18:1/22:0) 0.077 -0.001 0.155 0.054 0.266 0.072 0.003 0.142 0.042 0.215 -0.011 -0.062 0.041 0.687 0.868 -0.048 -0.120 0.025 0.198 0.403LPC(26:0) [sn1] 0.083 -0.001 0.168 0.054 0.266 0.002 -0.073 0.076 0.961 0.980 -0.003 -0.057 0.051 0.913 0.964 -0.024 -0.100 0.051 0.526 0.725Hex2Cer(d16:1/16:0) 0.066 -0.002 0.133 0.055 0.271 0.051 -0.009 0.111 0.093 0.310 -0.038 -0.082 0.006 0.093 0.346 -0.044 -0.106 0.018 0.166 0.371PI(18:0_22:5) (n6) -0.066 -0.134 0.002 0.056 0.272 0.015 -0.045 0.076 0.619 0.783 0.024 -0.020 0.069 0.285 0.602 -0.033 -0.096 0.029 0.299 0.519AC(20:3) (a) 0.064 -0.002 0.129 0.056 0.272 0.044 -0.014 0.103 0.138 0.372 -0.005 -0.048 0.038 0.820 0.925 -0.006 -0.067 0.054 0.833 0.911HexCer(d18:1/16:0) 0.067 -0.002 0.136 0.057 0.274 -0.006 -0.067 0.055 0.849 0.938 -0.009 -0.055 0.037 0.689 0.868 -0.031 -0.095 0.033 0.348 0.574TG(O-52:1) [NL-16:0] -0.071 -0.144 0.002 0.057 0.274 -0.032 -0.097 0.034 0.347 0.575 0.084 0.032 0.136 0.001 0.027 -0.010 -0.079 0.059 0.784 0.884DG(18:0_18:1) -0.114 -0.233 0.004 0.059 0.278 -0.103 -0.203 -0.003 0.044 0.218 0.000 -0.078 0.079 0.990 0.994 -0.075 -0.181 0.031 0.164 0.371LPI(18:1) [sn1] -0.064 -0.131 0.003 0.060 0.282 -0.002 -0.060 0.057 0.956 0.980 0.034 -0.011 0.080 0.135 0.417 -0.008 -0.070 0.053 0.794 0.891PE(P-17:0/20:4) (b) -0.064 -0.131 0.003 0.060 0.282 -0.036 -0.095 0.023 0.235 0.480 0.062 0.017 0.107 0.006 0.078 -0.001 -0.063 0.060 0.963 0.977LPE(18:0) [sn1] 0.075 -0.003 0.153 0.061 0.282 0.018 -0.051 0.088 0.607 0.778 -0.041 -0.096 0.014 0.141 0.424 -0.080 -0.153 -0.008 0.030 0.159Hex2Cer(d18:2/16:0) 0.067 -0.005 0.139 0.067 0.311 0.029 -0.034 0.093 0.363 0.580 -0.026 -0.073 0.021 0.282 0.601 -0.051 -0.117 0.015 0.132 0.333PE(O-36:5) -0.065 -0.135 0.005 0.068 0.311 -0.078 -0.141 -0.015 0.015 0.121 0.021 -0.026 0.067 0.386 0.678 0.036 -0.029 0.100 0.278 0.489PC(O-34:1) 0.081 -0.007 0.169 0.070 0.317 0.043 -0.036 0.122 0.283 0.518 0.026 -0.036 0.089 0.405 0.695 -0.045 -0.127 0.036 0.274 0.483PE(O-16:0/20:4) -0.064 -0.133 0.005 0.070 0.317 -0.033 -0.094 0.028 0.290 0.525 0.044 -0.002 0.091 0.058 0.270 -0.019 -0.083 0.044 0.549 0.739TG(50:2) [NL-14:0] 0.069 -0.006 0.144 0.070 0.317 0.048 -0.023 0.120 0.185 0.426 -0.029 -0.084 0.025 0.294 0.616 -0.035 -0.109 0.038 0.346 0.572TG(50:4) [NL-18:3] 0.090 -0.008 0.187 0.071 0.317 0.122 0.033 0.212 0.007 0.093 -0.083 -0.152 -0.014 0.019 0.151 -0.147 -0.240 -0.054 0.002 0.041HexCer(d18:1/22:0) 0.069 -0.006 0.145 0.073 0.322 0.017 -0.049 0.084 0.605 0.778 0.018 -0.032 0.068 0.476 0.737 -0.016 -0.085 0.054 0.655 0.816PE(P-16:0/20:5) -0.064 -0.135 0.006 0.072 0.322 -0.091 -0.155 -0.028 0.005 0.073 0.042 -0.005 0.089 0.080 0.322 0.056 -0.009 0.120 0.093 0.278TG(O-52:2) [NL-17:1] -0.065 -0.137 0.006 0.074 0.326 -0.068 -0.132 -0.003 0.040 0.210 0.138 0.089 0.187 0.000 0.000 0.068 0.000 0.135 0.050 0.204LPE(18:0) [sn2] 0.070 -0.007 0.148 0.076 0.327 0.009 -0.060 0.078 0.793 0.907 -0.034 -0.088 0.020 0.214 0.524 -0.063 -0.135 0.010 0.089 0.275PE(P-16:0/20:3) (b) -0.063 -0.133 0.006 0.075 0.327 -0.003 -0.065 0.059 0.923 0.964 0.057 0.011 0.104 0.016 0.137 -0.005 -0.068 0.059 0.883 0.937AC(15:0) (a) -0.060 -0.127 0.006 0.076 0.327 -0.029 -0.089 0.031 0.343 0.572 0.008 -0.036 0.051 0.730 0.887 -0.020 -0.081 0.041 0.525 0.725TG(54:5) [NL-18:3] 0.066 -0.007 0.138 0.076 0.327 0.046 -0.022 0.114 0.181 0.425 0.002 -0.053 0.057 0.943 0.973 -0.031 -0.102 0.039 0.383 0.610PC(18:1_22:6) (a) 0.063 -0.007 0.133 0.077 0.329 -0.023 -0.086 0.039 0.464 0.661 0.029 -0.019 0.077 0.233 0.546 0.008 -0.057 0.073 0.805 0.899GM3(d18:1/18:0) -0.068 -0.144 0.008 0.080 0.331 -0.029 -0.096 0.038 0.392 0.600 0.002 -0.050 0.054 0.930 0.969 -0.042 -0.113 0.029 0.246 0.457PE(P-18:0/22:5) (n6) -0.062 -0.131 0.007 0.079 0.331 0.032 -0.030 0.094 0.306 0.541 0.025 -0.022 0.072 0.297 0.616 -0.039 -0.103 0.025 0.233 0.444AC(13:0) -0.061 -0.128 0.007 0.080 0.331 -0.069 -0.129 -0.009 0.025 0.169 0.040 -0.004 0.085 0.077 0.317 0.006 -0.056 0.068 0.853 0.918TG(54:2) [NL-20:1] -0.089 -0.187 0.010 0.079 0.331 -0.008 -0.096 0.080 0.853 0.939 0.055 -0.013 0.123 0.111 0.381 -0.018 -0.111 0.074 0.699 0.840DG(18:1_18:3) 0.090 -0.010 0.191 0.078 0.331 0.017 -0.072 0.106 0.709 0.853 -0.027 -0.095 0.040 0.426 0.713 -0.085 -0.177 0.007 0.070 0.250PE(P-18:1/20:5) (a) -0.063 -0.135 0.008 0.082 0.335 -0.108 -0.173 -0.043 0.001 0.034 0.052 0.004 0.100 0.034 0.209 0.078 0.011 0.144 0.022 0.134TG(O-54:3) [NL-17:1] -0.061 -0.130 0.008 0.081 0.335 -0.044 -0.106 0.017 0.156 0.392 0.114 0.066 0.162 0.000 0.000 0.010 -0.055 0.074 0.771 0.875CE(24:1) 0.075 -0.010 0.160 0.082 0.337 -0.006 -0.079 0.067 0.875 0.946 -0.009 -0.063 0.045 0.742 0.892 -0.107 -0.184 -0.030 0.007 0.073S1P(d18:1) 0.057 -0.008 0.122 0.086 0.338 0.055 -0.003 0.113 0.064 0.268 -0.025 -0.071 0.021 0.292 0.612 -0.043 -0.103 0.018 0.167 0.372HexCer(d16:1/24:0) 0.062 -0.009 0.133 0.086 0.338 0.019 -0.042 0.080 0.538 0.729 -0.031 -0.077 0.016 0.195 0.497 0.015 -0.048 0.079 0.640 0.810HexCer(d18:1/20:0) 0.063 -0.009 0.135 0.085 0.338 0.013 -0.051 0.078 0.681 0.831 -0.013 -0.060 0.035 0.599 0.814 -0.041 -0.108 0.026 0.234 0.444PC(16:0_18:2) 0.068 -0.009 0.145 0.085 0.338 0.060 -0.010 0.130 0.091 0.310 -0.027 -0.079 0.026 0.322 0.635 0.004 -0.068 0.077 0.907 0.948PC(O-34:2) 0.066 -0.009 0.142 0.085 0.338 0.039 -0.028 0.105 0.253 0.492 0.018 -0.032 0.068 0.476 0.737 -0.017 -0.087 0.052 0.622 0.800PC(P-16:0/18:3) 0.067 -0.009 0.143 0.085 0.338 0.033 -0.034 0.099 0.336 0.569 0.050 0.000 0.100 0.051 0.256 0.024 -0.045 0.094 0.494 0.696TG(O-50:3) [NL-18:2] 0.060 -0.008 0.128 0.084 0.338 -0.028 -0.088 0.032 0.359 0.579 0.014 -0.031 0.058 0.554 0.783 -0.019 -0.081 0.043 0.538 0.729PC(18:0_20:3) -0.073 -0.157 0.011 0.088 0.345 0.025 -0.049 0.100 0.502 0.695 0.054 -0.004 0.111 0.067 0.294 0.045 -0.033 0.123 0.256 0.465LPC(22:4) [sn1] 0.060 -0.009 0.129 0.089 0.345 0.117 0.056 0.179 0.000 0.016 -0.054 -0.103 -0.005 0.031 0.197 -0.085 -0.150 -0.020 0.010 0.089TG(52:5) [NL-18:3] 0.078 -0.012 0.168 0.089 0.345 0.086 0.003 0.168 0.042 0.215 -0.046 -0.110 0.018 0.156 0.446 -0.093 -0.179 -0.008 0.033 0.168PI(18:1_18:2) 0.061 -0.010 0.132 0.091 0.350 0.050 -0.014 0.114 0.126 0.357 0.028 -0.020 0.076 0.260 0.577 -0.012 -0.077 0.054 0.730 0.856LPC(19:0) [sn2] (a) 0.060 -0.010 0.130 0.093 0.356 0.003 -0.059 0.066 0.915 0.964 0.028 -0.018 0.075 0.231 0.544 0.003 -0.061 0.068 0.917 0.955methyl-DE(18:1) -0.062 -0.134 0.010 0.093 0.356 -0.031 -0.096 0.035 0.357 0.578 0.069 0.021 0.117 0.005 0.057 0.096 0.029 0.162 0.005 0.061PE(18:0_18:1) -0.069 -0.149 0.012 0.095 0.357 -0.043 -0.117 0.032 0.262 0.493 0.022 -0.034 0.078 0.439 0.718 0.035 -0.042 0.112 0.376 0.604PE(P-18:1/20:5) (b) -0.061 -0.132 0.010 0.094 0.357 -0.022 -0.085 0.042 0.504 0.697 0.031 -0.017 0.079 0.202 0.507 0.004 -0.061 0.068 0.915 0.955DE(16:0) -0.055 -0.119 0.009 0.094 0.357 -0.021 -0.078 0.037 0.481 0.674 -0.024 -0.066 0.018 0.269 0.588 -0.002 -0.061 0.057 0.949 0.973AC(14:0)-OH -0.055 -0.120 0.010 0.097 0.363 -0.008 -0.066 0.050 0.787 0.902 -0.010 -0.054 0.033 0.641 0.837 -0.043 -0.104 0.017 0.160 0.364AC(14:1)-OH -0.055 -0.120 0.010 0.098 0.367 -0.005 -0.063 0.054 0.879 0.947 0.001 -0.042 0.045 0.957 0.981 -0.024 -0.085 0.037 0.441 0.657Hex2Cer(d18:1/24:0) 0.065 -0.012 0.142 0.100 0.368 0.046 -0.022 0.114 0.188 0.426 -0.033 -0.083 0.017 0.197 0.501 -0.018 -0.088 0.053 0.627 0.805LPE(18:1) [sn2] 0.058 -0.011 0.127 0.099 0.368 0.045 -0.016 0.107 0.150 0.384 -0.001 -0.048 0.046 0.977 0.990 -0.010 -0.075 0.055 0.765 0.874LPE(18:1) [sn1] 0.058 -0.011 0.126 0.101 0.370 0.045 -0.017 0.107 0.152 0.385 -0.001 -0.049 0.047 0.972 0.988 -0.031 -0.095 0.034 0.351 0.576Cer(d18:2/24:0) 0.063 -0.012 0.137 0.102 0.372 0.009 -0.058 0.076 0.793 0.907 -0.001 -0.050 0.049 0.982 0.992 0.010 -0.059 0.078 0.787 0.886GM3(d18:1/16:0) 0.069 -0.014 0.152 0.102 0.372 0.033 -0.041 0.107 0.381 0.591 -0.031 -0.089 0.028 0.302 0.620 -0.164 -0.240 -0.087 0.000 0.011PI(18:0_22:5) (n3) -0.064 -0.141 0.013 0.104 0.372 -0.002 -0.070 0.067 0.959 0.980 -0.046 -0.099 0.006 0.081 0.324 -0.051 -0.123 0.020 0.159 0.363DG(18:2_18:2) 0.067 -0.014 0.147 0.104 0.372 0.009 -0.065 0.082 0.816 0.920 -0.036 -0.093 0.020 0.209 0.517 -0.050 -0.125 0.026 0.199 0.404TG(51:0) [NL-16:0] -0.069 -0.153 0.014 0.104 0.372 0.008 -0.068 0.084 0.833 0.930 -0.022 -0.080 0.035 0.445 0.723 -0.029 -0.108 0.051 0.480 0.689DG(18:2_22:6) -0.059 -0.130 0.012 0.104 0.372 -0.093 -0.156 -0.031 0.004 0.060 0.046 -0.001 0.093 0.057 0.270 0.005 -0.060 0.071 0.874 0.931PC(P-16:0/20:4) -0.066 -0.145 0.014 0.108 0.383 0.007 -0.062 0.076 0.842 0.937 0.059 0.006 0.111 0.028 0.185 -0.046 -0.118 0.025 0.205 0.412Cer(d17:1/18:0) -0.055 -0.123 0.013 0.111 0.392 -0.019 -0.080 0.042 0.544 0.732 0.011 -0.035 0.056 0.638 0.835 -0.002 -0.065 0.062 0.958 0.977SM(d18:2/18:0) -0.064 -0.144 0.015 0.111 0.392 0.002 -0.067 0.071 0.953 0.980 0.004 -0.053 0.062 0.881 0.953 -0.082 -0.154 -0.010 0.026 0.152PC(O-38:5) 0.056 -0.013 0.125 0.113 0.395 0.048 -0.014 0.111 0.127 0.357 0.046 -0.003 0.094 0.067 0.294 -0.076 -0.141 -0.012 0.020 0.128PI(34:1) -0.062 -0.139 0.015 0.113 0.395 0.018 -0.052 0.087 0.618 0.783 0.017 -0.035 0.069 0.527 0.773 -0.032 -0.104 0.040 0.387 0.611PC(33:0) (b) 0.058 -0.015 0.132 0.116 0.403 0.044 -0.022 0.110 0.189 0.426 -0.007 -0.057 0.044 0.790 0.912 -0.058 -0.126 0.010 0.094 0.278dimethyl-CE(18:2) -0.057 -0.128 0.015 0.119 0.412 -0.042 -0.106 0.023 0.204 0.446 0.070 0.022 0.117 0.004 0.057 0.099 0.033 0.165 0.003 0.049DG(18:0_20:4) -0.069 -0.156 0.018 0.122 0.420 -0.054 -0.130 0.021 0.157 0.393 -0.019 -0.078 0.040 0.529 0.773 -0.067 -0.147 0.012 0.098 0.282LPC(17:1) [sn1] (b) 0.053 -0.015 0.121 0.124 0.425 0.047 -0.013 0.107 0.123 0.351 -0.019 -0.064 0.025 0.393 0.685 -0.035 -0.097 0.027 0.272 0.482Hex2Cer(d18:1/20:0) 0.058 -0.016 0.132 0.127 0.432 0.070 0.006 0.135 0.033 0.190 -0.036 -0.083 0.012 0.144 0.427 -0.031 -0.099 0.037 0.368 0.597SHexCer(d18:1/24:1(OH)) 0.055 -0.016 0.125 0.128 0.433 -0.021 -0.084 0.042 0.509 0.702 -0.002 -0.050 0.047 0.943 0.973 -0.059 -0.124 0.006 0.075 0.259dhCer(d18:0/16:0) -0.060 -0.137 0.018 0.130 0.437 -0.004 -0.071 0.063 0.905 0.960 0.035 -0.014 0.084 0.162 0.454 0.013 -0.055 0.082 0.705 0.840GM3(d18:1/24:0) 0.063 -0.019 0.144 0.131 0.438 0.062 -0.011 0.135 0.097 0.312 -0.011 -0.065 0.042 0.678 0.860 0.000 -0.075 0.075 0.996 0.997Cer(m18:1/23:0) -0.063 -0.144 0.019 0.132 0.441 -0.030 -0.101 0.041 0.404 0.610 0.009 -0.044 0.062 0.743 0.892 0.007 -0.066 0.081 0.851 0.917PC(16:0_18:3) (a) 0.068 -0.021 0.156 0.132 0.441 0.102 0.026 0.179 0.009 0.099 -0.049 -0.109 0.012 0.114 0.387 -0.100 -0.181 -0.020 0.015 0.108PC(16:1_20:4) 0.068 -0.021 0.158 0.133 0.442 0.122 0.047 0.198 0.002 0.037 -0.074 -0.132 -0.016 0.013 0.118 -0.150 -0.230 -0.071 0.000 0.017PC(38:5) (b) -0.059 -0.136 0.018 0.134 0.442 0.004 -0.063 0.071 0.909 0.961 -0.036 -0.087 0.016 0.179 0.479 -0.057 -0.126 0.013 0.111 0.301PE(P-17:0/22:6) (a) -0.054 -0.124 0.017 0.134 0.442 -0.077 -0.140 -0.015 0.015 0.124 0.069 0.023 0.116 0.003 0.050 0.018 -0.046 0.083 0.574 0.758Cer(d16:1/22:0) 0.057 -0.018 0.132 0.138 0.448 0.060 -0.007 0.126 0.078 0.289 -0.003 -0.052 0.046 0.908 0.962 0.010 -0.059 0.079 0.776 0.878PE(P-15:0/20:4) (a) -0.050 -0.115 0.016 0.137 0.448 0.007 -0.051 0.065 0.812 0.918 0.040 -0.003 0.083 0.071 0.302 0.012 -0.048 0.072 0.700 0.840PC(16:0_18:0) 0.071 -0.023 0.164 0.139 0.452 0.037 -0.046 0.119 0.382 0.592 -0.007 -0.075 0.060 0.833 0.929 -0.131 -0.216 -0.046 0.003 0.044PC(O-16:0/22:6) -0.054 -0.127 0.018 0.141 0.455 -0.102 -0.166 -0.038 0.002 0.041 0.064 0.016 0.112 0.009 0.100 -0.012 -0.078 0.053 0.711 0.841SM(d18:2/23:0) -0.071 -0.167 0.025 0.146 0.463 0.002 -0.081 0.084 0.969 0.982 0.056 -0.007 0.119 0.079 0.320 0.054 -0.034 0.141 0.230 0.442PC(18:0_18:1) -0.063 -0.147 0.022 0.147 0.463 -0.007 -0.083 0.069 0.855 0.939 -0.004 -0.063 0.055 0.892 0.957 -0.024 -0.103 0.055 0.558 0.748PC(P-16:0/22:6) -0.058 -0.137 0.020 0.147 0.463 -0.127 -0.196 -0.059 0.000 0.019 0.084 0.033 0.136 0.001 0.026 0.040 -0.030 0.111 0.263 0.473LPC(14:0) [sn2] 0.053 -0.018 0.124 0.146 0.463 0.048 -0.015 0.112 0.137 0.371 -0.056 -0.104 -0.008 0.022 0.160 -0.078 -0.144 -0.012 0.020 0.128dimethyl-CE(18:1) -0.054 -0.126 0.019 0.146 0.463 -0.057 -0.123 0.008 0.086 0.306 0.076 0.027 0.125 0.002 0.038 0.069 0.002 0.137 0.044 0.193TG(52:4) [NL-18:3] 0.066 -0.023 0.154 0.145 0.463 0.115 0.032 0.197 0.006 0.084 -0.045 -0.112 0.021 0.184 0.482 -0.081 -0.168 0.005 0.066 0.245HexCer(d16:1/20:0) 0.050 -0.018 0.118 0.149 0.464 0.022 -0.038 0.082 0.475 0.669 -0.024 -0.069 0.020 0.285 0.602 0.006 -0.057 0.069 0.848 0.916PC(P-18:1/18:1) 0.071 -0.026 0.168 0.149 0.464 0.051 -0.031 0.134 0.221 0.465 0.016 -0.048 0.081 0.620 0.825 -0.072 -0.158 0.013 0.095 0.278PC(O-16:0/16:0) 0.059 -0.022 0.141 0.152 0.468 0.062 -0.010 0.135 0.092 0.310 -0.029 -0.085 0.027 0.312 0.628 -0.081 -0.157 -0.005 0.037 0.182PE(18:0_22:5) (n6) -0.063 -0.150 0.023 0.151 0.468 0.058 -0.020 0.135 0.144 0.379 -0.015 -0.075 0.044 0.611 0.820 -0.073 -0.154 0.009 0.079 0.268PE(P-17:0/20:4) (a) -0.049 -0.116 0.018 0.152 0.468 -0.001 -0.060 0.058 0.973 0.982 0.052 0.008 0.097 0.021 0.158 -0.012 -0.074 0.050 0.702 0.840TG(58:9) [NL-22:6] -0.049 -0.117 0.018 0.153 0.468 -0.079 -0.139 -0.018 0.011 0.104 0.053 0.007 0.098 0.023 0.166 0.020 -0.042 0.083 0.523 0.724TG(53:2) [NL-17:1] -0.070 -0.164 0.025 0.151 0.468 0.022 -0.062 0.106 0.605 0.778 0.005 -0.061 0.070 0.889 0.955 -0.113 -0.203 -0.024 0.013 0.099LPC(24:0) [sn1] 0.055 -0.021 0.131 0.155 0.470 -0.016 -0.083 0.051 0.642 0.799 0.024 -0.026 0.074 0.343 0.650 0.039 -0.029 0.108 0.260 0.471TG(54:2) [NL-18:0] -0.072 -0.171 0.027 0.156 0.470 -0.028 -0.114 0.058 0.522 0.715 0.025 -0.041 0.092 0.455 0.730 -0.042 -0.133 0.050 0.375 0.604DG(18:1_22:5) -0.067 -0.160 0.026 0.156 0.470 -0.050 -0.131 0.032 0.231 0.475 -0.008 -0.069 0.053 0.799 0.916 -0.071 -0.155 0.014 0.100 0.284HexCer(d18:2/20:0) 0.054 -0.021 0.129 0.157 0.471 0.021 -0.044 0.086 0.520 0.714 0.028 -0.020 0.076 0.253 0.572 0.024 -0.044 0.093 0.491 0.696PE(P-18:0/22:5) (n3) -0.051 -0.123 0.020 0.157 0.471 0.003 -0.061 0.066 0.937 0.971 0.007 -0.040 0.054 0.778 0.907 0.015 -0.050 0.081 0.644 0.812TG(52:5) [NL-20:5] -0.053 -0.127 0.021 0.158 0.471 -0.032 -0.099 0.035 0.354 0.576 -0.008 -0.058 0.043 0.761 0.900 0.003 -0.067 0.074 0.927 0.961LPC(22:6) [sn1] 0.050 -0.020 0.119 0.160 0.471 -0.047 -0.108 0.014 0.132 0.362 0.036 -0.011 0.083 0.138 0.421 -0.024 -0.087 0.039 0.457 0.671LPC(20:4) [sn1] 0.050 -0.020 0.120 0.159 0.471 0.055 -0.006 0.117 0.079 0.292 -0.013 -0.061 0.035 0.594 0.811 -0.079 -0.144 -0.015 0.016 0.115DE(18:2) -0.068 -0.162 0.027 0.160 0.471 0.001 -0.083 0.085 0.976 0.983 0.008 -0.053 0.068 0.805 0.919 0.063 -0.023 0.150 0.153 0.358TG(O-52:2) [NL-18:1] -0.050 -0.119 0.020 0.160 0.471 -0.067 -0.129 -0.005 0.034 0.194 0.138 0.090 0.185 0.000 0.000 0.045 -0.020 0.110 0.172 0.378LPC(22:5) [sn1] (n6) 0.049 -0.020 0.119 0.162 0.475 0.106 0.044 0.167 0.001 0.030 -0.012 -0.060 0.037 0.629 0.829 -0.060 -0.125 0.004 0.068 0.248dhCer(d18:0/18:0) -0.050 -0.121 0.021 0.165 0.480 -0.033 -0.094 0.029 0.299 0.530 -0.017 -0.063 0.029 0.477 0.737 -0.038 -0.102 0.026 0.244 0.455PI(34:0) -0.055 -0.132 0.023 0.165 0.480 -0.043 -0.111 0.024 0.207 0.451 -0.011 -0.061 0.039 0.677 0.860 -0.029 -0.098 0.041 0.419 0.640PE(O-34:1) -0.052 -0.127 0.022 0.169 0.490 -0.051 -0.118 0.016 0.138 0.372 0.099 0.049 0.148 0.000 0.004 0.045 -0.023 0.114 0.194 0.398SM(44:2) -0.056 -0.137 0.024 0.171 0.490 -0.079 -0.150 -0.008 0.029 0.183 0.057 0.004 0.110 0.036 0.211 0.019 -0.056 0.094 0.616 0.798LPC(20:4) [+OH] 0.045 -0.019 0.109 0.171 0.490 0.041 -0.017 0.098 0.163 0.398 -0.016 -0.058 0.027 0.478 0.737 -0.009 -0.068 0.050 0.766 0.874Cer(d18:2/23:0) 0.054 -0.024 0.133 0.172 0.491 0.051 -0.018 0.121 0.148 0.381 -0.021 -0.073 0.032 0.438 0.718 -0.016 -0.088 0.055 0.655 0.816 ### Page 15 AC(26:0) -0.050 -0.121 0.022 0.172 0.491 -0.033 -0.097 0.031 0.308 0.541 0.055 0.008 0.102 0.021 0.158 0.065 -0.001 0.131 0.054 0.212DG(18:1_18:2) 0.072 -0.032 0.176 0.173 0.492 -0.025 -0.117 0.066 0.588 0.770 -0.029 -0.101 0.042 0.423 0.711 -0.073 -0.167 0.022 0.132 0.333PE(38:5) (b) -0.061 -0.149 0.027 0.177 0.495 0.006 -0.073 0.084 0.889 0.954 -0.073 -0.133 -0.013 0.017 0.142 -0.082 -0.163 -0.001 0.047 0.200PE(O-16:0/20:3) -0.048 -0.118 0.022 0.177 0.495 -0.001 -0.064 0.061 0.973 0.982 0.017 -0.032 0.066 0.505 0.757 -0.031 -0.096 0.033 0.342 0.569AC(24:1)-OH -0.047 -0.114 0.021 0.177 0.495 -0.033 -0.094 0.027 0.275 0.510 0.012 -0.033 0.058 0.590 0.811 -0.012 -0.074 0.050 0.700 0.840TG(58:10) [NL-22:6] -0.047 -0.115 0.021 0.176 0.495 -0.065 -0.126 -0.004 0.036 0.197 0.037 -0.009 0.082 0.116 0.388 0.001 -0.063 0.065 0.978 0.986SM(d16:1/23:0) & SM(d17:1/22:0) -0.056 -0.139 0.026 0.181 0.495 0.032 -0.040 0.105 0.384 0.592 0.059 0.004 0.114 0.036 0.211 0.053 -0.024 0.131 0.177 0.382GM3(d18:1/22:0) 0.053 -0.024 0.130 0.179 0.495 0.070 0.001 0.140 0.046 0.224 -0.031 -0.087 0.026 0.286 0.604 -0.142 -0.215 -0.070 0.000 0.012PS(38:3) 0.044 -0.020 0.107 0.181 0.495 0.022 -0.035 0.079 0.453 0.653 0.007 -0.037 0.050 0.768 0.902 0.067 0.008 0.126 0.026 0.152AC(18:0)-OH -0.045 -0.111 0.021 0.179 0.495 0.024 -0.035 0.084 0.426 0.628 -0.017 -0.062 0.029 0.474 0.737 -0.097 -0.158 -0.036 0.002 0.041AC(22:5)-OH -0.047 -0.115 0.022 0.180 0.495 -0.070 -0.130 -0.009 0.025 0.169 0.048 0.003 0.093 0.039 0.220 0.040 -0.023 0.104 0.210 0.419TG(50:3) [NL-16:1] 0.058 -0.027 0.144 0.180 0.495 0.132 0.054 0.210 0.001 0.033 -0.107 -0.168 -0.045 0.001 0.016 -0.145 -0.227 -0.062 0.001 0.025LPC(20:3) [sn2] 0.050 -0.024 0.123 0.183 0.497 0.068 0.005 0.132 0.036 0.196 0.028 -0.020 0.077 0.252 0.572 0.016 -0.051 0.083 0.635 0.808deDE(20:4) 0.047 -0.022 0.116 0.183 0.497 0.060 -0.002 0.122 0.057 0.254 -0.110 -0.155 -0.065 0.000 0.000 -0.116 -0.179 -0.053 0.000 0.017Cer(d17:1/24:0) 0.050 -0.024 0.124 0.185 0.501 0.037 -0.029 0.102 0.269 0.506 0.020 -0.028 0.069 0.416 0.705 0.024 -0.044 0.092 0.488 0.696LPC(18:0) [sn1] 0.049 -0.024 0.122 0.187 0.503 0.014 -0.050 0.079 0.662 0.818 -0.006 -0.058 0.047 0.832 0.929 -0.054 -0.121 0.013 0.117 0.310PI(16:0/16:0) -0.051 -0.126 0.025 0.188 0.504 0.012 -0.056 0.079 0.734 0.868 -0.023 -0.074 0.027 0.365 0.672 -0.029 -0.099 0.041 0.415 0.640LPC(22:4) [sn2] 0.047 -0.023 0.117 0.189 0.506 0.115 0.053 0.177 0.000 0.019 -0.043 -0.092 0.006 0.084 0.329 -0.088 -0.153 -0.022 0.009 0.084TG(O-52:0) [NL-16:0] -0.048 -0.120 0.024 0.190 0.507 0.017 -0.048 0.082 0.612 0.782 0.028 -0.022 0.078 0.276 0.596 -0.041 -0.108 0.027 0.236 0.446CE(22:0) 0.053 -0.027 0.133 0.191 0.508 0.036 -0.034 0.107 0.313 0.545 0.003 -0.049 0.056 0.902 0.961 -0.016 -0.089 0.057 0.667 0.823CA -0.042 -0.106 0.022 0.195 0.515 -0.012 -0.069 0.046 0.687 0.836 0.061 0.019 0.104 0.004 0.057 0.084 0.024 0.143 0.006 0.065Cer(d18:1/21:0) 0.049 -0.026 0.124 0.197 0.516 0.075 0.008 0.142 0.029 0.182 -0.058 -0.110 -0.007 0.027 0.185 -0.119 -0.188 -0.051 0.001 0.027DG(14:0_18:2) 0.067 -0.035 0.168 0.197 0.516 0.052 -0.039 0.142 0.262 0.493 -0.084 -0.152 -0.015 0.016 0.137 -0.098 -0.191 -0.005 0.038 0.182TG(56:7) [NL-20:5] -0.045 -0.114 0.023 0.196 0.516 -0.041 -0.102 0.021 0.193 0.429 0.033 -0.013 0.078 0.160 0.454 0.018 -0.045 0.082 0.577 0.759LPC(20:4) [sn2] 0.046 -0.024 0.117 0.198 0.516 0.053 -0.009 0.115 0.093 0.310 -0.005 -0.053 0.042 0.822 0.925 -0.080 -0.145 -0.015 0.017 0.115dhCer(d18:0/24:0) -0.051 -0.130 0.027 0.199 0.517 -0.029 -0.098 0.039 0.403 0.610 0.050 -0.001 0.101 0.057 0.270 0.062 -0.010 0.134 0.090 0.277LPE(22:6) [sn2] 0.048 -0.025 0.121 0.200 0.517 -0.038 -0.103 0.028 0.257 0.492 -0.009 -0.061 0.042 0.731 0.887 0.042 -0.025 0.109 0.216 0.422TG(52:4) [NL-18:2] 0.048 -0.026 0.122 0.201 0.520 0.080 0.010 0.149 0.025 0.169 -0.045 -0.101 0.012 0.121 0.391 -0.043 -0.116 0.029 0.240 0.451PC(16:1_22:6) 0.052 -0.029 0.133 0.207 0.521 -0.012 -0.083 0.058 0.734 0.868 0.005 -0.050 0.060 0.865 0.946 -0.067 -0.140 0.007 0.074 0.259PC(38:5) (a) 0.048 -0.026 0.122 0.205 0.521 0.085 0.021 0.148 0.009 0.099 -0.048 -0.099 0.003 0.065 0.290 -0.068 -0.135 -0.001 0.047 0.200PC(18:0_22:6) -0.046 -0.116 0.025 0.203 0.521 -0.079 -0.141 -0.016 0.014 0.116 0.044 -0.003 0.091 0.068 0.294 0.028 -0.037 0.093 0.391 0.615PE(P-16:0/22:5) (n6) -0.047 -0.119 0.025 0.203 0.521 0.057 -0.005 0.120 0.073 0.285 0.044 -0.009 0.096 0.101 0.364 -0.062 -0.128 0.003 0.062 0.234PI(18:0_20:3) (a) 0.042 -0.023 0.108 0.205 0.521 -0.001 -0.060 0.058 0.962 0.980 0.008 -0.035 0.052 0.707 0.875 0.054 -0.007 0.115 0.083 0.269PI(20:0_20:4) 0.044 -0.024 0.111 0.206 0.521 0.032 -0.028 0.093 0.296 0.528 0.016 -0.029 0.061 0.484 0.739 0.040 -0.022 0.103 0.208 0.415TG(O-50:1) [NL-18:1] -0.044 -0.113 0.024 0.206 0.521 -0.074 -0.135 -0.012 0.019 0.141 0.106 0.060 0.151 0.000 0.000 0.022 -0.042 0.085 0.501 0.701PC(O-40:5) 0.046 -0.026 0.118 0.209 0.525 0.085 0.021 0.149 0.009 0.099 -0.025 -0.077 0.028 0.356 0.667 -0.124 -0.190 -0.058 0.000 0.017Cer(m18:0/20:0) -0.054 -0.138 0.030 0.211 0.528 -0.013 -0.087 0.060 0.728 0.864 0.000 -0.056 0.057 0.988 0.994 -0.068 -0.144 0.009 0.083 0.269PC(O-16:0/20:3) 0.046 -0.026 0.118 0.211 0.528 0.073 0.011 0.136 0.022 0.152 0.008 -0.043 0.059 0.759 0.900 -0.060 -0.126 0.006 0.075 0.259PE(P-16:0/22:5) (n3) -0.047 -0.122 0.027 0.212 0.528 -0.008 -0.074 0.057 0.802 0.912 0.044 -0.006 0.094 0.082 0.325 0.017 -0.051 0.085 0.619 0.799Cer(m18:1/18:0) -0.050 -0.128 0.029 0.213 0.528 -0.025 -0.095 0.044 0.475 0.669 -0.010 -0.061 0.041 0.703 0.875 -0.025 -0.096 0.046 0.487 0.696DG(14:0_16:0) -0.059 -0.151 0.034 0.214 0.528 0.043 -0.038 0.125 0.295 0.528 -0.032 -0.095 0.031 0.314 0.628 -0.067 -0.153 0.019 0.125 0.325LPC(14:0) [sn1] 0.045 -0.027 0.117 0.216 0.529 0.049 -0.015 0.113 0.130 0.360 -0.055 -0.102 -0.007 0.025 0.177 -0.057 -0.124 0.009 0.092 0.278LPE(P-20:0) 0.043 -0.025 0.110 0.215 0.529 0.036 -0.024 0.096 0.236 0.480 -0.020 -0.064 0.024 0.370 0.672 -0.012 -0.074 0.050 0.701 0.840TG(O-52:2) [NL-16:0] -0.045 -0.116 0.026 0.216 0.529 -0.058 -0.122 0.006 0.075 0.286 0.133 0.084 0.181 0.000 0.000 0.054 -0.013 0.121 0.112 0.302Cer(d19:1/24:1) 0.041 -0.024 0.107 0.218 0.530 0.027 -0.031 0.086 0.363 0.580 -0.009 -0.052 0.035 0.699 0.875 -0.071 -0.132 -0.011 0.021 0.129PC(32:2) 0.052 -0.032 0.136 0.222 0.530 0.085 0.010 0.161 0.027 0.175 -0.064 -0.120 -0.007 0.027 0.185 -0.093 -0.171 -0.014 0.020 0.128PC(P-16:0/18:1) 0.065 -0.039 0.169 0.220 0.530 0.010 -0.082 0.101 0.836 0.932 0.027 -0.043 0.096 0.450 0.728 -0.042 -0.135 0.052 0.381 0.610PE(16:0_16:0) 0.049 -0.030 0.127 0.223 0.530 0.040 -0.030 0.111 0.257 0.492 -0.024 -0.077 0.029 0.379 0.678 -0.052 -0.125 0.021 0.165 0.371LPC(19:0) (a) [sn1] [104_sn1] 0.044 -0.027 0.115 0.224 0.530 0.005 -0.058 0.068 0.870 0.944 0.037 -0.011 0.086 0.129 0.407 -0.002 -0.067 0.063 0.958 0.977LPC(15:0) [sn1] 0.043 -0.026 0.111 0.226 0.530 0.033 -0.028 0.095 0.286 0.521 -0.013 -0.059 0.033 0.583 0.810 -0.026 -0.090 0.037 0.418 0.640PE(O-16:0/22:4) -0.044 -0.115 0.027 0.225 0.530 0.041 -0.022 0.105 0.204 0.446 0.008 -0.041 0.056 0.756 0.899 -0.061 -0.127 0.005 0.072 0.253PE(P-18:1/20:4) (a) -0.044 -0.113 0.026 0.218 0.530 -0.037 -0.098 0.024 0.236 0.480 0.087 0.041 0.133 0.000 0.007 0.011 -0.052 0.075 0.727 0.855LPI(18:1) [sn2] -0.041 -0.106 0.024 0.220 0.530 -0.012 -0.070 0.046 0.674 0.829 0.000 -0.044 0.044 1.000 1.000 0.001 -0.059 0.062 0.963 0.977AC(20:3) (b) 0.040 -0.025 0.105 0.225 0.530 0.054 -0.004 0.113 0.067 0.272 -0.015 -0.058 0.028 0.488 0.742 -0.039 -0.099 0.021 0.201 0.406TG(50:2) [NL-18:1] 0.049 -0.030 0.128 0.220 0.530 0.070 -0.003 0.143 0.060 0.259 -0.058 -0.114 -0.001 0.045 0.243 -0.063 -0.140 0.013 0.105 0.292TG(52:3) [NL-16:1] 0.042 -0.026 0.110 0.225 0.530 0.065 0.002 0.128 0.042 0.215 -0.016 -0.068 0.036 0.545 0.779 -0.069 -0.134 -0.003 0.039 0.183PC(34:2) [+OH] 0.048 -0.029 0.125 0.223 0.530 -0.053 -0.120 0.013 0.116 0.344 0.001 -0.048 0.050 0.967 0.985 -0.027 -0.097 0.043 0.446 0.661SM(40:3) (a) 0.051 -0.033 0.136 0.230 0.536 0.051 -0.023 0.124 0.178 0.421 -0.034 -0.091 0.023 0.239 0.552 -0.122 -0.198 -0.045 0.002 0.041PE(16:1_18:2) 0.047 -0.030 0.123 0.231 0.536 0.109 0.040 0.178 0.002 0.042 -0.036 -0.090 0.017 0.182 0.482 -0.074 -0.146 -0.002 0.044 0.193CE(20:0) 0.052 -0.033 0.138 0.231 0.536 0.040 -0.035 0.114 0.294 0.528 -0.009 -0.064 0.046 0.755 0.899 -0.053 -0.131 0.024 0.176 0.381DG(16:0_18:1) -0.070 -0.184 0.044 0.229 0.536 -0.045 -0.145 0.055 0.374 0.584 -0.032 -0.110 0.045 0.415 0.705 -0.079 -0.183 0.024 0.131 0.333TG(49:1) [NL-17:1] -0.047 -0.125 0.030 0.232 0.536 0.033 -0.038 0.103 0.362 0.580 -0.027 -0.081 0.026 0.314 0.628 -0.066 -0.140 0.008 0.078 0.265PI(18:0_18:1) -0.047 -0.123 0.030 0.233 0.537 -0.010 -0.078 0.058 0.780 0.897 0.055 0.004 0.106 0.035 0.211 0.009 -0.061 0.079 0.807 0.899PC(16:0_18:3) (b) 0.049 -0.032 0.130 0.236 0.540 0.121 0.049 0.193 0.001 0.034 -0.054 -0.111 0.003 0.061 0.282 -0.097 -0.172 -0.022 0.012 0.090LPC(22:6) [sn2] 0.042 -0.028 0.112 0.236 0.540 -0.051 -0.113 0.011 0.107 0.331 0.036 -0.010 0.083 0.124 0.397 -0.005 -0.069 0.059 0.874 0.931Cer(d20:1/22:0) -0.042 -0.112 0.028 0.237 0.540 -0.022 -0.085 0.040 0.480 0.674 0.026 -0.020 0.073 0.268 0.588 -0.017 -0.081 0.048 0.606 0.789TG(48:0) [NL-16:0] -0.046 -0.122 0.030 0.237 0.540 -0.001 -0.070 0.069 0.987 0.990 -0.024 -0.076 0.029 0.381 0.678 -0.022 -0.095 0.052 0.562 0.750PC(28:0) 0.042 -0.029 0.113 0.242 0.543 0.063 0.000 0.126 0.051 0.241 -0.054 -0.101 -0.006 0.026 0.181 -0.055 -0.121 0.010 0.099 0.284PE(P-18:1/22:6) (a) -0.042 -0.112 0.028 0.239 0.543 -0.118 -0.180 -0.056 0.000 0.016 0.113 0.066 0.159 0.000 0.000 0.043 -0.022 0.107 0.192 0.397PE(P-16:0/18:1) -0.044 -0.119 0.030 0.242 0.543 -0.060 -0.125 0.006 0.073 0.285 0.086 0.038 0.134 0.001 0.013 0.089 0.022 0.156 0.009 0.088CE(18:3) 0.062 -0.042 0.166 0.240 0.543 0.076 -0.015 0.166 0.100 0.317 -0.019 -0.085 0.047 0.566 0.797 0.009 -0.084 0.102 0.854 0.918DG(18:1_20:4) -0.054 -0.145 0.037 0.241 0.543 -0.018 -0.098 0.063 0.667 0.823 0.022 -0.039 0.082 0.484 0.739 -0.066 -0.150 0.018 0.123 0.322Cer(m18:0/23:0) -0.048 -0.130 0.033 0.244 0.543 -0.005 -0.075 0.066 0.900 0.960 0.019 -0.035 0.072 0.498 0.753 -0.029 -0.103 0.045 0.439 0.656FA(16:0) -0.040 -0.106 0.027 0.244 0.543 -0.036 -0.095 0.024 0.238 0.481 0.014 -0.030 0.058 0.537 0.779 -0.027 -0.088 0.034 0.386 0.611LPC(18:0) [sn2] 0.043 -0.029 0.115 0.245 0.544 0.014 -0.051 0.078 0.675 0.829 0.010 -0.041 0.060 0.708 0.875 -0.024 -0.091 0.043 0.489 0.696PE(P-16:0/18:2) -0.042 -0.114 0.029 0.245 0.544 -0.012 -0.075 0.051 0.701 0.848 0.061 0.013 0.108 0.012 0.114 0.063 -0.003 0.128 0.061 0.232PC(18:0_22:5) (n6) -0.045 -0.122 0.031 0.248 0.546 0.089 0.021 0.157 0.010 0.104 -0.013 -0.066 0.040 0.630 0.829 -0.072 -0.143 0.000 0.050 0.204PE(P-18:1/22:6) (b) -0.041 -0.111 0.029 0.250 0.546 0.000 -0.060 0.061 0.995 0.995 0.058 0.004 0.112 0.034 0.210 -0.060 -0.122 0.002 0.058 0.224CE(24:0) 0.047 -0.033 0.126 0.250 0.546 0.013 -0.057 0.083 0.724 0.864 -0.001 -0.053 0.051 0.969 0.986 -0.023 -0.095 0.050 0.536 0.729DG(18:1_20:5) -0.044 -0.119 0.031 0.248 0.546 -0.058 -0.125 0.008 0.083 0.301 0.019 -0.030 0.068 0.456 0.730 -0.013 -0.083 0.056 0.704 0.840TG(51:1) [NL-17:0] -0.053 -0.142 0.037 0.247 0.546 0.022 -0.060 0.103 0.604 0.778 -0.051 -0.113 0.011 0.106 0.368 -0.066 -0.152 0.020 0.132 0.333CE(20:5) -0.051 -0.138 0.036 0.251 0.546 -0.101 -0.180 -0.022 0.012 0.110 0.024 -0.035 0.083 0.431 0.715 0.051 -0.030 0.132 0.219 0.426FA(17:1) -0.039 -0.105 0.027 0.252 0.547 -0.011 -0.071 0.048 0.705 0.851 -0.014 -0.061 0.032 0.549 0.783 -0.032 -0.094 0.029 0.301 0.522AC(24:0) -0.039 -0.107 0.028 0.253 0.548 -0.053 -0.113 0.007 0.085 0.302 0.056 0.012 0.101 0.014 0.124 0.053 -0.009 0.115 0.096 0.279Cer(d18:2/20:0) 0.043 -0.031 0.118 0.256 0.551 0.050 -0.017 0.117 0.142 0.376 -0.025 -0.075 0.026 0.340 0.648 -0.033 -0.103 0.037 0.357 0.584dimethyl-CE(20:4) -0.044 -0.120 0.032 0.256 0.551 -0.022 -0.091 0.047 0.528 0.719 0.067 0.016 0.119 0.010 0.104 0.048 -0.022 0.119 0.179 0.386PI(18:0_22:6) -0.043 -0.118 0.031 0.257 0.551 -0.071 -0.136 -0.005 0.035 0.196 0.040 -0.010 0.090 0.119 0.391 -0.013 -0.081 0.054 0.697 0.840SHexCer(d18:1/16:0(OH)) 0.044 -0.032 0.120 0.261 0.558 0.013 -0.055 0.080 0.715 0.858 -0.028 -0.078 0.023 0.280 0.601 -0.110 -0.180 -0.041 0.002 0.041PC(P-16:0/20:5) -0.041 -0.114 0.031 0.264 0.562 -0.092 -0.158 -0.026 0.006 0.082 0.045 -0.004 0.093 0.072 0.302 0.050 -0.017 0.117 0.142 0.347PC(16:0_16:0) 0.054 -0.041 0.148 0.264 0.562 0.064 -0.018 0.147 0.128 0.358 -0.032 -0.097 0.033 0.333 0.646 -0.116 -0.202 -0.030 0.008 0.082SM(35:2) (b) -0.053 -0.146 0.040 0.266 0.562 0.039 -0.039 0.117 0.329 0.563 0.029 -0.043 0.101 0.428 0.713 -0.137 -0.218 -0.055 0.001 0.028PE(16:0_22:6) -0.044 -0.121 0.034 0.267 0.562 -0.082 -0.152 -0.013 0.021 0.149 0.006 -0.046 0.059 0.815 0.925 -0.001 -0.073 0.071 0.975 0.984FA(14:0) -0.038 -0.104 0.029 0.267 0.562 0.025 -0.035 0.085 0.412 0.617 -0.017 -0.061 0.027 0.450 0.728 -0.080 -0.141 -0.018 0.011 0.090TG(54:6) [NL-20:5] -0.041 -0.113 0.031 0.267 0.562 -0.035 -0.099 0.030 0.289 0.525 0.011 -0.037 0.059 0.657 0.849 0.004 -0.063 0.071 0.903 0.948Cer(d18:2/26:0) 0.043 -0.033 0.118 0.271 0.567 -0.011 -0.079 0.057 0.761 0.885 0.025 -0.025 0.074 0.328 0.641 0.009 -0.060 0.078 0.793 0.890PE(15-MHDA_18:2) 0.042 -0.033 0.117 0.272 0.567 0.063 -0.005 0.131 0.071 0.282 -0.026 -0.076 0.025 0.321 0.635 -0.072 -0.142 -0.002 0.043 0.191LPC(24:0) [sn2] 0.042 -0.033 0.117 0.273 0.567 -0.020 -0.086 0.047 0.562 0.746 0.028 -0.020 0.077 0.252 0.572 0.063 -0.004 0.131 0.065 0.245PC(P-38:5) (b) -0.041 -0.113 0.032 0.274 0.567 0.037 -0.026 0.100 0.246 0.491 0.018 -0.038 0.073 0.528 0.773 -0.072 -0.137 -0.008 0.029 0.154PS(40:6) -0.037 -0.103 0.029 0.272 0.567 -0.065 -0.124 -0.005 0.033 0.190 0.023 -0.021 0.067 0.298 0.616 0.036 -0.024 0.097 0.242 0.453TG(50:1) [NL-18:1] -0.046 -0.127 0.036 0.275 0.567 0.036 -0.040 0.112 0.354 0.576 -0.029 -0.086 0.029 0.332 0.646 -0.028 -0.109 0.052 0.491 0.696TG(O-50:1) [NL-16:0] -0.039 -0.110 0.031 0.274 0.567 -0.037 -0.101 0.026 0.251 0.492 0.096 0.048 0.143 0.000 0.003 0.021 -0.045 0.087 0.526 0.725TG(56:6) [NL-20:4] -0.037 -0.104 0.030 0.276 0.568 0.010 -0.048 0.069 0.730 0.865 0.048 0.002 0.093 0.039 0.220 -0.006 -0.068 0.056 0.844 0.916Cer(d19:1/26:0) 0.037 -0.030 0.103 0.280 0.571 0.028 -0.031 0.087 0.353 0.576 0.002 -0.041 0.046 0.921 0.966 0.007 -0.054 0.068 0.827 0.909HexCer(d16:1/18:0) 0.037 -0.030 0.103 0.279 0.571 0.048 -0.011 0.107 0.109 0.331 -0.047 -0.090 -0.003 0.036 0.212 -0.025 -0.086 0.036 0.423 0.642PG(36:1) -0.057 -0.160 0.046 0.279 0.571 -0.052 -0.142 0.037 0.252 0.492 0.022 -0.044 0.089 0.505 0.757 0.044 -0.048 0.136 0.351 0.576PE(16:1_20:4) 0.044 -0.036 0.125 0.282 0.572 0.115 0.044 0.186 0.002 0.037 -0.077 -0.131 -0.024 0.005 0.057 -0.110 -0.184 -0.035 0.004 0.055AC(20:4) 0.036 -0.030 0.102 0.282 0.572 0.040 -0.020 0.099 0.193 0.429 -0.012 -0.056 0.032 0.593 0.811 -0.023 -0.084 0.039 0.470 0.685FA(22:4) -0.037 -0.104 0.031 0.283 0.572 0.009 -0.051 0.068 0.780 0.897 -0.007 -0.052 0.038 0.758 0.899 -0.067 -0.129 -0.006 0.033 0.167TG(54:4) [NL-18:2] 0.037 -0.030 0.104 0.281 0.572 0.033 -0.029 0.096 0.297 0.528 0.012 -0.039 0.062 0.652 0.848 -0.010 -0.075 0.056 0.776 0.878PC(18:0_20:4) -0.040 -0.114 0.034 0.288 0.579 0.023 -0.042 0.088 0.481 0.674 -0.004 -0.053 0.046 0.883 0.953 -0.060 -0.129 0.008 0.084 0.270TG(56:9) [NL-22:6] -0.039 -0.112 0.033 0.289 0.580 -0.064 -0.129 0.000 0.051 0.241 0.033 -0.016 0.081 0.188 0.486 -0.015 -0.082 0.053 0.666 0.823TG(48:0) [NL-18:0] -0.039 -0.110 0.033 0.290 0.581 0.010 -0.055 0.075 0.762 0.885 -0.040 -0.089 0.010 0.115 0.387 -0.046 -0.114 0.023 0.194 0.398Cer(d18:2/14:0) 0.044 -0.038 0.127 0.293 0.584 0.022 -0.048 0.092 0.539 0.729 -0.043 -0.096 0.009 0.104 0.368 -0.041 -0.114 0.032 0.265 0.473Cer(d20:1/23:0) -0.037 -0.106 0.032 0.294 0.587 -0.045 -0.107 0.017 0.153 0.385 0.013 -0.034 0.059 0.585 0.810 -0.015 -0.079 0.049 0.652 0.816FA(16:1) -0.037 -0.107 0.033 0.296 0.589 0.040 -0.023 0.102 0.215 0.456 -0.025 -0.071 0.022 0.303 0.620 -0.097 -0.162 -0.032 0.003 0.049TG(O-50:1) [NL-15:0] -0.037 -0.107 0.033 0.298 0.591 -0.054 -0.117 0.009 0.094 0.310 0.079 0.032 0.127 0.001 0.022 -0.004 -0.069 0.061 0.903 0.948CE(20:1) 0.047 -0.042 0.137 0.299 0.591 0.010 -0.067 0.087 0.801 0.912 0.008 -0.050 0.066 0.775 0.904 -0.084 -0.165 -0.004 0.041 0.185PE(P-20:0/18:1) -0.037 -0.106 0.033 0.300 0.591 -0.057 -0.119 0.005 0.071 0.282 0.061 0.016 0.106 0.008 0.091 0.063 -0.001 0.126 0.053 0.210Cer(d16:1/24:0) 0.039 -0.035 0.113 0.302 0.594 0.041 -0.024 0.106 0.213 0.456 0.004 -0.044 0.052 0.871 0.949 0.023 -0.045 0.090 0.506 0.704PC(O-32:2) -0.038 -0.111 0.035 0.303 0.594 -0.041 -0.106 0.024 0.213 0.456 0.017 -0.031 0.066 0.483 0.739 0.004 -0.063 0.071 0.900 0.948PC(35:5) -0.038 -0.111 0.035 0.304 0.594 -0.036 -0.101 0.029 0.281 0.515 -0.006 -0.055 0.042 0.797 0.915 0.011 -0.057 0.079 0.757 0.874TG(54:3) [NL-18:1] 0.036 -0.032 0.104 0.304 0.594 -0.002 -0.065 0.062 0.962 0.980 0.030 -0.019 0.079 0.234 0.546 0.013 -0.053 0.079 0.695 0.840PE(P-18:0/18:2) -0.038 -0.110 0.035 0.307 0.595 -0.002 -0.066 0.062 0.945 0.977 0.042 -0.006 0.090 0.090 0.340 0.039 -0.027 0.106 0.248 0.459LPI(18:0) [sn2] -0.035 -0.101 0.032 0.306 0.595 -0.016 -0.074 0.043 0.595 0.775 -0.018 -0.062 0.025 0.404 0.693 0.016 -0.046 0.077 0.618 0.799LPI(18:2) [sn1] -0.035 -0.101 0.032 0.307 0.595 0.041 -0.018 0.100 0.172 0.410 0.014 -0.031 0.059 0.542 0.779 -0.018 -0.079 0.044 