2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T41f,- **Dupilumab/eosinophilia in children**: ~20% of children on dupilumab had early eosinophil increases (≥500 cells/µL at Week 12), but this did not affect long-term efficacy or safety. - **Gene-microbiome/wheeze**: 17q12-21 SNPs (esp. Gasdermin B rs7216389TT) interacted with MSH airway microbiota to increase early-life wheeze risk; CDSB microbiota interactions were protective. - **miR-149/skin**: Loss of miR-149 worsened psoriasis-like and atopic dermatitis-like inflammation in mice; restoring miR-149 in human biopsies suppressed inflammatory markers. - **Sulfasalazine SCARs**: HLA-B\*38:02 (OR 11.69 for SJS/TEN), HLA-B\*39:01 (OR 24.78 for DRESS), and HLA-B\*13:01 (OR 7.00 for DRESS); a 4-allele panel had 84.8% sensitivity in Chinese populations. - **SERPING1 SP variants**: 6 of 33 signal peptide variants caused poor C1-INH synthesis; protein aggregates observed in ER for L10R, G17R, S22L. - **Tezepelumab remission (TERESA)**: 34.6% of patients achieved clinical remission at 52 weeks; 47.4% biologic-naive vs 20.0% biologic-experienced.31:T60f,Contact allergy to benzisothiazolinone (BIT) has increased in recent years, but exposure to it is not always found. It's important to know whether the gloves might be an isothiazolinone source especially in patients with symptoms from gloves and isothiazolinone contact allergy with or without allergy to rubber chemicals. To present results of chemical analysis of isothiazolinones in disposable rubber gloves of patients in an occupational dermatology clinic. We went through our chemical analysis record from 2018-2025 and identified isothiazolinone analyses done from disposable rubber gloves. The chemical analysis of glove extracts was done by liquid chromatography-mass spectrometry (LC-MS). We screened the respective patients' files and collected information on their occupation, glove usage, patch test reactions as well as basic information on their hand eczema. We discovered BIT in 30/54 (60%) analysed gloves (27 nitrile rubber gloves, 2 neoprene rubber gloves and 1 natural rubber glove) in concentrations of 0.3-73.7 ppm (mean 12.7 ppm, median 4.2 ppm). Methylisothiazolinone (MI) was found in solitary gloves in small concentrations. Isothiazolinone-containing gloves were samples from altogether 21 patients, and six of them had several gloves that contained isothiazolinones. Many patients had also other isothiazolinone sources at work or at home. Disposable rubber gloves are a possible BIT source. Several gloves contained BIT in a concentration that may be enough to induce contact allergy when gloves are used frequently.32:T92e,ABSTRACT Background Contact allergy to benzisothiazolinone (BIT) has increased in recent years, but exposure to it is not always found. It's important to know whether the gloves might be an isothiazolinone source especially in patients with symptoms from gloves and isothiazolinone contact allergy with or without allergy to rubber chemicals. Objectives To present results of chemical analysis of isothiazolinones in disposable rubber gloves of patients in an occupational dermatology clinic. Methods We went through our chemical analysis record from 2018–2025 and identified isothiazolinone analyses done from disposable rubber gloves. The chemical analysis of glove extracts was done by liquid chromatography‐mass spectrometry (LC–MS). We screened the respective patients' files and collected information on their occupation, glove usage, patch test reactions as well as basic information on their hand eczema. Results We discovered BIT in 30/54 (60%) analysed gloves (27 nitrile rubber gloves, 2 neoprene rubber gloves and 1 natural rubber glove) in concentrations of 0.3–73.7 ppm (mean 12.7 ppm, median 4.2 ppm). Methylisothiazolinone (MI) was found in solitary gloves in small concentrations. Isothiazolinone‐containing gloves were samples from altogether 21 patients, and six of them had several gloves that contained isothiazolinones. Many patients had also other isothiazolinone sources at work or at home. Conclusions Disposable rubber gloves are a possible BIT source. Several gloves contained BIT in a concentration that may be enough to induce contact allergy when gloves are used frequently. 33:T4fa,Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries. To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group. Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children. A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions. Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.34:T8c8,ABSTRACTBackgroundContact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.ObjectivesTo collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.Materials and MethodsData from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0–16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut‐off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.ResultsA total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol‐21‐pivalate was included despite its lower frequency due to its difficult‐to‐suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L‐101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.ConclusionResults from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.35:T590,The skin microbiome plays an important role in health and disease. We have recently shown that microbes living on the skin regulate the immunomodulatory properties of UVR, but the underlying mechanisms remain to be uncovered. Using a preclinical model of immunosuppression against the chemical allergen 2,4-dinitrofluorobenzene, 16S microbiome sequencing, in vitro cultures, high-performance liquid chromatography-mass spectrometry and the generation of gnotobiotic-like mice, we report that acute UVB radiation induces a transient and significant restructuring of bacterial communities on the skin through one of its major photoproducts, cis-urocanic acid. Certain bacteria, such as Staphylococcus epidermidis, use urocanase (HutU) to metabolize cis-urocanic acid to proliferate. This in turn affects the concentration of cis-urocanic acid on the skin, limiting its ability to suppress adaptive immune responses and induce tolerance to 2,4-dinitrofluorobenzene. Interestingly, addition of a topical urocanase inhibitor restricts the metabolism of cis-urocanic acid by HutU+ bacteria and restores immunosuppression. Overall, these results illustrate how, by harnessing a unique nutrient produced in response to UVR, urocanase-positive skin-resident bacteria can fine tune immune responses to environmental antigens. They should open new avenues to enhance the beneficial effects of phototherapy protocols and sun protection.36:T556,As both allergic contact dermatitis and atopic dermatitis (AD) have similar clinical presentations and are characterized by spongiotic dermatitis on skin biopsy, many children with AD are not referred for patch testing and allergic contact dermatitis is underdiagnosed. To provide updated prevalence data of common contact allergens in children with and without AD. This is a retrospective case-control study using the Pediatric Allergic Contact Dermatitis Registry from 2018 to 2022. A total of 912 children were included (615 with AD and 297 without AD). Children with AD were more likely to have a longer history of dermatitis (4.1 vs 1.6 years, P < .0001), have seen more providers (2.3 vs 2.1, P = .003), have greater than 1 positive patch test (PPT) result (P = .005), have a greater number of PPT results overall (2.3 vs 1.9, P = .012), and have a more generalized distribution of dermatitis (P = .001). PPT to bacitracin (P = .030), carba mix (P = .025), and cocamidopropyl betaine (P = .0007) were significantly increased in children with AD compared to those without AD. Technical variation between providers and potential for misclassification, selection, and recall biases. Children with AD are significantly more likely to have PPT reactions and should be referred for evaluation of allergic contact dermatitis and obtain patch testing.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Allergic Contact Dermatitis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Allergic Contact Dermatitis (condition). Clinician-written summaries and actionable practice insights. 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No content could be extracted for summaries or tags. The entry appears to be an 'Editors' Choice' editorial/collection notice rather than an original research article — the actual study content is not included.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.07.012","tag_type":"warning","value":"The sulfasalazine HLA genetic findings are derived exclusively from Asian populations (Taiwan, China, Japan, Malaysia, Thailand); applicability to non-Asian populations is not established.","value_numeric":null},{"paper_doi":"10.1016/j.jaci.2026.07.012","tag_type":"warning","value":"This is an editors' summary article covering 6 distinct studies — tags and summaries reflect highlights across all studies, not a single primary investigation.","value_numeric":null}],"summaries":{"what_studied":"This editors' choice issue summarizes 6 studies covering: dupilumab in children with asthma and transient eosinophilia (VOYAGE/EXCURSION trials, ages 6–11, ≤1 year + extension); gene-microbiome interactions and childhood wheeze; miR-149 as a skin inflammation regulator; HLA genetic markers for sulfasalazine-induced SCARs; SERPING1 signal peptide variants in HAE; and tezepelumab clinical remission in severe asthma (TERESA, n=107, 52 weeks).","key_result":"$30","limitations":"This is an editors' summary of multiple studies, not a single primary paper; individual study limitations (post hoc design for dupilumab analysis, single-arm phase 4 for TERESA, Asian-only cohorts for sulfasalazine genetics) apply to each respective article and are not fully detailed here.","practice_takeaway":"In children on dupilumab for asthma, an isolated early rise in eosinophils alone is unlikely to require stopping treatment. For sulfasalazine prescribing in Asian patients, preemptive HLA screening (especially B\\*38:02, B\\*39:01, B\\*13:01) can identify those at high risk for life-threatening skin reactions before starting therapy."