# paper.pdf ## Metadata - PDFFormatVersion=1.7 - Language=zh - IsLinearized=false - IsAcroFormPresent=false - IsXFAPresent=false - IsCollectionPresent=false - IsSignaturesPresent=false - Author=yanggy@connect.hku.hk - Creator=Microsoft® Word 适用于 Microsoft 365 - CreationDate=D:20260507221327-04'00' - ModDate=D:20260507221327-04'00' - Producer=Microsoft® Word 适用于 Microsoft 365 - pdf:producer=Microsoft® Word 适用于 Microsoft 365 - dc:creator=yanggy@connect.hku.hk - xmp:creatortool=Microsoft® Word 适用于 Microsoft 365 - xmp:createdate=2026-05-07T22:13:27-04:00 - xmp:modifydate=2026-05-07T22:13:27-04:00 - xmpmm:documentid=uuid:4F87C901-F93F-4032-B4C2-C34EE51480E9 - xmpmm:instanceid=uuid:4F87C901-F93F-4032-B4C2-C34EE51480E9 ## Contents ### Page 1 Online-Only Supplements eTable 1. A summary of genome-wide association studies used in this study. eFigure 1. Regional plots for genetic instruments for GLP-1R activation. eTable 2. SNP-specific estimates for genetic instruments for GLP-1R activation on BMI(kg/m2) and HbA1c (mmol/mol). eFigure 2. The associations of genetic instruments for GLP-1R activation with GLP1Rexpression in the ten most highly expressed tissues. eTable 3. SNP-specific estimates for genetic instruments for GLP-1R activation on plasmaGLP-1R levels. eTable 4. MR estimates for the associations of GLP-1R activation with HbA1c (mmol/mol)and BMI (kg/m2). eTable 5. SNP-specific estimates for genetic instruments for BMI (kg/m2) and HbA1c(mmol/mol). eFigure 3. IVW MR estimates for the associations of GLP-1R activation with the risk ofcoronary artery disease and all-cause mortality in comparison with those for lower BMI andlower HbA1c. eTable 6. MR sensitivity analyses for the associations of lower BMI and lower HbA1c withthe risk of coronary artery disease and all-cause mortality. eFigure 4. IVW MR estimates for sex-specific associations of GLP-1R activation with therisk of depressive symptoms in comparison with those for lower BMI and lower HbA1c. eTable 7. MR sensitivity analyses for the associations of lower BMI and lower HbA1c withmental health well-being. eFigure 5. IVW MR estimates for sex-specific associations of GLP-1R activation with therisk of major depressive disorder, schizophrenia, and ADHD in comparison with those forlower BMI and lower HbA1c. eTable 8. MR sensitivity analyses for the associations of lower BMI and lower HbA1c withthe risk of mental health disorders. eTable 9. MR sensitivity analyses for the associations of lower BMI and lower HbA1c withthe risk of substance use disorders. ### Page 2 eFigure 6. IVW MR estimates for the associations of GLP-1R activation with mental healthoutcomes in comparison with those for lower BMI and lower HbA1c in FinnGen. eTable 10. MR sensitivity analyses for the associations of lower BMI and lower HbA1c withmental health outcomes in FinnGen. eTable 11. Wald estimates for the associations of lower HbA1c via GLP-1R activation(instrumented by rs10305492) with coronary artery disease, all-cause mortality, and mentalhealth outcomes. eTable 12. The posterior probabilities of different hypotheses in pairwise colocalizationanalyses for BMI and each significant outcome within 1 Mb of the GLP1R gene. ### Page 3 eTable 1. A summary of genome-wide association studies used in this study. Category Phenotype Study Ancestry Sex N (case/control) Covariates PMID Geneticinstruments Body mass index UKB, GIANT European Overall 806,834 Sex, age at assessment, age at assessment2,and assessment center (UKB); sex, age, age2,and study-specific covariates (GIANT) 30239722 Body mass index UKB, GIANT European Women 434,794 Age at assessment, age at assessment2, andassessment center (UKB); age, age2, andstudy-specific covariates (GIANT) 30239722 Body mass index UKB, GIANT European Men 374,756 Age at assessment, age at assessment2, andassessment center (UKB); age, age2, andstudy-specific covariates (GIANT) 30239722 HbA1c UKB European Overall 344,182 Age, age2, inferred sex, age ×inferred sex,age2 × inferred sex, and the first 20 PCs Neale lab HbA1c UKB European Women 185,022 Age, age2, and the first 20 PCs Neale lab HbA1c UKB European Men 159,160 Age, age2, and the first 20 PCs Neale lab Tissue-specific GLP1Rexpression GTEx v10 Mixed(European ~85%) Overall 943 The first five PCs, PEER factors, PCR,platform, and sex 32913098 Plasma GLP-1R level UKB-PPP European Overall 32,867 Age, age2, sex, age × sex, age2 × sex, batch,centre, genetic array, time between bloodsampling and measurement, and the first 10PCs 37794186 Cardiovascularand mortalityoutcome Coronary artery disease UKB,CARDIoGRAMplusC4D Mixed(European >95%) Overall 181,522/984,168 Study-specific covariates 36474045 Parental mortality UKB, LifeGen European Overall 609,139/403,101 Genotyping batch and array, the first 40 PCsof relatedness, and participant sex (UKB);participant sex, the first 10 PCs, and study-specific covariates (LifeGen) 30642433 ### Page 4 Primaryoutcome Well-being spectrum Meta-analysis European Overall 2,370,390 Study-specific covariates 30643256 Major depressive disorder PGCexcluding23andMe European Overall 412,305/1,588,397 The first four PCs and any other PC that wasnominally significantly associated with thephenotype 39814019 Major depressive disorder Meta-analysis European Women 130,471/159,521 The first ten PCs, a genetic relationshipmatrix, and study-specific covariates 40858613 Major depressive disorder Meta-analysis European Men 64,805/132,185 The first ten PCs, a genetic relationshipmatrix, and study-specific covariates 40858613 Bipolar disorder Meta-analysis European Overall 41,917/371,549 The first five PCs and any others as required 34002096 PTSD PGC, UKB European Overall 23,212/151,447 The first five PCs (unrelated subjects); thefirst five PCs and a genetic relatedness matrix(family and twin studies); the first six PCs,batch, and center indicator variables (UKB) 31594949 Schizophrenia PGC European Overall 53,386/77,258 The first four PCs and any other PC that wasnominally significantly associated with thephenotype 35396580 Schizophrenia PGC European Women 17,710/36,803 The first four PCs and any other PC that wasnominally significantly associated with thephenotype 35396580 Schizophrenia PGC European Men 33,097/35,190 The first four PCs and any other PC that wasnominally significantly associated with thephenotype 35396580 Anorexia nervosa PGC, UKB European Overall 16,992/55,525 The first five PCs and any other PC that wasnominally associated with the phenotype 31308545 Attention deficithyperactivity disorder iPSYCH,deCODE,PGC European Overall 38,691/186,843 The first ten PCs (iPSYCH); sex, year ofbirth, county of origin, populationstratification, and relatedness (deCODE); PCsand study-specific covariates (PGC) 36702997 ### Page 5 Attention deficithyperactivity disorder iPSYCH, PGC European Women 4,945/16,246 The first four PCs and any other PC that wasnominally significantly associated with thephenotype (iPSYCH); the first five or ten PCsor indicator variables coding for site ID(PGC) 29325848 Attention deficithyperactivity disorder iPSYCH, PGC European Men 14,154/17,948 The first four PCs and any other PC that wasnominally significantly associated with thephenotype (iPSYCH); the first five or ten PCsor indicator variables coding for site ID(PGC) 29325848 Autism spectrum disorder iPSYCH, PGC European Overall 18,381/27,969 The first four PCs and any other PC that wasnominally significantly associated with thephenotype (iPSYCH); study-specificcovariates (PGC) 30804558 Tourette's syndrome Meta-analysis European Overall 4,819/9,488 The first four population stratificationcomponents and any additional populationstratification component that was nominallysignificantly associated with the phenotype 30818990 Substance use disorders Meta-analysis European Overall 1,025,550 Study-specific covariates 37250466 Secondaryoutcome Life satisfaction Meta-analysis European Overall 80,852 Study-specific covariates 30643256 Positive affect Meta-analysis European Overall 410,603 Study-specific covariates 30643256 Neuroticism Meta-analysis European Overall 582,989 Study-specific covariates 30643256 Depressive symptoms Meta-analysis European Overall 1,295,946 Study-specific covariates 30643256 Depressive symptoms(seen a generalpractitioner) UKB European Women 79,976/112,704 Age, age2, and the first 20 PCs Neale lab ### Page 6 Depressive symptoms(seen a generalpractitioner) UKB European Men 43,552/122,461 Age, age2, and the first 20 PCs Neale lab Depressive symptoms(seen a psychiatrist) UKB European Women 23,975/169,269 Age, age2, and the first 20 PCs Neale lab Depressive symptoms(seen a psychiatrist) UKB European Men 17,258/149,033 Age, age2, and the first 20 PCs Neale lab Postpartum depression Meta-analysis European Women 17,339/53,426 Study-specific covariates 37849304 Bipolar disorder I Meta-analysis European Overall 25,060/449,978 The first five PCs and any others as required 34002096 Bipolar disorder II Meta-analysis European Overall 6,781/364,075 The first five PCs and any others as required 34002096 Cannabis use disorder iPSYCH,deCODE,PGC European Overall 14,080/343,726 Five ancestral PCs, data processing waves,and the presence of another psychiatricdisorder (iPSYCH); sex, age, county of origin,population stratification, and relatedness(deCODE); sex and five to ten within-ancestry PCs (PGC) 33096046 Alcohol dependence Meta-analysis European Overall 8,485/20,272 Sex and PCs 30482948 AUDIT (total score) UKB European Overall 121,604 Age, sex, genotyping array, and the first 20PCs 30336701 AUDIT (alcoholconsumption) UKB European Overall 121,604 Age, sex, genotyping array, and the first 20PCs 30336701 AUDIT (alcoholproblems) UKB European Overall 121,604 Age, sex, genotyping array, and the first 20PCs 30336701 Replicationoutcome Major depressive disorder FinnGen R12 European Overall 59,333/434,831 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Bipolar disorder FinnGen R12 European Overall 8,946/434,831 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 ### Page 7 PTSD FinnGen R12 European Overall 3,444/444,414 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Schizophrenia FinnGen R12 European Overall 7,234/484,776 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Anorexia nervosa(including atypical) FinnGen R12 European Overall 2,621/484,901 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Attention deficithyperactivity disorder FinnGen R12 European Overall 4,452/490,708 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Substance abuse FinnGen R12 European Overall 30,806/362,304 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 Alcohol dependence FinnGen R12 European Overall 12,599/468,475 Age, sex, FinnGen chip version 1 or 2, legacygenotyping batch, and the first 10 PCs 36653562 AUDIT, Alcohol Use Disorders Identification Test; CARDIoGRAMplusC4D, Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The CoronaryArtery Disease Genetics; GIANT, Genetic Investigation of ANthropometric Traits; HbA1c, glycated hemoglobin; iPSYCH, Integrative Psychiatric Research; PC, principalcomponent; PCR, polymerase chain reaction; PEER, Probabilistic Estimation of Expression Residuals; PGC, Psychiatric Genomics Consortium; PTSD, post-traumatic stressdisorder; UKB, UK Biobank; UKB-PPP, UK Biobank Pharma Proteomics Project. ### Page 8 eFigure 1. Regional plots for genetic instruments for GLP-1R activation. BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin. ### Page 9 eTable 2. SNP-specific estimates for genetic instruments for GLP-1R activation on BMI (kg/m2) and HbA1c (mmol/mol). Category Phenotype Sex SNP Effectallele Otherallele Effect allelefrequency Beta SE P value F-statistic Primaryanalyses BMI Overall rs17757975 T C 0.846 0.075 0.012 1.6E-10 41.7 BMI Overall rs4714290 T C 0.705 0.054 0.009 2.4E-09 34.7 BMI Women rs17757975 T C 0.845 0.066 0.016 2.3E-05 17.5 BMI Women rs4714290 T C 0.705 0.056 0.012 4.6E-06 21.5 BMI Men rs17757975 T C 0.844 0.089 0.017 1.8E-07 26.4 BMI Men rs4714290 T C 0.704 0.058 0.013 1.1E-05 18.7 HbA1c Overall rs10305518 G T 0.057 0.195 0.034 7.2E-09 33.5 HbA1c Women rs10305518 G T 0.057 0.174 0.045 1.1E-04 14.9 HbA1c Men rs10305518 G T 0.057 0.218 0.051 1.6E-05 18.6 Secondaryanalyses HbA1c Overall rs10305492 G A 0.984 0.403 0.062 1.1E-10 41.7 HbA1c Women rs10305492 G A 0.984 0.270 0.083 1.2E-03 10.5 HbA1c Men rs10305492 G A 0.984 0.556 0.094 3.9E-09 34.7 BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin. ### Page 10 eFigure 2. The associations of genetic instruments for GLP-1R activation with GLP1R expression in the ten most highly expressedtissues. GLP-1R, glucagon-like peptide-1 receptor. rs10305492 was not available in the expression quantitative trait locus data. * denotes p value < 0.05. ### Page 11 eTable 3. SNP-specific estimates for genetic instruments for GLP-1R activation on plasma GLP-1R levels. Category Phenotype SNP Effectallele Otherallele Effect allelefrequency Beta SE P value Primary analyses BMI rs17757975 T C 0.852 -0.001 0.011 0.91 BMI rs4714290 T C 0.715 0.010 0.009 0.23 HbA1c rs10305518 G T 0.057 -0.034 0.017 0.04 Secondary analyses HbA1c rs10305492 G A 0.984 0.001 0.031 0.98 BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin. ### Page 12 eTable 4. MR estimates for the associations of GLP-1R activation with HbA1c (mmol/mol) and BMI (kg/m2). Category Exposure Outcome SNPs Method Beta (95% CI) P value P value(Q) Primary analyses Lower BMI via GLP-1R activation HbA1c 2 IVW -0.32 (-0.74 to 0.11) 0.14 0.10 Lower HbA1c via GLP-1R activation BMI 1 IVW -0.04 (-0.22 to 0.14) 0.67 Secondary analyses Lower HbA1c via GLP-1R activation BMI 1 IVW -0.004 (-0.18 to 0.17) 0.97 BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse variance weighted; MR, Mendelian randomization. ### Page 13 eTable 5. SNP-specific estimates for genetic instruments for BMI (kg/m2) and HbA1c (mmol/mol). Phenotype Sex SNP Effectallele Otherallele Effect allelefrequency Beta SE P value F-statistic BMI Overall rs2803316 A G 0.455 -0.068 0.008 1.9E-16 69.8 BMI Overall rs7535528 A G 0.372 -0.074 0.009 1.6E-17 73.2 BMI Overall rs6577584 T G 0.659 -0.057 0.009 3.4E-11 43.0 BMI Overall rs2791653 A G 0.240 0.064 0.009 1.0E-12 49.0 BMI Overall rs9435739 A G 0.661 -0.052 0.009 9.9E-10 36.7 BMI Overall rs4655141 T C 0.836 -0.083 0.011 6.2E-15 61.8 BMI Overall rs10798888 T G 0.189 0.062 0.011 5.8E-09 34.9 BMI Overall rs12022461 A G 0.167 -0.080 0.011 9.8E-14 57.6 BMI Overall rs7512146 T G 0.527 -0.047 0.008 1.3E-08 32.6 BMI Overall rs11586036 A C 0.935 -0.095 0.017 1.1E-08 32.0 BMI Overall rs11206436 T C 0.893 0.071 0.013 4.7E-08 29.6 BMI Overall rs1707322 A G 0.316 -0.065 0.009 1.6E-14 57.1 BMI Overall rs2984618 T G 0.441 0.079 0.008 3.8E-24 106.3 BMI Overall rs657452 A G 0.404 0.090 0.008 3.2E-30 138.1 BMI Overall rs17425707 T C 0.900 -0.083 0.013 6.2E-10 38.2 BMI Overall rs2481665 T C 0.582 0.077 0.008 3.2E-23 101.3 BMI Overall rs2503185 A G 0.510 0.062 0.008 1.3E-14 58.5 BMI Overall rs3101336 T C 0.383 -0.122 0.008 4.8E-54 252.0 BMI Overall rs12036473 A T 0.618 -0.082 0.008 2.8E-24 101.2 BMI Overall rs12049202 T C 0.188 0.115 0.010 3.3E-29 129.5 BMI Overall rs2166171 T C 0.624 -0.050 0.009 5.5E-09 32.7 BMI Overall rs12034762 T C 0.391 0.060 0.008 6.3E-13 54.1 BMI Overall rs11165643 T C 0.580 0.089 0.008 4.5E-30 133.7 BMI Overall rs10747488 A C 0.780 -0.064 0.010 1.5E-11 44.9 BMI Overall rs17024393 T C 0.969 -0.310 0.024 7.1E-39 172.7 BMI Overall rs197374 T C 0.403 0.068 0.008 3.2E-16 68.8 BMI Overall rs12120851 T C 0.631 -0.056 0.010 2.9E-08 30.5 BMI Overall rs7534091 A G 0.718 -0.058 0.009 6.7E-11 44.4 BMI Overall rs6587552 A G 0.241 0.075 0.010 2.2E-15 61.6 BMI Overall rs3856261 A G 0.498 0.056 0.008 1.1E-11 46.6 BMI Overall rs1750307 A T 0.366 0.062 0.009 2.8E-13 51.4 BMI Overall rs10733051 A G 0.512 0.045 0.008 7.0E-09 33.8 BMI Overall rs12564992 A G 0.888 -0.091 0.012 2.6E-13 52.8 BMI Overall rs543874 A G 0.779 -0.230 0.010 3.1E-125 573.6 BMI Overall rs10920678 A G 0.425 0.072 0.008 7.1E-20 86.7 BMI Overall rs2400414 T C 0.346 -0.061 0.009 5.5E-13 49.0 BMI Overall rs2820295 A G 0.327 0.113 0.009 5.6E-39 170.4 BMI Overall rs10920336 A G 0.533 -0.049 0.008 4.2E-09 35.3 BMI Overall rs1006317 T G 0.127 0.077 0.012 3.7E-10 37.9 BMI Overall rs6661316 T C 0.589 0.058 0.008 1.7E-13 56.3 BMI Overall rs10489615 A G 0.400 0.048 0.008 1.3E-08 33.9 BMI Overall rs946824 T C 0.136 0.095 0.012 4.8E-15 62.1 BMI Overall rs4577313 A G 0.241 0.076 0.010 2.6E-15 62.4 BMI Overall rs13021737 A G 0.157 -0.278 0.010 2.9E-161 757.6 BMI Overall rs10929925 A C 0.411 -0.068 0.008 3.0E-18 78.8 ### Page 14 BMI Overall rs11902450 T C 0.105 0.080 0.013 1.1E-09 38.3 BMI Overall rs10182181 A G 0.505 -0.157 0.008 2.5E-91 417.7 BMI Overall rs1260326 T C 0.391 -0.051 0.008 1.2E-10 39.6 BMI Overall rs17327461 T C 0.446 0.059 0.008 7.6E-14 58.1 BMI Overall rs10185199 A G 0.286 -0.069 0.010 3.2E-13 51.1 BMI Overall rs10169594 T C 0.648 -0.058 0.009 1.3E-11 44.4 BMI Overall rs7561278 T C 0.767 0.081 0.010 4.9E-16 64.8 BMI Overall rs930295 A C 0.155 0.100 0.011 2.0E-19 81.8 BMI Overall rs805412 A G 0.434 -0.047 0.008 1.1E-08 33.2 BMI Overall rs4671328 T G 0.450 0.103 0.008 3.4E-36 158.5 BMI Overall rs6545714 A G 0.611 -0.093 0.008 4.0E-32 147.0 BMI Overall rs2861683 A C 0.597 0.068 0.008 1.9E-16 68.8 BMI Overall rs17020497 A G 0.134 0.067 0.012 2.0E-08 31.4 BMI Overall rs12714199 T C 0.615 -0.068 0.008 3.2E-16 68.8 BMI Overall rs4303732 T C 0.614 0.081 0.008 1.3E-22 98.8 BMI Overall rs264941 A C 0.468 -0.060 0.008 1.8E-13 53.2 BMI Overall rs10197031 T C 0.726 -0.077 0.009 5.0E-18 71.8 BMI Overall rs11884795 A G 0.268 0.054 0.009 1.6E-09 38.7 BMI Overall rs4988235 A G 0.721 0.060 0.008 7.1E-13 53.2 BMI Overall rs17814208 A G 0.758 -0.062 0.010 7.2E-11 41.6 BMI Overall rs16824165 A G 0.116 0.077 0.013 2.2E-09 35.1 BMI Overall rs429343 A G 0.434 0.070 0.008 8.4E-18 73.8 BMI Overall rs2119753 A G 0.623 0.048 0.008 1.0E-08 34.6 BMI Overall rs3764835 A G 0.151 -0.062 0.012 3.8E-08 29.3 BMI Overall rs12692596 T C 0.362 0.058 0.008 1.0E-12 49.8 BMI Overall rs1521527 C G 0.518 -0.049 0.008 1.8E-09 36.0 BMI Overall rs3754963 A T 0.763 0.062 0.009 2.4E-11 46.1 BMI Overall rs2138348 T G 0.284 -0.064 0.009 1.4E-12 49.7 BMI Overall rs2119137 A G 0.662 -0.063 0.009 2.3E-13 53.0 BMI Overall rs7588437 A G 0.366 -0.079 0.008 2.3E-22 94.2 BMI Overall rs6757852 A G 0.499 0.051 0.008 3.8E-10 38.9 BMI Overall rs7593917 A G 0.454 -0.055 0.008 9.7E-13 51.7 BMI Overall rs4482463 A C 0.917 -0.149 0.015 4.8E-23 100.0 BMI Overall rs6715020 T C 0.381 -0.050 0.008 1.3E-09 38.1 BMI Overall rs11692326 T C 0.230 0.071 0.009 1.7E-14 59.9 BMI Overall rs7599312 A G 0.274 -0.087 0.009 1.5E-23 102.2 BMI Overall rs12987009 A T 0.585 -0.052 0.008 1.8E-10 41.1 BMI Overall rs6725931 T C 0.848 0.090 0.012 2.3E-15 60.7 BMI Overall rs4973618 A G 0.662 -0.071 0.009 1.3E-16 67.6 BMI Overall rs6720868 T C 0.308 0.074 0.009 1.8E-17 73.2 BMI Overall rs7568228 C G 0.540 -0.050 0.008 1.0E-09 37.4 BMI Overall rs17535749 A G 0.108 0.076 0.013 3.5E-09 34.7 BMI Overall rs10510419 T G 0.147 -0.081 0.011 2.2E-13 53.4 BMI Overall rs2600226 T C 0.671 -0.056 0.009 1.4E-10 41.5 BMI Overall rs1048637 T G 0.547 -0.045 0.008 2.9E-08 30.6 BMI Overall rs4858193 T C 0.720 0.064 0.009 2.4E-12 49.0 BMI Overall rs6804842 A G 0.430 -0.068 0.008 7.6E-18 77.7 BMI Overall rs11921432 T C 0.891 -0.091 0.013 5.4E-12 49.0 ### Page 15 BMI Overall rs1799923 A G 0.112 -0.108 0.012 1.1E-17 74.2 BMI Overall rs28350 A G 0.172 0.083 0.011 1.1E-14 61.1 BMI Overall rs4017425 T C 0.468 -0.057 0.008 2.9E-12 48.2 BMI Overall rs11713193 A G 0.516 0.118 0.008 3.0E-48 209.4 BMI Overall rs2365389 T C 0.400 -0.081 0.008 6.5E-25 110.3 BMI Overall rs925018 C G 0.667 -0.062 0.008 4.3E-14 58.5 BMI Overall rs11915371 A C 0.802 -0.074 0.010 2.3E-13 53.8 BMI Overall rs12636480 T G 0.351 0.062 0.009 7.0E-13 