0.573 0.758PE(18:0_22:4) -0.043 -0.126 0.040 0.311 0.599 0.053 -0.021 0.128 0.160 0.397 -0.058 -0.115 -0.001 0.046 0.243 -0.072 -0.150 0.006 0.070 0.250PE(P-18:0/20:3) (a) -0.035 -0.103 0.033 0.311 0.599 -0.003 -0.063 0.057 0.922 0.964 0.042 -0.004 0.087 0.071 0.302 0.032 -0.030 0.094 0.312 0.538PC(O-35:4) -0.035 -0.102 0.033 0.312 0.599 0.005 -0.055 0.065 0.882 0.949 0.044 -0.001 0.089 0.054 0.263 -0.021 -0.083 0.041 0.504 0.703FA(22:6) -0.035 -0.104 0.033 0.313 0.600 -0.079 -0.141 -0.018 0.012 0.107 0.047 0.002 0.093 0.042 0.229 0.018 -0.045 0.082 0.574 0.758PC(P-16:0/16:1) 0.047 -0.045 0.139 0.315 0.600 0.082 0.001 0.162 0.047 0.227 -0.058 -0.121 0.005 0.070 0.302 -0.087 -0.171 -0.003 0.042 0.188PE(18:0_20:4) -0.045 -0.132 0.042 0.314 0.600 0.004 -0.075 0.083 0.930 0.968 -0.040 -0.099 0.019 0.183 0.482 -0.059 -0.140 0.022 0.152 0.358DE(18:1) -0.035 -0.104 0.034 0.319 0.607 0.011 -0.051 0.073 0.722 0.864 -0.016 -0.063 0.032 0.523 0.773 -0.015 -0.080 0.049 0.641 0.810PE(P-18:1/20:4) (b) -0.033 -0.099 0.033 0.324 0.613 0.044 -0.015 0.102 0.141 0.375 0.034 -0.017 0.084 0.187 0.485 -0.075 -0.136 -0.014 0.015 0.110 ### Page 16 TG(50:3) [NL-14:1] 0.040 -0.040 0.121 0.325 0.613 0.078 0.004 0.151 0.038 0.204 -0.045 -0.105 0.015 0.145 0.427 -0.106 -0.182 -0.030 0.006 0.069TG(48:2) [NL-18:2] 0.044 -0.043 0.130 0.324 0.613 0.070 -0.011 0.151 0.090 0.310 -0.060 -0.122 0.001 0.054 0.263 -0.075 -0.160 0.010 0.083 0.269Cer(d16:1/23:0) 0.037 -0.037 0.111 0.327 0.613 0.052 -0.013 0.118 0.117 0.344 -0.014 -0.063 0.034 0.567 0.797 -0.017 -0.085 0.050 0.620 0.800CE(24:5) -0.041 -0.123 0.041 0.326 0.613 -0.013 -0.085 0.059 0.726 0.864 0.028 -0.025 0.081 0.298 0.616 0.054 -0.021 0.129 0.156 0.359S1P(d18:2) 0.033 -0.034 0.101 0.329 0.615 0.066 0.006 0.125 0.031 0.188 0.015 -0.031 0.061 0.529 0.773 -0.012 -0.073 0.050 0.709 0.841CE(24:4) 0.042 -0.043 0.127 0.329 0.615 0.056 -0.019 0.130 0.145 0.380 0.000 -0.055 0.056 0.993 0.994 -0.057 -0.135 0.021 0.154 0.359PE(17:0_22:6) -0.039 -0.117 0.040 0.331 0.615 -0.096 -0.166 -0.025 0.008 0.095 0.033 -0.020 0.086 0.218 0.530 0.028 -0.045 0.100 0.451 0.666PI(38:5) (a) 0.039 -0.040 0.117 0.330 0.615 0.117 0.046 0.187 0.001 0.036 -0.009 -0.062 0.044 0.743 0.892 -0.047 -0.119 0.026 0.208 0.415AC(16:0)-OH -0.032 -0.098 0.033 0.335 0.621 0.004 -0.055 0.063 0.898 0.960 -0.025 -0.069 0.019 0.270 0.588 -0.102 -0.162 -0.041 0.001 0.028DG(18:0_18:2) -0.055 -0.167 0.057 0.336 0.621 -0.054 -0.149 0.042 0.272 0.507 -0.055 -0.132 0.022 0.161 0.454 -0.092 -0.192 0.008 0.070 0.250PC(P-35:2) (a) 0.037 -0.039 0.113 0.340 0.628 0.050 -0.016 0.116 0.136 0.369 0.039 -0.010 0.089 0.120 0.391 -0.008 -0.077 0.062 0.824 0.909Cer(d18:1/19:0) 0.032 -0.035 0.098 0.352 0.630 -0.002 -0.062 0.058 0.948 0.977 -0.002 -0.046 0.043 0.941 0.973 -0.005 -0.067 0.057 0.868 0.929SM(d17:1/24:1) 0.037 -0.040 0.114 0.346 0.630 0.004 -0.064 0.072 0.906 0.960 0.036 -0.015 0.087 0.165 0.457 -0.063 -0.135 0.008 0.082 0.269PC(16:0_20:5) -0.035 -0.109 0.039 0.352 0.630 -0.046 -0.113 0.020 0.170 0.407 -0.015 -0.064 0.034 0.553 0.783 -0.008 -0.077 0.061 0.818 0.907PA(36:3) 0.033 -0.036 0.101 0.349 0.630 -0.003 -0.063 0.056 0.917 0.964 0.015 -0.030 0.060 0.515 0.768 0.065 0.003 0.127 0.040 0.185PC(P-18:0/22:6) -0.037 -0.115 0.040 0.347 0.630 -0.101 -0.169 -0.033 0.004 0.060 0.075 0.024 0.126 0.004 0.057 0.016 -0.054 0.086 0.651 0.816PC(P-35:2) (b) 0.036 -0.039 0.111 0.348 0.630 0.021 -0.044 0.087 0.524 0.716 0.037 -0.013 0.087 0.146 0.429 -0.022 -0.091 0.047 0.533 0.729LPC(15:0) [sn2] 0.033 -0.036 0.101 0.351 0.630 0.034 -0.027 0.095 0.279 0.514 -0.017 -0.063 0.029 0.458 0.730 -0.025 -0.088 0.038 0.434 0.651PI(16:0_16:1) -0.036 -0.112 0.040 0.351 0.630 0.064 -0.004 0.132 0.066 0.272 -0.035 -0.085 0.016 0.180 0.479 -0.058 -0.129 0.013 0.111 0.301PI(18:0_22:4) -0.038 -0.118 0.041 0.344 0.630 0.068 -0.002 0.138 0.056 0.254 -0.029 -0.084 0.026 0.298 0.616 -0.060 -0.134 0.014 0.110 0.301PE(P-16:0/20:3) (a) -0.033 -0.102 0.035 0.344 0.630 -0.015 -0.075 0.045 0.617 0.783 0.054 0.009 0.099 0.019 0.154 0.045 -0.017 0.108 0.155 0.359FA(17:0) -0.031 -0.095 0.034 0.347 0.630 0.007 -0.050 0.065 0.804 0.913 0.000 -0.043 0.043 0.993 0.994 -0.087 -0.146 -0.027 0.004 0.057AC(22:6) -0.032 -0.100 0.036 0.350 0.630 -0.087 -0.148 -0.026 0.005 0.077 0.037 -0.010 0.084 0.124 0.397 0.057 -0.006 0.121 0.077 0.264COH 0.042 -0.045 0.129 0.344 0.630 -0.003 -0.077 0.071 0.935 0.970 0.007 -0.054 0.068 0.823 0.925 -0.100 -0.180 -0.020 0.014 0.104AC(12:1) -0.031 -0.096 0.034 0.354 0.631 0.045 -0.014 0.104 0.132 0.362 -0.009 -0.054 0.035 0.676 0.860 -0.068 -0.129 -0.008 0.027 0.153PE(18:1_18:2) 0.033 -0.037 0.104 0.355 0.631 0.029 -0.036 0.095 0.376 0.586 0.016 -0.033 0.065 0.520 0.773 0.019 -0.048 0.087 0.573 0.758SM(43:2) (c) -0.040 -0.125 0.045 0.357 0.633 -0.054 -0.129 0.021 0.160 0.397 0.093 0.038 0.149 0.001 0.021 0.050 -0.029 0.129 0.212 0.422LPC(26:0) [sn2] 0.039 -0.044 0.123 0.357 0.633 -0.018 -0.091 0.055 0.629 0.789 0.007 -0.046 0.061 0.790 0.912 0.073 -0.001 0.148 0.053 0.212Cer(d18:1/22:0) 0.037 -0.043 0.118 0.361 0.635 0.066 -0.005 0.138 0.067 0.272 -0.010 -0.065 0.045 0.732 0.887 -0.075 -0.149 -0.001 0.047 0.200PC(36:4) [+OH] -0.033 -0.102 0.037 0.360 0.635 0.021 -0.041 0.083 0.512 0.705 -0.002 -0.050 0.045 0.925 0.968 -0.102 -0.166 -0.037 0.002 0.041S1P(d16:1) 0.031 -0.037 0.099 0.369 0.641 0.079 0.019 0.139 0.010 0.100 -0.012 -0.057 0.032 0.591 0.811 -0.004 -0.066 0.058 0.906 0.948PC(15-MHDA_18:2) 0.035 -0.042 0.112 0.372 0.641 0.056 -0.012 0.125 0.108 0.331 0.020 -0.032 0.072 0.459 0.730 -0.045 -0.116 0.026 0.215 0.422PE(18:0_20:3) (b) -0.036 -0.114 0.042 0.365 0.641 0.006 -0.063 0.076 0.857 0.940 -0.045 -0.097 0.008 0.095 0.346 -0.082 -0.155 -0.009 0.027 0.153PE(18:1_22:6) (b) -0.036 -0.114 0.043 0.369 0.641 0.020 -0.048 0.088 0.570 0.754 -0.025 -0.081 0.031 0.384 0.678 -0.062 -0.131 0.008 0.082 0.269PE(P-20:0/22:6) -0.034 -0.107 0.040 0.370 0.641 -0.130 -0.195 -0.064 0.000 0.016 0.057 0.009 0.105 0.021 0.158 0.021 -0.046 0.088 0.534 0.729LPE(P-18:1) 0.030 -0.036 0.096 0.370 0.641 0.049 -0.010 0.107 0.104 0.327 0.028 -0.023 0.078 0.281 0.601 -0.028 -0.089 0.033 0.368 0.597AC(20:3)-OH 0.030 -0.036 0.097 0.367 0.641 0.046 -0.012 0.105 0.122 0.351 -0.006 -0.050 0.039 0.803 0.918 -0.023 -0.085 0.038 0.454 0.668DG(16:0_20:4) -0.041 -0.132 0.050 0.372 0.641 -0.008 -0.089 0.073 0.845 0.937 -0.001 -0.063 0.060 0.962 0.983 -0.075 -0.160 0.010 0.083 0.269TG(56:7) [NL-22:5] -0.034 -0.107 0.040 0.371 0.641 0.011 -0.056 0.079 0.742 0.871 -0.024 -0.076 0.028 0.364 0.671 -0.055 -0.125 0.015 0.122 0.322PC(18:0_22:4) -0.034 -0.110 0.041 0.373 0.642 0.090 0.023 0.157 0.008 0.096 -0.036 -0.089 0.016 0.177 0.476 -0.071 -0.142 0.000 0.050 0.204Sph(d18:1) 0.029 -0.035 0.092 0.379 0.651 0.021 -0.036 0.079 0.466 0.662 -0.005 -0.047 0.038 0.835 0.930 -0.014 -0.073 0.045 0.651 0.816SM(44:3) 0.038 -0.047 0.123 0.380 0.651 0.005 -0.069 0.079 0.890 0.954 -0.012 -0.067 0.042 0.659 0.849 -0.031 -0.109 0.047 0.440 0.657TG(56:6) [NL-22:5] -0.033 -0.106 0.041 0.381 0.652 0.004 -0.062 0.070 0.904 0.960 -0.012 -0.063 0.038 0.635 0.834 -0.022 -0.091 0.048 0.543 0.733PS(36:1) 0.028 -0.035 0.092 0.383 0.654 0.034 -0.023 0.091 0.240 0.482 -0.004 -0.046 0.038 0.842 0.932 0.019 -0.039 0.078 0.516 0.717Cer(d18:2/16:0) 0.035 -0.045 0.115 0.389 0.658 0.038 -0.033 0.109 0.298 0.529 -0.026 -0.081 0.029 0.350 0.660 -0.050 -0.124 0.024 0.184 0.389PC(O-18:0/18:1) 0.035 -0.044 0.114 0.388 0.658 0.062 -0.009 0.132 0.085 0.302 -0.005 -0.062 0.053 0.866 0.946 -0.078 -0.152 -0.004 0.039 0.183CE(16:2) 0.043 -0.054 0.140 0.387 0.658 0.090 0.008 0.172 0.031 0.188 -0.051 -0.113 0.011 0.105 0.368 -0.053 -0.136 0.031 0.214 0.422SM(d18:1/20:0) & SM(d16:1/22:0) -0.038 -0.125 0.049 0.391 0.660 0.044 -0.033 0.120 0.261 0.493 0.058 -0.001 0.117 0.053 0.259 0.036 -0.046 0.119 0.384 0.611PC(O-18:0/22:6) -0.032 -0.105 0.041 0.392 0.660 -0.034 -0.099 0.031 0.308 0.541 0.032 -0.019 0.083 0.223 0.534 -0.055 -0.122 0.012 0.108 0.298CE(22:1) 0.034 -0.044 0.113 0.392 0.660 -0.024 -0.092 0.044 0.488 0.682 0.001 -0.049 0.052 0.954 0.980 -0.074 -0.146 -0.002 0.045 0.194TG(48:1) [NL-16:1] -0.033 -0.111 0.044 0.394 0.660 0.040 -0.030 0.111 0.260 0.493 -0.042 -0.095 0.012 0.128 0.407 -0.054 -0.128 0.020 0.152 0.358TG(O-54:4) [NL-17:1] -0.030 -0.098 0.038 0.394 0.660 -0.029 -0.089 0.032 0.352 0.576 0.106 0.058 0.154 0.000 0.001 0.012 -0.051 0.075 0.716 0.845PC(O-18:0/18:2) 0.034 -0.045 0.113 0.397 0.662 0.071 0.002 0.140 0.043 0.217 -0.008 -0.064 0.047 0.766 0.902 -0.057 -0.130 0.015 0.123 0.322PE(P-18:1/20:3) (a) -0.030 -0.101 0.040 0.397 0.662 0.005 -0.057 0.067 0.867 0.943 0.087 0.040 0.135 0.000 0.008 0.044 -0.021 0.108 0.181 0.386FA(18:1) -0.029 -0.096 0.038 0.398 0.662 -0.040 -0.100 0.020 0.189 0.426 0.007 -0.038 0.051 0.772 0.902 -0.055 -0.117 0.007 0.084 0.270PE(P-18:1/20:3) (b) -0.029 -0.098 0.039 0.401 0.665 0.025 -0.036 0.086 0.414 0.617 0.049 -0.001 0.098 0.055 0.264 -0.028 -0.091 0.035 0.387 0.611TG(48:2) [NL-14:0] 0.038 -0.051 0.128 0.401 0.665 0.091 0.008 0.173 0.032 0.188 -0.083 -0.146 -0.020 0.009 0.100 -0.087 -0.174 0.000 0.049 0.204PC(O-36:5) -0.030 -0.100 0.040 0.406 0.671 -0.061 -0.124 0.002 0.058 0.254 0.024 -0.023 0.070 0.316 0.629 0.023 -0.041 0.088 0.478 0.689Hex3Cer(d18:1/16:0) 0.037 -0.052 0.127 0.415 0.673 0.033 -0.045 0.112 0.403 0.610 -0.047 -0.111 0.016 0.145 0.427 -0.171 -0.251 -0.090 0.000 0.011Cer(m18:1/20:0) -0.036 -0.122 0.050 0.409 0.673 -0.012 -0.088 0.063 0.752 0.878 -0.025 -0.081 0.031 0.377 0.678 -0.047 -0.124 0.031 0.237 0.447PC(O-32:1) -0.029 -0.098 0.041 0.415 0.673 -0.060 -0.121 0.002 0.058 0.254 0.038 -0.010 0.085 0.118 0.391 0.016 -0.048 0.080 0.631 0.806SM(d18:2/22:0) -0.038 -0.131 0.054 0.417 0.673 0.037 -0.043 0.117 0.365 0.581 0.029 -0.035 0.093 0.368 0.672 0.009 -0.077 0.094 0.845 0.916PC(38:6) (a) 0.038 -0.053 0.128 0.414 0.673 0.054 -0.022 0.130 0.166 0.399 0.025 -0.036 0.086 0.419 0.709 -0.039 -0.120 0.042 0.343 0.570PE(16:0_18:1) -0.034 -0.115 0.047 0.411 0.673 0.046 -0.029 0.121 0.232 0.475 -0.023 -0.080 0.034 0.428 0.713 -0.021 -0.099 0.056 0.586 0.767PE(P-18:0/22:4) -0.029 -0.099 0.041 0.412 0.673 0.090 0.027 0.153 0.005 0.075 -0.013 -0.062 0.035 0.594 0.811 -0.046 -0.112 0.020 0.169 0.372PIP1(38:4) 0.027 -0.038 0.092 0.416 0.673 0.050 -0.008 0.108 0.093 0.310 0.012 -0.031 0.056 0.578 0.806 0.003 -0.057 0.063 0.930 0.962CE(18:0) -0.040 -0.134 0.055 0.412 0.673 0.031 -0.050 0.113 0.451 0.653 -0.021 -0.086 0.044 0.527 0.773 -0.121 -0.207 -0.035 0.006 0.065TG(50:1) [NL-16:0] -0.034 -0.116 0.048 0.416 0.673 0.037 -0.039 0.113 0.341 0.572 -0.027 -0.085 0.031 0.366 0.672 -0.028 -0.109 0.053 0.501 0.701TG(O-50:1) [NL-17:1] -0.029 -0.097 0.040 0.413 0.673 -0.042 -0.103 0.020 0.183 0.425 0.094 0.047 0.141 0.000 0.004 0.000 -0.064 0.064 0.992 0.996S1P(d18:0) 0.026 -0.038 0.091 0.422 0.680 0.048 -0.009 0.106 0.098 0.312 -0.029 -0.073 0.015 0.199 0.502 -0.009 -0.069 0.050 0.762 0.874PC(39:5) (b) 0.030 -0.044 0.103 0.425 0.681 0.020 -0.046 0.085 0.554 0.742 -0.017 -0.066 0.031 0.485 0.740 -0.007 -0.075 0.061 0.836 0.912PS(38:4) 0.026 -0.038 0.090 0.425 0.681 0.051 -0.006 0.108 0.081 0.295 -0.029 -0.071 0.014 0.184 0.482 -0.009 -0.068 0.050 0.766 0.874Cer(d20:1/24:0) -0.028 -0.097 0.041 0.428 0.684 -0.015 -0.076 0.047 0.640 0.799 0.017 -0.029 0.064 0.471 0.737 -0.027 -0.091 0.037 0.406 0.632PC(18:1_20:3) 0.032 -0.048 0.113 0.429 0.685 0.080 0.010 0.151 0.026 0.173 0.044 -0.013 0.100 0.132 0.412 0.000 -0.075 0.074 0.998 0.998PE(P-18:1/18:1) (b) -0.027 -0.095 0.040 0.431 0.686 0.029 -0.031 0.089 0.342 0.572 0.045 -0.006 0.096 0.084 0.329 -0.045 -0.107 0.017 0.155 0.359Hex3Cer(d18:1/18:0) -0.031 -0.109 0.047 0.432 0.687 0.031 -0.039 0.100 0.386 0.594 -0.019 -0.072 0.034 0.478 0.737 -0.061 -0.133 0.010 0.092 0.278Cer(d16:1/20:0) 0.029 -0.045 0.103 0.441 0.695 0.046 -0.019 0.112 0.164 0.398 -0.015 -0.063 0.033 0.535 0.779 0.008 -0.060 0.076 0.823 0.909dhCer(d18:0/24:1) -0.028 -0.100 0.044 0.443 0.695 -0.043 -0.107 0.020 0.177 0.420 0.018 -0.030 0.065 0.465 0.732 -0.035 -0.101 0.031 0.297 0.518Cer(d17:1/22:0) 0.028 -0.045 0.101 0.446 0.695 0.069 0.004 0.135 0.037 0.199 0.006 -0.043 0.055 0.818 0.925 -0.010 -0.078 0.058 0.767 0.874SM(d18:2/20:0) -0.031 -0.111 0.048 0.440 0.695 0.033 -0.037 0.104 0.354 0.576 0.023 -0.032 0.079 0.408 0.697 -0.001 -0.075 0.073 0.972 0.982PC(P-18:0/20:4) -0.029 -0.105 0.046 0.443 0.695 0.031 -0.035 0.096 0.364 0.580 0.035 -0.016 0.087 0.174 0.473 -0.045 -0.114 0.023 0.195 0.398PI(18:0_20:3) (b) -0.028 -0.101 0.044 0.443 0.695 0.040 -0.025 0.104 0.230 0.475 0.011 -0.039 0.061 0.669 0.855 -0.030 -0.097 0.038 0.391 0.615PI(37:6) 0.028 -0.044 0.101 0.446 0.695 -0.051 -0.115 0.013 0.118 0.346 0.000 -0.047 0.047 0.985 0.993 -0.002 -0.068 0.064 0.956 0.977FA(22:5) -0.027 -0.095 0.042 0.444 0.695 -0.034 -0.095 0.027 0.278 0.514 0.011 -0.037 0.058 0.661 0.850 0.011 -0.053 0.074 0.741 0.863AC(15:0) (b) -0.025 -0.090 0.040 0.445 0.695 0.010 -0.048 0.068 0.725 0.864 -0.034 -0.077 0.009 0.121 0.391 -0.029 -0.088 0.031 0.349 0.575dimethyl-CE(22:6) -0.029 -0.103 0.045 0.442 0.695 -0.073 -0.138 -0.008 0.028 0.182 0.074 0.026 0.121 0.002 0.039 0.074 0.008 0.141 0.029 0.155TG(O-54:3) [NL-18:1] -0.026 -0.094 0.042 0.448 0.697 -0.042 -0.103 0.020 0.183 0.425 0.132 0.083 0.180 0.000 0.000 0.041 -0.024 0.105 0.216 0.422methyl-CE(20:4) -0.028 -0.100 0.045 0.451 0.699 0.008 -0.058 0.073 0.822 0.922 0.052 0.003 0.101 0.037 0.212 0.002 -0.065 0.070 0.947 0.973PE(17:0_18:1) -0.031 -0.111 0.050 0.453 0.701 0.033 -0.040 0.105 0.377 0.587 -0.003 -0.058 0.051 0.903 0.961 -0.037 -0.112 0.038 0.333 0.564CE(18:2) 0.030 -0.050 0.110 0.458 0.704 0.066 -0.004 0.136 0.064 0.268 -0.004 -0.066 0.058 0.898 0.960 -0.043 -0.117 0.032 0.261 0.471AC(16:1) 0.025 -0.041 0.090 0.458 0.704 0.051 -0.008 0.110 0.091 0.310 -0.039 -0.083 0.005 0.085 0.329 -0.092 -0.153 -0.031 0.003 0.049TG(54:6) [NL-20:4] 0.030 -0.049 0.108 0.457 0.704 0.084 0.013 0.155 0.020 0.145 -0.014 -0.070 0.042 0.615 0.823 -0.081 -0.157 -0.006 0.034 0.172Cer(d18:1/26:0) 0.029 -0.048 0.106 0.463 0.710 -0.027 -0.096 0.041 0.433 0.633 0.031 -0.019 0.081 0.227 0.537 -0.016 -0.086 0.053 0.647 0.815PC(38:2) -0.033 -0.123 0.056 0.463 0.710 -0.017 -0.096 0.063 0.680 0.831 0.070 0.007 0.133 0.030 0.193 0.009 -0.075 0.094 0.828 0.909Cer(m18:1/24:0) -0.029 -0.108 0.049 0.466 0.713 -0.028 -0.098 0.041 0.421 0.622 0.014 -0.038 0.065 0.600 0.814 0.019 -0.053 0.090 0.607 0.789CE(20:3) -0.028 -0.105 0.048 0.468 0.714 0.034 -0.033 0.100 0.319 0.550 0.037 -0.015 0.089 0.165 0.457 -0.008 -0.077 0.061 0.825 0.909Cer(d19:1/22:0) 0.025 -0.043 0.094 0.470 0.715 0.056 -0.005 0.116 0.073 0.285 0.002 -0.044 0.048 0.932 0.969 -0.058 -0.122 0.005 0.071 0.250Cer(m18:0/22:0) -0.030 -0.114 0.053 0.476 0.721 -0.002 -0.075 0.070 0.948 0.977 0.018 -0.037 0.074 0.516 0.768 -0.031 -0.107 0.045 0.427 0.644PE(P-18:1/18:1) (a) -0.027 -0.101 0.047 0.475 0.721 -0.055 -0.121 0.010 0.099 0.315 0.128 0.080 0.176 0.000 0.000 0.098 0.030 0.165 0.005 0.059CE(24:6) -0.025 -0.093 0.043 0.477 0.721 0.006 -0.054 0.066 0.844 0.937 0.020 -0.024 0.065 0.370 0.672 0.018 -0.044 0.080 0.571 0.758PE(38:5) (a) 0.030 -0.052 0.111 0.478 0.722 0.081 0.008 0.154 0.030 0.184 -0.058 -0.114 -0.003 0.040 0.226 -0.061 -0.137 0.014 0.111 0.301TG(52:3) [NL-18:2] 0.028 -0.050 0.107 0.480 0.723 0.055 -0.019 0.129 0.146 0.380 -0.019 -0.079 0.041 0.540 0.779 -0.034 -0.111 0.044 0.394 0.617Cer(d18:1/16:0) 0.030 -0.054 0.115 0.484 0.727 0.016 -0.061 0.092 0.688 0.836 -0.032 -0.092 0.027 0.282 0.601 -0.101 -0.178 -0.023 0.011 0.089PE(P-16:0/22:4) -0.026 -0.099 0.047 0.484 0.727 0.086 0.021 0.151 0.010 0.100 -0.015 -0.065 0.034 0.545 0.779 -0.042 -0.110 0.026 0.229 0.441PE(18:0_20:3) (a) -0.031 -0.120 0.057 0.488 0.730 0.009 -0.071 0.090 0.820 0.922 0.006 -0.056 0.067 0.853 0.940 0.041 -0.043 0.125 0.336 0.567LPI(20:4) [sn1] -0.024 -0.091 0.044 0.493 0.737 0.047 -0.013 0.107 0.122 0.351 0.006 -0.040 0.052 0.789 0.912 -0.071 -0.134 -0.008 0.027 0.153Hex3Cer(d18:1/22:0) -0.029 -0.112 0.055 0.499 0.740 0.037 -0.035 0.110 0.312 0.545 -0.028 -0.083 0.027 0.323 0.635 -0.067 -0.141 0.008 0.081 0.269PC(P-16:0/16:0) -0.028 -0.109 0.053 0.498 0.740 0.003 -0.069 0.075 0.930 0.968 -0.046 -0.100 0.007 0.089 0.340 -0.027 -0.102 0.049 0.485 0.695PC(15:0_20:4) -0.026 -0.100 0.049 0.499 0.740 0.053 -0.012 0.119 0.109 0.331 -0.009 -0.058 0.040 0.720 0.887 -0.060 -0.129 0.008 0.086 0.271TG(50:1) [NL-14:0] -0.026 -0.101 0.049 0.497 0.740 0.027 -0.042 0.096 0.443 0.643 -0.050 -0.103 0.002 0.058 0.270 -0.058 -0.131 0.015 0.118 0.311Cer(m18:1/22:0) -0.028 -0.110 0.054 0.506 0.748 -0.027 -0.100 0.045 0.455 0.654 0.005 -0.048 0.059 0.842 0.932 0.006 -0.068 0.081 0.870 0.929PI(18:0_20:2) -0.026 -0.103 0.051 0.507 0.749 -0.036 -0.105 0.034 0.313 0.545 0.076 0.024 0.128 0.004 0.057 0.050 -0.023 0.122 0.181 0.386PC(18:1_18:1) 0.027 -0.053 0.107 0.508 0.750 0.006 -0.065 0.078 0.863 0.943 0.040 -0.017 0.096 0.168 0.458 -0.038 -0.112 0.036 0.315 0.538PC(31:0) (a) -0.023 -0.091 0.045 0.515 0.754 0.035 -0.026 0.097 0.260 0.493 -0.020 -0.066 0.026 0.391 0.685 -0.022 -0.085 0.042 0.501 0.701PI(39:6) -0.024 -0.095 0.048 0.515 0.754 -0.040 -0.104 0.023 0.212 0.456 0.006 -0.040 0.053 0.787 0.912 0.009 -0.056 0.074 0.788 0.886PI(38:5) (b) 0.024 -0.049 0.097 0.514 0.754 0.131 0.068 0.194 0.000 0.016 -0.065 -0.120 -0.009 0.023 0.166 -0.121 -0.186 -0.055 0.000 0.017TG(54:4) [NL-20:3] -0.027 -0.107 0.054 0.515 0.754 0.070 -0.003 0.142 0.060 0.260 0.016 -0.042 0.073 0.593 0.811 -0.025 -0.102 0.053 0.530 0.727PE(P-18:1/22:5) (b) -0.024 -0.095 0.048 0.517 0.755 0.057 -0.006 0.120 0.075 0.286 0.027 -0.024 0.077 0.302 0.620 -0.054 -0.119 0.012 0.109 0.299AC(16:1)-OH -0.021 -0.086 0.043 0.520 0.758 0.023 -0.035 0.081 0.439 0.639 -0.019 -0.063 0.025 0.401 0.691 -0.091 -0.151 -0.031 0.003 0.049Cer(m18:0/24:0) -0.026 -0.106 0.054 0.524 0.760 -0.011 -0.080 0.058 0.755 0.880 0.023 -0.030 0.076 0.390 0.684 -0.032 -0.104 0.041 0.392 0.615Cer(d18:1/23:0) 0.027 -0.056 0.110 0.527 0.760 0.043 -0.030 0.117 0.246 0.491 -0.006 -0.062 0.051 0.849 0.937 -0.057 -0.133 0.019 0.143 0.349SHexCer(d18:1/24:1) 0.027 -0.057 0.112 0.525 0.760 -0.031 -0.100 0.038 0.384 0.592 -0.009 -0.059 0.042 0.733 0.887 -0.028 -0.101 0.044 0.444 0.660PE(16:0_20:5) -0.025 -0.101 0.051 0.523 0.760 -0.025 -0.094 0.043 0.463 0.661 -0.032 -0.083 0.019 0.224 0.534 -0.016 -0.087 0.055 0.665 0.823PI(38:6) -0.024 -0.097 0.049 0.526 0.760 -0.010 -0.075 0.055 0.764 0.885 -0.002 -0.050 0.046 0.938 0.973 -0.041 -0.108 0.026 0.232 0.444SM(d17:1/14:0) 0.025 -0.054 0.105 0.529 0.761 0.065 -0.005 0.135 0.069 0.279 0.003 -0.049 0.055 0.909 0.962 -0.017 -0.089 0.056 0.656 0.816DG(16:0_22:5) -0.028 -0.116 0.060 0.530 0.761 -0.014 -0.091 0.063 0.725 0.864 -0.060 -0.117 -0.003 0.041 0.227 -0.046 -0.126 0.035 0.264 0.473PC(17:0_18:2) 0.026 -0.055 0.106 0.534 0.766 0.028 -0.044 0.100 0.448 0.649 0.025 -0.031 0.081 0.384 0.678 -0.031 -0.106 0.045 0.424 0.642PE(18:0_22:5) (n3) -0.028 -0.118 0.061 0.535 0.766 0.036 -0.044 0.117 0.373 0.584 -0.075 -0.135 -0.014 0.016 0.137 -0.018 -0.101 0.066 0.676 0.825AC(12:0) -0.020 -0.085 0.045 0.538 0.769 0.042 -0.016 0.101 0.152 0.385 -0.011 -0.054 0.033 0.628 0.829 -0.062 -0.123 -0.002 0.044 0.194PE(16:0_18:3) (b) 0.024 -0.053 0.101 0.540 0.771 0.101 0.032 0.170 0.004 0.065 -0.054 -0.106 -0.001 0.045 0.243 -0.054 -0.126 0.018 0.140 0.344CE(22:6) -0.029 -0.121 0.064 0.542 0.772 -0.101 -0.179 -0.023 0.012 0.107 0.059 0.001 0.116 0.045 0.243 0.034 -0.047 0.115 0.407 0.632SM(41:1) (a) -0.021 -0.091 0.048 0.546 0.774 0.018 -0.043 0.079 0.562 0.746 0.044 -0.002 0.090 0.058 0.270 0.021 -0.044 0.085 0.531 0.727PI(16:0_20:3) (a) 0.023 -0.052 0.099 0.546 0.774 0.109 0.042 0.176 0.001 0.037 -0.015 -0.070 0.039 0.584 0.810 -0.056 -0.125 0.014 0.116 0.309 ### Page 17 FA(20:4) 0.020 -0.046 0.086 0.547 0.774 0.027 -0.032 0.085 0.374 0.584 -0.024 -0.069 0.021 0.288 0.606 -0.054 -0.114 0.007 0.081 0.268Ubiquinone -0.020 -0.087 0.046 0.548 0.774 0.021 -0.038 0.080 0.490 0.684 -0.005 -0.051 0.041 0.845 0.934 -0.002 -0.063 0.060 0.960 0.977SM(d16:1/24:1) 0.024 -0.056 0.104 0.551 0.775 -0.014 -0.085 0.056 0.688 0.836 0.014 -0.039 0.067 0.603 0.815 -0.077 -0.151 -0.004 0.039 0.183HexCer(d18:1/18:0) 0.020 -0.046 0.087 0.554 0.775 0.033 -0.028 0.093 0.289 0.525 -0.036 -0.082 0.009 0.121 0.391 -0.037 -0.099 0.026 0.252 0.461PA(36:2) 0.022 -0.049 0.093 0.551 0.775 0.001 -0.061 0.063 0.974 0.982 0.027 -0.018 0.073 0.244 0.560 0.045 -0.020 0.109 0.173 0.378PC(14:0_16:0) 0.024 -0.056 0.105 0.554 0.775 0.055 -0.018 0.127 0.139 0.372 -0.060 -0.115 -0.005 0.033 0.209 -0.097 -0.172 -0.023 0.011 0.089PC(40:8) 0.026 -0.061 0.114 0.555 0.775 0.014 -0.060 0.088 0.707 0.851 0.036 -0.022 0.094 0.225 0.534 -0.054 -0.132 0.023 0.167 0.372TG(O-50:2) [NL-18:1] -0.020 -0.085 0.046 0.553 0.775 -0.039 -0.097 0.019 0.191 0.428 0.030 -0.014 0.074 0.185 0.483 -0.041 -0.101 0.020 0.188 0.394Cer(d17:1/16:0) 0.020 -0.048 0.089 0.563 0.784 0.035 -0.026 0.096 0.257 0.492 0.027 -0.018 0.073 0.236 0.549 0.007 -0.056 0.070 0.829 0.909Cer(d18:1/18:0) -0.021 -0.092 0.050 0.563 0.784 0.021 -0.043 0.085 0.529 0.719 -0.036 -0.084 0.012 0.147 0.429 -0.076 -0.142 -0.010 0.024 0.144PA(36:4) 0.020 -0.049 0.090 0.567 0.785 -0.050 -0.110 0.010 0.105 0.328 0.030 -0.015 0.074 0.192 0.494 0.064 0.002 0.127 0.044 0.194PC(15:0_22:6) -0.021 -0.095 0.052 0.565 0.785 -0.073 -0.138 -0.008 0.028 0.182 0.038 -0.011 0.087 0.129 0.407 -0.003 -0.070 0.065 0.940 0.969FA(18:0) 0.019 -0.046 0.084 0.567 0.785 -0.023 -0.081 0.035 0.441 0.641 -0.002 -0.045 0.041 0.927 0.968 -0.051 -0.111 0.008 0.091 0.278Cer(d19:1/23:0) 0.020 -0.049 0.088 0.575 0.788 0.038 -0.022 0.099 0.217 0.457 0.010 -0.035 0.056 0.651 0.848 -0.037 -0.099 0.026 0.252 0.461PC(32:1) 0.023 -0.058 0.105 0.574 0.788 0.097 0.025 0.169 0.008 0.096 -0.084 -0.139 -0.029 0.003 0.045 -0.117 -0.193 -0.042 0.002 0.041PC(15-MHDA_18:1) 0.021 -0.051 0.092 0.575 0.788 0.039 -0.025 0.103 0.229 0.475 -0.011 -0.060 0.038 0.658 0.849 -0.064 -0.130 0.002 0.059 0.227PC(P-16:0/18:2) 0.027 -0.066 0.119 0.572 0.788 0.005 -0.074 0.084 0.905 0.960 0.051 -0.009 0.112 0.094 0.346 0.000 -0.083 0.082 0.995 0.997PC(15:0_20:3) 0.022 -0.054 0.098 0.575 0.788 0.074 0.006 0.142 0.034 0.194 0.018 -0.035 0.070 0.511 0.765 -0.006 -0.076 0.065 0.878 0.934TG(48:3) [NL-18:3] 0.025 -0.062 0.112 0.575 0.788 0.064 -0.016 0.144 0.117 0.344 -0.039 -0.099 0.021 0.205 0.510 -0.061 -0.145 0.022 0.151 0.358Cer(d18:1/14:0) 0.020 -0.052 0.092 0.585 0.789 0.041 -0.023 0.106 0.206 0.450 -0.011 -0.059 0.037 0.665 0.854 -0.045 -0.111 0.021 0.185 0.390Cer(d18:1/24:0) 0.023 -0.059 0.105 0.580 0.789 0.009 -0.063 0.081 0.807 0.914 0.031 -0.025 0.086 0.277 0.596 -0.009 -0.083 0.066 0.822 0.909PC(33:2) 0.022 -0.055 0.099 0.584 0.789 0.070 0.001 0.139 0.046 0.225 -0.009 -0.062 0.043 0.725 0.887 -0.036 -0.108 0.036 0.325 0.551PE(16:0_20:3) 0.022 -0.056 0.100 0.581 0.789 0.084 0.014 0.154 0.019 0.141 -0.048 -0.104 0.008 0.095 0.346 -0.046 -0.118 0.027 0.219 0.426PI(15-MHDA_20:4) & PI(17:0_20:4) 0.021 -0.054 0.097 0.578 0.789 0.095 0.028 0.162 0.006 0.077 -0.008 -0.060 0.043 0.746 0.894 -0.065 -0.136 0.005 0.069 0.249dxCA 0.018 -0.047 0.083 0.581 0.789 0.061 0.004 0.119 0.037 0.198 -0.021 -0.064 0.022 0.339 0.648 -0.051 -0.110 0.009 0.097 0.281DG(16:1_18:1) 0.031 -0.079 0.140 0.582 0.789 0.062 -0.032 0.155 0.197 0.435 -0.088 -0.162 -0.015 0.018 0.148 -0.164 -0.260 -0.067 0.001 0.028DG(18:1_20:3) -0.023 -0.106 0.060 0.585 0.789 0.016 -0.058 0.089 0.677 0.830 0.018 -0.038 0.074 0.538 0.779 -0.059 -0.136 0.018 0.135 0.335CE(22:6) [+OH] 0.019 -0.050 0.088 0.582 0.789 -0.080 -0.141 -0.019 0.010 0.100 -0.002 -0.051 0.047 0.936 0.972 -0.067 -0.130 -0.005 0.036 0.177FA(18:2) -0.018 -0.085 0.048 0.588 0.791 -0.017 -0.076 0.043 0.582 0.765 -0.001 -0.045 0.043 0.962 0.983 -0.045 -0.106 0.017 0.156 0.359methyl-CE(18:1) -0.020 -0.094 0.053 0.592 0.793 -0.030 -0.097 0.036 0.370 0.583 0.063 0.014 0.112 0.012 0.114 0.044 -0.024 0.112 0.208 0.415TG(54:3) [NL-18:2] 0.021 -0.055 0.096 0.591 0.793 0.041 -0.029 0.112 0.248 0.492 -0.013 -0.069 0.043 0.653 0.848 -0.016 -0.090 0.058 0.674 0.824PC(P-18:0/18:2) 0.023 -0.062 0.109 0.593 0.793 0.029 -0.044 0.103 0.432 0.633 0.036 -0.021 0.093 0.218 0.530 -0.028 -0.105 0.049 0.473 0.686SM(38:3) (a) 0.019 -0.052 0.091 0.595 0.795 0.058 -0.006 0.123 0.074 0.286 -0.023 -0.072 0.025 0.345 0.653 -0.075 -0.142 -0.009 0.027 0.152PE(20:0_20:4) 0.020 -0.054 0.094 0.597 0.796 0.020 -0.046 0.087 0.553 0.742 -0.021 -0.070 0.029 0.414 0.705 0.029 -0.040 0.098 0.415 0.640PE(16:0_18:3) (a) 0.021 -0.057 0.098 0.599 0.797 0.060 -0.010 0.130 0.091 0.310 -0.041 -0.094 0.013 0.135 0.417 -0.062 -0.134 0.011 0.095 0.278HexCer(d18:2/18:0) 0.018 -0.051 0.088 0.605 0.803 0.010 -0.053 0.072 0.765 0.885 -0.020 -0.066 0.027 0.402 0.691 -0.047 -0.112 0.017 0.149 0.357TG(51:2) [NL-15:0] 0.021 -0.059 0.101 0.605 0.803 0.037 -0.037 0.111 0.330 0.564 -0.016 -0.073 0.042 0.596 0.811 -0.025 -0.102 0.052 0.529 0.727SM(37:1) -0.019 -0.092 0.054 0.609 0.804 0.037 -0.027 0.102 0.258 0.493 0.033 -0.015 0.082 0.179 0.479 0.021 -0.047 0.089 0.539 0.729Cer(d18:2/18:0) -0.019 -0.093 0.055 0.608 0.804 0.006 -0.060 0.071 0.867 0.943 -0.017 -0.067 0.032 0.492 0.747 -0.018 -0.086 0.051 0.613 0.796CE(14:0) 0.018 -0.051 0.087 0.611 0.805 0.028 -0.033 0.090 0.370 0.583 -0.029 -0.075 0.016 0.209 0.517 -0.034 -0.097 0.030 0.299 0.519PE(36:0) -0.017 -0.081 0.048 0.614 0.808 0.018 -0.039 0.075 0.537 0.729 -0.010 -0.052 0.033 0.655 0.849 -0.011 -0.071 0.048 0.705 0.840PC(16:0_22:6) -0.019 -0.093 0.055 0.617 0.809 -0.084 -0.149 -0.020 0.011 0.106 0.040 -0.010 0.089 0.116 0.388 -0.007 -0.075 0.061 0.837 0.912LPE(P-16:0) 0.017 -0.049 0.082 0.619 0.809 -0.017 -0.075 0.041 0.574 0.757 0.030 -0.014 0.074 0.177 0.476 0.025 -0.035 0.085 0.419 0.640DG(16:0_16:1) -0.026 -0.127 0.076 0.619 0.809 0.070 -0.018 0.158 0.120 0.346 -0.078 -0.147 -0.009 0.026 0.181 -0.144 -0.236 -0.051 0.002 0.041TG(48:2) [NL-16:1] 0.021 -0.063 0.106 0.617 0.809 0.092 0.016 0.168 0.018 0.140 -0.074 -0.133 -0.015 0.014 0.125 -0.114 -0.194 -0.035 0.005 0.061PC(P-17:0/20:4) (b) -0.018 -0.088 0.053 0.621 0.809 0.015 -0.047 0.077 0.631 0.790 0.053 0.006 0.099 0.027 0.185 -0.027 -0.091 0.037 0.408 0.632PE(18:1_18:1) -0.018 -0.089 0.053 0.621 0.809 -0.014 -0.079 0.051 0.681 0.831 0.049 0.001 0.097 0.047 0.243 0.046 -0.022 0.113 0.184 0.389Cer(d16:1/18:0) -0.018 -0.092 0.055 0.623 0.810 0.024 -0.040 0.089 0.460 0.659 -0.003 -0.051 0.046 0.918 0.964 -0.011 -0.079 0.056 0.740 0.863SM(d18:2/17:0) -0.021 -0.105 0.063 0.624 0.810 0.043 -0.030 0.116 0.251 0.492 0.029 -0.028 0.086 0.320 0.635 -0.069 -0.145 0.008 0.077 0.264PC(20:0_20:4) 0.018 -0.055 0.091 0.626 0.811 0.044 -0.021 0.109 0.186 0.426 0.007 -0.042 0.055 0.789 0.912 -0.011 -0.079 0.058 0.762 0.874PE(P-18:0/18:3) -0.017 -0.088 0.053 0.628 0.812 0.018 -0.044 0.081 0.563 0.746 0.039 -0.008 0.086 0.102 0.364 0.024 -0.040 0.089 0.465 0.678AC(22:5) 0.016 -0.050 0.083 0.630 0.813 -0.005 -0.064 0.055 0.878 0.947 0.005 -0.039 0.049 0.812 0.925 0.009 -0.052 0.070 0.771 0.875PE(P-20:0/20:4) -0.017 -0.087 0.053 0.634 0.814 -0.031 -0.093 0.031 0.332 0.565 0.019 -0.027 0.065 0.427 0.713 -0.048 -0.112 0.016 0.143 0.349AC(18:0) 0.017 -0.052 0.085 0.634 0.814 0.034 -0.028 0.096 0.285 0.520 -0.032 -0.080 0.015 0.183 0.482 -0.098 -0.162 -0.033 0.003 0.049TG(52:2) [NL-16:0] -0.019 -0.099 0.060 0.633 0.814 0.051 -0.024 0.126 0.184 0.425 0.010 -0.051 0.071 0.757 0.899 -0.048 -0.128 0.031 0.234 0.444SM(d18:0/16:0) -0.019 -0.097 0.059 0.636 0.816 -0.048 -0.118 0.022 0.181 0.425 0.086 0.033 0.139 0.001 0.027 0.074 0.002 0.147 0.045 0.194SM(d18:2/14:0) 0.024 -0.076 0.124 0.644 0.824 0.080 -0.007 0.167 0.070 0.282 -0.002 -0.066 0.062 0.952 0.979 -0.036 -0.126 0.054 0.428 0.644PE(18:0_18:2) -0.020 -0.106 0.066 0.651 0.827 -0.001 -0.081 0.078 0.972 0.982 -0.009 -0.069 0.050 0.757 0.899 0.014 -0.068 0.096 0.735 0.860PE(P-18:1/22:4) -0.016 -0.088 0.055 0.653 0.827 0.126 0.063 0.188 0.000 0.016 -0.008 -0.071 0.055 0.799 0.916 -0.104 -0.170 -0.039 0.002 0.041PE(O-16:0/18:2) -0.016 -0.086 0.054 0.654 0.827 -0.006 -0.069 0.057 0.851 0.938 0.026 -0.020 0.073 0.269 0.588 -0.001 -0.066 0.063 0.965 0.978FA(20:5) -0.016 -0.086 0.054 0.653 0.827 -0.046 -0.108 0.016 0.146 0.380 0.011 -0.035 0.057 0.627 0.829 0.015 -0.049 0.078 0.655 0.816AC(16:0) -0.015 -0.082 0.051 0.651 0.827 0.022 -0.038 0.082 0.466 0.662 -0.037 -0.081 0.008 0.106 0.368 -0.069 -0.130 -0.007 0.028 0.154methyl-DE(18:2) -0.018 -0.098 0.061 0.651 0.827 -0.002 -0.074 0.070 0.963 0.980 0.069 0.016 0.122 0.011 0.110 0.086 0.013 0.160 0.022 0.134TG(54:5) [NL-20:4] -0.018 -0.095 0.059 0.654 0.827 0.033 -0.037 0.102 0.354 0.576 0.014 -0.039 0.067 0.609 0.819 -0.017 -0.091 0.057 0.659 0.819SM(37:2) -0.018 -0.098 0.061 0.656 0.828 0.008 -0.060 0.076 0.820 0.922 0.067 0.017 0.117 0.009 0.100 0.047 -0.023 0.117 0.188 0.394LPI(20:4) [sn2] -0.016 -0.085 0.054 0.658 0.830 0.072 0.013 0.132 0.018 0.141 -0.014 -0.063 0.035 0.571 0.801 -0.099 -0.162 -0.035 0.002 0.041PC(40:7) (a) 0.020 -0.070 0.110 0.660 0.830 0.071 -0.005 0.148 0.067 0.272 0.044 -0.017 0.105 0.160 0.454 -0.020 -0.102 0.062 0.636 0.809PC(15-MHDA_20:4) -0.016 -0.089 0.056 0.660 0.830 0.047 -0.017 0.111 0.150 0.384 0.009 -0.040 0.058 0.725 0.887 -0.070 -0.137 -0.003 0.041 0.185PE(16:0_18:2) 0.018 -0.062 0.097 0.662 0.831 0.057 -0.017 0.130 0.129 0.359 -0.047 -0.102 0.008 0.094 0.346 -0.033 -0.108 0.043 0.399 0.624PE(16:0_20:4) -0.018 -0.098 0.063 0.669 0.835 0.041 -0.032 0.115 0.271 0.506 -0.052 -0.108 0.003 0.063 0.284 -0.061 -0.137 0.014 0.112 0.302PI(18:0_20:4) 0.018 -0.063 0.098 0.668 0.835 0.062 -0.009 0.134 0.088 0.310 -0.027 -0.083 0.030 0.354 0.666 -0.118 -0.194 -0.042 0.002 0.041PG(34:1) 0.020 -0.072 0.112 0.669 0.835 -0.004 -0.085 0.078 0.932 0.969 -0.055 -0.117 0.008 0.088 0.338 -0.110 -0.195 -0.025 0.011 0.090FA(20:3) -0.015 -0.083 0.053 0.673 0.839 0.009 -0.051 0.069 0.778 0.897 0.008 -0.037 0.053 0.725 0.887 -0.051 -0.113 0.010 0.103 0.287AC(18:1)-OH -0.014 -0.079 0.051 0.679 0.845 0.007 -0.052 0.066 0.809 0.916 -0.019 -0.063 0.025 0.399 0.691 -0.069 -0.130 -0.008 0.028 0.153Cer(d19:1/24:0) 0.014 -0.055 0.083 0.681 0.846 0.019 -0.042 0.080 0.541 0.730 0.022 -0.023 0.067 0.336 0.646 -0.006 -0.069 0.058 0.860 0.923SM(d17:1/16:0) -0.018 -0.103 0.067 0.686 0.848 0.039 -0.036 0.113 0.313 0.545 0.030 -0.027 0.087 0.308 0.623 -0.054 -0.133 0.025 0.181 0.386PC(P-16:0/18:0) 0.019 -0.073 0.110 0.688 0.848 0.032 -0.046 0.111 0.420 0.622 0.004 -0.057 0.065 0.898 0.960 -0.058 -0.141 0.025 0.169 0.372PC(P-36:3) 0.017 -0.065 0.098 0.687 0.848 0.044 -0.025 0.114 0.210 0.454 0.060 0.005 0.115 0.033 0.206 -0.022 -0.095 0.050 0.549 0.739PE(17:0_18:2) 0.016 -0.062 0.093 0.688 0.848 0.062 -0.010 0.134 0.092 0.310 -0.009 -0.064 0.045 0.733 0.887 -0.036 -0.110 0.038 0.338 0.568TG(56:8) [NL-20:4] 0.014 -0.056 0.085 0.686 0.848 0.047 -0.016 0.110 0.140 0.374 -0.006 -0.054 0.043 0.816 0.925 -0.047 -0.113 0.019 0.162 0.366PS(40:5) -0.013 -0.078 0.052 0.691 0.850 -0.015 -0.072 0.043 0.616 0.783 0.006 -0.036 0.049 0.769 0.902 0.006 -0.054 0.065 0.844 0.916PE(15-MHDA_18:1) -0.015 -0.088 0.059 0.699 0.858 0.033 -0.032 0.099 0.319 0.550 -0.014 -0.063 0.035 0.572 0.801 -0.033 -0.101 0.035 0.339 0.569CE(20:2) 0.017 -0.072 0.107 0.705 0.864 0.013 -0.065 0.091 0.745 0.873 0.035 -0.026 0.097 0.254 0.572 -0.047 -0.131 0.037 0.270 0.479SM(34:3) -0.016 -0.102 0.070 0.708 0.865 0.085 0.017 0.153 0.014 0.116 -0.010 -0.074 0.055 0.772 0.902 -0.118 -0.188 -0.048 0.001 0.028CE(20:4) [+OH] 0.014 -0.057 0.085 0.708 0.865 0.012 -0.051 0.076 0.705 0.851 -0.009 -0.057 0.040 0.728 0.887 -0.111 -0.176 -0.046 0.001 0.027SM(d18:2/24:0) -0.017 -0.108 0.074 0.709 0.865 0.002 -0.076 0.080 0.958 0.980 0.051 -0.008 0.110 0.091 0.342 0.033 -0.049 0.115 0.427 0.644SM(38:3) (b) -0.013 -0.082 0.056 0.712 0.867 0.091 0.031 0.151 0.003 0.055 0.013 -0.038 0.064 0.614 0.823 -0.077 -0.140 -0.015 0.015 0.110PE(P-18:1/18:3) 0.013 -0.057 0.083 0.718 0.870 0.008 -0.054 0.070 0.795 0.908 0.079 0.032 0.126 0.001 0.021 0.056 -0.009 0.121 0.091 0.278AC(14:1) -0.012 -0.077 0.053 0.717 0.870 0.027 -0.032 0.085 0.369 0.583 -0.020 -0.064 0.024 0.374 0.676 -0.069 -0.130 -0.008 0.028 0.153TG(51:2) [NL-17:0] 0.016 -0.072 0.104 0.718 0.870 0.084 0.002 0.165 0.044 0.219 -0.055 -0.118 0.007 0.084 0.329 -0.112 -0.198 -0.027 0.010 0.089PC(16:0_18:1) 0.015 -0.070 0.100 0.725 0.878 0.019 -0.056 0.093 0.623 0.783 -0.033 -0.092 0.026 0.270 0.588 -0.046 -0.125 0.033 0.255 0.464SM(d18:2/18:1) -0.014 -0.093 0.065 0.731 0.882 0.080 0.013 0.146 0.019 0.141 -0.012 -0.072 0.049 0.707 0.875 -0.120 -0.189 -0.052 0.001 0.025PI(15-MHDA_18:1) & PI(17:0_18:1) -0.012 -0.078 0.055 0.733 0.882 0.028 -0.032 0.089 0.362 0.580 0.024 -0.023 0.071 0.310 0.626 -0.003 -0.066 0.060 0.922 0.958LPI(18:0) [sn1] -0.012 -0.082 0.058 0.734 0.882 0.004 -0.057 0.064 0.908 0.961 0.005 -0.040 0.050 0.825 0.925 0.040 -0.023 0.103 0.213 0.422TG(50:4) [NL-20:4] -0.014 -0.095 0.067 0.732 0.882 0.051 -0.023 0.124 0.177 0.420 -0.029 -0.084 0.027 0.313 0.628 -0.060 -0.138 0.018 0.130 0.332Cer(d17:1/20:0) 0.011 -0.059 0.082 0.748 0.883 0.053 -0.010 0.115 0.098 0.312 -0.005 -0.052 0.042 0.839 0.932 -0.014 -0.079 0.051 0.669 0.823Cer(d17:1/23:0) 0.012 -0.060 0.085 0.737 0.883 0.049 -0.015 0.114 0.134 0.366 0.004 -0.044 0.052 0.879 0.953 -0.019 -0.086 0.048 0.578 0.760Cer(d18:1/20:0) 0.012 -0.061 0.085 0.746 0.883 0.045 -0.021 0.111 0.185 0.425 -0.026 -0.077 0.024 0.302 0.620 -0.073 -0.141 -0.004 