}},{"doi":"10.1093/bjd/ljag086.340","pmid":null,"title":"CD15 What is in the soap? Contact allergen prevalence in UK supermarkets and NHS liquid hand soaps","journal_title":"British Journal of Dermatology","journal_issn":"0007-0963","published_at":"2026-06-26T00:00:00.000Z","url":"https://doi.org/10.1093/bjd/ljag086.340","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-07-02T13:33:23.040Z","updated_at":"2026-07-02T13:33:23.040Z","tags":[{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"condition","value":"Allergic Contact Dermatitis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"condition","value":"Irritant Contact Dermatitis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"condition","value":"Occupational Dermatitis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"benzoic acid","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"cinnamal","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"citronellol","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"cocamidopropyl betaine","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"linalool","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"methylisothiazolinone","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"generic","value":"phenoxyethanol","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"modality","value":"Topical Skin Cleanser","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"sample_size","value":"n=145","value_numeric":145},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"study_design","value":"Cross-Sectional Survey","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"warning","value":"Allergen presence was determined by label review only; no patch testing or concentration data were collected, so clinical relevance of individual exposures cannot be directly inferred.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"warning","value":"Sample size (n=145) reflects product count, not patient count — this is a product ingredient survey, not a clinical study. No sex or age data are applicable.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljag086.340","tag_type":"warning","value":"Study design is described as a cross-sectional ingredient survey; 'Cross-Sectional Survey' is the closest standard label but the paper does not use this term explicitly.","value_numeric":null}],"summaries":{"what_studied":"Ingredient lists of 119 supermarket and 26 NHS liquid hand soaps in the UK were screened for recognized contact allergens using the BSCA and Chemotechnique allergen series, comparing allergen prevalence between retail and healthcare settings.","key_result":"Cocamidopropyl betaine was the most common allergen across all products (76%). Supermarket soaps had higher rates of fragrance allergens (e.g., parfum, linalool, citronellol, cinnamal); NHS soaps had higher rates of preservatives (e.g., phenoxyethanol, benzoic acid, methylisothiazolinone). Fragrance allergens appeared in 33% of NHS products; methylisothiazolinone was still present in 15% of NHS products. Multiple allergens co-occurred in many products across both settings.","limitations":"Ingredient label analysis only — actual allergen concentrations were not measured. Data reflect a single point in time and may not capture product reformulations. Only three supermarket chains and the NHS supply chain were included, limiting generalizability.","practice_takeaway":"When counselling patients with contact dermatitis — especially healthcare workers — check whether their hand soap contains cocamidopropyl betaine, methylisothiazolinone, or fragrance components, as these remain widespread in both retail and NHS products. Clinicians involved in NHS procurement should be aware that methylisothiazolinone persists in 15% of NHS handwash products despite known sensitization risks."