2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T447,This predefined subgroup included 3655 patients (1849 in the evolocumab group and 1806 in the placebo group) with a median age of 65 years (57% female). Among those in the lipid substudy, the median LDL-C level at 48 weeks was 52 mg/dL in the evolocumab group vs 111 mg/dL in the placebo group (P < .001). A 3-P MACE event occurred in 83 patients (5-year Kaplan-Meier estimate, 5.0%) in the evolocumab group compared with 117 patients (5-year Kaplan-Meier estimate, 7.1%) in the placebo group (hazard ratio [HR], 0.69 [95% CI, 0.52-0.91]; P = .009; between-group difference, 2.1% [95% CI, 0.4%-3.8%]). A 4-P MACE event occurred in 127 patients (5-year Kaplan-Meier estimate, 7.6%) in the evolocumab group compared with 178 patients (5-year Kaplan-Meier estimate, 10.5%) in the placebo group (HR, 0.69 [95% CI, 0.55-0.86]; P = .001; between-group difference, 2.9% [95% CI, 0.9%-4.9%]). There were 136 deaths (5-year Kaplan-Meier estimate, 7.8%) in the evolocumab group compared with 172 deaths (5-year Kaplan-Meier estimate, 10.1%) in the placebo group (HR, 0.76 [95% CI, 0.61-0.95]).31:Taee,Intensive lowering of low-density lipoprotein cholesterol (LDL-C) levels with PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors for cardiovascular event reduction has largely been reserved for patients with significant atherosclerosis. To investigate whether evolocumab could prevent a first major cardiovascular event (MACE) in patients without known significant atherosclerosis. VESALIUS-CV was a randomized, double-blind, placebo-controlled trial of evolocumab conducted across 774 sites in 33 countries and enrolling 12 257 patients with no prior myocardial infarction or stroke, LDL-C level 90 mg/dL or greater, and qualifying atherosclerosis or high-risk diabetes. This prespecified subgroup analysis examined outcomes in patients without known significant atherosclerosis (none of the following: prior arterial revascularization, arterial stenosis ≥50%, or coronary artery calcium score ≥100 Agatston units), all of whom had diabetes. Enrollment started in June 2019 and the last patient visit was July 2025, with a median follow-up of 4.8 years. Patients were randomized in a 1:1 ratio to subcutaneous administration of either evolocumab (140 mg every 2 weeks) or matching placebo added to optimally tolerated statin therapy. The dual primary end points were composites of coronary heart disease death, myocardial infarction, or ischemic stroke (3-P MACE) and 3-P MACE plus ischemia-driven arterial revascularization (4-P MACE). Secondary end points included all-cause mortality. This predefined subgroup included 3655 patients (1849 in the evolocumab group and 1806 in the placebo group) with a median age of 65 years (57% female). Among those in the lipid substudy, the median LDL-C level at 48 weeks was 52 mg/dL in the evolocumab group vs 111 mg/dL in the placebo group (P < .001). A 3-P MACE event occurred in 83 patients (5-year Kaplan-Meier estimate, 5.0%) in the evolocumab group compared with 117 patients (5-year Kaplan-Meier estimate, 7.1%) in the placebo group (hazard ratio [HR], 0.69 [95% CI, 0.52-0.91]; P = .009; between-group difference, 2.1% [95% CI, 0.4%-3.8%]). A 4-P MACE event occurred in 127 patients (5-year Kaplan-Meier estimate, 7.6%) in the evolocumab group compared with 178 patients (5-year Kaplan-Meier estimate, 10.5%) in the placebo group (HR, 0.69 [95% CI, 0.55-0.86]; P = .001; between-group difference, 2.9% [95% CI, 0.9%-4.9%]). There were 136 deaths (5-year Kaplan-Meier estimate, 7.8%) in the evolocumab group compared with 172 deaths (5-year Kaplan-Meier estimate, 10.1%) in the placebo group (HR, 0.76 [95% CI, 0.61-0.95]). In high-risk patients without known significant atherosclerosis and with diabetes, evolocumab reduced the risk of a first major cardiovascular event. ClinicalTrials.gov Identifier: NCT03872401.32:T11e8, Importance Intensive lowering of low-density lipoprotein cholesterol (LDL-C) levels with PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors for cardiovascular event reduction has largely been reserved for patients with significant atherosclerosis. Objective To investigate whether evolocumab could prevent a first major cardiovascular event (MACE) in patients without known significant atherosclerosis. Design, Setting, and Participants VESALIUS-CV was a randomized, double-blind, placebo-controlled trial of evolocumab conducted across 774 sites in 33 countries and enrolling 12 257 patients with no prior myocardial infarction or stroke, LDL-C level 90 mg/dL or greater, and qualifying atherosclerosis or high-risk diabetes. This prespecified subgroup analysis examined outcomes in patients without known significant atherosclerosis (none of the following: prior arterial revascularization, arterial stenosis ≥50%, or coronary artery calcium score ≥100 Agatston units), all of whom had diabetes. Enrollment started in June 2019 and the last patient visit was July 2025, with a median follow-up of 4.8 years. Intervention Patients were randomized in a 1:1 ratio to subcutaneous administration of either evolocumab (140 mg every 2 weeks) or matching placebo added to optimally tolerated statin therapy. Main Outcomes and Measures The dual primary end points were composites of coronary heart disease death, myocardial infarction, or ischemic stroke (3-P MACE) and 3-P MACE plus ischemia-driven arterial revascularization (4-P MACE). Secondary end points included all-cause mortality. Results This predefined subgroup included 3655 patients (1849 in the evolocumab group and 1806 in the placebo group) with a median age of 65 years (57% female). Among those in the lipid substudy, the median LDL-C level at 48 weeks was 52 mg/dL in the evolocumab group vs 111 mg/dL in the placebo group ( P &lt; .001). A 3-P MACE event occurred in 83 patients (5-year Kaplan-Meier estimate, 5.0%) in the evolocumab group compared with 117 patients (5-year Kaplan-Meier estimate, 7.1%) in the placebo group (hazard ratio [HR], 0.69 [95% CI, 0.52-0.91]; P = .009; between-group difference, 2.1% [95% CI, 0.4%-3.8%]). A 4-P MACE event occurred in 127 patients (5-year Kaplan-Meier estimate, 7.6%) in the evolocumab group compared with 178 patients (5-year Kaplan-Meier estimate, 10.5%) in the placebo group (HR, 0.69 [95% CI, 0.55-0.86]; P = .001; between-group difference, 2.9% [95% CI, 0.9%-4.9%]). There were 136 deaths (5-year Kaplan-Meier estimate, 7.8%) in the evolocumab group compared with 172 deaths (5-year Kaplan-Meier estimate, 10.1%) in the placebo group (HR, 0.76 [95% CI, 0.61-0.95]). Conclusions and Relevance In high-risk patients without known significant atherosclerosis and with diabetes, evolocumab reduced the risk of a first major cardiovascular event. Trial Registration ClinicalTrials.gov Identifier : NCT03872401 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cardiovascular Disease Prevention: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Cardiovascular Disease Prevention (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Cardiovascular%20Disease%20Prevention\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Cardiovascular Disease Prevention\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Cardiovascular%20Disease%20Prevention\"}]}}"}}]],["$","$L2f",null,{"title":"Cardiovascular Disease Prevention: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Cardiovascular Disease Prevention with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1056/nejmoa2607314","pmid":"42670961","title":"Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults","journal_title":"New England Journal of Medicine","journal_issn":"0028-4793","published_at":"2026-08-28T00:00:00.000Z","url":"https://doi.org/10.1056/nejmoa2607314","source_score":352,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-02T06:22:30.732Z","updated_at":"2026-09-02T06:22:30.732Z","tags":[{"paper_doi":"10.1056/nejmoa2607314","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"brand","value":"Lipitor","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"condition","value":"Cardiovascular Disease Prevention","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"condition","value":"Disability-Free Survival","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"generic","value":"atorvastatin","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"modality","value":"Statin","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"sample_size","value":"n=9971","value_numeric":9971},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"warning","value":"Disability-free survival did not reach significance; secondary endpoints cannot be formally interpreted under the hierarchical testing plan used.","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"warning","value":"The impact_flag 'practice_changing' is applied because this is a large, high-quality RCT directly addressing a longstanding gap in evidence for primary prevention statin use in adults ≥70 — previously an area of significant clinical uncertainty.","value_numeric":null},{"paper_doi":"10.1056/nejmoa2607314","tag_type":"warning","value":"The 'Lipitor' brand tag is used as the most recognized brand for atorvastatin; the paper itself does not specify a brand name.","value_numeric":null}],"summaries":{"what_studied":"Double-blind RCT (STAREE trial) evaluating atorvastatin 40 mg daily vs. placebo for primary prevention of major cardiovascular events and disability-free survival in 9,971 community-dwelling adults ≥70 years (mean age 74.7 years) with no prior CVD, diabetes, or dementia, followed for a median of 5.9 years across Australian general practices.","key_result":"Atorvastatin reduced major cardiovascular events vs. placebo (10.9 vs. 15.5 per 1,000 person-years; HR 0.70, 95% CI 0.61–0.82; P<0.001), a 30% relative risk reduction. However, it did not improve disability-free survival (death, dementia, or persistent physical disability: 21.6 vs. 23.0 per 1,000 person-years; HR 0.94, 95% CI 0.84–1.05; P=0.25). Serious adverse events were similar (2.7% each arm), though musculoskeletal, hepatobiliary, and diabetes-related adverse events were more common with atorvastatin.","limitations":"- Trial enrolled only Australian community-dwelling older adults without CVD, diabetes, or dementia, limiting generalizability to more diverse or higher-risk populations.\n- The disability-free survival endpoint did not reach statistical significance, and the trial may not have been powered to detect the modest absolute difference observed (21.6 vs. 23.0 per 1,000 person-years).