50.6 BMI Overall rs9827823 T C 0.855 0.087 0.011 3.4E-15 62.6 BMI Overall rs9818122 T C 0.793 -0.110 0.010 4.0E-30 130.0 BMI Overall rs11128021 A G 0.162 -0.087 0.012 1.6E-14 56.9 BMI Overall rs1492014 T C 0.567 -0.082 0.008 1.4E-23 101.2 BMI Overall rs1436344 C G 0.570 0.071 0.008 1.1E-17 74.8 BMI Overall rs7640424 T C 0.311 -0.065 0.009 1.2E-14 56.3 BMI Overall rs17681451 A G 0.076 -0.108 0.015 7.4E-13 52.7 BMI Overall rs6808814 T C 0.734 0.057 0.009 1.3E-09 38.6 BMI Overall rs7631156 A G 0.309 0.103 0.009 3.3E-32 142.7 BMI Overall rs687339 T C 0.770 0.090 0.009 4.3E-22 97.9 BMI Overall rs16851483 T G 0.072 0.169 0.016 4.9E-25 107.2 BMI Overall rs355777 C G 0.398 0.073 0.008 2.1E-18 78.9 BMI Overall rs9826775 A G 0.851 0.075 0.012 6.6E-11 41.7 BMI Overall rs2047648 A T 0.747 -0.064 0.010 7.9E-12 44.2 BMI Overall rs3732927 T C 0.291 0.048 0.008 1.1E-08 33.9 BMI Overall rs12635553 A T 0.486 0.048 0.008 4.1E-09 33.9 BMI Overall rs39654 A G 0.451 -0.078 0.008 1.7E-21 91.9 BMI Overall rs6443750 T C 0.199 -0.073 0.010 7.3E-13 52.4 BMI Overall rs865809 A G 0.225 0.060 0.010 6.5E-10 38.4 BMI Overall rs9816226 A T 0.176 -0.151 0.010 1.4E-50 225.0 BMI Overall rs7616009 A G 0.160 -0.075 0.012 4.3E-11 42.8 BMI Overall rs2051559 T C 0.859 -0.080 0.012 3.8E-11 44.6 BMI Overall rs6818414 T C 0.516 -0.048 0.008 4.6E-09 34.6 BMI Overall rs1477890 A G 0.488 -0.062 0.008 6.1E-14 56.7 BMI Overall rs9291467 T C 0.465 0.068 0.008 4.6E-17 69.8 BMI Overall rs6448587 A C 0.806 0.075 0.011 1.6E-12 50.3 BMI Overall rs337637 A G 0.359 -0.066 0.008 6.2E-16 64.9 BMI Overall rs10938397 A G 0.570 -0.155 0.008 2.4E-86 405.0 BMI Overall rs2271046 A T 0.695 -0.055 0.009 3.0E-10 40.8 BMI Overall rs1492767 T C 0.468 0.046 0.008 3.5E-09 35.3 BMI Overall rs2192158 A G 0.449 0.066 0.008 7.4E-16 64.9 BMI Overall rs1346841 A G 0.412 -0.061 0.008 3.2E-13 54.9 BMI Overall rs10002111 A G 0.223 0.060 0.010 1.3E-09 35.4 BMI Overall rs10033843 A G 0.215 0.067 0.010 1.1E-11 44.4 BMI Overall rs17507682 T G 0.154 0.065 0.012 1.9E-08 31.6 BMI Overall rs4148155 A G 0.887 0.092 0.012 1.3E-13 54.5 BMI Overall rs4286488 A G 0.761 0.058 0.010 1.7E-09 36.6 BMI Overall rs7678054 A G 0.479 -0.048 0.008 4.6E-09 33.9 BMI Overall rs3796432 T G 0.367 -0.054 0.009 2.2E-10 39.4 BMI Overall rs13107325 T C 0.082 0.225 0.015 3.8E-47 213.9 ### Page 16 BMI Overall rs326893 T C 0.581 0.058 0.008 1.9E-12 50.7 BMI Overall rs7696649 A G 0.278 0.056 0.009 4.7E-10 37.3 BMI Overall rs4864201 T C 0.347 0.066 0.008 4.3E-16 64.9 BMI Overall rs1296328 A C 0.446 0.080 0.008 3.5E-22 95.3 BMI Overall rs17367750 T C 0.312 -0.059 0.009 2.0E-11 45.9 BMI Overall rs9992189 C G 0.608 -0.047 0.008 2.0E-08 32.6 BMI Overall rs3914628 T C 0.859 0.079 0.011 6.9E-13 51.5 BMI Overall rs750090 T C 0.626 0.054 0.009 2.5E-10 39.4 BMI Overall rs13110266 A G 0.404 -0.060 0.008 4.0E-14 60.1 BMI Overall rs7685628 A T 0.401 0.049 0.008 6.1E-09 35.3 BMI Overall rs1522569 T G 0.818 0.068 0.011 1.6E-10 41.1 BMI Overall rs1437842 A G 0.491 -0.051 0.008 8.5E-10 38.9 BMI Overall rs4565118 A C 0.502 -0.051 0.009 7.3E-09 34.7 BMI Overall rs698147 A G 0.447 0.056 0.008 9.7E-12 46.6 BMI Overall rs6890310 A G 0.292 -0.057 0.009 3.3E-10 39.2 BMI Overall rs7730004 T C 0.661 0.067 0.009 1.5E-14 59.6 BMI Overall rs7704281 A G 0.046 0.119 0.020 1.2E-09 36.6 BMI Overall rs13186194 T C 0.617 0.048 0.008 2.2E-09 34.6 BMI Overall rs4700608 T C 0.524 -0.075 0.008 4.3E-20 83.1 BMI Overall rs6886740 T C 0.662 0.055 0.009 3.1E-10 40.1 BMI Overall rs1159692 A C 0.475 0.065 0.008 5.5E-15 63.1 BMI Overall rs2112347 T G 0.630 0.133 0.008 1.2E-61 263.6 BMI Overall rs10942267 A G 0.693 0.071 0.009 6.5E-16 67.6 BMI Overall rs2962334 T G 0.027 0.190 0.028 1.8E-11 45.0 BMI Overall rs1501673 A G 0.136 0.139 0.012 2.7E-31 133.6 BMI Overall rs12652212 A G 0.561 -0.063 0.008 1.6E-15 67.0 BMI Overall rs7713317 A G 0.720 -0.080 0.009 2.0E-20 85.0 BMI Overall rs6882366 T C 0.396 -0.063 0.008 4.4E-14 59.4 BMI Overall rs11739877 T C 0.623 0.056 0.009 4.0E-11 41.5 BMI Overall rs6888194 T C 0.844 -0.061 0.011 3.6E-08 30.5 BMI Overall rs40067 A G 0.170 -0.121 0.011 9.7E-29 120.0 BMI Overall rs459552 A T 0.775 -0.064 0.009 8.4E-12 49.0 BMI Overall rs6893539 A C 0.698 -0.059 0.009 6.2E-11 41.2 BMI Overall rs6864049 A G 0.489 -0.058 0.008 1.5E-13 57.2 BMI Overall rs6886072 T C 0.467 -0.048 0.008 4.1E-09 34.6 BMI Overall rs13174863 A G 0.854 -0.095 0.011 1.9E-17 73.4 BMI Overall rs17405603 A T 0.706 -0.060 0.009 4.4E-11 43.3 BMI Overall rs2973157 A G 0.671 -0.054 0.010 4.2E-08 28.4 BMI Overall rs7715256 T G 0.564 -0.076 0.008 4.0E-22 97.5 BMI Overall rs7734385 A G 0.445 -0.049 0.008 6.1E-10 39.8 BMI Overall rs2861089 A T 0.381 0.050 0.008 1.5E-09 38.1 BMI Overall rs7727781 T C 0.516 0.045 0.008 4.3E-08 29.9 BMI Overall rs2053682 A C 0.678 0.082 0.009 2.6E-20 89.2 BMI Overall rs6556301 T G 0.371 -0.054 0.008 8.1E-11 44.2 BMI Overall rs2228213 A G 0.337 -0.069 0.008 5.5E-17 71.8 BMI Overall rs11757278 T C 0.696 0.064 0.009 6.9E-13 49.0 BMI Overall rs3806114 A G 0.692 -0.058 0.009 1.5E-11 44.4 BMI Overall rs2066295 A G 0.758 0.068 0.010 2.3E-12 50.4 ### Page 17 BMI Overall rs3115667 T C 0.282 -0.086 0.009 5.9E-21 88.8 BMI Overall rs2281819 A T 0.229 -0.074 0.010 2.1E-14 59.3 BMI Overall rs2744974 T C 0.324 0.125 0.008 1.3E-51 235.7 BMI Overall rs2436728 A G 0.407 0.091 0.008 2.0E-29 123.6 BMI Overall rs1358980 T C 0.474 -0.062 0.008 5.2E-15 57.6 BMI Overall rs2206277 T C 0.156 0.196 0.010 1.8E-83 377.5 BMI Overall rs1327259 A G 0.610 0.075 0.008 1.5E-19 85.3 BMI Overall rs6915002 T C 0.411 0.048 0.008 8.7E-09 33.9 BMI Overall rs9370410 A G 0.729 0.050 0.009 2.6E-08 30.5 BMI Overall rs2622274 T G 0.455 -0.051 0.008 3.2E-10 39.6 BMI Overall rs13213867 A G 0.803 0.059 0.011 1.0E-08 31.3 BMI Overall rs6921533 T C 0.293 0.050 0.009 1.4E-08 33.4 BMI Overall rs9294260 A G 0.469 0.067 0.008 8.2E-18 76.6 BMI Overall rs6909685 T C 0.330 -0.072 0.009 2.8E-16 68.5 BMI Overall rs9320823 T C 0.412 -0.079 0.008 2.1E-21 94.2 BMI Overall rs12530388 A C 0.474 0.048 0.008 4.2E-09 34.6 BMI Overall rs156201 C G 0.746 0.060 0.009 1.6E-10 42.6 BMI Overall rs768023 A G 0.603 0.077 0.008 1.1E-22 101.3 BMI Overall rs2357760 A G 0.674 0.069 0.008 2.1E-16 70.8 BMI Overall rs2875762 C G 0.252 0.062 0.010 1.1E-10 41.6 BMI Overall rs1268065 A G 0.500 -0.048 0.008 7.1E-10 39.1 BMI Overall rs9375702 T C 0.679 -0.051 0.009 5.5E-09 34.7 BMI Overall rs2246012 T C 0.851 -0.077 0.011 1.2E-13 53.6 BMI Overall rs6922607 A G 0.808 -0.062 0.011 1.9E-09 34.9 BMI Overall rs765875 T C 0.469 -0.063 0.008 1.1E-14 60.3 BMI Overall rs7760482 A G 0.616 -0.049 0.009 6.2E-09 32.1 BMI Overall rs12527426 A G 0.300 0.072 0.009 5.5E-16 62.3 BMI Overall rs9478496 T C 0.845 -0.075 0.011 8.2E-12 46.6 BMI Overall rs13191362 A G 0.857 0.113 0.012 4.1E-21 88.4 BMI Overall rs9458814 T C 0.771 -0.054 0.010 2.3E-08 31.4 BMI Overall rs6461115 A G 0.762 0.064 0.009 1.5E-12 49.7 BMI Overall rs6463489 T C 0.096 0.080 0.012 2.5E-10 41.3 BMI Overall rs7779296 A G 0.716 -0.050 0.009 4.6E-09 32.7 BMI Overall rs4307239 A G 0.536 -0.055 0.008 1.5E-11 45.8 BMI Overall rs213518 T C 0.850 -0.074 0.012 2.5E-10 40.6 BMI Overall rs215669 A G 0.602 -0.072 0.008 8.9E-18 76.8 BMI Overall rs2108719 A G 0.727 0.051 0.009 2.3E-08 31.7 BMI Overall rs217433 T C 0.803 -0.055 0.010 3.0E-08 30.0 BMI Overall rs2289379 T C 0.392 -0.066 0.009 7.0E-15 57.9 BMI Overall rs10499694 A G 0.494 0.062 0.008 1.3E-15 66.0 BMI Overall rs11772246 T C 0.823 0.070 0.011 3.7E-11 43.4 BMI Overall rs17207196 T C 0.420 -0.106 0.008 1.6E-36 167.5 BMI Overall rs17149254 T C 0.205 0.114 0.011 3.0E-25 107.1 BMI Overall rs6973656 A G 0.584 -0.049 0.008 6.3E-09 35.3 BMI Overall rs1965529 A G 0.773 0.077 0.011 7.7E-14 53.6 BMI Overall rs274628 A C 0.337 -0.049 0.009 1.4E-08 32.1 BMI Overall rs2283006 A G 0.488 0.063 0.008 8.1E-15 60.3 BMI Overall rs13240600 A G 0.834 0.087 0.011 7.9E-16 66.9 ### Page 18 BMI Overall rs1721447 T G 0.510 -0.048 0.008 3.8E-09 34.6 BMI Overall rs2396625 A T 0.418 -0.085 0.008 2.8E-24 107.2 BMI Overall rs13245051 A G 0.456 0.072 0.008 1.1E-18 77.9 BMI Overall rs10261050 T C 0.475 0.054 0.008 4.5E-11 44.2 BMI Overall rs2283093 T C 0.195 0.058 0.010 1.1E-08 33.2 BMI Overall rs7802342 T G 0.705 -0.060 0.009 6.2E-11 42.6 BMI Overall rs17160760 A T 0.105 -0.079 0.013 1.3E-09 37.3 BMI Overall rs11773362 T C 0.340 -0.050 0.009 6.4E-09 34.0 BMI Overall rs2907948 A G 0.244 -0.070 0.009 1.9E-14 58.2 BMI Overall rs1700082 C G 0.659 0.045 0.008 3.4E-08 30.6 BMI Overall rs4240673 T C 0.455 0.084 0.008 1.6E-26 119.6 BMI Overall rs13263601 A C 0.659 -0.070 0.009 4.9E-16 64.9 BMI Overall rs10110189 T C 0.106 -0.075 0.013 2.2E-08 31.0 BMI Overall rs10101364 T C 0.680 0.058 0.009 5.6E-11 44.4 BMI Overall rs1421334 A C 0.455 0.065 0.008 3.1E-15 63.1 BMI Overall rs2466103 T G 0.693 -0.058 0.009 8.0E-12 45.2 BMI Overall rs6468266 A T 0.418 -0.054 0.008 7.7E-11 44.2 BMI Overall rs12681792 A C 0.202 0.072 0.010 2.9E-12 51.0 BMI Overall rs12334877 A G 0.191 -0.069 0.010 2.2E-11 47.0 BMI Overall rs1431659 A G 0.274 0.092 0.009 2.3E-23 101.1 BMI Overall rs17405819 T C 0.685 0.101 0.009 6.0E-33 137.4 BMI Overall rs2196618 A G 0.263 -0.066 0.009 1.5E-12 52.0 BMI Overall rs2120710 A G 0.653 0.049 0.009 2.0E-08 31.5 BMI Overall rs12680842 A G 0.684 0.068 0.008 3.4E-16 69.8 BMI Overall rs6469351 T C 0.672 0.053 0.009 3.7E-10 38.0 BMI Overall rs3808477 T C 0.274 -0.087 0.009 8.7E-22 91.8 BMI Overall rs11781699 T C 0.813 -0.068 0.010 1.6E-11 45.1 BMI Overall rs6470144 T G 0.650 0.047 0.009 3.1E-08 29.6 BMI Overall rs7842934 T C 0.921 -0.086 0.015 1.5E-08 33.0 BMI Overall rs305256 T C 0.226 -0.055 0.010 2.8E-08 30.0 BMI Overall rs16906838 T C 0.049 -0.119 0.019 4.3E-10 38.1 BMI Overall rs11782074 T G 0.368 0.060 0.009 4.2E-12 47.5 BMI Overall rs10099330 A G 0.538 -0.057 0.008 3.2E-12 49.0 BMI Overall rs10975933 C G 0.663 0.055 0.009 2.1E-10 40.1 BMI Overall rs1948080 T G 0.630 0.065 0.009 1.1E-14 57.1 BMI Overall rs10961649 T C 0.324 0.050 0.009 1.5E-08 33.4 BMI Overall rs4740619 T C 0.544 0.091 0.008 3.1E-31 139.5 BMI Overall rs10962550 C G 0.176 0.089 0.011 5.7E-17 71.5 BMI Overall rs10811868 A G 0.320 -0.048 0.009 3.2E-08 30.9 BMI Overall rs10968114 A C 0.533 0.054 0.008 3.3E-11 44.2 BMI Overall rs1412235 C G 0.315 0.114 0.008 2.3E-42 194.4 BMI Overall rs10121187 C G 0.509 0.049 0.008 2.0E-09 36.0 BMI Overall rs2275003 A G 0.501 0.053 0.008 9.4E-12 48.1 BMI Overall rs13296413 T C 0.381 -0.071 0.008 2.5E-17 75.8 BMI Overall rs2134858 T C 0.512 -0.056 0.008 5.9E-12 47.4 BMI Overall rs7861160 T C 0.594 0.046 0.008 3.7E-08 31.2 BMI Overall rs1999433 T C 0.440 -0.051 0.008 2.9E-10 39.6 BMI Overall rs2777768 A G 0.723 0.057 0.009 6.4E-10 39.2 ### Page 19 BMI Overall rs7357754 A G 0.499 -0.058 0.008 1.8E-12 49.8 BMI Overall rs10992867 A G 0.269 0.078 0.009 3.2E-17 72.7 BMI Overall rs7025938 C G 0.680 -0.078 0.009 1.5E-19 81.0 BMI Overall rs7024334 T G 0.225 0.065 0.010 4.7E-12 45.6 BMI Overall rs1928295 T C 0.571 0.064 0.008 2.2E-16 70.1 BMI Overall rs1877875 T C 0.434 -0.052 0.008 2.5E-10 41.1 BMI Overall rs10733682 A G 0.459 0.071 0.008 1.8E-19 85.6 BMI Overall rs2267958 A G 0.509 -0.062 0.009 2.0E-13 52.2 BMI Overall rs4740383 A G 0.419 0.063 0.009 7.0E-14 53.0 BMI Overall rs10858334 C G 0.848 -0.071 0.012 4.9E-09 35.0 BMI Overall rs7907470 A G 0.916 -0.085 0.015 7.4E-09 32.6 BMI Overall rs7893571 T G 0.674 0.060 0.009 5.8E-12 48.2 BMI Overall rs7084454 A G 0.309 0.095 0.009 4.5E-27 121.0 BMI Overall rs10829164 T C 0.147 0.073 0.012 2.4E-10 39.6 BMI Overall rs4097319 T G 0.564 0.051 0.008 4.3E-10 39.6 BMI Overall rs12765914 T C 0.080 0.109 0.015 2.0E-13 53.1 BMI Overall rs1624134 C G 0.393 0.048 0.008 6.5E-09 34.6 BMI Overall rs12259464 A G 0.481 0.052 0.008 1.5E-10 41.1 BMI Overall rs10761785 T G 0.514 -0.064 0.008 3.5E-16 69.1 BMI Overall rs12098284 T C 0.121 0.088 0.012 9.9E-13 50.1 BMI Overall rs11001259 A T 0.177 -0.066 0.012 1.2E-08 33.1 BMI Overall rs7899106 A G 0.950 -0.157 0.018 1.7E-18 78.1 BMI Overall rs10788494 C G 0.484 0.063 0.008 5.5E-15 60.3 BMI Overall rs2439823 A G 0.451 -0.079 0.008 6.5E-22 94.2 BMI Overall rs17094222 T C 0.791 -0.083 0.010 4.0E-18 74.8 BMI Overall rs1886276 A G 0.571 -0.052 0.008 3.0E-10 40.4 BMI Overall rs7903146 T C 0.279 -0.086 0.009 1.7E-23 97.8 BMI Overall rs2257791 A G 0.756 -0.067 0.010 1.6E-12 48.3 BMI Overall rs845084 A G 0.267 0.065 0.009 3.2E-12 51.2 BMI Overall rs17636031 T C 0.724 -0.074 0.009 3.9E-17 73.2 BMI Overall rs4880341 T C 0.573 -0.062 0.008 3.1E-14 58.5 BMI Overall rs12416812 A G 0.507 0.051 0.008 5.2E-11 43.9 BMI Overall rs4256980 C G 0.331 -0.090 0.008 8.6E-29 121.0 BMI Overall rs900144 T C 0.578 0.071 0.008 1.5E-18 75.8 BMI Overall rs2074314 T C 0.636 0.050 0.008 1.4E-09 38.1 BMI Overall rs6265 T C 0.184 -0.199 0.010 7.4E-89 386.8 BMI Overall rs570463 A C 0.327 -0.058 0.009 4.3E-11 45.2 BMI Overall rs11030618 T C 0.579 0.053 0.008 1.7E-10 41.9 BMI Overall rs2065418 T G 0.646 0.067 0.009 6.1E-15 59.6 BMI Overall rs2862996 T G 0.701 -0.104 0.008 3.6E-35 161.4 BMI Overall rs10838202 C G 0.556 0.054 0.008 5.5E-11 44.2 BMI Overall rs10742752 T C 0.376 -0.059 0.008 1.2E-13 52.3 BMI Overall rs7124681 A C 0.416 0.124 0.008 4.0E-55 258.0 BMI Overall rs6591407 A C 0.198 -0.060 0.010 3.6E-09 34.9 BMI Overall rs562664 T C 0.187 -0.066 0.011 4.2E-10 39.3 BMI Overall rs7102454 T C 0.644 -0.081 0.009 3.8E-21 87.1 BMI Overall rs592483 T C 0.593 -0.066 0.008 1.5E-16 64.9 BMI Overall rs737185 A G 0.781 0.066 0.010 4.2E-11 42.6 ### Page 20 BMI Overall rs349088 A C 0.478 -0.062 0.008 3.5E-14 58.5 BMI Overall rs10741329 A G 0.694 0.055 0.009 3.9E-10 40.8 BMI Overall rs3019466 T C 0.168 -0.062 0.012 4.9E-08 28.4 BMI Overall rs2605603 A G 0.481 -0.050 0.008 2.0E-10 41.4 BMI Overall rs4937870 A G 0.694 0.054 0.009 1.6E-09 34.7 BMI Overall rs10891549 T C 0.465 0.046 0.008 1.9E-08 31.2 BMI Overall rs12286929 A G 0.501 -0.085 0.008 1.9E-27 122.4 BMI Overall rs3825061 T C 0.386 0.067 0.008 6.1E-16 67.8 BMI Overall rs6589936 A C 0.387 0.054 0.009 2.2E-10 38.7 BMI Overall rs7944782 T G 0.502 -0.069 0.008 3.6E-17 71.8 BMI Overall rs2007518 A G 0.562 -0.062 0.008 2.0E-14 58.5 BMI Overall rs1941213 A C 0.711 0.052 0.009 1.6E-08 32.3 BMI Overall rs329651 T G 0.806 0.077 0.010 2.1E-14 58.0 BMI Overall rs12364470 T G 0.854 -0.090 0.011 2.2E-17 72.3 BMI Overall rs11611246 T G 0.199 0.107 0.010 2.0E-28 124.3 BMI Overall rs765125 T C 0.586 -0.047 0.008 1.3E-08 33.2 BMI Overall rs10772983 T C 0.539 -0.048 0.008 6.2E-10 39.1 BMI Overall rs11044430 A T 0.844 0.077 0.011 3.8E-12 49.0 BMI Overall rs11046972 T C 0.071 0.085 0.015 3.7E-08 30.3 BMI Overall rs10842240 C G 0.126 0.094 0.012 1.2E-14 60.8 BMI Overall rs11170468 A C 0.783 0.062 0.009 1.1E-11 46.8 BMI Overall rs1350430 T C 0.533 -0.060 0.008 2.1E-13 54.1 BMI Overall rs7138803 A G 0.387 0.143 0.008 3.1E-71 305.2 BMI Overall rs2271189 A G 0.396 -0.068 0.009 9.3E-16 61.4 BMI Overall rs7975187 A G 0.771 -0.066 0.010 3.9E-11 42.6 BMI Overall rs650198 T C 0.729 -0.066 0.009 6.4E-13 52.0 BMI Overall rs11115176 T C 0.784 0.063 0.009 6.8E-12 47.5 BMI Overall rs10506971 A G 0.552 -0.068 0.008 4.7E-17 69.8 BMI Overall rs11105839 A T 0.373 -0.054 0.008 1.2E-11 44.2 BMI Overall rs2712665 T C 0.697 -0.052 0.009 5.4E-09 32.3 BMI Overall rs6539064 C G 0.747 0.093 0.009 1.1E-23 104.3 BMI Overall rs1860561 A G 0.209 0.076 0.009 1.7E-16 70.0 BMI Overall rs11066188 A G 0.376 -0.055 0.008 3.1E-12 50.8 BMI Overall rs2707183 T G 0.532 -0.045 0.008 4.9E-08 29.9 BMI Overall rs11615578 T C 0.258 0.056 0.010 3.0E-09 34.2 BMI Overall rs12369179 T C 0.085 -0.163 0.015 2.3E-28 120.3 BMI Overall rs7306544 T C 0.881 -0.068 0.012 4.0E-08 29.8 BMI Overall rs11614340 T C 0.707 -0.056 0.009 1.9E-10 42.3 BMI Overall rs9512648 A G 0.474 0.046 0.008 4.1E-08 31.2 BMI Overall rs7323 C G 0.268 -0.080 0.009 2.2E-18 76.3 BMI Overall rs4771218 A G 0.624 -0.068 0.009 3.2E-15 61.4 BMI Overall rs9595908 T C 0.643 0.074 0.008 3.7E-20 82.1 BMI Overall rs9603697 T C 0.318 0.064 0.009 1.7E-13 55.4 BMI Overall rs12429545 A G 0.122 0.150 0.012 1.4E-37 170.1 BMI Overall rs962796 T C 0.194 0.067 0.010 1.9E-11 44.4 BMI Overall rs9569777 T G 0.187 -0.097 0.010 3.4E-21 91.6 BMI Overall rs9527895 T C 0.819 -0.076 0.011 3.7E-12 47.2 BMI Overall rs8181823 A C 0.234 -0.060 0.010 4.4E-10 39.1 ### Page 21 BMI Overall rs9599161 T C 0.570 0.047 0.008 2.3E-09 37.5 BMI Overall rs1441264 A G 0.585 0.084 0.008 7.6E-25 104.8 BMI Overall rs9602902 T C 0.379 0.064 0.008 1.6E-14 62.1 BMI Overall rs1927790 T C 0.606 -0.067 0.008 1.6E-17 76.6 BMI Overall rs9168 A C 0.275 -0.067 0.009 1.1E-13 53.5 BMI Overall rs9559022 A G 0.816 -0.058 0.011 4.9E-08 30.3 BMI Overall rs1536053 T C 0.310 -0.059 0.009 8.0E-11 41.2 BMI Overall rs12868881 A T 0.407 0.066 0.008 1.4E-15 65.9 BMI Overall rs10132280 A C 0.311 -0.103 0.009 2.3E-33 141.3 BMI Overall rs4981693 A G 0.774 0.097 0.010 7.9E-24 102.0 BMI Overall rs225882 T C 0.751 0.054 0.009 8.6E-10 39.4 BMI Overall rs1958898 C G 0.210 -0.070 0.010 4.2E-12 48.3 BMI Overall rs4900714 T G 0.478 0.072 0.008 1.0E-18 77.9 BMI Overall rs217671 A G 0.726 -0.072 0.009 4.1E-15 62.3 BMI Overall rs4430672 T C 0.196 0.060 0.010 5.0E-09 34.9 BMI Overall rs3902951 T G 0.769 -0.064 0.009 2.9E-12 49.7 BMI Overall rs17182027 A G 0.565 -0.053 0.008 1.5E-10 41.9 BMI Overall rs7144011 T G 0.233 0.126 0.010 2.4E-40 172.9 BMI Overall rs4517716 C G 0.792 -0.056 0.010 4.3E-09 34.2 BMI Overall rs12888545 A G 0.746 -0.064 0.010 1.8E-11 44.2 BMI Overall rs1951455 T C 0.281 -0.071 0.009 6.0E-15 60.7 BMI Overall rs9989141 T C 0.618 0.081 0.008 8.2E-23 97.7 BMI Overall rs8008285 T C 0.849 -0.065 0.012 1.7E-08 31.6 BMI Overall rs7161194 A G 0.344 0.091 0.009 2.2E-24 100.0 BMI Overall rs4906263 C G 0.656 -0.085 0.009 8.1E-23 95.6 BMI Overall rs2273175 T C 0.679 -0.058 0.009 3.7E-11 45.2 BMI Overall rs12594043 C G 0.521 0.049 0.008 1.3E-09 36.0 BMI Overall rs7172627 A G 0.523 -0.055 0.008 1.8E-11 45.0 BMI Overall rs11636611 T C 0.498 0.050 0.008 8.9E-10 37.4 BMI Overall rs9944219 A G 0.604 -0.057 0.008 8.1E-13 49.0 BMI Overall rs12912198 T C 0.273 -0.048 0.009 3.4E-08 30.9 BMI Overall rs6493498 T C 0.447 0.066 0.008 4.8E-17 73.3 BMI Overall rs10518694 A C 0.139 0.069 0.012 3.4E-09 36.0 BMI Overall rs12439632 C G 0.168 0.070 0.011 3.7E-10 39.7 BMI Overall rs339991 A G 0.420 -0.060 0.008 3.5E-13 54.1 BMI Overall rs1559673 A C 0.969 0.173 0.024 2.2E-13 53.7 BMI Overall rs2241423 A G 0.229 -0.143 0.009 3.6E-54 246.0 BMI Overall rs7171864 A G 0.694 0.063 0.008 2.6E-14 60.3 BMI Overall rs2470893 T C 0.305 0.051 0.008 9.4E-10 39.6 BMI Overall rs12914623 C G 0.272 -0.076 0.009 2.0E-16 70.0 BMI Overall rs16946314 A G 0.212 -0.066 0.010 6.9E-11 42.6 BMI Overall rs11633626 A C 0.631 -0.075 0.009 7.3E-19 76.1 BMI Overall rs6496248 A T 0.635 0.050 0.009 2.9E-09 33.4 BMI Overall rs2715423 A G 0.281 -0.055 0.009 1.9E-09 36.6 BMI Overall rs214249 T G 0.607 0.066 0.008 2.7E-15 65.9 BMI Overall rs12448257 A G 0.219 0.077 0.010 9.0E-16 64.8 BMI Overall rs879620 T C 0.597 0.109 0.008 8.4E-39 176.7 BMI Overall rs2058527 T G 0.272 -0.055 0.009 1.8E-09 36.6 ### Page 22 BMI Overall rs9926784 T C 0.801 0.114 0.010 1.1E-30 127.4 BMI Overall rs194809 A G 0.187 0.061 0.011 4.9E-09 32.8 BMI Overall rs2342892 T G 0.486 0.061 0.008 1.3E-13 54.9 BMI Overall rs7498665 A G 0.618 -0.137 0.008 1.1E-66 281.1 BMI Overall rs3814883 T C 0.480 0.109 0.008 1.5E-40 178.3 BMI Overall rs2193101 C G 0.195 0.068 0.010 3.3E-11 45.7 BMI Overall rs1477199 A G 0.843 -0.106 0.011 5.1E-21 92.3 BMI Overall rs9922708 T C 0.440 0.321 0.008 0.0E+00 1743.1 BMI Overall rs2962449 T C 0.471 0.053 0.008 6.7E-11 42.6 BMI Overall rs889398 T C 0.415 -0.094 0.008 3.2E-32 148.5 BMI Overall rs17604662 A G 0.890 -0.086 0.013 1.0E-10 40.9 BMI Overall rs756717 A G 0.394 -0.064 0.008 2.4E-15 62.1 BMI Overall rs4390583 A C 0.571 -0.048 0.009 1.6E-08 30.9 BMI Overall rs12922346 C G 0.264 0.064 0.010 1.5E-11 44.2 BMI Overall