0.038 0.182Cer(d19:1/20:0) 0.011 -0.054 0.077 0.737 0.883 0.050 -0.009 0.108 0.096 0.312 -0.018 -0.062 0.025 0.408 0.697 -0.069 -0.129 -0.009 0.025 0.147SM(d18:1/17:0) & SM(d17:1/18:0) -0.011 -0.079 0.057 0.748 0.883 -0.017 -0.077 0.043 0.584 0.766 0.032 -0.013 0.076 0.168 0.458 0.010 -0.053 0.073 0.760 0.874PC(O-36:0) 0.013 -0.063 0.088 0.741 0.883 0.078 0.011 0.145 0.023 0.163 -0.032 -0.084 0.019 0.222 0.534 -0.036 -0.107 0.035 0.314 0.538PC(17:0_20:4) -0.012 -0.084 0.060 0.741 0.883 0.034 -0.030 0.097 0.297 0.528 0.012 -0.036 0.061 0.618 0.825 -0.077 -0.143 -0.010 0.024 0.145PC(P-15:0/20:4) (a) -0.011 -0.077 0.055 0.741 0.883 0.025 -0.034 0.083 0.409 0.617 0.044 0.001 0.088 0.047 0.243 -0.002 -0.062 0.059 0.961 0.977PE(15-MHDA_20:4) 0.012 -0.062 0.087 0.744 0.883 0.046 -0.019 0.112 0.167 0.400 -0.024 -0.073 0.025 0.333 0.646 -0.040 -0.108 0.028 0.253 0.461PE(18:1_22:6) (a) -0.013 -0.090 0.065 0.748 0.883 -0.053 -0.123 0.017 0.140 0.374 0.020 -0.032 0.073 0.452 0.728 0.016 -0.056 0.088 0.667 0.823PE(P-20:0/18:2) 0.012 -0.062 0.086 0.748 0.883 0.007 -0.059 0.074 0.830 0.928 0.017 -0.032 0.065 0.498 0.753 0.020 -0.048 0.088 0.560 0.749CE(18:1) -0.015 -0.106 0.075 0.743 0.883 -0.021 -0.100 0.058 0.608 0.778 0.040 -0.026 0.106 0.237 0.550 -0.110 -0.193 -0.027 0.010 0.089Cer1P(d18:1/16:0) 0.014 -0.072 0.100 0.752 0.884 0.037 -0.039 0.113 0.343 0.572 0.003 -0.054 0.059 0.928 0.968 -0.039 -0.116 0.038 0.324 0.551CE(17:0) 0.013 -0.067 0.093 0.752 0.884 0.006 -0.064 0.076 0.866 0.943 0.008 -0.045 0.060 0.772 0.902 -0.026 -0.100 0.047 0.480 0.689Sph(d18:2) 0.010 -0.053 0.073 0.759 0.890 -0.053 -0.110 0.003 0.065 0.269 0.019 -0.029 0.068 0.433 0.715 0.043 -0.015 0.102 0.148 0.357CE(17:1) -0.012 -0.087 0.064 0.759 0.890 0.042 -0.026 0.109 0.227 0.473 -0.015 -0.066 0.036 0.565 0.797 -0.057 -0.128 0.013 0.110 0.301Hex3Cer(d18:1/24:1) 0.013 -0.074 0.101 0.765 0.894 -0.037 -0.114 0.039 0.338 0.571 0.006 -0.051 0.063 0.826 0.925 -0.090 -0.170 -0.011 0.026 0.152PC(16:0_20:4) -0.011 -0.082 0.060 0.764 0.894 0.039 -0.023 0.101 0.222 0.465 -0.036 -0.084 0.011 0.136 0.418 -0.067 -0.133 -0.001 0.048 0.200PC(17:0_18:1) 0.012 -0.068 0.092 0.770 0.894 0.012 -0.059 0.083 0.748 0.875 0.022 -0.034 0.078 0.444 0.723 -0.057 -0.131 0.017 0.134 0.334PC(P-38:5) (a) -0.014 -0.104 0.077 0.769 0.894 0.038 -0.038 0.114 0.332 0.565 0.054 -0.006 0.115 0.079 0.320 -0.067 -0.145 0.011 0.094 0.278PG(36:2) 0.013 -0.075 0.101 0.770 0.894 -0.069 -0.148 0.011 0.090 0.310 -0.054 -0.112 0.005 0.074 0.308 -0.011 -0.091 0.070 0.796 0.891TG(56:8) [NL-20:5] -0.010 -0.079 0.058 0.769 0.894 -0.026 -0.088 0.036 0.413 0.617 0.005 -0.041 0.051 0.817 0.925 0.006 -0.058 0.071 0.846 0.916TG(54:7) [NL-20:5] -0.011 -0.087 0.065 0.776 0.900 -0.019 -0.087 0.050 0.594 0.775 -0.024 -0.075 0.027 0.357 0.667 -0.031 -0.102 0.041 0.400 0.625Hex3Cer(d18:1/24:0) -0.012 -0.099 0.075 0.782 0.906 -0.007 -0.083 0.069 0.858 0.940 -0.009 -0.065 0.047 0.754 0.899 -0.066 -0.143 0.011 0.092 0.278PI(36:2) 0.010 -0.066 0.087 0.789 0.912 0.028 -0.042 0.098 0.430 0.633 0.006 -0.048 0.059 0.829 0.927 -0.048 -0.120 0.024 0.189 0.394TG(50:2) [NL-18:2] -0.010 -0.088 0.067 0.794 0.916 0.034 -0.039 0.107 0.362 0.580 -0.036 -0.093 0.020 0.204 0.509 -0.032 -0.110 0.046 0.418 0.640FA(18:3) -0.009 -0.076 0.058 0.799 0.921 -0.001 -0.061 0.059 0.980 0.985 0.003 -0.042 0.048 0.895 0.959 -0.056 -0.118 0.006 0.075 0.259PI(16:0_20:4) -0.010 -0.089 0.069 0.809 0.931 0.100 0.030 0.171 0.005 0.077 -0.023 -0.076 0.030 0.401 0.691 -0.075 -0.150 -0.001 0.047 0.200DG(18:1_18:1) -0.014 -0.128 0.100 0.812 0.933 -0.080 -0.179 0.020 0.118 0.346 0.006 -0.069 0.082 0.869 0.949 -0.052 -0.153 0.050 0.319 0.544DG(16:0_18:2) 0.013 -0.096 0.122 0.817 0.937 0.008 -0.086 0.102 0.866 0.943 -0.055 -0.129 0.018 0.141 0.424 -0.083 -0.179 0.014 0.095 0.278PC(P-16:0/14:0) 0.009 -0.070 0.088 0.818 0.937 0.006 -0.064 0.075 0.872 0.944 -0.053 -0.105 -0.002 0.041 0.229 0.001 -0.071 0.073 0.982 0.989PA(36:1) -0.008 -0.076 0.060 0.821 0.939 -0.001 -0.060 0.058 0.974 0.982 0.028 -0.015 0.071 0.203 0.509 0.038 -0.023 0.098 0.221 0.427SM(43:2) (b) -0.008 -0.082 0.065 0.824 0.940 -0.028 -0.093 0.037 0.399 0.608 0.052 0.004 0.101 0.034 0.210 -0.027 -0.096 0.041 0.430 0.646PC(15-MHDA_22:6) 0.008 -0.063 0.079 0.825 0.940 -0.048 -0.111 0.014 0.130 0.360 0.033 -0.013 0.080 0.162 0.454 -0.014 -0.079 0.051 0.672 0.824AC(26:1) -0.008 -0.076 0.061 0.827 0.941 -0.014 -0.077 0.048 0.648 0.805 0.028 -0.019 0.075 0.243 0.558 -0.003 -0.067 0.062 0.936 0.967TG(53:2) [NL-18:1] -0.010 -0.102 0.082 0.827 0.941 -0.002 -0.086 0.081 0.960 0.980 0.020 -0.044 0.084 0.538 0.779 -0.063 -0.150 0.025 0.159 0.363Cer(d19:1/16:0) -0.007 -0.074 0.060 0.831 0.942 0.004 -0.056 0.064 0.903 0.960 -0.008 -0.054 0.038 0.728 0.887 -0.074 -0.136 -0.013 0.018 0.124CE(22:4) 0.009 -0.071 0.089 0.832 0.942 0.107 0.037 0.177 0.003 0.055 -0.062 -0.118 -0.006 0.029 0.192 -0.137 -0.211 -0.064 0.000 0.017 ### Page 18 PA(40:6) 0.007 -0.060 0.074 0.841 0.947 0.023 -0.035 0.081 0.434 0.633 -0.009 -0.052 0.034 0.669 0.855 -0.004 -0.064 0.057 0.908 0.948PC(P-18:0/22:5) -0.009 -0.093 0.075 0.837 0.947 0.013 -0.060 0.086 0.727 0.864 0.017 -0.038 0.073 0.544 0.779 -0.046 -0.121 0.028 0.225 0.435AC(24:1) 0.007 -0.060 0.074 0.840 0.947 -0.015 -0.076 0.046 0.622 0.783 0.011 -0.037 0.058 0.666 0.854 -0.060 -0.124 0.003 0.062 0.234CE(20:4) 0.011 -0.096 0.118 0.839 0.947 0.077 -0.018 0.172 0.110 0.333 -0.014 -0.084 0.055 0.683 0.864 -0.115 -0.212 -0.018 0.020 0.128GM3(d18:1/20:0) 0.006 -0.059 0.071 0.845 0.947 0.025 -0.034 0.084 0.411 0.617 -0.003 -0.052 0.046 0.903 0.961 -0.051 -0.112 0.010 0.101 0.284PC(33:0) (a) 0.007 -0.067 0.081 0.847 0.947 0.051 -0.015 0.117 0.128 0.358 -0.020 -0.070 0.031 0.443 0.722 -0.059 -0.128 0.009 0.089 0.275SM(d19:1/24:1) 0.007 -0.060 0.073 0.848 0.947 -0.006 -0.065 0.054 0.851 0.938 0.042 -0.002 0.085 0.062 0.283 -0.023 -0.084 0.039 0.473 0.686PC(44:12) -0.007 -0.076 0.063 0.849 0.947 -0.068 -0.131 -0.006 0.032 0.188 0.031 -0.016 0.077 0.193 0.495 -0.029 -0.093 0.035 0.377 0.604PI(16:0_20:3) (b) 0.008 -0.071 0.086 0.848 0.947 0.081 0.012 0.151 0.022 0.152 -0.041 -0.095 0.013 0.133 0.413 -0.080 -0.153 -0.007 0.031 0.162TG(51:2) [NL-17:1] 0.009 -0.078 0.095 0.845 0.947 0.082 0.004 0.160 0.040 0.210 -0.025 -0.086 0.036 0.421 0.709 -0.106 -0.189 -0.024 0.012 0.090PC(33:1) 0.008 -0.073 0.089 0.852 0.949 0.070 -0.002 0.142 0.058 0.254 -0.032 -0.088 0.023 0.257 0.574 -0.075 -0.150 0.001 0.052 0.207PC(18:0_18:2) 0.008 -0.073 0.089 0.851 0.949 0.035 -0.039 0.109 0.350 0.576 0.015 -0.043 0.073 0.622 0.826 0.013 -0.064 0.089 0.741 0.863Cer(d16:1/16:0) -0.007 -0.078 0.064 0.854 0.949 0.017 -0.046 0.080 0.602 0.778 -0.034 -0.080 0.013 0.155 0.446 -0.036 -0.101 0.029 0.274 0.483Cer(d19:1/18:0) 0.006 -0.060 0.072 0.856 0.950 0.029 -0.029 0.088 0.324 0.557 -0.008 -0.051 0.036 0.734 0.887 -0.065 -0.125 -0.004 0.036 0.180PE(P-18:1/22:5) (a) -0.007 -0.079 0.066 0.857 0.950 0.038 -0.025 0.102 0.238 0.481 0.037 -0.014 0.088 0.155 0.446 0.010 -0.056 0.076 0.767 0.874PE(O-18:1/18:2) -0.006 -0.077 0.065 0.868 0.959 -0.010 -0.073 0.053 0.759 0.885 0.065 0.018 0.112 0.007 0.081 0.047 -0.018 0.112 0.156 0.359PE(P-18:1/18:2) (a) 0.006 -0.066 0.078 0.868 0.959 0.004 -0.059 0.067 0.905 0.960 0.073 0.026 0.121 0.003 0.041 0.078 0.012 0.143 0.020 0.128TG(50:2) [NL-16:1] 0.007 -0.071 0.084 0.870 0.960 0.066 -0.006 0.137 0.072 0.282 -0.056 -0.111 0.000 0.048 0.245 -0.077 -0.152 -0.002 0.044 0.194PC(36:6) (a) 0.006 -0.071 0.083 0.876 0.961 0.007 -0.062 0.075 0.849 0.938 -0.031 -0.082 0.020 0.227 0.537 -0.040 -0.111 0.031 0.267 0.475PC(14:0_20:4) 0.007 -0.076 0.089 0.877 0.961 0.064 -0.009 0.136 0.085 0.302 -0.039 -0.094 0.016 0.163 0.454 -0.100 -0.176 -0.024 0.010 0.089PE(P-18:1/18:2) (b) -0.005 -0.073 0.062 0.876 0.961 0.064 0.004 0.125 0.036 0.197 0.019 -0.033 0.070 0.479 0.737 -0.043 -0.106 0.019 0.174 0.379LPI(18:2) [sn2] 0.005 -0.062 0.072 0.875 0.961 0.064 0.005 0.124 0.033 0.190 -0.015 -0.060 0.030 0.524 0.773 -0.023 -0.085 0.039 0.462 0.676TG(56:7) [NL-20:4] -0.005 -0.071 0.061 0.877 0.961 0.043 -0.015 0.102 0.146 0.381 0.029 -0.018 0.075 0.224 0.534 -0.034 -0.095 0.028 0.287 0.504DG(18:2_20:4) 0.006 -0.076 0.089 0.879 0.961 0.013 -0.060 0.085 0.736 0.868 0.001 -0.055 0.056 0.982 0.992 -0.072 -0.148 0.004 0.063 0.238PC(38:4) (b) -0.006 -0.086 0.074 0.881 0.961 0.124 0.055 0.193 0.000 0.021 -0.036 -0.094 0.023 0.233 0.546 -0.068 -0.141 0.005 0.067 0.248TG(O-50:2) [NL-18:2] -0.005 -0.072 0.062 0.881 0.961 -0.021 -0.082 0.040 0.493 0.686 0.063 0.017 0.110 0.007 0.083 0.010 -0.053 0.073 0.756 0.874TG(50:3) [NL-18:3] 0.006 -0.075 0.087 0.884 0.963 0.046 -0.030 0.122 0.238 0.481 -0.015 -0.073 0.043 0.620 0.825 -0.039 -0.120 0.041 0.342 0.569Cer(m18:1/24:1) -0.005 -0.085 0.074 0.893 0.965 -0.040 -0.110 0.030 0.262 0.493 -0.019 -0.071 0.033 0.471 0.737 -0.064 -0.137 0.008 0.081 0.268SM(d18:2/16:0) -0.007 -0.110 0.096 0.892 0.965 0.024 -0.066 0.114 0.602 0.778 0.004 -0.065 0.073 0.909 0.962 -0.083 -0.177 0.011 0.085 0.270PC(16:0_20:3) (a) 0.006 -0.082 0.094 0.895 0.965 0.105 0.030 0.179 0.006 0.080 0.003 -0.062 0.068 0.917 0.964 -0.041 -0.120 0.038 0.313 0.538PC(38:7) (c) 0.006 -0.075 0.086 0.890 0.965 -0.008 -0.075 0.060 0.822 0.922 -0.007 -0.064 0.051 0.815 0.925 -0.099 -0.169 -0.029 0.006 0.065PC(P-17:0/20:4) (a) 0.005 -0.065 0.075 0.891 0.965 0.044 -0.018 0.106 0.163 0.398 0.035 -0.012 0.082 0.141 0.424 -0.048 -0.112 0.017 0.146 0.353TG(O-54:4) [NL-18:2] 0.004 -0.062 0.071 0.895 0.965 -0.016 -0.076 0.044 0.605 0.778 0.077 0.029 0.124 0.001 0.027 0.028 -0.034 0.090 0.373 0.603TG(48:2) [NL-14:1] 0.006 -0.078 0.089 0.891 0.965 0.069 -0.007 0.146 0.074 0.286 -0.054 -0.113 0.005 0.072 0.302 -0.089 -0.168 -0.009 0.029 0.154PC(34:5) -0.005 -0.079 0.069 0.897 0.965 -0.024 -0.090 0.042 0.475 0.669 -0.023 -0.072 0.026 0.360 0.668 -0.022 -0.090 0.047 0.537 0.729PS(36:2) -0.004 -0.068 0.060 0.901 0.968 0.073 0.017 0.130 0.011 0.106 -0.042 -0.088 0.003 0.068 0.294 -0.026 -0.086 0.033 0.382 0.610PC(O-18:0/20:4) 0.004 -0.065 0.074 0.904 0.970 0.084 0.022 0.147 0.008 0.095 0.003 -0.045 0.052 0.889 0.955 -0.092 -0.157 -0.027 0.006 0.065AC(14:0) -0.004 -0.069 0.061 0.910 0.975 0.049 -0.009 0.107 0.097 0.312 -0.039 -0.082 0.004 0.076 0.313 -0.088 -0.148 -0.028 0.004 0.056PC(16:0_20:3) (b) -0.004 -0.082 0.073 0.911 0.975 0.087 0.018 0.156 0.014 0.116 -0.053 -0.108 0.002 0.058 0.270 -0.065 -0.138 0.008 0.080 0.268LPC(20:5) [sn1] 0.004 -0.066 0.074 0.919 0.976 -0.030 -0.093 0.033 0.347 0.575 -0.013 -0.059 0.034 0.591 0.811 0.003 -0.061 0.068 0.921 0.958PE(P-16:0/18:3) -0.004 -0.074 0.067 0.914 0.976 -0.009 -0.070 0.053 0.786 0.902 0.063 0.017 0.109 0.007 0.082 0.038 -0.026 0.102 0.248 0.459CE(15:0) 0.004 -0.070 0.078 0.917 0.976 0.026 -0.041 0.092 0.454 0.654 0.001 -0.049 0.050 0.976 0.990 0.029 -0.041 0.098 0.419 0.640AC(18:1) 0.004 -0.061 0.068 0.915 0.976 0.028 -0.030 0.087 0.340 0.572 -0.028 -0.074 0.019 0.240 0.553 -0.082 -0.143 -0.021 0.008 0.082CE(18:2) [+OH] 0.004 -0.073 0.081 0.919 0.976 0.002 -0.065 0.069 0.946 0.977 0.047 -0.004 0.098 0.071 0.302 -0.004 -0.074 0.065 0.902 0.948PC(18:1_22:6) (b) 0.003 -0.064 0.071 0.921 0.977 0.042 -0.017 0.101 0.162 0.398 -0.020 -0.075 0.034 0.462 0.730 -0.073 -0.134 -0.012 0.019 0.125Hex3Cer(d18:1/20:0) -0.004 -0.079 0.072 0.926 0.977 0.031 -0.037 0.099 0.370 0.583 -0.016 -0.068 0.036 0.540 0.779 -0.054 -0.124 0.016 0.129 0.331PC(O-16:0/20:4) -0.004 -0.079 0.072 0.923 0.977 0.033 -0.034 0.099 0.333 0.566 0.038 -0.013 0.090 0.144 0.427 -0.094 -0.162 -0.025 0.008 0.078AC(17:0) (a) -0.003 -0.068 0.062 0.926 0.977 0.048 -0.010 0.106 0.107 0.331 -0.025 -0.068 0.018 0.256 0.573 -0.083 -0.143 -0.023 0.007 0.073TG(52:2) [NL-18:2] -0.004 -0.086 0.079 0.926 0.977 0.023 -0.054 0.099 0.562 0.746 -0.042 -0.101 0.018 0.168 0.458 -0.064 -0.145 0.017 0.124 0.323PI(15-MHDA_18:2) & PI(17:0_18:2) 0.003 -0.073 0.080 0.930 0.979 0.081 0.013 0.150 0.019 0.143 -0.015 -0.067 0.036 0.552 0.783 -0.074 -0.145 -0.003 0.040 0.185SM(d16:1/19:0) -0.003 -0.073 0.068 0.940 0.981 0.027 -0.036 0.090 0.403 0.610 0.025 -0.023 0.073 0.308 0.623 -0.056 -0.122 0.010 0.094 0.278SM(d18:1/16:0) -0.004 -0.098 0.091 0.940 0.981 0.004 -0.077 0.085 0.921 0.964 0.028 -0.040 0.097 0.421 0.709 -0.117 -0.203 -0.031 0.008 0.079PC(18:2_20:5) 0.003 -0.073 0.078 0.943 0.981 -0.032 -0.100 0.036 0.352 0.576 0.015 -0.035 0.065 0.553 0.783 0.015 -0.055 0.085 0.672 0.824PC(P-15:0/20:4) (b) -0.003 -0.070 0.064 0.935 0.981 0.009 -0.050 0.067 0.774 0.894 0.063 0.020 0.107 0.004 0.057 0.039 -0.022 0.100 0.215 0.422PC(39:5) (a) -0.003 -0.074 0.068 0.938 0.981 -0.062 -0.125 0.002 0.056 0.254 -0.018 -0.065 0.030 0.461 0.730 0.021 -0.045 0.086 0.539 0.729PE(15-MHDA_22:6) 0.003 -0.073 0.079 0.940 0.981 -0.055 -0.123 0.014 0.116 0.344 0.004 -0.047 0.054 0.885 0.954 -0.011 -0.081 0.059 0.748 0.868PC(P-20:0/20:4) -0.003 -0.076 0.070 0.933 0.981 0.047 -0.019 0.113 0.164 0.398 -0.012 -0.062 0.038 0.637 0.835 -0.097 -0.165 -0.030 0.005 0.061AC(14:2) -0.002 -0.068 0.064 0.944 0.981 0.038 -0.021 0.096 0.209 0.452 -0.019 -0.063 0.024 0.385 0.678 -0.049 -0.111 0.012 0.115 0.307methyl-CE(22:6) 0.003 -0.080 0.085 0.946 0.981 -0.065 -0.139 0.008 0.080 0.292 0.039 -0.015 0.093 0.155 0.446 0.052 -0.023 0.127 0.175 0.381AC(17:0) (b) -0.002 -0.068 0.064 0.945 0.981 0.028 -0.031 0.086 0.357 0.578 -0.019 -0.062 0.025 0.398 0.691 -0.040 -0.101 0.021 0.194 0.398TG(52:5) [NL-20:4] -0.003 -0.088 0.082 0.943 0.981 0.072 -0.005 0.148 0.067 0.272 -0.034 -0.092 0.024 0.254 0.572 -0.097 -0.178 -0.016 0.019 0.125TG(49:1) [NL-16:1] -0.002 -0.072 0.067 0.947 0.981 0.042 -0.021 0.105 0.190 0.427 -0.028 -0.077 0.021 0.258 0.574 -0.061 -0.127 0.004 0.067 0.248SHexCer(d18:1/24:0) -0.002 -0.079 0.074 0.954 0.981 -0.057 -0.123 0.009 0.092 0.310 0.038 -0.010 0.086 0.125 0.398 0.045 -0.023 0.113 0.195 0.398PC(31:0) (b) 0.002 -0.066 0.070 0.952 0.981 0.039 -0.023 0.100 0.215 0.456 -0.030 -0.076 0.015 0.192 0.494 -0.013 -0.076 0.051 0.698 0.840PE(16:0_16:1) 0.002 -0.076 0.080 0.954 0.981 0.070 0.000 0.140 0.050 0.238 -0.069 -0.121 -0.016 0.011 0.110 -0.068 -0.141 0.005 0.069 0.249PC(P-18:1/22:6) 0.002 -0.080 0.085 0.953 0.981 -0.078 -0.150 -0.007 0.032 0.188 0.084 0.028 0.140 0.003 0.049 0.007 -0.066 0.081 0.848 0.916LPE(P-18:0) 0.002 -0.065 0.069 0.951 0.981 -0.005 -0.064 0.054 0.872 0.944 0.021 -0.025 0.067 0.372 0.673 0.012 -0.049 0.073 0.698 0.840LPC(20:5) [sn2] 0.002 -0.069 0.073 0.960 0.984 -0.037 -0.100 0.027 0.256 0.492 -0.013 -0.060 0.034 0.576 0.804 -0.005 -0.070 0.060 0.883 0.937AC(20:5) 0.002 -0.068 0.072 0.959 0.984 -0.065 -0.128 -0.002 0.043 0.218 -0.008 -0.058 0.042 0.762 0.900 0.064 -0.001 0.130 0.054 0.212methyl-CE(18:2) -0.002 -0.076 0.072 0.960 0.984 0.007 -0.060 0.075 0.828 0.927 0.041 -0.009 0.091 0.106 0.368 0.070 0.001 0.139 0.048 0.200Cer(d20:1/24:1) -0.001 -0.068 0.065 0.968 0.985 -0.035 -0.095 0.025 0.249 0.492 0.005 -0.041 0.050 0.842 0.932 -0.052 -0.114 0.009 0.095 0.278SM(40:3) (b) -0.002 -0.073 0.070 0.966 0.985 0.122 0.060 0.184 0.000 0.016 -0.047 -0.103 0.009 0.101 0.364 -0.127 -0.192 -0.062 0.000 0.012PC(14:0_22:6) -0.002 -0.080 0.077 0.966 0.985 -0.041 -0.111 0.028 0.244 0.490 0.000 -0.053 0.052 0.991 0.994 -0.048 -0.121 0.024 0.188 0.394PC(18:0_22:5) (n3) & PC(20:1_20:4) -0.001 -0.074 0.071 0.968 0.985 0.052 -0.012 0.116 0.111 0.334 -0.051 -0.100 -0.003 0.037 0.212 0.001 -0.066 0.067 0.988 0.994CE(22:5) -0.002 -0.082 0.078 0.964 0.985 0.083 0.014 0.152 0.018 0.141 -0.045 -0.099 0.010 0.108 0.371 -0.095 -0.167 -0.023 0.010 0.089CE(16:1) 0.001 -0.070 0.073 0.970 0.985 0.049 -0.014 0.113 0.126 0.357 -0.055 -0.103 -0.007 0.025 0.177 -0.066 -0.132 0.000 0.051 0.207Cer(m18:0/24:1) 0.001 -0.078 0.081 0.975 0.988 -0.044 -0.114 0.025 0.208 0.452 -0.010 -0.063 0.042 0.700 0.875 -0.095 -0.167 -0.022 0.011 0.089SM(d18:1/24:1) -0.001 -0.083 0.080 0.977 0.988 -0.065 -0.138 0.007 0.077 0.288 0.043 -0.011 0.096 0.119 0.391 -0.058 -0.135 0.019 0.138 0.341PA(34:1) 0.001 -0.072 0.074 0.975 0.988 0.001 -0.062 0.064 0.970 0.982 -0.002 -0.048 0.045 0.941 0.973 0.011 -0.055 0.076 0.751 0.870SM(d18:0/14:0) -0.001 -0.081 0.078 0.979 0.989 0.034 -0.037 0.105 0.347 0.575 -0.003 -0.056 0.051 0.926 0.968 -0.016 -0.090 0.059 0.681 0.829SM(d18:1/14:0) & SM(d16:1/16:0) -0.001 -0.085 0.084 0.988 0.993 0.036 -0.038 0.110 0.341 0.572 -0.013 -0.067 0.042 0.653 0.848 -0.052 -0.128 0.024 0.180 0.386PE(17:0_20:4) 0.001 -0.076 0.078 0.986 0.993 0.051 -0.019 0.121 0.153 0.385 -0.024 -0.077 0.030 0.385 0.678 -0.088 -0.160 -0.016 0.017 0.117FA(20:2) 0.000 -0.065 0.066 0.989 0.993 -0.015 -0.074 0.044 0.622 0.783 -0.001 -0.045 0.042 0.958 0.981 -0.053 -0.114 0.008 0.088 0.275CE(16:0) 0.001 -0.079 0.080 0.986 0.993 0.029 -0.042 0.099 0.421 0.622 -0.025 -0.082 0.032 0.385 0.678 -0.095 -0.168 -0.022 0.010 0.089methyl-CE(18:0) -0.001 -0.073 0.072 0.985 0.993 0.019 -0.044 0.083 0.551 0.741 0.031 -0.017 0.078 0.210 0.518 -0.025 -0.092 0.041 0.455 0.668SHexCer(d18:1/16:0) 0.000 -0.075 0.074 0.991 0.994 0.017 -0.050 0.083 0.621 0.783 0.003 -0.047 0.053 0.915 0.964 -0.089 -0.158 -0.021 0.011 0.089PC(17:0_22:6) 0.000 -0.070 0.070 0.993 0.994 -0.075 -0.137 -0.013 0.019 0.141 0.039 -0.008 0.086 0.104 0.368 -0.003 -0.067 0.062 0.938 0.968TG(48:1) [NL-18:1] 0.000 -0.079 0.079 0.999 0.999 0.035 -0.039 0.108 0.353 0.576 -0.040 -0.095 0.015 0.154 0.446 -0.028 -0.105 0.049 0.479 0.689 ### Page 19 Supplementary Table 3. Associations of lipid classes with baseline A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid classes Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)LPC(O) 0.121 0.053 0.189 0.001 0.024 0.056 -0.006 0.118 0.076 0.414 -0.033 -0.085 0.019 0.211 0.649 -0.111 -0.175 -0.047 0.001 0.011LPC 0.119 0.047 0.192 0.001 0.030 0.064 -0.001 0.128 0.054 0.414 -0.012 -0.064 0.039 0.638 0.889 -0.055 -0.122 0.012 0.110 0.224LPC(P) 0.096 0.027 0.165 0.006 0.047 0.049 -0.012 0.111 0.115 0.414 -0.009 -0.061 0.043 0.734 0.916 -0.080 -0.144 -0.017 0.013 0.071LPE 0.104 0.030 0.178 0.006 0.047 0.060 -0.006 0.127 0.074 0.414 -0.044 -0.095 0.006 0.086 0.360 -0.070 -0.139 0.000 0.048 0.137Hex2Cer 0.115 0.035 0.194 0.005 0.047 0.062 -0.009 0.132 0.085 0.414 -0.030 -0.082 0.022 0.254 0.649 -0.055 -0.129 0.019 0.146 0.269DE -0.127 -0.213 -0.041 0.004 0.047 -0.077 -0.153 -0.002 0.045 0.414 0.029 -0.026 0.084 0.299 0.687 0.055 -0.023 0.133 0.170 0.300PE(O) -0.095 -0.169 -0.022 0.011 0.073 -0.051 -0.117 0.014 0.126 0.414 0.064 0.014 0.113 0.012 0.094 0.014 -0.054 0.082 0.689 0.754HexCer 0.089 0.015 0.163 0.018 0.106 0.024 -0.041 0.090 0.465 0.684 -0.016 -0.065 0.033 0.515 0.845 -0.018 -0.086 0.051 0.609 0.700GM1 0.079 0.007 0.150 0.030 0.148 0.003 -0.059 0.065 0.921 0.935 -0.056 -0.103 -0.009 0.020 0.135 -0.085 -0.151 -0.020 0.011 0.071PE(P) -0.082 -0.158 -0.007 0.032 0.148 -0.031 -0.096 0.035 0.361 0.594 0.091 0.040 0.142 0.001 0.008 0.022 -0.046 0.090 0.528 0.639deDE 0.077 0.002 0.152 0.045 0.174 0.070 0.004 0.136 0.038 0.414 -0.149 -0.197 -0.102 0.000 0.000 -0.140 -0.208 -0.073 0.000 0.002dhCer -0.081 -0.160 -0.002 0.045 0.174 -0.038 -0.108 0.031 0.279 0.584 0.034 -0.018 0.086 0.199 0.649 0.007 -0.065 0.080 0.848 0.907OxSpecies 0.064 -0.008 0.135 0.082 0.291 -0.010 -0.074 0.053 0.752 0.805 0.009 -0.040 0.058 0.725 0.916 -0.052 -0.117 0.013 0.117 0.224GM3 0.058 -0.026 0.143 0.174 0.500 0.043 -0.032 0.117 0.262 0.574 -0.029 -0.091 0.033 0.355 0.743 -0.136 -0.213 -0.058 0.001 0.011dimethyl-CE -0.052 -0.126 0.022 0.167 0.500 -0.055 -0.122 0.011 0.105 0.414 0.082 0.032 0.131 0.001 0.014 0.083 0.015 0.151 0.017 0.078TG(O) [NL] -0.051 -0.123 0.020 0.157 0.500 -0.050 -0.114 0.014 0.125 0.414 0.119 0.070 0.169 0.000 0.000 0.017 -0.050 0.083 0.626 0.703S1P 0.044 -0.022 0.110 0.194 0.525 0.071 0.012 0.130 0.018 0.414 -0.016 -0.062 0.030 0.497 0.845 -0.022 -0.083 0.040 0.490 0.633methyl-DE -0.045 -0.121 0.031 0.244 0.565 -0.019 -0.088 0.050 0.591 0.718 0.074 0.023 0.124 0.004 0.039 0.097 0.027 0.168 0.007 0.071SHexCer 0.050 -0.034 0.134 0.246 0.565 -0.023 -0.097 0.051 0.543 0.718 0.003 -0.051 0.058 0.904 0.970 -0.069 -0.145 0.008 0.079 0.191LPI -0.042 -0.111 0.028 0.240 0.565 0.038 -0.023 0.098 0.224 0.531 0.004 -0.044 0.051 0.878 0.970 -0.030 -0.094 0.034 0.350 0.520DG -0.066 -0.193 0.061 0.309 0.592 -0.051 -0.158 0.055 0.343 0.585 -0.031 -0.114 0.052 0.465 0.822 -0.125 -0.235 -0.015 0.026 0.085AC-OH -0.035 -0.100 0.031 0.298 0.592 0.008 -0.050 0.067 0.781 0.817 -0.012 -0.056 0.032 0.590 0.876 -0.070 -0.130 -0.009 0.024 0.085Cer(d) 0.042 -0.036 0.120 0.292 0.592 0.047 -0.023 0.117 0.184 0.498 -0.013 -0.066 0.040 0.638 0.889 -0.060 -0.132 0.013 0.105 0.224SM -0.052 -0.147 0.044 0.291 0.592 0.024 -0.060 0.107 0.577 0.718 0.073 0.006 0.140 0.032 0.164 -0.037 -0.126 0.052 0.414 0.577COH 0.042 -0.045 0.129 0.344 0.633 -0.003 -0.077 0.071 0.935 0.935 0.007 -0.054 0.068 0.823 0.970 -0.100 -0.180 -0.020 0.014 0.071Cer(m) -0.040 -0.125 0.046 0.361 0.639 -0.026 -0.100 0.048 0.490 0.684 0.003 -0.053 0.059 0.925 0.970 -0.038 -0.115 0.039 0.337 0.517PC(O) 0.032 -0.053 0.118 0.460 0.707 0.046 -0.028 0.120 0.220 0.531 0.033 -0.027 0.093 0.285 0.687 -0.081 -0.158 -0.004 0.040 0.124FFA -0.025 -0.093 0.042 0.461 0.707 -0.013 -0.073 0.048 0.683 0.786 0.000 -0.044 0.045 0.995 0.995 -0.058 -0.120 0.004 0.068 0.173PIP1 0.027 -0.038 0.092 0.416 0.707 0.050 -0.008 0.108 0.093 0.414 0.012 -0.031 0.056 0.578 0.876 0.003 -0.057 0.063 0.930 0.972LPE(P) 0.025 -0.042 0.092 0.458 0.707 0.016 -0.043 0.076 0.587 0.718 0.019 -0.028 0.066 0.424 0.780 0.001 -0.061 0.062 0.986 0.986CE 0.037 -0.072 0.145 0.510 0.711 0.067 -0.026 0.160 0.156 0.447 -0.012 -0.086 0.063 0.757 0.916 -0.123 -0.221 -0.025 0.014 0.071PC 0.035 -0.067 0.136 0.504 0.711 0.078 -0.009 0.165 0.077 0.414 -0.022 -0.095 0.050 0.547 0.867 -0.108 -0.199 -0.017 0.020 0.085Sph 0.022 -0.041 0.086 0.494 0.711 -0.023 -0.079 0.034 0.435 0.667 0.007 -0.036 0.050 0.746 0.916 0.020 -0.039 0.079 0.509 0.633Ubiquinone -0.020 -0.087 0.046 0.548 0.741 0.021 -0.038 0.080 0.490 0.684 -0.005 -0.051 0.041 0.845 0.970 -0.002 -0.063 0.060 0.960 0.982PA 0.019 -0.053 0.092 0.602 0.785 -0.010 -0.074 0.053 0.751 0.805 0.024 -0.023 0.070 0.317 0.693 0.057 -0.009 0.123 0.089 0.204PI -0.022 -0.107 0.063 0.614 0.785 0.063 -0.013 0.139 0.103 0.414 -0.002 -0.061 0.057 0.952 0.973 -0.064 -0.143 0.015 0.112 0.224BA -0.014 -0.078 0.051 0.671 0.835 0.030 -0.028 0.087 0.311 0.585 0.025 -0.018 0.068 0.252 0.649 0.020 -0.039 0.080 0.505 0.633methyl-CE -0.012 -0.086 0.061 0.745 0.865 -0.012 -0.078 0.055 0.735 0.805 0.055 0.005 0.104 0.031 0.164 0.034 -0.034 0.103 0.327 0.517C1P 0.014 -0.072 0.100 0.752 0.865 0.037 -0.039 0.113 0.343 0.585 0.003 -0.054 0.059 0.928 0.970 -0.039 -0.116 0.038 0.324 0.517PS 0.012 -0.052 0.076 0.721 0.865 0.025 -0.032 0.082 0.391 0.621 -0.009 -0.051 0.033 0.686 0.916 0.017 -0.042 0.076 0.567 0.668PE -0.013 -0.102 0.077 0.783 0.878 0.044 -0.038 0.125 0.292 0.584 -0.039 -0.101 0.023 0.219 0.649 -0.053 -0.137 0.030 0.210 0.358TG [NL] -0.013 -0.117 0.092 0.810 0.887 0.070 -0.025 0.164 0.148 0.447 -0.053 -0.128 0.022 0.169 0.649 -0.116 -0.216 -0.016 0.024 0.085Hex3Cer -0.008 -0.100 0.083 0.861 0.922 0.022 -0.059 0.103 0.593 0.718 -0.026 -0.089 0.037 0.416 0.780 -0.113 -0.195 -0.030 0.008 0.071AC 0.003 -0.063 0.070 0.924 0.945 0.029 -0.031 0.089 0.340 0.585 -0.019 -0.064 0.025 0.390 0.780 -0.062 -0.124 0.000 0.051 0.137PG -0.005 -0.109 0.099 0.922 0.945 -0.057 -0.149 0.036 0.231 0.531 -0.042 -0.111 0.027 0.236 0.649 -0.037 -0.131 0.058 0.447 0.604PC(P) 0.001 -0.089 0.091 0.981 0.981 0.016 -0.060 0.093 0.673 0.786 0.054 -0.005 0.114 0.074 0.340 -0.037 -0.116 0.042 0.364 0.52395% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper) ### Page 20 Supplementary Table 4. Lipid species in modules identified with WGCNAModule Lipid speciesM1 28M2 60M3 48M4 5M5 14M6 11M7 11M8 8M9 9M10 11M11 5 AC(18:2), AC(18:3), AC(20:3) (a), AC(20:3) (b), AC(20:4)M12 11M13 11M14 5 PI(38:5) (b), PI(15-MHDA_18:2) & PI(17:0_18:2), PI(16:0_20:3) (a), PI(18:1_18:2), PI(36:2)M15 31M16 19M17 12M18 5 CE(16:2), CE(18:3), DE(18:2), deDE(18:2), deDE(20:4)Number of Lipid speciesPE(15-MHDA_18:1), PE(15-MHDA_18:2), PE(15-MHDA_20:4), PE(16:0_16:1), PE(16:0_18:1), PE(16:0_18:2), PE(16:0_18:3) (a), PE(16:0_18:3) (b), PE(16:0_20:3), PE(16:0_20:4), PE(16:1_18:2), PE(16:1_20:4), PE(17:0_18:1), PE(17:0_18:2), PE(17:0_20:4), PE(18:0_18:1), PE(18:0_18:2), PE(18:0_20:3) (a), PE(18:0_20:3) (b), PE(18:0_20:4), PE(18:0_22:4), PE(18:0_22:5) (n3), PE(18:0_22:5) (n6), PE(18:1_18:1), PE(18:1_18:2), PE(20:0_20:4), PE(38:5) (a), PE(38:5) (b)PE(16:0_16:0), PG(34:1), PG(36:1), PG(36:2), CE(20:4), DE(20:4), DG(14:0_16:0), DG(14:0_18:2), DG(16:0_16:0), DG(16:0_16:1), DG(16:0_18:1), DG(16:1_18:1), DG(18:0_18:1), DG(18:0_18:2), DG(18:1_18:1), TG(48:0) [NL-16:0], TG(48:0) [NL-18:0], TG(48:1) [NL-16:1], TG(48:1) [NL-18:1], TG(48:2) [NL-14:0], TG(48:2) [NL-14:1], TG(48:2) [NL-16:1], TG(48:2) [NL-18:2], TG(48:3) [NL-14:0], TG(48:3) [NL-16:1], TG(48:3) [NL-18:3], TG(49:1) [NL-16:1], TG(49:1) [NL-17:1], TG(50:0) [NL-18:0], TG(50:1) [NL-14:0], TG(50:1) [NL-16:0], TG(50:1) [NL-18:1], TG(50:2) [NL-14:0], TG(50:2) [NL-16:1], TG(50:2) [NL-18:1], TG(50:2) [NL-18:2], TG(50:3) [NL-14:0], TG(50:3) [NL-14:1], TG(50:3) [NL-16:1], TG(50:3) [NL-18:2], TG(50:3) [NL-18:3], TG(50:4) [NL-14:0], TG(50:4) [NL-18:3], TG(50:4) [NL-20:4], TG(51:0) [NL-16:0], TG(51:1) [NL-17:0], TG(51:2) [NL-15:0], TG(51:2) [NL-17:0], TG(51:2) [NL-17:1], TG(52:1) [NL-18:0], TG(52:1) [NL-18:1], TG(52:2) [NL-16:0], TG(52:2) [NL-18:2], TG(52:4) [NL-18:3], TG(53:2) [NL-17:1], TG(53:2) [NL-18:1], TG(54:0) [NL-18:0], TG(54:1) [NL-18:1], TG(54:2) [NL-18:0], TG(54:2) [NL-20:1]LPC(15-MHDA) [sn1] [104_sn1], LPC(15-MHDA) [sn1] & LPC(17:0) [sn2], LPC(15-MHDA) [sn2], LPC(15:0) [sn1], LPC(15:0) [sn2], LPC(16:0) [sn1], LPC(16:0) [sn2], LPC(16:1) [sn1], LPC(16:1) [sn2], LPC(17:0) [sn1], LPC(17:1) (a) [sn1] [104_sn1], LPC(17:1) [sn1] (a) & LPC(17:1) [sn2] (b), LPC(17:1) [sn1] (b), LPC(17:1) [sn2] (a), LPC(18:0) [sn1], LPC(18:0) [sn2], LPC(18:1) [sn1], LPC(18:1) [sn2], LPC(19:0) (a) [sn1] [104_sn1], LPC(19:0) [sn1] (a) & LPC(19:0) [sn2] (b), LPC(19:0) [sn1] (b), LPC(19:0) [sn2] (a), LPC(19:1) (a), LPC(19:1) (b), LPC(19:1) (c), LPC(20:1) [sn1], LPC(20:1) [sn2], LPC(20:2) [sn1], LPC(20:2) [sn2], LPC(22:1) [sn1], LPC(22:1) [sn2], LPC(O-16:0), LPC(O-18:0), LPC(O-18:1), LPC(P-16:0), LPC(P-17:0) (a), LPC(P-17:0) (b), LPC(P-18:0), LPC(P-18:1), LPE(16:0) [sn1], LPE(16:0) [sn2], LPE(18:0) [sn1], LPE(18:0) [sn2], LPE(P-16:0), LPE(P-18:0), LPE(P-18:1), LPE(P-20:0), AC(24:1)-OHPC(18:0_22:5) (n3) & PC(20:1_20:4), PC(39:5) (b), LPC(22:5) (n3) [sn1] [104_sn1], LPC(22:5) [sn1] (n3) & LPC(22:5) [sn2] (n6), LPC(22:5) [sn2] (n3)FA(14:0), FA(16:0), FA(16:1), FA(17:0), FA(17:1), FA(18:0), FA(18:1), FA(18:2), FA(18:3), FA(20:2), FA(20:3), FA(20:4), FA(22:4), FA(22:5)PC(15-MHDA_20:4), PC(15:0_20:4), PC(16:0_20:4), PC(16:1_20:4), PC(17:0_20:4), PC(18:0_20:4), PC(38:5) (a), TG(56:6) [NL-20:4], TG(56:7) [NL-20:4], CE(20:4) [+OH], PC(36:4) [+OH]PC(20:0_20:4), LPC(20:0) [sn1], LPC(20:0) [sn2], LPC(22:0) [sn1], LPC(22:0) [sn2], LPC(24:0) [sn1], LPC(24:0) [sn2], LPC(26:0) [sn1], LPC(26:0) [sn2], PI(20:0_20:4), AC(24:0)PE(P-16:0/20:4), PE(P-17:0/20:4) (b), PE(P-18:0/20:4), PE(P-18:1/20:4) (a), PE(P-19:0/20:4) (a), PE(P-19:0/20:4) (b), PE(P-20:0/20:4), PE(P-20:1/20:4)SHexCer(d18:1/24:0(OH)), SM(d16:1/23:0) & SM(d17:1/22:0), SM(d18:1/20:0) & SM(d16:1/22:0), SM(d18:1/22:0) & SM(d16:1/24:0), SM(d18:1/23:0) & SM(d17:1/24:0), SM(d18:1/24:0), SM(d18:2/22:0), SM(d18:2/23:0), SM(d18:2/24:0)PC(O-32:1), PC(O-32:2), PC(O-34:4), PC(O-35:4), PC(P-15:0/20:4) (a), PC(P-15:0/20:4) (b), PC(P-17:0/20:4) (a), PC(P-17:0/20:4) (b), PE(P-15:0/20:4) (a), PE(P-15:0/20:4) (b), PE(P-17:0/20:4) (a)methyl-CE(18:0), methyl-CE(18:1), methyl-CE(18:2), methyl-CE(20:4), methyl-CE(22:6), methyl- DE(18:1), methyl-DE(18:2), dimethyl-CE(18:1), dimethyl-CE(18:2), dimethyl-CE(20:4), dimethyl- CE(22:6)CE(18:0), CE(20:0), CE(20:1), CE(20:2), CE(22:0), CE(22:1), CE(24:0), CE(24:1), CE(24:4), CE(24:5), CE(18:2) [+OH]PE(O-16:0/18:2), PE(O-16:0/20:3), PE(O-16:0/20:4), PE(O-18:0/20:4), PE(O-18:0/22:5), PE(O-18:1/18:2), PE(O-34:1), PE(O-38:5) (a), PE(P-16:0/18:1), PE(P-16:0/18:2), PE(P-16:0/18:3), PE(P-16:0/20:3) (a), PE(P-16:0/20:3) (b), PE(P-16:0/22:5) (n3), PE(P-18:0/18:1), PE(P-18:0/18:2), PE(P-18:0/18:3), PE(P-18:0/20:3) (a), PE(P-18:0/20:3) (b), PE(P-18:0/22:5) (n3), PE(P-18:1/18:1) (a), PE(P-18:1/18:1) (b), PE(P-18:1/18:2) (a), PE(P-18:1/18:2) (b), PE(P-18:1/18:3), PE(P-18:1/20:3) (a), PE(P-18:1/20:3) (b), PE(P-18:1/20:4) (b), PE(P-18:1/22:5) (a), PE(P-20:0/18:1), PE(P-20:0/18:2)TG(O-50:1) [NL-15:0], TG(O-50:1) [NL-16:0], TG(O-50:1) [NL-17:1], TG(O-50:1) [NL-18:1], TG(O-50:2) [NL-18:1], TG(O-50:2) [NL-18:2], TG(O-50:3) [NL-18:2], TG(O-52:0) [NL-16:0], TG(O-52:1) [NL-16:0], TG(O-52:1) [NL-18:1], TG(O-52:2) [NL-16:0], TG(O-52:2) [NL-17:1], TG(O-52:2) [NL-18:1], TG(O-54:2) [NL-17:1], TG(O-54:2) [NL-18:1], TG(O-54:3) [NL-17:1], TG(O-54:3) [NL-18:1], TG(O-54:4) [NL-17:1], TG(O-54:4) [NL-18:2]Cer(d19:1/16:0), Cer(d19:1/18:0), Cer(d19:1/20:0), Cer(d19:1/22:0), Cer(d19:1/23:0), Cer(d19:1/24:0), Cer(d19:1/24:1), Cer(d19:1/26:0), Cer(d20:1/22:0), Cer(d20:1/23:0), Cer(d20:1/24:0), Cer(d20:1/24:1) ### Page 21 M19 14M20 6 LPI(18:1) [sn1], LPI(18:1) [sn2], LPI(18:2) [sn1], LPI(18:2) [sn2], LPI(20:4) [sn1], LPI(20:4) [sn2]M21 12M22 6M23 12M24 23M25 7 AC(15:0) (b), AC(16:0), AC(17:0) (a), AC(17:0) (b), AC(18:0), AC(24:1), AC(26:1)M26 14M27 11M28 7M29 10M30 26M31 7M32 20M33 30M34 11M35 10M36 14M37 8M38 10M39 8M40 10M41 19HexCer(d16:1/18:0), HexCer(d16:1/20:0), HexCer(d16:1/22:0), HexCer(d16:1/24:0), HexCer(d18:1/16:0), HexCer(d18:1/18:0), HexCer(d18:1/20:0), HexCer(d18:1/22:0), HexCer(d18:1/24:0), HexCer(d18:1/24:1), HexCer(d18:2/18:0), HexCer(d18:2/20:0), HexCer(d18:2/22:0), HexCer(d18:2/24:0)PC(18:0_22:4), PC(18:0_22:5) (n6), PC(38:4) (b), LPC(20:4) [sn1], LPC(20:4) [sn2], LPC(22:4) [sn1], LPC(22:4) [sn2], LPC(22:5) [sn1] (n6), LPE(20:4) [sn1], LPE(20:4) [sn2], PI(18:0_22:4), PI(18:0_22:5) (n6)PE(15-MHDA_22:6), PE(16:0_22:6), PE(17:0_22:6), PE(18:0_22:6), PE(18:1_22:6) (a), PE(18:1_22:6) (b)SM(34:3), SM(37:2), SM(38:3) (a), SM(38:3) (b), SM(40:3) (a), SM(40:3) (b), SM(d18:1/18:0) & SM(d16:1/20:0), SM(d18:2/16:0), SM(d18:2/17:0), SM(d18:2/18:0), SM(d18:2/18:1), SM(d18:2/20:0)PC(14:0_22:6), PC(16:0_20:5), PC(18:2_20:5), PC(34:5), PC(35:5), PC(36:6) (a), PC(38:5) (b), PC(O-36:5), PC(P-16:0/20:5), LPC(20:5) [sn1], LPC(20:5) [sn2], PE(16:0_20:5), PE(O-36:5), PE(P-15:0/22:6) (a), PE(P-16:0/20:5), PE(P-18:0/20:5), PE(P-18:1/20:5) (a), PE(P-18:1/20:5) (b), LPE(22:6) [sn1], LPE(22:6) [sn2], CE(20:5), DE(20:5), FA(20:5)AC(12:0), AC(12:1), AC(14:0), AC(14:1), AC(14:2), AC(16:1), AC(18:1), AC(14:0)-OH, AC(14:1)-OH, AC(16:0)-OH, AC(16:1)-OH, AC(18:0)-OH, AC(18:1)-OH, AC(20:3)-OHCer(m18:0/20:0), Cer(m18:0/22:0), Cer(m18:0/23:0), Cer(m18:0/24:0), Cer(m18:0/24:1), Cer(m18:1/18:0), Cer(m18:1/20:0), Cer(m18:1/22:0), Cer(m18:1/23:0), Cer(m18:1/24:0), Cer(m18:1/24:1)SM(37:1), SM(41:1) (a), SM(43:1), SM(44:1), SM(d16:1/19:0), SM(d18:1/17:0) & SM(d17:1/18:0), SM(d19:1/24:1)DG(16:0_20:4), DG(18:0_20:4), DG(18:1_20:3), DG(18:1_20:4), DG(18:2_20:4), TG(52:5) [NL-20:4], TG(54:4) [NL-20:3], TG(54:5) [NL-20:4], TG(54:6) [NL-20:4], TG(56:8) [NL-20:4]PC(14:0_16:0), PC(14:0_20:4), PC(16:0_18:1), PC(16:0_18:3) (b), PC(16:0_20:3) (b), PC(18:0_18:1), PC(28:0), PC(32:1), PC(32:2), LPC(14:0) [sn1], LPC(14:0) [sn2], PI(15-MHDA_18:1) & PI(17:0_18:1), PI(15-MHDA_20:4) & PI(17:0_20:4), PI(16:0_16:1), PI(16:0_20:3) (b), PI(16:0_20:4), PI(16:0/16:0), PI(18:0_18:1), PI(18:0_20:3) (b), PI(18:0_20:4), PI(34:0), PI(34:1), PI(38:5) (a), CE(14:0), CE(16:1), PC(34:2) [+OH]PC(16:0_20:3) (a), PC(18:0_20:3), PC(18:1_20:3), PC(40:7) (a), LPC(20:3) [sn1], LPC(20:3) [sn2], CE(20:3)S1P(d16:1), Cer(d16:1/16:0), Cer(d16:1/22:0), Cer(d16:1/23:0), Cer(d16:1/24:0), Cer(d16:1/24:1), Cer(d17:1/22:0), Cer(d17:1/23:0), Cer(d17:1/24:0), Cer(d17:1/24:1), Cer(d18:1/22:0), Cer(d18:1/23:0), Cer(d18:1/24:0), Cer(d18:1/24:1), Cer(d18:1/26:0), Cer(d18:2/22:0), Cer(d18:2/23:0), Cer(d18:2/24:0), Cer(d18:2/24:1), Cer(d18:2/26:0)PS(40:5), PS(40:6), FA(22:6), AC(13:0), AC(15:0) (a), AC(20:5), AC(22:5), AC(22:6), AC(22:5)-OH, DG(16:0_22:5), DG(16:0_22:6), DG(18:1_20:5), DG(18:1_22:5), DG(18:1_22:6), DG(18:2_22:6), TG(52:5) [NL-20:5], TG(54:6) [NL-20:5], TG(54:6) [NL-22:6], TG(54:7) [NL-20:5], TG(54:7) [NL-22:6], TG(56:6) [NL-22:5], TG(56:7) [NL-20:5], TG(56:7) [NL-22:5], TG(56:7) [NL-22:6], TG(56:8) [NL-20:5], TG(56:8) [NL-22:6], TG(56:9) [NL-22:6], TG(58:10) [NL-22:6], TG(58:8) [NL-22:6], TG(58:9) [NL-22:6]LPC(18:2) [sn1], LPC(18:2) [sn2], LPC(18:3) (a) [sn1] [104_sn1], LPC(18:3) [sn1] (a) & LPC(18:3) [sn2] (b), LPC(18:3) [sn1] (b), LPC(18:3) [sn2] (a), LPE(18:1) [sn1], LPE(18:1) [sn2], LPE(18:2) [sn1], LPE(18:2) [sn2], LPC(18:2) [+OH]PC(O-16:0/20:4), PC(O-18:0/20:4), PC(O-38:5), PC(O-40:5), PC(P-16:0/20:4), PC(P-18:0/20:4), PC(P-18:0/22:5), PC(P-20:0/20:4), PC(P-38:5) (a), PC(P-38:5) (b)DG(16:0_18:2), DG(18:1_18:2), DG(18:1_18:3), DG(18:2_18:2), TG(52:3) [NL-16:1], TG(52:3) [NL-18:2], TG(52:4) [NL-16:1], TG(52:4) [NL-18:2], TG(52:5) [NL-18:3], TG(54:3) [NL-18:1], TG(54:3) [NL-18:2], TG(54:4) [NL-18:2], TG(54:5) [NL-18:3], TG(54:6) [NL-18:3]dhCer(d18:0/16:0), dhCer(d18:0/18:0), dhCer(d18:0/20:0), dhCer(d18:0/22:0), dhCer(d18:0/24:0), dhCer(d18:0/24:1), SM(41:0), SM(d18:0/22:0)Hex2Cer(d16:1/16:0), Hex2Cer(d16:1/24:1), Hex2Cer(d18:1/16:0), Hex2Cer(d18:1/20:0), Hex2Cer(d18:1/22:0), Hex2Cer(d18:1/24:0), Hex2Cer(d18:1/24:1), Hex2Cer(d18:2/16:0), Hex2Cer(d18:2/24:1), GM1(d18:1/16:0)LPC(O-20:0), LPC(O-20:1), LPC(O-22:0), LPC(O-22:1), LPC(O-24:0), LPC(O-24:1), LPC(O-24:2), LPC(P-20:0)Sph(d18:1), S1P(d18:0), S1P(d18:1), S1P(d18:2), PS(36:1), PS(36:2), PS(38:3), PS(38:4), LPC(20:4) [+OH], LPC(22:6) [+OH]Cer(d17:1/16:0), Cer(d18:1/14:0), Cer(d18:2/14:0), SM(d17:1/14:0), SM(d17:1/16:0), SM(d18:0/14:0), SM(d18:1/14:0) & SM(d16:1/16:0), SM(d18:2/14:0), PC(15-MHDA_18:1), PC(17:0_18:1), PC(31:0) (a), PC(31:0) (b), PC(33:0) (a), PC(33:0) (b), PC(33:1), PC(P-16:0/14:0), CE(15:0), CE(17:0), CE(17:1) ### Page 