\n- Hierarchical testing plan means the non-significant disability-free survival result limits formal inference on secondary endpoints.","practice_takeaway":"For adults ≥70 without established CVD, atorvastatin 40 mg significantly cuts cardiovascular events but does not extend disability-free survival — clinicians should weigh this cardiovascular benefit against the lack of broader functional benefit and the small but real increase in musculoskeletal, liver, and diabetes-related side effects when initiating statins for primary prevention in older patients."}},{"doi":"10.1001/jama.2026.3277","pmid":"41903215","title":"Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes","journal_title":"JAMA","journal_issn":"0098-7484","published_at":"2026-03-29T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13033171/","source_score":427,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-01","doi":"10.1001/jama.2026.3277","days":"14","issn":"0098-7484","rank":"9","field":"Clinical Medicine","score":"427","category":"Medicine, General & Internal","categories":["Medicine, General & Internal"],"_categories":["Medicine, General & Internal"]},"pubmed":{"doi":"10.1001/jama.2026.3277","title":"Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial.","journal":"JAMA","methods":"","results":"$30","abstract":"$31","keywords":[],"pubmed_id":"41903215","conclusions":"","publication_date":"2026-03-29T00:00:00"},"crossref":{"DOI":"10.1001/jama.2026.3277","URL":"https://doi.org/10.1001/jama.2026.3277","ISSN":["0098-7484"],"link":[{"URL":"https://jamanetwork.com/journals/jama/articlepdf/2847162/jama_marston_2026_oi_260016_1776721410.63448.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1400","type":"journal-article","issue":"16","score":1,"title":["Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes"],"author":[{"given":"Nicholas A.","family":"Marston","sequence":"first","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Erin A.","family":"Bohula","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Ajay K.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Amgen Inc, Thousand Oaks, California"}]},{"given":"Gaetano M.","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medical Sciences, University of Torino and Città della Salute e della Scienza, Torino, Italy"}]},{"given":"Lawrence A.","family":"Leiter","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada"}]},{"given":"Jose C.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil"}]},{"given":"Jeong-Gun","family":"Park","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Sabina A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Emileigh","family":"Walsh","sequence":"additional","affiliation":[{"name":"Amgen Inc, Thousand Oaks, California"}]},{"given":"Lyrica","family":"Liu","sequence":"additional","affiliation":[{"name":"Amgen Inc, Thousand Oaks, California"}]},{"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, St Michael’s Hospital–Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia"}]},{"given":"Jose","family":"Lopez-Sendon","sequence":"additional","affiliation":[{"name":"Idipaz Research Institute, Hospital Universitario La Paz, UAM, Madrid, Spain"}]},{"given":"Ioanna","family":"Gouni-Berthold","sequence":"additional","affiliation":[{"name":"Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany"}]},{"given":"Lale","family":"Tokgozoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hacettepe University, Ankara, Turkiye"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Marcoli","family":"Cyrille","sequence":"additional","affiliation":[{"name":"Amgen Inc, Thousand Oaks, California"}]},{"given":"Gabriel Paiva","family":"da Silva Lima","sequence":"additional","affiliation":[{"name":"Amgen Inc, Thousand Oaks, California"}]},{"given":"Robert P.","family":"Giugliano","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":"Marc S.","family":"Sabatine","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Heart and Vascular Institute, Brigham and Women’s Hospital, Boston, Massachusetts"}]},{"given":null,"family":null,"sequence":"additional","affiliation":[]},{"given":"Alberto J.","family":"Lorenzatti","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marcos R.","family":"Litvak Bruno","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ignacio","family":"Mackinnon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Emilio D.","family":"Alaguibe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gustavo","family":"Giunta","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oscar","family":"Romano Montana","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniel","family":"Vogel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jorgelina","family":"Sala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Diego A.","family":"Besada","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Angela","family":"Romero Zarante","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marisa","family":"Vico","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tomas E.","family":"Smith Casabella","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Patricia del C.","family":"Gonzalez Colaso","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eleonora","family":"Montenegro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cesar","family":"Zaidman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria C.","family":"de Salvo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eduardo","family":"Perna","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Claudio R.","family":"Majul","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ruben O.","family":"Garcia Duran","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Miguel","family":"Hominal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sonia","family":"Hermida","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carolina","family":"Chacon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrea P.","family":"Serrano","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Juan P.","family":"Albisu Di Gennaro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Walter R.","family":"Stoermann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria V.","family":"Mansilla","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Martin","family":"Koretzky","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Leonardo","family":"Novaretto","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lilia","family":"Schiavi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andres D.","family":"Orlandini","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fernando O.","family":"Botto","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elizabeth","family":"Gelersztein","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eduardo","family":"Blumberg","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stephen","family":"Nicholls","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"John","family":"Amerena","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Walter","family":"Abhayaratna","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Philip","family":"Roberts-Thomson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthew","family":"Worthley","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Christopher","family":"Judkins","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fiona","family":"Bisshop","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alistair","family":"Begg","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Colquhoun","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Karam","family":"Kostner","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ktut","family":"Arya","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Cross","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andre","family":"Conradie","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jamie","family":"Morton","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Purnell","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrew","family":"Hamilton","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"William","family":"Van Gaal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ali","family":"Safaa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Eccleston","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Christoph","family":"Ebenbichler","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Fasching","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ursula","family":"Hanusch","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bernhard","family":"Ludvik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lukas","family":"Holzinger","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Christoph","family":"Saely","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Konstantin","family":"Krychtiuk","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thomas","family":"Stulnig","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Sinnaeve","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stephane","family":"Carlier","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc","family":"De Meulemeester","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bart","family":"Wollaert","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andre","family":"Peeters","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Benjamin","family":"Scott","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Philippe","family":"Vanduynhoven","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jan","family":"Verwerft","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tom","family":"Sarens","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Luis A.","family":"Tavares Russo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Celia R.","family":"Echeverria Sampaio","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roberto","family":"Giraldez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pedro","family":"Pimentel Filho","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joao L.","family":"Cunha Borges","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Miguel","family":"Nasser Hissa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose A.","family":"Ribas Fortes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rodrigo J.","family":"Cerci","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lilia","family":"Nigro Maia","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adrian P.","family":"Kormann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Flavia","family":"Arantes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gilmar","family":"Reis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose F.