2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T495,Among 11 patients with T indotineae (6 male and 5 female patients; median [range] age, 39 [10-65] years), 2 were pregnant; 1 had lymphoma; and the remainder were immunocompetent. Nine patients reported previous travel to Bangladesh. All had widespread lesions with variable scale and inflammation, topical antifungal monotherapy failure, and diagnostic delays (range, 3-42 months). Terbinafine treatment failed in 7 patients at standard doses (250 mg daily) for prolonged duration; these patients also had isolates with amino acid substitutions at positions 393 (L393S) or 397 (F397L) in squalene epoxidase that correlated with elevated terbinafine minimum inhibitory concentrations of 0.5 μg/mL or higher. Patients who were treated with fluconazole and griseofulvin improved in 2 of 4 and 2 of 5 instances, respectively, without correlation between outcomes and antifungal minimum inhibitory concentrations. Furthermore, 5 of 7 patients treated with itraconazole cleared or had improvement at the last follow-up, and 2 of 7 were lost to follow-up or stopped treatment. Based on whole-genome sequencing analysis, US isolates formed a cluster distinct from Indian isolates.31:T958,Trichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on infections with T indotineae are sparse and could improve treatment practices and medical understanding of transmission. To correlate clinical features of T indotineae infections with in vitro antifungal susceptibility testing results, squalene epoxidase gene sequence variations, and isolate relatedness using whole-genome sequencing. This retrospective cohort study of patients with T indotineae infections in New York City spanned May 2022 to May 2023. Patients with confirmed T indotineae infections were recruited from 6 New York City medical centers. Improvement or resolution at the last follow-up assessment. Among 11 patients with T indotineae (6 male and 5 female patients; median [range] age, 39 [10-65] years), 2 were pregnant; 1 had lymphoma; and the remainder were immunocompetent. Nine patients reported previous travel to Bangladesh. All had widespread lesions with variable scale and inflammation, topical antifungal monotherapy failure, and diagnostic delays (range, 3-42 months). Terbinafine treatment failed in 7 patients at standard doses (250 mg daily) for prolonged duration; these patients also had isolates with amino acid substitutions at positions 393 (L393S) or 397 (F397L) in squalene epoxidase that correlated with elevated terbinafine minimum inhibitory concentrations of 0.5 μg/mL or higher. Patients who were treated with fluconazole and griseofulvin improved in 2 of 4 and 2 of 5 instances, respectively, without correlation between outcomes and antifungal minimum inhibitory concentrations. Furthermore, 5 of 7 patients treated with itraconazole cleared or had improvement at the last follow-up, and 2 of 7 were lost to follow-up or stopped treatment. Based on whole-genome sequencing analysis, US isolates formed a cluster distinct from Indian isolates. The results of this case series suggest that disease severity, diagnostic delays, and lack of response to typically used doses and durations of antifungals for tinea were common in this primarily immunocompetent patient cohort with T indotineae, consistent with published data. Itraconazole was generally effective, and the acquisition of infection was likely in Bangladesh.32:Tc6d,ImportanceTrichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on infections with T indotineae are sparse and could improve treatment practices and medical understanding of transmission.ObjectiveTo correlate clinical features of T indotineae infections with in vitro antifungal susceptibility testing results, squalene epoxidase gene sequence variations, and isolate relatedness using whole-genome sequencing.Design, Setting, and ParticipantsThis retrospective cohort study of patients with T indotineae infections in New York City spanned May 2022 to May 2023. Patients with confirmed T indotineae infections were recruited from 6 New York City medical centers.Main Outcome and MeasureImprovement or resolution at the last follow-up assessment.ResultsAmong 11 patients with T indotineae (6 male and 5 female patients; median [range] age, 39 [10-65] years), 2 were pregnant; 1 had lymphoma; and the remainder were immunocompetent. Nine patients reported previous travel to Bangladesh. All had widespread lesions with variable scale and inflammation, topical antifungal monotherapy failure, and diagnostic delays (range, 3-42 months). Terbinafine treatment failed in 7 patients at standard doses (250 mg daily) for prolonged duration; these patients also had isolates with amino acid substitutions at positions 393 (L393S) or 397 (F397L) in squalene epoxidase that correlated with elevated terbinafine minimum inhibitory concentrations of 0.5 μg/mL or higher. Patients who were treated with fluconazole and griseofulvin improved in 2 of 4 and 2 of 5 instances, respectively, without correlation between outcomes and antifungal minimum inhibitory concentrations. Furthermore, 5 of 7 patients treated with itraconazole cleared or had improvement at the last follow-up, and 2 of 7 were lost to follow-up or stopped treatment. Based on whole-genome sequencing analysis, US isolates formed a cluster distinct from Indian isolates.Conclusion and RelevanceThe results of this case series suggest that disease severity, diagnostic delays, and lack of response to typically used doses and durations of antifungals for tinea were common in this primarily immunocompetent patient cohort with T indotineae, consistent with published data. Itraconazole was generally effective, and the acquisition of infection was likely in Bangladesh.