22 M42 62M43 9M44 11M45 39M46 8Cer(d18:1/16:0), Cer(d18:2/16:0), Cer1P(d18:1/16:0), Hex3Cer(d18:1/16:0), Hex3Cer(d18:1/18:0), Hex3Cer(d18:1/20:0), Hex3Cer(d18:1/22:0), Hex3Cer(d18:1/24:0), Hex3Cer(d18:1/24:1), GM3(d18:1/16:0), GM3(d18:1/18:0), GM3(d18:1/22:0), GM3(d18:1/24:0), GM3(d18:1/24:1), SHexCer(d18:1/16:0(OH)), SHexCer(d18:1/16:0), SHexCer(d18:1/24:1(OH)), SM(35:2) (b), SM(d18:0/16:0), SM(d18:1/16:0), PC(15-MHDA_18:2), PC(15:0_20:3), PC(16:0_16:0), PC(16:0_18:0), PC(16:0_18:2), PC(16:0_18:3) (a), PC(16:1_18:2), PC(17:0_18:2), PC(17:1_18:2), PC(18:0_18:2), PC(18:1_18:1), PC(18:1_18:2), PC(18:2_18:2), PC(33:2), PC(38:2), PC(38:6) (a), PC(40:8), PC(O-16:0/16:0), PC(O-16:0/20:3), PC(O-18:0/18:1), PC(O-18:0/18:2), PC(O-18:1/18:1), PC(O-18:1/18:2), PC(O-34:1), PC(O-34:2), PC(O-36:0), PC(P-16:0/16:0), PC(P-16:0/16:1), PC(P-16:0/18:0), PC(P-16:0/18:1), PC(P-16:0/18:2), PC(P-16:0/18:3), PC(P-18:0/18:2), PC(P-18:1/18:1), PC(P-35:2) (a), PC(P-35:2) (b), PC(P-36:3), PI(18:0_20:2), CE(16:0), CE(18:1), CE(18:2), COHPE(O-16:0/22:4), PE(P-16:0/22:4), PE(P-16:0/22:5) (n6), PE(P-18:0/22:4), PE(P-18:0/22:5) (n6), PE(P-18:1/22:4), PE(P-18:1/22:5) (b), CE(22:4), CE(22:5)Cer(d16:1/18:0), Cer(d16:1/20:0), Cer(d17:1/18:0), Cer(d17:1/20:0), Cer(d18:1/18:0), Cer(d18:1/19:0), Cer(d18:1/20:0), Cer(d18:1/21:0), Cer(d18:2/18:0), Cer(d18:2/20:0), Cer(d18:2/21:0)PC(15-MHDA_22:6), PC(15:0_22:6), PC(16:0_22:6), PC(16:1_22:6), PC(17:0_22:6), PC(18:0_22:6), PC(18:1_22:6) (a), PC(18:1_22:6) (b), PC(38:7) (c), PC(39:5) (a), PC(44:12), PC(O-16:0/22:6), PC(O-18:0/22:6), PC(P-16:0/22:6), PC(P-18:0/22:6), PC(P-18:1/22:6), LPC(22:6) [sn1], LPC(22:6) [sn2], PE(O-16:0/22:6), PE(O-18:0/22:6), PE(O-18:1/22:6), PE(O-38:5) (b), PE(P-15:0/22:6) (b), PE(P-16:0/22:6), PE(P-17:0/22:6) (a), PE(P-17:0/22:6) (b), PE(P-18:0/22:6), PE(P-18:1/22:6) (a), PE(P-18:1/22:6) (b), PE(P-20:0/22:6), PE(P-20:1/22:6), PI(18:0_22:5) (n3), PI(18:0_22:6), PI(37:6), PI(38:6), PI(39:6), CE(22:6), DE(22:6), CE(22:6) [+OH]SHexCer(d18:1/24:1), SM(43:2) (b), SM(43:2) (c), SM(44:2), SM(44:3), SM(d16:1/24:1), SM(d17:1/24:1), SM(d18:1/24:1) ### Page 23 Supplementary Table 5. Associations of lipid correlation network modules with baseline A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid modul Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)M39 0.122 0.053 0.192 0.001 0.026 0.053 -0.010 0.116 0.100 0.229 -0.037 -0.088 0.013 0.149 0.395 -0.110 -0.175 -0.045 0.001 0.042M34 0.112 0.043 0.180 0.001 0.033 0.079 0.018 0.141 0.011 0.102 -0.014 -0.060 0.033 0.559 0.857 -0.027 -0.092 0.037 0.403 0.530M3 0.104 0.033 0.174 0.004 0.047 0.048 -0.015 0.111 0.135 0.239 -0.009 -0.061 0.043 0.723 0.890 -0.065 -0.131 0.000 0.051 0.148M38 0.118 0.038 0.198 0.004 0.047 0.058 -0.012 0.129 0.104 0.229 -0.036 -0.088 0.017 0.181 0.438 -0.063 -0.137 0.011 0.097 0.235M37 -0.108 -0.188 -0.028 0.008 0.075 -0.049 -0.119 0.021 0.171 0.271 0.058 0.005 0.111 0.031 0.128 0.032 -0.042 0.106 0.396 0.530M8 -0.090 -0.160 -0.020 0.012 0.090 -0.059 -0.121 0.002 0.060 0.188 0.068 0.022 0.114 0.004 0.035 0.008 -0.056 0.072 0.808 0.909M19 0.089 0.015 0.163 0.018 0.121 0.024 -0.041 0.090 0.465 0.578 -0.016 -0.065 0.033 0.515 0.816 -0.018 -0.086 0.051 0.609 0.737M11 0.066 0.001 0.132 0.047 0.271 0.055 -0.004 0.113 0.068 0.196 -0.024 -0.068 0.020 0.279 0.569 -0.033 -0.094 0.028 0.286 0.454M4 0.070 -0.001 0.141 0.055 0.279 0.070 0.008 0.133 0.028 0.143 -0.059 -0.107 -0.012 0.015 0.069 -0.033 -0.099 0.032 0.318 0.488M36 0.083 -0.005 0.170 0.064 0.292 0.056 -0.024 0.137 0.169 0.271 -0.028 -0.094 0.039 0.412 0.702 -0.066 -0.150 0.018 0.121 0.266M9 -0.088 -0.188 0.012 0.085 0.292 -0.001 -0.088 0.087 0.984 0.984 0.103 0.036 0.171 0.003 0.032 0.069 -0.025 0.163 0.148 0.310M7 0.068 -0.008 0.144 0.081 0.292 -0.006 -0.074 0.062 0.859 0.919 0.028 -0.022 0.078 0.274 0.569 0.042 -0.027 0.111 0.236 0.402M32 0.071 -0.010 0.151 0.085 0.292 0.056 -0.016 0.127 0.125 0.239 -0.011 -0.065 0.043 0.682 0.871 -0.042 -0.115 0.032 0.270 0.443M33 -0.063 -0.136 0.010 0.089 0.292 -0.079 -0.143 -0.014 0.018 0.135 0.030 -0.019 0.078 0.232 0.533 0.008 -0.059 0.076 0.810 0.909M42 0.090 -0.022 0.203 0.115 0.352 0.083 -0.011 0.178 0.083 0.214 0.018 -0.064 0.100 0.666 0.871 -0.125 -0.223 -0.028 0.012 0.079M15 -0.056 -0.131 0.019 0.143 0.410 -0.008 -0.074 0.059 0.821 0.910 0.079 0.027 0.130 0.003 0.032 0.029 -0.039 0.098 0.402 0.530M16 -0.051 -0.123 0.020 0.157 0.412 -0.050 -0.114 0.014 0.125 0.239 0.119 0.070 0.169 0.000 0.000 0.017 -0.050 0.083 0.626 0.739M40 0.046 -0.018 0.109 0.161 0.412 0.055 -0.003 0.112 0.061 0.188 -0.016 -0.059 0.028 0.479 0.787 -0.001 -0.060 0.058 0.976 0.983M18 0.070 -0.040 0.181 0.211 0.477 0.112 0.017 0.207 0.021 0.135 -0.138 -0.205 -0.071 0.000 0.001 -0.100 -0.196 -0.005 0.039 0.139M10 -0.046 -0.116 0.025 0.202 0.477 0.001 -0.060 0.063 0.966 0.984 0.058 0.012 0.105 0.014 0.069 -0.004 -0.068 0.060 0.895 0.980M45 -0.049 -0.126 0.029 0.218 0.477 -0.105 -0.173 -0.038 0.002 0.053 0.069 0.017 0.121 0.009 0.054 0.002 -0.068 0.072 0.952 0.983M20 -0.039 -0.107 0.029 0.260 0.543 0.046 -0.014 0.105 0.135 0.239 0.007 -0.040 0.054 0.775 0.891 -0.045 -0.108 0.018 0.160 0.317M21 0.035 -0.040 0.109 0.361 0.554 0.113 0.047 0.178 0.001 0.036 -0.041 -0.094 0.011 0.123 0.378 -0.101 -0.170 -0.031 0.005 0.077M43 -0.037 -0.111 0.037 0.331 0.554 0.091 0.025 0.156 0.007 0.080 0.000 -0.054 0.054 0.996 0.996 -0.083 -0.152 -0.014 0.018 0.104M12 -0.036 -0.111 0.039 0.345 0.554 -0.032 -0.100 0.036 0.356 0.468 0.073 0.023 0.123 0.005 0.035 0.070 0.001 0.140 0.047 0.146M13 0.053 -0.046 0.151 0.293 0.554 0.023 -0.062 0.108 0.594 0.683 0.011 -0.053 0.075 0.741 0.890 -0.081 -0.170 0.009 0.077 0.197M27 -0.040 -0.125 0.046 0.361 0.554 -0.026 -0.100 0.048 0.490 0.593 0.003 -0.053 0.059 0.925 0.967 -0.038 -0.115 0.039 0.337 0.493M24 -0.037 -0.111 0.037 0.326 0.554 -0.066 -0.133 0.001 0.053 0.188 0.013 -0.037 0.062 0.616 0.864 0.022 -0.047 0.091 0.534 0.682M28 -0.034 -0.106 0.038 0.351 0.554 -0.002 -0.065 0.062 0.962 0.984 0.064 0.016 0.112 0.009 0.054 0.019 -0.049 0.087 0.583 0.725M22 -0.041 -0.122 0.040 0.324 0.554 -0.077 -0.150 -0.004 0.038 0.174 0.014 -0.041 0.069 0.620 0.864 -0.001 -0.076 0.074 0.983 0.983M14 0.032 -0.046 0.110 0.417 0.619 0.102 0.032 0.171 0.004 0.064 -0.012 -0.067 0.043 0.676 0.871 -0.077 -0.148 -0.005 0.036 0.136M5 -0.024 -0.091 0.043 0.487 0.700 -0.007 -0.067 0.054 0.831 0.910 -0.003 -0.048 0.041 0.886 0.948 -0.063 -0.125 -0.001 0.048 0.146M26 -0.020 -0.085 0.045 0.549 0.765 0.030 -0.028 0.089 0.309 0.431 -0.021 -0.065 0.023 0.339 0.624 -0.080 -0.141 -0.019 0.010 0.077M23 -0.023 -0.110 0.064 0.600 0.812 0.072 -0.002 0.146 0.057 0.188 0.005 -0.058 0.068 0.867 0.948 -0.102 -0.179 -0.024 0.010 0.077M29 -0.022 -0.113 0.068 0.628 0.826 0.038 -0.042 0.118 0.354 0.468 0.000 -0.063 0.062 0.990 0.996 -0.081 -0.166 0.004 0.061 0.166M31 0.019 -0.063 0.101 0.655 0.837 0.081 0.010 0.151 0.026 0.143 0.042 -0.015 0.100 0.150 0.395 -0.001 -0.077 0.074 0.971 0.983M41 0.015 -0.068 0.097 0.724 0.900 0.054 -0.019 0.127 0.144 0.246 -0.015 -0.070 0.041 0.604 0.864 -0.050 -0.126 0.026 0.196 0.347M44 0.012 -0.063 0.087 0.748 0.905 0.042 -0.025 0.109 0.219 0.324 -0.024 -0.074 0.027 0.362 0.641 -0.049 -0.119 0.020 0.165 0.317M35 -0.006 -0.086 0.074 0.887 0.913 0.055 -0.014 0.125 0.118 0.239 0.031 -0.026 0.087 0.284 0.569 -0.098 -0.170 -0.026 0.008 0.077M6 -0.010 -0.086 0.065 0.788 0.913 0.058 -0.008 0.124 0.084 0.214 -0.008 -0.060 0.044 0.755 0.890 -0.095 -0.165 -0.026 0.007 0.077M2 -0.009 -0.116 0.097 0.862 0.913 0.062 -0.034 0.159 0.204 0.313 -0.067 -0.142 0.008 0.081 0.294 -0.116 -0.218 -0.015 0.025 0.114M30 0.006 -0.080 0.092 0.890 0.913 0.079 0.003 0.155 0.042 0.174 -0.046 -0.105 0.013 0.123 0.378 -0.093 -0.173 -0.013 0.023 0.114M25 -0.006 -0.073 0.062 0.868 0.913 0.023 -0.037 0.084 0.451 0.576 -0.023 -0.068 0.022 0.319 0.612 -0.069 -0.132 -0.007 0.030 0.127M17 0.006 -0.062 0.075 0.855 0.913 0.017 -0.044 0.078 0.585 0.683 0.005 -0.041 0.051 0.832 0.934 -0.052 -0.115 0.011 0.106 0.244M1 -0.006 -0.093 0.081 0.893 0.913 0.066 -0.014 0.145 0.105 0.229 -0.044 -0.105 0.017 0.155 0.395 -0.057 -0.139 0.025 0.174 0.320M46 0.002 -0.086 0.089 0.968 0.968 -0.045 -0.121 0.032 0.251 0.361 0.050 -0.007 0.108 0.083 0.294 -0.039 -0.121 0.042 0.343 0.49395% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper) ### Page 24 Supplementary Table 6. Associations of lipid species with longitudinal A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid SpeciesBeta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)deDE(20:4) -0.002 -0.024 0.020 0.859 0.981 0.008 -0.006 0.023 0.255 0.506 -0.026 -0.037 -0.015 0.000 0.004 -0.048 -0.077 -0.019 0.001 0.018PI(38:5) (b) -0.017 -0.039 0.005 0.136 0.903 -0.009 -0.023 0.005 0.222 0.482 -0.024 -0.035 -0.013 0.000 0.005 -0.058 -0.084 -0.031 0.000 0.004PC(18:1_22:6) (b) -0.002 -0.024 0.021 0.890 0.981 -0.009 -0.023 0.005 0.231 0.488 -0.023 -0.034 -0.012 0.000 0.008 -0.067 -0.094 -0.040 0.000 0.001deDE(18:2) 0.000 -0.022 0.023 0.975 0.995 -0.007 -0.021 0.007 0.314 0.557 -0.022 -0.032 -0.011 0.000 0.013 -0.049 -0.077 -0.022 0.000 0.010GM3(d18:1/22:0) 0.000 -0.022 0.021 0.976 0.995 -0.007 -0.021 0.007 0.336 0.574 -0.021 -0.032 -0.011 0.000 0.018 -0.056 -0.083 -0.028 0.000 0.005AC(18:2) -0.008 -0.030 0.014 0.496 0.922 -0.007 -0.021 0.007 0.315 0.557 -0.021 -0.031 -0.010 0.000 0.020 -0.026 -0.053 0.001 0.064 0.184LPC(O-24:2) -0.013 -0.035 0.009 0.262 0.903 -0.016 -0.030 -0.003 0.020 0.273 -0.020 -0.031 -0.009 0.000 0.022 -0.036 -0.063 -0.008 0.012 0.066LPC(O-22:1) -0.004 -0.026 0.018 0.693 0.964 -0.022 -0.036 -0.008 0.002 0.259 -0.020 -0.031 -0.009 0.000 0.022 -0.044 -0.071 -0.017 0.002 0.022GM3(d18:1/16:0) -0.001 -0.023 0.021 0.949 0.995 -0.007 -0.021 0.008 0.352 0.592 -0.020 -0.031 -0.009 0.000 0.022 -0.057 -0.084 -0.030 0.000 0.004GM3(d18:1/20:0) -0.007 -0.029 0.015 0.527 0.922 -0.009 -0.023 0.006 0.240 0.495 -0.020 -0.031 -0.009 0.000 0.030 -0.052 -0.080 -0.024 0.000 0.008LPC(O-20:1) -0.004 -0.026 0.018 0.716 0.964 -0.019 -0.033 -0.005 0.007 0.259 -0.019 -0.030 -0.009 0.000 0.030 -0.039 -0.066 -0.011 0.006 0.047AC(18:1) 0.002 -0.020 0.024 0.841 0.981 -0.016 -0.030 -0.002 0.024 0.285 -0.019 -0.030 -0.008 0.001 0.030 -0.051 -0.078 -0.024 0.000 0.008Hex2Cer(d18:1/20:0) 0.002 -0.020 0.024 0.858 0.981 0.007 -0.007 0.021 0.332 0.572 -0.019 -0.030 -0.008 0.001 0.030 -0.038 -0.066 -0.010 0.007 0.049LPC(O-24:1) -0.011 -0.033 0.011 0.330 0.922 -0.026 -0.040 -0.013 0.000 0.092 -0.018 -0.029 -0.008 0.001 0.043 -0.043 -0.070 -0.016 0.002 0.025HexCer(d18:1/20:0) 0.006 -0.016 0.028 0.575 0.933 -0.012 -0.026 0.002 0.093 0.359 -0.018 -0.029 -0.008 0.001 0.043 -0.040 -0.068 -0.013 0.004 0.042PE(P-15:0/22:6) (b) -0.005 -0.028 0.017 0.647 0.960 0.001 -0.013 0.015 0.881 0.934 0.018 0.007 0.029 0.001 0.051 0.008 -0.019 0.036 0.551 0.730SM(d18:2/18:1) -0.003 -0.025 0.019 0.766 0.969 0.001 -0.013 0.015 0.915 0.951 -0.018 -0.029 -0.007 0.001 0.059 -0.055 -0.081 -0.028 0.000 0.005PE(P-15:0/22:6) (a) -0.001 -0.024 0.022 0.929 0.995 -0.006 -0.019 0.008 0.429 0.661 0.017 0.006 0.028 0.002 0.076 0.012 -0.015 0.039 0.396 0.611LPC(18:1) [sn1] -0.006 -0.028 0.016 0.574 0.933 -0.016 -0.029 -0.002 0.026 0.285 -0.017 -0.028 -0.006 0.002 0.081 -0.037 -0.065 -0.010 0.007 0.049LPC(18:1) [sn2] -0.004 -0.026 0.018 0.724 0.964 -0.017 -0.031 -0.004 0.012 0.273 -0.017 -0.028 -0.006 0.002 0.081 -0.041 -0.068 -0.014 0.003 0.037LPC(O-18:0) -0.012 -0.034 0.010 0.275 0.903 -0.011 -0.025 0.003 0.125 0.385 -0.017 -0.027 -0.006 0.002 0.083 -0.036 -0.063 -0.008 0.011 0.063AC(20:4) -0.009 -0.031 0.013 0.444 0.922 -0.009 -0.022 0.005 0.193 0.454 -0.017 -0.027 -0.006 0.002 0.083 -0.027 -0.054 -0.001 0.046 0.155GM3(d18:1/24:1) -0.015 -0.037 0.007 0.185 0.903 -0.021 -0.036 -0.007 0.003 0.259 -0.017 -0.027 -0.006 0.003 0.084 -0.058 -0.086 -0.031 0.000 0.004LPC(20:2) [sn1] -0.012 -0.034 0.010 0.281 0.903 -0.011 -0.025 0.003 0.111 0.380 -0.016 -0.027 -0.006 0.003 0.084 -0.021 -0.048 0.005 0.118 0.293Hex3Cer(d18:1/16:0) -0.006 -0.028 0.016 0.574 0.933 -0.012 -0.026 0.002 0.107 0.375 -0.017 -0.027 -0.006 0.003 0.084 -0.060 -0.086 -0.033 0.000 0.004AC(18:3) 0.002 -0.020 0.024 0.842 0.981 -0.002 -0.016 0.012 0.792 0.891 -0.016 -0.027 -0.006 0.003 0.084 -0.018 -0.045 0.010 0.205 0.416PI(16:0_20:3) (a) -0.019 -0.041 0.003 0.089 0.903 -0.008 -0.022 0.006 0.279 0.524 -0.016 -0.027 -0.005 0.003 0.090 -0.035 -0.062 -0.008 0.010 0.061LPC(P-20:0) -0.009 -0.031 0.013 0.444 0.922 -0.008 -0.022 0.006 0.282 0.527 -0.016 -0.027 -0.005 0.003 0.090 -0.026 -0.053 0.001 0.063 0.184LPC(O-20:0) -0.010 -0.032 0.012 0.374 0.922 -0.017 -0.031 -0.003 0.016 0.273 -0.016 -0.027 -0.005 0.004 0.092 -0.038 -0.066 -0.011 0.007 0.048AC(20:3) (a) -0.017 -0.038 0.005 0.139 0.903 -0.014 -0.028 -0.001 0.035 0.298 -0.016 -0.027 -0.005 0.004 0.097 -0.026 -0.053 0.001 0.061 0.183HexCer(d18:1/18:0) -0.011 -0.034 0.011 0.317 0.922 -0.012 -0.026 0.002 0.081 0.356 -0.016 -0.026 -0.005 0.004 0.097 -0.056 -0.083 -0.028 0.000 0.005PI(18:1_18:2) 0.000 -0.022 0.022 0.973 0.995 0.006 -0.008 0.019 0.435 0.666 -0.016 -0.027 -0.005 0.004 0.097 -0.013 -0.040 0.014 0.353 0.572AC(20:3) (b) -0.010 -0.032 0.012 0.360 0.922 -0.016 -0.029 -0.003 0.018 0.273 -0.015 -0.026 -0.004 0.006 0.119 -0.041 -0.066 -0.015 0.002 0.025Cer(d18:2/20:0) -0.009 -0.031 0.013 0.405 0.922 -0.012 -0.026 0.002 0.092 0.356 -0.015 -0.026 -0.004 0.006 0.119 -0.043 -0.071 -0.016 0.002 0.026GM3(d18:1/24:0) 0.007 -0.015 0.029 0.528 0.922 -0.001 -0.015 0.013 0.867 0.932 -0.015 -0.026 -0.004 0.006 0.119 -0.039 -0.067 -0.012 0.005 0.045LPC(20:1) [sn1] 0.007 -0.015 0.029 0.536 0.923 -0.011 -0.025 0.003 0.137 0.401 -0.015 -0.026 -0.004 0.006 0.119 -0.025 -0.052 0.003 0.079 0.217AC(18:0) -0.006 -0.028 0.016 0.616 0.950 -0.020 -0.034 -0.007 0.004 0.259 -0.015 -0.026 -0.005 0.005 0.119 -0.054 -0.081 -0.027 0.000 0.005LPC(O-18:1) -0.004 -0.025 0.018 0.744 0.964 -0.012 -0.026 0.002 0.084 0.356 -0.015 -0.026 -0.004 0.006 0.119 -0.026 -0.053 0.001 0.057 0.173GM1(d18:1/16:0) 0.003 -0.020 0.025 0.823 0.980 -0.018 -0.032 -0.003 0.015 0.273 -0.015 -0.026 -0.005 0.005 0.119 -0.060 -0.089 -0.032 0.000 0.004LPC(P-18:1) -0.007 -0.029 0.015 0.526 0.922 -0.012 -0.025 0.002 0.099 0.366 -0.015 -0.026 -0.004 0.007 0.120 -0.024 -0.051 0.003 0.081 0.221LPC(19:1) (b) -0.006 -0.028 0.016 0.597 0.950 -0.010 -0.024 0.003 0.141 0.406 -0.015 -0.026 -0.004 0.006 0.120 -0.040 -0.068 -0.013 0.004 0.041DE(18:1) 0.001 -0.021 0.023 0.935 0.995 -0.003 -0.016 0.011 0.717 0.855 -0.015 -0.026 -0.004 0.007 0.120 -0.040 -0.068 -0.012 0.006 0.047SM(40:3) (b) -0.013 -0.036 0.009 0.234 0.903 -0.009 -0.023 0.005 0.216 0.477 -0.015 -0.026 -0.004 0.007 0.127 -0.054 -0.081 -0.028 0.000 0.005PE(P-15:0/20:4) (b) -0.012 -0.034 0.010 0.293 0.903 -0.005 -0.019 0.008 0.458 0.682 0.014 0.004 0.025 0.008 0.127 0.009 -0.018 0.036 0.524 0.714PE(18:1_22:6) (b) -0.008 -0.030 0.014 0.484 0.922 -0.013 -0.027 0.001 0.071 0.349 -0.015 -0.026 -0.004 0.008 0.127 -0.036 -0.063 -0.008 0.012 0.066SM(d18:0/22:0) 0.009 -0.013 0.031 0.424 0.922 0.011 -0.003 0.025 0.122 0.385 0.015 0.004 0.025 0.008 0.127 0.008 -0.019 0.036 0.566 0.742PE(16:0_20:3) -0.014 -0.036 0.008 0.199 0.903 -0.015 -0.029 -0.001 0.031 0.291 -0.015 -0.025 -0.004 0.008 0.128 -0.026 -0.054 0.001 0.063 0.184Hex3Cer(d18:1/20:0) -0.003 -0.025 0.019 0.778 0.973 -0.008 -0.022 0.006 0.263 0.514 -0.015 -0.025 -0.004 0.008 0.128 -0.046 -0.073 -0.018 0.001 0.019PC(18:1_22:6) (a) 0.011 -0.011 0.033 0.337 0.922 -0.013 -0.027 0.001 0.060 0.327 -0.014 -0.025 -0.004 0.009 0.139 -0.045 -0.072 -0.018 0.001 0.02095% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper) ### Page 25 TG(52:4) [NL-16:1] -0.011 -0.033 0.011 0.324 0.922 -0.016 -0.030 -0.002 0.021 0.273 -0.014 -0.025 -0.003 0.010 0.139 -0.044 -0.071 -0.016 0.002 0.025LPC(O-22:0) -0.005 -0.028 0.017 0.629 0.954 -0.015 -0.029 -0.001 0.040 0.305 -0.014 -0.025 -0.004 0.009 0.139 -0.033 -0.061 -0.005 0.020 0.092SM(35:2) (b) -0.005 -0.027 0.017 0.660 0.960 -0.006 -0.020 0.008 0.413 0.646 -0.014 -0.025 -0.004 0.009 0.139 -0.051 -0.078 -0.025 0.000 0.006AC(16:1) 0.000 -0.022 0.022 0.986 0.996 -0.011 -0.025 0.002 0.108 0.377 -0.014 -0.025 -0.003 0.010 0.146 -0.046 -0.074 -0.019 0.001 0.017TG(O-50:1) [NL-18:1] -0.010 -0.032 0.011 0.351 0.922 -0.003 -0.016 0.011 0.703 0.846 0.014 0.003 0.025 0.011 0.150 0.028 0.000 0.056 0.047 0.156LPE(18:2) [sn2] -0.024 -0.046 -0.002 0.030 0.903 -0.012 -0.026 0.002 0.087 0.356 -0.014 -0.025 -0.003 0.012 0.156 -0.021 -0.049 0.006 0.134 0.320TG(O-54:2) [NL-17:1] -0.017 -0.039 0.006 0.146 0.903 -0.008 -0.022 0.005 0.218 0.477 0.014 0.003 0.025 0.012 0.156 0.016 -0.011 0.043 0.242 0.456PC(O-18:0/18:2) -0.011 -0.033 0.011 0.326 0.922 -0.008 -0.022 0.006 0.246 0.501 -0.014 -0.025 -0.003 0.012 0.156 -0.037 -0.064 -0.010 0.007 0.049PC(38:5) (a) -0.004 -0.026 0.018 0.715 0.964 -0.005 -0.019 0.008 0.439 0.667 -0.014 -0.024 -0.003 0.012 0.156 -0.056 -0.083 -0.028 0.000 0.005Cer(d18:1/20:0) -0.021 -0.043 0.000 0.054 0.903 -0.014 -0.028 0.000 0.053 0.317 -0.014 -0.024 -0.003 0.013 0.166 -0.039 -0.066 -0.011 0.006 0.048LPC(20:0) [sn1] 0.013 -0.009 0.034 0.261 0.903 -0.003 -0.018 0.011 0.633 0.803 -0.014 -0.024 -0.003 0.014 0.167 -0.010 -0.038 0.018 0.472 0.665PS(36:2) -0.010 -0.032 0.012 0.379 0.922 -0.016 -0.030 -0.002 0.024 0.285 -0.014 -0.024 -0.003 0.014 0.167 -0.018 -0.045 0.009 0.197 0.409PC(38:7) (c) -0.004 -0.026 0.018 0.725 0.964 -0.013 -0.027 0.001 0.073 0.350 -0.014 -0.025 -0.003 0.014 0.167 -0.051 -0.079 -0.024 0.000 0.008CE(16:2) 0.004 -0.018 0.026 0.739 0.964 -0.003 -0.016 0.011 0.712 0.853 -0.013 -0.024 -0.003 0.014 0.167 -0.032 -0.058 -0.005 0.021 0.093LPE(18:2) [sn1] -0.021 -0.042 0.001 0.066 0.903 -0.011 -0.024 0.003 0.122 0.385 -0.014 -0.024 -0.003 0.015 0.169 -0.026 -0.054 0.001 0.064 0.184PE(P-15:0/20:4) (a) -0.020 -0.043 0.002 0.074 0.903 -0.009 -0.023 0.005 0.201 0.463 0.013 0.003 0.024 0.015 0.169 0.008 -0.018 0.035 0.548 0.729Hex2Cer(d18:1/16:0) -0.006 -0.028 0.016 0.613 0.950 -0.005 -0.019 0.009 0.471 0.689 -0.013 -0.024 -0.003 0.015 0.169 -0.049 -0.075 -0.022 0.000 0.010PC(18:1_18:2) 0.002 -0.020 0.024 0.884 0.981 -0.008 -0.022 0.005 0.232 0.488 -0.013 -0.024 -0.003 0.015 0.169 -0.025 -0.052 0.002 0.072 0.201PC(O-35:4) -0.019 -0.040 0.003 0.092 0.903 -0.002 -0.016 0.012 0.769 0.881 0.013 0.003 0.024 0.015 0.170 0.007 -0.020 0.034 0.625 0.790LPC(20:1) [sn2] 0.015 -0.007 0.037 0.177 0.903 -0.005 -0.019 0.009 0.513 0.724 -0.013 -0.024 -0.002 0.016 0.171 -0.026 -0.054 0.001 0.060 0.179CE(22:5) -0.003 -0.025 0.019 0.780 0.973 0.003 -0.011 0.016 0.700 0.846 -0.013 -0.024 -0.002 0.016 0.171 -0.038 -0.065 -0.011 0.006 0.047PE(P-17:0/22:6) (a) -0.007 -0.029 0.016 0.568 0.933 -0.009 -0.023 0.005 0.216 0.477 0.013 0.002 0.024 0.017 0.174 0.011 -0.017 0.038 0.446 0.652dhCer(d18:0/24:0) 0.000 -0.022 0.023 0.965 0.995 0.009 -0.005 0.023 0.227 0.488 0.013 0.002 0.024 0.016 0.174 0.014 -0.014 0.041 0.326 0.544Hex2Cer(d18:1/22:0) 0.004 -0.018 0.026 0.747 0.964 0.004 -0.010 0.018 0.622 0.792 -0.013 -0.024 -0.002 0.018 0.181 -0.027 -0.054 0.000 0.051 0.168SM(34:3) -0.003 -0.025 0.020 0.817 0.980 -0.001 -0.015 0.013 0.842 0.925 -0.013 -0.024 -0.002 0.018 0.181 -0.050 -0.076 -0.023 0.000 0.008Cer(d18:2/21:0) -0.003 -0.025 0.019 0.810 0.980 -0.009 -0.022 0.005 0.197 0.458 -0.013 -0.024 -0.002 0.018 0.181 -0.040 -0.068 -0.012 0.006 0.047Hex3Cer(d18:1/18:0) -0.009 -0.031 0.012 0.397 0.922 -0.007 -0.021 0.006 0.296 0.540 -0.013 -0.024 -0.002 0.019 0.186 -0.044 -0.071 -0.017 0.002 0.022DE(18:2) 0.009 -0.013 0.032 0.400 0.922 0.010 -0.003 0.024 0.126 0.385 -0.013 -0.023 -0.002 0.019 0.186 -0.006 -0.034 0.022 0.676 0.824Hex2Cer(d18:2/16:0) -0.006 -0.028 0.016 0.602 0.950 0.003 -0.011 0.017 0.687 0.840 -0.013 -0.024 -0.002 0.019 0.186 -0.024 -0.051 0.004 0.093 0.244PE(P-17:0/20:4) (a) -0.006 -0.028 0.017 0.624 0.954 -0.004 -0.018 0.010 0.584 0.763 0.013 0.002 0.023 0.020 0.186 0.011 -0.016 0.038 0.428 0.638LPC(16:1) [sn1] -0.018 -0.040 0.004 0.109 0.903 -0.012 -0.026 0.001 0.081 0.356 -0.013 -0.023 -0.002 0.020 0.186 -0.038 -0.064 -0.011 0.006 0.047HexCer(d16:1/20:0) -0.002 -0.024 0.020 0.862 0.981 -0.013 -0.027 0.000 0.056 0.317 -0.013 -0.023 -0.002 0.020 0.186 -0.032 -0.059 -0.004 0.024 0.105Cer(d18:1/16:0) -0.013 -0.035 0.009 0.235 0.903 -0.013 -0.027 0.001 0.066 0.338 -0.013 -0.024 -0.002 0.020 0.186 -0.039 -0.067 -0.012 0.005 0.046CE(22:4) -0.009 -0.031 0.013 0.411 0.922 0.000 -0.013 0.014 0.957 0.976 -0.013 -0.023 -0.002 0.021 0.192 -0.038 -0.065 -0.011 0.006 0.048PC(16:0_18:3) (a) -0.014 -0.036 0.008 0.211 0.903 -0.007 -0.022 0.007 0.317 0.557 -0.013 -0.023 -0.002 0.023 0.193 -0.029 -0.056 -0.002 0.036 0.134LPC(20:2) [sn2] -0.013 -0.035 0.009 0.237 0.903 -0.012 -0.026 0.002 0.085 0.356 -0.013 -0.023 -0.002 0.023 0.193 -0.015 -0.042 0.012 0.276 0.500-0.009 -0.031 0.013 0.403 0.922 -0.014 -0.027 0.000 0.052 0.317 -0.012 -0.023 -0.002 0.022 0.193 -0.040 -0.068 -0.013 0.004 0.043PE(P-16:0/20:4) -0.005 -0.027 0.017 0.657 0.960 0.009 -0.005 0.024 0.198 0.460 0.013 0.002 0.023 0.022 0.193 -0.002 -0.030 0.026 0.879 0.948CE(18:2) -0.003 -0.026 0.019 0.756 0.969 -0.004 -0.018 0.010 0.537 0.740 -0.013 -0.023 -0.002 0.022 0.193 -0.047 -0.075 -0.019 0.001 0.017PE(P-19:0/20:4) (a) -0.010 -0.032 0.012 0.363 0.922 -0.007 -0.020 0.007 0.355 0.595 0.012 0.002 0.023 0.023 0.194 0.011 -0.016 0.038 0.422 0.635LPC(P-18:0) -0.008 -0.030 0.014 0.481 0.922 -0.010 -0.024 0.004 0.159 0.432 -0.012 -0.023 -0.002 0.024 0.195 -0.029 -0.056 -0.001 0.040 0.144PC(P-15:0/20:4) (b) -0.004 -0.026 0.018 0.716 0.964 -0.003 -0.017 0.011 0.689 0.840 0.012 0.002 0.023 0.023 0.195 0.018 -0.010 0.045 0.206 0.417CE(20:2) -0.014 -0.036 0.008 0.205 0.903 -0.002 -0.016 0.012 0.780 0.884 -0.012 -0.023 -0.002 0.024 0.197 -0.032 -0.059 -0.005 0.019 0.089SM(41:0) 0.016 -0.005 0.038 0.141 0.903 0.000 -0.014 0.014 0.985 0.989 0.012 0.002 0.023 0.025 0.198 -0.002 -0.029 0.025 0.883 0.948HexCer(d18:2/22:0) 0.012 -0.010 0.034 0.273 0.903 0.006 -0.008 0.019 0.437 0.667 -0.012 -0.023 -0.002 0.025 0.201 -0.013 -0.040 0.015 0.370 0.590SM(d18:2/20:0) -0.003 -0.025 0.019 0.782 0.973 -0.001 -0.015 0.013 0.854 0.929 -0.012 -0.023 -0.001 0.026 0.201 -0.055 -0.082 -0.028 0.000 0.005AC(14:2) 0.003 -0.019 0.025 0.791 0.973 0.000 -0.014 0.013 0.946 0.972 -0.012 -0.023 -0.001 0.026 0.201 -0.035 -0.063 -0.007 0.015 0.076LPC(19:0) [sn1] (b) -0.001 -0.023 0.021 0.901 0.985 -0.013 -0.027 0.000 0.057 0.317 -0.012 -0.023 -0.001 0.026 0.201 -0.019 -0.047 0.008 0.169 0.373PA(36:2) -0.006 -0.028 0.017 0.625 0.954 -0.007 -0.021 0.007 0.302 0.546 -0.012 -0.023 -0.001 0.027 0.206 0.001 -0.027 0.029 0.933 0.964TG(54:4) [NL-18:2] 0.005 -0.016 0.027 0.623 0.954 -0.008 -0.022 0.006 0.280 0.524 -0.012 -0.023 -0.001 0.028 0.212 -0.020 -0.047 0.008 0.159 0.359PE(P-19:0/20:4) (b) -0.008 -0.030 0.015 0.493 0.922 -0.001 -0.015 0.013 0.919 0.953 0.012 0.001 0.023 0.030 0.223 0.006 -0.021 0.034 0.664 0.815PE(P-17:0/20:4) (b) -0.009 -0.031 0.013 0.413 0.922 0.002 -0.012 0.016 0.751 0.877 0.012 0.001 0.023 0.030 0.225 -0.007 -0.034 0.021 0.632 0.794PE(P-18:1/22:4) -0.012 -0.034 0.010 0.271 0.903 -0.002 -0.016 0.012 0.781 0.884 -0.012 -0.023 -0.001 0.031 0.226 -0.037 -0.063 -0.010 0.006 0.048PE(P-16:0/18:1) -0.006 -0.028 0.016 0.594 0.950 -0.004 -0.018 0.011 0.624 0.793 0.012 0.001 0.023 0.031 0.226 -0.006 -0.034 0.021 0.660 0.814LPC(22:5) [sn1] (n3) & LPC(22:5) [sn2] (n6) ### Page 26 LPC(20:0) [sn2] 0.016 -0.006 0.038 0.162 0.903 -0.001 -0.015 0.013 0.890 0.939 -0.012 -0.022 -0.001 0.034 0.242 -0.009 -0.036 0.019 0.541 0.725TG(O-50:1) [NL-15:0] -0.011 -0.033 0.010 0.309 0.907 -0.003 -0.016 0.011 0.703 0.846 0.012 0.001 0.022 0.034 0.242 0.013 -0.015 0.040 0.359 0.577SM(38:3) (a) -0.010 -0.032 0.012 0.369 0.922 -0.004 -0.018 0.010 0.607 0.777 -0.012 -0.022 -0.001 0.035 0.244 -0.051 -0.077 -0.024 0.000 0.008SM(38:3) (b) -0.012 -0.034 0.010 0.299 0.903 -0.012 -0.026 0.002 0.090 0.356 -0.012 -0.022 -0.001 0.037 0.253 -0.049 -0.075 -0.023 0.000 0.008Cer(d18:1/21:0) -0.014 -0.036 0.008 0.225 0.903 -0.008 -0.022 0.006 0.258 0.509 -0.012 -0.022 -0.001 0.036 0.253 -0.046 -0.073 -0.018 0.001 0.018LPC(17:0) [sn1] -0.004 -0.026 0.018 0.709 0.964 -0.013 -0.027 0.001 0.064 0.338 -0.011 -0.022 -0.001 0.037 0.253 -0.033 -0.061 -0.006 0.017 0.085Cer(d18:2/24:1) -0.007 -0.029 0.015 0.517 0.922 -0.017 -0.031 -0.004 0.014 0.273 -0.012 -0.022 -0.001 0.037 0.253 -0.031 -0.059 -0.004 0.027 0.110AC(12:1) -0.005 -0.027 0.017 0.675 0.964 -0.005 -0.018 0.009 0.501 0.719 -0.011 -0.022 -0.001 0.038 0.253 -0.048 -0.076 -0.020 0.001 0.014PE(38:5) (a) -0.013 -0.035 0.009 0.259 0.903 -0.014 -0.028 0.000 0.054 0.317 -0.011 -0.022 -0.001 0.038 0.255 -0.034 -0.062 -0.006 0.018 0.087TG(54:5) [NL-18:3] -0.005 -0.027 0.017 0.643 0.960 -0.012 -0.026 0.001 0.081 0.356 -0.011 -0.022 -0.001 0.040 0.266 -0.012 -0.039 0.015 0.392 0.609GM3(d18:1/18:0) -0.018 -0.040 0.004 0.114 0.903 -0.009 -0.022 0.005 0.225 0.486 -0.011 -0.022 0.000 0.042 0.267 -0.056 -0.083 -0.028 0.000 0.005LPE(16:0) [sn2] -0.017 -0.039 0.005 0.125 0.903 -0.017 -0.030 -0.003 0.014 0.273 -0.011 -0.022 0.000 0.041 0.267 -0.031 -0.058 -0.004 0.025 0.106PI(38:5) (a) -0.016 -0.038 0.006 0.155 0.903 -0.006 -0.019 0.008 0.431 0.663 -0.011 -0.022 0.000 0.043 0.267 -0.027 -0.055 0.000 0.053 0.170TG(O-50:1) [NL-16:0] -0.013 -0.035 0.008 0.228 0.903 -0.006 -0.019 0.008 0.419 0.650 0.011 0.000 0.022 0.042 0.267 0.018 -0.010 0.046 0.211 0.420PC(O-40:5) -0.008 -0.031 0.014 0.456 0.922 -0.009 -0.023 0.005 0.218 0.477 -0.011 -0.022 0.000 0.042 0.267 -0.052 -0.079 -0.026 0.000 0.006LPE(P-20:0) 0.005 -0.017 0.027 0.629 0.954 -0.013 -0.027 0.001 0.062 0.333 -0.011 -0.022 0.000 0.041 0.267 -0.023 -0.051 0.005 0.107 0.272PC(18:1_18:1) -0.004 -0.026 0.018 0.706 0.964 -0.018 -0.032 -0.004 0.013 0.273 -0.011 -0.022 0.000 0.042 0.267 -0.032 -0.059 -0.005 0.020 0.092TG(O-52:1) [NL-18:1] -0.013 -0.035 0.008 0.225 0.903 -0.008 -0.022 0.005 0.239 0.495 0.011 0.000 0.022 0.043 0.268 0.018 -0.009 0.046 0.189 0.401PC(O-18:0/18:1) -0.012 -0.034 0.010 0.290 0.903 -0.012 -0.026 0.002 0.081 0.356 -0.011 -0.022 0.000 0.048 0.270 -0.051 -0.078 -0.024 0.000 0.008LPC(O-16:0) -0.012 -0.033 0.010 0.280 0.903 -0.010 -0.024 0.004 0.153 0.424 -0.011 -0.022 0.000 0.047 0.270 -0.021 -0.049 0.006 0.124 0.301HexCer(d18:1/22:0) 0.015 -0.007 0.037 0.184 0.903 0.001 -0.013 0.015 0.862 0.930 -0.011 -0.022 0.000 0.049 0.270 -0.020 -0.048 0.008 0.155 0.352LPC(16:0) [sn1] -0.014 -0.036 0.007 0.198 0.903 -0.017 -0.031 -0.003 0.014 0.273 -0.011 -0.022 0.000 0.051 0.270 -0.019 -0.046 0.008 0.168 0.373PC(O-34:4) -0.015 -0.037 0.007 0.183 0.903 -0.004 -0.018 0.010 0.616 0.787 0.011 0.000 0.021 0.048 0.270 0.010 -0.017 0.037 0.466 0.664LPC(18:3) [sn2] (a) -0.012 -0.034 0.010 0.295 0.903 -0.009 -0.023 0.005 0.220 0.479 -0.011 -0.022 0.000 0.047 0.270 -0.010 -0.037 0.018 0.481 0.675LPC(16:0) [sn2] -0.015 -0.037 0.007 0.175 0.903 -0.012 -0.026 0.002 0.089 0.356 -0.011 -0.022 0.000 0.047 0.270 -0.005 -0.032 0.022 0.698 0.842HexCer(d18:1/24:1) 0.008 -0.014 0.030 0.463 0.922 -0.015 -0.028 -0.001 0.034 0.298 -0.011 -0.022 0.000 0.047 0.270 -0.029 -0.057 -0.001 0.040 0.142TG(O-52:2) [NL-17:1] -0.008 -0.029 0.014 0.495 0.922 -0.005 -0.019 0.008 0.453 0.678 0.011 0.000 0.021 0.049 0.270 0.021 -0.007 0.048 0.141 0.330PE(P-16:0/20:5) 0.011 -0.011 0.033 0.336 0.922 -0.006 -0.020 0.008 0.416 0.649 0.011 0.000 0.022 0.047 0.270 0.001 -0.027 0.028 0.961 0.971LPC(22:5) (n3) [sn1] [104_sn1] -0.006 -0.028 0.016 0.617 0.950 -0.015 -0.029 -0.001 0.032 0.298 -0.011 -0.022 0.000 0.048 0.270 -0.039 -0.067 -0.011 0.006 0.048LPC(22:5) [sn2] (n3) -0.005 -0.027 0.017 0.657 0.960 -0.014 -0.028 -0.001 0.042 0.306 -0.011 -0.021 0.000 0.051 0.270 -0.037 -0.065 -0.010 0.008 0.050TG(54:6) [NL-22:6] -0.005 -0.027 0.017 0.652 0.960 -0.011 -0.025 0.003 0.119 0.385 0.011 0.000 0.022 0.051 0.270 0.013 -0.015 0.041 0.366 0.586DG(18:1_22:6) 0.004 -0.018 0.026 0.735 0.964 -0.012 -0.026 0.002 0.086 0.356 0.011 0.000 0.022 0.049 0.270 0.009 -0.019 0.038 0.508 0.702TG(56:7) [NL-22:6] 0.005 -0.017 0.027 0.668 0.964 -0.014 -0.028 0.000 0.051 0.317 0.011 0.000 0.022 0.047 0.270 0.007 -0.021 0.035 0.640 0.801PE(P-18:1/20:4) (a) -0.003 -0.025 0.019 0.794 0.974 0.008 -0.006 0.022 0.272 0.521 0.011 0.000 0.022 0.046 0.270 -0.003 -0.031 0.025 0.826 0.923AC(24:1) 0.002 -0.020 0.024 0.848 0.981 -0.010 -0.024 0.004 0.172 0.438 -0.011 -0.022 0.000 0.049 0.270 -0.020 -0.047 0.006 0.135 0.320LPC(18:2) [+OH] 0.001 -0.021 0.024 0.898 0.983 -0.010 -0.024 0.004 0.163 0.432 -0.011 -0.022 0.000 0.051 0.270 -0.002 -0.030 0.026 0.900 0.952Hex2Cer(d18:1/24:0) 0.001 -0.021 0.023 0.913 0.987 0.000 -0.013 0.014 0.956 0.976 -0.011 -0.022 0.000 0.044 0.270 -0.021 -0.048 0.007 0.142 0.330LPE(P-18:1) -0.001 -0.022 0.021 0.962 0.995 -0.001 -0.016 0.013 0.856 0.929 -0.011 -0.021 0.000 0.051 0.270 -0.031 -0.058 -0.004 0.026 0.107PE(O-36:5) 0.001 -0.022 0.023 0.964 0.995 -0.009 -0.023 0.005 0.212 0.475 0.011 0.000 0.021 0.051 0.270 0.004 -0.024 0.031 0.793 0.904TG(52:4) [NL-18:2] -0.012 -0.034 0.010 0.276 0.903 -0.007 -0.021 0.007 0.301 0.546 -0.011 -0.021 0.000 0.053 0.274 -0.023 -0.050 0.005 0.108 0.274LPC(18:0) [sn1] -0.005 -0.027 0.017 0.649 0.960 -0.009 -0.023 0.004 0.180 0.450 -0.011 -0.021 0.000 0.052 0.274 -0.027 -0.054 0.001 0.056 0.173PC(16:1_18:2) -0.013 -0.035 0.009 0.253 0.903 -0.008 -0.022 0.006 0.267 0.520 -0.011 -0.021 0.000 0.053 0.275 -0.032 -0.059 -0.006 0.018 0.086dhCer(d18:0/20:0) -0.007 -0.029 0.015 0.543 0.929 0.001 -0.013 0.014 0.938 0.969 0.011 0.000 0.021 0.054 0.278 -0.002 -0.030 0.025 0.881 0.948AC(14:1) 0.005 -0.017 0.027 0.629 0.954 -0.006 -0.020 0.007 0.358 0.598 -0.011 -0.021 0.000 0.055 0.280 -0.046 -0.073 -0.018 0.001 0.020HexCer(d18:2/18:0) 0.002 -0.020 0.024 0.861 0.981 -0.017 -0.031 -0.003 0.017 0.273 -0.011 -0.021 0.000 0.056 0.282 -0.034 -0.062 -0.006 0.017 0.084PE(P-16:0/22:6) 0.002 -0.021 0.024 0.882 0.981 0.000 -0.014 0.015 0.962 0.979 0.011 0.000 0.021 0.056 0.283 0.002 -0.026 0.030 0.878 0.948Cer(d18:2/22:0) -0.004 -0.026 0.018 0.730 0.964 -0.003 -0.017 0.012 0.698 0.845 -0.011 -0.021 0.000 0.057 0.284 -0.016 -0.044 0.012 0.259 0.477dhCer(d18:0/22:0) 0.001 -0.021 0.023 0.914 0.987 0.009 -0.005 0.023 0.213 0.475 0.010 0.000 0.021 0.058 0.287 0.013 -0.014 0.040 0.358 0.577PE(P-18:1/20:5) (a) 0.013 -0.009 0.035 0.250 0.903 -0.008 -0.022 0.006 0.269 0.520 0.010 0.000 0.021 0.060 0.292 -0.009 -0.036 0.019 0.532 0.719PE(P-18:1/18:2) (b) -0.008 -0.030 0.014 0.474 0.922 0.001 -0.013 0.015 0.906 0.944 -0.010 -0.021 0.000 0.060 0.292 -0.034 -0.060 -0.007 0.014 0.072LPC(18:0) [sn2] -0.003 -0.025 0.019 0.781 0.973 -0.009 -0.022 0.005 0.226 0.487 -0.010 -0.021 0.000 0.061 0.292 -0.025 -0.052 0.003 0.077 0.215PC(P-16:0/22:6) -0.001 -0.023 0.022 0.961 0.995 -0.007 -0.021 0.007 0.340 0.578 0.010 0.000 0.021 0.060 0.292 -0.001 -0.029 0.026 0.924 0.964Cer1P(d18:1/16:0) -0.004 -0.025 0.018 0.747 0.964 -0.001 -0.015 0.013 0.898 0.942 -0.010 -0.021 0.000 0.061 0.293 -0.025 -0.053 0.003 0.078 0.216SM(44:3) -0.008 -0.030 0.015 0.500 0.922 -0.008 -0.022 0.006 0.256 0.507 -0.010 -0.021 0.000 0.062 0.294 -0.039 -0.066 -0.012 0.004 0.042TG(52:3) [NL-16:1] 0.003 -0.018 0.025 0.757 0.969 -0.019 -0.033 -0.006 0.006 0.259 -0.010 -0.021 0.001 0.062 0.294 -0.053 -0.080 -0.025 0.000 0.008 ### Page 27 AC(18:1)-OH 0.002 -0.020 0.024 0.878 0.981 -0.008 -0.022 0.005 0.240 0.495 -0.010 -0.021 0.001 0.063 0.294 -0.041 -0.068 -0.013 0.004 0.038PC(40:8) -0.002 -0.024 0.021 0.874 0.981 -0.009 -0.023 0.005 0.232 0.488 -0.010 -0.021 0.001 0.064 0.300 -0.026 -0.054 0.001 0.060 0.181LPE(18:1) [sn1] -0.013 -0.035 0.009 0.263 0.903 -0.015 -0.028 -0.001 0.038 0.301 -0.010 -0.021 0.001 0.067 0.309 -0.019 -0.047 0.008 0.174 0.378Hex3Cer(d18:1/22:0) 0.001 -0.021 0.023 0.948 0.995 -0.004 -0.018 0.010 0.607 0.777 -0.010 -0.021 0.001 0.067 0.309 -0.045 -0.072 -0.018 0.001 0.018Cer(d18:1/18:0) -0.026 -0.048 -0.005 0.017 0.903 -0.013 -0.027 0.000 0.056 0.317 -0.010 -0.021 0.001 0.068 0.310 -0.049 -0.076 -0.022 0.001 0.011PC(O-18:1/18:1) 0.000 -0.022 0.022 1.000 1.000 -0.011 -0.025 0.003 0.129 0.390 -0.010 -0.021 0.001 0.068 0.310 -0.036 -0.063 -0.009 0.009 0.056PE(P-18:0/20:4) -0.006 -0.028 0.016 0.568 0.933 0.006 -0.008 0.021 0.400 0.638 0.010 -0.001 0.021 0.069 0.312 -0.002 -0.030 0.026 0.887 0.948HexCer(d16:1/22:0) 0.009 -0.013 0.032 0.404 0.922 -0.009 -0.023 0.004 0.186 0.453 -0.010 -0.021 0.001 0.069 0.312 -0.011 -0.039 0.016 0.417 0.631AC(12:0) -0.002 -0.024 0.021 0.891 0.981 -0.007 -0.021 0.007 0.304 0.546 -0.010 -0.021 0.001 0.070 0.312 -0.050 -0.079 -0.022 0.000 0.010-0.003 -0.025 0.019 0.791 0.973 -0.015 -0.029 -0.001 0.037 0.301 -0.010 -0.021 0.001 0.071 0.317 -0.036 -0.063 -0.008 0.011 0.064LPE(18:0) [sn1] -0.018 -0.040 0.004 0.111 0.903 -0.012 -0.026 0.001 0.073 0.350 -0.010 -0.021 0.001 0.072 0.319 -0.021 -0.049 0.006 0.127 0.309PC(P-16:0/20:5) 