2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T5c2,Data on the physiological impact of tracheal intubation and positive end-expiratory pressure (PEEP) on respiratory mechanics in anesthetized children are scarce. We aimed to evaluate the mechanical effects of intubation and PEEP in children without lung pathology under general anesthesia. Prospective physiologic experimental crossover study, in children under 15 years scheduled for elective surgery. After anesthesia induction and neuromuscular blockade, volume-controlled ventilation was initiated. Respiratory mechanics were assessed before (mask ventilation) and after tracheal intubation, at PEEP 0 and 5 cmH₂O. Measured variables included peak inspiratory (PIP), plateau (P 60 patients were included. Median age 58.0 (18.0-84.0) months. Intubation increased PIP-P PEEP and intubation induce changes in respiratory mechanics. While tracheal intubation increases PIP and ΔP, and decreases Crs, the addition of PEEP partially mitigates these effects on airway pressures, but not on MP. These results suggest a deterioration of both the resistive and elastic components during MV. This project was registered and approved for implementation by the Pediatric Hospital Center Pereira Rossell Institutional Review Board and registered in the Ministry of Public Health (#7647719). Informed and signed consent was obtained from all the children's parents or responsible guardians. All procedures in this study were performed in accordance with the Declaration of Helsinki.31:Tfb8,ABSTRACT Background Data on the physiological impact of tracheal intubation and positive end‐expiratory pressure (PEEP) on respiratory mechanics in anesthetized children are scarce. We aimed to evaluate the mechanical effects of intubation and PEEP in children without lung pathology under general anesthesia. Methods Prospective physiologic experimental crossover study, in children under 15 years scheduled for elective surgery. After anesthesia induction and neuromuscular blockade, volume‐controlled ventilation was initiated. Respiratory mechanics were assessed before (mask ventilation) and after tracheal intubation, at PEEP 0 and 5 cmH₂O. Measured variables included peak inspiratory (PIP), plateau (P PLAT ), and total expiratory pressures (tPEEP). Calculated parameters were compliance (Crs), driving pressure (ΔP), and mechanical power (MP). A mixed linear regression model was used. Results 60 patients were included. Median age 58.0 (18.0–84.0) months. Intubation increased PIP–P PLAT + 23.9% ( p < 0.001), Raw +16.4% ( p = 0.011), and ΔP + 20.4% ( p < 0.001); and decreased Crs –14% ( p = 0.001). PEEP during mask ventilation reduced ΔP 29.1% ( p < 0.001) and increased Crs 46.7% ( p < 0.001). Combined intubation and PEEP reduced ΔP (–7.9%, p = 0.002) and increased Crs (+19.6%, p < 0.001). PEEP raised MP both during mask ventilation (+50%) and after intubation (+83.3%, both p < 0.001). Children under 2 years showed higher Raw than older children across all conditions ( p < 0.001), but similar behavior in ΔP and Crs. Conclusion PEEP and intubation induce changes in respiratory mechanics. While tracheal intubation increases PIP and ΔP, and decreases Crs, the addition of PEEP partially mitigates these effects on airway pressures, but not on MP. These results suggest a deterioration of both the resistive and elastic components during MV. Trial Registration This project was registered and approved for implementation by the Pediatric Hospital Center Pereira Rossell Institutional Review Board and registered in the Ministry of Public Health (#7647719). Informed and signed consent was obtained from all the children's parents or responsible guardians. All procedures in this study were performed in accordance with the Declaration of Helsinki. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"child (1-12y): age group Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on child (1-12y) (age group). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/age_group/child%20(1-12y)\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Age Groups\",\"item\":\"https://www.reachrx.ai/hub/tag/age_group\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"child (1-12y)\",\"item\":\"https://www.reachrx.ai/hub/tag/age_group/child%20(1-12y)\"}]}}"}}]],["$","$L2f",null,{"title":"child (1-12y): Research & Clinical Takeaways","description":"Age-specific evidence for child (1-12y) — concise summaries and practical next steps.","papers":[{"doi":"10.1002/ppul.71468","pmid":"41532648","title":"Effects of Tracheal Intubation and PEEP on Respiratory Mechanics in Children Without Lung Injury Under General Anesthesia","journal_title":"Pediatric Pulmonology","journal_issn":"8755-6863","published_at":"2026-01-14T00:00:00.000Z","url":"https://doi.org/10.1002/ppul.71468","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1002/ppul.71468","days":"7","issn":"8755-6863","rank":"7","field":"Clinical Medicine","score":"3","category":"Respiratory System","categories":["Respiratory