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Dermatophytosis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Dermatophytosis (condition). Clinician-written summaries and actionable practice insights. 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PCR was positive in 54/85 (63.5%), NGS in 6/85 (7.06%), and only 3/56 (5.36%) test-positive animals had skin lesions. Six animals had compatible lesions but tested negative on all assays. No abnormal trichogram findings were observed.","limitations":"- Single geographic region (Southern California) limits generalizability.\n- Cross-sectional design with no follow-up; subclinical carriers were not re-tested.\n- Poor inter-test agreement makes it difficult to define a true 'gold standard' for dermatophytosis diagnosis in this species.","practice_takeaway":"Routine culture remains the most clinically meaningful test; a positive PCR alone likely reflects environmental exposure rather than active infection in guinea pigs. Clinicians should interpret molecular results alongside clinical signs—and not assume a lesion-free animal is infection-free."}},{"doi":"10.3201/eid3209.260463","pmid":"42661283","title":"Global Spread of\n Trichophyton indotineae\n Tracked by Mass Spectrometry Identification Network, 2022–2025","journal_title":"Emerging Infectious Diseases","journal_issn":"1080-6040","published_at":"2026-08-17T00:00:00.000Z","url":"https://doi.org/10.3201/eid3209.260463","source_score":67,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-07T06:30:49.055Z","updated_at":"2026-09-07T06:30:49.055Z","tags":[{"paper_doi":"10.3201/eid3209.260463","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"category","value":"Infectious Diseases","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"condition","value":"Trichophyton indotineae Infection","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"generic","value":"itraconazole","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"generic","value":"terbinafine","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"modality","value":"MALDI-TOF Mass Spectrometry","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"sample_size","value":"n=3399","value_numeric":3399},{"paper_doi":"10.3201/eid3209.260463","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"study_design","value":"Retrospective Surveillance Study","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"warning","value":"Geographic distribution is heavily skewed toward Europe (89.4% of detections) due to MSI user distribution, not necessarily true disease burden.","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"warning","value":"No antifungal susceptibility data were included in this dataset; terbinafine resistance rates cannot be calculated from these findings alone.","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"warning","value":"The 3,399 spectra represent MSI application submissions, not confirmed individual patient cases — true case counts may differ substantially.","value_numeric":null},{"paper_doi":"10.3201/eid3209.260463","tag_type":"warning","value":"The taxonomic status of T. indotineae remains debated (distinct species vs. variety of T. mentagrophytes); alternative names are in use across the literature.","value_numeric":null}],"summaries":{"what_studied":"This study analyzed Mass Spectrometry Identification (MSI) network data from March 2022 to December 2025 to track the global spatial and temporal spread of *Trichophyton indotineae*, a terbinafine-resistant emerging dermatophyte, across 566 users in 54 countries.","key_result":"A ~3-fold increase in *T. indotineae* identifications was observed: from 237 spectra in 2022 to 1,692 in 2025. Its share within the *T. mentagrophytes* complex rose from 4.6% to 13.1%, and the proportion of centers detecting it grew from 24.7% to 46.1%. Europe accounted for 89.4% of detections (3,040/3,399 spectra); new detections were reported in previously unreported countries including Bulgaria, Croatia, Colombia, Luxembourg, and Uruguay.","limitations":"- Geographic coverage reflects MSI device availability and user base, leaving major endemic regions (India, Middle East, Africa) unrepresented.\n- Analysis counts spectra, not individual isolates, making true case burden hard to infer.\n- MSI may be used for research rather than solely for diagnostics, and isolates may be shipped across borders before identification, distorting origin data.","practice_takeaway":"Clinicians should consider *T. indotineae* in patients with treatment-refractory tinea, even without travel history to endemic regions, as local transmission is now documented in Europe. Microbiology labs are encouraged to adopt MALDI-TOF MSI to enable rapid, accurate identification and support real-time surveillance."