2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T70b,The association between adenomyosis and uterine torsion, a rare, serious obstetric condition, remains unclear and has not been systematically investigated. This study aimed to elucidate the incidence, risk factors, and clinical characteristics of uterine torsion in pregnancies complicated by adenomyosis. We conducted a retrospective cohort study of women with adenomyosis undergoing cesarean section at The University of Tokyo Hospital from 2010 to 2023. Adenomyosis was diagnosed via magnetic resonance imaging and/or ultrasonography before and/or during early pregnancy. Uterine torsion was defined as > 45° rotation around the long uterine axis during cesarean section. We compared the clinical characteristics, adenomyotic features and surgical details of women with and without uterine torsion. Among 135 pregnant women with adenomyosis, 70 underwent cesarean section. Within this cesarean delivery cohort, uterine torsion was identified in six (8.6%) women. All torsion cases were asymptomatic and involved focal type adenomyosis; these six cases represented 13.6% (6/44) of the 44 women with focal type adenomyosis in this cesarean cohort. The torsion group required supraumbilical skin incisions (50.0% [3/6] vs. 0% [0/64], P < 0.001) and atypical uterine incisions (83.3% [5/6] vs. 23.4% [15/64], P = 0.006) significantly more often. This study highlights a high incidence (8.6%) of asymptomatic uterine torsion in a cohort of women with adenomyosis undergoing cesarean delivery. These findings suggest that focal adenomyosis may be a key risk factor and generate an important hypothesis that requires further investigation. Surgical planning should consider the possibility of uterine torsion, which may require tailored intraoperative strategies involving non-standard incisions.31:T806,Abstract The association between adenomyosis and uterine torsion, a rare, serious obstetric condition, remains unclear and has not been systematically investigated. This study aimed to elucidate the incidence, risk factors, and clinical characteristics of uterine torsion in pregnancies complicated by adenomyosis. We conducted a retrospective cohort study of women with adenomyosis undergoing cesarean section at The University of Tokyo Hospital from 2010 to 2023. Adenomyosis was diagnosed via magnetic resonance imaging and/or ultrasonography before and/or during early pregnancy. Uterine torsion was defined as > 45° rotation around the long uterine axis during cesarean section. We compared the clinical characteristics, adenomyotic features and surgical details of women with and without uterine torsion. Among 135 pregnant women with adenomyosis, 70 underwent cesarean section. Within this cesarean delivery cohort, uterine torsion was identified in six (8.6%) women. All torsion cases were asymptomatic and involved focal type adenomyosis; these six cases represented 13.6% (6/44) of the 44 women with focal type adenomyosis in this cesarean cohort. The torsion group required supraumbilical skin incisions (50.0% [3/6] vs. 0% [0/64], P < 0.001) and atypical uterine incisions (83.3% [5/6] vs. 23.4% [15/64], P = 0.006) significantly more often. This study highlights a high incidence (8.6%) of asymptomatic uterine torsion in a cohort of women with adenomyosis undergoing cesarean delivery. These findings suggest that focal adenomyosis may be a key risk factor and generate an important hypothesis that requires further investigation. Surgical planning should consider the possibility of uterine torsion, which may require tailored intraoperative strategies involving non-standard incisions. 32:T4f9,This systematic review and meta analysis was conducted to investigate the reproductive outcomes in the patients with adenomyosis after HIFU treatment, aimed to recommend HIFU treatment for those women with adenomyosis who have reproductive demand. Extensive search was performed through PubMed, EMBASE and Web of Science databases. All available studies that evaluated the reproductive outcomes after HIFU for adenomyosis. Systematic review was performed following PRISMA guidelines. A meta-analysis was performed on data from 15 studies involving 3730 patients with adenomyosis. Pooled results showed that the pregnancy rate (PR) in women who desired to conceive was 54.6%, the live-birth rate (LBR) based on pregnancy was 75.8%, and the possible prognostic factors were non-perfused volume (NPV%) and type of adenomyosis. This review suggests that HIFU was easier to operate, with less adverse events and noninferior to adenomyomectomy. Patients with higher non-perfused volume (NPV%) and focal or internal adenomyosis had more improvement in reproductive outcomes after HIFU treatment. However, the well-designed, prospective, randomized controlled trials (RCT) are needed to compare the reproductive outcomes in those adenomyosis patients after HIFU in the near future.