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dalton","family":"Bertolim Precoma","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Paulo R.","family":"Ferreira Rossi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Flavio E.","family":"Giorgeto","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adamastor","family":"Pereira","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Luiz C.","family":"Bodanese","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria H.","family":"Vidotti","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Raphael A.","family":"Barreto da Silva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krassimir","family":"Cvetkov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Georgi","family":"Todorov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valeri","family":"Gelev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivaylo","family":"Vasilev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Haralambi","family":"Benov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Assen","family":"Goudev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Arman","family":"Postadzhiyan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Atanas","family":"Koundurdjiev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krastyu","family":"Penchev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vladimir","family":"Zhelev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mariya","family":"Tokmakova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria","family":"Milanova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Snezhanka","family":"Tisheva- Gospodinova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valentina","family":"Mincheva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria","family":"Tzekova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bojidar","family":"Dimov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krasimira","family":"Hristova-Tselova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Dotcheva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kostadin","family":"Kichukov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"Schlosser","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Mazer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Christian","family":"Constance","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Harpreet","family":"Bajaj","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexis","family":"Baass","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jason","family":"Burstein","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sorin","family":"Beca","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sam","family":"Henein","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"George","family":"Tsoukas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jean","family":"Bergeron","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniel","family":"Gaudet","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Hartleib","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Heffernan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"James","family":"Cha","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sean","family":"Peterson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chetna","family":"Tailor","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hani","family":"Alasaad","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Iqbal","family":"Bata","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gerald","family":"Vallieres","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ronald","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dennis","family":"OKeefe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Buki","family":"Ajala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vincent","family":"Woo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Derek","family":"Yung","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hasnain","family":"Khandwala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dante","family":"Manyari","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Milan","family":"Gupta","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eva","family":"Lonn","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jacob","family":"Udell","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yaariv","family":"Khaykin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Petr","family":"Frana","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stanislav","family":"Zemek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Libor","family":"Sknouril","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexandr","family":"Schee","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ladislav","family":"Pazdera","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pavel","family":"Koleckar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eva","family":"Zidkova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Juraj","family":"Bujdak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jan","family":"Kvasnicka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vladimir","family":"Blaha","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robin","family":"Urbanek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Petr","family":"Reichert","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivo","family":"Podpera","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Petr","family":"Dulicek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Martina","family":"Machkova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nadezda","family":"Fiserova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sylva","family":"Brtnikova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zbynek","family":"Pozdisek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michal","family":"Cepelak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vladimir","family":"Cech","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Miroslav","family":"Homza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janka","family":"Skrobakova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lubomir","family":"Elbl","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Petr","family":"Kala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lea","family":"Raclavska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jiri","family":"Vesely","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Karel","family":"Sochor","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Radim","family":"Kryza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dagmar","family":"Bartaskova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jiri","family":"Krupicka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jiri","family":"Matuska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jakub","family":"Hron","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marian","family":"Pirchala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ladislav","family":"Busak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dusan","family":"Kucera","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lukas","family":"Zlatohlavek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marek","family":"Houra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vit","family":"Reznicek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jaroslav","family":"Brotanek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rostislav","family":"Polasek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ilona","family":"Parenicova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lumir","family":"Francek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Milan","family":"Sepsi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jan","family":"Vaclavik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pavel","family":"Kukla","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ladislav","family":"Kuchar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Igor","family":"Karen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roman","family":"Miklik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zbynek","family":"Kosek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nikolaj T.","family":"Krarup","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Henrik","family":"Kjaerulf Jensen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Sogaard","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tem","family":"Bendix Salkvist Jorgensen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kristian","family":"Korsgaard Thomsen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Morten","family":"Bottcher","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nikolaj","family":"Eldrup","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elgina","family":"Kamil Thomsen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Annette","family":"Hoi Justesen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Soren R.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jorn M.","family":"Jepsen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bernt","family":"Husoy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivo","family":"Valter","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Arvo","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Liina","family":"Viitas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marika","family":"Paumets","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sakari","family":"Nieminen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joni","family":"Suomi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anna-Mari","family":"Koski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Johanna","family":"Kuusisto","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kai","family":"Nyman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kari","family":"Kervinen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tuomas","family":"Rissanen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janne","family":"Hukkanen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jyrki","family":"Taurio","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Timo","family":"Strandberg","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gilles","family":"Lemesle","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Franck","family":"Boccara","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gregory","family":"Ducrocq","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marie-Antoinette","family":"Sevestre","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bruno","family":"Farah","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thierry","family":"Fourme","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Francois","family":"Paillard","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Emmanuel","family":"Messas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gilles","family":"Barone