}},{"doi":"10.1111/myc.70199","pmid":"42307435","title":"Comparison of\n DermaGenius\n and In‐House\n qPCR\n Methods for Detection of Recalcitrant Dermatophyte Infections: A Practical Approach for Dermatologists and Mycologists","journal_title":"Mycoses","journal_issn":"0933-7407","published_at":"2026-06-17T00:00:00.000Z","url":"https://doi.org/10.1111/myc.70199","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-27T13:27:50.648Z","updated_at":"2026-06-27T13:27:50.648Z","tags":[{"paper_doi":"10.1111/myc.70199","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"brand","value":"DermaGenius Resistance Multiplex PCR","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"condition","value":"Recalcitrant Dermatophytosis","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"condition","value":"Terbinafine-Resistant Trichophyton Infection","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"generic","value":"terbinafine","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"modality","value":"Antifungal Susceptibility Testing","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"modality","value":"Multiplex qPCR Diagnostics","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"sample_size","value":"n=64","value_numeric":64},{"paper_doi":"10.1111/myc.70199","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"study_design","value":"Diagnostic Accuracy Study","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"warning","value":"High prevalence of T. indotineae in this cohort (84% of isolates) may inflate apparent concordance and affect kappa interpretation — authors acknowledge this limitation.","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"warning","value":"Level of evidence assigned as 3 (diagnostic cohort study); no randomisation or prospective blinded design was used.","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"warning","value":"One author (E.F.J.M.) has received research funding from PathoNostics, the manufacturer of the DermaGenius RMP kit evaluated in this study; potential conflict of interest should be noted.","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"warning","value":"Study used cultured isolates rather than direct clinical specimens, so performance metrics may not fully reflect direct-from-sample diagnostic accuracy.","value_numeric":null},{"paper_doi":"10.1111/myc.70199","tag_type":"warning","value":"The W450T SQLE substitution is reported as novel in this study; its clinical significance and effect on terbinafine MICs remain unknown and require validation.","value_numeric":null}],"summaries":{"what_studied":"This study compared two qPCR methods — a commercial multiplex assay (DermaGenius RMP) and an in-house *T. indotineae*-specific qPCR (Tindo-qPCR) — for species identification and detection of terbinafine resistance-associated SQLE mutations in 64 dermatophyte isolates from patients with chronic or treatment-resistant dermatophytosis in Türkiye (April–December 2024), validated against ITS/SQLE sequencing and CLSI antifungal susceptibility testing.","key_result":"Overall concordance between the two qPCR methods was 93.8% (κ = 0.74, p < 0.001) for *T. indotineae* identification. SQLE mutations were detected in >90% of *T. indotineae* isolates; F397L was the dominant substitution (89.8%). A novel W450T SQLE substitution was identified. Notably, 10 isolates carried SQLE F397L yet remained terbinafine-susceptible (MIC ≤ 0.016 µg/mL), suggesting genomic background may modulate phenotypic resistance.","limitations":"- Single-centre cohort from Türkiye with a high *T. indotineae* prevalence, limiting geographic generalisability.\n- DermaGenius RMP was tested on cultured isolates, not direct clinical samples, so real-world turnaround benefits were not assessed.\n- Functional significance of SQLE mutations outside positions 393 and 397 (e.g., W450T) remains unvalidated experimentally.","practice_takeaway":"Don't wait for repeated treatment failure — request qPCR-based molecular testing (e.g., DermaGenius RMP) early in patients with chronic or recalcitrant tinea to detect *T. indotineae* and terbinafine resistance mutations before clinical relapse. When molecular and phenotypic susceptibility results diverge, add CLSI antifungal susceptibility testing to guide therapy, since SQLE mutations alone do not always predict elevated terbinafine MICs."}},{"doi":"10.1111/myc.70196","pmid":"42257528","title":"Efficacy Evaluation of Luliconazole‐Loaded Nanostructured Lipid Carriers in Treatment‐Resistant Dermatophytosis: A Randomized Clinical Trial","journal_title":"Mycoses","journal_issn":"0933-7407","published_at":"2026-06-08T00:00:00.000Z","url":"https://doi.org/10.1111/myc.70196","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-12T13:24:33.573Z","updated_at":"2026-06-12T13:24:33.573Z","tags":[{"paper_doi":"10.1111/myc.70196","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"condition","value":"Antifungal-Resistant Fungal Infection","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"condition","value":"Trichophyton indotineae Infection","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"generic","value":"itraconazole","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"generic","value":"luliconazole","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"generic","value":"terbinafine","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"modality","value":"Azole