0.008 -0.014 0.030 0.481 0.922 -0.009 -0.023 0.005 0.219 0.477 0.010 -0.001 0.021 0.073 0.319 0.003 -0.025 0.031 0.837 0.928S1P(d18:0) -0.005 -0.027 0.017 0.676 0.964 -0.010 -0.024 0.004 0.145 0.406 -0.010 -0.020 0.001 0.073 0.319 -0.022 -0.050 0.006 0.119 0.293PE(P-17:0/22:6) (b) -0.002 -0.024 0.021 0.879 0.981 -0.002 -0.017 0.012 0.749 0.877 0.010 -0.001 0.021 0.073 0.319 -0.003 -0.032 0.025 0.826 0.923PE(P-16:0/20:3) (a) -0.010 -0.033 0.012 0.356 0.922 -0.005 -0.019 0.009 0.465 0.686 0.010 -0.001 0.021 0.074 0.320 -0.014 -0.042 0.013 0.303 0.526AC(16:0) -0.014 -0.036 0.008 0.211 0.903 -0.015 -0.029 -0.002 0.030 0.289 -0.010 -0.020 0.001 0.075 0.323 -0.048 -0.075 -0.022 0.000 0.010PC(38:4) (b) -0.016 -0.037 0.006 0.157 0.903 -0.003 -0.017 0.011 0.640 0.807 -0.010 -0.021 0.001 0.076 0.323 -0.039 -0.066 -0.013 0.004 0.042LPC(22:4) [sn1] -0.011 -0.033 0.010 0.300 0.903 -0.004 -0.018 0.010 0.566 0.748 -0.010 -0.020 0.001 0.076 0.323 -0.018 -0.045 0.010 0.208 0.419AC(14:0) -0.003 -0.025 0.019 0.791 0.973 -0.013 -0.027 0.000 0.057 0.317 -0.010 -0.020 0.001 0.076 0.323 -0.046 -0.074 -0.019 0.001 0.017LPE(18:1) [sn2] -0.013 -0.035 0.009 0.263 0.903 -0.013 -0.027 0.000 0.055 0.317 -0.010 -0.021 0.001 0.077 0.324 -0.020 -0.048 0.007 0.149 0.340Cer(d18:2/16:0) -0.003 -0.025 0.019 0.770 0.973 -0.006 -0.021 0.008 0.368 0.603 -0.010 -0.021 0.001 0.078 0.325 -0.033 -0.061 -0.006 0.018 0.086TG(O-50:3) [NL-18:2] -0.030 -0.052 -0.009 0.006 0.903 0.010 -0.003 0.024 0.138 0.403 0.010 -0.001 0.020 0.078 0.326 0.020 -0.006 0.047 0.133 0.318Cer(d18:1/24:1) -0.020 -0.042 0.002 0.070 0.903 -0.019 -0.033 -0.006 0.006 0.259 -0.010 -0.020 0.001 0.079 0.328 -0.040 -0.067 -0.012 0.005 0.044LPC(22:0) [sn2] 0.012 -0.009 0.034 0.266 0.903 0.005 -0.009 0.018 0.521 0.727 -0.010 -0.020 0.001 0.080 0.328 0.004 -0.023 0.031 0.768 0.892Cer(d18:2/18:0) -0.015 -0.037 0.007 0.181 0.903 -0.010 -0.023 0.004 0.162 0.432 -0.010 -0.020 0.001 0.081 0.330 -0.044 -0.072 -0.017 0.002 0.023dxCA -0.013 -0.036 0.009 0.250 0.903 0.001 -0.013 0.014 0.941 0.971 -0.010 -0.021 0.001 0.082 0.333 -0.015 -0.042 0.012 0.279 0.503PE(18:1_18:2) -0.005 -0.027 0.017 0.649 0.960 -0.012 -0.026 0.001 0.080 0.356 -0.010 -0.020 0.001 0.083 0.337 -0.005 -0.033 0.023 0.728 0.863PE(P-18:0/22:6) 0.003 -0.019 0.025 0.798 0.975 -0.004 -0.019 0.010 0.544 0.745 0.010 -0.001 0.020 0.086 0.345 -0.003 -0.031 0.025 0.815 0.918SM(d18:2/18:0) -0.014 -0.036 0.008 0.208 0.903 -0.005 -0.019 0.008 0.448 0.673 -0.009 -0.020 0.001 0.087 0.346 -0.050 -0.077 -0.023 0.000 0.008LPE(20:4) [sn2] -0.016 -0.038 0.006 0.164 0.903 -0.010 -0.024 0.004 0.159 0.432 -0.009 -0.020 0.001 0.090 0.346 -0.043 -0.070 -0.015 0.003 0.030PC(16:0_20:3) (a) -0.012 -0.034 0.010 0.276 0.903 -0.011 -0.025 0.003 0.119 0.385 -0.009 -0.020 0.001 0.089 0.346 -0.037 -0.064 -0.011 0.006 0.048LPC(22:0) [sn1] 0.014 -0.008 0.036 0.216 0.903 0.002 -0.012 0.016 0.769 0.881 -0.009 -0.020 0.001 0.090 0.346 0.008 -0.020 0.035 0.590 0.756HexCer(d16:1/18:0) -0.009 -0.032 0.013 0.411 0.922 -0.010 -0.023 0.004 0.162 0.432 -0.009 -0.020 0.001 0.089 0.346 -0.034 -0.062 -0.007 0.014 0.074PE(P-18:0/20:5) 0.010 -0.012 0.033 0.363 0.922 -0.008 -0.023 0.006 0.246 0.501 0.009 -0.001 0.020 0.089 0.346 -0.005 -0.032 0.023 0.748 0.882PC(O-36:0) -0.006 -0.028 0.016 0.590 0.948 -0.008 -0.022 0.006 0.274 0.521 -0.009 -0.020 0.001 0.089 0.346 -0.044 -0.071 -0.017 0.001 0.021TG(O-52:2) [NL-18:1] -0.005 -0.026 0.017 0.674 0.964 -0.004 -0.018 0.010 0.554 0.748 0.009 -0.001 0.020 0.089 0.346 0.018 -0.010 0.046 0.203 0.416TG(54:6) [NL-18:3] -0.001 -0.023 0.021 0.897 0.983 -0.005 -0.018 0.009 0.519 0.727 -0.009 -0.020 0.001 0.087 0.346 -0.002 -0.029 0.026 0.905 0.954LPC(19:1) (a) -0.005 -0.027 0.018 0.687 0.964 -0.010 -0.024 0.004 0.148 0.410 -0.009 -0.020 0.001 0.091 0.347 -0.028 -0.056 -0.001 0.044 0.150DG(16:0_22:6) -0.003 -0.026 0.019 0.762 0.969 -0.011 -0.025 0.003 0.115 0.382 0.009 -0.002 0.020 0.092 0.350 0.009 -0.018 0.037 0.513 0.706DG(18:2_22:6) 0.003 -0.019 0.025 0.782 0.973 -0.008 -0.022 0.006 0.280 0.524 0.009 -0.002 0.020 0.093 0.351 0.008 -0.020 0.036 0.568 0.7430.003 -0.019 0.025 0.760 0.969 -0.010 -0.024 0.004 0.165 0.432 -0.009 -0.020 0.002 0.094 0.354 -0.019 -0.046 0.008 0.172 0.376LPC(20:4) [+OH] 0.006 -0.016 0.029 0.571 0.933 -0.002 -0.015 0.012 0.819 0.907 -0.009 -0.020 0.002 0.095 0.355 -0.021 -0.048 0.006 0.134 0.320CE(16:0) -0.002 -0.024 0.020 0.847 0.981 -0.004 -0.018 0.010 0.548 0.747 -0.009 -0.020 0.002 0.095 0.355 -0.038 -0.065 -0.010 0.007 0.049PE(P-20:1/20:4) 0.004 -0.019 0.026 0.756 0.969 0.001 -0.012 0.015 0.871 0.932 0.009 -0.002 0.020 0.096 0.356 0.016 -0.011 0.043 0.252 0.465HexCer(d18:2/24:0) 0.013 -0.009 0.035 0.243 0.903 -0.003 -0.017 0.011 0.686 0.840 -0.009 -0.020 0.002 0.097 0.358 -0.012 -0.040 0.015 0.376 0.592LPE(20:4) [sn1] -0.019 -0.041 0.003 0.095 0.903 -0.010 -0.024 0.004 0.157 0.432 -0.009 -0.020 0.002 0.109 0.389 -0.038 -0.065 -0.010 0.008 0.053LPC(O-24:0) -0.012 -0.034 0.010 0.284 0.903 -0.021 -0.035 -0.007 0.004 0.259 -0.009 -0.020 0.002 0.107 0.389 -0.036 -0.064 -0.009 0.010 0.062LPE(18:0) [sn2] -0.011 -0.033 0.010 0.304 0.903 -0.010 -0.024 0.003 0.143 0.406 -0.009 -0.020 0.002 0.109 0.389 -0.018 -0.045 0.010 0.202 0.416PC(P-15:0/20:4) (a) -0.007 -0.029 0.015 0.529 0.922 -0.007 -0.021 0.007 0.317 0.557 0.009 -0.002 0.019 0.108 0.389 0.021 -0.006 0.048 0.131 0.317Cer(d20:1/23:0) -0.007 -0.029 0.015 0.527 0.922 -0.006 -0.020 0.008 0.395 0.634 0.009 -0.002 0.020 0.110 0.389 -0.014 -0.041 0.013 0.314 0.537SHexCer(d18:1/24:1(OH)) 0.005 -0.017 0.027 0.667 0.964 -0.005 -0.019 0.009 0.493 0.710 -0.009 -0.020 0.002 0.109 0.389 -0.017 -0.046 0.011 0.239 0.452PC(O-16:0/22:6) -0.002 -0.024 0.020 0.851 0.981 -0.008 -0.022 0.006 0.285 0.530 0.009 -0.002 0.020 0.108 0.389 -0.008 -0.036 0.020 0.573 0.745PC(16:1_22:6) 0.001 -0.021 0.023 0.942 0.995 -0.012 -0.026 0.002 0.085 0.356 -0.009 -0.020 0.002 0.106 0.389 -0.038 -0.065 -0.011 0.007 0.048PC(38:6) (a) 0.001 -0.021 0.024 0.912 0.987 -0.006 -0.020 0.008 0.391 0.632 -0.009 -0.020 0.002 0.111 0.391 -0.025 -0.052 0.003 0.079 0.218LPC(15-MHDA) [sn1] & LPC(17:0) [sn2]LPC(19:0) [sn1] (a) & LPC(19:0) [sn2] (b) ### Page 28 TG(54:0) [NL-18:0] -0.024 -0.046 -0.002 0.030 0.903 -0.016 -0.029 -0.002 0.021 0.273 0.009 -0.002 0.019 0.115 0.403 0.014 -0.014 0.042 0.322 0.540Cer(d18:2/14:0) -0.005 -0.027 0.017 0.679 0.964 -0.007 -0.021 0.007 0.330 0.572 -0.009 -0.020 0.002 0.115 0.404 -0.042 -0.070 -0.015 0.003 0.032Sph(d18:2) 0.012 -0.010 0.034 0.287 0.903 -0.007 -0.021 0.007 0.304 0.546 0.009 -0.002 0.020 0.119 0.404 0.015 -0.010 0.041 0.245 0.458TG(50:0) [NL-18:0] -0.024 -0.046 -0.002 0.032 0.903 -0.012 -0.026 0.001 0.070 0.348 0.008 -0.002 0.019 0.118 0.404 0.012 -0.015 0.040 0.381 0.596PI(34:0) -0.019 -0.041 0.004 0.101 0.903 -0.004 -0.019 0.010 0.555 0.748 0.009 -0.002 0.019 0.118 0.404 -0.011 -0.038 0.016 0.432 0.640TG(51:0) [NL-16:0] -0.023 -0.044 -0.001 0.044 0.903 -0.012 -0.026 0.001 0.069 0.347 0.009 -0.002 0.019 0.116 0.404 0.009 -0.018 0.037 0.518 0.709TG(O-52:2) [NL-16:0] -0.009 -0.030 0.013 0.436 0.922 -0.003 -0.017 0.011 0.655 0.817 0.009 -0.002 0.019 0.118 0.404 0.021 -0.007 0.049 0.138 0.325PC(O-18:1/18:2) -0.002 -0.024 0.020 0.847 0.981 -0.002 -0.016 0.012 0.746 0.876 -0.009 -0.020 0.002 0.118 0.404 -0.025 -0.053 0.002 0.069 0.195SM(d18:1/16:0) -0.010 -0.031 0.012 0.396 0.922 -0.007 -0.021 0.007 0.332 0.572 -0.009 -0.020 0.002 0.119 0.404 -0.050 -0.077 -0.023 0.000 0.008TG(O-50:2) [NL-18:2] -0.013 -0.035 0.009 0.247 0.903 0.002 -0.012 0.016 0.781 0.884 0.009 -0.002 0.019 0.121 0.405 0.025 -0.003 0.053 0.078 0.216PI(16:0/16:0) -0.019 -0.041 0.003 0.096 0.903 0.001 -0.013 0.014 0.944 0.971 0.009 -0.002 0.019 0.121 0.405 0.002 -0.025 0.029 0.901 0.952PC(17:1_18:2) -0.005 -0.027 0.018 0.689 0.964 -0.013 -0.026 0.001 0.076 0.356 -0.009 -0.019 0.002 0.120 0.405 -0.029 -0.056 -0.003 0.032 0.127LPE(16:0) [sn1] -0.017 -0.039 0.005 0.129 0.903 -0.017 -0.030 -0.003 0.015 0.273 -0.008 -0.019 0.002 0.122 0.406 -0.027 -0.054 0.001 0.055 0.173TG(56:8) [NL-22:6] 0.000 -0.022 0.023 0.965 0.995 -0.011 -0.025 0.003 0.132 0.395 0.009 -0.002 0.019 0.124 0.411 0.010 -0.018 0.038 0.468 0.665LPC(22:4) [sn2] -0.012 -0.034 0.009 0.269 0.903 -0.004 -0.018 0.010 0.560 0.748 -0.008 -0.019 0.002 0.129 0.426 -0.019 -0.046 0.009 0.181 0.387LPC(17:1) (a) [sn1] [104_sn1] -0.014 -0.036 0.008 0.229 0.903 -0.019 -0.032 -0.005 0.007 0.259 -0.008 -0.019 0.002 0.131 0.429 -0.030 -0.057 -0.003 0.032 0.127PC(16:0_18:0) -0.010 -0.032 0.012 0.385 0.922 -0.008 -0.022 0.006 0.247 0.501 -0.008 -0.019 0.002 0.131 0.429 -0.040 -0.067 -0.013 0.003 0.037Cer(d17:1/16:0) -0.004 -0.026 0.019 0.736 0.964 -0.001 -0.015 0.013 0.880 0.934 -0.008 -0.019 0.003 0.133 0.432 -0.010 -0.038 0.017 0.469 0.665PI(16:0_20:3) (b) -0.014 -0.036 0.008 0.227 0.903 -0.014 -0.028 0.000 0.050 0.317 -0.008 -0.019 0.003 0.138 0.442 -0.027 -0.054 0.000 0.054 0.172TG(50:3) [NL-14:0] -0.014 -0.036 0.007 0.196 0.903 -0.015 -0.029 -0.002 0.027 0.285 -0.008 -0.019 0.003 0.141 0.442 -0.023 -0.052 0.005 0.105 0.269LPC(18:3) (a) [sn1] [104_sn1] -0.013 -0.035 0.010 0.270 0.903 -0.007 -0.021 0.007 0.301 0.546 -0.008 -0.019 0.003 0.139 0.442 -0.002 -0.030 0.025 0.880 0.948TG(53:2) [NL-17:1] -0.017 -0.038 0.005 0.133 0.903 -0.016 -0.029 -0.002 0.022 0.273 0.008 -0.003 0.019 0.138 0.442 0.000 -0.028 0.027 0.993 0.996S1P(d18:1) -0.010 -0.032 0.012 0.388 0.922 -0.015 -0.029 -0.001 0.040 0.305 -0.008 -0.019 0.003 0.141 0.442 -0.027 -0.054 0.000 0.052 0.170CE(20:4) [+OH] -0.005 -0.027 0.018 0.686 0.964 -0.004 -0.018 0.010 0.564 0.748 -0.008 -0.019 0.003 0.139 0.442 -0.020 -0.048 0.008 0.169 0.373FA(20:4) 0.001 -0.021 0.023 0.912 0.987 -0.004 -0.018 0.010 0.583 0.763 -0.008 -0.019 0.003 0.139 0.442 -0.015 -0.042 0.013 0.299 0.523PA(36:3) 0.000 -0.021 0.022 0.968 0.995 -0.007 -0.021 0.008 0.366 0.602 -0.008 -0.019 0.003 0.140 0.442 -0.008 -0.035 0.020 0.583 0.753PE(O-16:0/22:6) 0.000 -0.022 0.022 0.997 0.999 0.001 -0.013 0.016 0.872 0.932 0.008 -0.003 0.019 0.137 0.442 -0.001 -0.029 0.027 0.931 0.964TG(O-50:2) [NL-18:1] -0.002 -0.024 0.020 0.842 0.981 -0.010 -0.024 0.004 0.172 0.438 0.008 -0.003 0.019 0.143 0.447 -0.001 -0.030 0.027 0.925 0.964TG(54:1) [NL-18:1] -0.021 -0.042 0.001 0.065 0.903 -0.013 -0.027 0.000 0.055 0.317 0.008 -0.003 0.019 0.144 0.448 0.012 -0.016 0.040 0.404 0.620TG(58:8) [NL-22:6] 0.007 -0.015 0.029 0.559 0.933 -0.011 -0.025 0.003 0.133 0.395 0.008 -0.003 0.019 0.146 0.451 0.004 -0.024 0.032 0.793 0.904PC(O-16:0/20:3) -0.007 -0.029 0.015 0.518 0.922 -0.008 -0.022 0.006 0.254 0.506 -0.008 -0.019 0.003 0.150 0.457 -0.039 -0.065 -0.012 0.005 0.044PC(18:1_20:3) -0.009 -0.031 0.013 0.413 0.922 -0.010 -0.024 0.003 0.142 0.406 -0.008 -0.019 0.003 0.150 0.457 -0.034 -0.061 -0.007 0.014 0.074Cer(d17:1/24:1) -0.010 -0.032 0.012 0.364 0.922 -0.017 -0.031 -0.003 0.018 0.273 -0.008 -0.019 0.003 0.149 0.457 -0.029 -0.057 -0.002 0.038 0.138PE(P-18:1/18:1) (a) 0.010 -0.012 0.033 0.363 0.922 0.002 -0.012 0.016 0.793 0.891 0.008 -0.003 0.019 0.149 0.457 -0.008 -0.036 0.020 0.562 0.739DE(22:6) 0.010 -0.012 0.032 0.368 0.922 0.004 -0.010 0.018 0.566 0.748 -0.008 -0.019 0.003 0.152 0.461 -0.024 -0.051 0.004 0.099 0.256TG(O-52:0) [NL-16:0] -0.023 -0.045 -0.002 0.035 0.903 -0.009 -0.022 0.004 0.190 0.454 0.008 -0.003 0.018 0.156 0.463 0.008 -0.019 0.035 0.552 0.730PC(16:1_20:4) -0.009 -0.031 0.013 0.421 0.922 -0.003 -0.017 0.011 0.696 0.845 -0.008 -0.019 0.003 0.157 0.463 -0.032 -0.060 -0.005 0.023 0.099PC(P-16:0/20:4) -0.010 -0.032 0.012 0.389 0.922 0.001 -0.013 0.015 0.845 0.927 0.008 -0.003 0.019 0.157 0.463 -0.002 -0.030 0.025 0.860 0.937dhCer(d18:0/16:0) -0.008 -0.030 0.014 0.479 0.922 -0.003 -0.017 0.011 0.651 0.815 0.008 -0.003 0.018 0.154 0.463 0.001 -0.026 0.029 0.932 0.964PE(P-18:1/22:6) (b) 0.004 -0.018 0.026 0.734 0.964 -0.006 -0.020 0.009 0.435 0.666 -0.008 -0.019 0.003 0.155 0.463 -0.036 -0.062 -0.009 0.008 0.053PC(18:2_18:2) -0.004 -0.026 0.018 0.742 0.964 -0.001 -0.015 0.013 0.855 0.929 -0.008 -0.019 0.003 0.154 0.463 -0.003 -0.031 0.024 0.815 0.918PC(P-17:0/20:4) (b) -0.003 -0.025 0.019 0.812 0.980 -0.002 -0.016 0.012 0.778 0.884 0.008 -0.003 0.018 0.155 0.463 -0.001 -0.028 0.026 0.942 0.966LPC(18:2) [sn1] -0.008 -0.030 0.014 0.476 0.922 -0.008 -0.022 0.005 0.241 0.495 -0.008 -0.019 0.003 0.159 0.466 -0.014 -0.042 0.014 0.330 0.547PIP1(38:4) -0.006 -0.028 0.016 0.601 0.950 -0.007 -0.021 0.006 0.290 0.536 -0.008 -0.018 0.003 0.159 0.466 -0.035 -0.062 -0.008 0.011 0.062TG(50:3) [NL-14:1] -0.012 -0.034 0.010 0.278 0.903 -0.017 -0.031 -0.004 0.012 0.273 -0.008 -0.019 0.003 0.160 0.466 -0.033 -0.061 -0.005 0.023 0.101CE(18:2) [+OH] -0.008 -0.030 0.014 0.468 0.922 -0.012 -0.026 0.002 0.089 0.356 -0.008 -0.019 0.003 0.162 0.472 -0.017 -0.045 0.010 0.225 0.434PC(P-18:1/18:1) -0.003 -0.025 0.019 0.779 0.973 -0.008 -0.022 0.005 0.236 0.493 -0.008 -0.019 0.003 0.164 0.474 -0.035 -0.062 -0.008 0.012 0.066PI(18:0_20:4) -0.019 -0.041 0.002 0.077 0.903 -0.014 -0.027 0.000 0.055 0.317 -0.008 -0.018 0.003 0.165 0.475 -0.040 -0.067 -0.013 0.004 0.038TG(O-52:1) [NL-16:0] -0.015 -0.036 0.007 0.177 0.903 -0.007 -0.020 0.007 0.337 0.574 0.008 -0.003 0.018 0.165 0.475 0.009 -0.018 0.036 0.529 0.718PE(P-18:1/22:6) (a) 0.012 -0.010 0.034 0.286 0.903 -0.003 -0.018 0.011 0.682 0.840 0.008 -0.003 0.018 0.167 0.477 -0.009 -0.037 0.019 0.536 0.720TG(51:1) [NL-17:0] -0.024 -0.045 -0.002 0.033 0.903 -0.015 -0.029 -0.001 0.031 0.291 0.007 -0.003 0.018 0.169 0.482 -0.001 -0.029 0.027 0.954 0.969SM(40:3) (a) -0.010 -0.032 0.012 0.389 0.922 -0.007 -0.021 0.006 0.293 0.536 -0.008 -0.018 0.003 0.172 0.484 -0.045 -0.071 -0.018 0.001 0.018SHexCer(d18:1/16:0(OH)) -0.007 -0.029 0.015 0.533 0.923 0.001 -0.013 0.015 0.889 0.939 -0.008 -0.018 0.003 0.172 0.484 -0.032 -0.060 -0.004 0.025 0.106DG(18:2_18:2) -0.006 -0.028 0.016 0.576 0.933 -0.002 -0.016 0.012 0.779 0.884 -0.008 -0.018 0.003 0.171 0.484 -0.012 -0.039 0.015 0.394 0.609 ### Page 29 -0.013 -0.035 0.010 0.261 0.903 -0.004 -0.018 0.010 0.561 0.748 -0.007 -0.018 0.003 0.174 0.487 -0.001 -0.028 0.026 0.941 0.966TG(52:3) [NL-18:2] -0.010 -0.031 0.011 0.367 0.922 -0.012 -0.026 0.002 0.092 0.356 -0.007 -0.018 0.003 0.174 0.487 -0.027 -0.055 0.001 0.057 0.174TG(52:4) [NL-18:3] -0.019 -0.041 0.002 0.081 0.903 -0.015 -0.029 -0.002 0.028 0.285 -0.007 -0.018 0.003 0.180 0.487 -0.022 -0.050 0.006 0.123 0.300TG(52:1) [NL-18:0] -0.018 -0.040 0.004 0.108 0.903 -0.013 -0.027 0.000 0.057 0.317 0.007 -0.003 0.018 0.179 0.487 0.006 -0.021 0.034 0.657 0.814PS(40:5) 0.017 -0.005 0.039 0.131 0.903 -0.013 -0.027 0.000 0.058 0.319 -0.007 -0.018 0.003 0.179 0.487 -0.004 -0.032 0.024 0.778 0.894PE(O-16:0/20:4) -0.008 -0.030 0.014 0.452 0.922 0.002 -0.012 0.016 0.742 0.874 0.007 -0.003 0.018 0.179 0.487 -0.002 -0.030 0.026 0.886 0.948PI(36:2) -0.007 -0.028 0.015 0.547 0.929 0.000 -0.015 0.014 0.948 0.972 -0.007 -0.018 0.003 0.178 0.487 -0.018 -0.045 0.009 0.191 0.402PE(P-18:1/18:1) (b) -0.006 -0.029 0.016 0.576 0.933 0.004 -0.010 0.018 0.587 0.764 -0.007 -0.018 0.003 0.178 0.487 -0.032 -0.058 -0.005 0.019 0.090TG(54:7) [NL-22:6] -0.005 -0.027 0.018 0.689 0.964 -0.015 -0.029 -0.001 0.037 0.301 0.008 -0.003 0.018 0.176 0.487 0.004 -0.024 0.032 0.767 0.892AC(22:5) 0.003 -0.019 0.025 0.798 0.975 -0.015 -0.029 -0.002 0.029 0.289 -0.007 -0.018 0.003 0.177 0.487 -0.011 -0.038 0.016 0.417 0.631PE(15-MHDA_18:1) -0.015 -0.037 0.008 0.203 0.903 -0.014 -0.028 0.000 0.045 0.306 0.007 -0.004 0.018 0.187 0.499 -0.019 -0.047 0.009 0.188 0.401PE(16:1_18:2) -0.021 -0.043 0.001 0.063 0.903 -0.013 -0.026 0.001 0.073 0.350 -0.007 -0.018 0.004 0.189 0.499 -0.017 -0.044 0.010 0.205 0.416LPC(18:3) [sn1] (b) -0.016 -0.038 0.007 0.173 0.903 -0.008 -0.022 0.006 0.263 0.514 -0.007 -0.018 0.004 0.189 0.499 0.002 -0.026 0.029 0.914 0.959LPC(P-16:0) -0.010 -0.032 0.012 0.369 0.922 -0.007 -0.021 0.007 0.324 0.563 -0.007 -0.018 0.004 0.187 0.499 -0.015 -0.042 0.012 0.284 0.509PE(P-16:0/20:3) (b) -0.009 -0.031 0.013 0.426 0.922 -0.001 -0.015 0.013 0.879 0.934 0.007 -0.004 0.018 0.186 0.499 -0.010 -0.038 0.017 0.456 0.660PC(O-36:5) 0.010 -0.012 0.032 0.381 0.922 -0.009 -0.023 0.005 0.194 0.454 0.007 -0.004 0.018 0.187 0.499 -0.002 -0.029 0.026 0.910 0.956PE(O-38:5) (a) -0.007 -0.029 0.016 0.560 0.933 0.007 -0.007 0.021 0.309 0.550 0.007 -0.004 0.018 0.188 0.499 -0.009 -0.037 0.019 0.529 0.718PE(O-38:5) (b) -0.002 -0.025 0.020 0.826 0.981 -0.004 -0.018 0.010 0.586 0.763 0.007 -0.003 0.018 0.186 0.499 -0.013 -0.040 0.014 0.343 0.563HexCer(d18:1/24:0) 0.012 -0.010 0.034 0.285 0.903 -0.001 -0.015 0.012 0.859 0.929 -0.007 -0.018 0.004 0.191 0.501 -0.014 -0.042 0.013 0.304 0.527Cer(d18:2/23:0) -0.009 -0.031 0.013 0.431 0.922 -0.005 -0.019 0.009 0.512 0.724 -0.007 -0.018 0.004 0.191 0.501 -0.022 -0.050 0.005 0.110 0.276TG(O-50:1) [NL-17:1] -0.007 -0.029 0.014 0.512 0.922 -0.006 -0.020 0.008 0.393 0.633 0.007 -0.004 0.018 0.194 0.505 0.019 -0.008 0.047 0.173 0.378PE(16:1_20:4) -0.022 -0.044 0.000 0.053 0.903 -0.010 -0.024 0.003 0.142 0.406 -0.007 -0.018 0.004 0.194 0.505 -0.014 -0.041 0.013 0.306 0.527Cer(m18:1/23:0) -0.016 -0.038 0.006 0.166 0.903 -0.008 -0.022 0.006 0.251 0.503 0.007 -0.004 0.018 0.196 0.509 0.001 -0.026 0.029 0.925 0.964dhCer(d18:0/24:1) -0.009 -0.031 0.013 0.422 0.922 -0.006 -0.020 0.007 0.363 0.601 0.007 -0.004 0.018 0.197 0.509 -0.011 -0.038 0.017 0.447 0.652PE(P-18:0/18:1) 0.000 -0.022 0.022 0.985 0.996 0.002 -0.012 0.016 0.805 0.898 0.007 -0.004 0.018 0.198 0.510 -0.004 -0.032 0.023 0.761 0.891PC(20:0_20:4) 0.008 -0.014 0.030 0.495 0.922 0.009 -0.005 0.022 0.215 0.476 -0.007 -0.018 0.004 0.200 0.511 -0.018 -0.046 0.009 0.191 0.402SM(d18:2/22:0) 0.004 -0.018 0.026 0.728 0.964 0.004 -0.009 0.018 0.534 0.738 -0.007 -0.018 0.004 0.201 0.511 -0.029 -0.055 -0.002 0.037 0.134Hex2Cer(d16:1/16:0) -0.002 -0.024 0.021 0.883 0.981 -0.002 -0.016 0.012 0.775 0.884 -0.007 -0.018 0.004 0.200 0.511 -0.020 -0.047 0.008 0.162 0.362Cer(d16:1/20:0) -0.015 -0.037 0.007 0.187 0.903 -0.013 -0.026 0.001 0.071 0.349 -0.007 -0.018 0.004 0.202 0.512 -0.026 -0.054 0.001 0.064 0.184PC(O-34:1) -0.009 -0.031 0.013 0.445 0.922 -0.012 -0.026 0.002 0.097 0.361 -0.007 -0.018 0.004 0.202 0.512 -0.035 -0.062 -0.008 0.012 0.067PC(O-16:0/16:0) -0.016 -0.038 0.006 0.149 0.903 -0.011 -0.025 0.003 0.114 0.382 -0.007 -0.018 0.004 0.205 0.516 -0.033 -0.060 -0.006 0.017 0.085PI(18:0_20:3) (a) -0.022 -0.044 0.000 0.054 0.903 -0.016 -0.030 -0.003 0.021 0.273 -0.007 -0.018 0.004 0.209 0.524 -0.035 -0.063 -0.008 0.013 0.068PE(16:0_18:3) (a) -0.019 -0.041 0.003 0.097 0.903 -0.007 -0.021 0.007 0.312 0.555 -0.007 -0.018 0.004 0.209 0.524 -0.011 -0.038 0.016 0.423 0.635SHexCer(d18:1/16:0) -0.009 -0.031 0.013 0.442 0.922 -0.011 -0.025 0.003 0.124 0.385 -0.007 -0.018 0.004 0.212 0.528 -0.025 -0.052 0.003 0.078 0.217PI(18:0_20:2) -0.020 -0.041 0.002 0.073 0.903 -0.017 -0.032 -0.003 0.016 0.273 -0.007 -0.018 0.004 0.212 0.528 -0.027 -0.053 0.000 0.047 0.157TG(50:4) [NL-14:0] -0.014 -0.036 0.008 0.213 0.903 -0.009 -0.023 0.005 0.192 0.454 -0.007 -0.018 0.004 0.213 0.529 -0.005 -0.032 0.023 0.750 0.882FA(18:3) 0.001 -0.021 0.023 0.937 0.995 0.003 -0.011 0.017 0.701 0.846 -0.007 -0.018 0.004 0.215 0.531 -0.009 -0.037 0.019 0.545 0.728Cer(d19:1/20:0) -0.001 -0.023 0.021 0.959 0.995 -0.008 -0.022 0.006 0.278 0.524 -0.007 -0.018 0.004 0.216 0.532 -0.039 -0.068 -0.011 0.006 0.048TG(52:5) [NL-18:3] -0.012 -0.034 0.010 0.280 0.903 -0.006 -0.020 0.008 0.396 0.634 -0.007 -0.017 0.004 0.221 0.539 -0.007 -0.035 0.020 0.605 0.768PE(O-18:0/20:4) -0.008 -0.030 0.014 0.463 0.922 0.005 -0.009 0.019 0.495 0.711 0.007 -0.004 0.017 0.221 0.539 0.008 -0.019 0.035 0.570 0.745AC(22:5)-OH 0.003 -0.019 0.025 0.808 0.980 -0.007 -0.020 0.007 0.350 0.592 0.007 -0.004 0.018 0.220 0.539 0.005 -0.022 0.033 0.703 0.845Hex3Cer(d18:1/24:0) -0.001 -0.023 0.021 0.946 0.995 -0.004 -0.018 0.010 0.565 0.748 -0.007 -0.017 0.004 0.220 0.539 -0.028 -0.055 -0.001 0.045 0.153LPC(16:1) [sn2] -0.014 -0.036 0.008 0.217 0.903 -0.010 -0.023 0.004 0.166 0.432 -0.007 -0.017 0.004 0.222 0.539 -0.026 -0.053 0.001 0.056 0.173Cer(d18:1/22:0) -0.012 -0.034 0.010 0.290 0.903 -0.001 -0.015 0.013 0.885 0.938 -0.007 -0.017 0.004 0.229 0.551 -0.018 -0.045 0.009 0.189 0.401SHexCer(d18:1/24:0(OH)) -0.011 -0.034 0.011 0.323 0.922 0.004 -0.010 0.018 0.563 0.748 -0.007 -0.017 0.004 0.229 0.551 -0.023 -0.051 0.006 0.116 0.289CE(20:4) 0.008 -0.014 0.030 0.482 0.922 0.014 0.000 0.028 0.044 0.306 -0.007 -0.017 0.004 0.231 0.552 -0.018 -0.046 0.010 0.209 0.419CE(18:3) 0.003 -0.019 0.025 0.794 0.974 0.004 -0.009 0.018 0.539 0.742 -0.007 -0.017 0.004 0.230 0.552 -0.016 -0.044 0.011 0.239 0.452LPC(15-MHDA) [sn1] [104_sn1] -0.007 -0.029 0.015 0.546 0.929 -0.014 -0.028 -0.001 0.041 0.306 -0.007 -0.017 0.004 0.232 0.552 -0.031 -0.059 -0.003 0.028 0.112PC(P-16:0/18:0) -0.012 -0.034 0.010 0.286 0.903 -0.006 -0.020 0.008 0.372 0.608 -0.007 -0.017 0.004 0.233 0.555 -0.037 -0.063 -0.010 0.007 0.049PE(O-18:0/22:6) 0.000 -0.023 0.022 0.987 0.996 -0.001 -0.016 0.013 0.847 0.927 0.007 -0.004 0.017 0.235 0.557 0.002 -0.026 0.030 0.896 0.952Cer(d17:1/20:0) -0.014 -0.036 0.008 0.214 0.903 -0.014 -0.028 0.000 0.053 0.317 -0.006 -0.017 0.004 0.240 0.562 -0.035 -0.063 -0.007 0.014 0.074PG(34:1) -0.015 -0.037 0.007 0.188 0.903 -0.020 -0.034 -0.007 0.004 0.259 -0.006 -0.017 0.004 0.240 0.562 -0.017 -0.045 0.011 0.225 0.434-0.008 -0.031 0.014 0.454 0.922 -0.018 -0.031 -0.004 0.010 0.270 -0.006 -0.017 0.004 0.240 0.562 -0.028 -0.055 -0.001 0.043 0.149DE(16:0) 0.009 -0.013 0.031 0.418 0.922 0.016 0.003 0.030 0.021 0.273 -0.006 -0.017 0.004 0.238 0.562 -0.017 -0.043 0.010 0.210 0.420LPC(18:3) [sn1] (a) & LPC(18:3) [sn2] (b)LPC(17:1) [sn1] (a) & LPC(17:1) [sn2] (b) ### Page 30 PE(P-18:1/22:5) (a) 0.004 -0.018 0.026 0.730 0.964 0.000 -0.015 0.014 0.966 0.980 -0.007 -0.017 0.004 0.244 0.565 -0.049 -0.076 -0.022 0.000 0.009SM(43:1) 0.004 -0.018 0.026 0.708 0.964 -0.004 -0.018 0.010 0.588 0.764 0.006 -0.004 0.017 0.244 0.565 -0.018 -0.045 0.009 0.195 0.408PE(P-20:0/18:1) -0.004 -0.026 0.018 0.744 0.964 -0.005 -0.020 0.009 0.445 0.672 0.006 -0.004 0.017 0.244 0.565 -0.002 -0.030 0.025 0.872 0.944CE(22:6) [+OH] -0.001 -0.023 0.022 0.956 0.995 -0.011 -0.024 0.003 0.120 0.385 -0.007 -0.018 0.005 0.244 0.565 -0.015 -0.043 0.013 0.287 0.509TG(52:1) [NL-18:1] -0.020 -0.042 0.002 0.074 0.903 -0.014 -0.027 0.000 0.051 0.317 0.006 -0.004 0.017 0.250 0.565 0.004 -0.024 0.032 0.789 0.904TG(O-54:2) [NL-18:1] -0.007 -0.029 0.015 0.515 0.922 -0.004 -0.018 0.009 0.542 0.743 0.006 -0.004 0.017 0.246 0.565 0.005 -0.022 0.033 0.706 0.845SM(d18:2/17:0) -0.003 -0.025 0.019 0.766 0.969 -0.003 -0.017 0.011 0.668 0.829 -0.006 -0.017 0.004 0.247 0.565 -0.048 -0.074 -0.021 0.001 0.012CE(24:1) -0.003 -0.026 0.019 0.786 0.973 -0.002 -0.015 0.012 0.814 0.903 -0.006 -0.017 0.004 0.249 0.565 -0.027 -0.055 0.000 0.047 0.156PI(20:0_20:4) -0.003 -0.025 0.019 0.791 0.973 0.001 -0.013 0.015 0.899 0.942 -0.006 -0.017 0.004 0.247 0.565 -0.010 -0.039 0.018 0.478 0.672AC(16:1)-OH -0.003 -0.025 0.019 0.813 0.980 -0.010 -0.024 0.004 0.145 0.406 -0.006 -0.017 0.004 0.250 0.565 -0.036 -0.063 -0.008 0.011 0.063LPC(19:0) (a) [sn1] [104_sn1] 0.002 -0.021 0.024 0.889 0.981 -0.009 -0.022 0.005 0.231 0.488 -0.006 -0.017 0.004 0.249 0.565 -0.015 -0.042 0.013 0.294 0.518Hex3Cer(d18:1/24:1) -0.005 -0.028 0.017 0.629 0.954 -0.007 -0.022 0.007 0.307 0.549 -0.006 -0.017 0.004 0.252 0.568 -0.040 -0.068 -0.012 0.005 0.044Sph(d18:1) 0.006 -0.016 0.028 0.609 0.950 -0.006 -0.020 0.009 0.449 0.673 -0.006 -0.017 0.005 0.253 0.568 0.006 -0.022 0.034 0.681 0.827DG(18:1_20:5) -0.004 -0.026 0.018 0.729 0.964 -0.011 -0.025 0.003 0.122 0.385 0.006 -0.005 0.017 0.254 0.569 -0.002 -0.030 0.026 0.894 0.952PC(P-17:0/20:4) (a) -0.002 -0.024 0.020 0.871 0.981 -0.007 -0.020 0.007 0.357 0.598 0.006 -0.004 0.017 0.255 0.569 0.002 -0.025 0.029 0.888 0.948PE(P-16:0/18:2) -0.012 -0.034 0.011 0.306 0.903 0.002 -0.012 0.016 0.804 0.898 0.006 -0.005 0.017 0.258 0.572 -0.003 -0.031 0.024 0.812 0.917TG(52:5) [NL-20:5] -0.007 -0.029 0.015 0.545 0.929 -0.009 -0.023 0.004 0.179 0.450 0.006 -0.005 0.017 0.257 0.572 0.005 -0.023 0.033 0.720 0.854TG(58:10) [NL-22:6] 0.006 -0.016 0.028 0.609 0.950 -0.006 -0.020 0.008 0.367 0.603 0.006 -0.005 0.017 0.262 0.581 0.020 -0.007 0.048 0.151 0.345LPC(22:5) [sn1] (n6) -0.012 -0.034 0.009 0.270 0.903 -0.003 -0.017 0.011 0.672 0.831 -0.006 -0.017 0.005 0.263 0.581 -0.011 -0.038 0.016 0.428 0.638-0.004 -0.026 0.018 0.738 0.964 0.000 -0.014 0.013 0.948 0.972 0.006 -0.005 0.017 0.264 0.582 -0.016 -0.042 0.011 0.249 0.464HexCer(d18:1/16:0) 0.011 -0.012 0.033 0.349 0.922 -0.004 -0.018 0.010 0.594 0.767 -0.006 -0.017 0.005 0.267 0.586 -0.037 -0.065 -0.010 0.008 0.051LPC(18:2) [sn2] -0.002 -0.025 0.020 0.839 0.981 -0.003 -0.017 0.011 0.650 0.814 -0.006 -0.017 0.005 0.268 0.587 -0.006 -0.034 0.022 0.668 0.818S1P(d18:2) -0.009 -0.031 0.013 0.429 0.922 0.002 -0.011 0.016 0.733 0.870 -0.006 -0.017 0.005 0.270 0.588 -0.017 -0.044 0.010 0.214 0.422PE(17:0_18:2) -0.011 -0.033 0.011 0.320 0.922 -0.016 -0.029 -0.002 0.026 0.285 -0.006 -0.017 0.005 0.271 0.588 -0.013 -0.040 0.015 0.367 0.586PC(18:0_18:2) -0.007 -0.029 0.015 0.530 0.922 -0.009 -0.023 0.005 0.206 0.467 -0.006 -0.017 0.005 0.271 0.588 -0.036 -0.064 -0.009 0.010 0.061PC(16:0_18:3) (b) -0.021 -0.043 0.001 0.065 0.903 -0.009 -0.023 0.005 0.203 0.465 -0.006 -0.017 0.005 0.273 0.588 -0.035 -0.062 -0.007 0.013 0.070TG(48:0) [NL-16:0] -0.023 -0.045 -0.001 0.041 0.903 -0.005 -0.019 0.009 0.471 0.689 0.006 -0.005 0.017 0.273 0.588 0.013 -0.014 0.041 0.337 0.554LPC(24:0) [sn1] 0.011 -0.011 0.033 0.321 0.922 0.002 -0.012 0.016 0.749 0.877 -0.006 -0.017 0.005 0.273 0.588 0.005 -0.023 0.033 0.710 0.847-0.007 -0.029 0.015 0.520 0.922 -0.010 -0.024 0.003 0.145 0.406 -0.006 -0.017 0.005 0.275 0.589 -0.055 -0.082 -0.027 0.000 0.006LPC(P-17:0) (a) -0.003 -0.025 0.019 0.766 0.969 -0.010 -0.024 0.003 0.142 0.406 -0.006 -0.017 0.005 0.275 0.589 -0.020 -0.047 0.008 0.159 0.358AC(13:0) 0.011 -0.011 0.033 0.326 0.922 -0.012 -0.025 0.002 0.097 0.361 0.006 -0.005 0.017 0.277 0.590 0.010 -0.018 0.038 0.484 0.676LPC(15-MHDA) [sn2] -0.006 -0.028 0.017 0.614 0.950 -0.014 -0.028 0.000 0.051 0.317 -0.006 -0.017 0.005 0.279 0.590 -0.030 -0.058 -0.002 0.034 0.132CE(20:3) 0.003 -0.019 0.025 0.813 0.980 -0.002 -0.015 0.012 0.817 0.905 -0.006 -0.017 0.005 0.279 0.590 -0.039 -0.067 -0.011 0.006 0.048SHexCer(d18:1/24:1) -0.001 -0.023 0.021 0.910 0.987 -0.006 -0.020 0.007 0.364 0.602 -0.006 -0.017 0.005 0.279 0.590 -0.024 -0.052 0.003 0.081 0.220TG(48:0) [NL-18:0] -0.021 -0.043 0.001 0.062 0.903 -0.009 -0.022 0.004 0.190 0.454 0.006 -0.005 0.017 0.284 0.594 0.010 -0.018 0.037 0.502 0.699Cer(d16:1/24:1) -0.011 -0.033 0.011 0.334 0.922 -0.019 -0.033 -0.005 0.008 0.265 -0.006 -0.017 0.005 0.284 0.594 -0.024 -0.052 0.004 0.088 0.236TG(56:7) [NL-20:5] 0.006 -0.016 0.028 0.615 0.950 -0.010 -0.024 0.004 0.158 0.432 0.006 -0.005 0.017 0.282 0.594 -0.003 -0.031 0.025 0.827 0.923PC(35:5) 0.004 -0.018 0.026 0.723 0.964 -0.008 -0.022 0.005 0.236 0.493 0.006 -0.005 0.017 0.284 0.594 -0.012 -0.040 0.016 0.400 0.617TG(50:3) [NL-18:2] -0.018 -0.039 0.004 0.112 0.903 -0.014 -0.028 -0.001 0.040 0.306 -0.006 -0.016 0.005 0.290 0.597 -0.029 -0.057 -0.001 0.045 0.153PE(16:0_18:3) (b) -0.026 -0.048 -0.004 0.022 0.903 -0.008 -0.022 0.005 0.224 0.485 -0.006 -0.017 0.005 0.289 0.597 -0.010 -0.037 0.017 0.460 0.663LPC(19:1) (c) -0.006 -0.029 0.016 0.589 0.948 -0.011 -0.025 0.002 0.096 0.361 -0.006 -0.017 0.005 0.290 0.597 -0.029 -0.056 -0.002 0.039 0.139FA(17:1) -0.004 -0.027 0.019 0.738 0.964 0.004 -0.010 0.018 0.560 0.748 0.006 -0.005 0.017 0.288 0.597 0.013 -0.014 0.040 0.335 0.553LPI(18:2) [sn2] -0.004 -0.027 0.018 0.691 0.964 0.006 -0.008 0.020 0.373 0.608 -0.006 -0.017 0.005 0.289 0.597 -0.010 -0.037 0.017 0.461 0.664Hex2Cer(d18:2/24:1) 0.002 -0.021 0.024 0.886 0.981 0.000 -0.014 0.014 0.998 0.998 -0.006 -0.017 0.005 0.288 0.597 -0.024 -0.052 0.004 0.091 0.241PE(P-16:0/22:5) (n3) -0.015 -0.037 0.007 0.189 0.903 0.006 -0.009 0.020 0.445 0.672 0.006 -0.005 0.017 0.293 0.598 -0.024 -0.052 0.003 0.086 0.230TG(58:9) [NL-22:6] 0.008 -0.014 0.030 0.472 0.922 -0.010 -0.024 0.004 0.161 0.432 0.006 -0.005 0.017 0.292 0.598 0.013 -0.015 0.041 0.359 0.577PE(18:0_22:6) -0.005 -0.027 0.017 0.652 0.960 -0.011 -0.025 0.002 0.109 0.379 0.006 -0.005 0.017 0.294 0.598 -0.003 -0.031 0.024 0.804 0.910PE(O-34:1) 0.001 -0.021 0.024 0.908 0.987 0.005 -0.009 0.019 0.506 0.722 0.006 -0.005 0.017 0.294 0.598 -0.003 -0.030 0.025 0.850 0.933Cer(d17:1/18:0) -0.013 -0.036 0.009 0.238 0.903 -0.008 -0.022 0.006 0.248 0.501 -0.006 -0.016 0.005 0.295 0.598 -0.037 -0.065 -0.010 0.008 0.053PE(16:0_16:0) -0.023 -0.045 -0.002 0.036 0.903 -0.008 -0.021 0.006 0.249 0.501 -0.006 -0.016 0.005 0.298 0.598 -0.008 -0.035 0.019 0.552 0.730Cer(d20:1/22:0) -0.009 -0.030 0.013 0.440 0.922 0.003 -0.011 0.017 0.673 0.831 0.006 -0.005 0.016 0.296 0.598 -0.007 -0.034 0.020 0.601 0.765Hex2Cer(d18:1/24:1) -0.005 -0.027 0.017 0.654 0.960 -0.008 -0.022 0.006 0.239 0.495 -0.006 -0.017 0.005 0.298 0.598 -0.024 -0.051 0.004 0.096 0.250PC(39:5) (b) -0.002 -0.024 0.021 0.863 0.981 -0.015 -0.028 -0.001 0.033 0.298 -0.006 -0.016 0.005 0.297 0.598 -0.051 -0.078 -0.024 0.000 0.008HexCer(d18:2/20:0) 0.000 -0.022 0.022 0.993 0.997 -0.006 -0.020 0.008 0.411 0.646 -0.006 -0.017 0.005 0.299 0.598 -0.018 -0.046 0.010 0.204 0.416SM(d18:1/23:0) & SM(d17:1/24:0)PC(18:0_22:5) (n3) & PC(20:1_20:4) ### Page 31 Cer(m18:1/24:0) -0.017 -0.039 0.005 0.126 0.903 -0.006 -0.020 0.008 0.405 0.643 0.006 -0.005 0.016 0.304 0.605 0.003 -0.024 0.031 0.819 0.920TG(54:3) [NL-18:1] 0.006 -0.016 0.027 0.616 0.950 -0.014 -0.028 0.000 0.048 0.317 -0.006 -0.016 0.005 0.304 0.605 -0.017 -0.045 0.010 0.216 0.425TG(56:9) [NL-22:6] 0.003 -0.019 0.025 0.783 0.973 -0.009 -0.023 0.005 0.186 0.453 0.006 -0.005 0.017 0.306 0.605 0.014 -0.014 0.041 0.337 0.554PE(18:1_22:6) (a) -0.003 -0.024 0.019 0.820 0.980 -0.014 -0.028 0.000 0.044 0.306 -0.006 -0.016 0.005 0.305 0.605 -0.010 -0.038 0.018 0.471 0.665CE(18:1) 0.000 -0.022 0.022 0.976 0.995 -0.015 -0.029 -0.002 0.030 0.289 -0.006 -0.017 0.005 0.307 0.605 -0.032 -0.059 -0.004 0.025 0.105LPC(26:0) [sn1] 0.000 -0.023 0.022 0.973 0.995 -0.009 -0.023 0.005 0.214 0.476 -0.006 -0.017 0.005 0.308 0.605 -0.029 -0.056 -0.001 0.042 0.147FA(18:2) 0.000 -0.022 0.022 0.998 0.999 0.005 -0.009 0.018 0.511 0.724 -0.006 -0.017 0.005 0.307 0.605 -0.007 -0.034 0.021 0.636 0.798TG(50:3) [NL-16:1] -0.021 -0.043 0.001 0.059 0.903 -0.017 -0.031 -0.004 0.014 0.273 -0.006 -0.016 0.005 0.309 0.606 -0.030 -0.058 -0.003 0.032 0.126DG(18:0_18:1) -0.017 -0.038 0.005 0.136 0.903 -0.015 -0.029 -0.002 0.026 0.285 0.006 -0.005 0.016 0.311 0.609 -0.003 -0.031 0.025 0.853 0.933PE(P-18:0/20:3) (a) -0.009 -0.031 0.014 0.449 0.922 -0.004 -0.018 0.010 0.566 0.748 0.006 -0.005 0.016 0.313 0.610 -0.015 -0.042 0.012 0.275 0.499PS(38:3) -0.002 -0.024 0.020 0.880 0.981 -0.001 -0.015 0.012 0.857 0.929 0.006 -0.005 0.016 0.314 0.611 0.018 -0.009 0.046 0.181 0.387-0.017 -0.039 0.005 0.129 0.903 -0.008 -0.021 0.006 0.276 0.524 -0.006 -0.016 0.005 0.316 0.613 -0.047 -0.075 -0.020 0.001 0.014PE(P-20:0/18:2) -0.003 -0.025 0.019 0.813 0.980 0.001 -0.013 0.015 0.936 0.968 -0.006 -0.016 0.005 0.317 0.613 -0.014 -0.042 0.013 0.297 0.521PI(16:0_16:1) -0.017 -0.039 0.005 0.135 0.903 -0.001 -0.015 0.013 0.914 0.951 0.005 -0.005 0.016 0.321 0.616 -0.004 -0.031 0.023 0.774 0.893Cer(m18:1/22:0) -0.014 -0.036 0.008 0.219 0.903 -0.008 -0.022 0.006 0.291 0.536 0.005 -0.005 0.016 0.320 0.616 0.004 -0.024 0.031 0.796 0.905PE(P-20:1/22:6) 0.004 -0.018 0.027 0.696 0.964 -0.010 -0.023 0.004 0.180 0.450 0.005 -0.005 0.016 0.321 0.616 0.007 -0.020 0.035 0.606 0.7690.000 -0.022 0.022 0.989 0.996 -0.003 -0.017 0.011 0.675 0.833 -0.005 -0.016 0.005 0.322 0.616 -0.026 -0.053 0.001 0.063 0.184TG(48:3) [NL-16:1] -0.021 -0.043 0.001 0.066 0.903 -0.014 -0.028 -0.001 0.041 0.306 -0.005 -0.016 0.005 0.324 0.620 -0.017 -0.045 0.010 0.214 0.422AC(24:0) 0.008 -0.014 0.030 0.503 0.922 0.009 -0.005 0.023 0.191 0.454 0.005 -0.005 0.016 0.326 0.620 0.014 -0.013 0.042 0.301 0.524LPC(17:1) [sn2] (a) -0.015 -0.037 0.007 0.193 0.903 -0.018 -0.032 -0.005 0.008 0.263 -0.005 -0.016 0.005 0.328 0.621 -0.027 -0.054 0.001 0.055 0.173TG(49:1) [NL-17:1] -0.019 -0.041 0.003 0.087 0.903 -0.011 -0.024 0.003 0.117 0.385 0.005 -0.005 0.016 0.327 0.621 0.000 -0.027 0.027 0.997 0.997AC(26:0) -0.002 -0.024 0.020 0.890 0.981 0.005 -0.009 0.019 0.516 0.727 0.005 -0.005 0.016 0.329 0.621 0.003 -0.025 0.030 0.836 0.928PC(O-32:1) -0.010 -0.032 0.012 0.391 0.922 -0.006 -0.020 0.008 0.373 0.608 0.005 -0.005 0.016 0.330 0.623 -0.022 -0.050 0.005 0.116 0.289COH -0.005 -0.027 0.017 0.644 0.960 -0.003 -0.017 0.011 0.666 0.829 -0.005 -0.016 0.006 0.332 0.625 -0.040 -0.067 -0.013 0.004 0.038dhCer(d18:0/18:0) -0.026 -0.048 -0.004 0.022 0.903 0.002 -0.011 0.016 0.735 0.870 0.005 -0.005 0.016 0.338 0.634 -0.036 -0.063 -0.009 0.009 0.054Cer(d18:2/24:0) 0.001 -0.021 0.023 0.944 0.995 0.001 -0.013 0.016 0.864 0.930 -0.005 -0.016 0.006 0.339 0.636 -0.008 -0.036 0.020 0.565 0.742DG(18:1_18:3) -0.011 -0.033 0.011 0.343 0.922 -0.009 -0.023 0.005 0.194 0.454 -0.005 -0.016 0.006 0.343 0.641 -0.013 -0.040 0.015 0.372 0.590PC(P-18:0/18:2) -0.006 -0.028 0.016 0.572 0.933 -0.004 -0.018 0.010 0.552 0.748 -0.005 -0.016 0.006 0.344 0.642 -0.021 -0.047 0.006 0.133 0.318TG(54:6) [NL-20:5] 0.000 -0.023 0.022 0.976 0.995 -0.013 -0.027 0.001 0.066 0.338 