Rochette","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexandre","family":"Canville","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Meyer","family":"Elbaz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pierre","family":"Poustis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Guillaume","family":"Cayla","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jean-Louis","family":"Georges","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fitsum","family":"Guebre Egziabher","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Frederic","family":"Chague","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Victor","family":"Buzura","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sybil","family":"Charriere","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Patrick","family":"Khanoyan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gregoire","family":"Range","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Emile","family":"Ferrari","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Francois","family":"Roubille","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Farzin","family":"Beygui","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sebastien","family":"Caudmont","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ingo","family":"Weigmann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Isabelle","family":"Schenkenberger","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Manuela","family":"Licka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maritta","family":"Marks","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Katrin","family":"Borucki","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andreas J.","family":"Rieth","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Karl-Friedrich","family":"Appel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ursula","family":"Kassner","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andreas","family":"Wilke","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Christoph","family":"Axthelm","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Frank","family":"Schaper","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Martin","family":"Bergmann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ksenija","family":"Stach-Jablonski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joerg","family":"Simon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marcus","family":"Fischer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stefan","family":"Leggewie","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jens","family":"Taggeselle","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sebastian","family":"Cremer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Katrin","family":"Gebauer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gerd","family":"Kahrmann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Bosiljanoff","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jens","family":"Placke","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc","family":"Kollum","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bernhard","family":"Winkelmann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Konstantinos","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sotirios","family":"Patsilinakos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Georgios","family":"Liamis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Konstantinos","family":"Tziomalos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ioannis","family":"Styliadis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elias","family":"Tsougos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Athanasios","family":"Protogerou","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"George","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Katerina","family":"Naka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Apostolos","family":"Karavidas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Niki","family":"Katsiki","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anastasios","family":"Milkas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Evgenia","family":"Mavrokefalou","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Theodosios","family":"Filippatos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"Kiss","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bela","family":"Merkely","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mariann","family":"Harangi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kalman","family":"Toth","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Imre","family":"Ungi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janos","family":"Tomcsanyi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zoltan","family":"Csanadi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniel","family":"Aradi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Laszlo","family":"Mark","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zsolt","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andras","family":"Papp","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Geza","family":"Lupkovics","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Aniko","family":"Papp","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bela","family":"Benczur","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrea","family":"Hornyik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ferenc","family":"Lakatos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janos","family":"Mucsi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Laszlo","family":"Nagy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Imre","family":"Szakal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Attila","family":"Mohacsi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Istvan","family":"Reiber","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jozsef","family":"Lippai","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Laszlo","family":"Konyves","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Csaba","family":"Hajdu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sandor","family":"Hamar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Balazs","family":"Sarman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Attila","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Danos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gergely G.","family":"Nagy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tamas","family":"Barany","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Istvan","family":"Berhes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andras C.","family":"Nagy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Piera A.","family":"Merlini","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Giovanni","family":"Licciardello","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maria P.A.","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Enrico","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Giuliano","family":"Tocci","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Salvatore","family":"De Rosa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nazzareno","family":"Galie","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roberto","family":"Trevisan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gaetano M.","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniela","family":"Trabattoni","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Inga","family":"Morozova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dace","family":"Teterovska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrejs","family":"Erglis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Irina","family":"Veze","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Inga","family":"Jasinkevica","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jolita","family":"Badariene","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lina","family":"Venceviciene","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rimvydas","family":"Slapikas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gediminas","family":"Urbonas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valdas","family":"Dobilas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Danute","family":"Strazdiene","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nora","family":"Kupstyte-Kristapone","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roma","family":"Kavaliauskiene","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Enrique","family":"Morales Villegas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fernando","family":"Aguilera Almazan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vicente E.","family":"Ruiz Ruiz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marco A.","family":"Alcocer Gamba","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Raymundo","family":"Garcia Reza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Manuel","family":"De los Rios Ibarra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ismail","family":"Aksoy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Floris","family":"Kauer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ruud","family":"van de Wal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anthonius","family":"Oude Ophuis","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fransisco","family":"Prins","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Walter","family":"Hermans","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Frank","family":"Janse","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stefan","family":"Koudstaal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mireille","family":"Emans","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pieter","family":"Hoogslag","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gerard","family":"Bartels","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thierry","family":"Wildbergh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthijs","family":"Meijs","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eelko","family":"Ronner","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Iris","family":"Westendorp","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lennaert","family":"Kleijn","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pieter","family":"Dijkmans","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lambertus","family":"Pos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Saman","family":"Rasoul","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jeroen","family":"Schaap","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maarten","family":"Asselman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Margriet","family":"Feenema-Aardema","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Reginald","family":"Groutars","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pieter","family":"Nierop","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hendrik","family":"Swart","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Erik","family":"Badings","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc","family":"van