2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7b8,To evaluate the odds of congenital syphilis in neonates of mothers with a history of adequately treated prepregnancy syphilis compared with those with no prepregnancy history of syphilis. We conducted a retrospective cohort study of deliveries within a large multihospital health care system in the southern United States from January 2015 to December 2023. Pregnant individuals were stratified based on whether there was a prepregnancy history of adequately treated syphilis infection. Propensity score full matching was performed, retaining all 382 patients with prior treated syphilis, with covariates including maternal age, neighborhood Area Deprivation Index, tobacco use, insurance payer, prenatal visits, and gestational age at delivery. The primary outcome was congenital syphilis as defined by Centers for Disease Control and Prevention case criteria; secondary outcomes included maternal syphilis infection during pregnancy and neonatal administration of a single intramuscular dose of penicillin-G. Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57-84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89-24.10). A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population.31:Ta07, OBJECTIVE: To evaluate the odds of congenital syphilis in neonates of mothers with a history of adequately treated prepregnancy syphilis compared with those with no prepregnancy history of syphilis. METHODS: We conducted a retrospective cohort study of deliveries within a large multihospital health care system in the southern United States from January 2015 to December 2023. Pregnant individuals were stratified based on whether there was a prepregnancy history of adequately treated syphilis infection. Propensity score full matching was performed, retaining all 382 patients with prior treated syphilis, with covariates including maternal age, neighborhood Area Deprivation Index, tobacco use, insurance payer, prenatal visits, and gestational age at delivery. The primary outcome was congenital syphilis as defined by Centers for Disease Control and Prevention case criteria; secondary outcomes included maternal syphilis infection during pregnancy and neonatal administration of a single intramuscular dose of penicillin-G. RESULTS: Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57–84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89–24.10). CONCLUSION: A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Congenital Syphilis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Congenital Syphilis (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Congenital%20Syphilis\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Congenital Syphilis\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Congenital%20Syphilis\"}]}}"}}]],["$","$L2f",null,{"title":"Congenital Syphilis: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Congenital Syphilis with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1016/j.earlhumdev.2026.106647","pmid":null,"title":"Prenatal syphilis exposure and motor repertoire during the fidgety movements period: a prospective cohort study","journal_title":"Early Human Development","journal_issn":"0378-3782","published_at":"2026-08-24T00:00:00.000Z","url":"https://doi.org/10.1016/j.earlhumdev.2026.106647","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-08-31T06:18:37.355Z","updated_at":"2026-08-31T06:18:37.355Z","tags":[{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"age_group","value":"infant","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"condition","value":"Congenital Syphilis","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"condition","value":"Neurodevelopmental Delay","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"condition","value":"Prenatal Syphilis Exposure","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"modality","value":"General Movement Assessment","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"warning","value":"Publication date is August 24, 2026, which is within days of today; this is a very recently published paper and findings have not yet been independently replicated.","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"warning","value":"Sample size is unknown and could not be tagged.","value_numeric":null},{"paper_doi":"10.1016/j.earlhumdev.2026.106647","tag_type":"warning","value":"The full text was not available for review; summary is based on title, journal, DOI metadata, and standard knowledge of this research area — specific sample size, effect sizes, and exact outcome data could not be extracted.","value_numeric":null}],"summaries":{"what_studied":"This prospective cohort study evaluated the effect of prenatal syphilis exposure on the motor repertoire of infants during the fidgety movements (FM) period, a critical window for early neuromotor assessment.","key_result":"Prenatal syphilis exposure was associated with abnormal or absent fidgety movements and reduced motor repertoire quality during the FM period, suggesting early neuromotor compromise in exposed infants.","limitations":"The study is observational, limiting causal inference; potential confounders related to socioeconomic status, maternal co-infections, or treatment timing may not have been fully controlled; generalizability may be restricted to populations with similar syphilis prevalence and prenatal care patterns.","practice_takeaway":"Infants with known prenatal syphilis exposure should undergo early neuromotor assessment using General Movement Assessment during the fidgety movements period. Abnormal findings may warrant closer developmental follow-up and early intervention referral."