0.005 -0.006 0.016 0.346 0.643 0.002 -0.026 0.030 0.901 0.952DG(16:0_16:0) -0.014 -0.036 0.008 0.211 0.903 -0.012 -0.026 0.001 0.082 0.356 0.005 -0.006 0.016 0.350 0.648 0.014 -0.014 0.041 0.324 0.541Cer(d18:1/14:0) -0.001 -0.023 0.021 0.933 0.995 -0.005 -0.020 0.009 0.464 0.686 -0.005 -0.016 0.006 0.350 0.648 -0.029 -0.057 -0.001 0.046 0.155methyl-CE(18:2) 0.013 -0.009 0.035 0.249 0.903 0.003 -0.011 0.017 0.694 0.845 -0.005 -0.016 0.006 0.353 0.649 -0.011 -0.039 0.016 0.421 0.634TG(50:4) [NL-18:3] -0.022 -0.044 0.000 0.047 0.903 -0.012 -0.026 0.001 0.076 0.356 -0.005 -0.016 0.006 0.352 0.649 -0.011 -0.039 0.017 0.429 0.638TG(54:3) [NL-18:2] -0.006 -0.027 0.016 0.602 0.950 -0.011 -0.025 0.003 0.117 0.385 -0.005 -0.016 0.006 0.354 0.649 0.001 -0.027 0.029 0.945 0.966FA(16:1) 0.003 -0.019 0.025 0.777 0.973 -0.002 -0.016 0.012 0.764 0.881 -0.005 -0.016 0.006 0.355 0.650 -0.014 -0.042 0.014 0.316 0.537PC(38:2) -0.009 -0.031 0.013 0.423 0.922 -0.005 -0.019 0.009 0.478 0.696 -0.005 -0.016 0.006 0.358 0.654 -0.029 -0.056 -0.002 0.033 0.127Cer(m18:0/24:0) -0.014 -0.036 0.008 0.204 0.903 -0.003 -0.017 0.011 0.719 0.856 0.005 -0.006 0.016 0.360 0.656 0.004 -0.024 0.031 0.791 0.904PC(16:0_20:5) 0.007 -0.015 0.029 0.521 0.922 -0.012 -0.025 0.002 0.105 0.373 0.005 -0.006 0.016 0.361 0.656 -0.011 -0.039 0.017 0.440 0.644PC(17:0_18:2) -0.008 -0.030 0.013 0.455 0.922 -0.011 -0.025 0.003 0.122 0.385 -0.005 -0.016 0.006 0.364 0.660 -0.034 -0.061 -0.007 0.014 0.074AC(17:0) (b) -0.007 -0.029 0.016 0.555 0.933 -0.015 -0.028 -0.001 0.036 0.301 -0.005 -0.016 0.006 0.365 0.660 -0.034 -0.061 -0.008 0.012 0.068PE(P-18:1/20:4) (b) -0.006 -0.028 0.016 0.583 0.940 0.002 -0.012 0.016 0.755 0.879 -0.005 -0.016 0.006 0.366 0.661 -0.031 -0.058 -0.005 0.022 0.097TG(48:1) [NL-16:1] -0.021 -0.043 0.001 0.058 0.903 -0.009 -0.023 0.004 0.186 0.453 0.005 -0.006 0.016 0.368 0.661 0.004 -0.023 0.032 0.768 0.892PE(P-18:1/20:3) (a) -0.009 -0.031 0.013 0.432 0.922 -0.003 -0.017 0.011 0.634 0.803 0.005 -0.006 0.016 0.368 0.661 -0.019 -0.045 0.008 0.175 0.378SM(41:1) (a) 0.001 -0.021 0.023 0.911 0.987 -0.004 -0.018 0.010 0.558 0.748 0.005 -0.006 0.016 0.369 0.661 -0.017 -0.044 0.010 0.211 0.420PC(38:5) (b) 0.002 -0.021 0.024 0.892 0.981 -0.012 -0.026 0.002 0.091 0.356 -0.005 -0.016 0.006 0.370 0.661 -0.047 -0.074 -0.020 0.001 0.014AC(15:0) (a) 0.008 -0.014 0.030 0.473 0.922 -0.015 -0.029 -0.001 0.031 0.291 0.005 -0.006 0.016 0.371 0.662 -0.004 -0.032 0.023 0.749 0.882LPC(22:1) [sn1] 0.011 -0.011 0.033 0.331 0.922 -0.011 -0.024 0.003 0.136 0.399 -0.005 -0.016 0.006 0.374 0.665 -0.009 -0.036 0.019 0.543 0.726Cer(m18:1/18:0) -0.022 -0.044 -0.001 0.045 0.903 -0.009 -0.023 0.004 0.180 0.450 0.005 -0.006 0.016 0.375 0.666 -0.016 -0.043 0.011 0.251 0.465PC(31:0) (a) -0.017 -0.040 0.005 0.129 0.903 -0.009 -0.022 0.005 0.212 0.475 0.005 -0.006 0.016 0.379 0.671 -0.020 -0.048 0.007 0.145 0.335PE(P-18:0/22:5) (n3) -0.009 -0.031 0.013 0.427 0.922 0.004 -0.010 0.019 0.540 0.743 0.005 -0.006 0.016 0.380 0.671 -0.030 -0.057 -0.002 0.035 0.132SM(44:1) 0.012 -0.011 0.034 0.303 0.903 -0.005 -0.019 0.009 0.486 0.704 0.005 -0.006 0.016 0.391 0.680 -0.024 -0.051 0.004 0.093 0.244Cer(m18:0/23:0) -0.015 -0.037 0.008 0.198 0.903 -0.006 -0.020 0.008 0.399 0.638 0.005 -0.006 0.015 0.393 0.680 -0.011 -0.039 0.016 0.427 0.638DG(18:1_18:2) -0.008 -0.030 0.014 0.478 0.922 -0.010 -0.024 0.003 0.147 0.408 -0.005 -0.015 0.006 0.388 0.680 -0.017 -0.045 0.010 0.222 0.430PE(O-18:1/22:6) 0.009 -0.013 0.031 0.415 0.922 -0.001 -0.015 0.013 0.864 0.930 0.005 -0.006 0.015 0.393 0.680 -0.004 -0.032 0.023 0.762 0.891SM(d18:1/18:0) & SM(d16:1/20:0)SM(d18:1/20:0) & SM(d16:1/22:0) ### Page 32 CE(15:0) 0.007 -0.015 0.029 0.534 0.923 -0.006 -0.019 0.008 0.413 0.646 -0.005 -0.015 0.006 0.388 0.680 -0.037 -0.065 -0.009 0.009 0.055PE(P-18:0/20:3) (b) -0.006 -0.028 0.016 0.577 0.933 0.000 -0.014 0.015 0.981 0.989 0.005 -0.006 0.016 0.392 0.680 -0.018 -0.045 0.010 0.204 0.416PC(P-16:0/18:1) -0.004 -0.026 0.018 0.708 0.964 -0.008 -0.022 0.006 0.248 0.501 -0.005 -0.016 0.006 0.391 0.680 -0.032 -0.059 -0.005 0.022 0.098TG(56:7) [NL-20:4] -0.004 -0.026 0.018 0.723 0.964 0.005 -0.009 0.019 0.520 0.727 -0.005 -0.015 0.006 0.392 0.680 -0.003 -0.031 0.025 0.860 0.937CE(22:0) -0.003 -0.025 0.020 0.818 0.980 0.010 -0.004 0.023 0.162 0.432 -0.005 -0.016 0.006 0.392 0.680 -0.009 -0.035 0.018 0.507 0.702Cer(d18:1/23:0) -0.012 -0.034 0.010 0.275 0.903 -0.007 -0.021 0.007 0.353 0.592 -0.005 -0.015 0.006 0.395 0.680 -0.023 -0.050 0.004 0.094 0.246DE(20:4) 0.016 -0.006 0.038 0.150 0.903 0.019 0.005 0.032 0.007 0.263 -0.005 -0.015 0.006 0.395 0.680 0.001 -0.027 0.029 0.945 0.966-0.014 -0.036 0.008 0.216 0.903 0.004 -0.010 0.018 0.599 0.771 -0.005 -0.015 0.006 0.398 0.684 -0.021 -0.047 0.006 0.130 0.315Cer(d19:1/18:0) -0.006 -0.028 0.016 0.568 0.933 -0.009 -0.023 0.005 0.211 0.475 -0.005 -0.015 0.006 0.400 0.685 -0.043 -0.070 -0.016 0.002 0.024DE(20:5) 0.013 -0.010 0.035 0.268 0.903 -0.004 -0.018 0.010 0.555 0.748 0.005 -0.006 0.015 0.402 0.687 -0.008 -0.035 0.020 0.590 0.756PE(38:5) (b) -0.010 -0.032 0.013 0.399 0.922 -0.016 -0.030 -0.003 0.019 0.273 -0.005 -0.015 0.006 0.402 0.687 -0.024 -0.051 0.004 0.088 0.236TG(54:5) [NL-20:4] -0.015 -0.037 0.007 0.178 0.903 -0.007 -0.021 0.006 0.285 0.530 0.004 -0.006 0.015 0.417 0.708 -0.001 -0.029 0.027 0.932 0.964DG(18:1_20:3) -0.011 -0.033 0.011 0.324 0.922 -0.011 -0.025 0.002 0.106 0.373 0.004 -0.006 0.015 0.417 0.708 -0.014 -0.042 0.015 0.346 0.564PG(36:1) -0.020 -0.042 0.002 0.069 0.903 -0.014 -0.028 -0.001 0.038 0.301 0.004 -0.006 0.015 0.418 0.709 0.010 -0.017 0.038 0.466 0.664DG(14:0_18:2) -0.017 -0.040 0.005 0.121 0.903 -0.009 -0.023 0.004 0.176 0.446 -0.004 -0.015 0.006 0.420 0.709 -0.014 -0.042 0.014 0.315 0.537FA(20:2) -0.009 -0.031 0.014 0.449 0.922 0.000 -0.014 0.014 0.982 0.989 -0.005 -0.016 0.007 0.421 0.709 -0.010 -0.038 0.017 0.462 0.664PC(P-16:0/18:3) -0.009 -0.031 0.013 0.423 0.922 -0.005 -0.019 0.009 0.448 0.673 -0.004 -0.015 0.006 0.423 0.709 -0.008 -0.035 0.020 0.583 0.753CE(20:1) 0.005 -0.017 0.027 0.649 0.960 -0.001 -0.015 0.013 0.860 0.929 -0.004 -0.015 0.006 0.422 0.709 -0.026 -0.054 0.002 0.066 0.189PC(34:5) 0.001 -0.022 0.023 0.951 0.995 -0.006 -0.020 0.008 0.406 0.643 0.004 -0.006 0.015 0.422 0.709 -0.004 -0.032 0.024 0.770 0.892AC(24:1)-OH 0.015 -0.007 0.037 0.172 0.903 -0.012 -0.026 0.001 0.071 0.350 -0.004 -0.015 0.006 0.424 0.710 0.007 -0.020 0.034 0.613 0.775TG(O-54:3) [NL-17:1] -0.007 -0.029 0.014 0.501 0.922 -0.005 -0.019 0.009 0.471 0.689 0.004 -0.006 0.015 0.426 0.711 0.003 -0.025 0.031 0.836 0.928CE(24:0) -0.001 -0.023 0.022 0.944 0.995 0.011 -0.003 0.024 0.127 0.385 -0.004 -0.015 0.006 0.427 0.711 -0.010 -0.037 0.017 0.463 0.664PC(16:0_20:3) (b) -0.016 -0.038 0.007 0.168 0.903 -0.011 -0.025 0.002 0.101 0.368 -0.004 -0.015 0.006 0.429 0.712 -0.044 -0.071 -0.017 0.002 0.022Ubiquinone 0.007 -0.015 0.029 0.511 0.922 -0.004 -0.018 0.010 0.577 0.759 -0.004 -0.015 0.006 0.431 0.713 -0.010 -0.038 0.017 0.464 0.664LPI(18:0) [sn1] -0.010 -0.032 0.012 0.360 0.922 -0.002 -0.017 0.013 0.812 0.902 0.004 -0.007 0.015 0.431 0.713 -0.001 -0.029 0.027 0.941 0.966PC(16:0_16:0) -0.014 -0.036 0.008 0.222 0.903 -0.009 -0.023 0.005 0.203 0.464 -0.004 -0.015 0.007 0.435 0.715 -0.029 -0.056 -0.002 0.035 0.133LPE(P-16:0) -0.009 -0.031 0.013 0.426 0.922 -0.006 -0.020 0.009 0.438 0.667 -0.004 -0.015 0.006 0.434 0.715 -0.016 -0.044 0.012 0.275 0.499PE(18:0_18:1) -0.007 -0.029 0.015 0.548 0.929 -0.012 -0.025 0.002 0.095 0.360 0.004 -0.006 0.015 0.434 0.715 0.015 -0.012 0.043 0.280 0.505TG(50:1) [NL-18:1] -0.022 -0.043 0.000 0.052 0.903 -0.011 -0.025 0.003 0.122 0.385 0.004 -0.006 0.015 0.438 0.719 -0.002 -0.030 0.026 0.884 0.948PC(17:0_18:1) -0.015 -0.036 0.007 0.193 0.903 -0.018 -0.032 -0.004 0.010 0.270 -0.004 -0.015 0.007 0.441 0.720 -0.048 -0.075 -0.021 0.001 0.012PE(16:0_18:2) -0.017 -0.038 0.005 0.133 0.903 -0.012 -0.025 0.002 0.104 0.372 -0.004 -0.015 0.007 0.441 0.720 -0.011 -0.039 0.016 0.425 0.636PE(P-18:1/22:5) (b) -0.004 -0.026 0.018 0.722 0.964 0.004 -0.010 0.018 0.549 0.747 -0.004 -0.015 0.007 0.444 0.723 -0.005 -0.032 0.021 0.698 0.842SM(d18:0/16:0) 0.007 -0.015 0.029 0.547 0.929 -0.002 -0.016 0.012 0.810 0.902 -0.004 -0.015 0.007 0.445 0.723 -0.028 -0.055 -0.001 0.042 0.147SM(d18:1/24:0) 0.003 -0.019 0.025 0.805 0.980 0.006 -0.008 0.020 0.418 0.649 0.004 -0.007 0.015 0.446 0.723 -0.008 -0.035 0.019 0.575 0.746Cer(m18:0/22:0) -0.014 -0.036 0.008 0.225 0.903 -0.003 -0.017 0.011 0.640 0.807 0.004 -0.007 0.015 0.450 0.727 -0.007 -0.034 0.021 0.629 0.793PC(O-32:2) -0.013 -0.035 0.009 0.253 0.903 -0.006 -0.020 0.008 0.423 0.655 0.004 -0.007 0.015 0.450 0.727 -0.003 -0.031 0.024 0.802 0.910PC(O-16:0/20:4) -0.007 -0.029 0.014 0.512 0.922 0.003 -0.011 0.017 0.633 0.803 0.004 -0.007 0.015 0.452 0.727 -0.016 -0.043 0.012 0.262 0.482Cer(d18:2/26:0) 0.004 -0.019 0.026 0.745 0.964 0.002 -0.012 0.016 0.804 0.898 -0.004 -0.015 0.007 0.452 0.727 -0.022 -0.050 0.005 0.112 0.278Cer(d16:1/18:0) -0.012 -0.034 0.009 0.267 0.903 -0.014 -0.027 0.000 0.052 0.317 -0.004 -0.015 0.007 0.455 0.727 -0.033 -0.061 -0.006 0.018 0.087AC(18:0)-OH 0.000 -0.022 0.022 0.989 0.996 -0.008 -0.021 0.006 0.278 0.524 -0.004 -0.015 0.007 0.454 0.727 -0.032 -0.060 -0.005 0.021 0.093TG(50:1) [NL-16:0] -0.019 -0.041 0.002 0.082 0.903 -0.009 -0.023 0.004 0.181 0.450 0.004 -0.007 0.015 0.458 0.731 0.001 -0.027 0.029 0.964 0.973AC(26:1) 0.001 -0.021 0.023 0.949 0.995 -0.001 -0.015 0.013 0.857 0.929 -0.004 -0.015 0.007 0.460 0.733 -0.016 -0.043 0.011 0.237 0.450PC(18:0_20:3) -0.010 -0.032 0.011 0.347 0.922 -0.006 -0.019 0.008 0.418 0.649 0.004 -0.007 0.015 0.462 0.734 -0.020 -0.047 0.007 0.145 0.335Cer(d17:1/22:0) -0.007 -0.029 0.015 0.524 0.922 -0.002 -0.016 0.012 0.753 0.879 -0.004 -0.015 0.007 0.468 0.741 -0.016 -0.044 0.011 0.245 0.458LPC(20:4) [sn1] -0.005 -0.027 0.017 0.645 0.960 -0.002 -0.016 0.012 0.730 0.868 -0.004 -0.015 0.007 0.471 0.741 -0.014 -0.042 0.014 0.323 0.541SM(d18:2/16:0) -0.002 -0.024 0.020 0.871 0.981 0.005 -0.009 0.019 0.462 0.686 -0.004 -0.015 0.007 0.470 0.741 -0.027 -0.053 0.000 0.053 0.171PC(18:0_22:6) 0.001 -0.021 0.024 0.895 0.983 -0.008 -0.022 0.006 0.251 0.503 0.004 -0.007 0.015 0.469 0.741 -0.025 -0.053 0.003 0.083 0.224PE(17:0_22:6) 0.001 -0.021 0.023 0.920 0.990 -0.014 -0.028 -0.001 0.038 0.302 0.004 -0.007 0.015 0.467 0.741 -0.004 -0.031 0.024 0.793 0.904PC(P-16:0/16:1) -0.009 -0.031 0.014 0.449 0.922 -0.013 -0.027 0.001 0.066 0.338 -0.004 -0.015 0.007 0.475 0.746 -0.029 -0.056 -0.002 0.034 0.132CE(22:1) 0.011 -0.011 0.033 0.342 0.922 0.001 -0.013 0.014 0.942 0.971 0.004 -0.007 0.015 0.476 0.746 -0.013 -0.041 0.014 0.335 0.553PC(15:0_20:3) -0.013 -0.035 0.009 0.265 0.903 -0.008 -0.021 0.006 0.269 0.520 -0.004 -0.015 0.007 0.478 0.747 -0.032 -0.059 -0.006 0.018 0.087Cer(d16:1/16:0) -0.003 -0.025 0.020 0.822 0.980 -0.008 -0.022 0.006 0.252 0.503 -0.004 -0.015 0.007 0.480 0.749 -0.014 -0.042 0.013 0.306 0.527PC(O-18:0/22:6) -0.008 -0.030 0.015 0.504 0.922 -0.015 -0.029 -0.001 0.043 0.306 -0.004 -0.015 0.007 0.484 0.752 -0.037 -0.065 -0.010 0.007 0.049PC(O-38:5) 0.004 -0.018 0.026 0.723 0.964 0.004 -0.009 0.018 0.528 0.735 -0.004 -0.015 0.007 0.483 0.752 -0.030 -0.056 -0.003 0.032 0.126PI(15-MHDA_18:2) & PI(17:0_18:2) ### Page 33 LPC(P-17:0) (b) -0.011 -0.033 0.011 0.330 0.922 -0.007 -0.021 0.007 0.307 0.549 -0.004 -0.014 0.007 0.487 0.756 -0.018 -0.045 0.009 0.195 0.408TG(O-54:3) [NL-18:1] 0.001 -0.021 0.023 0.946 0.995 -0.002 -0.016 0.012 0.766 0.881 0.004 -0.007 0.014 0.490 0.758 0.006 -0.021 0.034 0.647 0.807TG(48:3) [NL-14:0] -0.020 -0.042 0.002 0.077 0.903 -0.012 -0.026 0.002 0.083 0.356 -0.004 -0.014 0.007 0.494 0.759 -0.011 -0.039 0.016 0.420 0.634LPC(24:0) [sn2] 0.013 -0.009 0.035 0.241 0.903 0.002 -0.012 0.016 0.739 0.873 -0.004 -0.015 0.007 0.495 0.759 0.009 -0.019 0.036 0.549 0.729LPC(22:1) [sn2] 0.015 -0.006 0.037 0.164 0.903 -0.008 -0.022 0.005 0.232 0.488 -0.004 -0.015 0.007 0.493 0.759 -0.005 -0.032 0.023 0.740 0.874SM(d18:2/14:0) 0.001 -0.021 0.023 0.914 0.987 -0.001 -0.015 0.013 0.899 0.942 -0.004 -0.015 0.007 0.495 0.759 -0.036 -0.063 -0.009 0.008 0.053PE(15-MHDA_18:2) -0.012 -0.034 0.010 0.292 0.903 -0.017 -0.031 -0.003 0.017 0.273 -0.004 -0.015 0.007 0.496 0.760 -0.030 -0.057 -0.002 0.036 0.134LPC(20:5) [sn2] 0.008 -0.014 0.030 0.482 0.922 -0.011 -0.025 0.003 0.121 0.385 0.004 -0.007 0.015 0.498 0.761 -0.005 -0.033 0.022 0.713 0.847Cer(d18:1/19:0) -0.018 -0.040 0.005 0.124 0.903 -0.008 -0.021 0.006 0.273 0.521 -0.004 -0.015 0.007 0.500 0.762 -0.028 -0.055 0.000 0.049 0.161PC(33:0) (b) -0.012 -0.034 0.010 0.285 0.903 -0.009 -0.022 0.005 0.231 0.488 -0.004 -0.014 0.007 0.505 0.767 -0.047 -0.074 -0.019 0.001 0.016DG(16:0_18:2) -0.014 -0.036 0.008 0.205 0.903 -0.008 -0.022 0.005 0.230 0.488 -0.004 -0.014 0.007 0.510 0.767 -0.009 -0.036 0.019 0.534 0.719DG(18:1_20:4) -0.016 -0.038 0.006 0.155 0.903 -0.006 -0.020 0.008 0.386 0.626 0.004 -0.007 0.014 0.509 0.767 -0.003 -0.031 0.025 0.835 0.928PC(P-16:0/14:0) -0.007 -0.029 0.016 0.557 0.933 -0.007 -0.021 0.007 0.337 0.574 0.004 -0.007 0.014 0.509 0.767 -0.030 -0.057 -0.002 0.035 0.132SM(d18:2/24:0) 0.007 -0.015 0.029 0.554 0.933 0.004 -0.010 0.018 0.555 0.748 -0.004 -0.015 0.007 0.508 0.767 -0.019 -0.046 0.008 0.161 0.360PC(36:4) [+OH] -0.005 -0.027 0.017 0.633 0.958 0.005 -0.008 0.019 0.432 0.663 0.004 -0.007 0.014 0.508 0.767 -0.003 -0.031 0.024 0.803 0.910methyl-CE(18:0) -0.002 -0.025 0.021 0.856 0.981 0.003 -0.011 0.016 0.698 0.845 -0.004 -0.015 0.007 0.511 0.767 -0.013 -0.040 0.014 0.344 0.563SM(d16:1/19:0) -0.001 -0.024 0.021 0.928 0.995 -0.009 -0.023 0.005 0.190 0.454 -0.004 -0.014 0.007 0.508 0.767 -0.044 -0.071 -0.016 0.002 0.024FA(22:5) -0.003 -0.025 0.019 0.806 0.980 0.002 -0.011 0.016 0.742 0.874 0.004 -0.007 0.015 0.512 0.767 0.004 -0.024 0.031 0.795 0.905TG(54:6) [NL-20:4] -0.014 -0.036 0.008 0.217 0.903 -0.002 -0.016 0.012 0.778 0.884 -0.004 -0.014 0.007 0.513 0.768 -0.006 -0.034 0.022 0.675 0.823AC(22:6) 0.010 -0.012 0.032 0.376 0.922 -0.009 -0.023 0.005 0.212 0.475 0.004 -0.007 0.014 0.514 0.768 0.001 -0.027 0.028 0.954 0.969TG(48:1) [NL-18:1] -0.019 -0.041 0.003 0.083 0.903 -0.012 -0.026 0.001 0.081 0.356 0.004 -0.007 0.014 0.518 0.771 -0.003 -0.031 0.025 0.847 0.933PC(P-18:0/22:6) -0.002 -0.025 0.020 0.830 0.981 -0.010 -0.024 0.004 0.171 0.438 0.004 -0.007 0.014 0.519 0.771 -0.015 -0.042 0.012 0.281 0.505PE(P-20:0/20:4) -0.001 -0.023 0.021 0.939 0.995 0.001 -0.013 0.015 0.877 0.934 0.003 -0.007 0.014 0.528 0.782 -0.022 -0.049 0.006 0.131 0.315PC(P-38:5) (b) 0.001 -0.021 0.023 0.958 0.995 -0.011 -0.025 0.003 0.126 0.385 -0.003 -0.014 0.007 0.528 0.782 -0.028 -0.055 -0.002 0.038 0.138PI(18:0_22:5) (n3) -0.013 -0.035 0.009 0.232 0.903 -0.010 -0.024 0.004 0.164 0.432 -0.003 -0.014 0.007 0.529 0.782 -0.035 -0.062 -0.008 0.013 0.069Cer(m18:0/24:1) -0.019 -0.040 0.003 0.096 0.903 -0.013 -0.027 0.000 0.059 0.323 0.003 -0.007 0.014 0.537 0.791 -0.017 -0.044 0.010 0.230 0.439PC(P-16:0/16:0) -0.012 -0.034 0.010 0.305 0.903 -0.010 -0.024 0.003 0.144 0.406 -0.003 -0.014 0.007 0.538 0.791 -0.014 -0.042 0.013 0.306 0.527Cer(d19:1/26:0) 0.001 -0.022 0.024 0.928 0.995 -0.001 -0.016 0.014 0.892 0.940 0.003 -0.007 0.014 0.537 0.791 -0.004 -0.032 0.024 0.777 0.894TG(54:4) [NL-20:3] -0.014 -0.035 0.008 0.220 0.903 -0.014 -0.028 0.000 0.046 0.306 0.003 -0.007 0.014 0.540 0.791 -0.012 -0.040 0.016 0.405 0.620PE(16:0_16:1) -0.021 -0.043 0.001 0.066 0.903 -0.009 -0.023 0.004 0.187 0.454 0.003 -0.007 0.014 0.544 0.791 -0.012 -0.040 0.015 0.381 0.596PE(P-16:0/22:4) -0.023 -0.044 -0.001 0.044 0.903 0.008 -0.006 0.022 0.269 0.520 0.003 -0.007 0.014 0.543 0.791 -0.008 -0.035 0.020 0.574 0.745AC(16:0)-OH -0.007 -0.029 0.015 0.520 0.922 -0.009 -0.022 0.005 0.213 0.475 -0.003 -0.014 0.007 0.543 0.791 -0.033 -0.060 -0.006 0.017 0.084PE(O-16:0/18:2) -0.009 -0.031 0.014 0.451 0.922 0.003 -0.011 0.017 0.644 0.809 0.003 -0.007 0.014 0.541 0.791 -0.006 -0.033 0.021 0.659 0.814Hex2Cer(d16:1/24:1) -0.003 -0.025 0.020 0.814 0.980 -0.004 -0.018 0.009 0.530 0.735 -0.003 -0.014 0.007 0.545 0.792 -0.006 -0.034 0.021 0.658 0.814PC(18:0_22:5) (n6) -0.010 -0.032 0.012 0.386 0.922 0.002 -0.012 0.016 0.787 0.889 -0.003 -0.014 0.007 0.547 0.792 -0.014 -0.041 0.013 0.298 0.522DG(18:1_22:5) -0.006 -0.028 0.016 0.611 0.950 -0.016 -0.029 -0.002 0.025 0.285 0.003 -0.007 0.014 0.548 0.792 -0.014 -0.042 0.014 0.315 0.537TG(56:6) [NL-22:5] -0.008 -0.029 0.014 0.501 0.922 -0.019 -0.033 -0.006 0.005 0.259 0.003 -0.007 0.014 0.550 0.794 -0.019 -0.047 0.009 0.178 0.383Cer(d16:1/22:0) -0.005 -0.027 0.017 0.666 0.964 -0.007 -0.022 0.007 0.295 0.539 -0.003 -0.014 0.008 0.552 0.795 0.005 -0.022 0.033 0.702 0.845SM(44:2) -0.002 -0.024 0.020 0.872 0.981 -0.012 -0.026 0.002 0.087 0.356 0.003 -0.007 0.014 0.555 0.797 -0.031 -0.058 -0.004 0.025 0.106FA(22:4) -0.004 -0.026 0.018 0.718 0.964 0.004 -0.010 0.018 0.545 0.745 -0.003 -0.014 0.008 0.558 0.801 -0.012 -0.040 0.015 0.381 0.596LPC(20:5) [sn1] 0.008 -0.015 0.030 0.497 0.922 -0.012 -0.026 0.002 0.102 0.368 0.003 -0.008 0.014 0.565 0.810 -0.004 -0.032 0.024 0.777 0.894SM(43:2) (c) 0.002 -0.020 0.024 0.865 0.981 -0.009 -0.023 0.004 0.170 0.437 0.003 -0.008 0.014 0.566 0.810 -0.023 -0.050 0.003 0.084 0.226PC(O-34:2) -0.006 -0.028 0.016 0.612 0.950 0.003 -0.011 0.017 0.687 0.840 -0.003 -0.014 0.008 0.568 0.810 -0.014 -0.041 0.013 0.317 0.537TG(O-54:4) [NL-17:1] -0.015 -0.036 0.007 0.190 0.903 -0.001 -0.016 0.013 0.836 0.919 0.003 -0.008 0.014 0.573 0.813 0.018 -0.010 0.046 0.208 0.419PC(40:7) (a) -0.010 -0.032 0.012 0.386 0.922 -0.005 -0.018 0.009 0.521 0.727 -0.003 -0.014 0.008 0.574 0.813 -0.022 -0.050 0.005 0.109 0.276FA(22:6) 0.003 -0.019 0.025 0.816 0.980 -0.006 -0.020 0.007 0.361 0.599 0.003 -0.008 0.014 0.573 0.813 0.003 -0.025 0.031 0.837 0.928CA -0.001 -0.023 0.021 0.917 0.988 0.002 -0.012 0.016 0.760 0.881 0.003 -0.008 0.014 0.574 0.813 0.009 -0.018 0.037 0.507 0.702TG(54:2) [NL-18:0] -0.012 -0.033 0.010 0.289 0.903 -0.014 -0.028 0.000 0.044 0.306 0.003 -0.008 0.014 0.580 0.817 -0.001 -0.029 0.027 0.927 0.964CE(18:0) -0.006 -0.028 0.016 0.604 0.950 -0.002 -0.016 0.012 0.793 0.891 -0.003 -0.014 0.008 0.580 0.817 -0.041 -0.069 -0.014 0.003 0.035CE(24:4) 0.002 -0.021 0.024 0.879 0.981 0.010 -0.004 0.023 0.163 0.432 -0.003 -0.014 0.008 0.578 0.817 -0.011 -0.039 0.016 0.408 0.623LPC(22:6) [sn1] 0.001 -0.022 0.023 0.955 0.995 -0.015 -0.029 -0.001 0.034 0.298 -0.003 -0.014 0.008 0.581 0.817 -0.020 -0.048 0.008 0.155 0.352PC(15:0_20:4) -0.006 -0.027 0.016 0.613 0.950 0.000 -0.014 0.014 0.984 0.989 0.003 -0.008 0.014 0.583 0.817 -0.030 -0.057 -0.002 0.035 0.133TG(51:2) [NL-15:0] -0.012 -0.034 0.010 0.296 0.903 -0.019 -0.033 -0.006 0.006 0.259 -0.003 -0.014 0.008 0.586 0.820 -0.028 -0.056 0.000 0.053 0.170PE(36:0) -0.016 -0.038 0.005 0.140 0.903 -0.009 -0.023 0.004 0.185 0.453 -0.003 -0.014 0.008 0.588 0.820 -0.003 -0.031 0.025 0.840 0.928PC(P-18:0/20:4) -0.009 -0.031 0.012 0.398 0.922 0.002 -0.012 0.016 0.745 0.875 0.003 -0.008 0.014 0.588 0.820 -0.014 -0.041 0.013 0.320 0.539 ### Page 34 PI(18:0_18:1) -0.008 -0.030 0.014 0.456 0.922 -0.012 -0.027 0.002 0.083 0.356 -0.003 -0.014 0.008 0.591 0.821 -0.020 -0.047 0.007 0.147 0.337TG(53:2) [NL-18:1] -0.011 -0.033 0.011 0.339 0.922 -0.020 -0.033 -0.006 0.004 0.259 0.003 -0.008 0.014 0.592 0.821 -0.014 -0.042 0.014 0.317 0.537-0.002 -0.024 0.021 0.882 0.981 -0.005 -0.019 0.009 0.510 0.724 -0.003 -0.014 0.008 0.592 0.821 -0.048 -0.075 -0.021 0.001 0.013LPC(20:4) [sn2] -0.005 -0.027 0.017 0.659 0.960 -0.002 -0.016 0.012 0.827 0.913 -0.003 -0.014 0.008 0.595 0.823 -0.015 -0.043 0.013 0.285 0.509PC(33:0) (a) -0.015 -0.037 0.007 0.184 0.903 -0.012 -0.026 0.002 0.092 0.356 0.003 -0.008 0.014 0.599 0.825 -0.034 -0.061 -0.006 0.016 0.080Cer(m18:1/24:1) -0.018 -0.040 0.004 0.113 0.903 -0.012 -0.026 0.002 0.082 0.356 0.003 -0.008 0.014 0.599 0.825 -0.004 -0.031 0.023 0.774 0.893SHexCer(d18:1/24:0) 0.002 -0.020 0.025 0.839 0.981 -0.015 -0.028 -0.001 0.041 0.306 0.003 -0.008 0.014 0.600 0.825 -0.009 -0.037 0.020 0.548 0.729AC(14:1)-OH 0.001 -0.021 0.023 0.946 0.995 -0.002 -0.015 0.011 0.770 0.881 -0.003 -0.014 0.008 0.600 0.825 -0.024 -0.052 0.004 0.091 0.241TG(56:8) [NL-20:4] -0.012 -0.034 0.010 0.295 0.903 0.006 -0.008 0.020 0.425 0.657 -0.003 -0.014 0.008 0.604 0.828 0.009 -0.019 0.037 0.530 0.718LPE(P-18:0) -0.008 -0.030 0.014 0.490 0.922 -0.004 -0.018 0.010 0.590 0.764 -0.003 -0.014 0.008 0.603 0.828 -0.020 -0.047 0.008 0.159 0.358PC(32:2) -0.019 -0.041 0.003 0.092 0.903 -0.004 -0.018 0.010 0.599 0.771 -0.003 -0.014 0.008 0.617 0.830 -0.013 -0.040 0.014 0.358 0.577DG(16:0_20:4) -0.020 -0.042 0.002 0.070 0.903 -0.006 -0.019 0.008 0.404 0.643 0.003 -0.008 0.013 0.618 0.830 0.003 -0.024 0.031 0.818 0.920PA(34:1) -0.012 -0.034 0.010 0.299 0.903 -0.020 -0.034 -0.006 0.005 0.259 -0.003 -0.014 0.008 0.619 0.830 -0.002 -0.029 0.026 0.897 0.952PC(16:0_18:2) -0.007 -0.029 0.015 0.520 0.922 -0.012 -0.026 0.002 0.104 0.372 -0.003 -0.014 0.008 0.619 0.830 -0.034 -0.061 -0.006 0.016 0.080AC(20:3)-OH -0.007 -0.029 0.015 0.523 0.922 0.004 -0.010 0.018 0.583 0.763 -0.003 -0.014 0.008 0.614 0.830 -0.017 -0.043 0.010 0.219 0.429Cer(d19:1/24:0) 0.008 -0.014 0.031 0.465 0.922 -0.001 -0.015 0.013 0.870 0.932 0.003 -0.008 0.014 0.613 0.830 -0.010 -0.037 0.018 0.483 0.676PE(P-18:0/22:5) (n6) -0.007 -0.029 0.015 0.515 0.922 0.007 -0.007 0.021 0.336 0.574 0.003 -0.008 0.013 0.610 0.830 0.009 -0.018 0.035 0.520 0.709TG(54:7) [NL-20:5] -0.007 -0.030 0.015 0.523 0.922 -0.009 -0.023 0.004 0.185 0.453 0.003 -0.008 0.014 0.614 0.830 0.005 -0.022 0.033 0.706 0.845LPC(19:0) [sn2] (a) 0.005 -0.017 0.027 0.651 0.960 -0.007 -0.021 0.007 0.316 0.557 -0.003 -0.014 0.008 0.610 0.830 -0.008 -0.035 0.020 0.588 0.756PC(17:0_22:6) 0.005 -0.018 0.027 0.690 0.964 -0.014 -0.029 0.000 0.046 0.306 -0.003 -0.014 0.008 0.609 0.830 -0.039 -0.067 -0.012 0.005 0.047SM(d19:1/24:1) 0.005 -0.018 0.027 0.676 0.964 -0.012 -0.026 0.002 0.097 0.361 0.003 -0.008 0.013 0.616 0.830 -0.026 -0.054 0.001 0.063 0.184PC(15-MHDA_22:6) 0.002 -0.020 0.025 0.845 0.981 -0.015 -0.029 -0.001 0.037 0.301 0.003 -0.008 0.014 0.620 0.830 -0.037 -0.065 -0.009 0.010 0.059SM(37:1) 0.000 -0.023 0.022 0.975 0.995 -0.006 -0.020 0.008 0.411 0.646 -0.003 -0.013 0.008 0.612 0.830 -0.042 -0.069 -0.014 0.003 0.035LPC(14:0) [sn2] -0.012 -0.034 0.011 0.311 0.910 -0.010 -0.023 0.004 0.167 0.433 -0.003 -0.013 0.008 0.622 0.831 -0.017 -0.045 0.010 0.220 0.429PC(14:0_16:0) -0.017 -0.039 0.005 0.123 0.903 -0.009 -0.023 0.004 0.184 0.453 -0.003 -0.013 0.008 0.626 0.831 -0.026 -0.054 0.001 0.058 0.177PI(34:1) -0.012 -0.034 0.010 0.296 0.903 -0.005 -0.019 0.009 0.505 0.722 0.003 -0.008 0.014 0.630 0.831 -0.008 -0.035 0.020 0.587 0.756methyl-DE(18:2) 0.015 -0.007 0.037 0.188 0.903 0.004 -0.010 0.018 0.584 0.763 -0.003 -0.014 0.008 0.625 0.831 0.000 -0.027 0.028 0.974 0.982LPC(15:0) [sn1] -0.011 -0.033 0.012 0.348 0.922 -0.011 -0.025 0.003 0.114 0.382 -0.003 -0.013 0.008 0.629 0.831 -0.027 -0.054 0.001 0.060 0.179PC(28:0) -0.009 -0.031 0.013 0.418 0.922 -0.007 -0.021 0.007 0.318 0.557 -0.003 -0.013 0.008 0.630 0.831 -0.026 -0.053 0.001 0.061 0.183HexCer(d16:1/24:0) 0.009 -0.013 0.031 0.424 0.922 -0.002 -0.016 0.012 0.766 0.881 -0.003 -0.014 0.008 0.627 0.831 0.006 -0.022 0.033 0.694 0.840PS(40:6) 0.008 -0.014 0.031 0.456 0.922 -0.017 -0.031 -0.003 0.020 0.273 0.003 -0.008 0.014 0.630 0.831 0.003 -0.025 0.031 0.842 0.928PC(P-18:0/22:5) -0.010 -0.032 0.013 0.401 0.922 -0.008 -0.022 0.006 0.259 0.509 -0.003 -0.013 0.008 0.638 0.835 -0.038 -0.065 -0.012 0.005 0.044PS(38:4) 0.009 -0.014 0.031 0.440 0.922 -0.010 -0.024 0.003 0.132 0.395 -0.003 -0.013 0.008 0.637 0.835 -0.010 -0.038 0.017 0.453 0.657FA(18:0) -0.005 -0.027 0.018 0.680 0.964 -0.002 -0.015 0.011 0.766 0.881 0.003 -0.008 0.013 0.637 0.835 0.008 -0.017 0.034 0.535 0.719CE(20:0) -0.003 -0.026 0.019 0.764 0.969 0.007 -0.006 0.021 0.303 0.546 -0.003 -0.013 0.008 0.635 0.835 -0.012 -0.039 0.015 0.380 0.596S1P(d16:1) 0.000 -0.023 0.022 0.980 0.995 -0.006 -0.020 0.008 0.384 0.624 -0.003 -0.013 0.008 0.639 0.835 -0.010 -0.038 0.018 0.471 0.665PI(37:6) 0.005 -0.017 0.028 0.638 0.960 -0.010 -0.024 0.004 0.177 0.447 0.003 -0.008 0.013 0.642 0.837 -0.038 -0.067 -0.010 0.007 0.049FA(16:0) -0.004 -0.026 0.019 0.753 0.969 0.003 -0.011 0.016 0.717 0.855 0.003 -0.008 0.013 0.644 0.837 0.000 -0.027 0.027 0.988 0.992PE(P-18:1/18:3) 0.000 -0.022 0.023 0.979 0.995 -0.002 -0.016 0.012 0.765 0.881 -0.003 -0.013 0.008 0.644 0.837 -0.005 -0.032 0.022 0.737 0.872CE(22:6) 0.008 -0.014 0.030 0.494 0.922 -0.003 -0.016 0.011 0.715 0.855 -0.002 -0.013 0.008 0.650 0.841 -0.029 -0.057 -0.001 0.042 0.147PS(36:1) -0.007 -0.029 0.015 0.548 0.929 -0.014 -0.028 0.000 0.045 0.306 0.003 -0.008 0.013 0.650 0.841 -0.001 -0.029 0.026 0.928 0.964SM(d17:1/14:0) -0.004 -0.027 0.018 0.709 0.964 -0.005 -0.019 0.009 0.466 0.686 -0.002 -0.013 0.008 0.649 0.841 -0.033 -0.060 -0.005 0.021 0.093LPC(20:3) [sn1] -0.012 -0.034 0.010 0.291 0.903 -0.012 -0.025 0.002 0.092 0.356 -0.002 -0.013 0.008 0.653 0.842 -0.019 -0.046 0.009 0.180 0.386CE(24:6) 0.004 -0.018 0.026 0.740 0.964 -0.005 -0.019 0.009 0.480 0.697 -0.003 -0.014 0.008 0.652 0.842 -0.006 -0.034 0.021 0.656 0.814PC(O-18:0/20:4) -0.009 -0.031 0.013 0.403 0.922 0.000 -0.014 0.014 0.997 0.998 -0.002 -0.013 0.008 0.658 0.846 -0.033 -0.060 -0.006 0.016 0.080PC(18:0_18:1) -0.010 -0.032 0.012 0.364 0.922 -0.015 -0.029 -0.001 0.034 0.298 -0.002 -0.013 0.008 0.658 0.846 -0.032 -0.060 -0.005 0.022 0.097PE(18:0_22:5) (n3) -0.012 -0.034 0.009 0.262 0.903 -0.014 -0.027 0.000 0.052 0.317 -0.002 -0.013 0.008 0.662 0.847 -0.021 -0.048 0.007 0.141 0.330TG(50:1) [NL-14:0] -0.016 -0.038 0.006 0.163 0.903 -0.010 -0.024 0.003 0.134 0.396 0.002 -0.008 0.013 0.663 0.847 0.003 -0.026 0.031 0.862 0.937Cer(d18:1/24:0) -0.002 -0.024 0.020 0.881 0.981 0.003 -0.011 0.017 0.670 0.831 -0.002 -0.013 0.008 0.661 0.847 -0.007 -0.034 0.021 0.639 0.800Cer(m18:0/20:0) -0.018 -0.040 0.004 0.105 0.903 -0.013 -0.027 0.001 0.062 0.332 0.002 -0.008 0.013 0.666 0.850 -0.012 -0.040 0.015 0.373 0.590LPC(17:1) [sn1] (b) -0.012 -0.035 0.011 0.300 0.903 -0.012 -0.026 0.002 0.084 0.356 -0.002 -0.013 0.008 0.675 0.853 -0.031 -0.059 -0.003 0.029 0.118PE(P-18:0/22:4) -0.013 -0.035 0.009 0.241 0.903 0.008 -0.006 0.022 0.274 0.521 -0.002 -0.013 0.008 0.675 0.853 -0.015 -0.042 0.012 0.287 0.509TG(48:2) [NL-14:0] -0.019 -0.041 0.003 0.092 0.903 -0.013 -0.026 0.001 0.069 0.347 -0.002 -0.013 0.008 0.674 0.853 -0.009 -0.037 0.019 0.519 0.709PE(17:0_20:4) -0.010 -0.032 0.012 0.372 0.922 -0.013 -0.027 0.001 0.072 0.350 -0.002 -0.013 0.008 0.676 0.853 -0.029 -0.057 -0.001 0.042 0.147SM(d18:1/17:0) & SM(d17:1/18:0) ### Page 35 SM(d17:1/16:0) -0.004 -0.026 0.018 0.738 0.964 0.000 -0.014 0.014 0.957 0.976 -0.002 -0.013 0.009 0.675 0.853 -0.028 -0.056 -0.001 0.044 0.150LPC(22:6) [+OH] 0.002 -0.021 0.024 0.883 0.981 -0.005 -0.020 0.009 0.445 0.672 -0.002 -0.013 0.009 0.677 0.853 -0.001 -0.029 0.027 0.943 0.966LPI(20:4) [sn1] -0.001 -0.023 0.021 0.961 0.995 -0.002 -0.016 0.013 0.826 0.913 0.002 -0.008 0.013 0.677 0.853 0.006 -0.021 0.033 0.669 0.8180.000 -0.022 0.022 0.990 0.996 -0.001 -0.015 0.013 0.904 0.943 0.002 -0.008 0.013 0.670 0.853 -0.014 -0.041 0.013 0.318 0.538DG(16:1_18:1) -0.018 -0.040 0.004 0.107 0.903 -0.016 -0.030 -0.003 0.020 0.273 -0.002 -0.013 0.008 0.681 0.855 -0.029 -0.056 -0.001 0.042 0.147CE(20:5) 0.015 -0.007 0.037 0.192 0.903 0.001 -0.013 0.015 0.875 0.934 0.002 -0.008 0.013 0.681 0.855 -0.010 -0.038 0.018 0.475 0.668methyl-DE(18:1) 0.016 -0.006 0.038 0.159 0.903 -0.001 -0.015 0.013 0.852 0.929 0.002 -0.009 0.013 0.684 0.855 0.003 -0.025 0.030 0.839 0.928dimethyl-CE(18:1) 0.011 -0.011 0.033 0.329 0.922 -0.005 -0.019 0.009 0.466 0.686 0.002 -0.009 0.013 0.683 0.855 -0.016 -0.044 0.012 0.260 0.479PE(O-18:1/18:2) -0.004 -0.027 0.018 0.699 0.964 0.008 -0.006 0.022 0.290 0.536 0.002 -0.009 0.013 0.685 0.855 -0.007 -0.035 0.020 0.603 0.767PE(18:0_18:2) -0.013 -0.035 0.009 0.243 0.903 -0.012 -0.026 0.002 0.095 0.360 -0.002 -0.013 0.009 0.689 0.858 0.000 -0.027 0.028 0.979 0.985methyl-CE(20:4) 0.013 -0.010 0.035 0.268 0.903 0.009 -0.006 0.023 0.233 0.490 0.002 -0.009 0.013 0.694 0.863 -0.006 -0.033 0.022 0.685 0.830PE(15-MHDA_20:4) -0.015 -0.037 0.007 0.176 0.903 -0.010 -0.024 0.004 0.145 0.406 0.002 -0.009 0.013 0.695 0.864 -0.020 -0.048 0.007 0.146 0.337PI(38:6) -0.006 -0.028 0.016 0.601 0.950 -0.012 -0.026 0.002 0.092 0.356 -0.002 -0.013 0.009 0.697 0.864 -0.017 -0.045 0.010 0.220 0.430CE(17:1) -0.005 -0.027 0.017 0.652 0.960 -0.008 -0.022 0.005 0.241 0.495 -0.002 -0.013 0.009 0.704 0.872 -0.038 -0.066 -0.011 0.007 0.048PC(18:0_22:4) -0.015 -0.037 0.006 0.162 0.903 0.001 -0.013 0.015 0.903 0.943 -0.002 -0.013 0.009 0.707 0.873 -0.019 -0.046 0.008 0.164 0.366LPE(22:6) [sn1] -0.011 -0.033 0.012 0.346 0.922 -0.012 -0.026 0.001 0.082 0.356 -0.002 -0.013 0.009 0.707 0.873 -0.012 -0.040 0.015 0.372 0.590PC(33:2) -0.010 -0.032 0.012 0.383 0.922 -0.007 -0.021 0.007 0.347 0.589 -0.002 -0.013 0.009 0.710 0.873 -0.031 -0.058 -0.004 0.026 0.107PE(18:1_18:1) 0.000 -0.022 0.022 0.988 0.996 -0.013 -0.027 0.000 0.059 0.323 -0.002 -0.013 0.009 0.710 0.873 0.009 -0.019 0.037 0.512 0.706LPC(26:0) [sn2] 0.006 -0.016 0.029 0.569 0.933 -0.007 -0.021 0.007 0.322 0.560 -0.002 -0.013 0.009 0.715 0.878 -0.009 -0.037 0.018 0.517 0.709PE(P-18:1/20:5) (b) 0.008 -0.014 0.030 0.475 0.922 -0.008 -0.022 0.006 0.292 0.536 0.002 -0.009 0.013 0.722 0.885 -0.022 -0.049 0.006 0.119 0.293DG(18:0_20:4) -0.017 -0.039 0.005 0.124 0.903 -0.013 -0.027 0.000 0.053 0.317 0.002 -0.009 0.013 0.726 0.888 -0.001 -0.029 0.027 0.948 0.968TG(52:5) [NL-20:4] -0.020 -0.042 0.002 0.076 0.903 -0.006 -0.020 0.007 0.351 0.592 0.002 -0.009 0.012 0.739 0.892 -0.002 -0.030 0.026 0.901 0.952LPI(18:1) [sn2] 0.012 -0.010 0.034 0.287 0.903 0.001 -0.013 0.014 0.903 0.943 -0.002 -0.013 0.009 0.734 0.892 -0.002 -0.028 0.025 0.908 0.955CE(14:0) -0.009 -0.031 0.014 0.450 0.922 -0.013 -0.027 0.001 0.065 0.338 -0.002 -0.013 0.009 0.738 0.892 -0.021 -0.049 0.007 0.137 0.323DG(16:0_22:5) -0.011 -0.033 0.011 0.333 0.922 -0.015 -0.028 -0.002 0.028 0.285 -0.002 -0.013 0.009 0.735 0.892 -0.017 -0.044 0.011 0.229 0.439FA(20:5) 0.010 -0.012 0.032 0.371 0.922 -0.013 -0.027 0.001 0.066 0.338 0.002 -0.009 0.013 0.738 0.892 -0.001 -0.028 0.027 0.957 0.970Cer(d17:1/23:0) -0.007 -0.029 0.015 0.536 0.923 -0.005 -0.020 0.009 0.450 0.674 -0.002 -0.013 0.009 0.739 0.892 -0.017 -0.044 0.010 0.225 0.434PC(36:6) (a) 0.004 -0.019 0.026 0.744 0.964 -0.009 -0.023 0.005 0.199 0.460 -0.002 -0.013 0.009 0.740 0.892 -0.019 -0.046 0.008 0.175 0.378PC(15:0_22:6) 0.001 -0.021 0.023 0.942 0.995 -0.012 -0.026 0.002 0.100 0.366 0.002 -0.009 0.013 0.732 0.892 -0.026 -0.055 0.002 0.065 0.186FA(18:1) -0.001 -0.023 0.022 0.944 0.995 0.001 -0.013 0.015 0.872 0.932 -0.002 -0.013 0.009 0.740 0.892 -0.017 -0.045 0.011 0.231 0.440Cer(d18:1/26:0) -0.012 -0.035 0.010 0.286 0.903 0.005 -0.009 0.019 0.503 0.720 -0.002 -0.013 0.009 0.743 0.893 -0.015 -0.043 0.012 0.270 0.495PE(15-MHDA_22:6) -0.007 -0.030 0.015 0.520 0.922 -0.014 -0.028 0.000 0.044 0.306 0.002 -0.009 0.013 0.742 0.893 -0.014 -0.042 0.014 0.327 0.545LPI(18:0) [sn2] -0.010 -0.032 0.012 0.371 0.922 -0.005 -0.019 0.010 0.530 0.735 -0.002 -0.013 0.009 0.745 0.894 -0.002 -0.029 0.026 0.896 0.952TG(48:2) [NL-18:2] -0.022 -0.043 0.000 0.051 0.903 -0.010 -0.024 0.003 0.142 0.406 -0.002 -0.012 0.009 0.748 0.896 -0.005 -0.034 0.023 0.707 0.845PI(18:0_22:4) -0.026 -0.047 -0.004 0.020 0.903 -0.012 -0.026 0.002 0.103 0.371 -0.002 -0.013 0.009 0.750 0.897 -0.019 -0.046 0.008 0.167 0.371TG(56:8) [NL-20:5] 0.003 -0.019 0.025 0.785 0.973 -0.007 -0.021 0.007 0.331 0.572 0.002 -0.009 0.013 0.751 0.898 0.003 -0.025 0.030 0.853 0.933PE(P-18:1/20:3) (b) -0.012 -0.034 0.010 0.304 0.903 -0.004 -0.018 0.010 0.576 0.758 -0.002 -0.013 0.009 0.753 0.898 -0.031 -0.057 -0.004 0.025 0.106PC(44:12) 0.009 -0.013 0.031 0.413 0.922 -0.008 -0.022 0.006 0.273 0.521 0.002 -0.009 0.013 0.758 0.902 0.003 -0.026 0.031 0.851 0.933TG(54:2) [NL-20:1] -0.009 -0.031 0.013 0.406 0.922 -0.017 -0.031 -0.004 0.014 0.273 0.002 -0.009 0.012 0.765 0.909 -0.007 -0.035 0.021 0.632 0.794PE(O-18:0/22:5) -0.008 -0.030 0.014 0.491 0.922 0.003 -0.011 0.017 0.646 0.811 0.002 -0.009 0.012 0.771 0.915 -0.020 -0.047 0.007 0.141 0.330PA(40:6) 0.000 -0.021 0.022 0.984 0.996 -0.007 -0.022 0.007 0.318 0.557 -0.002 -0.012 0.009 0.774 0.917 -0.007 -0.036 0.023 0.657 0.814LPC(15:0) [sn2] -0.011 -0.033 0.011 0.335 0.922 -0.011 -0.025 0.002 0.100 0.366 -0.002 -0.012 0.009 0.777 0.919 -0.027 -0.055 0.001 0.055 0.173LPI(20:4) [sn2] -0.010 -0.032 0.012 0.363 0.922 -0.003 -0.017 0.011 0.684 0.840 0.002 -0.009 0.012 0.779 0.921 -0.010 -0.037 0.018 0.486 0.678FA(17:0) -0.005 -0.027 0.018 0.694 0.964 -0.006 -0.021 0.009 0.409 0.645 -0.002 -0.013 0.010 0.781 0.921 0.001 -0.027 0.029 0.958 0.970TG(50:4) [NL-20:4] -0.020 -0.042 0.002 0.075 0.903 -0.008 -0.021 0.006 0.273 0.521 0.001 -0.009 0.012 0.783 0.921 0.006 -0.022 0.034 0.682 0.827SM(d18:2/23:0) 0.002 -0.020 0.024 0.854 0.981 0.000 -0.014 0.014 0.996 0.998 -0.002 -0.012 0.009 0.783 0.921 -0.024 -0.051 0.003 0.081 0.221PC(16:0_22:6) 0.002 -0.020 0.024 0.867 0.981 -0.013 -0.027 0.002 0.084 0.356 0.002 -0.009 0.012 0.786 0.922 -0.023 -0.052 0.005 0.102 0.261Cer(d19:1/16:0) 0.001 -0.021 0.024 0.902 0.985 -0.006 -0.020 0.008 0.390 0.631 -0.001 -0.012 0.009 0.789 0.925 -0.016 -0.044 0.012 0.272 