System"],"_categories":["Respiratory System"]},"pubmed":{"doi":"10.1002/ppul.71468","title":"Effects of Tracheal Intubation and PEEP on Respiratory Mechanics in Children Without Lung Injury Under General Anesthesia.","journal":"Pediatric pulmonology","methods":"","results":"60 patients were included. Median age 58.0 (18.0-84.0) months. Intubation increased PIP-P","abstract":"$30","keywords":["anesthesia","mechanical ventilation","pediatrics","positive end‐expiratory pressure","respiratory mechanics"],"pubmed_id":"41532648","conclusions":"PEEP and intubation induce changes in respiratory mechanics. While tracheal intubation increases PIP and ΔP, and decreases Crs, the addition of PEEP partially mitigates these effects on airway pressures, but not on MP. These results suggest a deterioration of both the resistive and elastic components during MV.","publication_date":"2026-01-14T00:00:00"},"crossref":{"DOI":"10.1002/ppul.71468","URL":"https://doi.org/10.1002/ppul.71468","ISSN":["8755-6863","1099-0496"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ppul.71468","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ppul.71468","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ppul.71468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Effects of Tracheal Intubation and PEEP on Respiratory Mechanics in Children Without Lung Injury Under General Anesthesia"],"author":[{"given":"Federico","family":"Cristiani","sequence":"first","affiliation":[{"name":"Departamento de Anestesiología Facultad de Medicina, Centro Hospitalario Pereira Rossell Universidad de la República Montevideo Uruguay"}]},{"given":"Anna","family":"Camporesi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesia and Intensive Care Vittore Buzzi Children's Hospital Milano Italy"}]},{"given":"Pablo","family":"Cruces","sequence":"additional","affiliation":[{"name":"Unidad de Paciente Crítico Pediátrico, Hospital El Carmen Dr. Luis Valentín Ferrada, Laboratory of Translational Research in Critical Care, Center for Research on Pandemic Resilience, Faculty of Life Sciences Universidad Andres Bello Santiago Chile"}]},{"given":"Bruno","family":"Suhr","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Milan Milan Italy"}]},{"given":"Isabella","family":"Fratti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Milan Milan Italy"}]},{"given":"Sebastián","family":"González‐Dambrauskas","sequence":"additional","affiliation":[{"name":"Departamento de Pediatría y Unidad de Cuidados Intensivos de Niños Facultad de Medicina, Centro Hospitalario Pereira Rossell Universidad de la República Montevideo Uruguay"}]}],"issued":{"date-parts":[[2026,1]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":"61","archive":["Portico"],"created":{"date-time":"2026-01-14T12:54:10Z","timestamp":1768395250000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-14T23:20:04Z","timestamp":1768432804356,"date-parts":[[2026,1,14]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":13,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1002/ppul.71468"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-08-28"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2026-01-06"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-14"}],"deposited":{"date-time":"2026-01-14T12:54:12Z","timestamp":1768395252000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"published":{"date-parts":[[2026,1]]},"publisher":"Wiley","reference":[{"DOI":"10.1007/s00134-013-2969-x","key":"e_1_2_13_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1365-2044.1976.tb11804.x","key":"e_1_2_13_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/BF01710652","key":"e_1_2_13_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/PCC.0000000000003291","key":"e_1_2_13_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/cc12500","key":"e_1_2_13_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/PCC.0000000000002780","key":"e_1_2_13_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5492/wjccm.v13.i1.88385","key":"e_1_2_13_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMsa1410639","key":"e_1_2_13_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/PCC.0000000000002848","key":"e_1_2_13_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s00134-016-4505-2","key":"e_1_2_13_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s13054-021-03853-6","key":"e_1_2_13_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/PCC.0000000000002186","key":"e_1_2_13_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s11517-022-02649-2","key":"e_1_2_13_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.299.6.646","key":"e_1_2_13_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5492/wjccm.v13.i3.96214","key":"e_1_2_13_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/pan.14366","key":"e_1_2_13_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s12871-018-0611-8","key":"e_1_2_13_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/00003246-200005000-00056","key":"e_1_2_13_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