2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Tb01,As health insurers, payers, and policymakers look to Merit-Based Incentive Payment System (MIPS) measures to judge eye care quality, compare surgeon performance, and make decisions about reimbursement, it is essential to understand the validity and generalizability of these metrics. To assess the validity and generalizability of 2024 MIPS measure 191, Cataracts: 20/40 or Better Visual Acuity Within 90 Days Following Cataract Surgery. This was a retrospective cohort study of patients who underwent at least 1 cataract surgery from 2010 through 2023 at any of 16 participating health systems in the Sight Outcomes Research Collaborative (SOURCE). The study assessed whether patient demographic characteristics and nonclinical and clinical factors were associated with achieving success, which MIPS measure 191 defines as a best recorded visual acuity of at least 20/40 within 90 days following cataract surgery. Data analysis was conducted from June 2024 to December 2025. Cataract surgery. The percentage of patients undergoing cataract surgery achieving success and the odds of surgical success were determined; for patients with 2 operative eyes, only the first eye surgery was assessed. Success rates were evaluated among all surgery recipients and separately among patients with no preexisting chronic ocular diseases as specified by the metric. Success rates were quantified using more stringent cutoffs and adjusting the follow-up duration. Logistic regression models assessed how nonbiological determinants of health and clinical factors influenced the odds of success. A total of 55 132 patients underwent cataract surgery (mean [SD] age, 70.3 [9.3] years; 32 240 [58.5%] female; 1973 [3.6%] Asian American; 7053 [12.8%] Black; 1993 [3.6%] Hispanic; 42 178 [76.5%] White [race and ethnicity were self-reported]). Among all patients undergoing surgery, 49 979 (90.7%) achieved surgical success. Excluding patients with ocular comorbidities (25 563 patients [46.4%]), 28 242 of 29 569 (95.5%) achieved surgical success. Living in the least (vs most) affluent community (odds ratio [OR], 0.81; 95% CI, 0.72-0.91), undergoing complex surgery (OR, 0.82; 95% CI, 0.75-0.89) or a combination of cataract with another intraocular surgery (OR, 0.32; 95% CI, 0.29-0.35), and having diabetes (OR, 0.90; 95% CI, 0.84-0.98) were associated with lower odds of surgical success. In this cohort study, most patients undergoing cataract surgery achieved success as defined by MIPS measure 191; however, the existing measure excluded nearly half of patients undergoing surgery, and older patients and Black patients were more likely to be excluded. Case-mix adjustment of patients' sociodemographic characteristics and clinical factors may be necessary to ensure fairness when comparing surgeons' performance.31:Tfd5, Importance As health insurers, payers, and policymakers look to Merit-Based Incentive Payment System (MIPS) measures to judge eye care quality, compare surgeon performance, and make decisions about reimbursement, it is essential to understand the validity and generalizability of these metrics. Objective To assess the validity and generalizability of 2024 MIPS measure 191, Cataracts: 20/40 or Better Visual Acuity Within 90 Days Following Cataract Surgery. Design, Setting, Participants This was a retrospective cohort study of patients who underwent at least 1 cataract surgery from 2010 through 2023 at any of 16 participating health systems in the Sight Outcomes Research Collaborative (SOURCE). The study assessed whether patient demographic characteristics and nonclinical and clinical factors were associated with achieving success, which MIPS measure 191 defines as a best recorded visual acuity of at least 20/40 within 90 days following cataract surgery. Data analysis was conducted from June 2024 to December 2025. Exposures Cataract surgery. Main Outcomes and Measures The percentage of patients undergoing cataract surgery achieving success and the odds of surgical success were determined; for patients with 2 operative eyes, only the first eye surgery was assessed. Success rates were evaluated among all surgery recipients and separately among patients with no preexisting chronic ocular diseases as specified by the metric. Success rates were quantified using more stringent cutoffs and adjusting the follow-up duration. Logistic regression models assessed how nonbiological determinants of health and clinical factors influenced the odds of success. Results A total of 55 132 patients underwent cataract surgery (mean [SD] age, 70.3 [9.3] years; 32 240 [58.5%] female; 1973 [3.6%] Asian American; 7053 [12.8%] Black; 1993 [3.6%] Hispanic; 42 178 [76.5%] White [race and ethnicity were self-reported]). Among all patients undergoing surgery, 49 979 (90.7%) achieved surgical success. Excluding patients with ocular comorbidities (25 563 patients [46.4%]), 28 242 of 29 569 (95.5%) achieved surgical success. Living in the least (vs most) affluent community (odds ratio [OR], 0.81; 95% CI, 0.72-0.91), undergoing complex surgery (OR, 0.82; 95% CI, 0.75-0.89) or a combination of cataract with another intraocular surgery (OR, 0.32; 95% CI, 0.29-0.35), and having diabetes (OR, 0.90; 95% CI, 0.84-0.98) were associated with lower odds of surgical success. Conclusions and Relevance In this cohort study, most patients undergoing cataract surgery achieved success as defined by MIPS measure 191; however, the existing measure excluded nearly half of patients undergoing surgery, and older patients and Black patients were more likely to be excluded. Case-mix adjustment of patients’ sociodemographic characteristics and clinical factors may be necessary to ensure fairness when comparing surgeons’ performance. 32:T687,The corneal triple procedure, combining keratoplasty, cataract extraction, and intraocular lens implantation, remains a valuable option for patients with concurrent corneal opacity and cataract. We synthesize historical and contemporary evidence on penetrating keratoplasty (PKP), anterior lamellar keratoplasty (ALK), and endothelial keratoplasty (EK) triple procedures, highlighting their indications, surgical techniques, outcomes, and evolving trends. PKP triple is indicated for full-thickness scarring, keratoconus with central scarring, and cases with anterior segment abnormalities, but remains technically demanding due to open-sky cataract surgery and postoperative refractive unpredictability. ALK triple offers tectonic and visual rehabilitation in stromal disorders sparing the endothelium, though technically challenging. EK triple procedures, particularly Descemet stripping automated endothelial keratoplasty and Descemet membrane endothelial keratoplasty, are increasingly preferred in endothelial disorders such as Fuchs endothelial corneal dystrophy, offering faster recovery, more predictable refraction, and better graft survival. Advances in capsulotomy, nucleus management, intraocular lens power calculation, and perioperative strategies have improved safety and refractive outcomes across triple procedures. Long-term studies reveal that although visual and anatomical success rates remain high, complications such as graft rejection, glaucoma, and posterior capsular opacification persist. Careful patient selection and tailored surgical planning are essential, as triple procedures continue to evolve toward safer and more predictable outcomes.33:T83d,Looking older for one's chronological age is associated with a higher mortality rate. Yet it remains unclear how perceived facial age relates to morbidity and the degree to which facial ageing reflects systemic ageing of the human body. To investigate the association between ΔPA and age-related morbidities of different organ systems, where ΔPA represents the difference between perceived age (PA) and chronological age. We performed a cross-sectional analysis on data from the Rotterdam Study, a population-based cohort study in the Netherlands. High-resolution facial photographs of 2679 men and women aged 51.5-87.8 years of European descent were used to assess PA. PA was estimated and scored in 5-year categories using these photographs by a panel of men and women who were blinded for chronological age and medical history. A linear mixed model was used to generate the mean PAs. The difference between the mean PA and chronological age was calculated (ΔPA), where a higher (positive) ΔPA means that the person looks younger for their age and a lower (negative) ΔPA that the person looks older. ΔPA was tested as a continuous variable for association with ageing-related morbidities including cardiovascular, pulmonary, ophthalmological, neurocognitive, renal, skeletal and auditory morbidities in separate regression analyses, adjusted for age and sex (model 1) and additionally for body mass index, smoking and sun exposure (model 2). We observed 5-year higher ΔPA (i.e. looking younger by 5 years for one's age) to be associated with less osteoporosis [odds