}},{"doi":"10.2340/actadv.v106.adv-2026-0340","pmid":"42343576","title":"Aspects of Adverse Effects of Cosmetic Products: An Invited Narrative Review","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-06-24T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2026-0340","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-28T13:27:22.631Z","updated_at":"2026-06-28T13:27:22.631Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Allergic Contact Dermatitis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Contact Dermatitis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Irritant Contact Dermatitis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Occupational Skin Disease","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Photosensitivity Reaction","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"condition","value":"Respiratory Sensitization","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"2-hydroxyethyl methacrylate","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"benzalkonium chloride","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"benzophenone-3","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"methylisothiazolinone","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"octocrylene","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"para-phenylenediamine","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"sodium lauryl sulfate","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"generic","value":"tretinoin","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"Acrylate Nail System","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"Cosmetic Product","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"Fragrance","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"Preservative","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"Retinoid","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"modality","value":"UV Filter / Sunscreen","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"warning","value":"No sample size tag applied — the review synthesizes multiple studies with varying N; no single pooled population size is reported.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"warning","value":"Some cited prevalence figures (e.g., 1–5% CD in general population) are derived from a Chinese pharmacovigilance dataset, which may not generalize globally.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"warning","value":"The 'confirms_prior' impact flag was chosen because the review largely validates established allergen hierarchies; no single practice-changing finding is introduced.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0340","tag_type":"warning","value":"This is a narrative, non-systematic review; evidence quality varies widely across cited studies (case reports to cohort studies), and findings should be interpreted with that heterogeneity in mind.","value_numeric":null}],"summaries":{"what_studied":"This narrative review synthesized published evidence (case reports, case series, clinical trials, and epidemiological studies identified via PubMed) on the spectrum of adverse effects linked to cosmetic product use, covering contact dermatitis, respiratory sensitization, photosensitization, workplace exposures, paediatric risks, and pregnancy/lactation concerns.","key_result":"Contact dermatitis (CD) is the most frequent adverse effect, accounting for ~84% of cosmetic reactions and affecting 1–5% of the general population; rates of CD to personal care products rose more than 2.7-fold from 1996 to 2016. Key allergens include fragrances (limonene, linalool), preservatives (MI with 4.5% sensitization rate), and acrylates (HEMA responsible for up to 97% of acrylate contact allergy). Sunscreen agents caused nearly 90% of positive photopatch tests in North America (2009–2020). Endocrine-disrupting chemicals (parabens, phthalates, UV filters) cross the placenta and are linked to low birth weight and neurodevelopmental delay.","limitations":"- Narrative (non-systematic) review with non-exhaustive literature search, introducing selection bias.\n- Long-term and cumulative exposure health impacts remain poorly characterized across all adverse effect categories.\n- Causative attribution is often unclear (e.g., only 20.1% of positive cobalt reactions could be linked to a source).","practice_takeaway":"Clinicians should maintain a low threshold for extended patch testing—including hydroperoxides of limonene and linalool—when standard screening is equivocal, as 38% of fragrance positives can be missed without targeted testing. Pregnant patients and children should be counseled to minimize cosmetic exposure, especially to parabens, phthalates, and UV filters during the first trimester."