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Adenomyosis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Adenomyosis (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Adenomyosis\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Adenomyosis\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Adenomyosis\"}]}}"}}]],["$","$L2f",null,{"title":"Adenomyosis: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Adenomyosis with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1093/humrep/deag101","pmid":"42381368","title":"Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the\n All of Us\n Research Program","journal_title":"Human Reproduction","journal_issn":"0268-1161","published_at":"2026-07-01T00:00:00.000Z","url":"https://doi.org/10.1093/humrep/deag101","source_score":45,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-18T13:39:50.366Z","updated_at":"2026-07-18T13:39:50.366Z","tags":[{"paper_doi":"10.1093/humrep/deag101","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"condition","value":"Adenomyosis","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"condition","value":"Endometriosis","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"modality","value":"Hormonal Contraceptive","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"sample_size","value":"n=22438","value_numeric":22438},{"paper_doi":"10.1093/humrep/deag101","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"study_design","value":"Cross-Sectional Cohort Study","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"warning","value":"Latent class analysis is a data-driven method; the four-class solution is a model choice and alternative class numbers could yield different phenotypes.","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"warning","value":"Several co-authors have significant financial conflicts of interest related to endometriosis diagnostics and therapeutics (equity, patents, consulting). Results should be interpreted with this in mind.","value_numeric":null},{"paper_doi":"10.1093/humrep/deag101","tag_type":"warning","value":"The 'practice_changing' impact flag reflects the study's novel identification of a psychological/neurological phenotype and call for broader screening, but findings are observational and not yet validated in independent cohorts.","value_numeric":null}],"summaries":{"what_studied":"Using latent class analysis (LCA) on 22,438 women with endometriosis from the All of Us Research Program (May 2018–October 2023), this study identified distinct symptom phenotypes and evaluated how class membership predicts quality of life (QoL), including a subgroup analysis of adenomyosis co-occurrence in premenopausal women aged 18–45.","key_result":"Four symptom phenotypes emerged: a 'High Pain & Gastrointestinal with Mood Symptoms' cluster, a 'Predominantly Psychological/Neurological' cluster, and milder groups. Women with adenomyosis clustered into two high-pain classes with no minimal-symptom group, signaling higher overall burden. Membership in the high-burden class was linked to lower general health scores, reduced social satisfaction, and greater barriers to healthcare access.","limitations":"Cross-sectional design prevents causal inference on QoL. Diagnosis mix (surgical, clinical, and self-reported) may introduce misclassification. The 'Minimal Symptom Burden' class may reflect EHR under-documentation rather than true low symptom burden, and the US-only sample limits generalizability.","practice_takeaway":"Clinicians should screen young women presenting with non-classical symptoms—anxiety, migraine, or depression—for endometriosis, as a distinct psychological/neurological phenotype exists that may delay diagnosis. Interdisciplinary management addressing mental health and GI symptoms alongside pelvic pain is warranted for high-burden patients."}},{"doi":"10.1093/humrep/deag084","pmid":"42204604","title":"Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study","journal_title":"Human Reproduction","journal_issn":"0268-1161","published_at":"2026-05-27T00:00:00.000Z","url":"https://doi.org/10.1093/humrep/deag084","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-06T13:22:53.389Z","updated_at":"2026-06-06T13:22:53.389Z","tags":[{"paper_doi":"10.1093/humrep/deag084","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"condition","value":"Adenomyosis","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"condition","value":"Endometriosis","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"condition","value":"Hypertensive Disorders of Pregnancy","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"condition","value":"Placenta Previa","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"condition","value":"Preterm Birth","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"modality","value":"Assisted Reproductive Technology","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"sample_size","value":"n=607","value_numeric":607},{"paper_doi":"10.1093/humrep/deag084","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"warning","value":"8.9% loss to follow-up may introduce selection bias if obstetric outcomes differed in the missing group.","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"warning","value":"Diagnosis was based solely on ultrasound (IDEA/MUSA criteria); superficial peritoneal endometriosis—detectable