2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T61d,Cryolipolysis is an effective, well-tolerated noninvasive subcutaneous fat reduction treatment. Assess participant satisfaction, effectiveness, and safety of a dual-applicator cryolipolysis system that can deliver simultaneous treatments. Adult participants received treatment to the abdomen/flanks (midsection). Participants could also receive treatment to upper arms, thighs, and submental area. Primary end point was participant satisfaction with midsection results at 12 weeks after final treatment. Secondary end points included independent photography review, participant satisfaction with additional body areas, and overall satisfaction. Exploratory end points included 3D imaging of midsection volumetric changes and assessments at 4 weeks after initial treatment. Safety was monitored throughout. Of 110 treated participants, 75% were female. Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were "satisfied/very satisfied" with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects. The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety.31:T8b6, BACKGROUND Cryolipolysis is an effective, well-tolerated noninvasive subcutaneous fat reduction treatment. OBJECTIVE Assess participant satisfaction, effectiveness, and safety of a dual-applicator cryolipolysis system that can deliver simultaneous treatments. MATERIALS AND METHODS Adult participants received treatment to the abdomen/flanks (midsection). Participants could also receive treatment to upper arms, thighs, and submental area. Primary end point was participant satisfaction with midsection results at 12 weeks after final treatment. Secondary end points included independent photography review, participant satisfaction with additional body areas, and overall satisfaction. Exploratory end points included 3D imaging of midsection volumetric changes and assessments at 4 weeks after initial treatment. Safety was monitored throughout. RESULTS Of 110 treated participants, 75% were female. Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were “satisfied/very satisfied” with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects. CONCLUSION The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"CoolSculpting Elite: brand Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on CoolSculpting Elite (brand). Clinician-written summaries and actionable practice insights. 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Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were \"satisfied/very satisfied\" with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects.","abstract":"$30","keywords":[],"pubmed_id":"40929520","conclusions":"The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety.","publication_date":"2025-09-10T00:00:00"},"crossref":{"DOI":"10.1097/dss.0000000000004797","URL":"https://doi.org/10.1097/dss.0000000000004797","ISSN":["1076-0512","1524-4725"],"link":[{"URL":"https://journals.lww.com/10.1097/DSS.0000000000004797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study"],"author":[{"given":"Roy G.","family":"Geronemus","sequence":"first","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York, New York;"}]},{"given":"Jordan 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France;"}]},{"given":"Ulf","family":"Samuelson","sequence":"additional","affiliation":[{"name":"Akademikliniken, Stockholm, Sweden;"}]},{"given":"Terence","family":"Tan","sequence":"additional","affiliation":[{"name":"Halley Body Slimming Clinic, Singapore;"}]},{"given":"Maria","family":"Ali","sequence":"additional","affiliation":[{"name":"Peloton Advantage, LLC (an OPEN Health Company), Parsippany, New Jersey;"}]},{"given":"Meetu","family":"Bhogal","sequence":"additional","affiliation":[{"name":"AbbVie, Toronto, Ontario, Canada; and"}]},{"given":"Vaishali","family":"Patel","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]},{"given":"Hongyan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]},{"given":"Alda","family":"Karic","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]}],"issued":{"date-parts":[[2025,9,10]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":null,"created":{"date-time":"2025-09-10T19:01:46Z","timestamp":1757530906000,"date-parts":[[2025,9,10]]},"indexed":{"date-time":"2025-09-11T22:44:40Z","timestamp":1757630680603,"date-parts":[[2025,9,11]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","start":{"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000,"date-parts":[[2025,9,10]]},"delay-in-days":0,"content-version":"unspecified"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/DSS.0000000000004797"}},"subtitle":[],"deposited":{"date-time":"2025-09-10T19:01:48Z","timestamp":1757530908000,"date-parts":[[2025,9,10]]},"issn-type":[{"type":"print","value":"1076-0512"},{"type":"electronic","value":"1524-4725"}],"published":{"date-parts":[[2025,9,10]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":[{"DOI":"10.1097/01.DSS.0000452628.99209.4f","key":"R4-20250910","year":"2014","issue":null,"author":"Boey","volume":"40","first-page":"1004","unstructured":null,"article-title":"Fat reduction in the inner thigh using a prototype cryolipolysis applicator","journal-title":"Dermatol Surg","doi-asserted-by":"crossref"},{"DOI":"10.1002/lsm.22302","key":"R5-20250910","year":"2014","issue":null,"author":"Bernstein","volume":"46","first-page":"731","unstructured":null,"article-title":"Non-invasive fat reduction of the flanks using a new cryolipolysis applicator and overlapping, two-cycle treatments","journal-title":"Lasers Surg Med","doi-asserted-by":"crossref"},{"DOI":"10.1002/lsm.22207","key":"R6-20250910","year":"2014","issue":null,"author":"Garibyan","volume":"46","first-page":"75","unstructured":null,"article-title":"Three-dimensional volumetric quantification of fat loss following cryolipolysis","journal-title":"Lasers Surg 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results.","limitations":"Single‑arm, nonrandomized design without a control group; 3D volumetric assessments had large variability and potential positioning/clothing effects; free treatment and small samples for non‑midsection areas may bias satisfaction and limit generalizability.","practice_takeaway":"For adults seeking noninvasive midsection fat reduction, dual‑applicator cryolipolysis achieved high satisfaction at 12 weeks, with device‑related adverse effects in 4.5% (5/110), all mild and resolved. 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