# paper.pdf ## Metadata - PDFFormatVersion=1.7 - Language=en-US - IsLinearized=false - IsAcroFormPresent=false - IsXFAPresent=false - IsCollectionPresent=false - IsSignaturesPresent=false - Author=Collins, Jennifer E. - CreationDate=D:20260122044424Z - Creator=Microsoft® Word 2019 - ModDate=D:20260122044427Z - Producer=Adobe PDF Services - pdf:producer=Adobe PDF Services - dc:format=application/pdf - dc:creator=Collins, Jennifer E. - xmp:creatortool=Microsoft® Word 2019 - xmp:createdate=2026-01-22T04:44:24Z - xmp:modifydate=2026-01-22T04:44:27Z - xmp:metadatadate=2026-01-22T04:44:27Z - xmpmm:documentid=uuid:720F1BB6-B050-43D1-B387-A8FA5C417B64 - xmpmm:instanceid=uuid:be67907f-ac93-4dfc-b848-dbdadc7b9a6b ## Contents ### Page 1 A Retrospective, Real-Word Study of Intravenous Iron Use to Treat Iron-deficiencyAnemia During Acute Infection Haris Sohail 1, Jennifer E. Collins2, Kok Chan1, Mohammad Alamgir1, Amir Kamran1 1Charleston Area Medical Center, Hematology/Oncology Department, Charleston, WV 2Charleston Area Medical Center, Center for Health Services and Outcomes Research,Charleston, WV Supplemental ### Page 2 ### Page 3 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MI,myocardial infarction; MRSA, methicillin-resistant Staphylococcus aureus; PVD, peripheral vasculardisease; TIA, transient ischemic attack; UTI, urinary tract infection. ### Page 4 ### Page 5 ### Page 6 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MCV, meancorpuscular volume MI, myocardial infarction; MRSA, methicillin-resistant Staphylococcus aureus; PVD,peripheral vascular disease; TIA, transient ischemic attack. Reference ranges (typical adult values):hemoglobin ~12–17 g/dL; MCV 80–100 fL; albumin 3.5–5.0 g/dL; ferritin ~30–300 ng/mL (values <30ng/mL support iron deficiency); procalcitonin <0.05 ng/mL (values >0.50 ng/mL suggest bacterialinfection). ### Page 7 ### Page 8 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MCV, meancorpuscular volume MI, myocardial infarction; PVD, peripheral vascular disease; TIA, transient ischemicattack. Reference ranges (typical adult values): hemoglobin ~12–17 g/dL; MCV 80–100 fL; albumin 3.5–5.0 g/dL; ferritin ~30–300 ng/mL (values <30 ng/mL support iron deficiency); procalcitonin <0.05 ng/mL(values >0.50 ng/mL suggest bacterial infection). ### Page 9 ### Page 10 ### Page 11 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MCV, meancorpuscular volume MI, myocardial infarction; PVD, peripheral vascular disease; TIA, transient ischemicattack; UTI, urinary tract infection. Reference ranges (typical adult values): hemoglobin ~12–17 g/dL;MCV 80–100 fL; albumin 3.5–5.0 g/dL; ferritin ~30–300 ng/mL (values <30 ng/mL support iron deficiency);procalcitonin <0.05 ng/mL (values >0.50 ng/mL suggest bacterial infection). ### Page 12 ### Page 13 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MCV, meancorpuscular volume MI, myocardial infarction; PVD, peripheral vascular disease; TIA, transient ischemicattack. Reference ranges (typical adult values): hemoglobin ~12–17 g/dL; MCV 80–100 fL; albumin 3.5–5.0 g/dL; ferritin ~30–300 ng/mL (values <30 ng/mL support iron deficiency); procalcitonin <0.05 ng/mL(values >0.50 ng/mL suggest bacterial infection). ### Page 14 ### Page 15 CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IV, intravenous; MCV, meancorpuscular volume MI, myocardial infarction; PVD, peripheral vascular disease; TIA, transient ischemicattack. Reference ranges (typical adult values): hemoglobin ~12–17 g/dL; MCV 80–100 fL; albumin 3.5– ### Page 16 5.0 g/dL; ferritin ~30–300 ng/mL (values <30 ng/mL support iron deficiency); procalcitonin <0.05 ng/mL(values >0.50 ng/mL suggest bacterial infection). ### Page 17 ### Page 18 Supplemental Figure 1. Secondary outcomes by infection type and IV iron exposure. Box-and-whisker plots display mean values with standard deviations for (A) length of stay (LOS),(B) antibiotic days, (C) respirator days, and (D) transfusion days, stratified by infection type(MRSA Bacteremia, pneumonia, urinary tract infection, colitis, and cellulitis). Blue barsrepresent MRSA Bacteremia, red pneumonia, green UTI, purple colitis, and orange cellulitis.Values reflect the occurrence of these codes on or after the index date (defined as IDA +infection), meaning antibiotics given outside the hospital are not captured and changes inantibiotic regimen may not be counted. Asterisks indicate statistically significant differencesbetween IV iron and no–IV iron groups (ns = not significant, p < 0.05 = *, p < 0.01 = **, p <0.001 = ***, p < 0.0001 = ****). ### Page 19 Supplemental Figure 2. Change in hemoglobin by infection type and IV iron exposure. Bargraphs display mean change in hemoglobin (g/dL) from baseline (IDA + infection) to 60–90days post-index, stratified by infection type (MRSA/bacteremia, pneumonia, urinary tractinfection, colitis, and cellulitis). Asterisks denote significance levels between IV iron and no–IV iron groups (****p < 0.0001). ![A colorful lines on a black background AI-generated content may be incorrect.]()