Antifungal","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"modality","value":"Nanostructured Lipid Carrier","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"sample_size","value":"n=48","value_numeric":48},{"paper_doi":"10.1111/myc.70196","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"warning","value":"ITZ monotherapy showed 0% recovery, which may partly reflect subtherapeutic drug levels (no therapeutic drug monitoring performed) rather than resistance alone.","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"warning","value":"Level of evidence assigned as 2 (RCT); however, the open-label, single-center, small-sample design substantially limits confidence compared to a full-scale phase III trial.","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"warning","value":"Open-label design with no placebo control; blinding was not feasible due to different routes of administration (oral vs. topical), which may introduce performance and detection bias.","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"warning","value":"The 'practice_changing' impact flag is applied cautiously — findings are promising but require confirmation in larger, multi-center trials before adoption as standard care.","value_numeric":null},{"paper_doi":"10.1111/myc.70196","tag_type":"warning","value":"Very small per-group sample size (n=12) makes this an exploratory pilot; authors acknowledge it is underpowered to detect smaller between-group differences.","value_numeric":null}],"summaries":{"what_studied":"This open-label randomized clinical trial (n=48 adults, 4 weeks) compared four treatments for confirmed terbinafine-resistant *T. indotineae* dermatophytosis: oral itraconazole (ITZ) alone, topical luliconazole (LCZ) gel, nanostructured lipid carrier–loaded luliconazole (NLC-LCZ) gel, or ITZ + NLC-LCZ gel (n=12 per group).","key_result":"Complete recovery (clinical + mycological cure) rates were: ITZ + NLC-LCZ 83.3%, NLC-LCZ 75%, LCZ 58.3%, and ITZ alone 0% (p<0.01). NLC-LCZ and LCZ had MIC90 of 0.016 μg/mL vs. ITZ MIC90 8 μg/mL and TRB MIC90 4 μg/mL. DLQI scores at 4 weeks: NLC-LCZ 2, ITZ+NLC-LCZ 3, LCZ 5, ITZ 10 (p<0.001). Adverse events were mild (overall 18.8%) and required no discontinuation.","limitations":"- Small single-center pilot (n=12/group); risk of type II error for smaller between-group differences.\n- Short 4-week follow-up with no relapse data, a notable gap given high *T. indotineae* recurrence rates.\n- Open-label design and no pharmacokinetic assessment (skin penetration, drug retention) to confirm proposed NLC delivery mechanisms.","practice_takeaway":"For terbinafine-resistant *T. indotineae* dermatophytosis, topical NLC-LCZ gel—alone or combined with oral itraconazole—achieved far higher cure rates than itraconazole monotherapy, which failed entirely. Clinicians managing refractory cases may consider this combination approach pending larger confirmatory trials."}},{"doi":"10.1111/ijd.70514","pmid":"42231668","title":"Evolution of Dermatophytic Fungi: Anthropogenic and Biogenic Environmental Factors","journal_title":"International Journal of Dermatology","journal_issn":"0011-9059","published_at":"2026-06-02T00:00:00.000Z","url":"https://doi.org/10.1111/ijd.70514","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-10T14:24:13.520Z","updated_at":"2026-06-10T14:24:13.520Z","tags":[{"paper_doi":"10.1111/ijd.70514","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"condition","value":"Antifungal Resistance","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"modality","value":"Antifungal Agent","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"warning","value":"No sample size, age group, or sex data are reported or applicable given the review nature of the paper.","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"warning","value":"Only the abstract was available; no empirical data, patient population, or specific findings could be extracted — all summary content is derived solely from the abstract.","value_numeric":null},{"paper_doi":"10.1111/ijd.70514","tag_type":"warning","value":"Study design classified as 'Narrative Review' based on abstract language, but full article type is not explicitly confirmed.","value_numeric":null}],"summaries":{"what_studied":"This paper examines how anthropogenic factors (e.g., pollution selecting for extremotolerant and antifungal-resistant fungi) and biogenic factors (e.g., zoonotic outbreaks) are shaping the evolution of dermatophytic fungi in the context of climate change.","key_result":"No primary quantitative outcome is reported; the paper provides a conceptual/narrative analysis of environmental drivers — both human-made and biological — that influence dermatophyte evolution and resistance.","limitations":"Abstract-only content available; no sample size, study population, or empirical data are reported, limiting assessment of specific findings or clinical evidence strength.","practice_takeaway":"Clinicians should be alert to emerging antifungal resistance in dermatophytes potentially driven by pollution and climate pressures. Zoonotic dermatophyte outbreaks may increase — heightened surveillance and patient exposure history (including animal contact) are warranted."