2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T49a,The search yielded 96 studies (1954-2025) documenting 134 patients. The number of reports has notably increased since the 21st century; however, diagnosis remains challenging due to possible dermatophyte adaptation in the dermal/subcutaneous environment. Trichophyton rubrum is the most frequently isolated pathogen. Acquired immunodeficiencies (e.g. renal transplant recipients) and primary immunodeficiencies (e.g. CARD9, STAT3 mutations) elevate the risk of deep dermatophytosis. Systemic dissemination, often accompanied by lymphadenopathy, was reported in 24 patients, with the most common being infection of the axillary and inguinal lymph nodes. Infections of the bones, lungs, and brain were also reported. Terbinafine (125-1000 mg/day) and itraconazole (100-400 mg/day), with adjunctive topical antifungals and surgical interventions, have been tried for deep dermatophytosis. The use of newer triazoles (voriconazole, posaconazole) should follow the principles of antifungal stewardship and therapeutic drug monitoring recommendations. Multidrug resistance is a potential concern in immunocompromised patients who will often require extended or lifelong treatment.31:T89b,Dermatophytes-a group of obligate keratinophilic fungi that infect the skin, hair and nails-represent the most common cause of fungal infections worldwide. In immunocompromised individuals, a growing body of literature has documented rare instances of dermatophyte infections of the dermis and subcutaneous tissue, which can lead to deep dermatophytosis with systemic dissemination and pseudomycetoma as secondary complications. To assess patient characteristics, risk factors, diagnostic evidence and treatment options for deep dermatophytosis. A systematic review was conducted in June 2025 to identify patients presenting with deep dermatophytosis of the glabrous skin; all cases were validated by confirmatory testing per histopathologic examination and fungal culture. Majocchi's granuloma diagnoses were excluded. The search yielded 96 studies (1954-2025) documenting 134 patients. The number of reports has notably increased since the 21st century; however, diagnosis remains challenging due to possible dermatophyte adaptation in the dermal/subcutaneous environment. Trichophyton rubrum is the most frequently isolated pathogen. Acquired immunodeficiencies (e.g. renal transplant recipients) and primary immunodeficiencies (e.g. CARD9, STAT3 mutations) elevate the risk of deep dermatophytosis. Systemic dissemination, often accompanied by lymphadenopathy, was reported in 24 patients, with the most common being infection of the axillary and inguinal lymph nodes. Infections of the bones, lungs, and brain were also reported. Terbinafine (125-1000 mg/day) and itraconazole (100-400 mg/day), with adjunctive topical antifungals and surgical interventions, have been tried for deep dermatophytosis. The use of newer triazoles (voriconazole, posaconazole) should follow the principles of antifungal stewardship and therapeutic drug monitoring recommendations. Multidrug resistance is a potential concern in immunocompromised patients who will often require extended or lifelong treatment. Healthcare providers should be cognizant that dermatophytosis may become invasive and disseminated in immunocompromised populations. Testing and early treatment should not be overlooked in these patients.32:Ta45,AbstractBackgroundDermatophytes—a group of obligate keratinophilic fungi that infect the skin, hair and nails—represent the most common cause of fungal infections worldwide. In immunocompromised individuals, a growing body of literature has documented rare instances of dermatophyte infections of the dermis and subcutaneous tissue, which can lead to deep dermatophytosis with systemic dissemination and pseudomycetoma as secondary complications.ObjectivesTo assess patient characteristics, risk factors, diagnostic evidence and treatment options for deep dermatophytosis.MethodsA systematic review was conducted in June 2025 to identify patients presenting with deep dermatophytosis of the glabrous skin; all cases were validated by confirmatory testing per histopathologic examination and fungal culture. Majocchi's granuloma diagnoses were excluded.ResultsThe search yielded 96 studies (1954–2025) documenting 134 patients. The number of reports has notably increased since the 21st century; however, diagnosis remains challenging due to possible dermatophyte adaptation in the dermal/subcutaneous environment. Trichophyton rubrum is the most frequently isolated pathogen. Acquired immunodeficiencies (e.g. renal transplant recipients) and primary immunodeficiencies (e.g. CARD9, STAT3 mutations) elevate the risk of deep dermatophytosis. Systemic dissemination, often accompanied by lymphadenopathy, was reported in 24 patients, with the most common being infection of the axillary and inguinal lymph nodes. Infections of the bones, lungs, and brain were also reported. Terbinafine (125–1000 mg/day) and itraconazole (100–400 mg/day), with adjunctive topical antifungals and surgical interventions, have been tried for deep dermatophytosis. The use of newer triazoles (voriconazole, posaconazole) should follow the principles of antifungal stewardship and therapeutic drug monitoring recommendations. Multidrug resistance is a potential concern in immunocompromised patients who will often require extended or lifelong treatment.ConclusionsHealthcare providers should be cognizant that dermatophytosis may become invasive and disseminated in immunocompromised populations. Testing and early treatment should not be overlooked in these patients.