0.498TG(51:2) [NL-17:1] -0.017 -0.039 0.005 0.126 0.903 -0.019 -0.033 -0.005 0.006 0.259 0.001 -0.009 0.012 0.792 0.925 -0.023 -0.051 0.004 0.099 0.256CE(24:5) 0.003 -0.019 0.025 0.777 0.973 -0.001 -0.015 0.012 0.832 0.917 -0.001 -0.012 0.009 0.791 0.925 -0.013 -0.041 0.014 0.352 0.572Cer(d19:1/22:0) 0.004 -0.018 0.027 0.708 0.964 -0.004 -0.018 0.009 0.532 0.737 -0.001 -0.012 0.009 0.794 0.926 -0.027 -0.055 0.000 0.048 0.157TG(48:2) [NL-16:1] -0.021 -0.044 0.001 0.057 0.903 -0.015 -0.028 -0.001 0.036 0.301 -0.001 -0.012 0.009 0.795 0.927 -0.016 -0.044 0.011 0.243 0.457DG(14:0_16:0) -0.015 -0.037 0.007 0.186 0.903 -0.011 -0.024 0.003 0.121 0.385 0.001 -0.009 0.012 0.797 0.927 0.006 -0.021 0.033 0.661 0.814Cer(d19:1/24:1) -0.002 -0.025 0.020 0.857 0.981 -0.017 -0.031 -0.003 0.018 0.273 -0.001 -0.012 0.009 0.801 0.930 -0.030 -0.057 -0.002 0.035 0.132SM(d16:1/23:0) & SM(d17:1/22:0) ### Page 36 PE(O-16:0/22:4) -0.016 -0.038 0.006 0.163 0.903 0.009 -0.005 0.023 0.194 0.454 0.001 -0.009 0.012 0.807 0.932 -0.006 -0.033 0.021 0.669 0.818SM(d16:1/24:1) -0.004 -0.027 0.018 0.694 0.964 -0.012 -0.026 0.002 0.089 0.356 0.001 -0.009 0.012 0.805 0.932 -0.027 -0.055 0.001 0.057 0.173PE(P-20:0/22:6) 0.004 -0.019 0.026 0.747 0.964 -0.012 -0.026 0.003 0.112 0.382 0.001 -0.010 0.012 0.806 0.932 -0.026 -0.054 0.002 0.069 0.195TG(52:2) [NL-18:2] -0.025 -0.046 -0.004 0.023 0.903 -0.007 -0.021 0.006 0.293 0.536 0.001 -0.009 0.012 0.810 0.934 0.005 -0.022 0.033 0.712 0.847PE(16:0_22:6) -0.002 -0.024 0.020 0.848 0.981 -0.012 -0.026 0.001 0.075 0.355 0.001 -0.009 0.012 0.809 0.934 -0.012 -0.040 0.016 0.406 0.620dimethyl-CE(18:2) 0.012 -0.010 0.034 0.287 0.903 0.002 -0.012 0.016 0.771 0.881 -0.001 -0.012 0.010 0.814 0.935 -0.011 -0.038 0.017 0.456 0.660SM(43:2) (b) -0.007 -0.029 0.015 0.561 0.933 -0.015 -0.029 -0.001 0.034 0.298 0.001 -0.009 0.012 0.813 0.935 -0.038 -0.065 -0.011 0.007 0.048Cer(d20:1/24:1) -0.012 -0.034 0.010 0.273 0.903 -0.012 -0.026 0.002 0.089 0.356 0.001 -0.010 0.012 0.817 0.937 -0.023 -0.050 0.005 0.107 0.272PC(31:0) (b) -0.008 -0.030 0.014 0.491 0.922 -0.007 -0.021 0.007 0.320 0.559 0.001 -0.009 0.012 0.821 0.940 -0.036 -0.063 -0.008 0.011 0.064CE(16:1) -0.008 -0.030 0.015 0.505 0.922 -0.011 -0.024 0.003 0.127 0.385 -0.001 -0.012 0.010 0.824 0.940 -0.018 -0.045 0.010 0.209 0.419TG(50:2) [NL-14:0] -0.002 -0.024 0.020 0.853 0.981 -0.017 -0.031 -0.003 0.015 0.273 -0.001 -0.012 0.010 0.825 0.940 -0.016 -0.045 0.013 0.276 0.500TG(56:6) [NL-20:4] -0.002 -0.024 0.020 0.850 0.981 0.002 -0.012 0.016 0.807 0.899 0.001 -0.010 0.012 0.823 0.940 -0.004 -0.032 0.024 0.771 0.892PE(P-18:0/18:2) -0.008 -0.030 0.014 0.500 0.922 0.004 -0.010 0.018 0.570 0.752 -0.001 -0.012 0.010 0.827 0.941 -0.008 -0.035 0.019 0.571 0.745FA(14:0) 0.008 -0.014 0.030 0.460 0.922 0.001 -0.013 0.015 0.891 0.939 -0.001 -0.012 0.010 0.829 0.942 -0.012 -0.040 0.016 0.401 0.617PI(18:0_20:3) (b) -0.016 -0.038 0.007 0.170 0.903 -0.026 -0.040 -0.012 0.000 0.092 -0.001 -0.012 0.010 0.832 0.943 -0.038 -0.066 -0.011 0.007 0.048-0.013 -0.035 0.009 0.259 0.903 -0.011 -0.025 0.003 0.134 0.396 -0.001 -0.012 0.010 0.831 0.943 -0.015 -0.042 0.013 0.296 0.520dimethyl-CE(20:4) 0.012 -0.011 0.034 0.305 0.903 0.005 -0.009 0.019 0.458 0.682 -0.001 -0.012 0.010 0.837 0.944 -0.017 -0.045 0.010 0.214 0.422Cer(m18:1/20:0) -0.021 -0.043 0.001 0.064 0.903 -0.010 -0.023 0.004 0.161 0.432 0.001 -0.010 0.012 0.838 0.944 -0.011 -0.038 0.016 0.432 0.640TG(48:3) [NL-18:3] -0.020 -0.042 0.002 0.071 0.903 -0.009 -0.023 0.004 0.182 0.452 -0.001 -0.012 0.010 0.837 0.944 0.002 -0.026 0.030 0.870 0.943LPC(22:6) [sn2] 0.003 -0.019 0.026 0.765 0.969 -0.014 -0.028 0.000 0.045 0.306 -0.001 -0.012 0.010 0.837 0.944 -0.014 -0.042 0.014 0.321 0.540PC(34:2) [+OH] -0.013 -0.035 0.009 0.248 0.903 -0.002 -0.016 0.011 0.766 0.881 0.001 -0.010 0.012 0.844 0.948 0.004 -0.023 0.032 0.762 0.891PC(P-18:1/22:6) 0.002 -0.020 0.024 0.871 0.981 -0.012 -0.026 0.002 0.088 0.356 -0.001 -0.012 0.010 0.843 0.948 -0.028 -0.055 -0.001 0.044 0.150PE(20:0_20:4) -0.016 -0.038 0.007 0.167 0.903 -0.005 -0.018 0.009 0.512 0.724 0.001 -0.010 0.012 0.851 0.954 0.011 -0.016 0.038 0.439 0.644PC(32:1) -0.020 -0.042 0.002 0.075 0.903 -0.011 -0.025 0.003 0.113 0.382 -0.001 -0.012 0.010 0.860 0.962 -0.027 -0.054 0.001 0.056 0.173DG(18:2_20:4) -0.015 -0.037 0.007 0.183 0.903 0.002 -0.012 0.016 0.790 0.891 -0.001 -0.012 0.010 0.862 0.962 -0.001 -0.029 0.026 0.920 0.963LPE(22:6) [sn2] -0.010 -0.032 0.013 0.402 0.922 -0.012 -0.025 0.002 0.088 0.356 -0.001 -0.012 0.010 0.862 0.962 -0.011 -0.039 0.016 0.412 0.628SM(d18:1/24:1) -0.012 -0.034 0.010 0.298 0.903 -0.011 -0.025 0.003 0.125 0.385 -0.001 -0.012 0.010 0.884 0.964 -0.029 -0.056 -0.001 0.041 0.146SM(37:2) -0.012 -0.034 0.010 0.292 0.903 0.000 -0.015 0.014 0.950 0.972 0.001 -0.010 0.012 0.883 0.964 -0.016 -0.043 0.011 0.243 0.456PI(16:0_20:4) -0.024 -0.046 -0.002 0.033 0.903 -0.004 -0.018 0.010 0.554 0.748 -0.001 -0.012 0.010 0.878 0.964 -0.015 -0.042 0.013 0.294 0.518TG(51:2) [NL-17:0] -0.019 -0.041 0.002 0.082 0.903 -0.016 -0.029 -0.002 0.023 0.285 0.001 -0.010 0.011 0.895 0.964 -0.012 -0.040 0.016 0.392 0.609DG(16:0_16:1) -0.020 -0.043 0.002 0.071 0.903 -0.011 -0.025 0.002 0.110 0.380 -0.001 -0.011 0.010 0.895 0.964 -0.011 -0.038 0.016 0.434 0.641methyl-CE(22:6) 0.018 -0.005 0.040 0.120 0.903 0.000 -0.013 0.014 0.973 0.983 -0.001 -0.011 0.010 0.892 0.964 -0.009 -0.037 0.019 0.535 0.719Cer(d16:1/23:0) -0.012 -0.034 0.010 0.291 0.903 -0.011 -0.025 0.003 0.114 0.382 -0.001 -0.012 0.010 0.887 0.964 -0.007 -0.035 0.020 0.601 0.765dimethyl-CE(22:6) 0.014 -0.009 0.036 0.231 0.903 0.000 -0.014 0.014 0.963 0.979 0.001 -0.010 0.012 0.891 0.964 -0.005 -0.033 0.022 0.708 0.845PG(36:2) -0.019 -0.041 0.004 0.102 0.903 -0.009 -0.023 0.004 0.166 0.432 -0.001 -0.012 0.010 0.883 0.964 0.004 -0.024 0.032 0.770 0.892PC(16:0_18:1) -0.011 -0.032 0.011 0.348 0.922 -0.012 -0.026 0.002 0.095 0.360 -0.001 -0.012 0.010 0.888 0.964 -0.039 -0.067 -0.011 0.006 0.048CE(17:0) -0.009 -0.031 0.013 0.437 0.922 -0.006 -0.020 0.007 0.359 0.598 -0.001 -0.012 0.010 0.869 0.964 -0.038 -0.065 -0.011 0.007 0.048PC(15-MHDA_18:2) -0.009 -0.031 0.013 0.413 0.922 -0.013 -0.027 0.001 0.065 0.338 -0.001 -0.012 0.010 0.889 0.964 -0.031 -0.058 -0.004 0.027 0.111TG(52:2) [NL-16:0] -0.008 -0.030 0.014 0.466 0.922 -0.020 -0.033 -0.006 0.006 0.259 -0.001 -0.012 0.010 0.892 0.964 -0.030 -0.058 -0.002 0.036 0.134PC(P-35:2) (b) -0.008 -0.030 0.014 0.481 0.922 -0.005 -0.018 0.009 0.509 0.724 -0.001 -0.012 0.010 0.878 0.964 -0.010 -0.037 0.016 0.447 0.652AC(17:0) (a) -0.006 -0.028 0.016 0.612 0.950 -0.017 -0.031 -0.004 0.012 0.273 -0.001 -0.012 0.010 0.878 0.964 -0.031 -0.057 -0.004 0.025 0.106PE(P-18:0/18:3) -0.006 -0.028 0.017 0.627 0.954 -0.002 -0.016 0.012 0.768 0.881 -0.001 -0.012 0.010 0.888 0.964 -0.007 -0.035 0.022 0.651 0.811SM(d17:1/24:1) -0.005 -0.027 0.017 0.653 0.960 -0.014 -0.028 0.000 0.046 0.306 -0.001 -0.011 0.010 0.893 0.964 -0.033 -0.060 -0.005 0.020 0.091PE(16:0_20:5) -0.004 -0.026 0.018 0.714 0.964 -0.016 -0.030 -0.002 0.022 0.273 0.001 -0.010 0.012 0.886 0.964 -0.009 -0.037 0.018 0.508 0.702TG(O-54:4) [NL-18:2] -0.004 -0.026 0.018 0.732 0.964 0.011 -0.003 0.024 0.130 0.390 0.001 -0.010 0.012 0.877 0.964 0.008 -0.020 0.035 0.574 0.745FA(20:3) -0.004 -0.026 0.018 0.707 0.964 0.000 -0.014 0.014 0.972 0.983 -0.001 -0.012 0.010 0.891 0.964 -0.003 -0.030 0.025 0.853 0.933PC(14:0_22:6) -0.003 -0.026 0.019 0.786 0.973 -0.011 -0.025 0.002 0.106 0.373 -0.001 -0.012 0.010 0.892 0.964 -0.018 -0.046 0.009 0.197 0.409PC(16:0_20:4) 0.002 -0.020 0.024 0.864 0.981 -0.001 -0.015 0.013 0.898 0.942 -0.001 -0.012 0.010 0.889 0.964 -0.032 -0.060 -0.003 0.030 0.120PE(P-18:1/18:2) (a) -0.002 -0.025 0.020 0.839 0.981 0.005 -0.009 0.019 0.459 0.682 0.001 -0.010 0.012 0.887 0.964 -0.014 -0.041 0.014 0.332 0.550LPI(18:1) [sn1] 0.002 -0.020 0.024 0.881 0.981 -0.014 -0.028 0.000 0.054 0.317 -0.001 -0.012 0.010 0.869 0.964 0.012 -0.015 0.039 0.383 0.598TG(48:2) [NL-14:1] -0.020 -0.042 0.003 0.083 0.903 -0.017 -0.030 -0.003 0.017 0.273 -0.001 -0.011 0.010 0.903 0.969 -0.017 -0.045 0.010 0.222 0.430PC(P-38:5) (a) -0.004 -0.026 0.018 0.727 0.964 -0.003 -0.017 0.011 0.643 0.809 -0.001 -0.012 0.010 0.902 0.969 -0.025 -0.052 0.002 0.071 0.200TG(56:7) [NL-22:5] -0.005 -0.027 0.017 0.669 0.964 -0.011 -0.025 0.003 0.113 0.382 -0.001 -0.011 0.010 0.903 0.969 -0.015 -0.043 0.013 0.288 0.509PC(33:1) -0.017 -0.039 0.005 0.139 0.903 -0.016 -0.029 -0.002 0.028 0.285 -0.001 -0.012 0.010 0.906 0.971 -0.039 -0.067 -0.012 0.005 0.044PI(15-MHDA_18:1) & PI(17:0_18:1) ### Page 37 -0.025 -0.047 -0.004 0.023 0.903 -0.009 -0.023 0.005 0.192 0.454 -0.001 -0.011 0.010 0.910 0.972 -0.029 -0.057 -0.002 0.037 0.136PC(P-16:0/18:2) -0.010 -0.032 0.012 0.387 0.922 -0.002 -0.016 0.012 0.800 0.897 0.001 -0.010 0.011 0.909 0.972 -0.012 -0.039 0.015 0.388 0.604LPC(20:3) [sn2] -0.012 -0.033 0.010 0.299 0.903 -0.011 -0.024 0.003 0.124 0.385 -0.001 -0.011 0.010 0.921 0.975 -0.013 -0.040 0.014 0.345 0.564PE(18:0_22:5) (n6) -0.013 -0.034 0.009 0.258 0.903 -0.005 -0.019 0.009 0.488 0.705 -0.001 -0.011 0.010 0.922 0.975 0.001 -0.026 0.028 0.945 0.966TG(49:1) [NL-16:1] -0.019 -0.041 0.003 0.096 0.903 -0.006 -0.019 0.008 0.407 0.643 -0.001 -0.011 0.010 0.923 0.975 0.001 -0.026 0.028 0.950 0.968AC(14:0)-OH -0.006 -0.029 0.016 0.565 0.933 -0.006 -0.020 0.007 0.366 0.602 -0.001 -0.011 0.010 0.920 0.975 -0.019 -0.046 0.008 0.171 0.376PC(P-35:2) (a) -0.005 -0.027 0.017 0.657 0.960 -0.010 -0.024 0.004 0.168 0.433 0.001 -0.010 0.011 0.917 0.975 -0.007 -0.035 0.020 0.593 0.758AC(15:0) (b) -0.004 -0.026 0.018 0.714 0.964 -0.010 -0.023 0.004 0.163 0.432 0.001 -0.010 0.011 0.920 0.975 -0.032 -0.059 -0.005 0.019 0.0890.004 -0.018 0.026 0.733 0.964 0.006 -0.008 0.020 0.395 0.634 0.001 -0.010 0.011 0.917 0.975 -0.017 -0.043 0.010 0.229 0.439SM(d18:0/14:0) 0.002 -0.020 0.024 0.864 0.981 -0.004 -0.017 0.010 0.600 0.771 -0.001 -0.011 0.010 0.921 0.975 -0.030 -0.057 -0.002 0.035 0.132PE(18:0_22:4) -0.018 -0.039 0.004 0.114 0.903 -0.004 -0.018 0.010 0.590 0.764 0.001 -0.010 0.011 0.926 0.976 -0.002 -0.030 0.025 0.868 0.942PA(36:4) -0.002 -0.024 0.020 0.879 0.981 -0.003 -0.017 0.011 0.696 0.845 -0.001 -0.011 0.010 0.925 0.976 0.024 -0.004 0.051 0.091 0.241PC(39:5) (a) 0.009 -0.013 0.032 0.415 0.922 -0.009 -0.023 0.005 0.195 0.455 0.000 -0.010 0.011 0.928 0.976 -0.042 -0.070 -0.014 0.004 0.038Cer(d17:1/24:0) -0.005 -0.028 0.017 0.636 0.960 0.002 -0.012 0.017 0.735 0.870 0.000 -0.011 0.010 0.929 0.976 -0.003 -0.031 0.024 0.821 0.921PC(P-36:3) -0.007 -0.028 0.015 0.559 0.933 -0.005 -0.019 0.009 0.479 0.696 0.000 -0.011 0.010 0.933 0.979 -0.022 -0.049 0.005 0.111 0.277TG(50:2) [NL-16:1] -0.020 -0.041 0.002 0.079 0.903 -0.017 -0.030 -0.003 0.015 0.273 0.000 -0.011 0.010 0.939 0.980 -0.027 -0.055 0.001 0.056 0.173PE(18:0_20:3) (a) -0.013 -0.035 0.009 0.242 0.903 -0.012 -0.026 0.002 0.083 0.356 0.000 -0.011 0.010 0.938 0.980 -0.011 -0.038 0.016 0.438 0.644TG(50:3) [NL-18:3] -0.024 -0.045 -0.002 0.034 0.903 -0.010 -0.023 0.004 0.166 0.432 0.000 -0.010 0.011 0.936 0.980 0.002 -0.026 0.029 0.906 0.954PI(18:0_22:5) (n6) -0.009 -0.031 0.012 0.397 0.922 -0.019 -0.033 -0.005 0.007 0.259 0.000 -0.011 0.010 0.937 0.980 -0.006 -0.033 0.021 0.662 0.814PE(O-16:0/20:3) -0.017 -0.039 0.005 0.127 0.903 -0.005 -0.019 0.009 0.477 0.696 0.000 -0.011 0.010 0.941 0.980 -0.016 -0.042 0.011 0.249 0.464PE(17:0_18:1) -0.009 -0.031 0.013 0.441 0.922 -0.016 -0.030 -0.003 0.018 0.273 0.000 -0.010 0.011 0.944 0.982 -0.008 -0.036 0.019 0.556 0.734TG(50:2) [NL-18:1] -0.019 -0.041 0.003 0.084 0.903 -0.019 -0.033 -0.005 0.006 0.259 0.000 -0.011 0.010 0.952 0.984 -0.027 -0.055 0.002 0.065 0.186LPC(14:0) [sn1] -0.015 -0.037 0.008 0.203 0.903 -0.009 -0.023 0.005 0.205 0.466 0.000 -0.011 0.010 0.951 0.984 -0.013 -0.040 0.014 0.353 0.572PC(14:0_20:4) -0.013 -0.036 0.009 0.243 0.903 0.000 -0.014 0.014 0.985 0.989 0.000 -0.011 0.011 0.966 0.984 -0.011 -0.038 0.017 0.449 0.653PE(16:0_18:1) -0.014 -0.036 0.008 0.224 0.903 -0.012 -0.026 0.002 0.089 0.356 0.000 -0.011 0.011 0.965 0.984 -0.010 -0.038 0.017 0.466 0.664DG(16:0_18:1) -0.015 -0.037 0.007 0.170 0.903 -0.015 -0.029 -0.002 0.026 0.285 0.000 -0.010 0.011 0.963 0.984 -0.009 -0.037 0.019 0.519 0.709DG(18:0_18:2) -0.015 -0.037 0.007 0.180 0.903 -0.011 -0.024 0.003 0.116 0.384 0.000 -0.011 0.010 0.965 0.984 0.002 -0.025 0.030 0.862 0.937PA(36:1) 0.012 -0.010 0.034 0.276 0.903 -0.019 -0.033 -0.005 0.010 0.270 0.000 -0.011 0.011 0.963 0.984 -0.001 -0.031 0.029 0.941 0.966PC(15-MHDA_18:1) -0.011 -0.033 0.012 0.353 0.922 -0.019 -0.032 -0.005 0.009 0.268 0.000 -0.011 0.011 0.963 0.984 -0.039 -0.066 -0.011 0.006 0.048Cer(d20:1/24:0) -0.008 -0.030 0.014 0.498 0.922 -0.004 -0.018 0.010 0.563 0.748 0.000 -0.011 0.011 0.962 0.984 -0.012 -0.040 0.015 0.374 0.592methyl-CE(18:1) 0.009 -0.013 0.032 0.414 0.922 0.000 -0.014 0.014 0.970 0.983 0.000 -0.010 0.011 0.952 0.984 -0.012 -0.039 0.016 0.414 0.629Cer(d16:1/24:0) -0.007 -0.030 0.015 0.514 0.922 -0.005 -0.019 0.009 0.519 0.727 0.000 -0.011 0.011 0.954 0.984 0.001 -0.026 0.029 0.918 0.962PI(39:6) -0.007 -0.029 0.015 0.551 0.931 -0.015 -0.029 -0.002 0.030 0.289 0.000 -0.010 0.011 0.954 0.984 -0.014 -0.042 0.014 0.317 0.537-0.006 -0.028 0.016 0.596 0.950 -0.003 -0.017 0.011 0.707 0.849 0.000 -0.011 0.011 0.957 0.984 -0.027 -0.054 0.001 0.056 0.173AC(20:5) 0.004 -0.018 0.026 0.712 0.964 -0.009 -0.023 0.004 0.189 0.454 0.000 -0.011 0.011 0.967 0.984 -0.004 -0.031 0.023 0.762 0.891PC(15-MHDA_20:4) -0.003 -0.025 0.019 0.819 0.980 -0.007 -0.021 0.007 0.333 0.572 0.000 -0.011 0.010 0.950 0.984 -0.040 -0.067 -0.013 0.004 0.042PC(17:0_20:4) -0.001 -0.023 0.021 0.945 0.995 -0.004 -0.018 0.010 0.617 0.787 0.000 -0.010 0.011 0.961 0.984 -0.035 -0.063 -0.008 0.013 0.069PE(18:0_20:4) -0.011 -0.033 0.010 0.304 0.903 -0.008 -0.022 0.006 0.248 0.501 0.000 -0.011 0.011 0.977 0.990 -0.011 -0.039 0.017 0.435 0.641PC(18:2_20:5) 0.008 -0.014 0.031 0.470 0.922 -0.009 -0.023 0.005 0.201 0.463 0.000 -0.011 0.011 0.977 0.990 -0.001 -0.028 0.027 0.958 0.970LPI(18:2) [sn1] 0.000 -0.022 0.021 0.969 0.995 0.008 -0.006 0.022 0.263 0.514 0.000 -0.011 0.011 0.977 0.990 0.015 -0.012 0.042 0.286 0.509PE(18:0_20:3) (b) -0.018 -0.040 0.004 0.103 0.903 -0.020 -0.034 -0.007 0.004 0.259 0.000 -0.011 0.011 0.979 0.990 -0.019 -0.047 0.009 0.177 0.382PC(18:0_20:4) -0.002 -0.024 0.020 0.861 0.981 0.003 -0.011 0.017 0.687 0.840 0.000 -0.011 0.011 0.979 0.990 -0.023 -0.051 0.005 0.106 0.271PI(18:0_22:6) -0.009 -0.031 0.013 0.442 0.922 -0.016 -0.030 -0.002 0.026 0.285 0.000 -0.011 0.011 0.981 0.990 -0.018 -0.046 0.010 0.200 0.416DG(18:1_18:1) -0.008 -0.029 0.014 0.503 0.922 -0.018 -0.031 -0.004 0.011 0.273 0.000 -0.011 0.011 0.986 0.994 -0.018 -0.046 0.010 0.204 0.416PE(16:0_20:4) -0.013 -0.035 0.008 0.230 0.903 -0.011 -0.025 0.003 0.123 0.385 0.000 -0.011 0.011 0.995 0.998 -0.018 -0.046 0.010 0.205 0.416TG(50:2) [NL-18:2] -0.021 -0.043 0.000 0.051 0.903 -0.005 -0.019 0.009 0.489 0.706 0.000 -0.011 0.010 0.994 0.998 0.000 -0.027 0.028 0.980 0.985PC(P-20:0/20:4) -0.008 -0.030 0.014 0.492 0.922 -0.001 -0.014 0.013 0.920 0.953 0.000 -0.011 0.011 0.996 0.998 -0.031 -0.058 -0.004 0.024 0.105PE(P-16:0/22:5) (n6) -0.009 -0.031 0.013 0.423 0.922 0.003 -0.011 0.017 0.667 0.829 0.000 -0.011 0.011 0.998 0.998 0.000 -0.026 0.026 0.995 0.996Cer(d19:1/23:0) 0.004 -0.019 0.026 0.741 0.964 -0.008 -0.022 0.006 0.256 0.507 0.000 -0.011 0.011 0.996 0.998 -0.026 -0.053 0.001 0.063 0.184PE(P-16:0/18:3) -0.004 -0.026 0.018 0.718 0.964 0.001 -0.013 0.016 0.855 0.929 0.000 -0.011 0.011 0.997 0.998 0.008 -0.020 0.036 0.588 0.756PI(15-MHDA_20:4) & PI(17:0_20:4)SM(d18:1/22:0) & SM(d16:1/24:0)SM(d18:1/14:0) & SM(d16:1/16:0) ### Page 38 Supplementary Table 7. Associations of lipid classes with longitudinal A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid classes Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)GM3 -0.007 -0.029 0.015 0.543 0.901 -0.011 -0.026 0.003 0.116 0.382 -0.022 -0.032 -0.011 0.000 0.002 -0.065 -0.092 -0.038 0.000 0.000GM1 0.003 -0.020 0.025 0.823 0.901 -0.018 -0.032 -0.003 0.015 0.221 -0.015 -0.026 -0.005 0.005 0.063 -0.060 -0.089 -0.032 0.000 0.001deDE -0.001 -0.024 0.022 0.929 0.929 0.000 -0.014 0.015 0.952 0.973 -0.027 -0.038 -0.016 0.000 0.000 -0.057 -0.086 -0.029 0.000 0.001Hex3Cer -0.005 -0.027 0.017 0.681 0.901 -0.008 -0.022 0.006 0.261 0.512 -0.013 -0.024 -0.002 0.021 0.138 -0.050 -0.077 -0.023 0.000 0.004PC -0.011 -0.033 0.012 0.352 0.901 -0.013 -0.027 0.001 0.063 0.241 -0.006 -0.017 0.005 0.296 0.524 -0.045 -0.072 -0.018 0.001 0.011AC -0.003 -0.025 0.019 0.798 0.901 -0.014 -0.028 -0.001 0.041 0.224 -0.013 -0.023 -0.002 0.020 0.138 -0.044 -0.070 -0.017 0.002 0.012SM -0.003 -0.025 0.019 0.763 0.901 -0.006 -0.019 0.008 0.437 0.669 -0.004 -0.015 0.007 0.466 0.650 -0.042 -0.069 -0.016 0.002 0.013LPC(O) -0.010 -0.032 0.012 0.365 0.901 -0.020 -0.033 -0.006 0.006 0.221 -0.019 -0.029 -0.008 0.001 0.011 -0.041 -0.068 -0.013 0.004 0.019COH -0.005 -0.027 0.017 0.644 0.901 -0.003 -0.017 0.011 0.666 0.901 -0.005 -0.016 0.006 0.332 0.566 -0.040 -0.067 -0.013 0.004 0.019CE -0.002 -0.024 0.021 0.895 0.919 -0.002 -0.015 0.012 0.798 0.973 -0.008 -0.019 0.003 0.139 0.343 -0.039 -0.066 -0.012 0.005 0.025PC(O) -0.010 -0.032 0.012 0.360 0.901 -0.008 -0.022 0.006 0.274 0.512 -0.005 -0.015 0.006 0.408 0.608 -0.036 -0.062 -0.009 0.009 0.038PIP1 -0.006 -0.028 0.016 0.601 0.901 -0.007 -0.021 0.006 0.290 0.512 -0.008 -0.018 0.003 0.159 0.366 -0.035 -0.062 -0.008 0.011 0.040Cer(d) -0.011 -0.033 0.011 0.342 0.901 -0.011 -0.025 0.003 0.134 0.412 -0.007 -0.018 0.004 0.208 0.415 -0.034 -0.061 -0.006 0.016 0.058Hex2Cer -0.002 -0.024 0.020 0.877 0.919 -0.001 -0.015 0.013 0.881 0.973 -0.012 -0.023 -0.002 0.024 0.138 -0.032 -0.059 -0.005 0.022 0.068AC-OH -0.003 -0.025 0.019 0.802 0.901 -0.007 -0.021 0.006 0.300 0.512 -0.005 -0.015 0.006 0.409 0.608 -0.032 -0.060 -0.005 0.022 0.068HexCer 0.008 -0.014 0.030 0.467 0.901 -0.008 -0.022 0.005 0.230 0.495 -0.013 -0.024 -0.003 0.016 0.138 -0.031 -0.058 -0.003 0.028 0.079LPE -0.020 -0.042 0.002 0.078 0.901 -0.016 -0.029 -0.002 0.024 0.221 -0.012 -0.023 -0.001 0.030 0.153 -0.030 -0.058 -0.003 0.029 0.079PI -0.020 -0.042 0.002 0.077 0.901 -0.012 -0.026 0.002 0.099 0.351 -0.005 -0.016 0.006 0.354 0.582 -0.029 -0.056 -0.002 0.035 0.088LPC -0.007 -0.029 0.015 0.557 0.901 -0.014 -0.027 0.000 0.050 0.232 -0.011 -0.022 -0.001 0.041 0.170 -0.028 -0.055 0.000 0.048 0.114SHexCer -0.005 -0.027 0.018 0.679 0.901 -0.007 -0.021 0.007 0.346 0.562 -0.007 -0.018 0.004 0.200 0.415 -0.028 -0.056 0.000 0.050 0.114LPE(P) -0.004 -0.026 0.018 0.717 0.901 -0.007 -0.021 0.008 0.355 0.562 -0.008 -0.019 0.003 0.139 0.343 -0.026 -0.053 0.002 0.067 0.147C1P -0.004 -0.025 0.018 0.747 0.901 -0.001 -0.015 0.013 0.898 0.973 -0.010 -0.021 0.000 0.061 0.216 -0.025 -0.053 0.003 0.078 0.163LPC(P) -0.009 -0.031 0.013 0.424 0.901 -0.010 -0.024 0.004 0.162 0.467 -0.011 -0.022 0.000 0.048 0.182 -0.024 -0.051 0.003 0.087 0.174S1P -0.007 -0.029 0.015 0.514 0.901 -0.008 -0.022 0.006 0.237 0.495 -0.008 -0.019 0.003 0.142 0.343 -0.023 -0.050 0.004 0.098 0.187PC(P) -0.007 -0.029 0.015 0.534 0.901 -0.008 -0.022 0.006 0.280 0.512 0.001 -0.010 0.012 0.852 0.945 -0.020 -0.047 0.007 0.152 0.279DE 0.013 -0.009 0.035 0.240 0.901 0.009 -0.004 0.023 0.178 0.482 -0.009 -0.020 0.002 0.094 0.281 -0.020 -0.048 0.008 0.159 0.282TG(O) [NL] -0.012 -0.034 0.009 0.264 0.901 -0.004 -0.018 0.009 0.544 0.807 0.010 -0.001 0.020 0.079 0.260 0.017 -0.011 0.044 0.240 0.409OxSpecies -0.005 -0.027 0.018 0.692 0.901 -0.009 -0.023 0.005 0.203 0.491 -0.009 -0.020 0.002 0.098 0.281 -0.016 -0.044 0.012 0.250 0.411PE -0.016 -0.037 0.006 0.166 0.901 -0.015 -0.029 -0.001 0.032 0.224 -0.003 -0.014 0.008 0.582 0.765 -0.015 -0.043 0.012 0.282 0.448Sph 0.011 -0.011 0.033 0.317 0.901 -0.009 -0.022 0.005 0.229 0.495 0.001 -0.010 0.012 0.791 0.933 0.014 -0.013 0.041 0.308 0.472PE(P) -0.007 -0.029 0.015 0.528 0.901 0.000 -0.015 0.014 0.951 0.973 0.007 -0.004 0.018 0.201 0.415 -0.013 -0.041 0.014 0.329 0.474dimethyl-CE 0.013 -0.009 0.036 0.241 0.901 0.001 -0.013 0.015 0.923 0.973 0.000 -0.011 0.011 0.981 0.981 -0.014 -0.041 0.014 0.327 0.474methyl-CE 0.012 -0.010 0.035 0.279 0.901 0.003 -0.011 0.017 0.646 0.900 -0.002 -0.012 0.009 0.763 0.923 -0.012 -0.040 0.016 0.392 0.547Ubiquinone 0.007 -0.015 0.029 0.511 0.901 -0.004 -0.018 0.010 0.577 0.830 -0.004 -0.015 0.006 0.431 0.620 -0.010 -0.038 0.017 0.464 0.628TG [NL] -0.019 -0.041 0.002 0.083 0.901 -0.016 -0.029 -0.002 0.023 0.221 0.001 -0.010 0.011 0.896 0.958 -0.009 -0.037 0.019 0.539 0.708DG -0.015 -0.037 0.007 0.188 0.901 -0.013 -0.027 0.000 0.059 0.241 0.001 -0.009 0.012 0.829 0.945 -0.008 -0.035 0.020 0.592 0.757PE(O) -0.006 -0.029 0.016 0.571 0.901 0.002 -0.012 0.016 0.754 0.964 0.006 -0.004 0.017 0.237 0.454 -0.007 -0.034 0.020 0.625 0.777Cer(m) -0.018 -0.040 0.004 0.102 0.901 -0.009 -0.023 0.005 0.199 0.491 0.005 -0.006 0.015 0.401 0.608 -0.006 -0.034 0.021 0.646 0.782FFA -0.001 -0.024 0.021 0.899 0.919 0.000 -0.014 0.014 1.000 1.000 -0.002 -0.013 0.009 0.762 0.923 -0.006 -0.033 0.022 0.675 0.797dhCer -0.009 -0.032 0.013 0.403 0.901 0.002 -0.011 0.016 0.753 0.964 0.011 0.001 0.022 0.038 0.170 -0.003 -0.031 0.024 0.806 0.904BA -0.008 -0.031 0.014 0.461 0.901 0.002 -0.012 0.015 0.820 0.973 -0.004 -0.015 0.007 0.497 0.672 -0.003 -0.031 0.024 0.814 0.904PS 0.003 -0.019 0.025 0.796 0.901 -0.015 -0.028 -0.001 0.035 0.224 -0.003 -0.014 0.008 0.614 0.785 -0.003 -0.031 0.024 0.826 0.904PA -0.003 -0.025 0.019 0.809 0.901 -0.014 -0.028 0.000 0.044 0.224 -0.006 -0.017 0.005 0.258 0.474 0.002 -0.025 0.030 0.860 0.920LPI -0.003 -0.025 0.018 0.759 0.901 -0.001 -0.016 0.013 0.843 0.973 0.000 -0.011 0.010 0.943 0.981 0.002 -0.025 0.029 0.890 0.921methyl-DE 0.016 -0.006 0.039 0.151 0.901 0.001 -0.013 0.015 0.852 0.973 0.000 -0.011 0.011 0.965 0.981 0.002 -0.026 0.029 0.901 0.921PG -0.020 -0.042 0.002 0.080 0.901 -0.016 -0.029 -0.002 0.021 0.221 -0.001 -0.012 0.010 0.863 0.945 -0.001 -0.029 0.027 0.956 0.95695% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper)95% CI(Lower)95% CI(Upper) ### Page 39 Supplementary Table 8. Associations of lipid correlation network modules with longitudinal A/T/N biomarkersA: Amyloid PET (AV45) uptake T: CSF pTau N1: Hippocampal volume N2: FDG uptakeLipid modules Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH) Beta Pvalue Pvalue(BH)M23 -0.010 -0.032 0.012 0.378 0.900 -0.004 -0.018 0.009 0.536 0.782 -0.011 -0.022 0.000 0.041 0.147 -0.053 -0.079 -0.026 0.000 0.005M4 -0.007 -0.029 0.015 0.557 0.900 -0.015 -0.029 -0.001 0.030 0.270 -0.011 -0.021 0.000 0.055 0.168 -0.049 -0.076 -0.021 0.001 0.012M42 -0.009 -0.031 0.013 0.417 0.900 -0.011 -0.025 0.003 0.129 0.340 -0.011 -0.022 0.000 0.041 0.147 -0.045 -0.071 -0.018 0.001 0.014M44 -0.017 -0.039 0.004 0.119 0.900 -0.013 -0.027 0.001 0.061 0.309 -0.011 -0.022 0.000 0.048 0.159 -0.046 -0.073 -0.018 0.001 0.014M39 -0.010 -0.032 0.012 0.387 0.900 -0.021 -0.034 -0.007 0.004 0.164 -0.019 -0.030 -0.008 0.001 0.008 -0.042 -0.070 -0.015 0.002 0.014M26 -0.001 -0.024 0.021 0.894 0.935 -0.008 -0.022 0.005 0.233 0.465 -0.010 -0.020 0.001 0.074 0.213 -0.044 -0.071 -0.016 0.002 0.014M25 -0.006 -0.028 0.016 0.578 0.900 -0.016 -0.030 -0.002 0.024 0.270 -0.008 -0.019 0.003 0.150 0.346 -0.042 -0.069 -0.015 0.002 0.014M41 -0.009 -0.031 0.013 0.428 0.900 -0.010 -0.023 0.004 0.171 0.414 -0.002 -0.013 0.009 0.714 0.906 -0.043 -0.070 -0.015 0.002 0.014M18 0.005 -0.018 0.027 0.688 0.935 0.003 -0.010 0.017 0.627 0.849 -0.019 -0.030 -0.009 0.000 0.008 -0.037 -0.064 -0.009 0.009 0.040M38 -0.001 -0.024 0.021 0.901 0.935 -0.003 -0.017 0.011 0.696 0.873 -0.013 -0.024 -0.002 0.016 0.113 -0.036 -0.064 -0.009 0.010 0.040M28 0.003 -0.019 0.025 0.792 0.935 -0.008 -0.022 0.006 0.276 0.497 0.002 -0.009 0.012 0.760 0.906 -0.037 -0.064 -0.009 0.009 0.040M46 -0.005 -0.028 0.017 0.627 0.931 -0.013 -0.026 0.001 0.068 0.312 -0.001 -0.012 0.010 0.863 0.906 -0.035 -0.063 -0.008 0.011 0.041M11 -0.010 -0.032 0.012 0.380 0.900 -0.012 -0.025 0.002 0.091 0.340 -0.020 -0.031 -0.009 0.000 0.008 -0.032 -0.059 -0.006 0.018 0.060M14 -0.013 -0.035 0.009 0.243 0.900 -0.002 -0.016 0.012 0.804 0.902 -0.016 -0.026 -0.005 0.005 0.056 -0.032 -0.059 -0.006 0.018 0.060M6 -0.004 -0.026 0.018 0.723 0.935 -0.001 -0.015 0.013 0.863 0.922 -0.003 -0.014 0.008 0.581 0.835 -0.033 -0.061 -0.005 0.020 0.063M19 0.008 -0.014 0.030 0.467 0.900 -0.008 -0.022 0.005 0.230 0.465 -0.013 -0.024 -0.003 0.016 0.113 -0.031 -0.058 -0.003 0.028 0.075M35 -0.007 -0.029 0.015 0.531 0.900 -0.002 -0.016 0.012 0.761 0.898 -0.001 -0.012 0.010 0.867 0.906 -0.030 -0.057 -0.004 0.027 0.075M3 -0.008 -0.030 0.014 0.485 0.900 -0.015 -0.028 -0.001 0.038 0.270 -0.012 -0.023 -0.001 0.031 0.144 -0.030 -0.057 -0.003 0.030 0.077M31 -0.010 -0.032 0.011 0.351 0.900 -0.009 -0.023 0.004 0.188 0.433 -0.004 -0.015 0.007 0.456 0.724 -0.030 -0.057 -0.003 0.032 0.079M30 -0.020 -0.042 0.003 0.083 0.900 -0.011 -0.025 0.003 0.119 0.340 -0.002 -0.013 0.009 0.749 0.906 -0.027 -0.054 0.001 0.055 0.125M17 -0.002 -0.025 0.020 0.831 0.935 -0.008 -0.022 0.006 0.278 0.497 0.000 -0.010 0.011 0.936 0.936 -0.027 -0.054 0.001 0.057 0.125M21 -0.015 -0.037 0.006 0.163 0.900 -0.006 -0.020 0.008 0.412 0.654 -0.007 -0.018 0.004 0.192 0.420 -0.026 -0.053 0.001 0.060 0.126M45 0.001 -0.021 0.024 0.896 0.935 -0.011 -0.026 0.003 0.120 0.340 0.002 -0.009 0.013 0.743 0.906 -0.025 -0.053 0.003 0.077 0.154M13 -0.002 -0.024 0.021 0.876 0.935 0.003 -0.011 0.016 0.708 0.873 -0.005 -0.016 0.006 0.359 0.636 -0.023 -0.050 0.004 0.089 0.171M9 0.001 -0.021 0.023 0.914 0.935 0.003 -0.011 0.016 0.721 0.873 -0.001 -0.012 0.010 0.824 0.906 -0.022 -0.049 0.005 0.109 0.201M36 -0.007 -0.029 0.014 0.509 0.900 -0.011 -0.025 0.003 0.116 0.340 -0.009 -0.020 0.001 0.088 0.226 -0.020 -0.048 0.008 0.155 0.274M32 -0.009 -0.031 0.013 0.430 0.900 -0.008 -0.022 0.006 0.281 0.497 -0.006 -0.017 0.005 0.291 0.558 -0.020 -0.047 0.008 0.163 0.278M15 -0.008 -0.030 0.014 0.481 0.900 0.001 -0.013 0.015 0.857 0.922 0.003 -0.008 0.014 0.546 0.835 -0.017 -0.045 0.010 0.207 0.340M43 -0.013 -0.035 0.009 0.258 0.900 0.005 -0.008 0.019 0.448 0.688 -0.004 -0.015 0.007 0.442 0.724 -0.016 -0.043 0.010 0.227 0.359M16 -0.012 -0.034 0.009 0.264 0.900 -0.004 -0.018 0.009 0.544 0.782 0.010 -0.001 0.020 0.079 0.214 0.017 -0.011 0.044 0.240 0.368M40 -0.003 -0.025 0.019 0.789 0.935 -0.011 -0.025 0.003 0.113 0.340 -0.007 -0.018 0.004 0.213 0.446 -0.014 -0.042 0.013 0.300 0.435M1 -0.016 -0.038 0.006 0.143 0.900 -0.014 -0.028 0.000 0.045 0.270 -0.003 -0.014 0.008 0.572 0.835 -0.015 -0.042 0.013 0.302 0.435M22 -0.004 -0.026 0.018 0.711 0.935 -0.014 -0.028 -0.001 0.041 0.270 -0.001 -0.012 0.010 0.842 0.906 -0.014 -0.042 0.014 0.330 0.461M34 -0.014 -0.037 0.008 0.202 0.900 -0.010 -0.024 0.003 0.133 0.340 -0.011 -0.022 0.000 0.042 0.147 -0.013 -0.040 0.015 0.356 0.482M24 0.007 -0.016 0.029 0.563 0.900 -0.011 -0.025 0.003 0.125 0.340 0.005 -0.006 0.016 0.341 0.627 -0.010 -0.038 0.018 0.477 0.610M12 0.014 -0.008 0.037 0.212 0.900 0.002 -0.012 0.016 0.784 0.901 -0.001 -0.012 0.010 0.899 0.919 -0.010 -0.038 0.017 0.467 0.610M10 -0.012 -0.034 0.010 0.291 0.900 -0.006 -0.020 0.008 0.395 0.649 0.013 0.002 0.023 0.020 0.113 0.008 -0.019 0.035 0.544 0.676M27 -0.018 -0.040 0.004 0.102 0.900 -0.009 -0.023 0.005 0.199 0.436 0.005 -0.006 0.015 0.401 0.684 -0.006 -0.034 0.021 0.646 0.747M2 -0.021 -0.043 0.001 0.057 0.900 -0.015 -0.029 -0.002 0.026 0.270 0.001 -0.010 0.012 0.843 0.906 -0.007 -0.035 0.021 0.617 0.747M5 -0.002 -0.024 0.020 0.852 0.935 0.001 -0.013 0.015 0.894 0.922 -0.002 -0.013 0.009 0.711 0.906 -0.006 -0.034 0.021 0.649 0.747M7 0.012 -0.010 0.034 0.296 0.900 0.001 -0.013 0.015 0.902 0.922 -0.008 -0.019 0.003 0.133 0.323 -0.005 -0.032 0.023 0.748 0.839M33 0.001 -0.021 0.024 0.909 0.935 -0.014 -0.028 0.000 0.047 0.270 0.007 -0.004 0.018 0.229 0.458 0.003 -0.024 0.031 0.808 0.871M29 -0.017 -0.039 0.005 0.125 0.900 -0.007 -0.020 0.007 0.341 0.582 0.002 -0.009 0.012 0.755 0.906 -0.003 -0.031 0.025 0.831 0.871M20 -0.001 -0.023 0.021 0.946 0.946 -0.001 -0.015 0.013 0.937 0.937 -0.001 -0.012 0.010 0.864 0.906 0.003 -0.024 0.030 0.833 0.871M37 -0.003 -0.025 0.019 0.794 0.935 0.004 -0.010 0.017 0.610 0.849 0.013 0.002 0.024 0.018 0.113 -0.001 -0.028 0.026 0.929 0.949M8 -0.006 -0.028 0.016 0.587 0.900 0.003 -0.011 0.017 0.651 0.856 0.012 0.002 0.023 0.024 0.121 0.000 -0.028 0.027 0.984 0.98495% CI(Lower) 95% CI(Upper) 95% CI(Lower) 95% CI(Upper) 95% CI(Lower) 95% CI(Upper) 95% CI(Lower) 95% CI(Upper) ### Page 40 Supplementary Table 9. Cross-sectional and longitudinal associations between plasmalogen subtypes and AD biomarkersBaseline A/T/N biomarkers longitudinal A/T/N biomarkersA T N1 N2 A T N1 N2Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p-0.0810.04-0.1130.0010.0860.0010.0420.2380.0030.81-0.0070.3190.0090.117-0.0130.361(-0.158,-0.004) (-0.181,-0.045) (0.035,0.137) (-0.028,0.111) (-0.02,0.025) (-0.022,0.007) (-0.002,0.019) (-0.041,0.015)-0.0670.0710.010.7580.0580.02-0.0280.413-0.010.3680.0010.9010.0090.112-0.0040.799(-0.139,0.006) (-0.054,0.073) (0.009,0.108) (-0.094,0.038) (-0.032,0.012) (-0.013,0.015) (-0.002,0.019) (-0.031,0.024)Omega3 PlasmalogenOmega6 Plasmalogen ### Page 41 Supplementary Table 10. Indices-based analysis of plasma lipidomics profile in relation to AD biomarkersBaseline A/T/N biomarkers longitudinal A/T/N biomarkersA T N1 N2 A T N1 N2Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) p Beta(95%CI) pOmega3 index surrogate-0.0620.084-0.12<0.0010.0380.1160.0530.1130.0140.228-0.0040.6160.0080.1760.0010.934(-0.132,0.008) (-0.183,-0.057) (-0.009,0.085) (-0.013,0.118) (-0.008,0.036) (-0.017,0.01) (-0.003,0.018) (-0.027,0.029)CERT20.0340.3340.0080.814-0.0290.227-0.0930.005-0.0330.003-0.0170.018-0.0090.119-0.0310.029(-0.036,0.105) (-0.056,0.071) (-0.077,0.018) (-0.159,-0.028) (-0.055,-0.011) (-0.031,-0.003) (-0.019,0.002) (-0.059,-0.003) ### Page 42 Supplementary codelibrary(tidyverse)library(data.table)library(ADNIMERGE)library(Hmisc)library(lmerTest)library(broom.mixed)library(DT)library(future.apply)library(furrr)library(mergeutils)csf <- upennbiomk9 %>%mutate_if(is.character, list(~na_if(as.character(.),""))) %>% filter(!is.na(PTAU)) %>%mutate(VISCODE = as.character(VISCODE)) %>%mutate(PTAU = PTAU %>% as.numeric()) %>%mutate(PTAU_log=log10(PTAU)) %>%select(RID, VISCODE, PTAU_log)bmi <- read.csv("../data/BMI_IU.csv") %>%rowwise() %>%mutate(RID=str_split(RID_visit, pattern="_")[[1]][1] %>% as.integer(),VISCODE = str_split(RID_visit, pattern="_")[[1]][2]) %>%select(RID, VISCODE, BMI)lipid <- read.csv("../data/clinical_lipids.csv") %>%rowwise() %>%mutate(RID=str_split(RID_visit, pattern="_")[[1]][1] %>% as.integer(), VISCODE =str_split(RID_visit, pattern="_")[[1]][2]) %>%select(RID, VISCODE, hdl, chol, trig)fdg <- read.csv("../data/adni_fdg_IU.csv") %>% ### Page 43 select(RID, contains("Mean")) %>%pivot_longer(cols = -RID, names_to = "VISCODE0", values_to="FDG") %>%mutate(VISCODE = str_split(VISCODE0, pattern="_", simplify=T)[,1] %>% tolower(),region = str_split(VISCODE0, pattern="_", simplify=T)[,3]) %>%select(RID, VISCODE, region, FDG) %>% filter(!is.na(FDG)) %>%pivot_wider(names_from=region , values_from = FDG) %>%merge(., adnimerge %>% select(RID,VISCODE,FDG), by=c("RID","VISCODE"))mri <- read.csv("../data/adni_freesurfer_IU.csv") %>%pivot_longer(cols = -RID, names_to="VISCODE0", values_to="measurement") %>%filter(!is.na(measurement)) %>%mutate(VISCODE = str_split(VISCODE0, pattern="_", simplify=T)[,1] %>% tolower())%>%rowwise %>%mutate(region = paste(tail(str_split(VISCODE0, pattern="_")[[1]], -1), collapse="_") )%>%ungroup %>%filter(region %in% c("ICV", "Mag", "HippVol")) %>%pivot_wider(id_cols= c("RID","VISCODE"), names_from = "region", values_from ="measurement")av45 <- read.csv("../data/AV45_IU.csv") %>%select(RID, contains("FBP_WC_GlCtx"), -contains("CL")) %>%pivot_longer(names_to = "VISCODE", values_to = "AV45", values_drop_na = TRUE, cols= (-RID)) %>%mutate(VISCODE=tolower(str_remove(VISCODE, "_FBP_WC_GlCtx")), AV45 =log10(AV45))metadata <- adnimerge %>%select(RID, VISCODE, EXAMDATE, AGE, PTGENDER, PTEDUCAT ,APOE4) %>%mutate(APOE_bin = ifelse(APOE4==0,0,1)) %>%rename(age_bl = AGE) %>%filter(VISCODE=="bl") %>%select(-c(VISCODE, EXAMDATE)) ### Page 44 age_time <- adnimerge %>%select(RID, VISCODE, AGE, Years.bl) %>%mutate(age = AGE + Years.bl) %>%select(-AGE)# baseline phenotypesfdg_bl <- fdg %>% filter(VISCODE=='bl') %>% select(-VISCODE)mri_bl <- mri %>% filter(VISCODE=='bl') %>% select(-VISCODE)csf_bl <- csf %>% filter(VISCODE=="bl") %>% select(-VISCODE)av45_bl <- av45 %>% filter(VISCODE=="bl") %>% select(-VISCODE)# Lipid classes information (supplementary table 1)lipids <- read.csv("../data/lipid_species_revised.csv") %>%mutate(group = factor(group, levels = c("sphingolipids", "glycerophospholipids","Neutral/Other")),class=as.factor(class),abbr = as.factor(abbr),species = as.factor(species))pheno_df <- data.frame(rbind(data.frame(modality ="MRI", phenotype=”HippVol”),cbind(modality = "CSF", phenotype=”PTAU_log”),cbind(modality = "FDG", phenotype=”Temporal”),cbind(modality = "AV45", phenotype=”AV45”)))# Lipidomics DB callmlab <- fread("../data/MeikleLab_Lipidomics.csv") %>%select(1:10, all_of(lipids$species))mlab_log <- mlab %>%mutate(across("SPH.D18.1.":"PC.36.4....OH.", log10)) %>%as.data.tablemlab_log_duprm <- mlab_log %>%distinct(RID, VISCODE2, .keep_all=TRUE) %>% #duplicate removalselect(-VISCODE) %>% ### Page 45 rename(VISCODE = VISCODE2)# fasting datafasting <- read.csv("../data/Fasting.csv") %>%rowwise() %>%mutate(RID=str_split(RID_visit, pattern="_")[[1]][1] %>% as.integer(), VISCODE =str_split(RID_visit, pattern="_")[[1]][2]) %>%select(RID, VISCODE, fast)# lipidomics + fasting + clinical lipids datamlab_df <- merge(mlab_log_duprm, fasting, by=c("RID","VISCODE"), sort=F) %>%merge(lipid, by=c("RID","VISCODE"), all.x=T) %>%rename(BIFAST = fast)# fasting status data mergemlab_rids <- mlab_df$RID %>% unique######################################################## baseline species-level cross-sectional analysis #######################################################mlab_anal_cross <- mlab_df %>% filter(VISCODE=="bl") %>%merge(metadata, by="RID", all.x=T) %>%merge(age_time, by=c("RID","VISCODE"), all.x=T) %>%merge(fdg_bl, by="RID", all.x=TRUE) %>%merge(mri_bl, by="RID", all.x=TRUE) %>%merge(csf_bl, by="RID", all.x=TRUE) %>%merge(bmi, by=c("RID","VISCODE"), all.x=TRUE) %>%merge(av45_bl, by="RID", all.x=TRUE)mlab_metabolites <- lipids$species %>% as.charactermlab_grid_cross <- expand.grid(pheno_df$phenotype, mlab_metabolites) %>%set_names(c("phenotype","metabolite")) %>%merge(pheno_df, by="phenotype") %>%distinct_at(c("phenotype", "metabolite","modality")) %>% ### Page 46 rowwise() %>%mutate(formu_bl = ifelse(str_detect(modality,"MRI"), glue::glue("{phenotype} ~{metabolite} + age_bl + PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST +statin + omega3 + PTEDUCAT + ICV + Mag"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ {metabolite} +age_bl + PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3+ PTEDUCAT"),glue::glue("{phenotype} ~ {metabolite} + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3") )),formu_sex_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~ {metabolite}*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT + ICV + Mag"),ifelse(modality =="Cog", glue::glue("{phenotype} ~ {metabolite}*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT"),glue::glue("{phenotype} ~ {metabolite}*PTGENDER + age_bl +APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3"))),formu_apoe_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~ {metabolite}*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT + ICV + Mag"),ifelse(modality =="Cog", glue::glue("{phenotype} ~ {metabolite}*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT"),glue::glue("{phenotype} ~ {metabolite}*APOE_bin + age_bl +PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin + omega3")))) %>%ungroup()assoc_anal_cross <- function(modality, phenotype, metabolite, formu_bl, formu_sex_int,formu_apoe_int, df){model_bl <- lm(formula(formu_bl), data=df) %>% jtools::summ(scale=TRUE,transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.framepval <- model_bl[2,1:5] %>% set_names(c("b","CIlow","CIhigh","T_value","pval"))model_sex_int <- lm(formula(formu_sex_int), data=df) %>% jtools::summ(scale=TRUE,transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>%rownames_to_column("term")p_sex_int <- model_sex_int %>% filter(str_detect(term, ":PTGENDER")) %>% .