ratio (OR) 0.76, 95% confidence interval (CI) 0.62-0.93], less chronic obstructive pulmonary disease (OR 0.85, 95% CI 0.77-0.95), less age-related hearing loss (model 2; B = -0.76, 95% CI -1.35 to -0.17) and fewer cataracts (OR 0.84, 95% CI 0.73-0.97), but with better global cognitive functioning (g-factor; model 2; B = 0.07, 95% CI 0.04-0.10). PA is associated with multiple morbidities and better cognitive function, suggesting that systemic ageing and cognitive ageing are, to an extent, externally visible in the human face.34:Tb34,Abstract Background Looking older for one’s chronological age is associated with a higher mortality rate. Yet it remains unclear how perceived facial age relates to morbidity and the degree to which facial ageing reflects systemic ageing of the human body. Objectives To investigate the association between ΔPA and age-related morbidities of different organ systems, where ΔPA represents the difference between perceived age (PA) and chronological age. Methods We performed a cross-sectional analysis on data from the Rotterdam Study, a population-based cohort study in the Netherlands. High-resolution facial photographs of 2679 men and women aged 51.5–87.8 years of European descent were used to assess PA. PA was estimated and scored in 5-year categories using these photographs by a panel of men and women who were blinded for chronological age and medical history. A linear mixed model was used to generate the mean PAs. The difference between the mean PA and chronological age was calculated (ΔPA), where a higher (positive) ΔPA means that the person looks younger for their age and a lower (negative) ΔPA that the person looks older. ΔPA was tested as a continuous variable for association with ageing-related morbidities including cardiovascular, pulmonary, ophthalmological, neurocognitive, renal, skeletal and auditory morbidities in separate regression analyses, adjusted for age and sex (model 1) and additionally for body mass index, smoking and sun exposure (model 2). Results We observed 5-year higher ΔPA (i.e. looking younger by 5 years for one’s age) to be associated with less osteoporosis [odds ratio (OR) 0.76, 95% confidence interval (CI) 0.62–0.93], less chronic obstructive pulmonary disease (OR 0.85, 95% CI 0.77–0.95), less age-related hearing loss (model 2; B = −0.76, 95% CI −1.35 to −0.17) and fewer cataracts (OR 0.84, 95% CI 0.73–0.97), but with better global cognitive functioning (g-factor; model 2; B = 0.07, 95% CI 0.04–0.10). Conclusions PA is associated with multiple morbidities and better cognitive function, suggesting that systemic ageing and cognitive ageing are, to an extent, externally visible in the human face. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cataract: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Cataract (condition). Clinician-written summaries and actionable practice insights. 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Mean SEQ was −0.06 ± 0.30 D (EA) and 0.00 ± 0.32 D (ETA). No serious adverse events were documented.","limitations":"- No control group (e.g., standard monofocal IOL), so comparative efficacy for intermediate vision cannot be determined.\n- Convenience sampling by surgeons introduces selection bias; follow-up was short (up to ~4 months) and inconsistent across patients.\n- The Aspire IOL's effect on contrast sensitivity and visual disturbances (glare, halo) was not clinically evaluated, per the device labeling itself.","practice_takeaway":"Enhanced monofocal IOLs (enVista Aspire / Aspire Toric) delivered good distance and functional intermediate vision in routine cataract surgery, with 100% binocular UIVA ≥20/32. Clinicians should counsel patients that contrast sensitivity and dysphotopsia effects remain uncharacterized in formal clinical trials."}},{"doi":"10.1038/s41433-026-04796-4","pmid":"42649279","title":"Association of cardiovascular-kidney-metabolic syndrome with blinding eye diseases: insights from a UK Biobank cohort analysis","journal_title":"Eye","journal_issn":"0950-222X","published_at":"2026-08-26T00:00:00.000Z","url":"https://doi.org/10.1038/s41433-026-04796-4","source_score":11,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-02T06:22:27.519Z","updated_at":"2026-09-02T06:22:27.519Z","tags":[{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"condition","value":"Age-Related Macular Degeneration","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"condition","value":"Cardiovascular-Kidney-Metabolic Syndrome","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"condition","value":"Glaucoma","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"sample_size","value":"n=502376","value_numeric":502376},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"warning","value":"Sample size for the UK Biobank could not be confirmed from the abstract alone; the value used is the commonly reported total enrollment figure and may differ from the analytic sample.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"warning","value":"Stage 3 showed the highest absolute incidence rates, but it is unclear from the abstract whether stage 4 data showed attenuation or was underrepresented — clinicians should consult full results.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04796-4","tag_type":"warning","value":"The exact N for each CKM stage subgroup is not reported in the provided text, limiting precision of subgroup-level interpretation.","value_numeric":null}],"summaries":{"what_studied":"This UK Biobank cohort study examined whether cardiovascular-kidney-metabolic (CKM) syndrome — classified into five stages per American Heart Association criteria — is associated with incident cataract, glaucoma, and age-related macular degeneration (AMD) over more than 10 years of follow-up.","key_result":"Stage 3 CKM syndrome carried the highest risk for all three conditions vs. stage 0: cataract (HR 2.25, 95% CI 2.10–2.41), AMD (HR 2.08, 95% CI 1.76–2.46), and glaucoma (HR 1.76, 95% CI 1.51–2.05); absolute incidence rates peaked at stage 3, with 50,894 cataract, 11,518 glaucoma, and 8,708 AMD events recorded.","limitations":"Observational design limits causal inference; CKM staging was based on a single baseline assessment, which may not capture disease progression; UK Biobank participants skew healthier and less diverse than the general population (healthy volunteer bias).","practice_takeaway":"Patients with advanced CKM syndrome (especially stage 3) face roughly double the risk of cataract and AMD and 76% higher risk of glaucoma — clinicians managing cardiometabolic and kidney disease should incorporate routine eye screening into their care plans."}},{"doi":"10.1136/bjo-2026-329642","pmid":"42629173","title":"Association of fenofibrate use with progression of ocular disease in individuals with diabetes","journal_title":"British Journal of Ophthalmology","journal_issn":"0007-1161","published_at":"2026-08-21T00:00:00.000Z","url":"https://doi.org/10.1136/bjo-2026-329642","source_score":12,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-02T06:22:39.443Z","updated_at":"2026-09-02T06:22:39.443Z","tags":[{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"condition","value":"Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"condition","value":"Diabetic Macular Oedema","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"condition","value":"Diabetic Retinopathy","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"condition","value":"Primary Open Angle Glaucoma","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"generic","value":"fenofibrate","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"modality","value":"Fibrate","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"sample_size","value":"n=8632","value_numeric":8632},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"warning","value":"Fenofibrate dose, duration, and adherence data are not described; effect size estimates may not generalize across dosing regimens.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"warning","value":"No significant association was found for POAG, but the specific OR and confidence interval for POAG are not reported in the abstract — clinical interpretation for that outcome is limited.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"warning","value":"Sample size varies across the four outcome analyses (4073–4571 matched pairs each); the reported n=8632 reflects the largest cohort (VTDR). Readers should note each outcome used a separately matched population.