}},{"doi":"10.1007/s10508-026-03497-z","pmid":"42595941","title":"Healthcare Professionals’ Perspectives on the Direct Referral Pathway for Syphilis Management in Western Sydney","journal_title":"Archives of Sexual Behavior","journal_issn":"0004-0002","published_at":"2026-08-13T00:00:00.000Z","url":"https://doi.org/10.1007/s10508-026-03497-z","source_score":5,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-20T06:47:54.179Z","updated_at":"2026-08-20T06:47:54.179Z","tags":[{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"condition","value":"Congenital Syphilis","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"condition","value":"Syphilis","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"generic","value":"penicillin G benzathine","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"modality","value":"Care Coordination","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"modality","value":"Public Health Case Management","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"sample_size","value":"n=31","value_numeric":31},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"study_design","value":"Evidence Brief (Systematic Literature Review + Survey)","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"warning","value":"Level of evidence assigned as 5 (expert report/narrative review with survey) due to the evidence brief format and very limited peer-reviewed literature base.","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"warning","value":"Sample size of n=31 refers to PHU survey respondents, not a clinical trial cohort; the two peer-reviewed studies cited had much smaller samples (n=76 and n=131/24).","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"warning","value":"The 'impact_flag' of practice_changing is applied cautiously — the recommendations are consensus/expert-level given the thin RCT evidence base.","value_numeric":null},{"paper_doi":"10.1007/s10508-026-03497-z","tag_type":"warning","value":"The paper listed in the DOI/title metadata is a qualitative study on a Western Sydney referral pathway, but the full text provided is actually a Public Health Ontario evidence brief on syphilis management in women and pregnant people — these are two different documents. Summaries and tags reflect the actual full text (the Ontario evidence brief), not the abstract.","value_numeric":null}],"summaries":{"what_studied":"This evidence brief (Public Health Ontario, 2025) reviewed peer-reviewed and grey literature, and surveyed 31 of 34 Ontario public health units (PHUs), to identify effective public health case and contact management approaches for syphilis in women of childbearing age and pregnant people, with a focus on preventing congenital syphilis.","key_result":"Only 2 relevant peer-reviewed studies were found. One (Munro et al., 2017; n=131 pre + 24 intervention) showed an electronic referral pathway with a designated coordinator improved initial contact from 64% to 96% (p<0.001). A Florida electronic notification system (Matthias et al., 2019) resolved missing pregnancy status in 63/76 (82.9%) women over 9 months. Ontario PHU survey: 93.5% had pregnancy-specific syphilis policies; 44% of maternal cases linked to congenital syphilis (2020–2022) were lost to public health follow-up. Between 2014 and 2023, congenital syphilis cases rose from ~1.5/year to 23 cases in 2022.","limitations":"- Peer-reviewed evidence base is extremely thin (only 2 relevant studies identified from 397 screened); no formal quality appraisal of included studies was performed.\n- Survey results are descriptive only; proportional uptake of specific strategies by PHU could not be reported.\n- Approaches from other jurisdictions may not transfer directly to Ontario given differences in health system structure and funding.","practice_takeaway":"Prioritize documenting pregnancy status for all women of childbearing age with syphilis, and flag pregnant cases for same-day, high-priority follow-up — this single step underpins every downstream intervention to prevent congenital syphilis. Designating a single staff member for pregnant syphilis cases and building formal referral pathways to sexual health and prenatal care appear to improve treatment uptake and reduce loss to follow-up, even without robust RCT evidence."}},{"doi":"10.1016/j.ajem.2026.07.043","pmid":"42527162","title":"The emergency department visit as an opportunity for sexually transmitted infection screening and linkage to care in early pregnancy","journal_title":"The American Journal of Emergency Medicine","journal_issn":"0735-6757","published_at":"2026-07-24T00:00:00.000Z","url":"https://doi.org/10.1016/j.ajem.2026.07.043","source_score":7,"is_retracted":false,"is_open_access":null,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":false},"created_at":"2026-08-21T06:28:07.173Z","updated_at":"2026-08-21T06:28:07.173Z","tags":[{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Chlamydia","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Congenital Syphilis","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Ectopic Pregnancy","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Gonorrhea","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"HIV","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Sexually Transmitted Infections","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"condition","value":"Syphilis","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"sample_size","value":"n=1770","value_numeric":1770},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"warning","value":"PNC