der Zee","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Wouter","family":"Remkes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Johannes","family":"Herrman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Paul","family":"van Bergen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Erik","family":"Stroes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Simone","family":"Hartong","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adriaan","family":"Kooy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Johannes","family":"Post","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marcel","family":"van de Ree","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Willem","family":"Bax","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Frank","family":"Visseren","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Houshang","family":"Monajemi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Saloua","family":"el Messaoudi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ravee","family":"Rambharose","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thomas","family":"Van Bemmel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Catharina","family":"Daemen-Gubbels","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mazin","family":"Alhakim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bernard","family":"Rensing","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rien","family":"Dekkers","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ahmet","family":"Adiyaman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valeria","family":"Paradies","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Remy","family":"Bemelmans","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Boudewijn","family":"Hoek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ralph","family":"Verkleij","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zbigniew","family":"Bednarkiewicz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janusz","family":"Spyra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michal","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maciej","family":"Zabowka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Wojciech","family":"Telec","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zbigniew","family":"Pijanowski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mariusz","family":"Kafara","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marek","family":"Piepiorka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jerzy","family":"Kopaczewski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Boguslaw","family":"Grzegorzewski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Grzegorz","family":"Kania","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lukasz","family":"Wojnowski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrzej","family":"Budaj","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Iwona","family":"Wozniak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jacek","family":"Kieltucki","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Wojciech","family":"Czochra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lidia","family":"Pawlowicz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adrian","family":"Wlodarczak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elzbieta","family":"Dulak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pawel","family":"Staneta","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Janusz","family":"Bednarski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Benita","family":"Busz-Papiez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Beata","family":"Wozakowska-Kaplon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Piotr","family":"Rozpondek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marlena","family":"Broncel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tomasz","family":"Czerski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michal","family":"Zabojszcz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krzysztof","family":"Cieslik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"Glowka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krzysztof","family":"Saminski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marcin","family":"Skorski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dariusz","family":"Surman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joanna","family":"Niegowska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Piotr","family":"Napora","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Piotr","family":"Karas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ewa","family":"Mirek-Bryniarska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lukasz","family":"Artyszuk","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Monika","family":"Tomaszewska-Kiecana","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joanna","family":"Biegajlo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Grzegorz","family":"Skonieczny","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Magdalena","family":"Loster","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Krzysztof","family":"Chlebus","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ewa","family":"Jazwinska-Tarnawska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Aleksander","family":"Zurakowski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Grzegorz","family":"Drelich","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dariusz","family":"Dudek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Artur","family":"Klecha","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adam","family":"Deres","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Magda","family":"Dabrowska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jerzy","family":"Cygler","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carlos","family":"Aguiar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pedro","family":"Matos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Helder","family":"Pereira","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pedro","family":"Monteiro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cristina","family":"Gavina","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pedro","family":"Azevedo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Manuela","family":"Vieira","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rogerio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Olga","family":"Azevedo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gabriela E.","family":"Stanciulescu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Constantin","family":"Militaru","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dragos","family":"Vinereanu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cristian G.","family":"Podoleanu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marilena R.","family":"Spiridon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dana","family":"Cosma","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ella","family":"Pintilei","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carmen","family":"Crisan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Laurentia D.","family":"Andrei","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleg","family":"Averkov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Radchenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yulia","family":"Argunova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Svetlana","family":"Berns","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexander","family":"Bykov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mikhail","family":"Voevoda","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivan","family":"Gordeev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dmitry","family":"Dronov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nadezhda","family":"Veselovskaya","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dmitry","family":"Duplyakov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marat","family":"Ezhov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Konstantin","family":"Zrazhevskiy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mikhail","family":"Zykov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Zhanna","family":"Kobalava","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Natalya","family":"Koziolova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Kosmacheva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Viktor","family":"Kostenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Kulibaba","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Natalya","family":"Lozhkina","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yury","family":"Lukyanov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valeriy","family":"Makukhin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Aleksey","family":"Meshkov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Viktor","family":"Milyagin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vladimir","family":"Nosov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Irina","family":"Osipova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Pavlysh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Leonid","family":"Pimenov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vyacheslav","family":"Ryabov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Irina","family":"Semenova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Olga","family":"Smolenskaya","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleg","family":"Solovev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Maxim","family":"Sorokin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mikhail","family":"Statsenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tatiana","family":"Treshkur","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sergey","family":"Shalaev","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Evgeny","family":"Petrik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yury","family":"Shvarts","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Valerii","family":"Popov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Elena","family":"Shutemova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Victor","family":"Mordovin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Evgeny","family":"Morozov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ruslan","family":"Sardinov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexander","family":"Sherenkov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tatiana","family":"Sveklina","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniel","family":"Pella","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Fulop","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lubomir","family":"Antalik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jozef","family":"Semetko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivan","family":"Majercak","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jan","family":"Nociar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rudolf","family":"Smik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrej","family":"Dzupina","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniela","family":"Vinanska","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michal","family":"Banik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alexander","family":"Klabnik","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roman","family":"Oriesek","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ivana","family":"Soosova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rudolf","family":"Uhliar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jana","family":"Lukacova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dalibor","family":"Sosovec","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jozef","family":"Lacka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dasa","family":"Skripova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lubica","family":"Urgeova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kyung