1126/scitranslmed.ado1097","key":"e_1_2_13_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1164/rccm.202310-1890LE","key":"e_1_2_13_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1152/japplphysiol.00734.2015","key":"e_1_2_13_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.bja.2022.06.037","key":"e_1_2_13_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.bja.2021.09.024","key":"e_1_2_13_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S2213-2600(16)00057-6","key":"e_1_2_13_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/ppul.27266","key":"e_1_2_13_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/ALN.0000000000004256","key":"e_1_2_13_27_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s00134-023-06991-3","key":"e_1_2_13_28_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/pan.14362","key":"e_1_2_13_29_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10439-017-1971-9","key":"e_1_2_13_30_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/pan.14362","key":"e_1_2_13_31_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/ppul.25169","key":"e_1_2_13_32_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/jcm11030557","key":"e_1_2_13_33_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1002/ppul.71468"],"article-number":"e71468","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"reference-count":32,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":32,"short-container-title":["Pediatric Pulmonology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1002/ppul.71468","is_oa":false,"title":"Effects of Tracheal Intubation and PEEP on Respiratory Mechanics in Children Without Lung Injury Under General Anesthesia","updated":"2026-01-16T01:10:40+00:00","published_date":"2026-01-01","best_oa_location":null}},"created_at":"2026-01-20T15:55:50.695Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1002/ppul.71468","tag_type":"age_group","value":"child (1-12y)","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"condition","value":"General Anesthesia","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"sample_size","value":"n=60","value_numeric":60},{"paper_doi":"10.1002/ppul.71468","tag_type":"study_design","value":"Crossover Study","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"warning","value":"Abstract text appears truncated; numeric effect sizes and the full list of measured variables are not available.","value_numeric":null},{"paper_doi":"10.1002/ppul.71468","tag_type":"warning","value":"Physiologic crossover design without stated randomization; design classification may not align with standard labels.","value_numeric":null}],"summaries":{"what_studied":"Prospective physiologic crossover study in 60 children (<15 years) without lung disease under general anesthesia, comparing mask ventilation versus post‑intubation ventilation at PEEP 0 and 5 cmH2O, measuring respiratory mechanics (PIP, ΔP, Crs, mechanical power).","key_result":"Tracheal intubation increased PIP and driving pressure (ΔP) and reduced respiratory system compliance (Crs); adding 5 cmH2O PEEP partly mitigated airway pressure increases but did not lower mechanical power.","practice_takeaway":"After intubation in healthy children under anesthesia, anticipate higher airway pressures and lower compliance; modest PEEP (5 cmH2O) can blunt pressure rises, but mechanical power may remain unchanged, indicating both resistive and elastic loads worsen with mechanical ventilation."}},{"doi":"10.1111/acem.70203","pmid":"41315052","title":"Nitrous Oxide for Treating Vaso‐Occlusive Crisis Pain in Children With Sickle Cell Disease: A Pilot Study","journal_title":"Academic Emergency Medicine","journal_issn":"1069-6563","published_at":"2025-11-29T00:00:00.000Z","url":"https://doi.org/10.1111/acem.70203","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-30","doi":"10.1111/acem.70203","days":"7","issn":"1069-6563","rank":"6","field":"Clinical Medicine","score":"2","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":{"doi":"10.1111/acem.70203","title":"Nitrous Oxide for Treating Vaso-Occlusive Crisis Pain in Children With Sickle Cell Disease: A Pilot Study.","journal":"Academic emergency medicine : official journal of the Society for Academic Emergency Medicine","methods":"","results":"","abstract":"","keywords":[],"pubmed_id":"41315052","conclusions":"","publication_date":"2025-11-29T00:00:00"},"crossref":{"DOI":"10.1111/acem.70203","URL":"https://doi.org/10.1111/acem.70203","ISSN":["1069-6563","1553-2712"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acem.70203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Nitrous Oxide for Treating Vaso‐Occlusive Crisis Pain in Children With Sickle Cell Disease: A Pilot Study"],"author":[{"given":"Daniel S.","family":"Tsze","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Division of Pediatric Emergency Medicine Columbia University Vagelos College of Physicians and Surgeons New York NY USA"}]},{"given":"Maureen","family":"Licursi","sequence":"additional","affiliation":[{"name":"NewYork‐Presbyterian Morgan Stanley Children's Hospital New York NY USA"},{"name":"Department of Pediatrics, Division of Pediatric Hematology, Oncology & Stem Cell Transplantation Columbia University Vagelos College of Physicians and Surgeons New York NY USA"}]},{"given":"Katherine L.","family":"Ender","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology, Oncology & Stem Cell Transplantation Columbia University Vagelos College of Physicians and Surgeons New York NY USA"}]},{"given":"Robert M.