2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T5df,Venous leg ulcers (VLUs) are traditionally managed with standard-of-care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comorbidities, conducting randomised controlled trials to evaluate the comparative efficacy of advanced treatment modalities is difficult, as many patients would likely be excluded. This retrospective, pragmatic, real-world evidence (RWE) study compared the healing outcomes of VLUs treated with either ovine forestomach matrix (OFM) (n = 312) or collagen/oxidised regenerated cellulose (ORC) (n = 239) in outpatient wound care centres. Unlike restrictive randomised controlled trials, minimal inclusion and exclusion criteria were applied to create two treatment cohorts that reflected the general VLU population. The incidence (%) of closure was greater in OFM-treated VLUs at 12, 24 and 36 weeks, and this difference was significant at 24 and 36 weeks compared to collagen/ORC. Median time to wound closure was significantly faster (p = 0.045) in the OFM cohort (11.1 ± 0.6 weeks) compared to the collagen/ORC group (12.3 ± 1.0 weeks). Cox proportional hazards analysis demonstrated that OFM-treated VLUs had a significantly greater probability of healing (up to ~40%). This RWE comparative efficacy study further substantiates the clinical benefit of OFM in the treatment of chronic wounds, such as VLU, in a real-world patient cohort.31:T66e,ABSTRACTVenous leg ulcers (VLUs) are traditionally managed with standard‐of‐care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comorbidities, conducting randomised controlled trials to evaluate the comparative efficacy of advanced treatment modalities is difficult, as many patients would likely be excluded. This retrospective, pragmatic, real‐world evidence (RWE) study compared the healing outcomes of VLUs treated with either ovine forestomach matrix (OFM) (n = 312) or collagen/oxidised regenerated cellulose (ORC) (n = 239) in outpatient wound care centres. Unlike restrictive randomised controlled trials, minimal inclusion and exclusion criteria were applied to create two treatment cohorts that reflected the general VLU population. The incidence (%) of closure was greater in OFM‐treated VLUs at 12, 24 and 36 weeks, and this difference was significant at 24 and 36 weeks compared to collagen/ORC. Median time to wound closure was significantly faster (p = 0.045) in the OFM cohort (11.1 ± 0.6 weeks) compared to the collagen/ORC group (12.3 ± 1.0 weeks). Cox proportional hazards analysis demonstrated that OFM‐treated VLUs had a significantly greater probability of healing (up to ~40%). This RWE comparative efficacy study further substantiates the clinical benefit of OFM in the treatment of chronic wounds, such as VLU, in a real‐world patient cohort.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Endoform Natural: brand Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Endoform Natural (brand). Clinician-written summaries and actionable practice insights. 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Study","updated":"2025-08-04T14:10:34+00:00","published_date":"2025-04-01","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.70368","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.70368","url_for_landing_page":"https://doi.org/10.1111/iwj.70368"}}},"created_at":"2025-09-19T21:56:38.497Z","updated_at":"2025-09-19T22:11:07.099Z","tags":[{"paper_doi":"10.1111/iwj.70368","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"brand","value":"Endoform Natural","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"brand","value":"Promogran","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"condition","value":"Venous Leg Ulcer","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"modality","value":"Collagen/ORC Dressing","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"modality","value":"Decellularized Extracellular Matrix","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"sample_size","value":"n=830 wounds","value_numeric":830},{"paper_doi":"10.1111/iwj.70368","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"warning","value":"Application frequency for collagen/ORC outside clinic visits was likely under-captured in records.","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"warning","value":"Groups differed in compression type and adjunctive skin substitute use; venous ablation data were unavailable.","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"warning","value":"Study funded by the device manufacturer with several author conflicts of interest.","value_numeric":null},{"paper_doi":"10.1111/iwj.70368","tag_type":"warning","value":"Unit of analysis is wounds, not patients; results may not directly translate to patient-level outcomes.","value_numeric":null}],"summaries":{"practice_takeaway":"In outpatient clinics using compression, OFM was associated with faster and more frequent VLU closure than collagen/ORC at 24–36 weeks. Consider OFM when selecting advanced matrices for VLUs, while interpreting results in light of observational design and potential confounding.","what_studied":"Retrospective real‑world analysis of venous leg ulcers in US outpatient wound centers (2014–2020), comparing ovine forestomach matrix (OFM) with collagen/oxidized regenerated cellulose (collagen/ORC) under compression. Outcomes were time to closure and incidence of closure at 12, 24, and 36 weeks across 830 VLUs (OFM n=470; collagen/ORC n=360) in 551 patients.","key_result":"Median time to closure was shorter with OFM vs collagen/ORC (11.1±0.6 vs 12.3±1.0 weeks; p=0.045); closure incidence was higher with OFM at 24 weeks (77.6% vs 69.2%; p=0.012) and 36 weeks (86.3% vs 79.7%; p=0.027). Adjusted Cox models showed greater probability of healing with OFM (HR 1.268 [95% CI 1.022–1.573] for ≥4 applications; HR 1.375 [1.011–1.869] for ≥8 applications), and the treatment effect persisted after further adjustment for compression type and skin substitute use (p=0.002).","limitations":"Nonrandomized, retrospective database study with imbalances in compression type and adjunctive skin substitute use between groups; key variables such as venous ablation were absent and debridement details were missing for many wounds; industry funding with multiple author conflicts of interest."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"brand","value":"Endoform Natural"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Brands","href":"/hub/tag/brand"},{"name":"Endoform Natural"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"brand","hub_tag_value":"Endoform Natural"}}}]]

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