}},{"doi":"10.1111/cod.70087","pmid":"41540775","title":"Isothiazolinones in Disposable Rubber Gloves—Results of Chemical Analysis","journal_title":"Contact Dermatitis","journal_issn":"0105-1873","published_at":"2026-01-16T00:00:00.000Z","url":"https://doi.org/10.1111/cod.70087","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-18","doi":"10.1111/cod.70087","days":"7","issn":"0105-1873","rank":"10","field":"Clinical Medicine","score":"1","category":"Allergy","categories":["Allergy"],"_categories":["Allergy"]},"pubmed":{"doi":"10.1111/cod.70087","title":"Isothiazolinones in Disposable Rubber Gloves-Results of Chemical Analysis.","journal":"Contact dermatitis","methods":"","results":"We discovered BIT in 30/54 (60%) analysed gloves (27 nitrile rubber gloves, 2 neoprene rubber gloves and 1 natural rubber glove) in concentrations of 0.3-73.7 ppm (mean 12.7 ppm, median 4.2 ppm). Methylisothiazolinone (MI) was found in solitary gloves in small concentrations. Isothiazolinone-containing gloves were samples from altogether 21 patients, and six of them had several gloves that contained isothiazolinones. Many patients had also other isothiazolinone sources at work or at home.","abstract":"$31","keywords":["BIT","CMI/MI","MI","OIT","benzisothiazolinone","chloromethylisothiazolinone/methylisothiazolinone","hand dermatitis","methylisothiazolinone","octylisothiazolionone","preservative"],"pubmed_id":"41540775","conclusions":"","publication_date":"2026-01-16T00:00:00"},"crossref":{"DOI":"10.1111/cod.70087","URL":"https://doi.org/10.1111/cod.70087","ISSN":["0105-1873","1600-0536"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cod.70087","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cod.70087","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cod.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Isothiazolinones in Disposable Rubber Gloves—Results of Chemical Analysis"],"author":[{"given":"Katri","family":"Suuronen","sequence":"first","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}]},{"given":"Katriina","family":"Ylinen","sequence":"additional","affiliation":[{"name":"Work Environment Services Finnish Institute of Occupational Health Helsinki Finland"}]},{"given":"Sari","family":"Suomela","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}]},{"given":"Maria","family":"Pesonen","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}]}],"issued":{"date-parts":[[2026,1,15]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2026-01-16T07:05:57Z","timestamp":1768547157000,"date-parts":[[2026,1,16]]},"indexed":{"date-time":"2026-01-16T19:07:15Z","timestamp":1768590435108,"date-parts":[[2026,1,16]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/cod.70087"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication 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USGP Code of Federal Regulations (US): 21 CFR § 177.2600—Rubber Articles Intended for Repeated Use 2023 https://www.govinfo.gov/app/details/CFR‐2023‐title21‐vol3/CFR‐2023‐title21‐vol3‐sec177‐2600/summary.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1111/j.1600-0536.2007.01278.x","key":"e_1_2_11_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/archderm.142.10.1326","key":"e_1_2_11_12_1","year":"2006","issue":"10","author":"Aalto‐Korte K.","volume":"142","first-page":"1326","unstructured":null,"article-title":"Antimicrobial Allergy From Polyvinyl Chloride Gloves","journal-title":"Archives of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1089/derm.2023.0150","key":"e_1_2_11_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/cod.14173","key":"e_1_2_11_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/cod.14357","key":"e_1_2_11_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_11_16_1","year":"2020","issue":null,"author":"Krautheim A.","volume":null,"first-page":"551","unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1007/978-3-030-36335-2_87","key":"e_1_2_11_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/cod.14508","key":"e_1_2_11_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/cod.70087"],"article-number":"cod.70087","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Contact Dermatitis"],"reference-count":17,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,15]]},"references-count":17,"short-container-title":["Contact Dermatitis"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/cod.70087","is_oa":true,"title":"Isothiazolinones in Disposable Rubber Gloves—Results of Chemical Analysis","updated":"2026-01-18T01:04:10+00:00","published_date":"2026-01-15","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cod.70087","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cod.70087","url_for_landing_page":"https://doi.org/10.1111/cod.70087"}}},"created_at":"2026-01-20T15:55:50.695Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1111/cod.70087","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"condition","value":"Allergic Contact Dermatitis","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"sample_size","value":"n=54","value_numeric":54},{"paper_doi":"10.1111/cod.70087","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"warning","value":"Findings may not generalize to all glove brands or settings, and other isothiazolinone exposures were