rs7206608 C G 0.675 -0.062 0.009 1.2E-12 52.2 BMI Overall rs3923783 A C 0.178 -0.107 0.011 4.1E-23 101.8 BMI Overall rs11078883 C G 0.654 -0.061 0.009 1.3E-12 49.0 BMI Overall rs5862 A G 0.542 -0.049 0.008 2.3E-09 36.0 BMI Overall rs1075901 T C 0.452 -0.057 0.008 4.4E-13 54.4 BMI Overall rs4986044 T C 0.455 -0.085 0.008 1.3E-27 122.4 BMI Overall rs8065172 A G 0.238 -0.060 0.010 5.3E-10 38.4 BMI Overall rs12150665 T C 0.593 0.081 0.008 1.7E-24 110.3 BMI Overall rs6607337 T C 0.298 -0.060 0.009 2.5E-11 42.6 BMI Overall rs7222349 A G 0.356 0.048 0.009 1.7E-08 30.9 BMI Overall rs208015 T C 0.070 0.169 0.016 7.2E-26 113.8 BMI Overall rs7207087 C G 0.684 0.062 0.009 1.8E-12 52.2 BMI Overall rs11649864 A G 0.086 0.092 0.014 2.5E-10 41.0 BMI Overall rs12602912 T C 0.212 0.080 0.010 2.9E-16 68.9 BMI Overall rs312750 A G 0.499 0.047 0.008 2.6E-09 36.8 BMI Overall rs12939549 A G 0.557 0.087 0.008 3.7E-28 126.6 BMI Overall rs4075482 A C 0.368 -0.063 0.009 2.0E-13 53.8 BMI Overall rs8097672 A T 0.855 -0.100 0.012 3.3E-18 75.8 BMI Overall rs477805 A G 0.204 -0.064 0.010 3.3E-10 40.7 BMI Overall rs891387 T C 0.495 0.100 0.008 9.3E-35 149.7 BMI Overall rs1945160 A G 0.382 -0.050 0.009 5.7E-09 33.4 BMI Overall rs1941696 A G 0.517 0.054 0.008 4.7E-11 43.4 BMI Overall rs474605 A G 0.468 -0.060 0.008 2.7E-13 54.1 BMI Overall rs1356506 T C 0.629 0.066 0.009 8.4E-15 57.9 BMI Overall rs2612576 A T 0.295 -0.052 0.009 8.5E-09 32.3 BMI Overall rs784257 T C 0.188 -0.071 0.011 3.1E-11 44.6 BMI Overall rs9951619 T G 0.224 -0.073 0.009 2.3E-15 64.0 BMI Overall rs6567160 T C 0.752 -0.265 0.009 7.8E-184 844.1 BMI Overall rs17066856 T C 0.892 0.168 0.013 7.1E-38 168.0 BMI Overall rs543892 A G 0.608 0.049 0.009 7.0E-09 31.5 BMI Overall rs17783165 T C 0.671 -0.062 0.008 2.7E-13 56.7 BMI Overall rs11150911 A C 0.285 0.057 0.009 3.7E-11 43.0 BMI Overall rs12981256 A G 0.528 0.073 0.008 1.4E-18 78.9 BMI Overall rs895330 C G 0.806 0.094 0.011 1.6E-19 79.4 ### Page 23 BMI Overall rs273512 T C 0.409 0.075 0.009 4.5E-19 75.1 BMI Overall rs17724992 A G 0.720 0.083 0.009 5.2E-21 91.3 BMI Overall rs7258722 A T 0.413 -0.096 0.008 1.8E-30 138.4 BMI Overall rs12611148 A C 0.143 -0.066 0.012 1.4E-08 32.6 BMI Overall rs12462975 A G 0.324 0.093 0.009 1.5E-25 115.0 BMI Overall rs7245985 T G 0.796 0.057 0.010 1.9E-08 32.1 BMI Overall rs11882409 A C 0.303 0.058 0.009 3.3E-10 40.6 BMI Overall rs185350 T C 0.490 0.066 0.008 9.1E-17 73.3 BMI Overall rs769449 A G 0.107 -0.124 0.013 4.4E-21 91.3 BMI Overall rs11672660 T C 0.187 -0.162 0.010 6.8E-60 259.1 BMI Overall rs9304665 A T 0.742 0.111 0.010 2.2E-31 132.3 BMI Overall rs12608738 A G 0.712 0.061 0.009 3.5E-11 44.7 BMI Overall rs1884389 T C 0.439 -0.052 0.008 3.7E-10 40.4 BMI Overall rs4813619 T G 0.531 -0.051 0.009 1.7E-09 34.7 BMI Overall rs1884897 A G 0.375 -0.088 0.008 2.7E-28 117.1 BMI Overall rs2423668 T C 0.420 0.051 0.009 7.8E-09 34.7 BMI Overall rs852056 T C 0.254 0.059 0.009 2.1E-10 41.9 BMI Overall rs1409818 T C 0.107 0.094 0.013 2.6E-12 48.5 BMI Overall rs8122855 A G 0.338 0.066 0.009 4.1E-14 57.9 BMI Overall rs6059578 C G 0.668 0.050 0.009 6.0E-09 33.4 BMI Overall rs16989232 A G 0.386 0.055 0.008 6.2E-12 45.8 BMI Overall rs11904898 A G 0.234 -0.065 0.010 3.2E-11 46.2 BMI Overall rs2143624 A G 0.361 0.045 0.008 2.1E-08 30.6 BMI Overall rs17201143 T C 0.305 -0.054 0.009 1.1E-09 38.7 BMI Overall rs17806224 A G 0.181 -0.125 0.011 7.9E-32 139.7 BMI Overall rs1304549 A G 0.226 -0.057 0.010 1.4E-08 31.6 BMI Overall rs6010784 T C 0.506 0.051 0.008 6.9E-11 43.9 BMI Overall rs6512302 C G 0.739 0.064 0.010 1.5E-11 44.9 BMI Overall rs2064044 A C 0.806 -0.059 0.010 1.0E-08 34.3 BMI Overall rs2832283 A G 0.225 0.055 0.010 4.7E-09 33.1 BMI Overall rs13047416 C G 0.626 0.073 0.009 6.9E-18 71.3 BMI Overall rs13049280 C G 0.643 0.050 0.009 7.0E-09 32.7 BMI Overall rs2183588 A G 0.345 -0.055 0.009 1.9E-10 40.1 BMI Overall rs427943 A C 0.429 -0.085 0.008 3.6E-25 108.4 BMI Overall rs11538 A G 0.828 -0.066 0.011 1.1E-09 36.0 BMI Overall rs2238799 A G 0.619 0.049 0.009 8.6E-09 32.1 BMI Overall rs12628891 T C 0.319 -0.055 0.009 5.9E-10 36.6 BMI Overall rs12628051 T C 0.641 0.077 0.009 2.9E-19 80.0 BMI Overall rs738140 A G 0.710 0.062 0.009 3.1E-12 51.4 BMI Women rs12044597 A G 0.496 -0.066 0.011 2.3E-10 39.3 BMI Women rs4648360 T C 0.447 -0.061 0.011 6.3E-09 33.3 BMI Women rs309517 A T 0.670 -0.064 0.012 2.5E-08 30.7 BMI Women rs12027258 T C 0.835 0.080 0.014 4.7E-08 30.6 BMI Women rs13374459 T C 0.610 -0.065 0.011 8.2E-09 34.5 BMI Women rs2984618 T G 0.443 0.080 0.011 2.2E-14 57.6 BMI Women rs657452 A G 0.405 0.098 0.011 1.1E-19 85.1 BMI Women rs17424278 A C 0.903 -0.101 0.018 3.7E-08 30.5 BMI Women rs1013293 A G 0.411 -0.074 0.011 2.2E-11 44.8 ### Page 24 BMI Women rs2568958 A G 0.619 0.109 0.011 1.3E-24 106.5 BMI Women rs6669189 T C 0.405 0.101 0.011 4.7E-21 91.1 BMI Women rs12729914 T C 0.830 -0.115 0.013 8.6E-18 73.5 BMI Women rs2166171 T C 0.623 -0.066 0.012 7.2E-09 32.6 BMI Women rs11165643 T C 0.579 0.087 0.011 1.7E-16 67.7 BMI Women rs4421623 T G 0.210 0.088 0.013 1.1E-11 46.4 BMI Women rs7550711 T C 0.028 0.308 0.033 3.4E-21 88.9 BMI Women rs197374 T C 0.405 0.082 0.011 2.8E-13 55.3 BMI Women rs3738476 A C 0.877 -0.094 0.017 2.2E-08 31.0 BMI Women rs11264483 C G 0.588 0.074 0.012 7.6E-11 41.2 BMI Women rs12564992 A G 0.888 -0.100 0.017 2.4E-09 35.0 BMI Women rs543874 A G 0.777 -0.277 0.013 8.7E-100 455.1 BMI Women rs10920678 A G 0.424 0.078 0.011 7.5E-14 54.9 BMI Women rs10801377 C G 0.420 0.071 0.011 1.9E-10 41.4 BMI Women rs2820295 A G 0.325 0.103 0.012 8.0E-19 79.5 BMI Women rs17014375 T G 0.870 -0.091 0.016 1.5E-08 31.2 BMI Women rs12042959 A G 0.865 0.093 0.015 2.3E-09 36.8 BMI Women rs6548237 A C 0.160 -0.277 0.014 4.4E-89 394.5 BMI Women rs7571496 A G 0.743 0.070 0.012 1.4E-08 31.1 BMI Women rs7601870 A G 0.453 -0.063 0.011 1.2E-08 32.9 BMI Women rs10182181 A G 0.505 -0.174 0.011 5.0E-63 270.8 BMI Women rs10048652 T C 0.450 0.065 0.011 3.5E-09 34.5 BMI Women rs579119 T C 0.670 0.069 0.011 6.7E-10 39.2 BMI Women rs2346882 A G 0.335 -0.076 0.012 6.6E-11 43.3 BMI Women rs7582359 A G 0.331 -0.080 0.012 1.0E-11 44.6 BMI Women rs1861412 A G 0.423 -0.103 0.011 9.1E-21 87.4 BMI Women rs6728037 A G 0.386 0.100 0.011 6.5E-19 81.0 BMI Women rs11678302 T G 0.787 -0.081 0.014 7.2E-09 33.6 BMI Women rs12714199 T C 0.615 -0.070 0.011 5.1E-10 40.3 BMI Women rs11677607 T C 0.246 -0.115 0.013 2.9E-19 79.0 BMI Women rs1457457 A T 0.532 0.068 0.011 3.8E-10 38.1 BMI Women rs6739199 T C 0.270 0.076 0.012 3.2E-10 40.4 BMI Women rs1984559 A G 0.808 0.078 0.014 3.3E-08 29.5 BMI Women rs13002158 A G 0.813 -0.100 0.014 1.2E-12 51.4 BMI Women rs12692596 T C 0.361 0.070 0.011 9.7E-11 40.3 BMI Women rs12692738 T C 0.764 -0.078 0.012 2.8E-10 38.8 BMI Women rs7588437 A G 0.367 -0.085 0.011 8.4E-15 58.6 BMI Women rs7594237 A T 0.277 -0.069 0.012 1.8E-08 32.7 BMI Women rs4482463 A C 0.917 -0.175 0.020 5.2E-18 75.5 BMI Women rs11692326 T C 0.230 0.075 0.012 2.0E-09 36.0 BMI Women rs4673553 T G 0.555 -0.074 0.011 2.6E-11 44.3 BMI Women rs12612009 T G 0.663 -0.068 0.012 3.8E-09 34.5 BMI Women rs6720868 T C 0.306 0.081 0.012 4.6E-12 49.6 BMI Women rs1801282 C G 0.897 -0.087 0.016 4.7E-08 30.4 BMI Women rs2470520 T C 0.577 -0.061 0.011 4.2E-08 30.0 BMI Women rs4858223 T C 0.326 -0.077 0.012 8.3E-11 41.5 BMI Women rs13062093 T G 0.632 -0.066 0.012 8.0E-09 32.6 BMI Women rs1799923 A G 0.111 -0.117 0.017 5.1E-12 48.2 ### Page 25 BMI Women rs2681781 A G 0.480 -0.110 0.011 1.6E-25 107.4 BMI Women rs1916801 A T 0.620 0.082 0.011 1.8E-14 59.7 BMI Women rs1452075 T C 0.732 0.076 0.012 1.5E-10 40.4 BMI Women rs925018 C G 0.665 -0.068 0.011 9.8E-10 38.1 BMI Women rs7647242 T C 0.394 0.070 0.011 3.9E-10 39.7 BMI Women rs13068138 T C 0.192 0.111 0.013 3.6E-17 73.2 BMI Women rs1949197 A G 0.401 0.067 0.011 3.0E-09 36.5 BMI Women rs1492014 T C 0.568 -0.070 0.011 2.8E-10 39.7 BMI Women rs1436348 A G 0.432 -0.064 0.011 6.3E-09 33.9 BMI Women rs1289736 T C 0.543 0.067 0.011 1.4E-09 36.5 BMI Women rs17619973 A G 0.936 0.116 0.021 1.3E-08 31.7 BMI Women rs7428670 C G 0.269 0.097 0.012 3.1E-15 60.4 BMI Women rs7621025 T C 0.261 -0.096 0.012 1.6E-15 64.0 BMI Women rs16851483 T G 0.073 0.174 0.022 2.3E-15 62.3 BMI Women rs355754 T C 0.604 -0.068 0.011 4.3E-10 38.1 BMI Women rs247975 T C 0.466 -0.087 0.011 3.6E-15 62.6 BMI Women rs10513801 T G 0.878 0.169 0.015 1.3E-27 121.0 BMI Women rs4677812 A C 0.293 -0.069 0.012 9.4E-09 33.2 BMI Women rs1477887 A G 0.441 -0.075 0.011 1.7E-11 46.0 BMI Women rs9291467 T C 0.465 0.072 0.011 5.7E-11 42.5 BMI Women rs6448587 A C 0.802 0.081 0.014 1.6E-08 31.4 BMI Women rs337637 A G 0.358 -0.060 0.011 3.0E-08 29.5 BMI Women rs10938397 A G 0.571 -0.151 0.011 1.7E-45 205.0 BMI Women rs2271046 A T 0.694 -0.066 0.012 2.4E-08 30.0 BMI Women rs2192158 A G 0.449 0.070 0.011 2.1E-10 40.3 BMI Women rs11945861 A G 0.247 -0.072 0.013 3.1E-08 30.9 BMI Women rs10002111 A G 0.224 0.081 0.013 9.3E-10 36.4 BMI Women rs4148155 A G 0.887 0.098 0.017 6.2E-09 33.6 BMI Women rs12645001 A G 0.356 -0.068 0.012 4.1E-09 34.5 BMI Women rs13107325 T C 0.083 0.217 0.021 9.3E-25 105.5 BMI Women rs4834272 T C 0.687 -0.069 0.011 8.2E-10 38.7 BMI Women rs1403846 T C 0.833 0.078 0.014 1.6E-08 31.2 BMI Women rs4864201 T C 0.346 0.063 0.011 6.3E-09 32.4 BMI Women rs10000502 T G 0.367 -0.073 0.012 1.8E-10 39.6 BMI Women rs750090 T C 0.624 0.075 0.012 7.4E-11 42.3 BMI Women rs13110266 A G 0.403 -0.068 0.011 1.5E-10 41.7 BMI Women rs1491333 T G 0.263 -0.071 0.012 9.9E-09 32.0 BMI Women rs6890310 A G 0.294 -0.074 0.012 1.4E-09 37.9 BMI Women rs782971 A G 0.754 -0.083 0.012 4.9E-12 47.3 BMI Women rs10471636 A G 0.525 -0.082 0.012 4.7E-13 50.2 BMI Women rs2112347 T G 0.630 0.149 0.011 2.1E-42 180.5 BMI Women rs6870983 T C 0.206 -0.102 0.012 9.6E-16 66.5 BMI Women rs2161228 T C 0.101 0.135 0.018 5.5E-14 57.7 BMI Women rs10473922 A G 0.458 0.064 0.011 7.0E-09 33.4 BMI Women rs6885199 A G 0.036 0.187 0.031 8.5E-10 37.1 BMI Women rs2161097 T C 0.442 0.062 0.011 2.3E-08 31.5 BMI Women rs158186 A G 0.166 -0.138 0.015 3.2E-20 85.7 BMI Women rs4895231 C G 0.468 0.069 0.011 9.3E-10 38.7 ### Page 26 BMI Women rs13174863 A G 0.854 -0.130 0.015 4.5E-18 75.9 BMI Women rs4569924 T C 0.435 0.076 0.011 7.4E-13 51.6 BMI Women rs6556810 T C 0.534 -0.060 0.011 5.0E-08 29.1 BMI Women rs2053682 A C 0.678 0.088 0.012 1.9E-13 53.6 BMI Women rs2228213 A G 0.337 -0.071 0.011 9.2E-11 41.4 BMI Women rs11757278 T C 0.695 0.065 0.012 4.8E-08 29.6 BMI Women rs3806114 A G 0.694 -0.068 0.012 4.5E-09 34.5 BMI Women rs2178899 A T 0.885 0.119 0.016 7.2E-14 56.5 BMI Women rs11751591 A G 0.153 -0.089 0.015 1.2E-08 33.4 BMI Women rs2814992 A G 0.667 -0.138 0.011 1.2E-35 155.7 BMI Women rs1579557 T C 0.288 0.102 0.012 3.1E-17 71.9 BMI Women rs943005 T C 0.147 0.191 0.014 2.0E-43 188.4 BMI Women rs2465043 A G 0.351 -0.068 0.012 3.2E-09 35.0 BMI Women rs209416 A T 0.324 0.080 0.012 8.7E-12 47.8 BMI Women rs13209872 C G 0.345 -0.068 0.012 6.1E-09 35.0 BMI Women rs12202969 A G 0.479 -0.070 0.011 1.9E-10 39.7 BMI Women rs1417665 T C 0.802 0.096 0.014 5.7E-12 47.1 BMI Women rs768023 A G 0.603 0.089 0.011 1.4E-16 70.7 BMI Women rs2357760 A G 0.673 0.076 0.011 1.1E-11 47.8 BMI Women rs11754747 T C 0.271 0.070 0.012 1.3E-08 31.5 BMI Women rs198665 A C 0.394 0.064 0.011 4.4E-09 33.9 BMI Women rs2185027 A C 0.698 -0.074 0.012 1.1E-10 41.2 BMI Women rs9478496 T C 0.847 -0.082 0.015 4.6E-08 30.1 BMI Women rs13213408 A T 0.847 0.095 0.016 4.3E-09 35.6 BMI Women rs11765458 T C 0.781 0.076 0.014 4.1E-08 29.7 BMI Women rs836525 T C 0.173 0.085 0.015 9.8E-09 32.2 BMI Women rs4307239 A G 0.536 -0.068 0.011 1.3E-09 37.6 BMI Women rs11971098 A G 0.909 -0.114 0.020 6.5E-09 33.4 BMI Women rs10499694 A G 0.494 0.065 0.011 4.0E-10 38.2 BMI Women rs10237317 A G 0.588 -0.066 0.011 6.8E-10 39.3 BMI Women rs2267812 A C 0.807 -0.083 0.014 1.7E-09 35.2 BMI Women rs1167800 A G 0.553 0.096 0.011 3.7E-19 82.6 BMI Women rs7805441 T C 0.547 0.070 0.011 2.0E-10 40.3 BMI Women rs2528531 A C 0.651 -0.070 0.012 1.3E-09 36.5 BMI Women rs13240600 A G 0.835 0.083 0.014 9.7E-09 33.3 BMI Women rs2299383 T C 0.395 0.087 0.011 2.7E-16 68.4 BMI Women rs7788008 A G 0.430 -0.082 0.011 1.1E-13 55.3 BMI Women rs2045293 T C 0.417 0.091 0.011 4.1E-16 67.5 BMI Women rs2289705 A G 0.796 -0.072 0.012 1.5E-08 33.3 BMI Women rs2968864 T C 0.756 0.078 0.013 9.3E-10 36.4 BMI Women rs4240673 T C 0.456 0.085 0.011 1.0E-15 64.0 BMI Women rs2959592 T C 0.809 0.082 0.013 6.3E-10 36.9 BMI Women rs1362910 A G 0.413 0.064 0.011 3.0E-09 33.9 BMI Women rs4320543 A G 0.419 -0.062 0.011 2.9E-08 31.5 BMI Women rs12681792 A C 0.204 0.088 0.014 2.6E-10 39.8 BMI Women rs1431659 A G 0.274 0.094 0.012 2.9E-14 56.8 BMI Women rs17405819 T C 0.683 0.105 0.012 7.8E-20 82.5 BMI Women rs12680842 A G 0.684 0.062 0.012 3.4E-08 29.3 ### Page 27 BMI Women rs2721965 A C 0.669 0.089 0.012 2.1E-14 60.1 BMI Women rs10099330 A G 0.538 -0.063 0.011 9.9E-09 32.4 BMI Women rs10124645 A G 0.592 0.065 0.011 5.0E-09 35.0 BMI Women rs10756714 A G 0.555 0.100 0.011 1.5E-19 81.8 BMI Women rs10962550 C G 0.174 0.092 0.014 1.7E-10 41.0 BMI Women rs16912921 A C 0.313 0.120 0.011 1.6E-26 117.2 BMI Women rs973345 T C 0.611 0.068 0.011 1.1E-09 38.1 BMI Women rs563132 A T 0.605 0.087 0.012 2.0E-14 56.3 BMI Women rs10797115 T C 0.532 0.077 0.011 4.1E-12 48.4 BMI Women rs10992867 A G 0.269 0.089 0.012 8.9E-13 50.6 BMI Women rs10118701 A G 0.672 -0.085 0.012 2.2E-13 53.8 BMI Women rs7024334 T G 0.226 0.076 0.012 1.6E-09 37.4 BMI Women rs1928295 T C 0.571 0.077 0.011 2.8E-13 52.9 BMI Women rs3829849 T C 0.350 0.065 0.011 1.9E-09 35.0 BMI Women rs10733682 A G 0.458 0.076 0.011 1.9E-12 51.6 BMI Women rs2267958 A G 0.510 -0.077 0.012 1.9E-11 45.0 BMI Women rs1009473 T C 0.526 -0.061 0.011 3.4E-08 30.5 BMI Women rs7084454 A G 0.306 0.108 0.012 7.4E-20 81.0 BMI Women rs12762034 T C 0.928 -0.123 0.021 2.3E-09 35.2 BMI Women rs1624134 C G 0.392 0.062 0.011 3.5E-08 31.0 BMI Women rs10823897 A T 0.416 0.071 0.011 2.1E-10 40.8 BMI Women rs10761785 T G 0.514 -0.083 0.011 4.2E-15 61.1 BMI Women rs10824347 A T 0.771 0.085 0.013 5.5E-11 42.5 BMI Women rs7899106 A G 0.950 -0.180 0.024 7.6E-14 56.3 BMI Women rs563296 A G 0.558 0.084 0.012 8.8E-14 53.2 BMI Women rs3977755 T C 0.287 -0.069 0.012 8.5E-09 32.7 BMI Women rs6585198 A G 0.444 -0.074 0.011 1.2E-12 49.0 BMI Women rs1681743 T C 0.401 -0.063 0.012 3.7E-08 29.8 BMI Women rs1561589 A G 0.361 0.076 0.011 4.2E-12 47.2 BMI Women rs4880341 T C 0.572 -0.069 0.011 4.5E-10 38.7 BMI Women rs7395632 T C 0.357 -0.062 0.012 3.9E-08 29.3 BMI Women rs4929923 T C 0.337 -0.106 0.011 2.5E-22 92.3 BMI Women rs11022762 T C 0.368 -0.074 0.012 5.6E-11 41.2 BMI Women rs6265 T C 0.183 -0.177 0.013 8.0E-40 172.7 BMI Women rs2862961 A G 0.699 -0.115 0.012 5.3E-22 91.4 BMI Women rs10742752 T C 0.375 -0.063 0.011 4.0E-09 36.0 BMI Women rs7124681 A C 0.418 0.119 0.011 9.3E-29 126.1 BMI Women rs893006 A C 0.721 0.083 0.012 4.0E-13 52.0 BMI Women rs7102454 T C 0.643 -0.080 0.012 5.1E-12 47.8 BMI Women rs2605603 A G 0.481 -0.063 0.011 1.4E-09 36.0 BMI Women rs7105462 A G 0.581 0.069 0.011 4.4E-10 39.2 BMI Women rs1048932 A C 0.440 -0.087 0.011 2.5E-16 68.4 BMI Women rs1003081 T C 0.435 0.069 0.011 6.3E-11 42.8 BMI Women rs4459316 T C 0.551 -0.074 0.011 2.3E-11 44.8 BMI Women rs4936175 T C 0.559 -0.076 0.011 6.7E-12 47.2 BMI Women rs329651 T G 0.805 0.087 0.013 2.0E-10 41.8 BMI Women rs12364470 T G 0.855 -0.096 0.014 2.5E-11 44.4 BMI Women rs11611246 T G 0.199 0.102 0.013 1.3E-14 61.7 ### Page 28 BMI Women rs7976757 T C 0.177 -0.092 0.014 2.9E-10 41.0 BMI Women rs16926318 A G 0.921 -0.109 0.020 4.2E-08 30.7 BMI Women rs16926778 C G 0.077 0.125 0.021 1.4E-09 36.6 BMI Women rs7138803 A G 0.388 0.140 0.011 9.7E-38 160.1 BMI Women rs2271189 A G 0.396 -0.070 0.012 6.4E-10 37.0 BMI Women rs11173522 A C 0.233 0.081 0.013 9.0E-10 36.4 BMI Women rs645026 A G 0.744 -0.077 0.012 4.8E-10 37.9 BMI Women rs2279574 A C 0.549 -0.079 0.011 2.0E-12 51.5 BMI Women rs2712643 A C 0.239 -0.074 0.012 1.5E-09 37.9 BMI Women rs17033633 T C 0.169 -0.100 0.014 7.3E-12 48.5 BMI Women rs6606686 C G 0.698 -0.086 0.011 2.5E-14 59.9 BMI Women rs1466852 A G 0.227 0.078 0.013 3.6E-09 33.9 BMI Women rs6489156 T C 0.734 0.107 0.012 1.0E-17 72.9 BMI Women rs7133378 A G 0.334 0.076 0.012 1.9E-11 43.3 BMI Women rs1967772 A G 0.271 -0.079 0.012 1.1E-10 40.3 BMI Women rs1045411 T C 0.283 -0.067 0.012 2.6E-08 30.9 BMI Women rs4942925 T C 0.574 0.062 0.011 2.8E-09 34.9 BMI Women rs12429545 A G 0.120 0.140 0.016 1.1E-18 77.8 BMI Women rs6561937 A T 0.767 -0.095 0.013 6.0E-13 53.2 BMI Women rs9538162 T C 0.579 0.069 0.011 6.3E-10 38.7 BMI Women rs9571687 A C 0.342 -0.070 0.012 3.2E-09 36.5 BMI Women rs1441264 A G 0.583 0.082 0.011 5.2E-14 55.3 BMI Women rs9531786 C G 0.371 -0.066 0.012 8.4E-09 33.1 BMI Women rs4343164 T C 0.276 0.072 0.012 4.0E-09 33.3 BMI Women rs1927790 T C 0.608 -0.065 0.011 1.3E-09 37.7 BMI Women rs4586287 C G 0.674 0.066 0.012 2.9E-08 30.5 BMI Women rs7335249 T C 0.558 0.065 0.011 4.9E-09 34.5 BMI Women rs2479958 A G 0.486 0.065 0.012 1.4E-08 31.6 BMI Women rs2754079 A G 0.571 -0.075 0.011 2.3E-11 46.0 BMI Women rs1569979 A G 0.774 0.111 0.013 1.6E-17 72.6 BMI Women rs17522122 T G 0.467 0.080 0.011 6.5E-14 57.6 BMI Women rs2806034 T G 0.668 0.066 0.011 5.3E-09 35.5 BMI Women rs7141420 T C 0.549 0.101 0.011 7.8E-22 91.1 BMI Women rs1285997 C G 0.288 -0.072 0.012 3.2E-09 36.0 BMI Women rs9989141 T C 0.616 0.081 0.011 3.2E-13 53.4 BMI Women rs3803286 A G 0.341 0.083 0.012 8.3E-13 51.4 BMI Women rs709400 A G 0.621 0.088 0.011 4.4E-16 64.0 BMI Women rs12101625 C G 0.614 0.066 0.012 5.5E-09 33.1 BMI Women rs8038522 T G 0.413 -0.067 0.011 1.3E-09 37.1 BMI Women rs6493498 T C 0.446 0.078 0.011 1.5E-13 54.9 BMI Women rs8024806 T C 0.937 0.131 0.023 9.8E-09 33.5 BMI Women rs8033510 T C 0.364 0.066 0.012 1.1E-08 32.6 BMI Women rs4776982 A G 0.769 0.149 0.012 4.2E-33 143.1 BMI Women rs12914489 A G 0.081 0.109 0.017 1.6E-10 39.8 BMI Women rs12593036 A G 0.690 0.074 0.012 6.6E-10 37.9 BMI Women rs11073383 A G 0.480 -0.076 0.011 3.3E-12 47.8 BMI Women rs214249 T G 0.607 0.080 0.012 1.4E-12 48.4 BMI Women rs12448257 A G 0.219 0.072 0.013 3.1E-08 30.9 ### Page 29 BMI Women rs879620 T C 0.596 0.119 0.011 5.4E-26 115.3 BMI Women rs9926784 T C 0.800 0.121 0.013 6.0E-20 81.0 BMI Women rs17767765 T C 0.515 -0.061 0.011 2.6E-08 30.5 BMI Women rs7498665 A G 0.619 -0.127 0.011 1.9E-32 144.0 BMI Women rs2289292 T C 0.332 -0.091 0.012 1.1E-14 57.8 BMI Women rs4889606 A G 0.631 0.129 0.011 1.3E-32 135.8 BMI Women rs1558902 A T 0.409 0.337 0.011 1.1E-215 1018.2 BMI Women rs4783718 T C 0.419 0.098 0.011 1.8E-19 78.7 BMI Women rs811054 T C 0.533 0.078 0.011 3.2E-13 54.2 BMI Women rs2012502 A C 0.384 0.074 0.011 3.0E-11 44.3 BMI Women rs4790292 A C 0.147 -0.126 0.016 1.7E-15 63.5 BMI Women rs3826408 T C 0.418 0.058 0.011 4.5E-08 30.3 BMI Women rs1075901 T C 0.452 -0.069 0.011 4.4E-11 42.8 BMI Women rs4986044 T C 0.453 -0.083 0.011 2.2E-15 61.8 BMI Women rs12150665 T C 0.592 0.080 0.011 5.9E-14 57.6 BMI Women rs9906944 T C 0.355 -0.091 0.012 7.3E-15 62.7 BMI Women rs7211966 T C 0.029 -0.226 0.038 4.9E-09 34.5 BMI Women rs8075273 A C 0.290 -0.077 0.012 5.6E-11 44.4 BMI Women rs2619976 T C 0.399 0.070 0.012 6.2E-10 37.0 BMI Women rs12949279 T C 0.563 0.086 0.011 6.1E-16 66.2 BMI Women rs4969387 C G 0.738 -0.074 0.013 6.9E-09 32.5 BMI Women rs9955276 T C 0.144 0.107 0.015 8.0E-12 48.1 BMI Women rs1808579 T C 0.481 -0.095 0.011 9.4E-20 81.0 BMI Women rs16975921 A T 0.695 -0.078 0.012 3.9E-11 42.5 BMI Women rs1518159 T C 0.250 -0.091 0.012 6.7E-13 52.8 BMI Women rs7239114 A G 0.542 0.075 0.011 3.9E-12 49.6 BMI Women rs6567160 T C 0.751 -0.273 0.012 8.7E-108 475.6 BMI Women rs17066856 T C 0.891 0.191 0.018 1.4E-27 115.7 BMI Women rs12981256 A G 0.527 0.087 0.011 3.9E-15 62.6 BMI Women rs895330 C G 0.807 0.087 0.014 6.6E-10 39.0 BMI Women rs273504 A G 0.576 -0.073 0.011 1.3E-10 43.1 BMI Women rs17724992 A G 0.719 0.082 0.012 6.7E-12 46.2 BMI Women rs11880870 A G 0.519 0.095 0.011 3.3E-18 73.4 BMI Women rs17751061 T C 0.159 -0.087 0.015 1.3E-08 32.0 BMI Women rs12462975 A G 0.325 0.098 0.012 2.6E-16 65.9 BMI Women rs11667280 C G 0.797 0.076 0.014 3.1E-08 29.7 BMI Women rs7250833 T C 0.311 0.072 0.012 7.2E-10 38.5 BMI Women rs185350 T C 0.490 0.062 0.011 7.1E-09 33.9 BMI Women rs11672660 T C 0.187 -0.154 0.013 5.9E-31 131.4 BMI Women rs9304665 A T 0.740 0.098 0.013 1.8E-14 57.1 BMI Women rs1884389 T C 0.440 -0.067 0.011 1.2E-09 37.1 BMI Women rs1884897 A G 0.375 -0.081 0.011 9.1E-14 54.0 BMI Women rs1409818 T C 0.108 0.121 0.018 1.6E-11 46.4 BMI Women rs6050446 A G 0.032 -0.179 0.031 6.2E-09 33.8 BMI Women rs6142096 A G 0.520 0.064 0.011 4.2E-09 33.9 BMI Women rs16989232 A G 0.385 0.062 0.011 1.5E-08 31.0 BMI Women rs17806224 A G 0.181 -0.139 0.014 3.5E-22 92.8 BMI Women rs6010784 T C 0.508 0.061 0.011 1.1E-08 32.8 ### Page 30 BMI Women rs2836754 T C 0.369 -0.072 0.011 3.7E-11 45.9 BMI Women rs8126575 T G 0.868 0.088 0.016 3.0E-08 31.1 BMI Women rs427943 A C 0.428 -0.085 0.011 1.4E-14 59.2 BMI Women rs4820408 T G 0.375 0.065 0.011 1.4E-09 38.2 BMI Women rs13055841 A G 0.693 0.066 0.012 3.7E-08 30.5 BMI Women rs13053342 A G 0.400 0.074 0.012 1.3E-10 40.6 BMI Men rs2803316 A G 0.457 -0.072 0.012 4.0E-09 35.5 BMI Men rs3762444 T C 0.461 -0.093 0.012 1.5E-14 60.2 BMI Men rs11121210 T C 0.342 -0.072 0.012 7.9E-09 32.8 BMI Men rs11581010 A G 0.763 -0.086 0.014 1.0E-09 37.7 BMI Men rs2235549 T G 0.840 -0.102 0.016 8.3E-11 41.7 BMI Men rs2271928 A G 0.375 -0.065 0.012 9.9E-09 32.1 BMI Men rs12061406 T C 0.078 -0.131 0.022 1.7E-09 36.8 BMI Men rs1768808 T C 0.624 0.069 0.012 3.5E-08 30.3 BMI Men rs977747 T G 0.439 0.076 0.012 1.3E-11 43.9 BMI Men rs7531656 A G 0.330 0.095 0.012 2.3E-15 62.7 BMI Men rs2481665 T C 0.583 0.090 0.012 2.0E-15 60.7 BMI Men rs2310754 A G 0.510 0.075 0.012 4.4E-10 38.4 BMI Men rs1993709 A G 0.178 -0.199 0.014 1.5E-42 189.5 BMI Men rs12566985 A G 0.558 -0.087 0.011 1.1E-14 61.9 BMI Men rs12049202 T C 0.186 0.109 0.015 5.5E-13 53.1 BMI Men rs12034762 T C 0.392 0.081 0.012 4.8E-11 41.8 BMI Men rs11165643 T C 0.579 0.097 0.012 1.7E-17 70.1 BMI Men rs17024393 T C 0.968 -0.342 0.034 1.7E-23 100.3 BMI Men rs6587552 A G 0.241 0.086 0.014 1.0E-09 37.7 BMI Men rs543874 A G 0.775 -0.173 0.014 3.7E-35 154.1 BMI Men rs10920678 A G 0.422 0.064 0.012 1.9E-08 30.7 BMI Men rs2172935 T C 0.321 0.128 0.012 3.6E-24 105.5 BMI Men rs823094 T G 0.553 0.071 0.012 3.8E-10 38.0 BMI Men rs4653942 A G 0.209 -0.077 0.014 4.4E-08 30.4 BMI Men rs2125231 T C 0.323 0.082 0.012 5.5E-11 43.3 BMI Men rs4639527 A G 0.704 -0.096 0.013 2.0E-13 54.9 BMI Men rs12714415 T C 0.850 0.290 0.015 1.1E-80 356.3 BMI Men rs2693826 A G 0.429 -0.079 0.012 5.0E-11 43.0 BMI Men rs10182181 A G 0.505 -0.131 0.011 5.5E-32 140.9 BMI Men rs1260326 T C 0.392 -0.088 0.012 2.1E-14 58.1 BMI Men rs2888172 A G 0.547 -0.068 0.012 1.4E-08 31.8 BMI Men rs10185199 A G 0.287 -0.076 0.014 3.8E-08 30.1 BMI Men rs7561278 T C 0.764 0.084 0.015 1.1E-08 31.9 BMI Men rs12986742 T C 0.517 -0.095 0.012 3.2E-15 62.1 BMI Men rs887912 T C 0.299 0.110 0.012 2.7E-19 77.6 BMI Men rs11685481 T C 0.850 0.095 0.016 9.0E-09 33.6 BMI Men rs4581940 T C 0.586 0.075 0.012 8.4E-10 38.4 BMI Men rs7557796 T C 0.361 0.075 0.012 2.2E-09 35.5 BMI Men rs1437377 T G 0.854 -0.117 0.017 1.5E-11 45.9 BMI Men rs10197031 T C 0.729 -0.081 0.013 7.7E-10 38.7 BMI Men rs902695 A G 0.492 -0.072 0.012 2.3E-09 35.5 BMI Men rs11687120 A G 0.446 0.066 0.012 4.7E-08 30.0 ### Page 31 BMI Men rs961360 A G 0.890 0.102 0.016 3.8E-10 39.2 BMI Men rs453520 T C 0.566 -0.077 0.012 1.2E-10 41.5 BMI Men rs908671 C G 0.709 0.077 0.013 5.8E-09 33.1 BMI Men rs1019612 T C 0.664 0.086 0.012 1.4E-11 47.4 BMI Men rs10497807 C G 0.502 -0.070 0.011 5.0E-10 40.3 BMI Men rs7569376 T C 0.207 0.094 0.014 1.3E-10 42.3 BMI Men rs17203016 A G 0.802 -0.082 0.014 9.9E-09 32.1 BMI Men rs7599312 A G 0.275 -0.105 0.012 1.5E-16 70.3 BMI Men rs1541777 A G 0.551 -0.075 0.011 1.8E-11 46.0 BMI Men rs7600417 A G 0.853 0.100 0.017 2.9E-09 35.3 BMI Men rs11692572 C G 0.596 -0.067 0.012 3.7E-08 30.9 BMI Men rs2596902 A G 0.650 -0.072 0.012 1.3E-08 33.3 BMI Men rs6804842 A G 0.430 -0.087 0.012 1.3E-14 57.5 BMI Men rs762318 A C 0.628 0.074 0.012 2.1E-09 34.6 BMI Men rs1524887 T C 0.419 -0.067 0.012 3.6E-08 30.9 BMI Men rs6803741 T C 0.664 -0.072 0.013 2.0E-08 30.9 BMI Men rs2188151 T G 0.415 0.137 0.012 2.7E-29 129.0 BMI Men rs6787805 A G 0.139 -0.099 0.017 2.3E-09 34.6 BMI Men rs2365389 T C 0.395 -0.085 0.012 5.3E-14 54.4 BMI Men rs11915371 A C 0.804 -0.105 0.015 1.1E-12 49.5 BMI Men rs13078509 T C 0.028 0.231 0.040 8.4E-09 32.8 BMI Men rs3849570 A C 0.354 0.072 0.012 2.6E-09 35.5 BMI Men rs12495178 T C 0.641 0.109 0.012 1.5E-20 88.7 BMI Men rs7628689 A G 0.169 -0.110 0.016 1.4E-11 45.4 BMI Men rs1492014 T C 0.568 -0.102 0.012 1.6E-17 72.6 BMI Men rs1436351 T G 0.737 0.086 0.013 3.4E-11 43.5 BMI Men rs6768228 A G 0.632 -0.072 0.012 6.8E-09 32.8 BMI Men rs2918217 T C 0.153 0.106 0.017 7.2E-10 37.7 BMI Men rs1320903 A G 0.309 0.123 0.013 1.7E-21 89.2 BMI Men rs645040 T G 0.770 0.090 0.013 3.2E-11 44.6 BMI Men rs2035935 A G 0.924 -0.160 0.022 4.0E-13 52.4 BMI Men rs355777 C G 0.397 0.082 0.012 1.8E-11 46.2 BMI Men rs9870575 A G 0.141 -0.114 0.017 1.5E-11 45.9 BMI Men rs5398 A G 0.283 0.081 0.012 5.5E-11 41.8 BMI Men rs2606227 T C 0.368 0.068 0.012 4.6E-08 29.8 BMI Men rs9816226 A T 0.174 -0.164 0.015 5.1E-29 121.0 BMI Men rs6841761 T G 0.521 -0.064 0.011 9.0E-09 33.9 BMI Men rs2242189 T C 0.633 0.082 0.012 5.6E-11 42.8 BMI Men rs13130484 T C 0.431 0.169 0.012 6.4E-50 215.1 BMI Men rs2237025 T C 0.430 0.068 0.012 3.1E-08 31.8 BMI Men rs13107325 T C 0.085 0.238 0.023 3.2E-26 110.9 BMI Men rs2613726 A G 0.370 -0.078 0.012 4.3E-10 38.8 BMI Men rs2391518 T C 0.315 0.076 0.012 1.7E-10 40.4 BMI Men rs1296328 A C 0.443 0.096 0.012 2.1E-15 64.0 BMI Men rs6537285 A G 0.280 -0.086 0.013 1.2E-10 40.4 BMI Men rs6827083 A G 0.579 -0.073 0.012 1.3E-10 40.1 BMI Men rs828544 T G 0.435 0.066 0.012 4.5E-08 30.0 BMI Men rs1503526 T C 0.530 -0.067 0.012 5.7E-09 34.0 ### Page 32 BMI Men rs253414 T C 0.657 0.125 0.012 1.1E-24 107.3 BMI Men rs4532349 A G 0.783 0.078 0.013 6.6E-09 33.5 BMI Men rs7733438 T G 0.859 -0.166 0.017 2.1E-21 91.8 BMI Men rs6235 C G 0.734 -0.100 0.013 1.9E-13 54.7 BMI Men rs11951673 T C 0.395 -0.090 0.012 7.8E-15 60.7 BMI Men rs289228 C G 0.836 0.107 0.016 9.8E-12 45.3 BMI Men rs7711753 A G 0.416 -0.063 0.012 2.6E-08 30.3 BMI Men rs7715256 T G 0.563 -0.078 0.012 4.5E-12 46.1 BMI Men rs7730898 A G 0.731 0.081 0.012 9.9E-11 42.3 BMI Men rs6556301 T G 0.370 -0.069 0.012 1.6E-08 32.7 BMI Men rs2228213 A G 0.337 -0.073 0.012 6.8E-10 36.5 BMI Men rs9366639 C G 0.804 0.093 0.016 3.8E-09 34.6 BMI Men rs2178899 A T 0.886 0.118 0.017 5.4E-12 46.7 BMI Men rs14398 A G 0.661 -0.107 0.017 7.1E-10 38.0 BMI Men rs2744974 T C 0.322 0.110 0.012 8.5E-20 83.9 BMI Men rs17681686 C G 0.295 0.101 0.013 5.3E-15 60.5 BMI Men rs1358980 T C 0.472 -0.075 0.012 6.1E-11 42.8 BMI Men rs2206277 T C 0.151 0.218 0.015 5.4E-50 214.5 BMI Men rs1327259 A G 0.610 0.076 0.012 6.0E-10 37.4 BMI Men rs7773045 T G 0.922 0.127 0.021 1.6E-09 36.0 BMI Men rs12663742 A G 0.372 -0.087 0.012 1.7E-12 48.5 BMI Men rs10872224 T G 0.585 0.097 0.012 3.8E-15 59.8 BMI Men rs17789218 T C 0.753 -0.073 0.013 3.3E-08 29.5 BMI Men rs768023 A G 0.602 0.064 0.012 3.0E-08 30.7 BMI Men rs1159974 T C 0.492 -0.067 0.012 2.0E-08 30.9 BMI Men rs6569648 T C 0.765 -0.073 0.013 3.7E-08 29.5 BMI Men rs765875 T C 0.466 -0.066 0.012 3.4E-08 30.5 BMI Men rs13191362 A G 0.853 0.127 0.017 2.3E-13 54.2 BMI Men rs9364687 T G 0.398 -0.067 0.012 4.0E-09 34.0 BMI Men rs9638713 A G 0.027 0.216 0.036 2.3E-09 36.0 BMI Men rs215635 T C 0.622 -0.088 0.012 1.2E-12 49.5 BMI Men rs7779853 A G 0.461 -0.063 0.012 2.8E-08 29.8 BMI Men rs10269783 A G 0.423 0.083 0.012 7.6E-13 51.4 BMI Men rs1167827 A G 0.439 -0.104 0.012 2.9E-19 81.8 BMI Men rs2245368 T C 0.810 -0.158 0.016 4.4E-23 98.8 BMI Men rs1965529 A G 0.771 0.084 0.015 4.2E-08 29.9 BMI Men rs1701829 A G 0.336 0.103 0.012 6.8E-16 67.7 BMI Men rs13228237 C G 0.213 -0.079 0.014 4.6E-08 29.9 BMI Men rs4841504 A C 0.502 -0.093 0.012 4.2E-16 64.7 BMI Men rs4123853 T C 0.373 0.080 0.012 1.1E-10 40.8 BMI Men rs4258002 T G 0.141 -0.089 0.016 2.0E-08 31.4 BMI Men rs7827210 A G 0.397 0.086 0.012 2.3E-12 47.4 BMI Men rs7012923 A C 0.441 0.078 0.012 4.9E-11 42.5 BMI Men rs2017657 T G 0.559 -0.074 0.012 7.0E-10 37.9 BMI Men rs2588785 A G 0.284 -0.101 0.012 1.7E-15 65.9 BMI Men rs957447 A C 0.239 -0.108 0.014 8.6E-14 56.3 BMI Men rs800571 T C 0.246 -0.087 0.014 6.9E-10 39.0 BMI Men rs11781699 T C 0.811 -0.085 0.014 6.7E-09 34.4 ### Page 33 BMI Men rs7826388 T C 0.037 -0.180 0.032 1.4E-08 32.1 BMI Men rs4740619 T C 0.542 0.090 0.011 1.5E-15 66.1 BMI Men rs10738451 T C 0.715 -0.078 0.013 2.2E-09 36.4 BMI Men rs10968114 A C 0.534 0.074 0.012 8.7E-10 37.5 BMI Men rs1412235 C G 0.314 0.112 0.012 9.9E-21 87.6 BMI Men rs10746862 T G 0.580 -0.075 0.012 8.6E-10 38.4 BMI Men rs1187351 A C 0.399 -0.067 0.012 4.5E-08 30.9 BMI Men rs6559921 A T 0.771 0.087 0.014 1.2E-09 36.4 BMI Men rs6477694 T C 0.642 -0.067 0.012 8.9E-09 34.0 BMI Men rs7038943 T C 0.659 0.073 0.012 6.5E-09 34.2 BMI Men rs10760279 T G 0.383 0.074 0.013 7.5E-09 32.5 BMI Men rs3902840 A G 0.087 0.148 0.021 2.5E-12 48.7 BMI Men rs4740383 A G 0.418 0.074 0.012 2.7E-09 35.1 BMI Men rs11251291 A C 0.467 -0.068 0.012 1.7E-08 31.8 BMI Men rs10828247 A G 0.664 -0.081 0.012 1.7E-10 42.3 BMI Men rs3758438 T C 0.078 0.132 0.023 7.3E-09 34.0 BMI Men rs7072873 T C 0.535 -0.071 0.012 5.5E-09 34.6 BMI Men rs10788494 C G 0.483 0.075 0.012 5.4E-10 38.4 BMI Men rs17094222 T C 0.791 -0.123 0.014 1.1E-18 77.3 BMI Men rs284851 C G 0.879 -0.119 0.017 2.8E-12 50.2 BMI Men rs7903146 T C 0.278 -0.111 0.012 3.6E-19 78.9 BMI Men rs845084 A G 0.269 0.075 0.014 3.8E-08 29.3 BMI Men rs7113874 T C 0.327 -0.069 0.012 3.3E-09 36.0 BMI Men rs900144 T C 0.584 0.074 0.012 5.5E-10 37.9 BMI Men rs6265 T C 0.183 -0.230 0.014 6.3E-58 253.9 BMI Men rs1765139 T C 0.767 0.106 0.014 1.8E-13 54.3 BMI Men rs2862996 T G 0.704 -0.096 0.012 2.5E-15 63.4 BMI Men rs7124681 A C 0.419 0.132 0.012 5.1E-31 131.3 BMI Men rs7102454 T C 0.642 -0.085 0.012 1.3E-11 46.3 BMI Men rs349088 A C 0.473 -0.072 0.012 2.0E-09 36.0 BMI Men rs647248 A G 0.544 0.077 0.012 2.6E-10 41.5 BMI Men rs12286929 A G 0.507 -0.086 0.011 2.3E-14 59.9 BMI Men rs7944782 T G 0.504 -0.070 0.012 7.5E-09 34.1 BMI Men rs10894670 A C 0.561 -0.068 0.012 1.6E-09 35.0 BMI Men rs11611246 T G 0.196 0.118 0.014 8.0E-17 67.2 BMI Men rs10772983 T C 0.544 -0.067 0.011 2.0E-09 37.1 BMI Men rs10842240 C G 0.125 0.124 0.018 4.6E-12 48.6 BMI Men rs11170468 A C 0.784 0.077 0.013 7.8E-09 33.1 BMI Men rs11181001 A G 0.482 0.069 0.012 1.2E-09 36.0 BMI Men rs7132908 A G 0.392 0.166 0.013 1.3E-38 164.2 BMI Men rs705704 A G 0.322 -0.078 0.012 1.5E-10 39.3 BMI Men rs1689437 A G 0.948 -0.143 0.024 2.0E-09 36.7 BMI Men rs7488867 T C 0.257 -0.106 0.014 5.7E-14 57.6 BMI Men rs10850184 T G 0.321 0.080 0.013 3.5E-10 38.3 BMI Men rs12369179 T C 0.084 -0.169 0.022 1.4E-14 58.2 BMI Men rs7323 C G 0.267 -0.084 0.013 4.1E-10 39.1 BMI Men rs2504236 T C 0.586 -0.073 0.012 1.9E-09 36.5 BMI Men rs9595893 T G 0.360 -0.096 0.012 1.2E-14 58.6 ### Page 34 BMI Men rs9603697 T C 0.317 0.095 0.013 1.3E-13 53.2 BMI Men rs12429545 A G 0.121 0.162 0.017 2.0E-21 92.2 BMI Men rs7338127 A T 0.330 0.095 0.013 1.4E-13 53.2 BMI Men rs1441264 A G 0.582 0.087 0.012 1.4E-13 56.9 BMI Men rs912690 C G 0.557 -0.083 0.012 6.9E-12 47.9 BMI Men rs9168 A C 0.273 -0.072 0.013 4.6E-08 30.9 BMI Men rs12868881 A T 0.405 0.087 0.012 1.1E-12 51.8 BMI Men rs10132280 A C 0.313 -0.144 0.012 1.4E-31 132.3 BMI Men rs1950709 A G 0.556 -0.065 0.011 7.3E-09 35.0 BMI Men rs1955540 T C 0.194 -0.096 0.015 2.9E-10 39.1 BMI Men rs4900714 T G 0.473 0.096 0.012 1.2E-15 64.0 BMI Men rs217671 A G 0.726 -0.081 0.013 2.2E-09 36.4 BMI Men rs3902951 T G 0.771 -0.073 0.013 4.4E-08 29.1 BMI Men rs17109256 A G 0.237 0.148 0.013 2.8E-27 121.0 BMI Men rs12888545 A G 0.745 -0.084 0.014 2.0E-09 36.4 BMI Men rs2148564 A G 0.285 -0.095 0.013 1.1E-12 50.0 BMI Men rs7161194 A G 0.345 0.103 0.013 3.3E-15 63.4 BMI Men rs2015407 A G 0.353 0.087 0.012 2.7E-12 47.9 BMI Men rs11636536 T C 0.497 0.071 0.012 2.8E-09 35.0 BMI Men rs10851458 A G 0.581 0.071 0.012 6.0E-09 35.0 BMI Men rs4776970 A T 0.643 0.134 0.012 1.5E-30 135.1 BMI Men rs4777541 T C 0.784 0.101 0.014 1.1E-12 49.0 BMI Men rs8024572 A G 0.611 0.075 0.012 7.8E-10 38.9 BMI Men rs8036171 A C 0.374 0.074 0.012 4.3E-10 37.5 BMI Men rs12448257 A G 0.219 0.089 0.014 1.2E-10 41.1 BMI Men rs879620 T C 0.597 0.100 0.012 3.1E-16 64.6 BMI Men rs9926784 T C 0.801 0.108 0.014 5.7E-14 55.8 BMI Men rs9921854 A G 0.087 -0.140 0.022 1.9E-10 40.3 BMI Men rs3888190 A C 0.380 0.151 0.012 7.0E-40 172.3 BMI Men rs7201780 T C 0.454 -0.107 0.012 1.4E-18 79.6 BMI Men rs1558902 A T 0.415 0.392 0.012 1.2E-257 1153.2 BMI Men rs889398 T C 0.418 -0.100 0.012 1.5E-18 75.8 BMI Men rs756717 A G 0.394 -0.068 0.012 8.6E-09 34.5 BMI Men rs7206608 C G 0.674 -0.072 0.013 1.9E-08 30.9 BMI Men rs3923783 A C 0.178 -0.109 0.016 7.5E-12 46.9 BMI Men rs12450045 A G 0.458 0.069 0.012 1.7E-08 32.7 BMI Men rs4986044 T C 0.454 -0.087 0.012 1.5E-14 56.9 BMI Men rs8065172 A G 0.238 -0.080 0.014 1.2E-08 33.2 BMI Men rs12150665 T C 0.593 0.087 0.012 3.4E-14 56.9 BMI Men rs676387 A C 0.303 0.078 0.013 4.1E-09 36.0 BMI Men rs208015 T C 0.070 0.175 0.024 8.7E-14 55.5 BMI Men rs12939549 A G 0.556 0.096 0.011 1.3E-17 75.6 BMI Men rs7226371 A G 0.844 -0.089 0.015 7.7E-09 33.8 BMI Men rs891387 T C 0.496 0.109 0.012 6.8E-20 82.4 BMI Men rs11874191 T C 0.728 -0.081 0.014 3.1E-09 34.0 BMI Men rs2612575 A G 0.276 -0.077 0.013 1.5E-08 32.7 BMI Men rs9951619 T G 0.222 -0.089 0.013 1.7E-11 44.1 BMI Men rs6567160 T C 0.749 -0.256 0.013 2.1E-82 362.4 ### Page 35 BMI Men rs17066856 T C 0.890 0.145 0.019 2.7E-14 59.6 BMI Men rs17710386 T C 0.664 -0.079 0.012 3.7E-11 43.0 BMI Men rs1787267 C G 0.063 -0.157 0.025 2.5E-10 39.5 BMI Men rs7258309 T G 0.784 0.112 0.015 6.5E-14 56.5 BMI Men rs273512 T C 0.410 0.079 0.012 1.7E-10 39.8 BMI Men rs9636202 A G 0.281 -0.085 0.013 5.5E-11 43.0 BMI Men rs7258722 A T 0.411 -0.096 0.012 8.6E-15 58.6 BMI Men rs17513613 T C 0.695 -0.086 0.012 1.5E-12 51.3 BMI Men rs11084553 A G 0.849 0.114 0.017 9.4E-12 45.9 BMI Men rs769449 A G 0.102 -0.116 0.019 1.6E-09 36.6 BMI Men rs1800437 C G 0.186 -0.175 0.014 1.7E-33 148.0 BMI Men rs9304665 A T 0.741 0.132 0.014 4.8E-21 89.3 BMI Men rs7249149 A G 0.696 0.073 0.013 4.4E-08 29.5 BMI Men rs2145270 T C 0.616 0.100 0.012 7.0E-18 75.1 BMI Men rs8123881 A G 0.864 -0.092 0.016 2.5E-08 31.9 BMI Men rs7272093 A G 0.700 -0.083 0.013 1.1E-09 37.7 BMI Men rs742760 A T 0.820 0.112 0.015 7.1E-13 53.0 BMI Men rs6092143 T C 0.368 0.072 0.012 1.1E-08 32.8 BMI Men rs13047416 C G 0.628 0.075 0.012 9.8E-10 36.5 BMI Men rs427943 A C 0.427 -0.084 0.012 2.2E-12 49.0 BMI Men rs138383 T C 0.514 -0.075 0.012 1.4E-09 35.5 BMI Men rs733381 A G 0.767 0.099 0.014 5.2E-13 50.5 HbA1c Overall rs11191561 G C 0.150 0.122 0.022 2.3E-08 31.3 HbA1c Overall rs11195508 G C 0.149 -0.119 0.022 4.3E-08 30.0 HbA1c Overall rs114322470 G T 0.019 -0.363 0.057 2.2E-10 40.3 HbA1c Overall rs34872471 C T 0.291 0.485 0.017 3.5E-177 806.4 HbA1c Overall rs10736269 C T 0.471 -0.098 0.016 4.5E-10 38.9 HbA1c Overall rs11257655 T C 0.208 0.245 0.019 1.5E-37 164.1 HbA1c Overall rs7904973 T G 0.576 0.093 0.016 3.0E-09 35.2 HbA1c Overall rs11598987 G C 0.527 0.088 0.016 1.8E-08 31.7 HbA1c Overall rs3847378 G A 0.264 -0.116 0.018 5.3E-11 43.1 HbA1c Overall rs61850681 A G 0.239 -0.227 0.018 3.2E-35 153.4 HbA1c Overall rs561279660 T C 0.015 -0.690 0.068 3.7E-24 102.8 HbA1c Overall rs72814244 G C 0.052 0.330 0.035 3.5E-21 89.2 HbA1c Overall rs150025254 T C 0.030 -1.049 0.046 4.5E-114 515.7 HbA1c Overall rs75048187 G A 0.013 0.610 0.070 3.6E-18 75.6 HbA1c Overall rs6480398 G A 0.906 1.273 0.027 0.0E+00 2171.4 HbA1c Overall rs555721560 G T 0.022 0.310 0.056 2.5E-08 31.1 HbA1c Overall rs138691176 A G 0.033 0.267 0.045 4.0E-09 34.6 HbA1c Overall rs1248673 C T 0.293 0.125 0.017 2.3E-13 53.7 HbA1c Overall rs701848 C T 0.390 -0.121 0.016 3.3E-14 57.5 HbA1c Overall rs7923837 A G 0.380 -0.196 0.016 1.7E-34 150.0 HbA1c Overall rs2068888 A G 0.449 -0.116 0.016 1.2E-13 55.0 HbA1c Overall rs12365580 A G 0.151 -0.218 0.022 1.3E-23 100.3 HbA1c Overall rs11042852 G A 0.087 0.269 0.028 3.1E-22 94.0 HbA1c Overall rs3802885 C A 0.075 -0.206 0.030 3.0E-12 48.7 HbA1c Overall rs6589939 G A 0.379 0.112 0.016 2.9E-12 48.7 HbA1c Overall rs11512059 T C 0.083 0.184 0.028 6.5E-11 42.7 ### Page 36 HbA1c Overall rs7124355 G A 0.675 -0.125 0.017 5.0E-14 56.7 HbA1c Overall rs689 T A 0.710 -0.148 0.017 9.1E-18 73.7 HbA1c Overall rs12419995 T A 0.656 -0.205 0.017 7.2E-33 142.6 HbA1c Overall rs2237895 C A 0.415 0.185 0.016 5.3E-32 138.7 HbA1c Overall rs10047488 C G 0.083 0.177 0.029 6.4E-10 38.2 HbA1c Overall rs4755309 T G 0.114 -0.171 0.024 2.9E-12 48.8 HbA1c Overall rs10501320 C G 0.264 -0.182 0.018 4.9E-25 106.8 HbA1c Overall rs174549 A G 0.310 -0.167 0.017 2.1E-23 99.4 HbA1c Overall rs12294913 G C 0.050 0.281 0.037 3.9E-14 57.2 HbA1c Overall rs1152620 G A 0.262 0.120 0.018 1.1E-11 46.2 HbA1c Overall rs11602873 T A 0.157 -0.236 0.021 1.2E-28 123.4 HbA1c Overall rs689419 G T 0.782 0.114 0.019 1.6E-09 36.4 HbA1c Overall rs10830963 G C 0.275 0.435 0.017 7.8E-139 629.7 HbA1c Overall rs3020069 A G 0.683 0.106 0.017 1.7E-10 40.8 HbA1c Overall rs4910498 T A 0.643 -0.224 0.016 2.4E-43 190.6 HbA1c Overall rs7310615 G C 0.517 0.193 0.016 5.9E-35 152.2 HbA1c Overall rs2936839 C T 0.610 -0.105 0.016 4.9E-11 43.2 HbA1c Overall rs73226260 A G 0.034 -0.286 0.043 3.2E-11 44.1 HbA1c Overall rs11043299 C T 0.621 0.104 0.017 1.5E-09 36.6 HbA1c Overall rs7306544 C T 0.104 0.146 0.025 9.6E-09 32.9 HbA1c Overall rs704168 G A 0.184 -0.123 0.020 9.7E-10 37.4 HbA1c Overall rs10492373 A G 0.196 -0.177 0.019 1.3E-19 82.1 HbA1c Overall rs4238013 T C 0.796 -0.122 0.019 3.6E-10 39.3 HbA1c Overall rs76895963 G T 0.020 -1.275 0.060 2.1E-101 457.4 HbA1c Overall rs12819124 A C 0.472 -0.417 0.016 2.3E-158 719.7 HbA1c Overall rs6580661 T A 0.224 0.227 0.019 7.3E-34 147.2 HbA1c Overall rs11169605 C T 0.358 0.125 0.016 1.3E-14 59.3 HbA1c Overall rs765634 G A 0.367 -0.090 0.016 3.5E-08 30.4 HbA1c Overall rs79755767 A G 0.100 -0.243 0.026 1.2E-20 86.7 HbA1c Overall rs4760278 A C 0.226 -0.128 0.019 4.1E-12 48.1 HbA1c Overall rs2258238 T A 0.105 0.218 0.025 8.2E-18 73.9 HbA1c Overall rs2137537 C T 0.546 0.090 0.016 1.0E-08 32.8 HbA1c Overall rs12813389 T A 0.539 0.091 0.016 5.5E-09 34.0 HbA1c Overall rs79621919 A G 0.059 -0.261 0.033 2.9E-15 62.3 HbA1c Overall rs1044364 C T 0.056 -0.191 0.034 2.0E-08 31.5 HbA1c Overall rs12876143 C T 0.089 0.554 0.027 1.3E-91 412.4 HbA1c Overall rs368865 G A 0.725 0.189 0.017 1.1E-27 119.0 HbA1c Overall rs7329468 T C 0.217 -0.256 0.019 1.9E-41 181.9 HbA1c Overall rs4769580 A T 0.219 0.224 0.019 1.9E-32 140.6 HbA1c Overall rs75629141 A T 0.829 -0.209 0.021 5.8E-24 101.9 HbA1c Overall rs1327315 T C 0.289 -0.134 0.017 5.7E-15 61.0 HbA1c Overall rs61990662 T C 0.173 -0.127 0.021 9.5E-10 37.4 HbA1c Overall rs9324022 C T 0.206 0.163 0.020 6.4E-17 69.9 HbA1c Overall rs12147688 T G 0.258 0.145 0.018 4.5E-16 66.0 HbA1c Overall rs8013143 G A 0.278 0.139 0.017 1.3E-15 64.0 HbA1c Overall rs7151822 C T 0.247 -0.164 0.018 9.6E-20 82.7 HbA1c Overall rs72681698 C T 0.011 -0.497 0.074 2.3E-11 44.7 HbA1c Overall rs11621337 A C 0.063 -0.206 0.035 3.2E-09 35.0 ### Page 37 HbA1c Overall rs2285005 A G 0.340 0.182 0.016 1.5E-28 122.8 HbA1c Overall rs35889227 T G 0.631 -0.150 0.016 9.5E-21 87.3 HbA1c Overall rs34715063 C T 0.130 0.145 0.023 4.1E-10 39.1 HbA1c Overall rs28526689 A G 0.344 0.101 0.016 6.3E-10 38.2 HbA1c Overall