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329642","tag_type":"warning","value":"The paper's publication date (2026-08-21) is in the near future relative to today; verify availability of the full text before clinical application.","value_numeric":null}],"summaries":{"practice_takeaway":"In diabetic patients with mild-to-moderate NPDR, fenofibrate use appears linked to roughly half the risk of retinopathy progression and DME — clinicians may consider fenofibrate as an adjunct to standard care, while awaiting confirmatory prospective trial data.","what_studied":"This retrospective cohort study used the TriNetX database (December 2014–December 2024) to examine whether fenofibrate use in adults (≥18 years) with diabetes and mild-to-moderate non-proliferative diabetic retinopathy (NPDR) was associated with lower rates of progression to vision-threatening DR (VTDR), diabetic macular oedema (DME), cataracts, or primary open-angle glaucoma (POAG), compared with matched non-users.","key_result":"After propensity score matching, fenofibrate use was associated with significantly lower odds of VTDR progression (OR 0.528, 95% CI 0.333–0.838; p=0.006), cataract development (OR 0.585, 95% CI 0.441–0.774; p=0.0002), and DME development (OR 0.316, 95% CI 0.243–0.411; p<0.0001); no significant association was found for POAG.","limitations":"- Retrospective database design limits causal inference; confounding by indication or unmeasured variables (e.g., lipid levels, glycemic control details, fenofibrate dose/duration) cannot be excluded.\n- ICD-10 code–based outcome definitions may misclassify disease severity or miss subclinical cases.\n- TriNetX captures healthcare encounters, so patients lost to follow-up or with incomplete records may introduce selection bias."}},{"doi":"10.1080/08820538.2026.2713201","pmid":"42623163","title":"Impact of Cataract Surgery Steps on Postoperative Dry Eye Disease: A Narrative Review","journal_title":"Seminars in Ophthalmology","journal_issn":"0882-0538","published_at":"2026-08-20T00:00:00.000Z","url":"https://doi.org/10.1080/08820538.2026.2713201","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-23T07:33:09.406Z","updated_at":"2026-08-23T07:33:09.406Z","tags":[{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"condition","value":"Dry Eye Disease","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"generic","value":"povidone-iodine","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"generic","value":"sodium hyaluronate","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"modality","value":"Ophthalmic Surgery","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"modality","value":"Topical Ophthalmic Agent","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"warning","value":"Age group inferred as 'older_adult' based on typical cataract surgery demographics; the paper does not explicitly state a target age group.","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"warning","value":"No sample size is reported — this is a narrative review with no primary patient data.","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"warning","value":"The effect of preoperative dilating drops on tear film stability is explicitly noted by the authors as unresolved.","value_numeric":null},{"paper_doi":"10.1080/08820538.2026.2713201","tag_type":"warning","value":"The impact_flag 'practice_changing' reflects actionable clinical guidance (preoperative screening, preservative-free regimens) from the review's conclusions, but is based on narrative rather than high-quality trial evidence.","value_numeric":null}],"summaries":{"what_studied":"This narrative review examined how each perioperative step of cataract surgery — preoperative, intraoperative, and postoperative — contributes to the development and severity of dry eye disease (DED).","key_result":"DED risk accumulates across the surgical episode: pre-existing (often undiagnosed) DED is common in cataract candidates; intraoperative factors (povidone-iodine, lid speculum, incision size/location, prolonged ocular exposure) and postoperative preserved-formulation drops (antibiotics, steroids, NSAIDs) each compound ocular surface disruption. Symptoms typically resolve within ~3 months, paralleling corneal nerve regeneration. Sodium hyaluronate and preservative-free drops improve postoperative tear film parameters.","limitations":"Narrative (non-systematic) review design limits reproducibility and introduces selection bias; no meta-analysis or pooled quantitative estimates are provided; effect of preoperative dilating drops on tear film stability remains unresolved.","practice_takeaway":"Screen cataract surgery candidates for DED before the procedure and treat pre-existing disease proactively. Favor preservative-free postoperative regimens and consider sodium hyaluronate to reduce postoperative DED burden."}},{"doi":"10.1136/bjo-2026-329580","pmid":"42618335","title":"Association of glaucoma and glaucoma treatments with cataract in the UK Biobank: a cross-sectional observational study","journal_title":"British Journal of Ophthalmology","journal_issn":"0007-1161","published_at":"2026-08-19T00:00:00.000Z","url":"https://doi.org/10.1136/bjo-2026-329580","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-22T06:53:36.843Z","updated_at":"2026-08-22T06:53:36.843Z","tags":[{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"condition","value":"Glaucoma","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"modality","value":"Glaucoma Surgery","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"modality","value":"Laser Procedure","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"modality","value":"Topical Ophthalmic Medication","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"sample_size","value":"n=497109","value_numeric":497109},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"warning","value":"Causality cannot be established from this cross-sectional design — the direction of association between glaucoma treatments and cataract is unclear.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"warning","value":"Glaucoma and cataract ascertainment combines self-report with ICD codes, introducing potential misclassification in both directions.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"warning","value":"The laser procedure subgroup estimate is unreliable due to small sample size and is excluded from the main conclusions.","value_numeric":null},{"paper_doi":"10.1136/bjo-2026-329580","tag_type":"warning","value":"UK Biobank participants are known to be healthier and less diverse than the general UK population, which may limit generalizability.","value_numeric":null}],"summaries":{"what_studied":"Cross-sectional analysis of 497,109 UK Biobank adults (recruited 2006–2010) examining whether glaucoma and its treatments — topical medications, laser procedures, or surgery — are independently associated with cataract odds after adjusting for demographics, clinical comorbidities, and ocular parameters.","key_result":"Glaucoma alone was associated with 3× higher cataract odds (OR 3.09, 95% CI 2.73–3.49). Topical glaucoma medications raised odds further (OR 3.14, 95% CI 2.54–3.89), while glaucoma surgery carried the highest odds (OR 12, 95% CI 8.99–16.2); all p<0.01.","limitations":"- Cross-sectional design prevents causal inference or temporal ordering of glaucoma, treatment, and cataract.\n- The first-line laser subgroup was too small for reliable adjusted estimates.\n- Glaucoma and cataract definitions relied partly on self-report, which may introduce misclassification.","practice_takeaway":"Patients with glaucoma — especially those who have had glaucoma surgery — face substantially higher cataract odds; clinicians should maintain active cataract surveillance in this group and consider the timing of cataract surgery accordingly."}},{"doi":"10.1016/j.ajo.2026.07.059","pmid":"42556630","title":"No-History IOL Power Calculation After Myopic Laser Vision Correction: A Multicenter Retrospective Database Study of 14 Formulas With and Without Posterior Corneal Curvature","journal_title":"American Journal of Ophthalmology","journal_issn":"0002-9394","published_at":"2026-08-06T00:00:00.000Z","url":"https://doi.org/10.1016/j.ajo.2026.07.059","source_score":3,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-11T13:26:09.415Z","updated_at":"2026-08-11T13:26:09.415Z","tags":[{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"brand","value":"IOLMaster 700","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"condition","value":"Post-Myopic Laser Vision Correction","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"generic","value":"Barrett True K Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"generic","value":"Cooke K6 Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"generic","value":"EVO 2.0 Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"generic","value":"PEARL-DGS Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"generic","value":"Shammas-Cooke Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"modality","value":"IOL Power Calculation Formula","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"modality","value":"Optical Biometry","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"sample_size","value":"n=3738","value_numeric":3738},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"study_design","value":"Retrospective Database Study","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"warning","value":"M-LVC history was based solely on surgeon report without independent verification; misclassification of eyes cannot be excluded.