only surgically—was not captured, potentially underestimating disease burden.","value_numeric":null},{"paper_doi":"10.1093/humrep/deag084","tag_type":"warning","value":"The composite 'endometriosis and/or adenomyosis' group pools biologically distinct conditions; disease-specific risk estimates should be interpreted cautiously.","value_numeric":null}],"summaries":{"what_studied":"This prospective cohort study examined obstetric outcomes in 607 women who conceived via IVF/ICSI, comparing those with ultrasound-diagnosed endometriosis and/or adenomyosis (n=144, 23.7%) to disease-free women (n=463), using IDEA and revised MUSA criteria.","key_result":"Women with endometriosis and/or adenomyosis had significantly higher rates of preterm birth (18.9% vs 11.4%; aRR 1.63, 95% CI 1.06–2.49), driven by late preterm birth (16% vs 8%; aRR 2.56). They also faced elevated risk of placenta previa (9.0% vs 1.5%; aRR 5.82), antepartum hemorrhage (11.8% vs 6.5%; aRR 2.02), hypertensive disorders of pregnancy (13.2% vs 6.7%; aRR 2.26), and pelvic pain (16.7% vs 8.6%; aRR 1.91). Caesarean delivery, gestational diabetes, placental abruption, and postpartum hemorrhage were not significantly increased.","limitations":"- Study excludes women ≥40 years or BMI ≥30, limiting generalizability.\n- Superficial peritoneal endometriosis was not captured by ultrasound and not accounted for.\n- Underpowered for several secondary outcomes; the combined endometriosis/adenomyosis group is dominated by isolated endometriosis, potentially masking adenomyosis-specific effects.","practice_takeaway":"Clinicians should counsel women with ultrasound-diagnosed endometriosis and/or adenomyosis who conceive via IVF/ICSI about meaningfully higher risks of preterm birth, placenta previa, antepartum hemorrhage, and hypertensive disorders, and consider enhanced antenatal surveillance for these complications."}},{"doi":"10.1111/aogs.70223","pmid":"42136042","title":"Risks of gynecological and breast cancers in women with endometriosis or adenomyosis: A nationwide cohort study","journal_title":"Acta Obstetricia et Gynecologica Scandinavica","journal_issn":"0001-6349","published_at":"2026-05-14T00:00:00.000Z","url":"https://doi.org/10.1111/aogs.70223","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-28T13:24:24.008Z","updated_at":"2026-05-28T13:24:24.008Z","tags":[{"paper_doi":"10.1111/aogs.70223","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Adenomyosis","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Breast Cancer","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Cervical Cancer","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Endometrial Cancer","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Endometriosis","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"condition","value":"Ovarian Cancer","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"sample_size","value":"n=49133","value_numeric":49133},{"paper_doi":"10.1111/aogs.70223","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"study_design","value":"Nationwide Cohort Study","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"warning","value":"Endometriosis and adenomyosis were analyzed together as a combined exposure in most analyses; subgroup-specific risk estimates are limited.","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"warning","value":"The very high SIRs for endometrial and ovarian cancer in the same calendar year as diagnosis (47.0 and 39.6, respectively) likely reflect detection bias or concurrent diagnosis rather than true incidence elevation.","value_numeric":null},{"paper_doi":"10.1111/aogs.70223","tag_type":"warning","value":"Women with prior gynecological organ removal or mastectomy were not excluded, which may affect comparability with other studies.","value_numeric":null}],"summaries":{"what_studied":"This nationwide Swedish cohort study (1997–2018) examined the risks of gynecological and breast cancers in 49,133 women diagnosed with endometriosis or adenomyosis, compared to women without these conditions, using data from national registers.","key_result":"Women with endometriosis or adenomyosis had an overall SIR of 1.4 (95% CI 1.3–1.5) for gynecological and breast cancers. In subsequent calendar years, risks were elevated for ovarian cancer (SIR 1.9, 95% CI 1.6–2.2) and breast cancer (SIR 1.2, 95% CI 1.1–1.3), with especially high SIRs for ovarian clear cell (7.7), endometrioid (2.8), and low-grade serous (1.5) subtypes. Endometrial and cervical cancer risks were actually lower after the diagnosis year (SIRs 0.6 and 0.7, respectively).","limitations":"- Women with prior gynecological organ removal or mastectomy were not excluded, which may bias cancer incidence estimates downward for some cancers.\n- The study cannot fully separate endometriosis from adenomyosis as distinct exposures, limiting subgroup precision.\n- Observational design prevents causal inference; residual confounding from unmeasured variables is possible.","practice_takeaway":"Clinicians should be aware that women with endometriosis or adenomyosis carry a meaningfully higher subsequent risk of ovarian (especially clear cell and endometrioid subtypes) and breast cancers. This finding may support discussions about enhanced surveillance or prophylactic strategies in this population."