rs4516170 C T 0.050 -0.325 0.036 6.6E-20 83.4 HbA1c Overall rs1550026 T A 0.408 0.145 0.016 6.4E-20 83.5 HbA1c Overall rs59153558 G A 0.720 0.200 0.017 1.0E-30 132.8 HbA1c Overall rs11638511 G A 0.561 0.091 0.016 5.9E-09 33.9 HbA1c Overall rs7166540 G A 0.238 -0.127 0.018 5.0E-12 47.7 HbA1c Overall rs1866476 C T 0.732 -0.141 0.018 7.9E-16 64.9 HbA1c Overall rs61215894 C T 0.558 -0.096 0.016 2.0E-09 36.0 HbA1c Overall rs4451969 C T 0.671 -0.139 0.017 3.6E-17 71.0 HbA1c Overall rs35591 G C 0.233 0.136 0.018 1.1E-13 55.3 HbA1c Overall rs112414002 T C 0.026 0.281 0.049 1.0E-08 32.8 HbA1c Overall rs181207 T C 0.336 0.164 0.016 2.5E-23 99.1 HbA1c Overall rs2858010 C T 0.340 -0.169 0.016 1.1E-24 105.2 HbA1c Overall rs4889490 T G 0.390 -0.108 0.016 1.0E-11 46.2 HbA1c Overall rs8050500 C T 0.446 -0.180 0.016 1.1E-30 132.6 HbA1c Overall rs1121980 A G 0.422 0.146 0.016 1.6E-20 86.3 HbA1c Overall rs35158985 G A 0.308 0.159 0.017 2.9E-21 89.6 HbA1c Overall rs72802365 C G 0.079 -0.193 0.029 2.3E-11 44.7 HbA1c Overall rs247826 T C 0.223 0.185 0.019 4.6E-23 97.8 HbA1c Overall rs72811487 A G 0.035 -0.386 0.042 4.3E-20 84.3 HbA1c Overall rs7195055 T C 0.015 -0.392 0.065 1.8E-09 36.1 HbA1c Overall rs551118 G C 0.578 0.382 0.016 9.0E-127 574.1 HbA1c Overall rs11655029 C T 0.695 -0.223 0.017 1.0E-39 174.0 HbA1c Overall rs12943904 C G 0.306 -0.097 0.017 7.6E-09 33.4 HbA1c Overall rs4985997 T C 0.350 -0.136 0.016 7.0E-17 69.7 HbA1c Overall rs216195 G T 0.303 0.137 0.017 4.8E-16 65.9 HbA1c Overall rs12450826 T A 0.293 -0.186 0.017 1.7E-26 113.5 HbA1c Overall rs9894558 A T 0.270 -0.115 0.018 4.2E-10 39.0 HbA1c Overall rs10908278 A T 0.515 -0.123 0.016 3.5E-15 62.0 HbA1c Overall rs150325706 A T 0.262 0.131 0.019 1.1E-11 46.2 HbA1c Overall rs7222851 C T 0.512 -0.105 0.016 1.4E-11 45.7 HbA1c Overall rs35895680 A C 0.327 -0.096 0.017 9.1E-09 33.0 HbA1c Overall rs12600858 A G 0.224 -0.203 0.019 1.4E-27 118.4 HbA1c Overall rs72838857 G A 0.213 0.144 0.019 3.4E-14 57.5 HbA1c Overall rs2854215 T C 0.280 -0.113 0.018 1.4E-10 41.2 HbA1c Overall rs1030097 G C 0.495 0.106 0.016 1.2E-11 45.9 HbA1c Overall rs1641523 T C 0.567 -0.186 0.016 3.0E-32 139.8 HbA1c Overall rs2748427 G A 0.218 0.540 0.019 2.9E-182 829.8 HbA1c Overall rs7208422 T A 0.475 0.117 0.015 3.5E-14 57.4 HbA1c Overall rs113373052 T C 0.313 0.467 0.017 3.5E-171 778.8 HbA1c Overall rs4791641 T C 0.505 -0.148 0.016 1.3E-21 91.2 HbA1c Overall rs8088001 G T 0.071 -0.168 0.030 2.8E-08 30.9 HbA1c Overall rs12607898 G A 0.747 0.164 0.018 3.9E-20 84.5 HbA1c Overall rs12605978 T C 0.322 0.093 0.017 2.5E-08 31.1 HbA1c Overall rs3810027 G C 0.335 0.096 0.016 5.9E-09 33.9 ### Page 38 HbA1c Overall rs2658747 G A 0.379 0.110 0.016 7.0E-12 47.0 HbA1c Overall rs11671760 A G 0.206 0.117 0.019 1.6E-09 36.4 HbA1c Overall rs56397034 C G 0.391 -0.156 0.016 8.0E-23 96.7 HbA1c Overall rs4808579 C T 0.392 0.315 0.016 2.0E-87 393.1 HbA1c Overall rs4808072 C T 0.581 0.101 0.016 1.6E-10 40.9 HbA1c Overall rs75372982 G A 0.289 -0.195 0.017 2.7E-29 126.3 HbA1c Overall rs72973028 C A 0.172 0.135 0.021 7.0E-11 42.5 HbA1c Overall rs17561351 G A 0.064 0.210 0.032 3.8E-11 43.7 HbA1c Overall rs10407429 A G 0.426 -0.167 0.016 1.7E-26 113.5 HbA1c Overall rs62136856 G A 0.717 0.127 0.017 1.8E-13 54.2 HbA1c Overall rs12459419 T C 0.326 -0.172 0.017 2.1E-25 108.5 HbA1c Overall rs2278832 G A 0.205 0.120 0.020 2.0E-09 36.0 HbA1c Overall rs45607834 T C 0.103 0.154 0.026 2.0E-09 36.0 HbA1c Overall rs351978 G A 0.581 -0.103 0.016 1.1E-10 41.7 HbA1c Overall rs11166447 C T 0.359 -0.101 0.016 5.2E-10 38.6 HbA1c Overall rs76757826 C T 0.055 0.206 0.034 1.6E-09 36.4 HbA1c Overall rs1975283 C A 0.685 -0.166 0.017 4.1E-23 98.1 HbA1c Overall rs2487569 T A 0.111 0.152 0.025 1.2E-09 36.9 HbA1c Overall rs198325 T C 0.222 -0.184 0.019 5.6E-23 97.4 HbA1c Overall rs12748814 T C 0.085 0.174 0.028 3.5E-10 39.4 HbA1c Overall rs857725 G T 0.267 0.543 0.017 1.9E-211 964.4 HbA1c Overall rs7528296 C T 0.386 -0.112 0.016 2.7E-12 48.9 HbA1c Overall rs523647 T C 0.463 0.099 0.017 3.0E-09 35.2 HbA1c Overall rs2808454 T A 0.542 0.145 0.016 1.8E-20 86.1 HbA1c Overall rs1078308 C A 0.727 -0.124 0.017 1.4E-12 50.2 HbA1c Overall rs340882 G C 0.621 0.239 0.016 5.7E-50 221.0 HbA1c Overall rs348330 A G 0.635 -0.147 0.016 1.1E-19 82.4 HbA1c Overall rs3811444 T C 0.334 0.166 0.016 5.7E-24 101.9 HbA1c Overall rs28695210 A G 0.083 0.267 0.029 1.5E-20 86.4 HbA1c Overall rs563437995 C G 0.008 -1.076 0.092 8.8E-32 137.7 HbA1c Overall rs797399 G A 0.729 -0.097 0.018 4.0E-08 30.2 HbA1c Overall rs1175550 G A 0.230 -0.285 0.019 1.6E-52 232.7 HbA1c Overall rs3768321 T G 0.197 0.169 0.020 4.3E-18 75.2 HbA1c Overall rs557458132 T C 0.282 -0.137 0.017 3.7E-15 61.9 HbA1c Overall rs72900998 C T 0.089 -0.250 0.027 3.3E-20 84.8 HbA1c Overall rs4926930 G A 0.426 -0.089 0.016 1.4E-08 32.2 HbA1c Overall rs7513688 A G 0.361 0.126 0.016 6.1E-15 60.9 HbA1c Overall rs1166698 A G 0.212 -0.122 0.019 1.2E-10 41.5 HbA1c Overall rs13042195 G A 0.213 -0.108 0.019 1.6E-08 32.0 HbA1c Overall rs149142833 T C 0.156 0.172 0.022 1.7E-15 63.3 HbA1c Overall rs4431018 G A 0.379 0.088 0.016 4.3E-08 30.0 HbA1c Overall rs67897819 A G 0.212 0.129 0.020 5.0E-11 43.2 HbA1c Overall rs55966194 G C 0.284 -0.149 0.017 6.0E-18 74.5 HbA1c Overall rs6014993 G A 0.487 0.176 0.016 1.6E-29 127.3 HbA1c Overall rs4809556 A G 0.596 -0.106 0.016 2.3E-11 44.7 HbA1c Overall rs1056441 C T 0.673 0.099 0.017 2.0E-09 35.9 HbA1c Overall rs6077396 A G 0.507 -0.142 0.016 7.9E-20 83.1 HbA1c Overall rs3827181 T C 0.346 0.127 0.016 6.2E-15 60.8 ### Page 39 HbA1c Overall rs61138219 T C 0.153 -0.155 0.022 7.6E-13 51.4 HbA1c Overall rs17850433 C T 0.012 0.633 0.071 6.4E-19 79.0 HbA1c Overall rs35963032 T C 0.152 -0.140 0.022 1.4E-10 41.1 HbA1c Overall rs12628032 T C 0.305 0.103 0.017 8.1E-10 37.7 HbA1c Overall rs6518681 G A 0.907 0.220 0.027 2.5E-16 67.2 HbA1c Overall rs117721418 T C 0.081 -0.226 0.028 1.9E-15 63.1 HbA1c Overall rs855791 G A 0.561 -0.422 0.016 4.1E-159 723.2 HbA1c Overall rs2143918 C A 0.471 -0.186 0.016 5.3E-33 143.3 HbA1c Overall rs2009581 A G 0.275 0.096 0.017 4.5E-08 29.9 HbA1c Overall rs650588 G A 0.581 -0.106 0.016 1.7E-11 45.3 HbA1c Overall rs111631066 A G 0.015 -0.479 0.065 1.6E-13 54.5 HbA1c Overall rs4667575 G C 0.592 0.088 0.016 2.6E-08 31.0 HbA1c Overall rs3843328 A G 0.711 -0.161 0.017 1.2E-20 86.9 HbA1c Overall rs853787 T G 0.651 0.636 0.016 0.0E+00 1517.2 HbA1c Overall rs4972439 C T 0.220 -0.193 0.019 8.9E-25 105.7 HbA1c Overall rs6731171 A T 0.626 0.104 0.016 1.9E-10 40.5 HbA1c Overall rs6736362 T C 0.562 0.114 0.016 4.3E-13 52.5 HbA1c Overall rs1399627 G A 0.653 0.153 0.016 6.3E-21 88.1 HbA1c Overall rs838717 A G 0.566 0.114 0.016 3.0E-13 53.2 HbA1c Overall rs72781680 T C 0.135 0.348 0.023 1.2E-52 233.2 HbA1c Overall rs13020237 G A 0.182 -0.114 0.020 1.2E-08 32.5 HbA1c Overall rs780093 C T 0.618 0.177 0.016 1.4E-28 123.0 HbA1c Overall rs11124556 T G 0.514 -0.090 0.016 6.7E-09 33.6 HbA1c Overall rs77981966 T C 0.076 -0.490 0.029 6.3E-63 280.5 HbA1c Overall rs2164701 C G 0.140 0.199 0.022 7.1E-19 78.8 HbA1c Overall rs78583604 T G 0.132 0.180 0.024 2.6E-14 58.0 HbA1c Overall rs7606173 C G 0.431 -0.164 0.016 1.2E-25 109.6 HbA1c Overall rs7572278 A T 0.204 0.194 0.019 8.2E-24 101.2 HbA1c Overall rs4435501 C A 0.108 0.141 0.026 4.3E-08 30.0 HbA1c Overall rs9826367 G A 0.449 -0.251 0.016 2.7E-58 259.2 HbA1c Overall rs11708067 G A 0.245 -0.353 0.018 1.6E-85 384.3 HbA1c Overall rs12497133 A G 0.533 0.120 0.016 2.1E-14 58.4 HbA1c Overall rs13059110 T G 0.133 0.144 0.023 3.6E-10 39.3 HbA1c Overall rs75367758 A G 0.048 -0.296 0.036 3.2E-16 66.7 HbA1c Overall rs12493136 A G 0.164 0.169 0.021 1.0E-15 64.4 HbA1c Overall rs11926854 C T 0.037 -0.240 0.042 7.9E-09 33.3 HbA1c Overall rs6785881 T C 0.481 -0.140 0.016 2.2E-19 81.1 HbA1c Overall rs4955744 C A 0.146 0.134 0.022 1.0E-09 37.3 HbA1c Overall rs1905505 A G 0.284 -0.283 0.017 1.2E-60 270.0 HbA1c Overall rs360408 A T 0.565 -0.124 0.016 9.1E-15 60.1 HbA1c Overall rs4894797 A G 0.576 0.188 0.016 4.5E-33 143.6 HbA1c Overall rs4859137 T C 0.772 0.117 0.019 3.4E-10 39.4 HbA1c Overall rs73061095 G T 0.314 0.147 0.017 1.3E-18 77.6 HbA1c Overall rs6777684 G A 0.610 0.175 0.016 7.2E-28 119.8 HbA1c Overall rs41297495 T C 0.382 -0.099 0.016 4.9E-10 38.7 HbA1c Overall rs2015708 T C 0.137 0.167 0.023 1.5E-13 54.5 HbA1c Overall rs2686588 G C 0.565 -0.135 0.016 6.0E-18 74.5 HbA1c Overall rs1496653 G A 0.204 -0.138 0.019 6.8E-13 51.6 ### Page 40 HbA1c Overall rs4678917 C T 0.105 -0.146 0.026 1.3E-08 32.4 HbA1c Overall rs62246446 G C 0.176 -0.138 0.020 1.3E-11 45.9 HbA1c Overall rs2230929 A G 0.171 0.258 0.021 8.8E-36 156.0 HbA1c Overall rs2336664 G A 0.363 0.097 0.016 2.0E-09 36.0 HbA1c Overall rs11130982 G T 0.711 0.110 0.017 1.6E-10 40.9 HbA1c Overall rs9840088 C A 0.201 -0.113 0.020 7.9E-09 33.3 HbA1c Overall rs397834892 G A 0.471 -0.105 0.016 1.6E-11 45.4 HbA1c Overall rs17508261 C T 0.122 0.188 0.024 2.5E-15 62.6 HbA1c Overall rs9994509 G A 0.393 -0.135 0.016 2.8E-17 71.5 HbA1c Overall rs2044341 C T 0.684 -0.356 0.017 5.9E-100 450.7 HbA1c Overall rs76505278 C T 0.103 -0.187 0.026 2.7E-13 53.5 HbA1c Overall rs13125518 G A 0.459 -0.090 0.016 1.1E-08 32.7 HbA1c Overall rs75636043 A G 0.078 -0.172 0.029 3.9E-09 34.7 HbA1c Overall rs6840504 T C 0.443 0.113 0.016 4.9E-13 52.3 HbA1c Overall rs55881843 A G 0.139 -0.226 0.023 1.5E-23 100.0 HbA1c Overall rs34811474 A G 0.232 -0.107 0.018 5.0E-09 34.2 HbA1c Overall rs6844176 C T 0.455 0.087 0.016 2.8E-08 30.9 HbA1c Overall rs9990955 T C 0.284 0.126 0.017 2.1E-13 53.9 HbA1c Overall rs4689394 G C 0.599 0.121 0.016 2.9E-14 57.8 HbA1c Overall rs1481012 G A 0.113 0.198 0.025 6.9E-16 65.2 HbA1c Overall rs35188965 T C 0.582 0.120 0.016 2.6E-14 58.0 HbA1c Overall rs469753 T G 0.475 0.091 0.016 5.3E-09 34.1 HbA1c Overall rs10053046 G A 0.329 0.118 0.017 1.5E-12 50.1 HbA1c Overall rs6885132 G C 0.099 -0.233 0.026 8.5E-19 78.4 HbA1c Overall rs35018839 G A 0.095 -0.151 0.027 1.9E-08 31.6 HbA1c Overall rs13167071 C G 0.640 0.135 0.016 5.9E-17 70.0 HbA1c Overall rs7720275 C T 0.170 0.161 0.021 6.2E-15 60.8 HbA1c Overall rs56395926 A G 0.229 -0.108 0.019 5.2E-09 34.1 HbA1c Overall rs3857286 T C 0.695 -0.104 0.017 9.4E-10 37.5 HbA1c Overall rs6893283 T C 0.015 -0.377 0.065 6.0E-09 33.8 HbA1c Overall rs145381182 A G 0.090 0.157 0.027 1.0E-08 32.8 HbA1c Overall rs2270927 G C 0.094 0.193 0.027 4.1E-13 52.6 HbA1c Overall rs6878122 A G 0.680 -0.181 0.017 1.5E-27 118.3 HbA1c Overall rs17419291 C T 0.087 -0.165 0.028 1.9E-09 36.1 HbA1c Overall rs2546197 G T 0.078 0.160 0.029 3.6E-08 30.3 HbA1c Overall rs144489757 G C 0.284 -0.120 0.017 3.0E-12 48.7 HbA1c Overall rs148570357 T C 0.295 -0.155 0.017 1.6E-19 81.7 HbA1c Overall rs72939920 T A 0.235 -0.194 0.018 4.6E-26 111.5 HbA1c Overall rs9398642 T C 0.145 -0.132 0.022 2.2E-09 35.8 HbA1c Overall rs1490384 T C 0.498 0.122 0.016 4.8E-15 61.3 HbA1c Overall rs9402645 T G 0.200 0.119 0.020 1.1E-09 37.1 HbA1c Overall rs9376091 T C 0.262 -0.288 0.018 4.3E-59 262.9 HbA1c Overall rs592423 C A 0.554 -0.131 0.016 3.6E-17 71.0 HbA1c Overall rs3910736 T C 0.308 0.110 0.017 7.1E-11 42.5 HbA1c Overall rs262813 C T 0.478 0.090 0.016 8.0E-09 33.3 HbA1c Overall rs2665357 C A 0.517 0.120 0.016 1.5E-14 59.2 HbA1c Overall rs67131976 T C 0.172 0.315 0.021 3.2E-53 235.9 HbA1c Overall rs142513102 G A 0.026 -0.484 0.049 1.9E-23 99.6 ### Page 41 HbA1c Overall rs1800562 A G 0.079 -0.842 0.029 6.8E-188 855.8 HbA1c Overall rs2442725 C T 0.694 0.159 0.017 4.3E-21 88.8 HbA1c Overall rs9268469 A G 0.155 0.301 0.021 1.2E-44 196.5 HbA1c Overall rs833058 T C 0.365 0.111 0.016 5.2E-12 47.6 HbA1c Overall rs998584 A C 0.482 0.156 0.016 1.2E-23 100.6 HbA1c Overall rs2294856 C G 0.355 0.114 0.016 1.9E-12 49.6 HbA1c Overall rs3748059 G A 0.799 -0.149 0.019 1.6E-14 58.9 HbA1c Overall rs13192435 C T 0.025 0.353 0.049 8.5E-13 51.2 HbA1c Overall rs78588343 A G 0.179 -0.226 0.020 8.3E-29 124.0 HbA1c Overall rs1171105 C T 0.695 0.095 0.017 4.1E-08 30.1 HbA1c Overall rs12667932 A G 0.080 -0.314 0.029 5.5E-28 120.3 HbA1c Overall rs35722851 C T 0.495 -0.088 0.016 1.5E-08 32.1 HbA1c Overall rs8176059 A G 0.011 -0.439 0.073 2.2E-09 35.8 HbA1c Overall rs17168486 T C 0.173 0.198 0.021 7.4E-22 92.3 HbA1c Overall rs10487796 A T 0.450 -0.183 0.016 9.0E-32 137.6 HbA1c Overall rs6459737 A G 0.347 -0.117 0.016 6.4E-13 51.7 HbA1c Overall rs60238952 G A 0.219 -0.113 0.019 2.3E-09 35.7 HbA1c Overall rs1708302 T C 0.501 -0.178 0.016 1.4E-30 132.2 HbA1c Overall rs76323047 G A 0.118 0.335 0.024 5.4E-44 193.6 HbA1c Overall rs1004558 T C 0.179 0.727 0.020 4.1E-283 1295.3 HbA1c Overall rs836472 A G 0.266 -0.109 0.018 4.7E-10 38.8 HbA1c Overall rs2460421 T A 0.502 -0.112 0.015 5.8E-13 51.9 HbA1c Overall rs6953344 G A 0.246 0.127 0.018 2.2E-12 49.3 HbA1c Overall rs3211821 G A 0.562 -0.106 0.016 1.7E-11 45.3 HbA1c Overall rs6973494 A C 0.516 0.116 0.016 1.4E-13 54.7 HbA1c Overall rs10488532 T C 0.108 -0.143 0.025 1.1E-08 32.6 HbA1c Overall rs117370443 C T 0.039 0.373 0.040 1.4E-20 86.6 HbA1c Overall rs636089 C T 0.386 0.095 0.016 2.9E-09 35.3 HbA1c Overall rs7820334 T C 0.311 -0.146 0.017 4.8E-18 75.0 HbA1c Overall rs2737263 T G 0.284 -0.156 0.017 1.1E-19 82.4 HbA1c Overall rs13266634 T C 0.311 -0.379 0.017 2.4E-113 512.3 HbA1c Overall rs58253018 T A 0.635 0.105 0.017 2.3E-10 40.2 HbA1c Overall rs2060985 G A 0.537 -0.122 0.016 4.8E-15 61.3 HbA1c Overall rs3757971 C T 0.380 0.130 0.016 3.2E-16 66.7 HbA1c Overall rs187055391 A G 0.172 -0.134 0.021 1.5E-10 41.0 HbA1c Overall rs66593272 T A 0.038 -0.915 0.041 2.4E-111 503.0 HbA1c Overall rs4737010 A G 0.228 0.534 0.019 1.0E-182 831.9 HbA1c Overall rs55840085 A G 0.355 0.169 0.016 1.7E-25 108.9 HbA1c Overall rs28708563 A G 0.042 0.220 0.039 2.3E-08 31.3 HbA1c Overall rs62523081 A G 0.362 0.094 0.016 7.1E-09 33.5 HbA1c Overall rs1967604 G A 0.712 -0.208 0.017 1.1E-33 146.3 HbA1c Overall rs1560980 C G 0.041 0.316 0.039 5.1E-16 65.8 HbA1c Overall rs584048 T C 0.861 0.134 0.022 2.1E-09 35.9 HbA1c Overall rs5900831 G T 0.653 0.135 0.017 3.2E-16 66.7 HbA1c Overall rs550057 T C 0.255 0.325 0.018 5.9E-74 331.1 HbA1c Overall rs28641468 C T 0.756 0.234 0.018 1.9E-38 168.2 HbA1c Overall rs10811660 A G 0.173 -0.359 0.020 1.5E-68 306.3 HbA1c Overall rs10758593 A G 0.397 0.107 0.016 1.1E-11 46.1 ### Page 42 HbA1c Overall rs2236496 C T 0.208 -0.182 0.019 2.5E-21 89.9 HbA1c Overall rs11145347 C T 0.197 0.239 0.020 1.7E-34 150.1 HbA1c Overall rs61750929 T C 0.055 -0.692 0.034 8.6E-92 413.1 HbA1c Overall rs7047279 C T 0.568 -0.124 0.016 4.2E-15 61.6 HbA1c Women rs7903146 T C 0.290 0.423 0.023 5.3E-76 340.7 HbA1c Women rs11257655 T C 0.208 0.234 0.026 7.3E-20 83.2 HbA1c Women rs7923442 G A 0.178 -0.156 0.027 9.8E-09 32.9 HbA1c Women rs61850681 A G 0.239 -0.218 0.025 5.9E-19 79.1 HbA1c Women rs10998678 A G 0.053 0.341 0.047 2.6E-13 53.5 HbA1c Women rs2015803 T C 0.247 0.318 0.024 1.4E-39 173.3 HbA1c Women rs17476364 C T 0.110 -2.079 0.033 0.0E+00 3990.7 HbA1c Women rs2305196 A G 0.265 -0.221 0.024 1.1E-20 86.9 HbA1c Women rs7077479 A C 0.337 0.140 0.022 3.9E-10 39.2 HbA1c Women rs701848 C T 0.390 -0.118 0.021 3.2E-08 30.6 HbA1c Women rs11187149 A G 0.381 -0.189 0.021 9.1E-19 78.3 HbA1c Women rs4418728 T G 0.449 -0.152 0.021 3.5E-13 52.9 HbA1c Women rs12365580 A G 0.151 -0.209 0.029 7.6E-13 51.4 HbA1c Women rs11042850 A G 0.087 0.292 0.037 2.0E-15 63.1 HbA1c Women rs7944748 G T 0.378 0.119 0.022 3.2E-08 30.6 HbA1c Women rs2351960 G A 0.893 -0.219 0.034 7.8E-11 42.3 HbA1c Women rs3782123 A C 0.733 -0.203 0.024 6.9E-18 74.3 HbA1c Women rs11564725 T C 0.236 0.202 0.025 3.1E-16 66.7 HbA1c Women rs4755950 T C 0.113 -0.187 0.033 1.2E-08 32.5 HbA1c Women rs10501320 C G 0.264 -0.194 0.024 1.8E-16 67.8 HbA1c Women rs174598 A G 0.329 -0.148 0.022 2.4E-11 44.6 HbA1c Women rs12294913 G C 0.050 0.299 0.050 1.6E-09 36.4 HbA1c Women rs11602873 T A 0.157 -0.224 0.029 4.3E-15 61.6 HbA1c Women rs10830963 G C 0.275 0.434 0.023 1.7E-77 347.5 HbA1c Women rs1392026 T C 0.635 -0.175 0.022 7.3E-16 65.1 HbA1c Women rs7310615 G C 0.517 0.188 0.021 2.9E-19 80.5 HbA1c Women rs2936839 C T 0.610 -0.129 0.021 1.6E-09 36.4 HbA1c Women rs147730268 T G 0.091 -0.229 0.037 9.2E-10 37.5 HbA1c Women rs10842994 T C 0.196 -0.156 0.026 2.4E-09 35.7 HbA1c Women rs76895963 G T 0.020 -1.082 0.080 1.1E-41 183.1 HbA1c Women rs10492081 G A 0.180 0.198 0.027 2.4E-13 53.7 HbA1c Women rs4760682 A C 0.813 0.501 0.027 5.8E-79 354.3 HbA1c Women rs35979828 T C 0.069 -0.236 0.041 8.9E-09 33.1 HbA1c Women rs2261181 T C 0.096 0.244 0.035 5.8E-12 47.4 HbA1c Women rs1579238 G A 0.241 -0.157 0.024 1.1E-10 41.6 HbA1c Women rs34011672 G A 0.089 0.562 0.037 4.0E-53 235.5 HbA1c Women rs12861645 G T 0.272 0.241 0.023 8.1E-25 105.8 HbA1c Women rs11616945 C T 0.337 0.140 0.022 4.0E-10 39.1 HbA1c Women rs12020979 G T 0.185 -0.268 0.028 6.3E-22 92.7 HbA1c Women rs4325403 A T 0.220 0.231 0.025 1.0E-19 82.6 HbA1c Women rs75629141 A T 0.829 -0.164 0.028 3.0E-09 35.2 HbA1c Women rs941899 C T 0.529 -0.135 0.021 8.7E-11 42.1 HbA1c Women rs9324022 C T 0.206 0.163 0.026 5.6E-10 38.5 HbA1c Women rs1760940 C A 0.248 0.176 0.024 2.4E-13 53.6 ### Page 43 HbA1c Women rs941718 C T 0.278 0.151 0.023 7.3E-11 42.4 HbA1c Women rs8018574 A T 0.243 -0.154 0.024 2.4E-10 40.1 HbA1c Women rs12878001 G T 0.160 0.160 0.029 2.1E-08 31.4 HbA1c Women rs229572 A T 0.235 0.190 0.025 8.5E-15 60.2 HbA1c Women rs35889227 T G 0.631 -0.143 0.022 3.3E-11 44.0 HbA1c Women rs4516170 C T 0.050 -0.313 0.048 5.8E-11 42.9 HbA1c Women rs1550026 T A 0.408 0.137 0.021 1.1E-10 41.6 HbA1c Women rs869301 C T 0.720 0.192 0.023 1.2E-16 68.6 HbA1c Women rs11638511 G A 0.561 0.126 0.021 2.2E-09 35.8 HbA1c Women rs4451969 C T 0.671 -0.150 0.022 1.5E-11 45.6 HbA1c Women rs9302377 T C 0.493 0.123 0.022 2.5E-08 31.1 HbA1c Women rs6600191 C T 0.181 -0.218 0.027 9.5E-16 64.5 HbA1c Women rs35661204 T C 0.226 0.189 0.025 3.2E-14 57.6 HbA1c Women rs8050500 C T 0.446 -0.162 0.021 1.1E-14 59.8 HbA1c Women rs11075985 A C 0.423 0.124 0.021 3.8E-09 34.7 HbA1c Women rs9929239 T C 0.292 0.159 0.023 3.0E-12 48.7 HbA1c Women rs247828 C A 0.305 0.138 0.023 9.8E-10 37.4 HbA1c Women rs72811487 A G 0.035 -0.413 0.056 2.0E-13 54.1 HbA1c Women rs551118 G C 0.578 0.372 0.021 1.1E-67 302.4 HbA1c Women rs11655029 C T 0.695 -0.211 0.023 1.1E-20 87.0 HbA1c Women rs6902 C A 0.386 -0.118 0.021 3.4E-08 30.5 HbA1c Women rs12450826 T A 0.293 -0.172 0.023 2.4E-13 53.7 HbA1c Women rs11651755 T C 0.515 -0.133 0.021 1.7E-10 40.8 HbA1c Women rs2060779 A G 0.222 -0.176 0.025 2.3E-12 49.3 HbA1c Women rs9899611 G A 0.213 0.163 0.025 1.3E-10 41.3 HbA1c Women rs858518 A G 0.573 -0.144 0.021 7.6E-12 46.9 HbA1c Women rs2748427 G A 0.218 0.637 0.025 5.2E-142 644.8 HbA1c Women rs112281307 C A 0.094 0.229 0.036 1.2E-10 41.5 HbA1c Women rs9909940 T C 0.312 0.474 0.022 3.2E-99 447.6 HbA1c Women rs4792590 G A 0.877 -0.215 0.032 1.2E-11 45.9 HbA1c Women rs4542747 T C 0.746 0.153 0.024 1.7E-10 40.8 HbA1c Women rs8110787 T C 0.391 -0.212 0.021 2.0E-23 99.4 HbA1c Women rs4808579 C T 0.392 0.300 0.021 7.7E-45 197.5 HbA1c Women rs4499344 A G 0.293 -0.211 0.023 2.7E-20 85.2 HbA1c Women rs10410896 A C 0.890 0.199 0.034 3.7E-09 34.8 HbA1c Women rs55914970 T G 0.441 -0.154 0.021 2.2E-13 53.8 HbA1c Women rs12459419 T C 0.326 -0.163 0.022 2.0E-13 54.1 HbA1c Women rs7250849 T G 0.106 0.235 0.034 3.8E-12 48.2 HbA1c Women rs351988 G A 0.565 -0.117 0.021 3.3E-08 30.5 HbA1c Women rs1975283 C A 0.685 -0.169 0.023 6.6E-14 56.2 HbA1c Women rs267738 G T 0.221 -0.201 0.025 9.0E-16 64.7 HbA1c Women rs4133213 A C 0.450 -0.121 0.021 1.5E-08 32.1 HbA1c Women rs857721 A T 0.267 0.504 0.023 1.8E-102 462.6 HbA1c Women rs7528296 C T 0.386 -0.130 0.021 1.1E-09 37.1 HbA1c Women rs1044145 C T 0.540 0.155 0.021 1.3E-13 54.8 HbA1c Women rs340882 G C 0.621 0.254 0.022 4.8E-32 138.9 HbA1c Women rs348330 A G 0.635 -0.131 0.022 1.5E-09 36.5 HbA1c Women rs1339847 A G 0.110 -0.224 0.033 1.7E-11 45.3 ### Page 44 HbA1c Women rs2301153 C G 0.799 -0.171 0.028 4.9E-10 38.7 HbA1c Women rs563437995 C G 0.008 -1.019 0.123 1.1E-16 68.8 HbA1c Women rs1175550 G A 0.230 -0.268 0.025 1.1E-26 114.4 HbA1c Women rs12141885 T C 0.700 -0.126 0.023 2.6E-08 31.0 HbA1c Women rs1768809 C A 0.556 0.132 0.021 3.0E-10 39.7 HbA1c Women rs12121576 G A 0.183 -0.163 0.028 4.9E-09 34.2 HbA1c Women rs149142833 T C 0.156 0.165 0.029 1.2E-08 32.5 HbA1c Women rs6066148 C G 0.262 -0.144 0.024 1.3E-09 36.8 HbA1c Women rs6014993 G A 0.487 0.204 0.021 1.5E-22 95.6 HbA1c Women rs73129526 C T 0.144 0.168 0.030 1.4E-08 32.2 HbA1c Women rs6077396 A G 0.507 -0.114 0.021 4.4E-08 30.0 HbA1c Women rs3827181 T C 0.346 0.131 0.022 2.3E-09 35.7 HbA1c Women rs61138219 T C 0.153 -0.160 0.029 3.3E-08 30.5 HbA1c Women rs17850433 C T 0.012 0.624 0.095 4.7E-11 43.3 HbA1c Women rs62221525 T C 0.179 -0.168 0.027 7.1E-10 38.0 HbA1c Women rs4680 A G 0.516 0.119 0.021 9.4E-09 33.0 HbA1c Women rs6518681 G A 0.907 0.206 0.036 1.0E-08 32.8 HbA1c Women rs855791 G A 0.561 -0.417 0.021 1.3E-87 394.1 HbA1c Women rs2143918 C A 0.471 -0.166 0.021 1.9E-15 63.1 HbA1c Women rs111631066 A G 0.015 -0.550 0.087 2.8E-10 39.8 HbA1c Women rs180935712 A G 0.019 0.533 0.078 9.8E-12 46.4 HbA1c Women rs143869345 G A 0.017 0.681 0.082 1.1E-16 68.9 HbA1c Women rs560887 C T 0.701 0.738 0.023 1.2E-232 1063.7 HbA1c Women rs4972439 C T 0.220 -0.192 0.025 2.6E-14 58.0 HbA1c Women rs1047891 A C 0.316 -0.154 0.022 5.6E-12 47.5 HbA1c Women rs13427681 C G 0.562 0.129 0.021 7.0E-10 38.0 HbA1c Women rs2943640 C A 0.652 0.121 0.022 2.7E-08 30.9 HbA1c Women rs7346 A G 0.191 -0.163 0.027 7.7E-10 37.8 HbA1c Women rs72780125 C T 0.131 0.429 0.031 8.3E-44 192.8 HbA1c Women rs7595986 A G 0.781 -0.156 0.025 5.1E-10 38.7 HbA1c Women rs1504 G T 0.444 -0.116 0.021 2.9E-08 30.8 HbA1c Women rs112694524 A G 0.072 -0.469 0.041 2.0E-30 131.4 HbA1c Women rs2121564 G C 0.129 0.169 0.031 4.8E-08 29.8 HbA1c Women rs78583604 T G 0.132 0.175 0.032 3.1E-08 30.6 HbA1c Women rs13019832 A G 0.418 -0.149 0.021 2.2E-12 49.3 HbA1c Women rs7572278 A T 0.204 0.175 0.026 1.2E-11 45.9 HbA1c Women rs9826367 G A 0.449 -0.258 0.021 5.2E-35 152.4 HbA1c Women rs11708067 G A 0.245 -0.392 0.024 2.8E-59 263.8 HbA1c Women rs6807945 T C 0.837 -0.186 0.028 5.7E-11 42.9 HbA1c Women rs77630894 T G 0.049 -0.266 0.048 3.8E-08 30.3 HbA1c Women rs12493136 A G 0.164 0.200 0.028 1.3E-12 50.3 HbA1c Women rs16831139 G A 0.400 -0.137 0.022 2.5E-10 40.0 HbA1c Women rs5398 A G 0.285 -0.284 0.023 4.6E-35 152.7 HbA1c Women rs360408 A T 0.565 -0.123 0.021 9.8E-09 32.9 HbA1c Women rs16856859 G A 0.583 0.199 0.021 5.0E-21 88.5 HbA1c Women rs10222374 T C 0.785 0.152 0.026 2.6E-09 35.4 HbA1c Women rs6777684 G A 0.610 0.173 0.021 5.4E-16 65.6 HbA1c Women rs2686588 G C 0.565 -0.133 0.021 2.2E-10 40.3 ### Page 45 HbA1c Women rs62246446 G C 0.176 -0.166 0.027 1.1E-09 37.1 HbA1c Women rs67882627 T A 0.171 0.251 0.028 1.1E-19 82.4 HbA1c Women rs11130982 G T 0.711 0.178 0.023 1.3E-14 59.5 HbA1c Women rs223376 A T 0.485 -0.122 0.021 5.6E-09 34.0 HbA1c Women rs17430251 G A 0.122 0.178 0.032 2.1E-08 31.4 HbA1c Women rs2298978 A G 0.403 -0.142 0.021 2.5E-11 44.6 HbA1c Women rs6814613 C G 0.665 -0.364 0.023 1.1E-58 261.0 HbA1c Women rs34835465 C T 0.070 -0.295 0.041 5.8E-13 51.9 HbA1c Women rs6840504 T C 0.443 0.127 0.021 1.5E-09 36.5 HbA1c Women rs11132255 A G 0.161 -0.237 0.028 5.9E-17 70.0 HbA1c Women rs11731874 C T 0.575 0.123 0.021 6.5E-09 33.7 HbA1c Women rs2622622 G C 0.314 -0.158 0.023 2.9E-12 48.8 HbA1c Women rs112034864 G C 0.503 0.141 0.021 1.9E-11 45.1 HbA1c Women rs6885132 G C 0.099 -0.252 0.035 9.5E-13 51.0 HbA1c Women rs4704834 G A 0.646 0.181 0.022 1.1E-16 68.9 HbA1c Women rs4496693 C T 0.094 0.219 0.036 9.1E-10 37.5 HbA1c Women rs17419291 C T 0.087 -0.211 0.037 1.0E-08 32.8 HbA1c Women rs35247507 G A 0.286 -0.164 0.023 1.3E-12 50.4 HbA1c Women rs13214717 A C 0.299 -0.165 0.023 3.7E-13 52.8 HbA1c Women rs72939920 T A 0.235 -0.205 0.025 7.1E-17 69.7 HbA1c Women rs9385400 G T 0.455 0.160 0.021 1.9E-14 58.6 HbA1c Women rs9376091 T C 0.262 -0.274 0.024 1.0E-30 132.8 HbA1c Women rs592423 C A 0.554 -0.114 0.021 4.6E-08 29.9 HbA1c Women rs6920313 C T 0.306 0.131 0.023 6.4E-09 33.7 HbA1c Women rs9368219 T C 0.173 0.282 0.028 1.6E-24 104.6 HbA1c Women rs1800562 A G 0.079 -0.871 0.039 7.0E-113 510.5 HbA1c Women rs2071596 A G 0.163 -0.232 0.028 1.4E-16 68.2 HbA1c Women rs11967891 T A 0.181 0.320 0.028 3.7E-30 130.3 HbA1c Women rs9272606 T C 0.660 0.127 0.022 8.6E-09 33.1 HbA1c Women rs998584 A C 0.482 0.191 0.021 4.9E-20 84.0 HbA1c Women rs34101263 A G 0.299 0.148 0.023 6.6E-11 42.6 HbA1c Women rs3748059 G A 0.799 -0.168 0.026 9.6E-11 41.9 HbA1c Women rs78588343 A G 0.179 -0.268 0.027 5.1E-23 97.6 HbA1c Women rs75759008 G A 0.080 -0.284 0.038 1.2E-13 55.1 HbA1c Women rs12154627 C T 0.498 -0.120 0.021 1.3E-08 32.3 HbA1c Women rs17168486 T C 0.173 0.190 0.028 6.7E-12 47.1 HbA1c Women rs1974620 T C 0.549 0.153 0.021 3.4E-13 53.0 HbA1c Women rs62491945 A G 0.347 -0.125 0.022 8.7E-09 33.1 HbA1c Women rs864745 C T 0.506 -0.170 0.021 2.6E-16 67.1 HbA1c Women rs2908277 A G 0.120 0.333 0.032 2.2E-25 108.4 HbA1c Women rs1799884 T C 0.178 0.769 0.027 2.4E-177 807.9 HbA1c Women rs868961 T G 0.340 0.132 0.022 1.8E-09 36.2 HbA1c Women rs6973494 A C 0.516 0.120 0.021 1.3E-08 32.3 HbA1c Women rs117370443 C T 0.039 0.335 0.054 4.7E-10 38.8 HbA1c Women rs7820334 T C 0.311 -0.143 0.023 2.6E-10 40.0 HbA1c Women rs55780214 A T 0.290 -0.192 0.023 7.1E-17 69.7 HbA1c Women rs13266634 T C 0.311 -0.369 0.022 1.3E-60 269.9 HbA1c Women rs2060984 C T 0.450 -0.119 0.021 1.2E-08 32.5 ### Page 46 HbA1c Women rs6474359 C T 0.038 -0.854 0.054 2.3E-55 245.8 HbA1c Women rs4737010 A G 0.228 0.471 0.025 1.8E-80 361.3 HbA1c Women rs55840085 A G 0.355 0.157 0.022 4.8E-13 52.3 HbA1c Women rs7042939 G A 0.620 -0.199 0.022 3.8E-20 84.5 HbA1c Women rs41273438 G A 0.041 0.322 0.052 7.9E-10 37.8 HbA1c Women rs5900831 G T 0.653 0.142 0.022 1.5E-10 41.0 HbA1c Women rs550057 T C 0.255 0.287 0.024 3.8E-33 143.9 HbA1c Women rs28641468 C T 0.756 0.256 0.024 2.7E-26 112.6 HbA1c Women rs10811660 A G 0.173 -0.334 0.027 4.7E-34 148.1 HbA1c Women rs2236495 C T 0.208 -0.192 0.026 7.9E-14 55.8 HbA1c Women rs11145347 C T 0.197 0.221 0.026 2.7E-17 71.6 HbA1c Women rs61750929 T C 0.055 -0.716 0.046 2.5E-55 245.7 HbA1c Men rs114322470 G T 0.019 -0.565 0.086 5.1E-11 43.1 HbA1c Men rs34872471 C T 0.291 0.555 0.026 1.2E-104 472.6 HbA1c Men rs11257655 T C 0.208 0.256 0.029 3.0E-19 80.5 HbA1c Men rs7904973 T G 0.576 0.135 0.023 1.0E-08 32.8 HbA1c Men rs3780962 G A 0.532 0.135 0.023 7.4E-09 33.4 HbA1c Men rs56197478 G A 0.223 -0.256 0.028 9.5E-20 82.7 HbA1c Men rs550048289 G T 0.015 -0.830 0.102 3.9E-16 66.3 HbA1c Men rs1106676 G T 0.656 0.290 0.024 2.0E-32 140.6 HbA1c Men rs11812380 C T 0.012 0.757 0.111 7.9E-12 46.8 HbA1c Men rs10159477 A G 0.149 -1.770 0.032 0.0E+00 2999.4 HbA1c Men rs749108 T C 0.696 0.158 0.026 6.2E-10 38.3 HbA1c Men rs12219514 G A 0.434 -0.207 0.023 1.1E-18 78.0 HbA1c Men rs1502276 A G 0.184 -0.176 0.030 5.4E-09 34.0 HbA1c Men rs7127313 T C 0.346 0.198 0.024 6.2E-16 65.4 HbA1c Men rs6484302 T C 0.176 0.223 0.031 4.3E-13 52.5 HbA1c Men rs7124355 G A 0.675 -0.138 0.025 3.1E-08 30.7 HbA1c Men rs12419995 T A 0.656 -0.235 0.026 5.3E-20 83.9 HbA1c Men rs2237895 C A 0.415 0.211 0.024 3.0E-19 80.5 HbA1c Men rs11039165 G A 0.271 -0.167 0.026 1.6E-10 40.9 HbA1c Men rs174533 A G 0.347 -0.192 0.024 3.5E-15 62.0 HbA1c Men rs9667947 C T 0.161 -0.252 0.032 1.6E-15 63.5 HbA1c Men rs10830963 G C 0.275 0.436 0.026 1.1E-63 284.1 HbA1c Men rs360140 A C 0.643 -0.283 0.024 2.1E-31 135.9 HbA1c Men rs7137828 T C 0.517 0.200 0.023 9.5E-18 73.6 HbA1c Men rs112066678 C A 0.054 0.294 0.051 9.3E-09 33.0 HbA1c Men rs9668691 C T 0.232 -0.202 0.028 2.5E-13 53.5 HbA1c Men rs4238013 T C 0.796 -0.165 0.029 1.5E-08 32.1 HbA1c Men rs76895963 G T 0.020 -1.488 0.089 2.3E-62 278.0 HbA1c Men rs12819124 A C 0.472 -0.451 0.023 2.6E-83 374.4 HbA1c Men rs6580661 T A 0.224 0.215 0.028 1.4E-14 59.3 HbA1c Men rs143343646 G A 0.063 -0.266 0.049 4.5E-08 29.9 HbA1c Men rs79755767 A G 0.100 -0.243 0.039 5.6E-10 38.5 HbA1c Men rs343087 G A 0.861 -0.191 0.034 1.3E-08 32.3 HbA1c Men rs79621919 A G 0.059 -0.299 0.049 1.5E-09 36.6 HbA1c Men rs420431 G C 0.122 0.482 0.035 4.0E-42 185.1 HbA1c Men rs7329468 T C 0.217 -0.270 0.028 2.6E-21 89.8 ### Page 47 HbA1c Men rs11149501 C T 0.223 0.203 0.028 5.2E-13 52.1 HbA1c Men rs2858980 A G 0.833 -0.264 0.031 2.2E-17 72.0 HbA1c Men rs1359790 A G 0.289 -0.199 0.026 6.9E-15 60.6 HbA1c Men rs561278583 C G 0.206 0.168 0.029 5.3E-09 34.1 HbA1c Men rs12886807 T C 0.242 -0.153 0.028 3.5E-08 30.4 HbA1c Men rs12434326 C G 0.249 -0.177 0.027 4.8E-11 43.3 HbA1c Men rs2285005 A G 0.340 0.203 0.025 1.6E-16 68.1 HbA1c Men rs10873398 A G 0.646 -0.162 0.024 2.6E-11 44.5 HbA1c Men rs113204516 G A 0.049 -0.350 0.054 1.1E-10 41.6 HbA1c Men rs7167567 A T 0.423 0.155 0.024 4.6E-11 43.3 HbA1c Men rs11633054 G A 0.713 0.210 0.026 3.3E-16 66.6 HbA1c Men rs62022948 T C 0.329 -0.138 0.025 2.5E-08 31.0 HbA1c Men rs1866476 C T 0.732 -0.170 0.026 1.0E-10 41.8 HbA1c Men rs396263 G A 0.211 0.161 0.029 1.5E-08 32.1 HbA1c Men rs165975 C T 0.234 0.173 0.028 3.2E-10 39.6 HbA1c Men rs184499898 G A 0.011 0.715 0.116 6.4E-10 38.2 HbA1c Men rs181205 C T 0.343 0.208 0.025 3.9E-17 70.8 HbA1c Men rs2858010 C T 0.340 -0.185 0.025 5.8E-14 56.4 HbA1c Men rs8050500 C T 0.446 -0.199 0.023 2.0E-17 72.1 HbA1c Men rs7188250 C T 0.414 0.175 0.024 1.3E-13 54.9 HbA1c Men rs35158985 G A 0.308 0.162 0.025 1.3E-10 41.3 HbA1c Men rs247826 T C 0.223 0.229 0.028 3.0E-16 66.8 HbA1c Men rs72811487 A G 0.035 -0.357 0.063 1.8E-08 31.7 HbA1c Men rs551118 G C 0.578 0.394 0.024 2.9E-61 272.9 HbA1c Men rs1108646 G A 0.682 -0.243 0.025 4.8E-22 93.2 HbA1c Men rs71373617 T C 0.320 -0.162 0.025 9.4E-11 42.0 HbA1c Men rs216195 G T 0.303 0.154 0.025 9.9E-10 37.3 HbA1c Men rs9303620 C T 0.278 -0.201 0.026 9.3E-15 60.1 HbA1c Men rs17698176 G T 0.229 0.173 0.028 6.0E-10 38.3 HbA1c Men rs12600858 A G 0.224 -0.237 0.028 2.2E-17 72.0 HbA1c Men rs8064261 A G 0.275 -0.157 0.026 1.8E-09 36.2 HbA1c Men rs1030097 G C 0.495 0.128 0.023 4.1E-08 30.1 HbA1c Men rs1641523 T C 0.567 -0.245 0.024 3.8E-25 107.4 HbA1c Men rs2748427 G A 0.218 0.436 0.028 3.6E-54 240.4 HbA1c Men rs113373052 T C 0.313 0.463 0.025 7.7E-76 340.0 HbA1c Men rs8078338 G A 0.506 -0.169 0.023 4.0E-13 52.6 HbA1c Men rs6507691 C T 0.749 0.184 0.027 7.7E-12 46.8 HbA1c Men rs17533945 C T 0.392 0.337 0.024 6.9E-45 197.7 HbA1c Men rs10401969 C T 0.077 0.263 0.044 2.0E-09 36.0 HbA1c Men rs75372982 G A 0.289 -0.175 0.026 1.6E-11 45.4 HbA1c Men rs584007 G A 0.641 -0.184 0.024 3.6E-14 57.4 HbA1c Men rs35255921 A G 0.013 -0.581 0.101 9.2E-09 33.0 HbA1c Men rs62111724 C T 0.366 -0.207 0.024 2.4E-17 71.8 HbA1c Men rs12985029 A G 0.340 -0.157 0.025 1.6E-10 40.9 HbA1c Men rs1975283 C A 0.685 -0.164 0.025 6.6E-11 42.6 HbA1c Men rs587739738 T C 0.083 -0.284 0.042 1.8E-11 45.2 HbA1c Men rs857720 C T 0.267 0.591 0.026 4.1E-112 507.1 HbA1c Men rs2228445 C T 0.902 0.283 0.039 4.5E-13 52.4 ### Page 48 HbA1c Men rs79687284 C G 0.035 0.603 0.063 1.5E-21 90.9 HbA1c Men rs238763 A T 0.592 -0.169 0.024 1.1E-12 50.6 HbA1c Men rs3811444 T C 0.334 0.192 0.025 5.8E-15 61.0 HbA1c Men rs4518840 T A 0.878 -0.279 0.036 9.2E-15 60.1 HbA1c Men rs114247628 A G 0.006 -1.373 0.159 5.1E-18 74.9 HbA1c Men rs1175550 G A 0.230 -0.304 0.028 2.4E-27 117.4 HbA1c Men rs3768321 T G 0.197 0.212 0.029 4.6E-13 52.4 HbA1c Men rs3789586 T C 0.153 -0.248 0.032 1.7E-14 58.9 HbA1c Men rs7513688 A G 0.361 0.149 0.024 9.3E-10 37.5 HbA1c Men rs2065703 T C 0.159 0.179 0.032 1.9E-08 31.6 HbA1c Men rs6063050 C T 0.283 -0.162 0.026 4.8E-10 38.8 HbA1c Men rs6014993 G A 0.487 0.146 0.023 4.0E-10 39.1 HbA1c Men rs2427361 A C 0.620 -0.151 0.024 4.9E-10 38.7 HbA1c Men rs6086540 C G 0.507 -0.173 0.023 1.2E-13 55.0 HbA1c Men rs17850433 C T 0.012 0.647 0.108 1.8E-09 36.2 HbA1c Men rs59923178 G T 0.096 -0.251 0.039 2.0E-10 40.5 HbA1c Men rs77696994 T C 0.076 -0.301 0.044 1.0E-11 46.3 HbA1c Men rs855791 G A 0.561 -0.428 0.023 3.3E-74 332.5 HbA1c Men rs8138197 A G 0.471 -0.210 0.023 1.7E-19 81.6 HbA1c Men rs830021 C A 0.697 -0.153 0.025 1.7E-09 36.3 HbA1c Men rs560887 C T 0.701 0.685 0.025 1.1E-161 735.8 HbA1c Men rs13031216 T C 0.220 -0.195 0.028 3.4E-12 48.4 HbA1c Men rs1399623 C A 0.623 0.186 0.024 1.7E-14 58.9 HbA1c Men rs838717 A G 0.566 0.133 0.023 1.3E-08 32.3 HbA1c Men rs113362373 G A 0.135 0.269 0.034 2.9E-15 62.3 HbA1c Men rs780093 C T 0.618 0.237 0.024 3.2E-23 98.6 HbA1c Men rs10173636 G C 0.130 -0.456 0.035 8.9E-40 174.3 HbA1c Men rs2164701 C G 0.140 0.235 0.034 2.6E-12 49.0 HbA1c Men rs77000664 G A 0.177 0.169 0.031 3.5E-08 30.4 HbA1c Men rs7606173 C G 0.431 -0.182 0.023 8.1E-15 60.3 HbA1c Men rs7572278 A T 0.204 0.214 0.029 1.1E-13 55.2 HbA1c Men rs7638232 A G 0.418 -0.263 0.024 6.3E-29 124.6 HbA1c Men rs11708067 G A 0.245 -0.313 0.027 6.0E-31 133.9 HbA1c Men rs12497133 A G 0.533 0.148 0.023 2.6E-10 39.9 HbA1c Men rs6785881 T C 0.481 -0.153 0.023 5.8E-11 42.9 HbA1c Men rs1905505 A G 0.284 -0.283 0.026 5.2E-28 120.4 HbA1c Men rs12633493 T C 0.586 0.184 0.024 7.6E-15 60.5 HbA1c Men rs6780171 A T 0.313 0.210 0.025 6.9E-17 69.7 HbA1c Men rs2041965 T C 0.344 -0.144 0.024 3.9E-09 34.7 HbA1c Men rs6777684 G A 0.610 0.178 0.024 1.2E-13 55.0 HbA1c Men rs1496653 G A 0.204 -0.159 0.029 3.5E-08 30.4 HbA1c Men rs12715435 A G 0.171 0.267 0.031 7.8E-18 74.0 HbA1c Men rs11728350 G A 0.125 0.198 0.035 1.8E-08 31.7 HbA1c Men rs9994509 G A 0.393 -0.134 0.024 1.9E-08 31.6 HbA1c Men rs2044341 C T 0.684 -0.358 0.025 2.5E-46 204.4 HbA1c Men rs17462188 T C 0.690 0.152 0.025 2.2E-09 35.8 HbA1c Men rs111537480 G A 0.138 -0.216 0.034 2.4E-10 40.1 HbA1c Men rs225176 G C 0.671 -0.146 0.026 1.3E-08 32.3 ### Page 49 HbA1c Men rs59816691 G C 0.669 0.137 0.025 3.5E-08 30.4 HbA1c Men rs258217 G A 0.464 -0.157 0.024 5.1E-11 43.2 HbA1c Men rs7720275 C T 0.170 0.180 0.031 6.9E-09 33.6 HbA1c Men rs7732130 A G 0.681 -0.249 0.025 1.4E-23 100.1 HbA1c Men rs34533653 A T 0.266 -0.149 0.026 1.5E-08 32.0 HbA1c Men rs12210538 G A 0.236 -0.183 0.027 2.1E-11 44.8 HbA1c Men rs56293029 A C 0.259 -0.308 0.027 2.0E-30 131.4 HbA1c Men rs62440928 A G 0.607 -0.158 0.024 5.1E-11 43.2 HbA1c Men rs12201779 T C 0.395 -0.143 0.024 2.2E-09 35.8 HbA1c Men rs2665357 C A 0.517 0.142 0.023 1.1E-09 37.1 HbA1c Men rs67131976 T C 0.172 0.355 0.031 9.1E-31 133.0 HbA1c Men rs1800562 A G 0.079 -0.815 0.043 2.7E-79 355.9 HbA1c Men rs204991 C T 0.221 0.161 0.028 9.5E-09 32.9 HbA1c Men rs3135365 A C 0.769 0.257 0.028 1.2E-20 86.9 HbA1c Men rs2308891 A C 0.459 0.164 0.024 1.2E-11 46.1 HbA1c Men rs3778321 A G 0.180 -0.180 0.030 2.7E-09 35.4 HbA1c Men rs12667932 A G 0.080 -0.347 0.043 7.0E-16 65.2 HbA1c Men rs11763864 T A 0.157 0.218 0.032 8.8E-12 46.6 HbA1c Men rs11514706 C A 0.524 0.223 0.023 1.3E-21 91.2 HbA1c Men rs11982272 C T 0.202 -0.160 0.029 4.2E-08 30.0 HbA1c Men rs1708302 T C 0.501 -0.192 0.023 1.6E-16 68.0 HbA1c Men rs76323047 G A 0.118 0.336 0.036 1.1E-20 86.9 HbA1c Men rs1004558 T C 0.179 0.685 0.030 1.0E-112 509.9 HbA1c Men rs55803206 A C 0.464 0.133 0.024 2.0E-08 31.5 HbA1c Men rs117370443 C T 0.039 0.419 0.060 3.1E-12 48.6 HbA1c Men rs4300038 A G 0.311 -0.394 0.025 3.9E-55 244.8 HbA1c Men rs2954021 G A 0.506 0.211 0.023 1.0E-19 82.5 HbA1c Men rs2060985 G A 0.537 -0.130 0.023 2.2E-08 31.3 HbA1c Men rs3757974 G A 0.380 0.148 0.024 5.4E-10 38.5 HbA1c Men rs66593272 T A 0.038 -0.982 0.061 2.9E-58 259.2 HbA1c Men rs4737010 A G 0.228 0.603 0.028 1.5E-104 472.3 HbA1c Men rs55840085 A G 0.355 0.184 0.024 3.7E-14 57.3 HbA1c Men rs7829826 A T 0.534 -0.145 0.023 4.9E-10 38.7 HbA1c Men rs1967604 G A 0.712 -0.210 0.026 3.4E-16 66.6 HbA1c Men rs550057 T C 0.255 0.368 0.027 3.3E-43 190.0 HbA1c Men rs28641468 C T 0.756 0.211 0.027 5.8E-15 61.0 HbA1c Men rs10811660 A G 0.173 -0.387 0.031 2.7E-36 158.4 HbA1c Men rs10758593 A G 0.397 0.141 0.024 2.8E-09 35.3 HbA1c Men rs17803780 C T 0.211 -0.169 0.028 2.7E-09 35.4 HbA1c Men rs7025532 C T 0.199 0.261 0.029 2.4E-19 80.9 HbA1c Men rs61750929 T C 0.055 -0.668 0.051 2.8E-39 172.0 HbA1c Men rs7047279 C T 0.568 -0.161 0.024 9.1E-12 46.5 BMI, body mass index; HbA1c, glycated hemoglobin. ### Page 50 eFigure 3. IVW MR estimates for the associations of GLP-1R activation with the risk of coronary artery disease and all-cause mortalityin comparison with those for lower BMI and lower HbA1c. BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse variance weighted; MR, Mendelian randomization. Blacksquares denote genetically predicted (a) lower BMI or (b) lower HbA1c via GLP-1R activation based on variants within 1 Mb of GLP1R. White circles denote geneticallypredicted (a) lower BMI or (b) lower HbA1c based on genome-wide variants. Estimates are presented as odds ratio for coronary artery disease or hazard ratio for all-causemortality per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease in HbA1c. ### Page 51 eTable 6. MR sensitivity analyses for the associations of lower BMI and lower HbA1c with the risk of coronary artery disease and all-cause mortality. Exposure Outcome SNPs Method Estimate (95% CI) Measure P value P value(intercept) P value(Q) Lower BMI Coronary artery disease 505 IVW 0.92 (0.91 to 0.93) Odds ratio <0.001 <0.001 Lower BMI Coronary artery disease 505 Weighted median 0.92 (0.91 to 0.93) Odds ratio <0.001 Lower BMI Coronary artery disease 505 MR Egger 0.92 (0.90 to 0.95) Odds ratio <0.001 0.74 Lower BMI Coronary artery disease 505 MR-RAPS 0.91 (0.91 to 0.92) Odds ratio <0.001 Lower BMI All-cause mortality 490 IVW 0.95 (0.94 to 0.95) Hazard ratio <0.001 <0.001 Lower BMI All-cause mortality 490 Weighted median 0.94 (0.93 to 0.95) Hazard ratio <0.001 Lower BMI All-cause mortality 490 MR Egger 0.95 (0.93 to 0.97) Hazard ratio <0.001 0.51 Lower BMI All-cause mortality 490 MR-RAPS 0.94 (0.93 to 0.94) Hazard ratio <0.001 Lower BMI All-cause mortality 489 IVW(Steiger filtering) 0.94 (0.94 to 0.95) Hazard ratio <0.001 <0.001 Lower BMI All-cause mortality 489 Weighted median(Steiger filtering) 0.94 (0.93 to 0.95) Hazard ratio <0.001 Lower BMI All-cause mortality 489 MR Egger(Steiger filtering) 0.94 (0.93 to 0.96) Hazard ratio <0.001 0.86 Lower BMI All-cause mortality 489 MR-RAPS(Steiger filtering) 0.94 (0.93 to 0.94) Hazard ratio <0.001 Lower HbA1c Coronary artery disease 303 IVW 0.97 (0.97 to 0.98) Odds ratio <0.001 <0.001 Lower HbA1c Coronary artery disease 303 Weighted median 0.98 (0.97 to 0.98) Odds ratio <0.001 Lower HbA1c Coronary artery disease 303 MR Egger 0.99 (0.97 to 1.00) Odds ratio 0.04 0.006 Lower HbA1c Coronary artery disease 303 MR-RAPS 0.97 (0.97 to 0.98) Odds ratio <0.001 Lower HbA1c All-cause mortality 286 IVW 0.99 (0.99 to 1.00) Hazard ratio <0.001 <0.001 Lower HbA1c All-cause mortality 286 Weighted median 1.00 (0.99 to 1.00) Hazard ratio 0.05 Lower HbA1c All-cause mortality 286 MR Egger 1.00 (1.00 to 1.01) Hazard ratio 0.14 <0.001 Lower HbA1c All-cause mortality 286 MR-RAPS 0.99 (0.99 to 0.99) Hazard ratio <0.001 ### Page 52 BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse variance weighted; MR, Mendelian randomization; RAPS,robust adjusted profile score. Estimates are presented per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease in HbA1c. ### Page 53 eFigure 4. IVW MR estimates for sex-specific associations of GLP-1R activation with the risk of depressive symptoms in comparisonwith those for lower BMI and lower HbA1c. BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse variance weighted; MR, Mendelian randomization. Blacksquares denote genetically predicted (a) lower BMI or (b) lower HbA1c via GLP-1R activation based on variants within 1 Mb of GLP1R. White circles denote geneticallypredicted (a) lower BMI or (b) lower HbA1c based on genome-wide variants. Estimates are presented as odds ratio per 1-kg/m2 decrease in BMI or per 1-mmol/mol decreasein HbA1c. ### Page 54 eTable 7. MR sensitivity analyses for