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"warning","value":"No pre-LVC biometry was available; all formulas evaluated are 'no-history' approaches only. Results may not generalize to history-based formula comparisons.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"warning","value":"The impact_flag 'practice_changing' was applied because this is the largest multicenter dataset comparing modern PCC vs. non-PCC formulas post-M-LVC, but gains in typical eyes are described as clinically negligible—clinicians should interpret context-dependently.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.07.059","tag_type":"warning","value":"The study is retrospective and limited to eyes with satisfactory postoperative visual acuity, which may introduce selection bias.","value_numeric":null}],"summaries":{"what_studied":"Retrospective multicenter comparison of 14 IOL power calculation formulas (with and without posterior corneal curvature [PCC] input) in 3,738 eyes with prior myopic laser vision correction (M-LVC) undergoing cataract surgery across U.S. centers (Oct 2017–Aug 2025), using IOLMaster 700 biometry and subjective refraction at 21–90 days postop.","key_result":"PCC-based formulas outperformed non-PCC counterparts (p <0.0001). Best PCC formulas: Cooke K6 (MAE 0.37 D), PEARL-DGS, EVO 2.0, and Barrett True K (all 0.38 D). Best non-PCC formulas: K6 and EVO 2.0 (both MAE 0.40 D). In short eyes (AL <23.5 mm) and steep corneas (K ≥43 D)—22% of the cohort—K6 gained >13% more eyes within ±0.50 D vs. Barrett True K; gains were clinically negligible in typical post-M-LVC eyes.","limitations":"- M-LVC history was surgeon-reported without independent verification, risking misclassification.\n- No pre-LVC biometry available; no-history formulas only.\n- Study limited to eyes with satisfactory postoperative visual acuity, potentially excluding poor outcomes.","practice_takeaway":"For post-myopic LVC cataract surgery, use PCC-capable modern formulas (K6, EVO 2.0, PEARL-DGS, or Barrett True K with PCC) when full biometry is available—especially in short eyes (AL <23.5 mm) or steep corneas (K ≥43 D). When full biometry is unavailable, Shammas-Cooke is a reasonable fallback."}},{"doi":"10.1038/s41433-026-04764-y","pmid":"42498775","title":"Square lens and cataract in a child with a de novo MAF gene mutation","journal_title":"Eye","journal_issn":"0950-222X","published_at":"2026-07-24T00:00:00.000Z","url":"https://doi.org/10.1038/s41433-026-04764-y","source_score":4,"is_retracted":false,"is_open_access":null,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":false},"created_at":"2026-07-31T13:37:00.736Z","updated_at":"2026-07-31T13:37:00.736Z","tags":[{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"condition","value":"Lens Dysmorphology","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"sample_size","value":"n=1","value_numeric":1},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"study_design","value":"Case Report","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"warning","value":"Full text was not available; summary is based solely on the paper metadata (title, journal, DOI). Specific mutation details, clinical measurements, and outcome data could not be verified.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04764-y","tag_type":"warning","value":"Study design classified as Case Report based on title context; this could not be confirmed from full text.","value_numeric":null}],"summaries":{"what_studied":"A pediatric case of square (quadrilateral) lens morphology and cataract associated with a de novo pathogenic variant in the MAF gene, a transcription factor linked to lens development.","key_result":"The child presented with a distinctively shaped 'square' lens and cataract attributed to a de novo MAF gene mutation, expanding the known phenotypic spectrum of MAF-associated ocular disease.","limitations":"Single case report limits generalizability; functional characterization of the specific mutation's mechanism was not reported.","practice_takeaway":"In children with unusual lens morphology or early-onset cataract of unclear cause, consider genetic testing for MAF mutations. De novo variants can occur without a family history, so a negative pedigree should not rule out a genetic etiology."}},{"doi":"10.1097/j.jcrs.0000000000002017","pmid":"42397104","title":"Light adjustable lens implantation with cataract surgery in eyes with macular pathology","journal_title":"Journal of Cataract & Refractive Surgery","journal_issn":"0886-3350","published_at":"2026-07-03T00:00:00.000Z","url":"https://doi.org/10.1097/j.jcrs.0000000000002017","source_score":5,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-18T13:39:51.668Z","updated_at":"2026-07-18T13:39:51.668Z","tags":[{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"brand","value":"Light Adjustable Lens","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"condition","value":"Age-Related Macular Degeneration","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"condition","value":"Epiretinal Membrane","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"condition","value":"Macular Pathology","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"modality","value":"Intraocular Lens Implantation","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"sample_size","value":"n=171","value_numeric":171},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"study_design","value":"Retrospective Case Series","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"warning","value":"No brand/generic name (RxNorm) is available for the Light Adjustable Lens beyond its trade designation; tagged under brand only.","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"warning","value":"The n=95 distance-targeted subgroup drives the headline visual acuity figures; outcomes for non-distance targets are not separately reported in the abstract.","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000002017","tag_type":"warning","value":"The sample pools heterogeneous macular diagnoses (ERM, dry AMD, other), so condition-specific conclusions should be drawn cautiously.","value_numeric":null}],"summaries":{"limitations":"Retrospective design with no control group limits causal inference. Mixed macular diagnoses (ERM, dry AMD, others) were pooled, which may obscure condition-specific outcomes. Private practice setting may limit generalizability.","what_studied":"Retrospective consecutive case series evaluating visual, refractive, and safety outcomes of the light adjustable lens (LAL) in 171 eyes (106 patients) with pre-existing macular pathology (epiretinal membrane, dry AMD/drusen, and other macular conditions) undergoing cataract surgery.","key_result":"Among distance-targeted eyes (n=95), 96% achieved UDVA of 20/25 or better and 85% achieved 20/20 or better post-adjustment. Refractive accuracy improved after the adjustment process: eyes within ±0.50 D rose from 66% to 87%, and those achieving 20/20 or better climbed from 26% to 85%.","practice_takeaway":"The LAL appears to be a viable premium IOL option even in patients with underlying macular disease — a group traditionally excluded from advanced IOL consideration. Clinicians may consider offering the LAL to appropriately counseled patients with ERM or dry AMD, given its post-implantation adjustability and strong refractive accuracy results."}},{"doi":"10.1016/j.ajo.2026.06.018","pmid":"42288324","title":"Noncombustible Nicotine or Tobacco Product Use after Smoking Cessation and Major Vision-Impairing Diseases: A Nationwide Cohort Study","journal_title":"American Journal of Ophthalmology","journal_issn":"0002-9394","published_at":"2026-06-14T00:00:00.000Z","url":"https://doi.org/10.1016/j.ajo.2026.06.018","source_score":11,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-23T13:25:13.076Z","updated_at":"2026-06-23T13:25:13.076Z","tags":[{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"condition","value":"Age-Related Macular Degeneration","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"condition","value":"Diabetic Retinopathy","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"condition","value":"Glaucoma","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"condition","value":"Refractive and Accommodation Disorders","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"modality","value":"Non-Combustible Nicotine or Tobacco Products","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"sample_size","value":"n=32316","value_numeric":32316},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"warning","value":"NNTPs are treated as a single category; findings may not apply equally to e-cigarettes, heated tobacco products, or smokeless tobacco individually.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"warning","value":"Study population is Korean adults only; results may not generalize to other ethnicities or healthcare systems.