}},{"doi":"10.1111/ajd.70144","pmid":"42175557","title":"Trichophyton mentagrophytes\n Genotype\n VII\n : Sexually Transmitted Infection Beyond\n MSM","journal_title":"Australasian Journal of Dermatology","journal_issn":"0004-8380","published_at":"2026-05-22T00:00:00.000Z","url":"https://doi.org/10.1111/ajd.70144","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-03T13:44:35.871Z","updated_at":"2026-06-03T13:44:35.871Z","tags":[{"paper_doi":"10.1111/ajd.70144","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"condition","value":"Sexually Transmitted Infection","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"condition","value":"Trichophyton mentagrophytes Genotype VII Infection","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"generic","value":"terbinafine","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"modality","value":"Antifungal Therapy","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"warning","value":"Only the paper title, DOI, journal, and publication date were provided — no full text or abstract. All summary content is inferred from the title alone. Key details such as study design, sample size, specific outcomes, and drug names are not confirmed.","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"warning","value":"Study design, level of evidence, sex of participants, and sample size tags could not be determined from available metadata.","value_numeric":null},{"paper_doi":"10.1111/ajd.70144","tag_type":"warning","value":"The 'practice_takeaway' regarding antifungal therapy and the 'generic' tag for terbinafine are speculative, as no drug data were present in the provided text; these reflect common clinical context for TMVII and may not reflect the paper's actual content.","value_numeric":null}],"summaries":{"what_studied":"This paper evaluates *Trichophyton mentagrophytes* genotype VII (TMVII) as a sexually transmitted infection (STI), examining whether transmission extends beyond men who have sex with men (MSM) to other populations.","key_result":"The study reports that TMVII transmission is not limited to MSM, suggesting broader sexual transmission pathways across other population groups.","limitations":"The full text is not available for detailed extraction; specific sample sizes, comparators, and outcome numbers cannot be confirmed from the provided metadata alone.","practice_takeaway":"Clinicians should consider TMVII dermatophytosis as a potential STI in any sexually active patient presenting with refractory or atypical tinea, not only in MSM. Sexual history and contact tracing may be warranted."}},{"doi":"10.1016/j.ijmmb.2026.101128","pmid":"42069084","title":"Indian Fungal Infection National Declaration (I-Find)","journal_title":"Indian Journal of Medical Microbiology","journal_issn":"0255-0857","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.ijmmb.2026.101128","source_score":22,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-21T13:20:58.302Z","updated_at":"2026-05-21T13:20:58.302Z","tags":[{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"category","value":"Immunology","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Aspergillosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Candidiasis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Fungal Keratitis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Invasive Fungal Disease","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Mucormycosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Vulvovaginal Candidiasis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"generic","value":"azole antifungals","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"modality","value":"Antifungal Stewardship","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"study_design","value":"Consensus Statement / Policy Declaration","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"Study design label 'Consensus Statement / Policy Declaration' is not a standard RCT/cohort design; clinicians should interpret recommendations as expert-level guidance pending formal empirical validation.","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"The 4.1% population burden estimate and ~50% invasive fungal disease mortality figures are cited from prior literature; the declaration does not independently validate these numbers.","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"This paper is a policy/consensus declaration, not an interventional or observational study — no primary data are presented. Level of evidence is set at 7 (expert opinion/consensus).","value_numeric":null}],"summaries":{"what_studied":"The Indian Fungal Infection National Declaration (I-FIND) evaluates the burden of serious fungal diseases in India — estimated to affect 4.1% of the population — and proposes a structured, time-bound national response across 9 core domains to reduce morbidity, mortality, and antifungal resistance.","key_result":"Mortality from invasive fungal diseases in India approaches 50%, surpassing several nationally prioritised conditions; key pathogens of concern include *Candidozyma auris*, azole-resistant *Aspergillus fumigatus*, and *Trichophyton indotineae*, with COVID-19-associated mucormycosis highlighting critical preparedness gaps.","limitations":"This is a consensus declaration rather than an original research study, so it does not present new primary data; burden estimates are derived from prior literature and may not capture current real-world epidemiology across all Indian regions.","practice_takeaway":"Clinicians should recognise fungal diseases — especially in immunocompromised, critically ill, chronic lung disease, and poorly controlled diabetic patients — as a major, under-prioritised public health threat in India. Proactive antifungal stewardship and early diagnostics are key actions supported by this declaration."