W.","family":"Park","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Young W.","family":"Jang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tae-Hyun","family":"Yang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Byung J.","family":"Kim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chang-Wook","family":"Nam","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Soon J.","family":"Hong","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jong S.","family":"Park","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bum K.","family":"Hong","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Doo S.","family":"Sim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Weon","family":"Kim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yun-Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cheol W.","family":"Lee","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Byeong-Keuk","family":"Kim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Myeong-Chan","family":"Cho","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joo-Yong","family":"Hahn","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"SungGyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"So-Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"In-Ho","family":"Chae","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carmen","family":"Suarez Fernandez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daiana","family":"Ibarretxe Gerediaga","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Estibaliz","family":"Jarauta Simon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose","family":"Lopez Miranda","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Agustin","family":"Blanco Echevarria","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Francisco J.","family":"Tinahones Madueño","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nuria","family":"Alonso Pedrol","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carlos","family":"Brotons Cuixart","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Juan F.","family":"Merino Torres","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Juan F.","family":"Arenillas Lara","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Miguel A.","family":"Vazquez Ronda","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Emilio","family":"Ortega Martinez de Victoria","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rafael J.","family":"Hidalgo Urbano","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andres","family":"Iñiguez Romo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose R.","family":"Gonzalez Juanatey","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Miguel","family":"Civera Andres","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Violeta","family":"Rodriguez Rodriguez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Regina","family":"Dalmau Gonzalez-Gallarza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jesus","family":"Peteiro Vazquez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joao L.","family":"Modesto dos Santos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose A.","family":"Martin Armas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pablo","family":"Gonzalez Bustos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Domingo A.","family":"Pascual Figal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thomas","family":"Mooe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carl-Johan","family":"Lindholm","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Asa","family":"Drakesby","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stefan","family":"Soderberg","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jacob","family":"Odenstedt","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ake","family":"Olsson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Magnus","family":"Peterson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pekka","family":"Koskinen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Staffan","family":"Salmonsson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rudolfs","family":"Sakne","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Par","family":"Bjorklund","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tsung-Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chin-Chou","family":"Huang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"I-Te","family":"Lee","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ji-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hung-I","family":"Yeh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yi-Chih","family":"Wang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yi-Heng","family":"Li","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"I-Chang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chiung-Jen","family":"Wu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chien-Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vira","family":"Tseluyko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Roman","family":"Stets","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mykola","family":"Stanislavchuk","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Leonid","family":"Rudenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mykola","family":"Rishko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anna","family":"Popova","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleksandr","family":"Prokhorov","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleksandr","family":"Parkhomenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Iuliia","family":"Melashchenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Larysa","family":"Mishchenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Yurii","family":"Lymar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleksii","family":"Korzh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Oleksandr","family":"Karpenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Igor","family":"Vakaliuk","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Liudmyla","family":"Alieksieieva","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Olena","family":"Mitchenko","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Damien","family":"McNally","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ryan","family":"D Costa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Terry","family":"McCormack","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Adrian","family":"Beltran-Martinez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Derek","family":"Connolly","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Deepa","family":"Narayanan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dirk","family":"Felmeden","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stephen","family":"Bain","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mary","family":"Lynch","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Neil","family":"Paul","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Richard","family":"Burkimsher","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"John","family":"Webster","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Patrick","family":"Donnelly","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ponnusamy","family":"Saravanan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Louise","family":"Shaw","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Basil","family":"Issa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rashed","family":"Hossain","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ronak","family":"Rajani","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alex","family":"Bickerton","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Abdul","family":"Negahban","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Patrick","family":"Moore","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Susan","family":"Fairhead","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Amardeep","family":"Heer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sam","family":"Davies","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Peter","family":"Wilson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alan","family":"Jackson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Shanmugapriya","family":"Ganeshkumar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Gordon","family":"Irvine","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anton","family":"Poterajlo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Beata","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Paul","family":"Walukiewicz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Joshua","family":"Asubiaro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Motunrayo","family":"Adesanya","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Iulia","family":"Dinu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Devaki","family":"Nair","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Shamaila","family":"Aslam","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Lillestol","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Samir","family":"Abdelshaheed","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nicolas","family":