}},{"doi":"10.1007/s43032-025-02045-9","pmid":"41507567","title":"An Unrecognized High Incidence of Asymptomatic Uterine Torsion in Pregnancies with Adenomyosis that Complicate Cesarean Delivery","journal_title":"Reproductive Sciences","journal_issn":"1933-7191","published_at":"2026-01-09T00:00:00.000Z","url":"https://doi.org/10.1007/s43032-025-02045-9","source_score":15,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-10","doi":"10.1007/s43032-025-02045-9","days":"7","issn":"1933-7191","rank":"2","field":"Clinical Medicine","score":"15","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1007/s43032-025-02045-9","title":"An Unrecognized High Incidence of Asymptomatic Uterine Torsion in Pregnancies with Adenomyosis that Complicate Cesarean Delivery.","journal":"Reproductive sciences (Thousand Oaks, Calif.)","methods":"","results":"","abstract":"$30","keywords":["Adenomyosis","Cesarean delivery","Focal type","Uterine torsion"],"pubmed_id":"41507567","conclusions":"","publication_date":"2026-01-09T00:00:00"},"crossref":{"DOI":"10.1007/s43032-025-02045-9","URL":"https://doi.org/10.1007/s43032-025-02045-9","ISSN":["1933-7191","1933-7205"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s43032-025-02045-9.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s43032-025-02045-9","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s43032-025-02045-9.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["An Unrecognized High Incidence of Asymptomatic Uterine Torsion in Pregnancies with Adenomyosis that Complicate Cesarean Delivery"],"author":[{"given":"Yuri","family":"Yoshida","sequence":"first","affiliation":[]},{"given":"Takayuki","family":"Iriyama","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Ariyoshi","sequence":"additional","affiliation":[]},{"given":"Haruka","family":"Matsui","sequence":"additional","affiliation":[]},{"given":"Kensuke","family":"Suzuki","sequence":"additional","affiliation":[]},{"given":"Ayako","family":"Hashimoto","sequence":"additional","affiliation":[]},{"given":"Mari","family":"Ichinose","sequence":"additional","affiliation":[]},{"given":"Masatake","family":"Toshimitsu","sequence":"additional","affiliation":[]},{"given":"Seisuke","family":"Sayama","sequence":"additional","affiliation":[]},{"given":"Takahiro","family":"Seyama","sequence":"additional","affiliation":[]},{"given":"Kenbun","family":"Sone","sequence":"additional","affiliation":[]},{"given":"Keiichi","family":"Kumasawa","sequence":"additional","affiliation":[]},{"given":"Osamu","family":"Wada-Hiraike","sequence":"additional","affiliation":[]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[]},{"given":"Yasushi","family":"Hirota","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100004721","id-type":"DOI","asserted-by":"crossref"}],"DOI":"10.13039/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref"}],"issued":{"date-parts":[[2026,1,8]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-01-08T17:37:40Z","timestamp":1767893860000,"date-parts":[[2026,1,8]]},"indexed":{"date-time":"2026-01-08T22:25:38Z","timestamp":1767911138734,"date-parts":[[2026,1,8]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000,"date-parts":[[2026,1,8]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000,"date-parts":[[2026,1,8]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s43032-025-02045-9"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"1 August 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"22 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"8 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"},"order":2,"value":"This retrospective cohort study was conducted with the approval of the Institutional Review Board of the University of Tokyo Hospital (Approval No. 3053-1). [cite: 60] All procedures were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"},"order":3,"value":"The study used an opt-out method to obtain patient consent, with information disclosed on the hospital website, as approved by the ethics committee. [cite: 61]"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":4,"value":"The authors report no conflict of interest."}],"deposited":{"date-time":"2026-01-08T17:37:41Z","timestamp":1767893861000,"date-parts":[[2026,1,8]]},"issn-type":[{"type":"print","value":"1933-7191"},{"type":"electronic","value":"1933-7205"}],"published":{"date-parts":[[2026,1,8]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1097/OGX.0000000000000767","key":"2045_CR1","year":"2020","issue":"4","author":"AM Ramseyer","volume":"75","first-page":"243","unstructured":"Ramseyer AM, Whittington JR, Resendez VA, Whitcombe DD, Magann EF. Torsion in the gravid and nongravid uterus: a review of the literature of an uncommon diagnosis. 