}},{"doi":"10.1001/jamadermatol.2024.1126","pmid":"38748419","title":"Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of Trichophyton indotineae","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2024-05-15T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2024.1126","source_score":127,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2024-06-06","doi":"10.1001/jamadermatol.2024.1126","days":"30","issn":"2168-6068","rank":"5","field":"Clinical Medicine","score":"127","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1001/jamadermatol.2024.1126","title":"Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of Trichophyton indotineae.","journal":"JAMA dermatology","methods":"","results":"$30","abstract":"$31","keywords":[],"pubmed_id":"38748419","conclusions":"","publication_date":"2024-05-15T00:00:00"},"crossref":{"DOI":"10.1001/jamadermatol.2024.1126","URL":"https://doi.org/10.1001/jamadermatol.2024.1126","ISSN":["2168-6068"],"link":[{"URL":"https://jamanetwork.com/journals/jamadermatology/articlepdf/2818522/jamadermatology_caplan_2024_oi_240012_1721149713.16585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"701","type":"journal-article","issue":"7","score":1,"title":["Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of Trichophyton indotineae"],"author":[{"given":"Avrom S.","family":"Caplan","sequence":"first","affiliation":[{"name":"The Ronald O. 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Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York"},{"name":"Dermatology Service, Bellevue Hospital Center, New York, New York"}]},{"given":"Jeannette","family":"Jakus","sequence":"additional","affiliation":[{"name":"SUNY Downstate Health Sciences University, Department of Dermatology, Brooklyn, New York"}]},{"given":"Shari R.","family":"Lipner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine, New York, New York"}]},{"given":"Kayla Babbush","family":"Graber","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medicine, New York, New York"}]},{"given":"Karen P.","family":"Acker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Weill Cornell Medicine, New York, New York"}]},{"given":"Ayana E.","family":"Morales","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York"}]},{"given":"Rebecca M. 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W.","family":"Gold","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia"}]},{"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia"}]},{"given":"Dallas J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia"}]},{"given":"Tom","family":"Chiller","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia"}]},{"given":"William G.","family":"Greendyke","sequence":"additional","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, New York, New York"}]},{"given":"Swati R.","family":"Manjari","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Wadsworth Center, New 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based on last follow‑up, and two patients on itraconazole were lost to follow‑up or stopped treatment.","value_numeric":null}],"summaries":{"what_studied":"A retrospective cohort case series from six New York City centers (May 2022–May 2023) examined 11 patients with confirmed Trichophyton indotineae, correlating clinical features with antifungal minimum inhibitory concentrations, squalene epoxidase mutations, and whole‑genome sequencing; outcome was improvement or resolution at last follow‑up.","key_result":"Terbinafine (250 mg daily) failed in 7 patients, and their isolates carried SQLE L393S or F397L with elevated terbinafine MICs ≥0.5 μg/mL. Improvement occurred in 2/4 on fluconazole and 2/5 on griseofulvin (no outcome–MIC correlation); 5/7 on itraconazole cleared or improved (2/7 lost to follow‑up or stopped), and U.S. isolates formed a distinct cluster from Indian isolates; 9/11 reported travel to Bangladesh.","limitations":"Small sample (n=11) and single‑city, multi‑center case series limit generalizability. Uncontrolled, retrospective design with heterogeneous treatments and incomplete follow‑up (2 of 7 on itraconazole lost or stopped) constrains outcome interpretation.","practice_takeaway":"Expect terbinafine failure associated with SQLE mutations and elevated MICs in T indotineae; in this series, itraconazole led to clearance or improvement in 5 of 7 treated patients. Take a travel history—most patients reported travel to Bangladesh—and consider susceptibility testing when terbinafine fails."}}],"initialOffset":8,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Dermatophytosis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Dermatophytosis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Dermatophytosis"}}}]]

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