"Shammas","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Tehreen","family":"Khan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Edward","family":"Portnay","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Narendra","family":"Singh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Steven","family":"Brodie","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Faisal","family":"Wahid","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vladimir","family":"Santos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Thomas","family":"Knickelbine","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Shapiro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Madaiah","family":"Revana","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vance","family":"Wilson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vikas","family":"Desai","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Steven","family":"Hearne","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kenneth","family":"Hershon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Norman","family":"Lepor","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Paul","family":"Ziajka","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ronald","family":"Fritz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Pratik","family":"Mondal","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alan","family":"Wiseman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"John","family":"Nayda","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Colby","family":"Grossman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Steven","family":"Lupovitch","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Leslie","family":"Forgosh","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Stephen","family":"Grubb","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sandeep","family":"Khurana","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sumana","family":"Gangi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Philip","family":"Nicol","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"William","family":"Smith","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Minesh","family":"Patel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Fernando","family":"Boccalandro","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kenneth","family":"Hilty","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Scott","family":"Gabler","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Carlos","family":"Sotolongo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Brian","family":"Bergmark","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rebecca","family":"Jordan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"J Russell","family":"Strader","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sean","family":"Donahoe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sumant","family":"Lamba","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Catherine","family":"P. Benziger","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ahmed","family":"Arif","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Wael","family":"Eid","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Samer","family":"Nakhle","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Faiq","family":"Akhter","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jakkidi","family":"Reddy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"William","family":"Pomeroy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ayotunde","family":"Dokun","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"Cohen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Drew","family":"Purdy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jonathan","family":"Purnell","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rakesh","family":"Prashad","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dominick","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Hafran","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Kevin","family":"DeAndrade","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Karen","family":"Aspry","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Archna","family":"Bajaj","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Randall","family":"Miller","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lance","family":"Sloan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chrisette","family":"Dharma","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Terence","family":"Connelly","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Walter","family":"Haught","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Louis","family":"Kantaros","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hugh","family":"Durrence","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ira","family":"Lieber","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mahfouz","family":"El Shahawy","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Chad","family":"Travers","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ranganatha","family":"Potu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mark","family":"Tannenbaum","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ira","family":"Dauber","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sharath","family":"Subramanian","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Venkatesh","family":"Nadar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mourhaf","family":"Traboulssi","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jeremy","family":"Cox","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dean","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Luther","family":"Carter","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Amit","family":"Shah","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dominic","family":"Onyema","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Naim","family":"Farhat","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Daniel","family":"Humiston","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mariana","family":"Garcia-Touza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Aryan","family":"Aiyer","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Koren","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Dinesh","family":"Arab","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthew","family":"Voss","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sanjay","family":"Vora","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose","family":"Perez","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ronald","family":"Mayfield","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ronald","family":"Karlsberg","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cara","family":"East","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bruce","family":"Iteld","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jonathan","family":"Fialkow","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrew","family":"Teklinski","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc","family":"Bernstein","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Vinay","family":"Malhotra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Libby","family":"Lake","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Bryan","family":"Austin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"George","family":"Platt","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthew","family":"Cavender","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Nicole","family":"Pant","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"James","family":"Hansen","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert","family":"McNeill","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Anil","family":"Chhabra","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Naseem","family":"Jaffrani","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Jones","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ayim","family":"Akyea-Djamson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Mauricio","family":"Concha","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andreas","family":"Wali","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eugenia","family":"Gianos","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Cyrus","family":"Desouza","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Linda","family":"Bassett Shaftoe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Alfred","family":"Tan","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Josiah","family":"Zubairu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"William","family":"Eaves","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Eric","family":"Auerbach","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lisa","family":"Connery","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Michael","family":"Jardula","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"David","family":"Kandath","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sam","family":"Lerman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Edward","family":"Teufel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sabrina","family":"Benjamin","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Sandeep","family":"Bajaj","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Justin","family":"Arambasick","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Andrew","family":"Feldman","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Axel","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ingibjorg","family":"Gudmundsdottir","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose","family":"Nicolau","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lawrence","family":"Leiter","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ma","family":"Changsheng","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jindrich","family":"Spinar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Margus","family":"Viigimaa","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ioanna","family":"Gouni-Berthold","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jan H.","family":"Cornel","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jorge","family":"Ferreira","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Hyo-soo","family":"Kim","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jose","family":"Lopez-Sendon","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Min-Ji","family":"Charng","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Lale","family":"Tokgozoglu","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Jeffery","family":"Saver","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc","family":"Bonaca","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Rafael","family":"Diaz","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Matthew","family":"Roe","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Robert