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"warning","value":"The diabetic retinopathy SHR upper CI bound just reaches 1.53 with a lower bound of exactly 1.00, indicating borderline statistical significance for that subgroup.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.06.018","tag_type":"warning","value":"The original cohort was 179,273; the matched analytic sample is 32,316 — the large reduction may affect generalizability and introduces potential selection bias from matching.","value_numeric":null}],"summaries":{"what_studied":"This retrospective cohort study compared the risk of major vision-impairing eye diseases (cataract, glaucoma, AMD, diabetic retinopathy, and refractive/accommodation disorders) among former smokers who switched to non-combustible nicotine or tobacco products (NNTPs) vs. those who completely quit all nicotine, using South Korean national insurance data with up to 6 years of follow-up.","key_result":"Among 32,316 propensity score–matched participants (mean follow-up 4.6 years), NNTP switchers had a modestly but significantly higher risk of vision-impairing eye disease vs. complete quitters (SHR 1.07; 95% CI 1.02–1.13; incidence 44.0 vs. 41.1 per 1,000 person-years). The largest effect was seen for diabetic retinopathy (SHR 1.24; 95% CI 1.00–1.53).","limitations":"- Observational design limits causal inference despite propensity score matching.\n- NNTP type (e-cigarettes, heated tobacco, smokeless tobacco) was not disaggregated, preventing product-specific conclusions.\n- Reliance on diagnostic codes may miss subclinical disease or introduce misclassification.","practice_takeaway":"When counseling patients on smoking cessation, ophthalmologists and primary care clinicians should not frame NNTP switching as visually safe — it carries a small but real increase in eye disease risk compared with quitting all nicotine entirely. Complete nicotine abstinence remains the preferred goal from an ophthalmic standpoint."}},{"doi":"10.1016/j.ajo.2026.05.037","pmid":"42242411","title":"INTRALENTICULAR VACUOLE MIMICKING A POSTERIOR POLAR CATARACT WITH POSTERIOR CAPSULE DEHISCENCE","journal_title":"American Journal of Ophthalmology","journal_issn":"0002-9394","published_at":"2026-06-03T00:00:00.000Z","url":"https://doi.org/10.1016/j.ajo.2026.05.037","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-10T14:24:07.338Z","updated_at":"2026-06-10T14:24:07.338Z","tags":[{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"condition","value":"Posterior Capsule Dehiscence","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"condition","value":"Posterior Polar Cataract","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"modality","value":"Ophthalmic Surgery","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"study_design","value":"Case Report","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"warning","value":"Full text of the paper was not available — key details such as patient demographics, imaging modalities used, surgical outcomes, and sample size could not be confirmed.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"warning","value":"No sample size tag applied as the number of cases reported could not be confirmed from available metadata alone.","value_numeric":null},{"paper_doi":"10.1016/j.ajo.2026.05.037","tag_type":"warning","value":"Study design tagged as Case Report based on the title and context; this should be verified against the full text.","value_numeric":null}],"summaries":{"what_studied":"A case report describing an intralenticular vacuole that mimicked the appearance of a posterior polar cataract with posterior capsule dehiscence, likely evaluating clinical and imaging findings to differentiate the two entities.","limitations":"Single case report with no comparative group; findings may not be generalizable; full text not available to confirm imaging modalities, outcomes, or surgical details.","practice_takeaway":"Clinicians should be aware that intralenticular vacuoles can closely mimic posterior polar cataracts with posterior capsule dehiscence — a distinction with significant surgical implications. Careful preoperative evaluation is warranted before assuming capsular compromise."}},{"doi":"10.1001/jamaophthalmol.2026.1471","pmid":"42166141","title":"Trypan Blue Use During Cataract Surgery and Postoperative Fungal Endophthalmitis","journal_title":"JAMA Ophthalmology","journal_issn":"2168-6165","published_at":"2026-05-21T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13195505/","source_score":17,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-12T13:24:25.382Z","updated_at":"2026-06-12T13:24:25.382Z","tags":[{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"condition","value":"Fungal Endophthalmitis","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"condition","value":"Postoperative Endophthalmitis","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"generic","value":"liposomal amphotericin B","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"generic","value":"trypan blue","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"generic","value":"voriconazole","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"modality","value":"Antifungal","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"modality","value":"Vitrectomy","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"sample_size","value":"n=6","value_numeric":6},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"study_design","value":"Retrospective Case Series","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"warning","value":"Full text is under embargo until May 21, 2027; summary is based solely on the published abstract. Some clinical details (e.g., trypan blue brand, exact contamination source investigation, susceptibility testing) may not be fully captured.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"warning","value":"Only 6 cases reported — findings reflect a localized outbreak and may not generalize to other settings or trypan blue products.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.1471","tag_type":"warning","value":"Trypan blue was used 'off-label' in these cases; the specific preparation or compounding source is not detailed in the abstract.","value_numeric":null}],"summaries":{"what_studied":"A retrospective case series of 6 patients who developed postoperative fungal endophthalmitis after cataract surgery using off-label trypan blue solution at 2 clinics in Japan in 2025, with referral to a single hospital for vitrectomy.","key_result":"All 6 cases were linked to *Sarocladium kiliense* contamination of the trypan blue solution. Infection was controlled in all eyes; mean BCVA improved from 1.77 logMAR (20/120) preoperatively to 0.26 logMAR (20/30) post-treatment. Two eyes required reoperation; 1 required IOL extraction.","limitations":"Very small case series (n=6) limits generalizability. Retrospective design with no control group. Full-text unavailable due to embargo — some methodological details may be missing from the abstract alone.","practice_takeaway":"Surgeons should be alert to clustered postoperative fungal endophthalmitis cases as a signal of possible surgical supply contamination, particularly with off-label adjuncts like trypan blue. Prompt vitrectomy combined with intravitreal and systemic voriconazole appears effective for *S. kiliense* endophthalmitis."}},{"doi":"10.1007/s44402-026-00107-2","pmid":"42154406","title":"A Survey of Hospital Optometrists Performing Ophthalmic Laser Procedures in the United Kingdom","journal_title":"Ophthalmic and Physiological Optics","journal_issn":"0275-5408","published_at":"2026-05-19T00:00:00.000Z","url":"https://doi.org/10.1007/s44402-026-00107-2","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-30T13:22:39.685Z","updated_at":"2026-05-30T13:22:39.685Z","tags":[{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"condition","value":"Glaucoma","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"modality","value":"Ophthalmic Laser Therapy","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"sample_size","value":"n=75","value_numeric":75},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"study_design","value":"Cross-Sectional Survey","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"warning","value":"No patient safety or outcomes data are reported; the clinical safety of autonomous optometrist laser practice cannot be assessed from this study alone.","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"warning","value":"Sample is drawn from a voluntary opt-in database, which may over-represent optometrists already active in laser practice and inflate autonomy estimates.","value_numeric":null},{"paper_doi":"10.1007/s44402-026-00107-2","tag_type":"warning","value":"The full text retrieved appears to be a 1999 Crown Report on prescribing reform, not the actual full text of the 2026 survey paper. Summaries and tags are based solely on the abstract and results sections provided, not the full article body.","value_numeric":null}],"summaries":{"what_studied":"A descriptive cross-sectional survey of 75 UK hospital optometrists who perform ophthalmic laser procedures, conducted over 6 weeks (May–June 2025), examining scope of practice, autonomy, and training.","key_result":"Over 90% of respondents work independently when performing laser procedures, averaging 5 h/week (±2). The most common procedures were Nd:YAG capsulotomy, selective laser trabeculoplasty (SLT), and peripheral laser iridotomy. Ninety percent trained via internal programmes. Years qualified was significantly associated with duration of laser practice (Fisher's exact test, p < 0.01); no independent predictors of scope or autonomy were found on multivariable logistic regression.","limitations":"Small, self-selected sample (n=75) drawn from a voluntary opt-in database and professional channels, risking response and selection bias. Cross-sectional design cannot establish causality. No data on patient outcomes or complication rates to assess safety of autonomous practice.","practice_takeaway":"Hospital optometrists are already performing laser procedures such as Nd:YAG capsulotomy and SLT autonomously across the UK, predominantly in cataract and glaucoma care. National clinical guidelines do not yet reflect this scope of practice and should be updated to align with current reality."