common.","value_numeric":null},{"paper_doi":"10.1111/cod.70087","tag_type":"warning","value":"Study design classification is approximate; this is a lab analysis of patient-provided gloves from a dermatology clinic.","value_numeric":null}],"summaries":{"what_studied":"A retrospective review (2018–2025) of LC–MS chemical analyses of disposable rubber gloves submitted by patients from an occupational dermatology clinic, with linked chart data on occupation, glove use, patch tests, and hand eczema.","key_result":"Benzisothiazolinone (BIT) was detected in 30/54 gloves (60%)—27 nitrile, 2 neoprene, 1 natural rubber—at 0.3–73.7 ppm (mean 12.7, median 4.2). Methylisothiazolinone (MI) appeared only in isolated gloves at low levels; isothiazolinone‑containing gloves were from 21 patients, with 6 patients submitting multiple positive gloves.","limitations":"Clinic-based, retrospective sampling of patient gloves limits generalizability. Many patients had other isothiazolinone sources, complicating attribution of symptoms to gloves.","practice_takeaway":"Disposable rubber gloves can be a source of BIT, sometimes at levels that may induce contact allergy with frequent use. In patients with glove-related symptoms or known BIT allergy, consider gloves as a potential exposure source."}},{"doi":"10.1111/cod.70033","pmid":"40973997","title":"Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series","journal_title":"Contact Dermatitis","journal_issn":"0105-1873","published_at":"2025-09-20T00:00:00.000Z","url":"https://doi.org/10.1111/cod.70033","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-09-22","doi":"10.1111/cod.70033","days":"14","issn":"0105-1873","rank":"9","field":"Clinical Medicine","score":"7","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/cod.70033","title":"Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.","journal":"Contact dermatitis","methods":"","results":"A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.","abstract":"$33","keywords":["baseline series","children","contact allergens","patch testing"],"pubmed_id":"40973997","conclusions":"Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.","publication_date":"2025-09-20T00:00:00"},"crossref":{"DOI":"10.1111/cod.70033","URL":"https://doi.org/10.1111/cod.70033","ISSN":["0105-1873","1600-0536"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cod.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series"],"author":[{"given":"Anne Birgitte","family":"Simonsen","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Allergy, Skin and Venerology, Gentofte Hospital, Gentofte Hospitalsvej 20A, Hellerup University of Copenhagen, Institute of Clinical Medicine Denmark Copenhagen Denmark"}]},{"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology‐Allergology and Occupational Dermatology Amsterdam University Medical Center Amsterdam the Netherlands"}]},{"given":"Suzana Ljubojevicé","family":"Hadzavdic","sequence":"additional","affiliation":[{"name":"University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine University of Zagreb Zagreb Croatia"}]},{"given":"Radoslaw","family":"Spiewak","sequence":"additional","affiliation":[{"name":"Department of Experimental Dermatology and Cosmetology Jagiellonian University Medical College Krakow Poland"}]},{"given":"Anna Belloni","family":"Fortina","sequence":"additional","affiliation":[{"name":"Paediatric Dermatology Regional Center, Department of Woman's and Child's Health SDB University of Padua Padua Italy"}]},{"given":"Margarida","family":"Gonçalo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra Coimbra Portugal"}]},{"given":"Ana Maria Giménez","family":"Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute, Universitat Pompeu Fabra Barcelona Spain"}]},{"given":"Nidia","family":"Planella‐Fontanillas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute, Universitat Pompeu Fabra Barcelona Spain"}]},{"given":"Marie L. A.","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen Groningen the Netherlands"}]},{"given":"Heinrich","family":"Dickel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology St. Josef Hospital, University Medical Center, Ruhr University Bochum Bochum Germany"}]},{"given":"Jonathan","family":"White","sequence":"additional","affiliation":[{"name":"Ecole de Sante Publique, Université Libre de Bruxelles Belgium"}]},{"given":"Györgyi","family":"Pónyai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Dermato‐Oncology Semmelweis University Budapest Hungary"}]},{"given":"S. 