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Emergency Medicine Washington University in St. Louis School of Medicine St. Louis MO USA"}]},{"given":"Peter S.","family":"Dayan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Division of Pediatric Emergency Medicine Columbia University Vagelos College of Physicians and Surgeons New York NY USA"}]}],"issued":{"date-parts":[[2025,11,28]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2025-11-29T04:09:03Z","timestamp":1764389343000,"date-parts":[[2025,11,29]]},"indexed":{"date-time":"2025-11-29T04:30:49Z","timestamp":1764390649296,"date-parts":[[2025,11,29]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000,"date-parts":[[2025,11,28]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/acem.70203"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-11-12"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-11-19"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-11-28"}],"deposited":{"date-time":"2025-11-29T04:09:03Z","timestamp":1764389343000,"date-parts":[[2025,11,29]]},"issn-type":[{"type":"print","value":"1069-6563"},{"type":"electronic","value":"1553-2712"}],"published":{"date-parts":[[2025,11,28]]},"publisher":"Wiley","reference":[{"DOI":"10.3324/haematol.2013.086637","key":"e_1_2_7_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1182/blood-2015-05-647107","key":"e_1_2_7_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s13613-025-01479-3","key":"e_1_2_7_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/apa.12773","key":"e_1_2_7_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140-6736(96)91108-3","key":"e_1_2_7_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/00000542-200510000-00024","key":"e_1_2_7_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.4103/2045-9912.310058","key":"e_1_2_7_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1182/bloodadvances.2020001851","key":"e_1_2_7_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ymgmr.2020.100579","key":"e_1_2_7_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.annemergmed.2006.06.016","key":"e_1_2_7_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ajem.2019.03.013","key":"e_1_2_7_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/acem.70203"],"article-number":"acem.70203","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Academic Emergency Medicine"],"reference-count":11,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,11,28]]},"references-count":11,"short-container-title":["Academic Emergency Medicine"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/acem.70203","is_oa":true,"title":"Nitrous Oxide for Treating Vaso‐Occlusive Crisis Pain in Children With Sickle Cell Disease: A Pilot Study","updated":"2025-12-01T01:08:31+00:00","published_date":"2025-11-28","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.70203","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.70203","url_for_landing_page":"https://doi.org/10.1111/acem.70203"}}},"created_at":"2025-12-08T12:24:58.509Z","updated_at":"2025-12-08T12:24:58.509Z","tags":[{"paper_doi":"10.1111/acem.70203","tag_type":"age_group","value":"child (1-12y)","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"condition","value":"Sickle Cell Disease","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"generic","value":"nitrous oxide","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"modality","value":"Inhaled Analgesic","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"study_design","value":"Pilot Study","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"warning","value":"Age range unspecified beyond “children”; this may or may not include adolescents.","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"warning","value":"Design is labeled as a pilot, but specific methodology (randomized, controlled, observational) is not described.","value_numeric":null},{"paper_doi":"10.1111/acem.70203","tag_type":"warning","value":"Only title and metadata were available; no abstract, methods, or results were provided.","value_numeric":null}],"summaries":{"what_studied":"A pilot study evaluated nitrous oxide for treating vaso-occlusive crisis pain in children with sickle cell disease."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"age_group","value":"child (1-12y)"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Age Groups","href":"/hub/tag/age_group"},{"name":"child (1-12y)"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"age_group","hub_tag_value":"child (1-12y)"}}}]]

Papers