}},{"doi":"10.1038/s41433-026-04527-9","pmid":"42129345","title":"Anterior capsular phimosis","journal_title":"Eye","journal_issn":"0950-222X","published_at":"2026-05-13T00:00:00.000Z","url":"https://doi.org/10.1038/s41433-026-04527-9","source_score":4,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-15T13:23:10.074Z","updated_at":"2026-05-17T13:21:39.105Z","tags":[{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"condition","value":"Anterior Capsular Phimosis","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"study_design","value":"Image/Case Report","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"Author contribution statements list initials (RMA, BRA, ND, SA) that do not correspond to the three named authors, which may indicate a template/copy-paste error in the publisher page metadata.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"It is unclear whether this is a review article, case series, or original research; study design tag has been omitted accordingly.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"Only bibliographic metadata was provided for this paper — no abstract, methods, results, or conclusions were included. No content-based summaries or tags can be generated. Please provide the full text or abstract for a complete extraction.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"Only the publisher landing page was available — full article text was not accessible. All structured fields requiring clinical content (what_studied, key_result, limitations, practice_takeaway) have been set to null as no study details, patient data, or findings could be verified.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"Study design, sample size, level of evidence, and drug/modality tags cannot be determined without access to the full text.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"The article is categorized as an 'Image' type in the journal, suggesting it is a brief clinical image submission rather than an original research study. Study design and level of evidence are assigned accordingly.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04527-9","tag_type":"warning","value":"The paper metadata provides only the title, journal, DOI, and publication date — no abstract, methods, results, or conclusions were supplied. All structured summary fields requiring specific study data (population, outcomes, limitations, takeaways) cannot be populated from the available information.","value_numeric":null}],"summaries":{"what_studied":"The paper addresses anterior capsular phimosis, a complication following cataract surgery in which the anterior capsule opening progressively contracts."}},{"doi":"10.1016/j.ophtha.2026.04.031","pmid":null,"title":"En Breve","journal_title":"Ophthalmology","journal_issn":"0161-6420","published_at":"2026-05-11T00:00:00.000Z","url":"https://doi.org/10.1016/j.ophtha.2026.04.031","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-05-20T13:23:24.201Z","updated_at":"2026-05-20T13:23:24.201Z","tags":[{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"brand","value":"Iluvien","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"condition","value":"Age-Related Macular Degeneration","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"condition","value":"Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"condition","value":"Diabetic Macular Edema","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"condition","value":"Diabetic Retinopathy","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"generic","value":"aflibercept","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"generic","value":"fluocinolone acetonide","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"modality","value":"Anti-VEGF Therapy","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"modality","value":"Artificial Intelligence","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"modality","value":"Corticosteroid Implant","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"study_design","value":"Summary / Overview of Multiple Studies","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"warning","value":"Brand name 'Iluvien' inferred for fluocinolone acetonide 0.19 mg intravitreal implant; not explicitly stated in the text.","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"warning","value":"Level of evidence assigned as '3' reflects the mix of designs across summarized studies (retrospective series, phase IV RCT, retrospective cohort, Delphi consensus); the RCT alone would rate higher.","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"warning","value":"Sample size tag reflects the largest single study (DR/mortality, n=524,687); other studies have much smaller cohorts.","value_numeric":null},{"paper_doi":"10.1016/j.ophtha.2026.04.031","tag_type":"warning","value":"This is a Spanish-language summary article ('En Breve') covering four separate linked studies; individual study details (page numbers, full datasets) are not available in this publisher page text.","value_numeric":null}],"summaries":{"what_studied":"This is a summary article ('En Breve') covering four studies published in the same issue of *Ophthalmology*: (1) intravitreal anti-VEGF injections and cataract risk (n=603), (2) fluocinolone acetonide implant vs. aflibercept for diabetic macular edema (n=306, phase IV RCT), (3) baseline diabetic retinopathy severity and mortality risk (n=524,687), and (4) a Delphi consensus on AI reference standards for age-related macular degeneration detection.","key_result":"- **Anti-VEGF & cataracts**: 10-year cumulative cataract surgery incidence was 40.7% in injected eyes vs. 7.2% in contralateral eyes; higher injection burden → higher risk.\n- **FAc implant (NEW DAY trial)**: Primary endpoint not met, but FAc reduced total intravitreal injections by ~50% vs. aflibercept monotherapy with similar visual/anatomic outcomes.\n- **DR severity & mortality**: 7.0% of 524,687 DM patients died over ~5 years; proliferative DR carried the highest mortality risk vs. DM without DR.\n- **AMD AI standard**: Beckman Classification established as the preferred Level 1 reference standard; volumetric OCT recommended as adjunct.","limitations":"- Anti-VEGF/cataract study: retrospective, single tertiary center, lens opacity grading only available at time of surgery, no standardized treatment protocol.\n- NEW DAY trial: primary endpoint not met; no cost-effectiveness analysis; IOP monitoring required with FAc.\n- DR/mortality study: findings may not generalize beyond US tertiary care systems; incomplete data on non-medical factors.\n- AMD Delphi: small expert panel (n=13); Beckman Classification may not be globally applicable.","practice_takeaway":"Clinicians giving repeated intravitreal anti-VEGF injections should counsel patients about a substantially elevated long-term cataract risk (~40% at 10 years). The FAc implant may be a viable baseline option for DME patients where reducing injection burden is a priority, but IOP monitoring is essential."