Atopic Dermatitis: Research & Clinical Takeaways

Assessed AI chatbots’ advice for atopic dermatitis for accuracy, readability, and concordance with AAD guidelines.

A set of 356 DNB genes showed temporal fluctuations that identified a pre-disease state before AD-like dermatitis onset; these genes were enriched in...

In routine care for children under 12 with moderate-to-severe atopic dermatitis, dupilumab was associated with greater improvements in signs and itch...

Expect accelerated epigenetic aging in psoriatic arthritis, while psoriasis alone may not; signals are also seen in pediatric atopic dermatitis and...

For infants, starting daily full‑body emollient before 9 weeks reduced physician‑diagnosed AD by about 7 percentage points by 24 months versus no...

Track flare burden. More frequent, longer, and more severe flares align with worse quality of life and predict more severe AD the next year,...

For adults with atopic dermatitis, anticipate higher visit burden during temperature extremes and when PM10 and SO2 are elevated; reducing exposure...

Dupilumab was associated with a higher relative risk of new-onset psoriasis vs other systemic agents in adults with AD, but the absolute excess risk...

In visits with youths with moderate‑to‑severe AD, address itch and sleep broadly, and ask adolescents about anxiety, embarrassment, and peer impact....

TSW appears mechanistically distinct from atopic dermatitis with a complex I/NAD+ signature; any use of metformin or berberine for TSW should be...

In toddlers with mild-to-moderate atopic dermatitis, once-daily roflumilast 0.05% improved signs and itch by Week 4—and as early as 24 hours—while...

An AI-enabled wearable with haptic feedback reduced nocturnal scratching over one week in adults with mild atopic dermatitis without shortening...

Patients who self-identify TSW report substantial morbidity (itch, sleep loss, mood symptoms) and often believe steroids trigger it; clinicians...

For adults with atopic dermatitis, a brief self-guided online CBT program was noninferior to clinician-guided CBT on POEM and required minimal...

In adolescents with moderate to severe atopic dermatitis, upadacitinib 15–30 mg daily sustained high EASI-75 responses through 76 weeks, with safety...

A cross-sectional analysis in the All of Us Research Program examining the association between atopic dermatitis and peripheral vascular disease.

In children, higher BMI and weight gain are associated with greater AD risk, while weight loss from overweight to normal weight is associated with...

In routine care, dupilumab sustained long-term control across age groups, and many patients could space dosing to every 3–4 weeks. About one-quarter...

Higher estimated sodium intake was associated with greater odds of AD diagnosis, activity, and severity. Discuss sodium intake with patients as a...

Cross-sectional analysis of 2014–2018 National Health Interview Survey data examining whether parental e‑cigarette use is associated with atopic...

Do not rely solely on physician-rated severity or visibility to gauge impact. Routinely identify stigmatization and bullying and track change with...

Expect few or no before–after images in AD RCT manuscripts; consider providing your own visual aids when counseling patients about expected outcomes.

Patients’ and caregivers’ views on how atopic dermatitis symptoms relate to mental health.

Prioritize evaluation for learning and memory difficulties in children with AD who also have neurodevelopmental conditions such as ADHD or learning...

Fewer than 60% of patients starting systemic immunomodulators received recommended baseline tests. Clinicians should verify TB and hepatitis...

For dermatology patients, short-term systemic JAK/TYK2 inhibitor use did not increase MACE or VTE versus placebo over a median 16 weeks. This...

Once-daily topical PF-07038124 0.01% outperformed vehicle at 6 weeks in mild to moderate AD and plaque psoriasis. TEAEs were similar to vehicle (AD:...

During wildfire-driven air pollution spikes, clinicians should anticipate more AD/dermatitis flares and counsel vulnerable patients on exposure...

Paradoxical eczema was rare in biologic-treated psoriasis, with the lowest observed risk on IL‑23 inhibitors. Screen for personal history of atopic...

In dermatology RCTs, JAK inhibitors did not increase short-term risk of MACE, death, or VTE vs controls. Use routine cardiovascular/VTE risk...

Dupilumab can trigger a benign, reversible lymphoid reaction that mimics CTCL in adults with atopic dermatitis; recognizing its distinctive...

In children with AD, consider referral for allergic contact dermatitis evaluation and patch testing, as they show higher rates of positive patch...

Expect higher IBD risk—especially Crohn’s—in patients with AD, with risk increasing as AD severity worsens; in severe AD, the elevation is...

Systemic immune signatures in atopic dermatitis are age-specific beyond shared Th2 activation; consider patient age when interpreting blood...

For adults with AD, prioritize moisturizers and appropriate TCS or TCIs, with topical PDE‑4 or JAK inhibitors as options. Use bathing and wet wraps...

For adolescents and adults with moderate-to-severe atopic dermatitis, adding lebrikizumab to low- to mid-potency topical steroids for 16 weeks...

For adult atopic dermatitis, prioritize moisturizers and guideline-supported topicals (corticosteroids, calcineurin inhibitors, PDE-4 and JAK...

For caregivers of children with atopic dermatitis—especially mothers—screen for stress and suicidal ideation and address quality-of-life concerns, as...

In routine practice, upadacitinib improved AD signs/symptoms and concomitant hand eczema by 16 weeks with no new safety signals. Use these data as...

No change in clinical practice. These preclinical data support continued clinical testing of oral orismilast as a selective PDE4 inhibitor with broad...