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The torsion group more often required supraumbilical skin incisions (50.0% [3/6] vs 0% [0/64], P<0.001) and atypical uterine incisions (83.3% [5/6] vs 23.4% [15/64], P=0.006), with no significant differences in blood loss or operative time.","limitations":"Only six torsion cases limit precision; diagnosis was possible only at cesarean, introducing selection bias and restricting generalizability beyond cesarean deliveries; single-center retrospective design.","practice_takeaway":"In adenomyosis pregnancies—particularly focal type—anticipate asymptomatic uterine torsion at cesarean and prepare for non-standard approaches (e.g., vertical/supraumbilical skin and atypical uterine incisions). Use intraoperative ultrasonography to select a safe uterine incision site, as preoperative imaging did not detect torsion."}},{"doi":"10.1007/s43032-025-02031-1","pmid":"41491769","title":"Pregnancy Outcomes of Adenomyosis after Treatment with High-intensity Focused Ultrasound: a Systematic Review and Meta Analysis","journal_title":"Reproductive Sciences","journal_issn":"1933-7191","published_at":"2026-01-06T00:00:00.000Z","url":"https://doi.org/10.1007/s43032-025-02031-1","source_score":15,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-10","doi":"10.1007/s43032-025-02031-1","days":"7","issn":"1933-7191","rank":"9","field":"Clinical Medicine","score":"15","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1007/s43032-025-02031-1","title":"Pregnancy Outcomes of Adenomyosis after Treatment with High-intensity Focused Ultrasound: a Systematic Review and Meta Analysis.","journal":"Reproductive sciences (Thousand Oaks, Calif.)","methods":"","results":"","abstract":"$32","keywords":["Adenomyosis","Assisted reproductive technology","High-intensity focused ultrasound","Infertility","Pregnant outcomes"],"pubmed_id":"41491769","conclusions":"","publication_date":"2026-01-06T00:00:00"},"crossref":{"DOI":"10.1007/s43032-025-02031-1","URL":"https://doi.org/10.1007/s43032-025-02031-1","ISSN":["1933-7191","1933-7205"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s43032-025-02031-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s43032-025-02031-1","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s43032-025-02031-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Pregnancy Outcomes of Adenomyosis after Treatment with High-intensity Focused Ultrasound: a Systematic Review and Meta Analysis"],"author":[{"given":"Jiale","family":"Liang","sequence":"first","affiliation":[]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[]},{"given":"Guodong","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Yugui","family":"Cui","sequence":"additional","affiliation":[]},{"given":"Wenjun","family":"Cheng","sequence":"additional","affiliation":[]}],"funder":[{"name":"Jiangsu Center for Reproductive Medicine Innovation","award":["CXZX202207"],"award-info":[{"award-number":["CXZX202207"]}]}],"issued":{"date-parts":[[2026,1,5]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-01-05T17:21:12Z","timestamp":1767633672000,"date-parts":[[2026,1,5]]},"indexed":{"date-time":"2026-01-05T20:19:43Z","timestamp":1767644383898,"date-parts":[[2026,1,5]]},"license":[{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000,"date-parts":[[2026,1,5]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000,"date-parts":[[2026,1,5]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s43032-025-02031-1"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"10 February 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"29 November 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"5 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"},"order":2,"value":"The authors have no relevant financial or non-financial interests to disclose."}],"deposited":{"date-time":"2026-01-05T17:21:14Z","timestamp":1767633674000,"date-parts":[[2026,1,5]]},"issn-type":[{"type":"print","value":"1933-7191"},{"type":"electronic","value":"1933-7205"}],"published":{"date-parts":[[2026,1,5]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1016/j.bpobgyn.2006.01.016","key":"2031_CR1","year":"2006","issue":"4","author":"C Bergeron","volume":"20","first-page":"511","unstructured":"Bergeron C, Amant F, Ferenczy A. 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Higher non-perfused volume (NPV%) and focal or internal adenomyosis were associated with better outcomes; HIFU was described as easier to operate, with fewer adverse events, and noninferior to adenomyomectomy.","limitations":"No randomized controlled trials; comparative effectiveness and adverse event rates versus adenomyomectomy are not quantified in the abstract; live-birth rate is reported per pregnancy rather than per patient desiring conception.","practice_takeaway":"HIFU may be a fertility-preserving option for adenomyosis, with a pooled 54.6% pregnancy rate and a 75.8% live-birth rate among pregnancies; outcomes appear more favorable with higher NPV% and focal/internal disease. Use with caution given the predominantly nonrandomized evidence and the need for well-designed RCTs."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Adenomyosis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Adenomyosis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Adenomyosis"}}}]]

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