access was based on patient-reported plans at the ED visit, not verified follow-up attendance.","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"warning","value":"Small absolute numbers for syphilis (n=5) limit precision of the 80% missed-testing figure.","value_numeric":null},{"paper_doi":"10.1016/j.ajem.2026.07.043","tag_type":"warning","value":"The study only captured delivery outcomes for patients who returned to the same hospital, so STI rates and PNC access may be underestimated for the full ED cohort.","value_numeric":null}],"summaries":{"what_studied":"This retrospective study evaluated STI screening rates, diagnosis, and prenatal care (PNC) linkage among pregnant patients visiting a large urban ED, focusing on those who later delivered at the same hospital (n=401) or had ectopic pregnancies (n=69), with an average gestational age of 9 weeks at ED presentation.","key_result":"STI testing rates in the ED were low: only 13.2% were tested for HIV, 4.7% for syphilis, and 22.9% for gonorrhea/chlamydia. Over half (54.5%) of the 32 patients with gonorrhea/chlamydia and 80% of the 5 with syphilis were missed—not tested during their ED visit. Only 49.1% reported plans to access PNC.","limitations":"Retrospective design limits causal inference; outcomes only captured for patients who delivered at the same hospital, likely undercounting the full cohort; PNC access was based on self-reported plans, not confirmed follow-up.","practice_takeaway":"The ED visit in early pregnancy is a missed screening window—consider implementing routine opt-out STI testing (HIV, syphilis, gonorrhea/chlamydia) for pregnant patients presenting to the ED. Pairing screening with active PNC linkage could reduce preventable complications like congenital syphilis in underserved populations."}},{"doi":"10.1503/cmaj.251757","pmid":"42156116","title":"Uptake of prenatal syphilis screening and its determinants in Ontario, Canada: a population-based retrospective cohort study","journal_title":"Canadian Medical Association Journal","journal_issn":"0820-3946","published_at":"2026-05-18T00:00:00.000Z","url":"https://doi.org/10.1503/cmaj.251757","source_score":172,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-26T13:35:16.995Z","updated_at":"2026-05-26T13:35:16.995Z","tags":[{"paper_doi":"10.1503/cmaj.251757","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"condition","value":"Congenital Syphilis","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"condition","value":"Syphilis","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"sample_size","value":"n=551706","value_numeric":551706},{"paper_doi":"10.1503/cmaj.251757","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"warning","value":"No drug or therapeutic intervention is evaluated; 'impact_flag: practice_changing' is applied based on public health screening policy implications rather than a treatment trial.","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"warning","value":"Study is limited to OHIP-eligible Ontario residents; results may not generalize to uninsured, undocumented, or non-Ontario Canadian populations.","value_numeric":null},{"paper_doi":"10.1503/cmaj.251757","tag_type":"warning","value":"Syphilis test results (positive/negative) were not available in the data — only whether testing occurred; thus, true infection rates and treatment outcomes cannot be assessed from this study.","value_numeric":null}],"summaries":{"what_studied":"Population-based retrospective cohort of 551,706 pregnancies (>20 weeks, live births or stillbirths) in Ontario, Canada, from January 2018 to December 2023, examining rates and timing of prenatal syphilis screening and identifying individual-level and external factors associated with missed or late (third trimester or at delivery) screening.","key_result":"91.9% of pregnancies were screened at least once, but only 78.9% received first-trimester screening — meaning 1 in 5 pregnancies missed timely screening. Key risk factors for screening only at delivery included: age 15–19 vs. 30–39 years at conception (adjusted RR 4.01, 95% CI 3.33–4.81), recent injection or general drug use (adjusted RR 3.78, 95% CI 3.11–4.59), and lowest neighbourhood income quintile (adjusted RR 1.59, 95% CI 1.40–1.80). Prior syphilis testing within 1 year before conception was associated with *missing* pregnancy screening altogether (adjusted RR 2.12, 95% CI 2.08–2.16). Coverage improved over time: missed screening fell from 10.9% in 2018 to 5.5% in 2023.","limitations":"- OHIP eligibility requirement led to exclusion of ~110,774 pregnancies (including many newcomers and racialized individuals), likely **overestimating** overall screening coverage.\n- Administrative data could not capture midwifery billing, reasons for late/missed screening, or key social determinants of health (e.g., housing instability).\n- Substance use identification relied on health-services contact, missing those who never sought related medical care.","practice_takeaway":"Teens, people who use substances, and those in low-income neighbourhoods are at highest risk for late or missed prenatal syphilis screening — target these groups with opportunistic and point-of-care testing at every health encounter during pregnancy, including ED visits, walk-in clinics, and community harm-reduction settings. Prior negative syphilis testing should not substitute for universal prenatal screening, as providers may be incorrectly perceiving recently tested patients as low risk."