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Deep Dermatophytosis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Deep Dermatophytosis (condition). Clinician-written summaries and actionable practice insights. 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dermatophytosis of the stratum lucidum: is the epidermal location of dermatophyte infection evolving?","journal-title":"Skinmed","doi-asserted-by":null},{"DOI":"10.1111/myc.70081","key":"e_1_2_12_7_1","year":"2025","issue":"6","author":"Liu H","volume":"68","first-page":null,"unstructured":null,"article-title":"Biologic therapy and superficial fungal infection risk in moderate‐to‐severe psoriasis: a meta‐analysis","journal-title":"Mycoses","doi-asserted-by":"crossref"},{"DOI":"10.1097/00001432-200404000-00002","key":"e_1_2_12_8_1","year":"2004","issue":"2","author":"Hay RJ","volume":"17","first-page":"77","unstructured":null,"article-title":"Deep dermatophytosis: rare infections or common, but unrecognised, complications of lymphatic spread?","journal-title":"Curr Opin Infect Dis","doi-asserted-by":"crossref"},{"DOI":"10.3390/jof2010004","key":"e_1_2_12_9_1","year":"2015","issue":"1","author":"Rouzaud C","volume":"2","first-page":null,"unstructured":null,"article-title":"Severe 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deficiency","journal-title":"J Clin Immunol","doi-asserted-by":"crossref"},{"DOI":"10.1016/0190-9622(95)90270-8","key":"e_1_2_12_41_1","year":"1995","issue":"2","author":"Grossman ME","volume":"33","first-page":"315","unstructured":null,"article-title":"Invasive Trichophyton rubrum infection in the immunocompromised host: report of three cases","journal-title":"J Am Acad Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1007/s40257-017-0309-6","key":"e_1_2_12_42_1","year":"2017","issue":"5","author":"González‐Cantero Á","volume":"18","first-page":"709","unstructured":null,"article-title":"Comment on: “A unique clinicopathological manifestation of fungal infection: a case series of deep dermatophytosis in immunosuppressed patients”","journal-title":"Am J Clin Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1001/archderm.1983.01650300036013","key":"e_1_2_12_43_1","year":"1983","issue":"6","author":"Hironaga 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effect estimates are descriptive and non-comparative.","value_numeric":null},{"paper_doi":"10.1111/jdv.70115","tag_type":"warning","value":"The review excludes Majocchi's granuloma; ensure diagnostic criteria align when applying these data.","value_numeric":null},{"paper_doi":"10.1111/jdv.70115","tag_type":"warning","value":"Treatment response rates reflect reported outcomes and may be influenced by reporting bias and variable follow-up.","value_numeric":null}],"summaries":{"what_studied":"A systematic review (search June 2025) of histopathology- and culture-confirmed deep dermatophytosis of glabrous skin, excluding Majocchi's granuloma; 96 studies from 1954–2025 describing 134 patients.","key_result":"Median age was 51 years (IQR 22); 70.1% (94/134) were male, and Trichophyton rubrum was most frequent. Dissemination occurred in 24/134 patients (lymph node involvement confirmed in 15), with bone (5 cases) and brain abscesses (4 cases) reported; among therapies, improvement was reported with terbinafine in 64.8% (35/54), itraconazole in 46.5% (33/71), posaconazole in 58.8% (10/17), and voriconazole in 38.5% (5/13).","limitations":"Most included reports were case reports or small series, creating publication bias; antifungal susceptibility testing and therapeutic drug monitoring data were sparse, and some treatment data were incompletely reported.","practice_takeaway":"In immunocompromised patients with atypical nodules, ulcers, abscesses, or lymphadenopathy, obtain histopathology and culture to diagnose deep dermatophytosis and treat concomitant superficial tinea to reduce autoinoculation risk. Oral terbinafine or itraconazole are commonly used; if newer triazoles are needed, follow antifungal stewardship with therapeutic drug monitoring and watch for drug–drug interactions."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Deep Dermatophytosis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Deep Dermatophytosis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Deep Dermatophytosis"}}}]]

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