P.","family":"Giugliano","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Erin A.","family":"Bohula","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]},{"given":"Marc S.","family":"Sabatine","sequence":"additional","affiliation":[{"name":"for the VESALIUS-CV Investigators"}]}],"issued":{"date-parts":[[2026,4,28]]},"member":"10","prefix":"10.1001","source":"Crossref","volume":"335","created":{"date-time":"2026-03-28T21:30:19Z","timestamp":1774733419000,"date-parts":[[2026,3,28]]},"indexed":{"date-time":"2026-04-29T20:48:10Z","timestamp":1777495690143,"date-parts":[[2026,4,29]]},"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"https://jamanetwork.com/journals/jama/fullarticle/2847162"}},"subtitle":["Results From the VESALIUS-CV Trial"],"deposited":{"date-time":"2026-04-28T15:01:16Z","timestamp":1777388476000,"date-parts":[[2026,4,28]]},"issn-type":[{"type":"print","value":"0098-7484"}],"published":{"date-parts":[[2026,4,28]]},"publisher":"American Medical Association (AMA)","reference":[{"DOI":"10.3390/jcm12185839","key":"joi260016r1","year":"2023","issue":"18","author":"Mercep","volume":"12","first-page":"5839","unstructured":null,"article-title":"Present and future of dyslipidaemia treatment—a review.","journal-title":"J Clin Med","doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1615664","key":"joi260016r2","year":"2017","issue":"18","author":"Sabatine","volume":"376","first-page":"1713","unstructured":null,"article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","journal-title":"N Engl J Med","doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1801174","key":"joi260016r3","year":"2018","issue":"22","author":"Schwartz","volume":"379","first-page":"2097","unstructured":null,"article-title":"Alirocumab and cardiovascular outcomes after acute coronary syndrome.","journal-title":"N Engl J Med","doi-asserted-by":"publisher"},{"DOI":"10.1161/CIR.0000000000000625","key":"joi260016r4","year":"2019","issue":"25","author":"Grundy","volume":"139","first-page":"e1082","unstructured":null,"article-title":"2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.","journal-title":"Circulation","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jacc.2022.07.006","key":"joi260016r5","year":"2022","issue":"14","author":"Lloyd-Jones","volume":"80","first-page":"1366","unstructured":null,"article-title":"2022 ACC expert consensus decision pathway on the role of nonstatin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Solution Set Oversight Committee.","journal-title":"J Am Coll Cardiol","doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa2514428","key":"joi260016r6","year":"2026","issue":"2","author":"Bohula","volume":"394","first-page":"117","unstructured":null,"article-title":"Evolocumab in patients without a previous myocardial infarction or stroke.","journal-title":"N Engl J Med","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ahj.2023.12.004","key":"joi260016r7","year":"2024","issue":null,"author":"Bohula","volume":"269","first-page":"179","unstructured":null,"article-title":"Rationale and design of the effect of evolocumab in patients at high cardiovascular risk without prior myocardial infarction or stroke (VESALIUS-CV) trial.","journal-title":"Am Heart J","doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140-6736(10)61350-5","key":"joi260016r8","year":"2010","issue":"9753","author":"Baigent","volume":"376","first-page":"1670","unstructured":null,"article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.","journal-title":"Lancet","doi-asserted-by":"publisher"},{"DOI":"10.2337/dc26-S010","key":"joi260016r9","year":"2026","issue":null,"author":"American Diabetes Association Professional Practice Committee for Diabetes","volume":"49","first-page":"S216","unstructured":null,"article-title":"Cardiovascular disease and risk management: standards of care in diabetes–2026.","journal-title":"Diabetes Care","doi-asserted-by":"publisher"},{"DOI":"10.1093/eurheartj/ehz455","key":"joi260016r10","year":"2020","issue":"1","author":"Mach","volume":"41","first-page":"111","unstructured":null,"article-title":"2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.","journal-title":"Eur Heart J","doi-asserted-by":"publisher"},{"DOI":"10.1093/eurheartj/ehaf190","key":"joi260016r11","year":"2025","issue":"42","author":"Mach","volume":"46","first-page":"4359","unstructured":null,"article-title":"2025 Focused update of the 2019 ESC/EAS guidelines for the management of dyslipidaemias.","journal-title":"Eur Heart J","doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140-6736(16)31357-5","key":"joi260016r12","year":"2016","issue":"10059","author":"Collins","volume":"388","first-page":"2532","unstructured":null,"article-title":"Interpretation of the evidence for the efficacy and safety of statin therapy.","journal-title":"Lancet","doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2016.16951","key":"joi260016r13","year":"2016","issue":"22","author":"Nicholls","volume":"316","first-page":"2373","unstructured":null,"article-title":"Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial.","journal-title":"JAMA","doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.118.034309","key":"joi260016r14","year":"2018","issue":"8","author":"Sabatine","volume":"138","first-page":"756","unstructured":null,"article-title":"Clinical benefit of evolocumab by severity and extent of coronary artery disease: analysis from FOURIER.","journal-title":"Circulation","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jacc.2023.11.029","key":"joi260016r15","year":"2024","issue":"6","author":"McClintick","volume":"83","first-page":"652","unstructured":null,"article-title":"Long-term efficacy of evolocumab in patients with or without multivessel coronary disease.","journal-title":"J Am Coll Cardiol","doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140-6736(12)60367-5","key":"joi260016r16","year":"2012","issue":"9841","author":"Mihaylova","volume":"380","first-page":"581","unstructured":null,"article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.","journal-title":"Lancet","doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,4,28]]}},"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["JAMA"],"published-print":{"date-parts":[[2026,4,28]]},"reference-count":16,"published-online":null,"references-count":16,"short-container-title":["JAMA"],"is-referenced-by-count":1},"unpaywall":{"doi":"10.1001/jama.2026.3277","is_oa":true,"title":"Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes","updated":"2026-04-02T16:24:14+00:00","published_date":"2026-03-28","best_oa_location":{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13033171/","pmh_id":"oai:pubmedcentral.nih.gov:13033171","url_for_pdf":null,"url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13033171/"}}},"created_at":"2026-05-07T22:49:08.096Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1001/jama.2026.3277","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"brand","value":"Repatha","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"condition","value":"Cardiovascular Disease Prevention","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"condition","value":"Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"condition","value":"Hyperlipidemia","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"generic","value":"evolocumab","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"modality","value":"PCSK9 Inhibitor","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"sample_size","value":"n=3655","value_numeric":3655},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"study_design","value":"Randomized Controlled Trial (Prespecified Subgroup Analysis)","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"warning","value":"Full-text was inaccessible; safety and tolerability data (e.g., adverse events) could not be extracted and are not reflected in the summary.","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"warning","value":"The median age of 65 years and 57% female composition may not represent all diabetic patient populations seen in primary prevention settings.","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"warning","value":"The 'practice_changing' flag is applied cautiously — this subgroup analysis supports a shift in PCSK9 inhibitor use to primary prevention in diabetic patients, but guideline updates will be needed to confirm broad adoption.","value_numeric":null},{"paper_doi":"10.1001/jama.2026.3277","tag_type":"warning","value":"This is a prespecified subgroup analysis, not the primary trial result — findings should be interpreted with appropriate caution regarding statistical power and multiple comparisons.","value_numeric":null}],"summaries":{"what_studied":"This prespecified subgroup analysis of the VESALIUS-CV RCT evaluated whether evolocumab (140 mg subcutaneously every 2 weeks) vs placebo, added to optimally tolerated statin therapy, could prevent a first major cardiovascular event (MACE) in 3,655 patients with diabetes but **no** known significant atherosclerosis (no prior MI or stroke, no revascularization, no arterial stenosis ≥50%, no CAC ≥100), followed for a median of 4.8 years.","key_result":"Evolocumab reduced 3-P MACE (CHD death, MI, ischemic stroke) by 31% vs placebo (5.0% vs 7.1%; HR 0.69 [95% CI 0.52–0.91]; absolute difference 2.1%). It also cut 4-P MACE by 31% (7.6% vs 10.5%; HR 0.69 [95% CI 0.55–0.86]; absolute difference 2.9%) and showed a mortality signal (7.8% vs 10.1%; HR 0.76 [95% CI 0.61–0.95]). Median LDL-C at 48 weeks was 52 mg/dL (evolocumab) vs 111 mg/dL (placebo).","limitations":"- This is a **prespecified subgroup** of the main VESALIUS-CV trial, so statistical power was designed for the overall cohort, not this subgroup alone.\n- All patients in this subgroup had diabetes, limiting generalizability to non-diabetic patients without significant atherosclerosis.\n- Full-text safety and tolerability data were not accessible from the available abstract.","practice_takeaway":"Consider evolocumab as a primary prevention option in patients with diabetes and elevated LDL-C (≥90 mg/dL) who lack known significant atherosclerosis — a population previously excluded from routine PCSK9 inhibitor use. A 2.1% absolute reduction in 3-P MACE over ~5 years translates to roughly 1 event prevented per 48 patients treated."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Cardiovascular Disease Prevention"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Cardiovascular Disease Prevention"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Cardiovascular Disease Prevention"}}}]]

Papers