[1,2:6]%>% set_names(c("b_sex_int","CIlow_sex_int","CIhigh_sex_int","T_sex_int","p_sex_int"))model_apoe_int <- lm(formula(formu_apoe_int), data=df) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% rownames_to_column("term")p_apoe_int <- model_apoe_int %>% filter(str_detect(term, ":APOE")) %>% .[1,2:6] %>%set_names(c("b_apoe_int","CIlow_apoe_int","CIhigh_apoe_int","T_apoe_int","p_apoe_int")) ### Page 47 }plan(multisession)mlab_result_cross <-future_pmap_dfr(mlab_grid_cross, ~assoc_anal_cross(..3,..1,..2,..4,..5, ..6,df=mlab_anal_cross), .progress=T) %>%group_by(phenotype) %>%mutate(p.fdr = p.adjust(pval, "BH"),p.male.fdr = p.adjust(p_male,"BH"),p.female.fdr=p.adjust(p_female,"BH")) %>%ungroup()######################################## baseline class-level analysis #########################################classes <- lipids$abbr %>% unique %>% as.character()mlab_cross_pca <- mlab_anal_cross %>% filter(VISCODE=="bl")for(i in seq_along(classes)){species_interest <- lipids %>% filter(abbr == classes[i]) %>% pull(species)mlab_sub <- mlab_cross_pca %>% select(all_of(species_interest))prc <- psych::principal(mlab_sub)tempdf <- prc$scores %>% data.frame %>% set_names(paste("class",classes[i],sep="_"))mlab_cross_pca <- cbind(mlab_cross_pca, tempdf)}classcols <- grep(names(mlab_cross_pca), pattern = "class", value = TRUE)phenocols <- pheno_df$phenotypemlab_grid_cross_pca <- expand.grid(phenocols, classcols) %>% ### Page 48 set_names("phenotype", "classes") %>%merge(pheno_df, by = "phenotype") %>%mutate(formu = ifelse(str_detect(modality,"MRI"), glue::glue("{phenotype} ~ `{classes}`+ age_bl + PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin +omega3 + PTEDUCAT + ICV + Mag"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}` + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3 +PTEDUCAT"),glue::glue("{phenotype} ~ `{classes}` + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3") )),formu.sex.int = ifelse(str_detect(modality,"MRI"), glue::glue("{phenotype} ~`{classes}`*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin+ omega3 + PTEDUCAT + ICV + Mag"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}`*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT"),glue::glue("{phenotype} ~ `{classes}`*PTGENDER + age_bl +APOE_bin + trig + hdl + chol + BMI + BIFAST+ statin + omega3") )),formu.apoe.int = ifelse(str_detect(modality,"MRI"), glue::glue("{phenotype} ~`{classes}`*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin+ omega3 + PTEDUCAT + ICV + Mag"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}`*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin + omega3+ PTEDUCAT"),glue::glue("{phenotype} ~ `{classes}`*APOE_bin + age_bl +PTGENDER + trig + hdl + chol + BMI + BIFAST+ statin + omega3") )))assoc_anal_cross_pca <- function(phenotype, classes, formu, formu.sex.int,formu.apoe.int, df){model_bl <- lm(formu, data=df)coeffs <- model_bl %>% jtools::summ(scale=TRUE, transform.response = TRUE,confint=TRUE) %>% .$coeftablepval <- coeffs[2,c(1,2,3,5)] %>% t() %>% data.frame %>%set_names(c("Beta","CIlow","CIhigh","pval"))model_sex_int <- lm(formu.sex.int, data=df)coeffs_sex_int <- model_sex_int %>% jtools::summ(scale=TRUE, transform.response =TRUE, confint=TRUE) %>% .$coeftable %>% as.data.framepval_sex_int <- coeffs_sex_int %>% select(1,2,3,5) %>% filter(.,grepl(":", rownames(.)))%>% `rownames<-`( NULL ) %>%set_names(c("Beta_sint","CIlow_sint","CIhigh_sint","pval_sint")) ### Page 49 model_apoe_int <- lm(formu.apoe.int, data=df)coeffs_apoe_int <- model_apoe_int %>% jtools::summ(scale=TRUE, transform.response= TRUE, confint=TRUE) %>% .$coeftable %>% as.data.framepval_apoe_int <- coeffs_apoe_int %>% select(1,2,3,5) %>% filter(.,grepl(":",rownames(.))) %>% `rownames<-`( NULL ) %>%set_names(c("Beta_aint","CIlow_aint","CIhigh_aint","pval_aint"))return(data.frame(phenotype, classes, pval, pval_sex_int, pval_apoe_int))}mlab_result_cross_pca <- future_pmap_dfr(mlab_grid_cross_pca,~assoc_anal_cross_pca(..1,..2,..4, ..5, ..6, df = mlab_cross_pca))######################################################## baseline metabolite - longitudinal phenotype association analysis ########################################################mlab_bl <- mlab_df %>%filter(VISCODE=="bl") %>%select(-c(VID, COHORT, SAMPLE.ID, VISCODE))mri_multi <- mri %>% group_by(RID) %>% filter(n()>=2) %>% ungroupcsf_multi <- csf %>% group_by(RID) %>% filter(n()>=2) %>% ungroupfdg_multi <- fdg %>% group_by(RID) %>% filter(n()>=2) %>% ungroupcog_multi <- cognition %>% group_by(RID) %>% filter(n()>=2) %>% ungroupav45_multi <- av45 %>% group_by(RID) %>% filter(n()>=2) %>% ungroupbmi_bl <- bmi %>% filter(VISCODE=="bl") %>% select(-VISCODE)pheno_long <- multimerge(list(csf_multi, mri_multi, fdg_multi, av45_multi, age_time),by=list(c("RID","VISCODE")))mlab_bl_met_long_phen <- multimerge(list(pheno_long, metadata, mlab_bl, bmi_bl),by="RID") %>%filter(complete.cases(Years.bl, PTGENDER, APOE4, BMI, trig, chol, hdl, PTEDUCAT,BIFAST)) ### Page 50 assoc_bl_met_long_phen <- function(modality, phenotype, metabolite, formu,formu_sex_int, formu_apoe_int, df){modelsummary <- lmer(formula(formu), data=df, na.action=na.exclude) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")pval <- modelsummary %>% filter(str_detect(term,":Years.bl")) %>% select(Est.,X2.5.,X97.5., p) %>% set_names(c("b", "CIlow","CIhigh","pval"))summary_sex_int <- lmer(formula(formu_sex_int), data=df, na.action=na.exclude) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")pval_sex_int <- summary_sex_int %>% filter(str_detect(term,":Years.bl:PTGENDER"))%>% select(Est., X2.5.,X97.5., p) %>%set_names(c("b_sex_int","CIlow_sex_int","CIhigh_sex_int","p_sex_int"))summary_apoe_int <- lmer(formula(formu_apoe_int), data=df, na.action=na.exclude)%>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")pval_apoe_int <- summary_apoe_int %>% filter(str_detect(term,":Years.bl:APOE_bin"))%>% select(Est., X2.5.,X97.5., p) %>%set_names(c("b_apoe_int","CIlow_apoe_int","CIhigh_apoe_int","p_apoe_int"))return(data.frame(modality, phenotype, metabolite, pval,pval_sex_int,pval_apoe_int))}grid_bl_met_long_phen <- expand.grid(c("HippVol", "PTAU_log", "Temporal", "AV45"),mlab_metabolites) %>%set_names(c("phenotype","metabolite")) %>%merge(pheno_df, by="phenotype") %>%distinct_at(c("phenotype", "metabolite","modality")) %>%rowwise() %>%mutate(formu = ifelse(modality == "MRI", glue::glue("{phenotype} ~ {metabolite}*Years.bl + age_bl + PTGENDER + APOE_bin + BMI + trig + chol + hdl + PTEDUCAT +scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),glue::glue("{phenotype} ~ {metabolite}*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl+ BIFAST + statin + omega3 + (Years.bl|RID)")), ### Page 51 formu_sex_int = ifelse(modality == "MRI", glue::glue("{phenotype} ~ {metabolite}*Years.bl*PTGENDER + age_bl + APOE_bin + BMI + trig + chol + hdl + PTEDUCAT +scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),glue::glue("{phenotype} ~ {metabolite}*Years.bl*PTGENDER +age_bl + APOE_bin + BMI + trig + chol + hdl+ BIFAST + statin + omega3 + (Years.bl|RID)")),formu_apoe_int = ifelse(modality == "MRI", glue::glue("{phenotype} ~{metabolite}*Years.bl*APOE_bin + age_bl + PTGENDER + BMI + trig + chol + hdl +PTEDUCAT + scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),glue::glue("{phenotype} ~ {metabolite}*Years.bl*APOE_bin + age_bl+ PTGENDER + BMI + trig + chol + hdl+ BIFAST + statin + omega3 + (Years.bl|RID)")))%>%ungroup()plan(multisession)pval_bl_met_long_phen <- future_pmap_dfr(grid_bl_met_long_phen,~assoc_bl_met_long_phen(..3,..1,..2,..4,..5,..6,df=mlab_bl_met_long_phen), .progress=T)mlab_result_bl_longi <- pval_bl_met_long_phen %>%group_by(phenotype) %>%mutate(p.fdr = p.adjust(pval, "BH")) %>%ungroup()############################################################################## longitudinal class level analysis (baseline lipid class PC1 – longitudinalphenotype)##############################################################################classcols <- grep(names(mlab_cross_pca), pattern = "class", value = TRUE)phenocols <- c("HippVol","PTAU_log","Temporal", "AV45")mlab_bl_longi_pca <-merge(mlab_bl_met_long_phen, mlab_cross_pca %>%select(RID,contains("class_")), by="RID", sort=F)mlab_grid_bl_longi_pca <- expand.grid(phenocols, classcols) %>%set_names("phenotype", "classes") %>% ### Page 52 merge(pheno_df, by = "phenotype") %>%mutate(formu = ifelse(modality == "MRI", glue::glue("{phenotype} ~ `{classes}`*Years.bl + age_bl + PTGENDER + APOE_bin + BMI + trig + chol + hdl + PTEDUCAT +scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}`*Years.bl +age_bl + PTGENDER + APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3+ PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ `{classes}`*Years.bl + age_bl +PTGENDER + APOE_bin + BMI + trig + chol + hdl+ BIFAST + statin + omega3 +(Years.bl|RID)"))),formu.sex = ifelse(modality == "MRI", glue::glue("{phenotype} ~ `{classes}`*Years.bl*PTGENDER + age_bl + APOE_bin + BMI + trig + chol + hdl + PTEDUCAT +scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}`*Years.bl*PTGENDER + age_bl + APOE_bin + BMI + trig + chol + hdl + BIFAST + statin+ omega3 + PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ `{classes}`*Years.bl*PTGENDER +age_bl + APOE_bin + BMI + trig + chol + hdl+ BIFAST + statin + omega3 + (Years.bl|RID)"))),formu.apoe = ifelse(modality == "MRI", glue::glue("{phenotype} ~ `{classes}`*Years.bl*APOE_bin + age_bl + PTGENDER + BMI + trig + chol + hdl + PTEDUCAT +scale(ICV) + factor(Mag) + BIFAST + statin + omega3 + (Years.bl|RID)"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ `{classes}`*Years.bl*APOE_bin + age_bl + PTGENDER + BMI + trig + chol + hdl + BIFAST + statin+ omega3 + PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ `{classes}`*Years.bl*APOE_bin + age_bl+ PTGENDER + BMI + trig + chol + hdl+ BIFAST + statin + omega3 + (Years.bl|RID)"))))assoc_anal_bl_longi_pca <- function(phenotype, classes, formu, formu.sex, formu.apoe, df){model_bl <- lmer(formu, data=df, na.action=na.exclude, control=lmerControl(optimizer= "Nelder_Mead"))coeffs <- model_bl %>% jtools::summ(scale=TRUE, transform.response = TRUE,confint=TRUE) %>% .$coeftable %>% data.framepval <- coeffs %>% select(1,2,3,6) %>% filter(.,grepl(":", rownames(.))) %>%set_names(c("Beta","CIlow","CIhigh","pval"))summary_sex_int <- lmer(formu.sex, data=df, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term") ### Page 53 pval_sex_int <- summary_sex_int %>% filter(str_detect(term,":Years.bl:PTGENDER"))%>% select(Est., X2.5.,X97.5., p) %>%set_names(c("b_sex_int","CIlow_sex_int","CIhigh_sex_int","p_sex_int"))summary_apoe_int <- lmer(formu.apoe, data=df, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")pval_apoe_int <- summary_apoe_int %>% filter(str_detect(term,":Years.bl:APOE_bin"))%>% select(Est., X2.5.,X97.5., p) %>%set_names(c("b_apoe_int","CIlow_apoe_int","CIhigh_apoe_int","p_apoe_int"))return(data.frame(phenotype, classes, pval,pval_sex_int, pval_apoe_int))}plan(multisession)mlab_result_bl_longi_pca <- future_pmap_dfr(mlab_grid_bl_longi_pca,~assoc_anal_bl_longi_pca(..1,..2,..4,..5,..6,df = mlab_bl_longi_pca))mlab_grid_bl_longi_species <- merge(grid_bl_met_long_phen %>% select(modality,metabolite, phenotype, formu),lipids %>% select(species, abbr), by.x = "metabolite", by.y="species", sort=FALSE) %>%mutate(abbr = factor(abbr, levels= classes))assoc_anal_bl_longi_pca_species <- function(species, phenotype, classes, formu, df){model_bl <- lmer(formu, data=df, na.action=na.exclude, control=lmerControl(optimizer= "Nelder_Mead"))coeffs <- model_bl %>% jtools::summ(scale=TRUE, transform.response = TRUE,confint=TRUE) %>% .$coeftable %>% data.framepval <- coeffs %>% select(1,2,3,6) %>% filter(.,grepl(":", rownames(.))) %>%set_names(c("Beta","CIlow","CIhigh","pval"))return(data.frame(phenotype,classes,species,pval))}########################################## WGCNA analysis ########################################### ### Page 54 library(WGCNA)#### data ####lipid_metabolites <- lipids$speciesdatLipid <- mlab_anal_cross %>% select(RID, all_of(lipid_metabolites)) %>%column_to_rownames("RID")#### power selection ####options(stringsAsFactors = FALSE)powers = c(c(1:10), seq(from = 12, to=20, by=2))sft = pickSoftThreshold(datLipid, powerVector = powers, verbose = 5)sizeGrWindow(9, 5)par(mfrow = c(1,2));cex1 = 0.9;# Scale-free topology fit index as a function of the soft-thresholding powerplot(sft$fitIndices[,1], -sign(sft$fitIndices[,3])*sft$fitIndices[,2],xlab="Soft Threshold (power)",ylab="Scale Free Topology Model Fit,signedR^2",type="n",main = paste("Scale independence"));text(sft$fitIndices[,1], -sign(sft$fitIndices[,3])*sft$fitIndices[,2],labels=powers,cex=cex1,col="red");# this line corresponds to using an R^2 cut-off of habline(h=0.80,col="red")# Mean connectivity as a function of the soft-thresholding powerplot(sft$fitIndices[,1], sft$fitIndices[,5],xlab="Soft Threshold (power)",ylab="Mean Connectivity", type="n",main = paste("Mean connectivity"))text(sft$fitIndices[,1], sft$fitIndices[,5], labels=powers, cex=cex1,col="red")#### module generation ####net = blockwiseModules(datLipid, power = 7,TOMType = "signed",corType = "bicor",minModuleSize = 5, ### Page 55 deepSplit =4,reassignThreshold = 0, mergeCutHeight = 0.25,numericLabels = FALSE, pamRespectsDendro = FALSE,verbose = 3)# removing grey module & converting to numbersmembership <- net$colors %>% as.data.frame() %>% set_names("Module") %>%filter(Module !="grey") %>% mutate(Module_num =paste0("M",as.numeric(as.factor(Module))))membership_convert <- membership %>% distinct################################################# Module -baseline phenotype analysis #################################################mlab_me_cross <- merge(mlab_anal_cross %>% data.frame, net$MEs, by.x="RID",by.y="row.names")phenos <- c("AV45", "PTAU_log" , "HippVol", "Temporal")menames <- names(net$MEs)[1:46]mlab_me_grid <- expand.grid(phenos, menames) %>%set_names(c("phenotype","ME_metabolite")) %>%merge(pheno_df, by="phenotype") %>%distinct_at(c("phenotype", "ME_metabolite","modality")) %>%rowwise() %>%mutate(formu_bl = ifelse(str_detect(modality,"MRI"), glue::glue("{phenotype} ~{ME_metabolite} + age_bl + PTGENDER + APOE_bin + BIFAST + BMI + hdl + chol + trig+ statin + omega3 + PTEDUCAT + ICV + factor(Mag)"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ {ME_metabolite} +age_bl + PTGENDER + APOE_bin + BIFAST + BMI + hdl + chol + trig + statin + omega3+ PTEDUCAT"), ### Page 56 glue::glue("{phenotype} ~ {ME_metabolite} + age_bl + PTGENDER+ APOE_bin + BIFAST + BMI + hdl + chol + trig + statin + omega3") )),formu_sex_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~{ME_metabolite}*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + statin + omega3+ BMI + BIFAST + PTEDUCAT + ICV + factor(Mag)"),ifelse(modality =="Cog", glue::glue("{phenotype} ~ {ME_metabolite}*PTGENDER + age_bl + APOE_bin + trig + hdl + chol + statin + omega3 + BMI + BIFAST+ PTEDUCAT"),glue::glue("{phenotype} ~ {ME_metabolite}*PTGENDER +age_bl + APOE_bin + trig + hdl + chol + statin + omega3 + BMI + BIFAST"))),formu_apoe_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~{ME_metabolite}*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + statin + omega3+ BMI + BIFAST + PTEDUCAT + ICV + factor(Mag)"),ifelse(modality =="Cog", glue::glue("{phenotype} ~{ME_metabolite}*APOE_bin + age_bl + PTGENDER + trig + hdl + chol + statin + omega3+ BMI + BIFAST + PTEDUCAT"),glue::glue("{phenotype} ~ {ME_metabolite}*APOE_bin + age_bl+ PTGENDER + trig + hdl + chol + statin + omega3 + BMI + BIFAST")))) %>%ungroup()assoc_me_cross <- function(modality, phenotype, me_metabolite, formu_bl, formu_sex_int,formu_apoe_int, df){model_bl <- lm(formula(formu_bl), data=df) %>% jtools::summ(scale=TRUE,transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.framepval <- model_bl[2,1:5] %>% set_names(c("b","CIlow","CIhigh","T_value","pval"))model_sex_int <- lm(formula(formu_sex_int), data=df) %>% jtools::summ(scale=TRUE,transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>%rownames_to_column("term")p_sex_int <- model_sex_int %>% filter(str_detect(term, ":PTGENDER")) %>% .[1,2:6]%>% set_names(c("b_sex_int","CIlow_sex_int","CIhigh_sex_int","T_sex_int","p_sex_int"))model_apoe_int <- lm(formula(formu_apoe_int), data=df) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame%>% rownames_to_column("term")p_apoe_int <- model_apoe_int %>% filter(str_detect(term, ":APOE")) %>% .[1,2:6] %>%set_names(c("b_apoe_int","CIlow_apoe_int","CIhigh_apoe_int", "T_apoe_int","p_apoe_int"))return(data.frame(modality, phenotype, me_metabolite, pval, p_sex_int, p_apoe_int))}plan(multisession)mlab_me_result_cross <- ### Page 57 future_pmap_dfr(mlab_me_grid, ~assoc_me_cross(..3,..1,..2,..4,..5,..6,df=mlab_me_cross),.progress=T) %>%group_by(phenotype) %>%mutate(p.fdr = p.adjust(pval, "BH"),p.sex.int.fdr = p.adjust(p_sex_int, "BH"),p.e4.int.fdr = p.adjust(p_apoe_int, "BH")) %>%ungroup()me_result_df <- mlab_me_result_cross %>% filter(p.fdr < 0.05) %>% rowwise() %>%mutate(n_metabolites = sum(paste("ME",net$colors,sep="") == me_metabolite)) %>%ungroup %>%mutate(Module = str_remove(me_metabolite, "ME")) %>% arrange(phenotype,p.fdr)%>%mutate(p.sexint.fdr = p.adjust(p_sex_int,"BH"),p.apoeint.fdr = p.adjust(p_apoe_int,"BH")) %>%mutate_if(is.numeric, ~signif(.x,2)) %>%ungroup %>%select(phenotype, Module, n_metabolites, T_value, p.fdr,p.sexint.fdr,p.apoeint.fdr)datatable(me_result_df)############################################# module - longitudinal phenotype ###############################################mlab_bl_ME_long_phen <- merge(mlab_bl_met_long_phen, net$MEs, by.x="RID",by.y="row.names")assoc_bl_ME_long_phen <- function(modality, phenotype, module,formu, formu_sex_int,formu_apoe_int, df){modelsummary <- lmer(formula(formu), data=df, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term") ### Page 58 pval <- modelsummary %>% filter(str_detect(term,":Years.bl")) %>% select(Est.,X2.5.,X97.5., t.val., p) %>% set_names(c("estimate", "CIlow","CIhigh","T_value", "pval"))model_sex_int <- lmer(formula(formu_sex_int), data=df, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")p_sex_int <- model_sex_int %>% filter(str_count(term, ":")==2) %>% select(Est.,X2.5.,X97.5., p) %>%set_names(c("b_sex_int","CIlow_sex_int","CIhigh_sex_int","p_sex_int"))model_apoe_int <- lmer(formula(formu_apoe_int), data=df, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% data.frame %>% rownames_to_column("term")p_apoe_int <- model_apoe_int %>% filter(str_count(term, ":")==2) %>% select(Est.,X2.5.,X97.5., p) %>%set_names(c("b_apoe_int","CIlow_apoe_int","CIhigh_apoe_int","p_apoe_int"))return(data.frame(modality, phenotype, module, pval,p_sex_int,p_apoe_int))}grid_bl_ME_long_phen <- expand.grid(phenos, menames) %>%set_names(c("phenotype","module")) %>%merge(pheno_df, by="phenotype") %>%distinct_at(c("phenotype", "module","modality")) %>%rowwise() %>%mutate(formu = ifelse(modality == "MRI", glue::glue("{phenotype} ~ {module}*Years.bl+ age_bl + PTGENDER + APOE_bin + BMI + trig + chol + statin + omega3 + hdl +PTEDUCAT + scale(ICV) + factor(Mag) + BIFAST + (Years.bl|RID)"),ifelse(modality=="Cog", glue::glue("{phenotype} ~ {module}*Years.bl +age_bl + PTGENDER + APOE_bin + BMI + trig + chol + statin + omega3 + hdl + BIFAST+ PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ {module}*Years.bl + age_bl + PTGENDER+ APOE_bin + BMI + trig + chol + statin + omega3 + hdl+ BIFAST + (Years.bl|RID)"))),formu_sex_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~ {module}*PTGENDER*Years.bl + age_bl + APOE_bin + trig + hdl + chol + statin + omega3 + BMI+ BIFAST + PTEDUCAT + scale(ICV) + factor(Mag) + (Years.bl|RID)"), ### Page 59 ifelse(modality =="Cog", glue::glue("{phenotype} ~ {module}*PTGENDER*Years.bl + age_bl + APOE_bin + trig + hdl + chol + statin + omega3 + BMI+ BIFAST + PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ {module}*PTGENDER*Years.bl +age_bl + APOE_bin + trig + hdl + chol + statin + omega3 + BMI + BIFAST + (Years.bl|RID)"))),formu_apoe_int = ifelse(modality =="MRI", glue::glue("{phenotype} ~ {module}*APOE_bin*Years.bl + age_bl + PTGENDER + trig + hdl + chol + statin + omega3 + BMI+ BIFAST + PTEDUCAT + scale(ICV) + factor(Mag) + (Years.bl|RID)"),ifelse(modality =="Cog", glue::glue("{phenotype} ~ {module}*APOE_bin*Years.bl + age_bl + PTGENDER + trig + hdl + chol + statin + omega3 + BMI+ BIFAST + PTEDUCAT + (Years.bl|RID)"),glue::glue("{phenotype} ~ {module}*APOE_bin*Years.bl +age_bl + PTGENDER + trig + hdl + chol + statin + omega3 + BMI + BIFAST + (Years.bl|RID)")))) %>%ungroup()plan(multisession)pval_bl_ME_long_phen <- future_pmap_dfr(grid_bl_ME_long_phen,~assoc_bl_ME_long_phen(..3,..1,..2,..4,..5,..6,df=mlab_bl_ME_long_phen), .progress=T)mlab_result_bl_ME_longi <- pval_bl_ME_long_phen %>%group_by(phenotype) %>%mutate(p.fdr = p.adjust(pval, "BH"),) %>%ungroup()############################################ Plasmalogen – omega3, omega6 analysis ############################################# cross-sectionalomega3 <- lipids %>% filter(plasmalogen_omega == "omega3") %>% pull(species)omega6 <- lipids %>% filter(plasmalogen_omega == "omega6") %>% pull(species)omega3prc <- mlab_cross_pca %>% select(all_of(omega3)) %>% psych::principal()omega6prc <- mlab_cross_pca %>% select(all_of(omega6)) %>% psych::principal() ### Page 60 omegapca <- cbind(omega3prc$scores %>% data.frame %>% set_names("omega3pc"),omega6prc$scores %>% data.frame %>% set_names("omega6pc"))mlab_cross_pca_omega <- cbind(mlab_cross_pca, omegapca)o3_A <- lm(mlab_cross_pca_omega, formula = AV45 ~ omega3pc + age_bl + PTGENDER+ APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o6_A <- lm(mlab_cross_pca_omega, formula = AV45 ~ omega6pc + age_bl + PTGENDER+ APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3_T<-lm(mlab_cross_pca_omega, formula = PTAU_log ~ omega3pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o6_T <-lm(mlab_cross_pca_omega, formula = PTAU_log ~ omega6pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3_N1<-lm(mlab_cross_pca_omega, formula = HippVol ~ omega3pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3 +PTEDUCAT + ICV + Mag) %>% jtools::summ(scale=TRUE, transform.response = TRUE,confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o6_N1 <-lm(mlab_cross_pca_omega, formula = HippVol ~ omega6pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3 +PTEDUCAT + ICV + Mag) %>% jtools::summ(scale=TRUE, transform.response = TRUE,confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3_N2<-lm(mlab_cross_pca_omega, formula = Temporal ~ omega3pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o6_N2<-lm(mlab_cross_pca_omega, formula = Temporal ~ omega6pc + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]omegatable <- function(df){df%>% round(3) %>% mutate(`Beta(95%CI)` = paste0(Est.,"(",X2.5.,",",X97.5.,")"))%>% select(6,5) ### Page 61 }omegaresults <- rbind(cbind(o3_A %>% omegatable, o3_T %>% omegatable,o3_N1 %>% omegatable, o3_N2%>% omegatable),cbind(o6_A %>% omegatable, o6_T %>% omegatable,o6_N1 %>% omegatable, o6_N2%>% omegatable)) %>% `row.names<-`(c("Omega3 Plasmalogen","Omega6 Plasmalogen"))# longitudinalmlab_longi_pca_omega <- merge(mlab_bl_longi_pca, mlab_cross_pca_omega %>%select(RID, omega3pc, omega6pc), by="RID")o3_AL <- lmer(formula = AV45~ omega3pc*Years.bl + age_bl + PTGENDER + APOE_bin+ BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())o3_TL <- lmer(formula = PTAU_log~ omega3pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o3_N1L <-lmer(formula = HippVol~ omega3pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + scale(ICV) +factor(Mag) + PTEDUCAT + (Years.bl|RID), data=mlab_longi_pca_omega,na.action=na.exclude, control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o3_N2L <- lmer(formula = Temporal~ omega3pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o6_AL <- lmer(formula = AV45~ omega6pc*Years.bl + age_bl + PTGENDER + APOE_bin+ BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID), ### Page 62 data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o6_TL <-lmer(formula = PTAU_log~ omega6pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o6_N1L <- lmer(formula = HippVol~ omega6pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + scale(ICV) +factor(Mag) + PTEDUCAT + (Years.bl|RID), data=mlab_longi_pca_omega,na.action=na.exclude, control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o6_N2L <- lmer(formula = Temporal~ omega6pc*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())omegatable_longi <- function(df){df%>% round(3) %>% mutate(`Beta(95%CI)` = paste0(Est.,"(",`2.5%`,",",`97.5%`,")"))%>% select(7,6)}omegaresults_long <- rbind(cbind(o3_AL %>% omegatable_longi, o3_TL %>% omegatable_longi,o3_N1L %>%omegatable_longi, o3_N2L %>% omegatable_longi),cbind(o6_AL %>% omegatable_longi, o6_TL %>% omegatable_longi,o6_N1L %>%omegatable_longi, o6_N2L %>% omegatable_longi)) %>% `row.names<-`(c("Omega3 Plasmalogen","Omega6 Plasmalogen"))################################ Omega 3 index analysis ################################ ### Page 63 species_names <- lipids %>% filter(group=="glycerophospholipids") %>% pull(species)omega3_species <- species_names[grepl("20.5|22.6", species_names) | (grepl("22.5",species_names) & !grepl("N6", species_names))]###### O3 index - percent omega3 method - divided by total phospholipids ####### cross-sectionalmlab_cross_pca_omega <- mlab_cross_pca %>%rowwise() %>%mutate(PL_total = sum(c_across(all_of(species_names))),omega3_total = sum(c_across(all_of(omega3_species))),omega3_index = (omega3_total / PL_total) * 100) %>%ungroup()o3i_A <- lm(mlab_cross_pca_omega, formula = AV45 ~ omega3_index + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3i_T<-lm(mlab_cross_pca_omega, formula = PTAU_log ~ omega3_index + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3i_N1<-lm(mlab_cross_pca_omega, formula = HippVol ~ omega3_index + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3 + ICV +Mag) %>% jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]o3i_N2<-lm(mlab_cross_pca_omega, formula = Temporal ~ omega3_index + age_bl +PTGENDER + APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]# longitudinalmlab_longi_pca_omega_index <- merge(mlab_bl_longi_pca, mlab_cross_pca_omega %>%select(RID, omega3_index), by="RID")o3i_AL <- lmer(formula = AV45~ omega3_index*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID), ### Page 64 data=mlab_longi_pca_omega_index, na.action=na.exclude, control=lmerControl(optimizer= "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())o3i_TL <- lmer(formula = PTAU_log~ omega3_index*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega_index, na.action=na.exclude, control=lmerControl(optimizer= "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o3i_N1L <-lmer(formula = HippVol~ omega3_index*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + scale(ICV) +factor(Mag) + PTEDUCAT + (Years.bl|RID), data=mlab_longi_pca_omega_index,na.action=na.exclude, control=lmerControl(optimizer = "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())o3i_N2L <- lmer(formula = Temporal~ omega3_index*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_omega_index, na.action=na.exclude, control=lmerControl(optimizer= "Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable %>% as.data.frame %>% slice(n())############################## ceramide index - cert2 #############################mlab_cross_pca_cer <- mlab_cross_pca %>%mutate(cer_ratio1 = CER.D18.1.24.1./CER.D18.1.24.0.,cer_ratio2 = CER.D18.1.16.0./PC.38.5...A.,cer_ratio3 = CER.D18.1.18.0./PC.14.0_22.6.) %>%mutate(cer_quart1 = ntile(cer_ratio1,4)-1,cer_quart2 = ntile(cer_ratio2,4)-1,cer_quart3 = ntile(cer_ratio3,4)-1,pc_quart1 = ntile(PC.16.0_16.0.,4)-1) %>%mutate(cert2 =cer_quart1 + cer_quart2 + cer_quart3 +pc_quart1) ### Page 65 cert2_A <- lm(mlab_cross_pca_cer, formula = AV45 ~ cert2 + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]cert2_T <- lm(mlab_cross_pca_cer, formula = PTAU_log ~ cert2 + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]cert2_N1 <- lm(mlab_cross_pca_cer, formula = HippVol ~ cert2 + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3 + ICV + Mag) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]cert2_N2 <- lm(mlab_cross_pca_cer, formula = Temporal ~ cert2 + age_bl + PTGENDER +APOE_bin + trig + hdl + chol + BMI + BIFAST + statin + omega3) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% data.frame %>% .[2,]ceramide_results <- cbind(cert2_A %>% omegatable, cert2_T %>% omegatable,cert2_N1%>% omegatable, cert2_N2 %>% omegatable)knitr::kable(ceramide_results) %>% kableExtra::kable_styling() %>%kableExtra::add_header_above(c(" "=1, "A" = 2, "T" = 2,"N1"=2, "N2"=2))mlab_longi_pca_cer <- merge(mlab_bl_longi_pca,mlab_cross_pca_cer %>% select(RID,cert2), by="RID" )cert2_AL <- lmer(formula = AV45~ cert2*Years.bl + age_bl + PTGENDER + APOE_bin +BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_cer, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())cert2_TL <- lmer(formula = PTAU_log~ cert2*Years.bl + age_bl + PTGENDER + APOE_bin+ BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_cer, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())cert2_N1L <-lmer(formula = HippVol~ cert2*Years.bl + age_bl + PTGENDER + APOE_bin+ BMI + trig + chol + hdl + BIFAST + statin + omega3 + scale(ICV) + factor(Mag) +PTEDUCAT + (Years.bl|RID), data=mlab_longi_pca_cer, na.action=na.exclude,control=lmerControl(optimizer = "Nelder_Mead")) %>% ### Page 66 jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())cert2_N2L <- lmer(formula = Temporal~ cert2*Years.bl + age_bl + PTGENDER +APOE_bin + BMI + trig + chol + hdl + BIFAST + statin + omega3 + (Years.bl|RID),data=mlab_longi_pca_cer, na.action=na.exclude, control=lmerControl(optimizer ="Nelder_Mead")) %>%jtools::summ(scale=TRUE, transform.response = TRUE, confint=TRUE) %>% .$coeftable%>% as.data.frame %>% slice(n())ceramide_results_longi <- cbind(cert2_AL %>% omegatable_longi, cert2_TL %>%omegatable_longi,cert2_N1L %>% omegatable_longi, cert2_N2L %>% omegatable_longi)knitr::kable(ceramide_results_longi) %>% kableExtra::kable_styling() %>%kableExtra::add_header_above(c(" "=1, "A" = 2, "T" = 2,"N1"=2, "N2"=2))