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hierarchies.","value_numeric":null},{"paper_doi":"10.1016/j.jid.2025.03.035","tag_type":"warning","value":"Sample size and quantitative outcomes were not provided.","value_numeric":null}],"summaries":{"what_studied":"In a mouse model of UVB-induced immunosuppression to the chemical allergen 2,4-dinitrofluorobenzene, the investigators tested whether the UV photoproduct cis-urocanic acid reshapes skin bacteria and alters immune tolerance, using 16S sequencing, in vitro culture, LC-MS, and gnotobiotic-like mice. They also evaluated whether a topical urocanase inhibitor blocks bacterial metabolism of cis-urocanic acid.","key_result":"Acute UVB caused a transient restructuring of skin microbiota via cis-urocanic acid; Staphylococcus epidermidis and other HutU+ bacteria metabolized cis-urocanic acid, proliferated, and lowered its levels, which reduced UVR’s suppression of adaptive immunity and tolerance to 2,4-dinitrofluorobenzene. Topical inhibition of urocanase curtailed this metabolism and restored immunosuppression.","limitations":"Preclinical mouse model under gnotobiotic-like conditions; no human data or clinical outcomes. Sample size and effect magnitudes were not reported in the abstract.","practice_takeaway":"This is mechanistic, preclinical evidence: the skin microbiome can blunt UV-induced immunosuppression, and blocking bacterial urocanase restored it in mice. Clinicians should view this as hypothesis-generating; human studies are needed before considering microbiome- or urocanase-targeted approaches to influence phototherapy responses."}},{"doi":"10.1016/j.jaad.2023.06.048","pmid":"37768237","title":"Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective case-control study","journal_title":"Journal of the American Academy of Dermatology","journal_issn":"0190-9622","published_at":"2023-09-28T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaad.2023.06.048","source_score":484,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2023-09-30","doi":"10.1016/j.jaad.2023.06.048","days":"30","issn":"0190-9622","rank":"3","field":"Clinical Medicine","score":"484","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1016/j.jaad.2023.06.048","title":"Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective case-control study.","journal":"Journal of the American Academy of Dermatology","methods":"","results":"A total of 912 children were included (615 with AD and 297 without AD). Children with AD were more likely to have a longer history of dermatitis (4.1 vs 1.6 years, P < .0001), have seen more providers (2.3 vs 2.1, P = .003), have greater than 1 positive patch test (PPT) result (P = .005), have a greater number of PPT results overall (2.3 vs 1.9, P = .012), and have a more generalized distribution of dermatitis (P = .001). PPT to bacitracin (P = .030), carba mix (P = .025), and cocamidopropyl betaine (P = .0007) were significantly increased in children with AD compared to those without AD.","abstract":"$36","keywords":["allergic contact dermatitis","atopic dermatitis","children","patch testing","pediatric"],"pubmed_id":"37768237","conclusions":"Children with AD are significantly more likely to have PPT reactions and should be referred for evaluation of allergic contact dermatitis and obtain patch 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classification may be approximate.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2023.06.048","tag_type":"warning","value":"Details on age distribution and sex were not provided in the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2023.06.048","tag_type":"warning","value":"The abstract reports P values and some means but not absolute event counts or rates for allergen-specific positives.","value_numeric":null}],"summaries":{"what_studied":"A multicenter retrospective case-control analysis of the Pediatric Allergic Contact Dermatitis Registry (2018–2022) comparing contact allergen patch test results in 912 children, 615 with atopic dermatitis (AD) and 297 without AD.","key_result":"Children with AD had more than 1 positive patch test (P=0.005), a higher mean number of positive tests overall (2.3 vs 1.9; P=0.012), longer dermatitis duration (4.1 vs 1.6 years; P<.0001), and more generalized dermatitis (P=0.001). Positive patch tests to bacitracin (P=0.030), carba mix (P=0.025), and cocamidopropyl betaine (P=0.0007) were more frequent in AD than non-AD children.","limitations":"Retrospective registry design with technical variation between providers and potential misclassification, selection, and recall biases.","practice_takeaway":"In children with AD, consider referral for allergic contact dermatitis evaluation and patch testing, as they show higher rates of positive patch tests and sensitization to specific allergens."}}],"initialOffset":7,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Allergic Contact Dermatitis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Allergic Contact Dermatitis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Allergic Contact Dermatitis"}}}]]

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