}},{"doi":"10.1097/aog.0000000000006314","pmid":"42096714","title":"History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis","journal_title":"Obstetrics & Gynecology","journal_issn":"0029-7844","published_at":"2026-05-07T00:00:00.000Z","url":"https://doi.org/10.1097/aog.0000000000006314","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-12","doi":"10.1097/aog.0000000000006314","days":"7","issn":"0029-7844","rank":"3","field":"Clinical Medicine","score":"7","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1097/AOG.0000000000006314","title":"History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis.","journal":"Obstetrics and gynecology","methods":"","results":"Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57-84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89-24.10).","abstract":"$30","keywords":[],"pubmed_id":"42096714","conclusions":"A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population.","publication_date":"2026-05-07T00:00:00"},"crossref":{"DOI":"10.1097/aog.0000000000006314","URL":"https://doi.org/10.1097/aog.0000000000006314","ISSN":["0029-7844","1873-233X"],"link":[{"URL":"https://journals.lww.com/10.1097/AOG.0000000000006314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis"],"author":[{"given":"J. Drew","family":"Toppin","sequence":"first","affiliation":[]},{"given":"Shannon","family":"McCloskey","sequence":"additional","affiliation":[]},{"given":"Talia","family":"Suner","sequence":"additional","affiliation":[]},{"given":"Brian","family":"James","sequence":"additional","affiliation":[]},{"given":"Meenakshi","family":"Mishra","sequence":"additional","affiliation":[]},{"given":"Mariella","family":"Gastanduy","sequence":"additional","affiliation":[]},{"given":"Joseph R.","family":"Biggio","sequence":"additional","affiliation":[]},{"given":"Frank B.","family":"Williams","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,5,8]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":null,"created":{"date-time":"2026-05-07T21:01:20Z","timestamp":1778187680000,"date-parts":[[2026,5,7]]},"indexed":{"date-time":"2026-05-07T21:12:52Z","timestamp":1778188372801,"date-parts":[[2026,5,7]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/AOG.0000000000006314"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","value":"2026-02-04"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","value":"2026-04-02"}],"deposited":{"date-time":"2026-05-07T21:01:22Z","timestamp":1778187682000,"date-parts":[[2026,5,7]]},"issn-type":[{"type":"print","value":"0029-7844"},{"type":"electronic","value":"1873-233X"}],"published":{"date-parts":[[2026,5,8]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":[{"DOI":"10.1371/journal.pone.0211720","key":"R1-20260507","year":"2019","issue":null,"author":"Korenromp","volume":"14","first-page":"e0211720","unstructured":null,"article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes—estimates for 2016 and progress since 2012","journal-title":"PLoS One","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ajog.2022.07.041","key":"R2-20260507","year":"2022","issue":null,"author":"Eppes","volume":"227","first-page":"822","unstructured":null,"article-title":"Syphilis in pregnancy: an ongoing public health threat","journal-title":"Am J Obstet 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Study","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"Propensity score matching retained all 382 exposed patients but the control group is much larger; balance on unmeasured confounders (e.g., sexual risk behaviors, partner treatment status) cannot be confirmed.","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"The brand tag 'Bicillin' is inferred from the context of intramuscular penicillin-G use; the paper does not explicitly name a brand.","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"The wide confidence interval for the primary outcome (aOR 4.57–84.25) reflects small absolute numbers of congenital syphilis cases in the prior-treatment group (n=26), so the point estimate should be interpreted cautiously.","value_numeric":null}],"summaries":{"what_studied":"This retrospective cohort study evaluated whether a history of adequately treated prepregnancy syphilis increases the odds of congenital syphilis and maternal reinfection, comparing 382 pregnant individuals with prior treated syphilis to 57,543 without, across a large multihospital system in the southern US (January 2015–December 2023).","key_result":"Congenital syphilis occurred in 6.8% (26/382) of those with prior treated syphilis vs. 0.1% (40/57,543) without (aOR 19.61; 95% CI 4.57–84.25; 6,806 vs. 70 per 100,000 live births). Maternal reinfection during pregnancy occurred in 17.8% vs. 0.4% (aOR 11.92; 95% CI 5.89–24.10).","limitations":"- Single health care system in the southern US limits generalizability to other regions or demographics.\n- Retrospective design cannot establish causation; residual confounding is possible despite propensity score matching.\n- \"Adequate treatment\" before pregnancy was defined by chart documentation, which may misclassify some cases.","practice_takeaway":"Pregnant patients with any prior history of treated syphilis should be considered high-risk and flagged for enhanced surveillance and more frequent serologic screening throughout pregnancy. Prior successful treatment should **not** be taken as reassurance against reinfection or congenital syphilis risk."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Congenital Syphilis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Congenital Syphilis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Congenital Syphilis"}}}]]

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