the associations of lower BMI and lower HbA1c with mental health well-being. Exposure Outcome Sex SNPs Method Estimate (95% CI) Measure P value P value(intercept) P value(Q) Lower BMI Well-being spectrum Overall 464 IVW 0.003 (0.000 to 0.01) Beta 0.04 <0.001 Lower BMI Well-being spectrum Overall 464 Weighted median 0.002 (-0.000 to 0.005) Beta 0.08 Lower BMI Well-being spectrum Overall 464 MR Egger -0.001 (-0.01 to 0.01) Beta 0.81 0.3 Lower BMI Well-being spectrum Overall 464 MR-RAPS 0.003 (0.002 to 0.005) Beta <0.001 Lower BMI Life satisfaction Overall 464 IVW 0.003 (-0.000 to 0.01) Beta 0.05 <0.001 Lower BMI Life satisfaction Overall 464 Weighted median 0.002 (-0.001 to 0.01) Beta 0.24 Lower BMI Life satisfaction Overall 464 MR Egger -0.001 (-0.01 to 0.01) Beta 0.8 0.33 Lower BMI Life satisfaction Overall 464 MR-RAPS 0.004 (0.002 to 0.01) Beta <0.001 Lower BMI Positive affect Overall 464 IVW 0.002 (-0.001 to 0.01) Beta 0.16 <0.001 Lower BMI Positive affect Overall 464 Weighted median 0.002 (-0.002 to 0.01) Beta 0.29 Lower BMI Positive affect Overall 464 MR Egger -0.001 (-0.01 to 0.01) Beta 0.76 0.41 Lower BMI Positive affect Overall 464 MR-RAPS 0.004 (0.002 to 0.01) Beta <0.001 Lower BMI Neuroticism Overall 464 IVW -0.004 (-0.01 to 0.000) Beta 0.05 <0.001 Lower BMI Neuroticism Overall 464 Weighted median -0.005 (-0.01 to -0.001) Beta 0.02 Lower BMI Neuroticism Overall 464 MR Egger 0.002 (-0.01 to 0.01) Beta 0.71 0.27 Lower BMI Neuroticism Overall 464 MR-RAPS -0.01 (-0.01 to -0.003) Beta <0.001 Lower BMI Depressive symptoms Overall 464 IVW -0.004 (-0.01 to -0.001) Beta 0.002 <0.001 Lower BMI Depressive symptoms Overall 464 Weighted median -0.003 (-0.01 to -0.001) Beta 0.02 Lower BMI Depressive symptoms Overall 464 MR Egger -0.001 (-0.01 to 0.01) Beta 0.85 0.35 Lower BMI Depressive symptoms Overall 464 MR-RAPS -0.005 (-0.01 to -0.003) Beta <0.001 Lower BMI Depressive symptoms(seen a general practitioner) Women 300 IVW 0.97 (0.95 to 0.98) Odds ratio <0.001 <0.001 Lower BMI Depressive symptoms(seen a general practitioner) Women 300 Weighted median 0.98 (0.96 to 0.99) Odds ratio 0.01 ### Page 55 Lower BMI Depressive symptoms(seen a general practitioner) Women 300 MR Egger 0.99 (0.96 to 1.03) Odds ratio 0.75 0.1 Lower BMI Depressive symptoms(seen a general practitioner) Women 300 MR-RAPS 0.97 (0.96 to 0.98) Odds ratio <0.001 Lower BMI Depressive symptoms(seen a general practitioner) Men 251 IVW 1.01 (0.99 to 1.02) Odds ratio 0.34 <0.001 Lower BMI Depressive symptoms(seen a general practitioner) Men 251 Weighted median 1.01 (0.99 to 1.03) Odds ratio 0.37 Lower BMI Depressive symptoms(seen a general practitioner) Men 251 MR Egger 1.00 (0.96 to 1.04) Odds ratio 1 0.7 Lower BMI Depressive symptoms(seen a general practitioner) Men 251 MR-RAPS 1.01 (1.00 to 1.02) Odds ratio 0.11 Lower BMI Depressive symptoms(seen a psychiatrist) Women 300 IVW 0.98 (0.96 to 0.99) Odds ratio 0.003 <0.001 Lower BMI Depressive symptoms(seen a psychiatrist) Women 300 Weighted median 0.99 (0.97 to 1.01) Odds ratio 0.25 Lower BMI Depressive symptoms(seen a psychiatrist) Women 300 MR Egger 0.99 (0.95 to 1.04) Odds ratio 0.75 0.43 Lower BMI Depressive symptoms(seen a psychiatrist) Women 300 MR-RAPS 0.98 (0.96 to 0.99) Odds ratio <0.001 Lower BMI Depressive symptoms(seen a psychiatrist) Men 251 IVW 1.00 (0.98 to 1.02) Odds ratio 0.81 <0.001 Lower BMI Depressive symptoms(seen a psychiatrist) Men 251 Weighted median 1.01 (0.98 to 1.03) Odds ratio 0.61 Lower BMI Depressive symptoms(seen a psychiatrist) Men 251 MR Egger 1.01 (0.95 to 1.06) Odds ratio 0.85 0.76 Lower BMI Depressive symptoms(seen a psychiatrist) Men 251 MR-RAPS 1.00 (0.98 to 1.02) Odds ratio 0.94 ### Page 56 Lower HbA1c Well-being spectrum Overall 242 IVW -0.001 (-0.002 to 0.001) Beta 0.35 <0.001 Lower HbA1c Well-being spectrum Overall 242 Weighted median 0.000 (-0.001 to 0.001) Beta 0.83 Lower HbA1c Well-being spectrum Overall 242 MR Egger -0.000 (-0.002 to 0.002) Beta 0.78 0.81 Lower HbA1c Well-being spectrum Overall 242 MR-RAPS -0.000 (-0.001 to 0.000) Beta 0.42 Lower HbA1c Life satisfaction Overall 242 IVW -0.001 (-0.002 to 0.001) Beta 0.42 <0.001 Lower HbA1c Life satisfaction Overall 242 Weighted median -0.000 (-0.002 to 0.002) Beta 0.96 Lower HbA1c Life satisfaction Overall 242 MR Egger -0.000 (-0.003 to 0.002) Beta 0.73 0.93 Lower HbA1c Life satisfaction Overall 242 MR-RAPS -0.000 (-0.001 to 0.001) Beta 0.49 Lower HbA1c Positive affect Overall 242 IVW -0.001 (-0.002 to 0.001) Beta 0.38 <0.001 Lower HbA1c Positive affect Overall 242 Weighted median -0.000 (-0.002 to 0.002) Beta 0.88 Lower HbA1c Positive affect Overall 242 MR Egger -0.000 (-0.003 to 0.002) Beta 0.74 0.88 Lower HbA1c Positive affect Overall 242 MR-RAPS -0.000 (-0.001 to 0.001) Beta 0.35 Lower HbA1c Neuroticism Overall 242 IVW 0.001 (-0.001 to 0.002) Beta 0.54 <0.001 Lower HbA1c Neuroticism Overall 242 Weighted median -0.000 (-0.002 to 0.002) Beta 0.74 Lower HbA1c Neuroticism Overall 242 MR Egger 0.000 (-0.003 to 0.004) Beta 0.81 0.93 Lower HbA1c Neuroticism Overall 242 MR-RAPS 0.000 (-0.001 to 0.001) Beta 0.63 Lower HbA1c Depressive symptoms Overall 242 IVW 0.000 (-0.001 to 0.001) Beta 0.63 <0.001 Lower HbA1c Depressive symptoms Overall 242 Weighted median -0.000 (-0.001 to 0.001) Beta 0.77 Lower HbA1c Depressive symptoms Overall 242 MR Egger 0.000 (-0.002 to 0.003) Beta 0.68 0.85 Lower HbA1c Depressive symptoms Overall 242 MR-RAPS 0.000 (-0.001 to 0.001) Beta 0.71 Lower HbA1c Depressive symptoms(seen a general practitioner) Women 193 IVW 1.00 (0.99 to 1.00) Odds ratio 0.53 <0.001 Lower HbA1c Depressive symptoms(seen a general practitioner) Women 193 Weighted median 1.00 (0.99 to 1.01) Odds ratio 0.68 Lower HbA1c Depressive symptoms(seen a general practitioner) Women 193 MR Egger 1.00 (0.99 to 1.01) Odds ratio 0.85 0.49 Lower HbA1c Depressive symptoms(seen a general practitioner) Women 193 MR-RAPS 1.00 (0.99 to 1.00) Odds ratio 0.43 ### Page 57 Lower HbA1c Depressive symptoms(seen a general practitioner) Men 168 IVW 1.00 (0.99 to 1.01) Odds ratio 0.92 0.005 Lower HbA1c Depressive symptoms(seen a general practitioner) Men 168 Weighted median 1.00 (0.99 to 1.01) Odds ratio 0.5 Lower HbA1c Depressive symptoms(seen a general practitioner) Men 168 MR Egger 1.00 (0.99 to 1.01) Odds ratio 0.9 0.93 Lower HbA1c Depressive symptoms(seen a general practitioner) Men 168 MR-RAPS 1.00 (1.00 to 1.01) Odds ratio 0.6 Lower HbA1c Depressive symptoms(seen a psychiatrist) Women 193 IVW 1.00 (0.99 to 1.00) Odds ratio 0.38 0.003 Lower HbA1c Depressive symptoms(seen a psychiatrist) Women 193 Weighted median 0.99 (0.98 to 1.00) Odds ratio 0.21 Lower HbA1c Depressive symptoms(seen a psychiatrist) Women 193 MR Egger 1.00 (0.99 to 1.01) Odds ratio 0.9 0.43 Lower HbA1c Depressive symptoms(seen a psychiatrist) Women 193 MR-RAPS 1.00 (0.99 to 1.00) Odds ratio 0.15 Lower HbA1c Depressive symptoms(seen a psychiatrist) Men 168 IVW 1.00 (0.99 to 1.01) Odds ratio 0.9 0.11 Lower HbA1c Depressive symptoms(seen a psychiatrist) Men 168 Weighted median 1.00 (0.98 to 1.01) Odds ratio 0.45 Lower HbA1c Depressive symptoms(seen a psychiatrist) Men 168 MR Egger 1.00 (0.98 to 1.01) Odds ratio 0.61 0.49 Lower HbA1c Depressive symptoms(seen a psychiatrist) Men 168 MR-RAPS 1.00 (0.99 to 1.01) Odds ratio 0.85 BMI, body mass index; HbA1c, glycated hemoglobin; IVW, inverse variance weighting; MR, Mendelian randomization; RAPS, robust adjusted profile score. Positiveassociations with the well-being spectrum, life satisfaction, and positive affect and negative associations with neuroticism and depressive symptoms indicate better mentalhealth well-being. Estimates are presented per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease in HbA1c. ### Page 58 eFigure 5. IVW MR estimates for sex-specific associations of GLP-1R activation with the risk of major depressive disorder,schizophrenia, and ADHD in comparison with those for lower BMI and lower HbA1c. ADHD, attention deficit hyperactivity disorder; BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse varianceweighted; MR, Mendelian randomization. Black squares denote genetically predicted (a) lower BMI or (b) lower HbA1c via GLP-1R activation based on variants within 1Mb of GLP1R. White circles denote genetically predicted (a) lower BMI or (b) lower HbA1c based on genome-wide variants. Estimates are presented as odds ratio per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease in HbA1c. ### Page 59 eTable 8. MR sensitivity analyses for the associations of lower BMI and lower HbA1c with the risk of mental health disorders. Exposure Outcome Sex SNPs Method Odds ratio (95% CI) P value P value(intercept) P value(Q) Lower BMI Major depressive disorder Overall 492 IVW 0.97 (0.96 to 0.98) <0.001 <0.001 Lower BMI Major depressive disorder Overall 492 Weighted median 0.97 (0.96 to 0.98) <0.001 Lower BMI Major depressive disorder Overall 492 MR Egger 0.99 (0.97 to 1.01) 0.26 0.04 Lower BMI Major depressive disorder Overall 492 MR-RAPS 0.97 (0.97 to 0.97) <0.001 Lower BMI Major depressive disorder Women 297 IVW 0.95 (0.93 to 0.96) <0.001 <0.001 Lower BMI Major depressive disorder Women 297 Weighted median 0.95 (0.94 to 0.97) <0.001 Lower BMI Major depressive disorder Women 297 MR Egger 0.96 (0.92 to 0.99) 0.02 0.54 Lower BMI Major depressive disorder Women 297 MR-RAPS 0.95 (0.94 to 0.95) <0.001 Lower BMI Major depressive disorder Men 249 IVW 0.98 (0.97 to 0.99) 0.003 <0.001 Lower BMI Major depressive disorder Men 249 Weighted median 0.98 (0.96 to 0.99) 0.01 Lower BMI Major depressive disorder Men 249 MR Egger 0.98 (0.94 to 1.02) 0.35 0.99 Lower BMI Major depressive disorder Men 249 MR-RAPS 0.98 (0.97 to 0.99) <0.001 Lower BMI Post-partum depression Women 300 IVW 0.98 (0.96 to 1.00) 0.03 <0.001 Lower BMI Post-partum depression Women 300 Weighted median 0.99 (0.96 to 1.02) 0.45 Lower BMI Post-partum depression Women 300 MR Egger 0.98 (0.93 to 1.04) 0.57 0.81 Lower BMI Post-partum depression Women 300 MR-RAPS 0.98 (0.96 to 1.00) 0.01 Lower BMI Bipolar disorder Overall 506 IVW 1.00 (0.98 to 1.02) 0.77 <0.001 Lower BMI Bipolar disorder Overall 506 Weighted median 1.00 (0.98 to 1.03) 0.87 Lower BMI Bipolar disorder Overall 506 MR Egger 0.97 (0.92 to 1.02) 0.27 0.19 Lower BMI Bipolar disorder Overall 506 MR-RAPS 1.00 (0.99 to 1.01) 0.88 Lower BMI Bipolar disorder I Overall 499 IVW 1.01 (0.98 to 1.03) 0.57 <0.001 Lower BMI Bipolar disorder I Overall 499 Weighted median 1.00 (0.97 to 1.03) 0.93 Lower BMI Bipolar disorder I Overall 499 MR Egger 0.96 (0.90 to 1.02) 0.2 0.11 Lower BMI Bipolar disorder I Overall 499 MR-RAPS 1.00 (0.98 to 1.02) 0.95 Lower BMI Bipolar disorder II Overall 499 IVW 1.00 (0.97 to 1.03) 0.94 <0.001 ### Page 60 Lower BMI Bipolar disorder II Overall 499 Weighted median 0.99 (0.95 to 1.04) 0.82 Lower BMI Bipolar disorder II Overall 499 MR Egger 0.98 (0.90 to 1.05) 0.52 0.51 Lower BMI Bipolar disorder II Overall 499 MR-RAPS 1.00 (0.97 to 1.02) 0.79 Lower BMI PTSD Overall 506 IVW 0.94 (0.92 to 0.96) <0.001 <0.001 Lower BMI PTSD Overall 506 Weighted median 0.94 (0.91 to 0.97) <0.001 Lower BMI PTSD Overall 506 MR Egger 0.96 (0.91 to 1.01) 0.13 0.36 Lower BMI PTSD Overall 506 MR-RAPS 0.94 (0.92 to 0.95) <0.001 Lower BMI Schizophrenia Overall 505 IVW 1.03 (1.01 to 1.05) 0.01 <0.001 Lower BMI Schizophrenia Overall 505 Weighted median 1.00 (0.98 to 1.03) 0.72 Lower BMI Schizophrenia Overall 505 MR Egger 0.93 (0.88 to 0.99) 0.02 <0.001 Lower BMI Schizophrenia Overall 505 MR-RAPS 1.02 (1.01 to 1.03) 0.002 Lower BMI Schizophrenia Overall 498 IVW(Steiger filtering) 1.03 (1.01 to 1.05) 0.004 <0.001 Lower BMI Schizophrenia Overall 498 Weighted median(Steiger filtering) 1.00 (0.98 to 1.03) 0.72 Lower BMI Schizophrenia Overall 498 MR Egger(Steiger filtering) 0.95 (0.90 to 1.01) 0.09 0.003 Lower BMI Schizophrenia Overall 498 MR-RAPS(Steiger filtering) 1.02 (1.01 to 1.03) 0.002 Lower BMI Schizophrenia Women 300 IVW 1.01 (0.98 to 1.04) 0.57 <0.001 Lower BMI Schizophrenia Women 300 Weighted median 0.98 (0.94 to 1.02) 0.25 Lower BMI Schizophrenia Women 300 MR Egger 0.90 (0.83 to 0.98) 0.01 0.003 Lower BMI Schizophrenia Women 300 MR-RAPS 1.01 (0.99 to 1.03) 0.23 Lower BMI Schizophrenia Women 297 IVW(Steiger filtering) 1.01 (0.98 to 1.04) 0.56 <0.001 Lower BMI Schizophrenia Women 297 Weighted median(Steiger filtering) 0.98 (0.94 to 1.02) 0.26 ### Page 61 Lower BMI Schizophrenia Women 297 MR Egger(Steiger filtering) 0.92 (0.85 to 0.99) 0.03 0.009 Lower BMI Schizophrenia Women 297 MR-RAPS(Steiger filtering) 1.01 (0.99 to 1.03) 0.26 Lower BMI Schizophrenia Men 252 IVW 1.01 (0.99 to 1.04) 0.39 <0.001 Lower BMI Schizophrenia Men 252 Weighted median 0.99 (0.96 to 1.02) 0.69 Lower BMI Schizophrenia Men 252 MR Egger 0.97 (0.90 to 1.04) 0.32 0.16 Lower BMI Schizophrenia Men 252 MR-RAPS 1.01 (0.99 to 1.02) 0.45 Lower BMI Schizophrenia Men 251 IVW(Steiger filtering) 1.01 (0.98 to 1.03) 0.5 <0.001 Lower BMI Schizophrenia Men 251 Weighted median(Steiger filtering) 0.99 (0.96 to 1.02) 0.69 Lower BMI Schizophrenia Men 251 MR Egger(Steiger filtering) 0.97 (0.91 to 1.04) 0.4 0.24 Lower BMI Schizophrenia Men 251 MR-RAPS(Steiger filtering) 1.01 (0.99 to 1.02) 0.51 Lower BMI Anorexia nervosa Overall 449 IVW 1.10 (1.07 to 1.12) <0.001 <0.001 Lower BMI Anorexia nervosa Overall 449 Weighted median 1.07 (1.03 to 1.11) <0.001 Lower BMI Anorexia nervosa Overall 449 MR Egger 1.02 (0.96 to 1.09) 0.54 0.03 Lower BMI Anorexia nervosa Overall 449 MR-RAPS 1.10 (1.08 to 1.12) <0.001 Lower BMI Anorexia nervosa Overall 448 IVW(Steiger filtering) 1.09 (1.06 to 1.12) <0.001 <0.001 Lower BMI Anorexia nervosa Overall 448 Weighted median(Steiger filtering) 1.07 (1.03 to 1.10) <0.001 Lower BMI Anorexia nervosa Overall 448 MR Egger(Steiger filtering) 1.02 (0.95 to 1.09) 0.6 0.02 Lower BMI Anorexia nervosa Overall 448 MR-RAPS(Steiger filtering) 1.10 (1.08 to 1.12) <0.001 ### Page 62 Lower BMI ADHD Overall 496 IVW 0.89 (0.87 to 0.90) <0.001 <0.001 Lower BMI ADHD Overall 496 Weighted median 0.90 (0.88 to 0.92) <0.001 Lower BMI ADHD Overall 496 MR Egger 0.95 (0.91 to 1.00) 0.04 0.001 Lower BMI ADHD Overall 496 MR-RAPS 0.89 (0.88 to 0.90) <0.001 Lower BMI ADHD Women 257 IVW 0.88 (0.85 to 0.92) <0.001 0.03 Lower BMI ADHD Women 257 Weighted median 0.91 (0.85 to 0.96) 0.001 Lower BMI ADHD Women 257 MR Egger 0.92 (0.81 to 1.04) 0.2 0.49 Lower BMI ADHD Women 257 MR-RAPS 0.89 (0.85 to 0.92) <0.001 Lower BMI ADHD Women 256 IVW(Steiger filtering) 0.89 (0.85 to 0.92) <0.001 0.12 Lower BMI ADHD Women 256 Weighted median(Steiger filtering) 0.91 (0.85 to 0.96) 0.001 Lower BMI ADHD Women 256 MR Egger(Steiger filtering) 0.92 (0.81 to 1.04) 0.16 0.58 Lower BMI ADHD Women 256 MR-RAPS(Steiger filtering) 0.89 (0.86 to 0.93) <0.001 Lower BMI ADHD Men 215 IVW 0.88 (0.86 to 0.91) <0.001 <0.001 Lower BMI ADHD Men 215 Weighted median 0.85 (0.82 to 0.89) <0.001 Lower BMI ADHD Men 215 MR Egger 0.89 (0.81 to 0.99) 0.03 0.84 Lower BMI ADHD Men 215 MR-RAPS 0.88 (0.85 to 0.90) <0.001 Lower BMI Autism spectrum disorder Overall 453 IVW 0.98 (0.95 to 1.00) 0.05 <0.001 Lower BMI Autism spectrum disorder Overall 453 Weighted median 0.98 (0.94 to 1.01) 0.17 Lower BMI Autism spectrum disorder Overall 453 MR Egger 0.98 (0.92 to 1.04) 0.51 0.9 Lower BMI Autism spectrum disorder Overall 453 MR-RAPS 0.97 (0.95 to 0.99) 0.002 Lower BMI Autism spectrum disorder Overall 450 IVW(Steiger filtering) 0.97 (0.95 to 0.99) 0.01 <0.001 Lower BMI Autism spectrum disorder Overall 450 Weighted median(Steiger filtering) 0.97 (0.94 to 1.01) 0.11 ### Page 63 Lower BMI Autism spectrum disorder Overall 450 MR Egger(Steiger filtering) 0.98 (0.93 to 1.04) 0.54 0.68 Lower BMI Autism spectrum disorder Overall 450 MR-RAPS(Steiger filtering) 0.97 (0.95 to 0.99) <0.001 Lower BMI Tourette syndrome Overall 451 IVW 0.97 (0.93 to 1.01) 0.14 <0.001 Lower BMI Tourette syndrome Overall 451 Weighted median 0.96 (0.90 to 1.03) 0.22 Lower BMI Tourette syndrome Overall 451 MR Egger 1.03 (0.93 to 1.15) 0.56 0.21 Lower BMI Tourette syndrome Overall 451 MR-RAPS 0.97 (0.93 to 1.00) 0.09 Lower BMI Tourette syndrome Overall 444 IVW(Steiger filtering) 0.98 (0.94 to 1.02) 0.28 <0.001 Lower BMI Tourette syndrome Overall 444 Weighted median(Steiger filtering) 0.96 (0.90 to 1.03) 0.24 Lower BMI Tourette syndrome Overall 444 MR Egger(Steiger filtering) 1.03 (0.93 to 1.14) 0.63 0.33 Lower BMI Tourette syndrome Overall 444 MR-RAPS(Steiger filtering) 0.97 (0.94 to 1.01) 0.14 Lower HbA1c Major depressive disorder Overall 282 IVW 1.00 (0.99 to 1.00) 0.14 <0.001 Lower HbA1c Major depressive disorder Overall 282 Weighted median 1.00 (0.99 to 1.00) 0.01 Lower HbA1c Major depressive disorder Overall 282 MR Egger 1.00 (0.99 to 1.00) 0.56 0.79 Lower HbA1c Major depressive disorder Overall 282 MR-RAPS 1.00 (0.99 to 1.00) 0.003 Lower HbA1c Major depressive disorder Women 185 IVW 1.00 (0.99 to 1.00) 0.27 <0.001 Lower HbA1c Major depressive disorder Women 185 Weighted median 1.00 (0.99 to 1.01) 0.94 Lower HbA1c Major depressive disorder Women 185 MR Egger 1.00 (0.99 to 1.01) 0.56 0.13 Lower HbA1c Major depressive disorder Women 185 MR-RAPS 1.00 (0.99 to 1.00) 0.13 Lower HbA1c Major depressive disorder Men 160 IVW 1.00 (0.99 to 1.01) 0.9 0.005 Lower HbA1c Major depressive disorder Men 160 Weighted median 1.00 (0.99 to 1.01) 0.5 Lower HbA1c Major depressive disorder Men 160 MR Egger 1.00 (0.99 to 1.01) 0.73 0.74 Lower HbA1c Major depressive disorder Men 160 MR-RAPS 1.00 (0.99 to 1.00) 0.87 ### Page 64 Lower HbA1c Post-partum depression Women 192 IVW 1.00 (0.99 to 1.01) 0.41 0.002 Lower HbA1c Post-partum depression Women 192 Weighted median 0.99 (0.98 to 1.01) 0.49 Lower HbA1c Post-partum depression Women 192 MR Egger 1.00 (0.98 to 1.02) 0.82 0.74 Lower HbA1c Post-partum depression Women 192 MR-RAPS 1.00 (0.99 to 1.01) 0.42 Lower HbA1c Bipolar disorder Overall 286 IVW 1.01 (0.99 to 1.02) 0.34 <0.001 Lower HbA1c Bipolar disorder Overall 286 Weighted median 1.00 (0.99 to 1.01) 0.54 Lower HbA1c Bipolar disorder Overall 286 MR Egger 0.99 (0.97 to 1.01) 0.17 0.02 Lower HbA1c Bipolar disorder Overall 286 MR-RAPS 1.00 (1.00 to 1.01) 0.6 Lower HbA1c Bipolar disorder I Overall 284 IVW 1.01 (1.00 to 1.02) 0.25 <0.001 Lower HbA1c Bipolar disorder I Overall 284 Weighted median 1.00 (0.99 to 1.02) 0.66 Lower HbA1c Bipolar disorder I Overall 284 MR Egger 0.99 (0.96 to 1.01) 0.18 0.02 Lower HbA1c Bipolar disorder I Overall 284 MR-RAPS 1.00 (1.00 to 1.01) 0.28 Lower HbA1c Bipolar disorder II Overall 283 IVW 1.00 (0.99 to 1.02) 0.86 0.002 Lower HbA1c Bipolar disorder II Overall 283 Weighted median 1.00 (0.97 to 1.02) 0.8 Lower HbA1c Bipolar disorder II Overall 283 MR Egger 0.97 (0.95 to 1.00) 0.06 0.02 Lower HbA1c Bipolar disorder II Overall 283 MR-RAPS 1.00 (0.99 to 1.02) 0.5 Lower HbA1c PTSD Overall 300 IVW 1.00 (0.99 to 1.01) 0.64 0.43 Lower HbA1c PTSD Overall 300 Weighted median 1.02 (1.00 to 1.03) 0.07 Lower HbA1c PTSD Overall 300 MR Egger 1.02 (1.01 to 1.04) 0.01 0.008 Lower HbA1c PTSD Overall 300 MR-RAPS 1.00 (0.99 to 1.02) 0.36 Lower HbA1c Schizophrenia Overall 287 IVW 1.00 (0.99 to 1.01) 0.45 <0.001 Lower HbA1c Schizophrenia Overall 287 Weighted median 1.00 (0.98 to 1.01) 0.37 Lower HbA1c Schizophrenia Overall 287 MR Egger 0.99 (0.97 to 1.01) 0.17 0.03 Lower HbA1c Schizophrenia Overall 287 MR-RAPS 1.00 (0.99 to 1.01) 0.95 Lower HbA1c Schizophrenia Overall 286 IVW(Steiger filtering) 1.00 (0.99 to 1.01) 0.53 <0.001 Lower HbA1c Schizophrenia Overall 286 Weighted median(Steiger filtering) 1.00 (0.98 to 1.01) 0.36 ### Page 65 Lower HbA1c Schizophrenia Overall 286 MR Egger(Steiger filtering) 0.99 (0.97 to 1.01) 0.23 0.06 Lower HbA1c Schizophrenia Overall 286 MR-RAPS(Steiger filtering) 1.00 (0.99 to 1.01) 1 Lower HbA1c Schizophrenia Women 184 IVW 0.99 (0.98 to 1.01) 0.3 <0.001 Lower HbA1c Schizophrenia Women 184 Weighted median 0.98 (0.97 to 1.00) 0.05 Lower