}},{"doi":"10.1001/jamaophthalmol.2026.0845","pmid":"41989790","title":"Evaluating Metrics Assessing Surgical Success in Patients Undergoing Cataract Surgery","journal_title":"JAMA Ophthalmology","journal_issn":"2168-6165","published_at":"2026-04-17T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13087895/","source_score":19,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-19","doi":"10.1001/jamaophthalmol.2026.0845","days":"30","issn":"2168-6165","rank":"8","field":"Clinical Medicine","score":"19","category":"Ophthalmology","categories":["Ophthalmology"],"_categories":["Ophthalmology"]},"pubmed":{"doi":"10.1001/jamaophthalmol.2026.0845","title":"Evaluating Metrics Assessing Surgical Success in Patients Undergoing Cataract Surgery.","journal":"JAMA ophthalmology","methods":"","results":"A total of 55 132 patients underwent cataract surgery (mean [SD] age, 70.3 [9.3] years; 32 240 [58.5%] female; 1973 [3.6%] Asian American; 7053 [12.8%] Black; 1993 [3.6%] Hispanic; 42 178 [76.5%] White [race and ethnicity were self-reported]). Among all patients undergoing surgery, 49 979 (90.7%) achieved surgical success. Excluding patients with ocular comorbidities (25 563 patients [46.4%]), 28 242 of 29 569 (95.5%) achieved surgical success. Living in the least (vs most) affluent community (odds ratio [OR], 0.81; 95% CI, 0.72-0.91), undergoing complex surgery (OR, 0.82; 95% CI, 0.75-0.89) or a combination of cataract with another intraocular surgery (OR, 0.32; 95% CI, 0.29-0.35), and having diabetes (OR, 0.90; 95% CI, 0.84-0.98) were associated with lower odds of surgical success.","abstract":"$30","keywords":[],"pubmed_id":"41989790","conclusions":"","publication_date":"2026-04-17T00:00:00"},"crossref":{"DOI":"10.1001/jamaophthalmol.2026.0845","URL":"https://doi.org/10.1001/jamaophthalmol.2026.0845","ISSN":["2168-6165"],"link":[{"URL":"https://jamanetwork.com/journals/jamaophthalmology/articlepdf/2847385/jamaophthalmology_li_2026_oi_260017_1774891324.70911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Evaluating Metrics Assessing Surgical Success in Patients Undergoing Cataract Surgery"],"author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor"}]},{"given":"Dustin D.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Medical Social Science, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"VA Health Systems Research Center of Innovation for Complex Chronic Healthcare, Hines, Illinois"}]},{"given":"Azraa S.","family":"Chaudhury","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Weill Cornell Medicine, New York, New York"}]},{"given":"Sandeepkumar","family":"Gaddam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor"}]},{"given":"Chris A.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor"}]},{"given":"Shikha","family":"Marwah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor"}]},{"given":"Adovich S.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Medical Social Science, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}]},{"given":"Xueqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Medical Social Science, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}]},{"given":"Charlesnika T.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Medical Social Science, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}]},{"given":"Paul J.","family":"Bryar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}]},{"given":"Joshua D.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor"},{"name":"Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor"}]},{"given":null,"family":null,"sequence":"additional","affiliation":[]},{"given":"Sejal","family":"Amin","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Paul A.","family":"Edwards","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Divya","family":"Srikumaran","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Fasika","family":"Woreta","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Jeffrey S.","family":"Schultz","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Anurag","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Baseer","family":"Ahmad","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Alon","family":"Harris","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Vaidehi","family":"Dedania","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Paul J.","family":"Bryar","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Dustin D.","family":"French","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Michelle","family":"Hribar","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Merina","family":"Thomas","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Brian L.","family":"Vanderbeek","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Rithambara","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Suzann","family":"Pershing","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Sophia Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Preethi","family":"Ganapathy","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Michael","family":"Deiner","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Catherine","family":"Sun","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Anne E.","family":"Coleman","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Victoria","family":"Tseng","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Jennifer","family":"Patnaik","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Prem","family":"Subramanian","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Saleha","family":"Munir","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Wuqaas","family":"Munir","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Joshua D.","family":"Stein","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Lindsey","family":"DeLott","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Rajeev","family":"Ramchandran","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Ore-ofe","family":"Adesina","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Brian C.","family":"Stagg","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Barbara","family":"Wirostko","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Brian","family":"McMillian","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Arsham","family":"Sheybani","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Soshian","family":"Sarrapour","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) Consortium"}]},{"given":"Kristen","family":"Harris-Nwanyanwu","sequence":"additional","affiliation":[{"name":"for the Sight Outcomes Research Collaborative (SOURCE) 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However, 46.4% of patients were excluded by the metric due to ocular comorbidities—with older and Black patients disproportionately excluded. Lower community affluence (OR 0.81), complex surgery (OR 0.82), combined cataract+intraocular surgery (OR 0.32), and diabetes (OR 0.90) were each independently associated with lower odds of success.","limitations":"- Single metric focus (MIPS 191) limits generalizability to other quality measures.\n- Retrospective design with data from a collaborative registry may not reflect all practice settings.\n- Only the first operative eye was assessed for patients with bilateral surgery, potentially underrepresenting outcomes.","practice_takeaway":"Nearly half of cataract surgery patients are excluded from MIPS measure 191 due to ocular comorbidities, and older and Black patients are excluded at higher rates—raising fairness concerns when this metric is used for surgeon comparisons or reimbursement. Clinicians and policymakers should advocate for case-mix adjustment that accounts for sociodemographic and clinical factors before using this measure to judge performance."}},{"doi":"10.1097/j.jcrs.0000000000001906","pmid":"41664266","title":"Light-adjustable lens results of spherical equivalent and astigmatism correction from the U.S. Food and Drug Administration postapproval study","journal_title":"Journal of Cataract & Refractive Surgery","journal_issn":"0886-3350","published_at":"2026-02-10T00:00:00.000Z","url":"https://doi.org/10.1097/j.jcrs.0000000000001906","source_score":15,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-24T13:21:41.565Z","updated_at":"2026-06-24T13:21:41.565Z","tags":[{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"brand","value":"AcrySof IQ SN6AT","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"brand","value":"EnVista MX60ET","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"brand","value":"RxSight Light Adjustable Lens","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"condition","value":"Cataract","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"condition","value":"Corneal Astigmatism","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"generic","value":"light-adjustable intraocular lens","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"modality","value":"Intraocular Lens","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"modality","value":"Light-Adjustable Lens","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"modality","value":"Toric IOL","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"sample_size","value":"n=544","value_numeric":544},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"study_design","value":"Prospective Case Series with Comparator","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"warning","value":"Sample size of 544 is an aggregate across all three groups (LAL n=332, SN6AT n=111, MX60ET n=101); the LAL group is roughly 3× larger than each comparator, which may affect statistical comparisons.","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"warning","value":"Sex distribution was not reported in the available text; the 'mixed' sex tag is assumed based on typical cataract surgery populations.","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"warning","value":"Study design is labeled 'randomized prospective case series' in the abstract but comparisons are made against two separate external datasets, not randomized concurrent controls — level of evidence may be closer to 3 than 2.","value_numeric":null},{"paper_doi":"10.1097/j.jcrs.0000000000001906","tag_type":"warning","value":"The full text of the article was not accessible — only the abstract and results were available. Methodological details (e.g., inclusion/exclusion criteria, follow-up duration, statistical methods) could not be verified.","value_numeric":null}],"summaries":{"what_studied":"This study compared spherical equivalent (SEQ) and residual astigmatism outcomes in 332 adults receiving the light-adjustable lens (LAL) from the FDA postapproval study versus two contemporary toric IOL groups: AcrySof IQ SN6AT (n=111 eyes) and enVista MX60ET (n=101 eyes).","key_result":"LAL outperformed both toric IOLs: mean absolute error of residual astigmatism was 0.26 D (LAL) vs. 0.36 D (SN6AT) and 0.38 D (MX60ET); residual astigmatism ≤0.50 D achieved in 92.5% (LAL) vs. 76.6% (SN6AT) and 76.2% (MX60ET); SEQ within ≤0.50 D in 93.1% (LAL) vs. 83.8% (SN6AT) and 87.1% (MX60ET); UDVA was 20/19 (LAL) vs. 20/24 (SN6AT) and 20/25 (MX60ET).","limitations":"- The study design is a non-randomized comparison using separate historical/concurrent datasets, not a head-to-head RCT, limiting causal inference.\n- The toric IOL comparator groups differ in size and study origin, introducing potential selection and site-level biases.\n- The full text was not accessible; conclusions are drawn solely from the abstract and results sections.","practice_takeaway":"For cataract patients with preexisting corneal astigmatism, the LAL achieves meaningfully better refractive accuracy and uncorrected vision than standard toric IOLs — consider it when precision is the priority. 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Careful patient selection and tailored surgical planning are key to reduce risks such as rejection, glaucoma, and posterior capsular opacification."}},{"doi":"10.1093/bjd/ljac100","pmid":"36763776","title":"Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly","journal_title":"British Journal of Dermatology","journal_issn":"0007-0963","published_at":"2023-02-11T00:00:00.000Z","url":"https://doi.org/10.1093/bjd/ljac100","source_score":205,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2023-02-03","doi":"10.1093/bjd/ljac100","days":"30","issn":"0007-0963","rank":"1","field":"Clinical Medicine","score":"205","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1093/bjd/ljac100","title":"Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly.","journal":"The British journal of dermatology","methods":"","results":"We observed 5-year higher ΔPA (i.e. looking younger by 5 years for one's age) to be associated with less osteoporosis [odds ratio (OR) 0.76, 95% confidence interval (CI) 0.62-0.93], less chronic obstructive pulmonary disease (OR 0.85, 95% CI 0.77-0.95), less age-related hearing loss (model 2; B = -0.76, 95% CI -1.35 to -0.17) and fewer cataracts (OR 0.84, 95% CI 0.73-0.97), but with better global cognitive functioning (g-factor; model 2; B = 0.07, 95% CI 0.04-0.10).","abstract":"$33","keywords":[],"pubmed_id":"36763776","conclusions":"","publication_date":"2023-02-11T00:00:00"},"crossref":{"DOI":"10.1093/bjd/ljac100","URL":"https://doi.org/10.1093/bjd/ljac100","ISSN":["0007-0963","1365-2133"],"link":[{"URL":"https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljac100/48585062/ljac100.pdf","content-type":"application/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https://academic.oup.com/bjd/article-pdf/188/3/390/51919056/ljac100.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https://academic.oup.com/bjd/article-pdf/188/3/390/51919056/ljac100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"390-395","type":"journal-article","issue":"3","score":1,"title":["Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly"],"author":[{"given":"Selma","family":"Mekić","sequence":"first","affiliation":[{"name":"Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Luba M","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"David A","family":"Gunn","sequence":"additional","affiliation":[{"name":"Unilever Research and Development, Colworth Science Park , Sharnbrook MK44 1LQ , UK"}]},{"given":"Leonie C","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Merel A","family":"Hamer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"M Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Eline J","family":"Vinke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Meike W","family":"Vernooij","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Annet E G","family":"Haarman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Eric F","family":"Thee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Joelle E","family":"Vergroesen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Caroline C W","family":"Klaver","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Ophthalmology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Pauline H","family":"Croll","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Andre","family":"Goedegebure","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Katerina","family":"Trajanoska","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Fernando","family":"Rivadeneira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Joyce B J","family":"van Meurs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Banafsheh","family":"Arshi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Maryam","family":"Kavousi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Emmely W","family":"de Roos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}]},{"given":"Guy G O","family":"Brusselle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Respiratory Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Respiratory Medicine, Ghent University Hospital , Ghent , Belgium"}]},{"given":"Manfred ","family":"Kayser","sequence":"additional","affiliation":[{"name":"Department of Genetic Identification, Erasmus MC, University Medical Center Rotterdam , Rotterdam , the Netherlands"}]},{"given":"Tamar","family":"Nijsten","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the 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Disease","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"condition","value":"Cognitive Impairment","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"condition","value":"Osteoporosis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"sample_size","value":"n=2679","value_numeric":2679},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"warning","value":"Cross‑sectional associations only; incident disease risk and causality are not addressed.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"warning","value":"Definition of ΔPA appears inconsistent in the text (defined as perceived minus chronological age, yet a higher positive value is described as looking younger).","value_numeric":null},{"paper_doi":"10.1093/bjd/ljac100","tag_type":"warning","value":"Model details are partial (model 2 is specified for hearing loss and cognition but not for all outcomes).","value_numeric":null}],"summaries":{"what_studied":"Cross-sectional analysis of 2,679 adults (51.5–87.8 years) of European descent from the Rotterdam Study tested whether the difference between perceived and chronological age (ΔPA) relates to age‑related morbidities across organ systems. Perceived age was scored from facial photographs by blinded raters in 5‑year categories and associations were modeled with adjustments for age, sex, BMI, smoking, and sun exposure.","key_result":"Each 5‑year higher ΔPA (looking ~5 years younger) was associated with lower odds of osteoporosis (OR 0.76, 95% CI 0.62–0.93), COPD (OR 0.85, 95% CI 0.77–0.95), and cataracts (OR 0.84, 95% CI 0.73–0.97), less age‑related hearing loss (model 2; B = −0.76, 95% CI −1.35 to −0.17), and better global cognitive function (model 2; B = 0.07, 95% CI 0.04–0.10).","limitations":"Cross‑sectional design limits causal inference; all participants were of European descent, which may limit generalizability. Perceived age was panel‑scored in 5‑year bins, which may introduce measurement imprecision.","practice_takeaway":"In middle‑aged to older adults, looking younger for one’s age correlates with fewer age‑related conditions and better cognition; facial ageing may be a visible cue of systemic ageing burden. Use it, if at all, only as a prompt for appropriate evaluation, not as a basis for treatment decisions."}}],"initialOffset":18,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Cataract"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Cataract"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Cataract"}}}]]

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