HbA1c Schizophrenia Women 184 MR Egger 0.99 (0.97 to 1.01) 0.33 0.64 Lower HbA1c Schizophrenia Women 184 MR-RAPS 1.00 (0.99 to 1.00) 0.33 Lower HbA1c Schizophrenia Men 157 IVW 1.00 (0.99 to 1.01) 0.86 <0.001 Lower HbA1c Schizophrenia Men 157 Weighted median 1.00 (0.98 to 1.01) 0.46 Lower HbA1c Schizophrenia Men 157 MR Egger 0.99 (0.97 to 1.02) 0.59 0.45 Lower HbA1c Schizophrenia Men 157 MR-RAPS 1.00 (0.99 to 1.01) 0.8 Lower HbA1c Schizophrenia Men 156 IVW(Steiger filtering) 1.00 (0.99 to 1.01) 0.93 <0.001 Lower HbA1c Schizophrenia Men 156 Weighted median(Steiger filtering) 1.00 (0.98 to 1.01) 0.46 Lower HbA1c Schizophrenia Men 156 MR Egger(Steiger filtering) 1.00 (0.98 to 1.02) 0.72 0.71 Lower HbA1c Schizophrenia Men 156 MR-RAPS(Steiger filtering) 1.00 (0.99 to 1.01) 0.87 Lower HbA1c Anorexia nervosa Overall 246 IVW 1.02 (1.00 to 1.03) 0.02 <0.001 Lower HbA1c Anorexia nervosa Overall 246 Weighted median 1.01 (0.99 to 1.02) 0.53 Lower HbA1c Anorexia nervosa Overall 246 MR Egger 1.01 (0.99 to 1.03) 0.42 0.6 Lower HbA1c Anorexia nervosa Overall 246 MR-RAPS 1.02 (1.00 to 1.03) 0.005 Lower HbA1c ADHD Overall 270 IVW 0.99 (0.98 to 1.00) 0.02 <0.001 Lower HbA1c ADHD Overall 270 Weighted median 0.99 (0.98 to 1.01) 0.28 Lower HbA1c ADHD Overall 270 MR Egger 1.01 (0.99 to 1.02) 0.46 0.01 Lower HbA1c ADHD Overall 270 MR-RAPS 0.99 (0.98 to 1.00) 0.004 ### Page 66 Lower HbA1c ADHD Women 150 IVW 1.00 (0.98 to 1.02) 0.92 0.71 Lower HbA1c ADHD Women 150 Weighted median 1.01 (0.97 to 1.04) 0.75 Lower HbA1c ADHD Women 150 MR Egger 1.01 (0.98 to 1.04) 0.6 0.56 Lower HbA1c ADHD Women 150 MR-RAPS 1.00 (0.98 to 1.02) 0.8 Lower HbA1c ADHD Men 133 IVW 0.99 (0.97 to 1.00) 0.12 <0.001 Lower HbA1c ADHD Men 133 Weighted median 0.99 (0.96 to 1.01) 0.21 Lower HbA1c ADHD Men 133 MR Egger 0.99 (0.97 to 1.02) 0.63 0.66 Lower HbA1c ADHD Men 133 MR-RAPS 0.99 (0.98 to 1.00) 0.05 Lower HbA1c Autism spectrum disorder Overall 250 IVW 1.00 (0.99 to 1.02) 0.43 0.02 Lower HbA1c Autism spectrum disorder Overall 250 Weighted median 1.01 (1.00 to 1.03) 0.11 Lower HbA1c Autism spectrum disorder Overall 250 MR Egger 1.01 (0.99 to 1.03) 0.59 0.9 Lower HbA1c Autism spectrum disorder Overall 250 MR-RAPS 1.00 (0.99 to 1.02) 0.42 Lower HbA1c Autism spectrum disorder Overall 249 IVW(Steiger filtering) 1.00 (0.99 to 1.01) 0.57 0.19 Lower HbA1c Autism spectrum disorder Overall 249 Weighted median(Steiger filtering) 1.01 (1.00 to 1.03) 0.1 Lower HbA1c Autism spectrum disorder Overall 249 MR Egger(Steiger filtering) 1.01 (0.99 to 1.03) 0.52 0.69 Lower HbA1c Autism spectrum disorder Overall 249 MR-RAPS(Steiger filtering) 1.00 (0.99 to 1.01) 0.47 Lower HbA1c Tourette syndrome Overall 255 IVW 0.99 (0.97 to 1.01) 0.18 0.46 Lower HbA1c Tourette syndrome Overall 255 Weighted median 0.99 (0.96 to 1.02) 0.37 Lower HbA1c Tourette syndrome Overall 255 MR Egger 1.00 (0.97 to 1.04) 0.96 0.35 Lower HbA1c Tourette syndrome Overall 255 MR-RAPS 0.99 (0.97 to 1.01) 0.31 ADHD, attention deficit hyperactivity disorder; BMI, body mass index; HbA1c, glycated hemoglobin; IVW, inverse variance weighting; MR, Mendelian randomization;PTSD, post-traumatic stress disorder; RAPS, robust adjusted profile score. Estimates are presented as odds ratio per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease inHbA1c. ### Page 67 eTable 9. MR sensitivity analyses for the associations of lower BMI and lower HbA1c with the risk of substance use disorders. Exposure Outcome SNPs Method Estimate (95% CI) Measure P value P value(intercept) P value(Q) Lower BMI Substance use disorders 359 IVW -0.01 (-0.02 to -0.01) Beta <0.001 <0.001 Lower BMI Substance use disorders 359 Weighted median -0.01 (-0.02 to -0.01) Beta <0.001 Lower BMI Substance use disorders 359 MR Egger 0.003 (-0.01 to 0.02) Beta 0.70 0.02 Lower BMI Substance use disorders 359 MR-RAPS -0.01 (-0.02 to -0.01) Beta <0.001 Lower BMI Cannabis use disorder 453 IVW 0.94 (0.92 to 0.97) Odds ratio <0.001 <0.001 Lower BMI Cannabis use disorder 453 Weighted median 0.94 (0.90 to 0.98) Odds ratio 0.01 Lower BMI Cannabis use disorder 453 MR Egger 0.99 (0.92 to 1.06) Odds ratio 0.72 0.19 Lower BMI Cannabis use disorder 453 MR-RAPS 0.94 (0.92 to 0.97) Odds ratio <0.001 Lower BMI Alcohol dependence 452 IVW 0.99 (0.95 to 1.02) Odds ratio 0.35 0.14 Lower BMI Alcohol dependence 452 Weighted median 1.00 (0.95 to 1.06) Odds ratio 0.94 Lower BMI Alcohol dependence 452 MR Egger 1.04 (0.96 to 1.13) Odds ratio 0.34 0.15 Lower BMI Alcohol dependence 452 MR-RAPS 0.99 (0.96 to 1.02) Odds ratio 0.39 Lower BMI Alcohol dependence 451 IVW(Steiger filtering) 0.99 (0.96 to 1.02) Odds ratio 0.44 0.26 Lower BMI Alcohol dependence 451 Weighted median(Steiger filtering) 1.00 (0.95 to 1.06) Odds ratio 0.93 Lower BMI Alcohol dependence 451 MR Egger(Steiger filtering) 1.04 (0.96 to 1.13) Odds ratio 0.31 0.15 Lower BMI Alcohol dependence 451 MR-RAPS(Steiger filtering) 0.99 (0.96 to 1.02) Odds ratio 0.43 Lower BMI AUDIT (total score) 452 IVW 0.003 (0.001 to 0.01) Beta 0.01 <0.001 Lower BMI AUDIT (total score) 452 Weighted median 0.002 (-0.001 to 0.005) Beta 0.27 Lower BMI AUDIT (total score) 452 MR Egger 0.002 (-0.004 to 0.01) Beta 0.53 0.71 Lower BMI AUDIT (total score) 452 MR-RAPS 0.002 (0.001 to 0.004) Beta 0.01 ### Page 68 Lower BMI AUDIT (total score) 451 IVW(Steiger filtering) 0.003 (0.001 to 0.01) Beta 0.01 <0.001 Lower BMI AUDIT (total score) 451 Weighted median(Steiger filtering) 0.002 (-0.001 to 0.005) Beta 0.27 Lower BMI AUDIT (total score) 451 MR Egger(Steiger filtering) 0.001 (-0.004 to 0.01) Beta 0.63 0.54 Lower BMI AUDIT (total score) 451 MR-RAPS(Steiger filtering) 0.002 (0.001 to 0.004) Beta 0.01 Lower BMI AUDIT (alcohol consumption) 452 IVW 0.003 (0.001 to 0.01) Beta 0.001 <0.001 Lower BMI AUDIT (alcohol consumption) 452 Weighted median 0.002 (-0.001 to 0.01) Beta 0.15 Lower BMI AUDIT (alcohol consumption) 452 MR Egger 0.001 (-0.004 to 0.01) Beta 0.60 0.43 Lower BMI AUDIT (alcohol consumption) 452 MR-RAPS 0.003 (0.001 to 0.004) Beta <0.001 Lower BMI AUDIT (alcohol consumption) 451 IVW(Steiger filtering) 0.004 (0.002 to 0.01) Beta <0.001 <0.001 Lower BMI AUDIT (alcohol consumption) 451 Weighted median(Steiger filtering) 0.002 (-0.001 to 0.01) Beta 0.14 Lower BMI AUDIT (alcohol consumption) 451 MR Egger(Steiger filtering) 0.001 (-0.004 to 0.01) Beta 0.70 0.30 Lower BMI AUDIT (alcohol consumption) 451 MR-RAPS(Steiger filtering) 0.003 (0.001 to 0.004) Beta <0.001 Lower BMI AUDIT (alcohol problems) 452 IVW -0.001 (-0.003 to 0.001) Beta 0.16 <0.001 Lower BMI AUDIT (alcohol problems) 452 Weighted median 0.000 (-0.002 to 0.002) Beta 0.99 Lower BMI AUDIT (alcohol problems) 452 MR Egger 0.000 (-0.005 to 0.005) Beta 0.98 0.54 Lower BMI AUDIT (alcohol problems) 452 MR-RAPS -0.001 (-0.003 to 0.000) Beta 0.11 Lower BMI AUDIT (alcohol problems) 451 IVW(Steiger filtering) -0.001 (-0.003 to 0.001) Beta 0.20 <0.001 Lower BMI AUDIT (alcohol problems) 451 Weighted median(Steiger filtering) 0.000 (-0.002 to 0.002) Beta 0.99 ### Page 69 Lower BMI AUDIT (alcohol problems) 451 MR Egger(Steiger filtering) -0.000 (-0.005 to 0.004) Beta 0.91 0.67 Lower BMI AUDIT (alcohol problems) 451 MR-RAPS(Steiger filtering) -0.001 (-0.003 to 0.000) Beta 0.13 Lower HbA1c Substance use disorders 192 IVW -0.001 (-0.004 to 0.002) Beta 0.49 <0.001 Lower HbA1c Substance use disorders 192 Weighted median -0.000 (-0.003 to 0.003) Beta 0.83 Lower HbA1c Substance use disorders 192 MR Egger -0.000 (-0.01 to 0.005) Beta 0.87 0.80 Lower HbA1c Substance use disorders 192 MR-RAPS -0.001 (-0.003 to 0.001) Beta 0.23 Lower HbA1c Cannabis use disorder 253 IVW 0.99 (0.98 to 1.00) Odds ratio 0.17 0.02 Lower HbA1c Cannabis use disorder 253 Weighted median 0.99 (0.97 to 1.01) Odds ratio 0.27 Lower HbA1c Cannabis use disorder 253 MR Egger 1.00 (0.97 to 1.02) Odds ratio 0.92 0.45 Lower HbA1c Cannabis use disorder 253 MR-RAPS 0.99 (0.98 to 1.00) Odds ratio 0.08 Lower HbA1c Alcohol dependence 252 IVW 1.00 (0.98 to 1.02) Odds ratio 0.86 0.16 Lower HbA1c Alcohol dependence 252 Weighted median 1.01 (0.98 to 1.04) Odds ratio 0.69 Lower HbA1c Alcohol dependence 252 MR Egger 1.02 (0.98 to 1.05) Odds ratio 0.36 0.33 Lower HbA1c Alcohol dependence 252 MR-RAPS 1.00 (0.98 to 1.02) Odds ratio 0.90 Lower HbA1c AUDIT (total score) 262 IVW 0.001 (0.000 to 0.002) Beta 0.02 <0.001 Lower HbA1c AUDIT (total score) 262 Weighted median 0.000 (-0.001 to 0.002) Beta 0.62 Lower HbA1c AUDIT (total score) 262 MR Egger -0.001 (-0.003 to 0.001) Beta 0.44 0.01 Lower HbA1c AUDIT (total score) 262 MR-RAPS 0.001 (0.000 to 0.002) Beta 0.01 Lower HbA1c AUDIT (total score) 261 IVW(Steiger filtering) 0.001 (0.000 to 0.002) Beta 0.02 <0.001 Lower HbA1c AUDIT (total score) 261 Weighted median(Steiger filtering) 0.000 (-0.001 to 0.002) Beta 0.62 Lower HbA1c AUDIT (total score) 261 MR Egger(Steiger filtering) -0.001 (-0.002 to 0.001) Beta 0.59 0.03 Lower HbA1c AUDIT (total score) 261 MR-RAPS(Steiger filtering) 0.001 (0.000 to 0.002) Beta 0.01 ### Page 70 Lower HbA1c AUDIT (alcohol consumption) 262 IVW 0.001 (0.000 to 0.002) Beta 0.01 <0.001 Lower HbA1c AUDIT (alcohol consumption) 262 Weighted median 0.000 (-0.001 to 0.002) Beta 0.71 Lower HbA1c AUDIT (alcohol consumption) 262 MR Egger -0.001 (-0.002 to 0.001) Beta 0.50 0.01 Lower HbA1c AUDIT (alcohol consumption) 262 MR-RAPS 0.001 (0.000 to 0.002) Beta 0.001 Lower HbA1c AUDIT (alcohol consumption) 261 IVW(Steiger filtering) 0.001 (0.000 to 0.002) Beta 0.01 <0.001 Lower HbA1c AUDIT (alcohol consumption) 261 Weighted median(Steiger filtering) 0.000 (-0.001 to 0.002) Beta 0.71 Lower HbA1c AUDIT (alcohol consumption) 261 MR Egger(Steiger filtering) -0.000 (-0.002 to 0.001) Beta 0.65 0.02 Lower HbA1c AUDIT (alcohol consumption) 261 MR-RAPS(Steiger filtering) 0.001 (0.000 to 0.002) Beta 0.002 Lower HbA1c AUDIT (alcohol problems) 262 IVW 0.000 (-0.001 to 0.001) Beta 0.78 0.002 Lower HbA1c AUDIT (alcohol problems) 262 Weighted median -0.000 (-0.001 to 0.001) Beta 0.81 Lower HbA1c AUDIT (alcohol problems) 262 MR Egger -0.001 (-0.002 to 0.001) Beta 0.34 0.18 Lower HbA1c AUDIT (alcohol problems) 262 MR-RAPS 0.000 (-0.001 to 0.001) Beta 0.65 AUDIT, Alcohol Use Disorders Identification Test; BMI, body mass index; HbA1c, glycated hemoglobin; IVW, inverse variance weighting; MR, Mendelian randomization;RAPS, robust adjusted profile score. Positive associations with AUDIT scores indicate higher risk of alcohol use disorders. Estimates are presented per 1-kg/m2 decrease inBMI or per 1-mmol/mol decrease in HbA1c. ### Page 71 eFigure 6. IVW MR estimates for the associations of GLP-1R activation with mental health outcomes in comparison with those for lowerBMI and lower HbA1c in FinnGen. ADHD, attention deficit hyperactivity disorder; BMI, body mass index; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin; IVW, inverse varianceweighted; MR, Mendelian randomization; PTSD, post-traumatic stress disorder. Black squares denote genetically predicted (a) lower BMI or (b) lower HbA1c via GLP-1Ractivation based on variants within 1 Mb of GLP1R. White circles denote genetically predicted (a) lower BMI or (b) lower HbA1c based on genome-wide variants. Estimatesare presented as odds ratio per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease in HbA1c. ### Page 72 eTable 10. MR sensitivity analyses for the associations of lower BMI and lower HbA1c with mental health outcomes in FinnGen. Exposure Outcome SNPs Method Odds ratio (95% CI) P value P value(intercept) P value(Q) Lower BMI Major depressive disorder 500 IVW 0.99 (0.98 to 1.00) 0.15 <0.001 Lower BMI Major depressive disorder 500 Weighted median 1.00 (0.99 to 1.02) 0.85 Lower BMI Major depressive disorder 500 MR Egger 1.01 (0.97 to 1.04) 0.71 0.32 Lower BMI Major depressive disorder 500 MR-RAPS 1.00 (0.99 to 1.00) 0.39 Lower BMI Bipolar disorder 500 IVW 0.98 (0.96 to 1.01) 0.12 <0.001 Lower BMI Bipolar disorder 500 Weighted median 0.97 (0.94 to 1.01) 0.17 Lower BMI Bipolar disorder 500 MR Egger 0.99 (0.93 to 1.06) 0.76 0.77 Lower BMI Bipolar disorder 500 MR-RAPS 0.98 (0.96 to 1.01) 0.16 Lower BMI PTSD 500 IVW 0.96 (0.92 to 0.99) 0.009 0.008 Lower BMI PTSD 500 Weighted median 1.00 (0.95 to 1.06) 0.97 Lower BMI PTSD 500 MR Egger 1.07 (0.98 to 1.17) 0.12 0.006 Lower BMI PTSD 500 MR-RAPS 0.97 (0.93 to 1.00) 0.03 Lower BMI Schizophrenia 500 IVW 1.08 (1.04 to 1.12) <0.001 <0.001 Lower BMI Schizophrenia 500 Weighted median 1.10 (1.04 to 1.17) <0.001 Lower BMI Schizophrenia 500 MR Egger 1.02 (0.93 to 1.11) 0.74 0.17 Lower BMI Schizophrenia 500 MR-RAPS 1.09 (1.05 to 1.12) <0.001 Lower BMI Anorexia nervosa 500 IVW 1.03 (0.99 to 1.08) 0.09 0.001 Lower BMI Anorexia nervosa 500 Weighted median 1.05 (0.99 to 1.11) 0.12 Lower BMI Anorexia nervosa 500 MR Egger 1.08 (0.97 to 1.20) 0.16 0.4 Lower BMI Anorexia nervosa 500 MR-RAPS 1.03 (1.00 to 1.07) 0.08 Lower BMI ADHD 500 IVW 0.98 (0.95 to 1.01) 0.21 <0.001 Lower BMI ADHD 500 Weighted median 0.99 (0.94 to 1.05) 0.78 Lower BMI ADHD 500 MR Egger 0.98 (0.90 to 1.07) 0.62 0.97 Lower BMI ADHD 500 MR-RAPS 0.98 (0.96 to 1.01) 0.29 Lower BMI Substance abuse 500 IVW 0.99 (0.98 to 1.01) 0.48 <0.001 ### Page 73 Lower BMI Substance abuse 500 Weighted median 1.01 (0.99 to 1.04) 0.23 Lower BMI Substance abuse 500 MR Egger 1.08 (1.03 to 1.13) 0.002 <0.001 Lower BMI Substance abuse 500 MR-RAPS 1.00 (0.98 to 1.01) 0.45 Lower BMI Alcohol dependence 500 IVW 1.01 (0.99 to 1.04) 0.3 <0.001 Lower BMI Alcohol dependence 500 Weighted median 1.04 (1.01 to 1.08) 0.005 Lower BMI Alcohol dependence 500 MR Egger 1.09 (1.02 to 1.16) 0.008 0.01 Lower BMI Alcohol dependence 500 MR-RAPS 1.01 (1.00 to 1.03) 0.1 Lower HbA1c Major depressive disorder 291 IVW 1.00 (0.99 to 1.01) 0.92 <0.001 Lower HbA1c Major depressive disorder 291 Weighted median 1.00 (0.99 to 1.01) 0.52 Lower HbA1c Major depressive disorder 291 MR Egger 1.00 (0.99 to 1.01) 0.76 0.77 Lower HbA1c Major depressive disorder 291 MR-RAPS 1.00 (1.00 to 1.01) 0.67 Lower HbA1c Bipolar disorder 291 IVW 1.00 (0.99 to 1.02) 0.48 0.006 Lower HbA1c Bipolar disorder 291 Weighted median 1.01 (0.99 to 1.03) 0.17 Lower HbA1c Bipolar disorder 291 MR Egger 1.01 (0.99 to 1.03) 0.35 0.52 Lower HbA1c Bipolar disorder 291 MR-RAPS 1.00 (0.99 to 1.02) 0.43 Lower HbA1c PTSD 291 IVW 0.99 (0.98 to 1.01) 0.47 0.03 Lower HbA1c PTSD 291 Weighted median 0.99 (0.97 to 1.02) 0.63 Lower HbA1c PTSD 291 MR Egger 1.01 (0.97 to 1.04) 0.66 0.32 Lower HbA1c PTSD 291 MR-RAPS 0.99 (0.98 to 1.01) 0.51 Lower HbA1c Schizophrenia 291 IVW 1.00 (0.98 to 1.02) 0.93 0.01 Lower HbA1c Schizophrenia 291 Weighted median 0.99 (0.97 to 1.02) 0.68 Lower HbA1c Schizophrenia 291 MR Egger 0.99 (0.96 to 1.02) 0.5 0.45 Lower HbA1c Schizophrenia 291 MR-RAPS 1.00 (0.98 to 1.02) 0.88 Lower HbA1c Anorexia nervosa 291 IVW 1.02 (1.00 to 1.04) 0.08 0.04 Lower HbA1c Anorexia nervosa 291 Weighted median 1.02 (0.99 to 1.06) 0.17 Lower HbA1c Anorexia nervosa 291 MR Egger 1.01 (0.97 to 1.05) 0.53 0.71 Lower HbA1c Anorexia nervosa 291 MR-RAPS 1.02 (1.00 to 1.04) 0.09 Lower HbA1c ADHD 291 IVW 1.00 (0.99 to 1.02) 0.74 0.16 ### Page 74 Lower HbA1c ADHD 291 Weighted median 1.00 (0.98 to 1.03) 0.93 Lower HbA1c ADHD 291 MR Egger 1.01 (0.98 to 1.04) 0.61 0.69 Lower HbA1c ADHD 291 MR-RAPS 1.00 (0.99 to 1.02) 0.56 Lower HbA1c Substance abuse 291 IVW 1.00 (1.00 to 1.01) 0.45 <0.001 Lower HbA1c Substance abuse 291 Weighted median 1.00 (0.99 to 1.01) 0.75 Lower HbA1c Substance abuse 291 MR Egger 1.00 (0.99 to 1.02) 0.72 0.95 Lower HbA1c Substance abuse 291 MR-RAPS 1.00 (1.00 to 1.01) 0.44 Lower HbA1c Alcohol dependence 291 IVW 1.01 (1.00 to 1.02) 0.11 <0.001 Lower HbA1c Alcohol dependence 291 Weighted median 1.00 (0.99 to 1.02) 0.78 Lower HbA1c Alcohol dependence 291 MR Egger 1.00 (0.98 to 1.02) 0.74 0.15 Lower HbA1c Alcohol dependence 291 MR-RAPS 1.01 (1.00 to 1.02) 0.16 ADHD, attention deficit hyperactivity disorder; BMI, body mass index; HbA1c, glycated hemoglobin; IVW, inverse variance weighting; MR, Mendelian randomization;PTSD, post-traumatic stress disorder; RAPS, robust adjusted profile score. Estimates are presented as odds ratio per 1-kg/m2 decrease in BMI or per 1-mmol/mol decrease inHbA1c. ### Page 75 eTable 11. Wald estimates for the associations of lower HbA1c via GLP-1R activation (instrumented by rs10305492) with coronaryartery disease, all-cause mortality, and mental health outcomes. Category Outcome Sex Estimate (95% CI) Measure P value Cardiovascular andmortality outcome Coronary artery disease Overall 0.94 (0.85 to 1.04) Odds ratio 0.25 All-cause mortality Overall 0.96 (0.88 to 1.03) Hazard ratio 0.27 Mental healthdisorder Major depressive disorder Overall 1.04 (0.99 to 1.10) Odds ratio 0.13 Major depressive disorder Women 1.08 (0.92 to 1.27) Odds ratio 0.36 Major depressive disorder Men 0.97 (0.87 to 1.08) Odds ratio 0.59 Post-partum depression Women 0.98 (0.67 to 1.43) Odds ratio 0.93 Bipolar disorder Overall 1.01 (0.83 to 1.22) Odds ratio 0.92 Bipolar disorder I Overall 1.04 (0.79 to 1.37) Odds ratio 0.77 Bipolar disorder II Overall 1.19 (0.75 to 1.90) Odds ratio 0.46 PTSD Overall 1.32 (0.99 to 1.74) Odds ratio 0.05 Schizophrenia Overall 1.06 (0.88 to 1.28) Odds ratio 0.54 Schizophrenia Women 1.38 (0.88 to 2.17) Odds ratio 0.16 Schizophrenia Men 1.00 (0.83 to 1.21) Odds ratio 1.00 Anorexia nervosa Overall 1.07 (0.81 to 1.41) Odds ratio 0.65 ADHD Overall 0.98 (0.80 to 1.19) Odds ratio 0.83 ADHD Women 1.42 (0.68 to 2.95) Odds ratio 0.35 ADHD Men 0.90 (0.70 to 1.15) Odds ratio 0.39 Autism spectrum disorder Overall 1.21 (0.94 to 1.57) Odds ratio 0.14 Substance usedisorder Cannabis use disorder Overall 1.33 (0.93 to 1.91) Odds ratio 0.12 Alcohol dependence Overall 1.03 (0.43 to 2.47) Odds ratio 0.94 AUDIT (total score) Overall 0.01 (-0.02 to 0.03) Beta 0.60 AUDIT (alcoholconsumption) Overall 0.01 (-0.01 to 0.03) Beta 0.55 AUDIT (alcohol problems) Overall -0.004 (-0.02 to 0.02) Beta 0.70 Major depressive disorder Overall 0.99 (0.87 to 1.14) Odds ratio 0.93 ### Page 76 Replication outcome(FinnGen) Bipolar disorder Overall 0.95 (0.68 to 1.33) Odds ratio 0.76 PTSD Overall 1.03 (0.61 to 1.74) Odds ratio 0.90 Schizophrenia Overall 1.11 (0.67 to 1.86) Odds ratio 0.68 Anorexia nervosa Overall 0.86 (0.48 to 1.53) Odds ratio 0.60 ADHD Overall 0.79 (0.50 to 1.25) Odds ratio 0.31 Substance abuse Overall 0.91 (0.75 to 1.10) Odds ratio 0.32 Alcohol dependence Overall 0.97 (0.73 to 1.28) Odds ratio 0.80 ADHD, attention deficit hyperactivity disorder; AUDIT, Alcohol Use Disorders Identification Test; GLP-1R, glucagon-like peptide-1 receptor; HbA1c, glycated hemoglobin;PTSD, post-traumatic stress disorder. Estimates are presented per 1-mmol/mol decrease in HbA1c. rs10305492 was not available in the genome-wide association studies forthe well-being spectrum, Tourette syndrome, and substance use disorders. ### Page 77 eTable 12. The posterior probabilities of different hypotheses in pairwise colocalization analyses for BMI and each significant outcomewithin 1 Mb of the GLP1R gene. Outcome SNPs H0 H1 H2 H3 H4 Conditional H4 Well-being spectrum 2133 <0.1% 29.4% <0.1% 11.3% 59.3% 84.0% Life satisfaction 2133 <0.1% 13.4% <0.1% 12.9% 73.8% 85.2% Positive affect 2133 <0.1% 17.9% <0.1% 14.0% 68.1% 82.9% Neuroticism 2133 <0.1% 24.5% <0.1% 14.4% 61.1% 80.9% Depressive symptoms 2133 <0.1% 24.2% <0.1% 13.0% 62.7% 82.8% Major depressive disorder 2186 <0.1% <0.1% <0.1% 23.1% 76.9% 76.9% Bipolar disorder 2375 <0.1% 50.0% <0.1% 4.1% 45.9% 91.8% Bipolar disorder I 2336 <0.1% 60.7% <0.1% 4.5% 34.7% 88.5% BMI, body mass index. H0, no association with either trait; H1, association with BMI only; H2, association with outcome only; H3, associations of two independent variantsand one for each trait; H4, associations of one shared variant with both traits; conditional H4, associations of one shared variant with both traits conditional on the presence ofa variant associated with outcome (H4/(H2+H3+H4)).