2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T727,Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.31:T97b, Objective: Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. Method: A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. Results: The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as ‘other’ (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Conclusion: Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds. 32:T6c7,AbstractElevated levels of bacteria, including biofilm, increase the risk of chronic wound infection and inhibit healing. Addressing asymptomatic high bacterial loads is challenged by a lack of clinical terminology and diagnostic tools. This post‐hoc multicenter clinical trial analysis of 138 diabetic foot ulcers investigates fluorescence (FL)‐imaging role in detecting biofilm‐encased and planktonic bacteria in wounds at high loads. The sensitivity and specificity of clinical assessment and FL‐imaging were compared across bacterial loads of concern (104–109 CFU/g). Quantitative tissue culture confirmed the total loads. Bacterial presence was confirmed in 131/138 ulcers. Of these, 93.9% had loads >104 CFU/g. In those wounds, symptoms of infection were largely absent and did not correlate with, or increase proportionately with, bacterial loads at any threshold. FL‐imaging increased sensitivity for the detection of bacteria across loads 104–109 (P < .0001), peaking at 92.6% for >108 CFU/g. Imaging further showed that 84.2% of ulcers contained high loads in the periwound region. New terminology, chronic inhibitory bacterial load (CIBL), describes frequently asymptomatic, high bacterial loads in diabetic ulcers and periwound tissues, which require clinical intervention to prevent sequelae of infection. We anticipate this will spark a paradigm shift in assessment and management, enabling earlier intervention along the bacterial‐infection continuum and supporting improved wound outcomes.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Diabetic Foot Ulcer: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Diabetic Foot Ulcer (condition). Clinician-written summaries and actionable practice insights. 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Searches covered MEDLINE, CINAHL, Embase, Scopus, and grey literature; 11 studies (published 2015 onward) met inclusion criteria.","key_result":"Validation studies showed good-to-excellent agreement between AI and manual wound measurements (ICC 0.799–0.995). AI measurement was 77% faster than manual methods and cut overall assessment time by 79%. Estimated health system savings ranged from AUD $1.7–3.3M/year (Australia) to ~US $958,201/year (Canada). Evidence on long-term sustainability and EHR interoperability was sparse.","limitations":"- Only 11 studies included, most from high-income countries, limiting generalisability.\n- Evidence concentrated around a small number of commercial platforms (e.g., Tissue Analytics, Swift Skin and Wound), with frequent industry ties among study authors.\n- Most evaluations were short-term, single-arm, or pre-post designs without confounding adjustment, weakening sustainability conclusions.","practice_takeaway":"AI wound tools can reliably measure wounds and reduce documentation burden across outpatient, community, and home settings — treat them as decision-support aids that augment, not replace, clinical judgement. Successful adoption will likely hinge on EHR interoperability and organisational investment in training, not just technical accuracy."}},{"doi":"10.1097/asw.0000000000000506","pmid":"42585462","title":"Advancing Chronic Wound Healing: Innovations in Hooked Array Nylon Fabric for Wound Hygiene, Debridement, and Tissue Sampling","journal_title":"Advances in Skin & Wound Care","journal_issn":"1527-7941","published_at":"2026-08-12T00:00:00.000Z","url":"https://doi.org/10.1097/asw.0000000000000506","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-10T06:20:07.366Z","updated_at":"2026-09-10T06:20:07.366Z","tags":[{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"brand","value":"Kylon","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"condition","value":"Chronic Wounds","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"condition","value":"Pressure Injury","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"condition","value":"Wound Biofilm","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"modality","value":"Mechanical Debridement Device","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"modality","value":"Wound Biopsy","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"study_design","value":"Practice Reflection / Narrative Review","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"warning","value":"No sample size tag applied: the paper does not report a unified study population — it aggregates anecdotal cases and cited literature.","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"warning","value":"One co-author is founder and CEO of Histologics LLC, the manufacturer of the device reviewed; despite stated independence, commercial bias cannot be fully excluded.","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"warning","value":"Study design classification as 'Narrative Review' is approximate; the paper blends review, expert opinion, and case examples without a systematic literature search methodology.","value_numeric":null},{"paper_doi":"10.1097/asw.0000000000000506","tag_type":"warning","value":"The article is classified as a 'Practice Reflection,' not a primary research study; the majority of clinical evidence cited comes from conference abstracts and case reports rather than peer-reviewed controlled trials.","value_numeric":null}],"summaries":{"what_studied":"This practice reflection reviews the clinical evolution, applications, and future potential of a hooked array nylon fabric device (Kylon, Histologics LLC) — originally designed for cervical biopsy — as a tool for wound hygiene, mechanical/surgical debridement, biofilm disruption, and tissue sampling in chronic wounds affecting ~6.5 million Americans annually.","key_result":"Across case reports and conference presentations, the device enabled atraumatic debridement, tangential wound biopsy, and biofilm disruption at three tiered levels (wound hygiene, mechanical, and surgical/excisional) without sharps; one case report showed a 96-year-old with Stage 4 pressure injury over the Achilles healed over 30 weeks under local anesthesia, avoiding OR and skin grafting.","limitations":"- Evidence base consists primarily of case reports, conference abstracts, and one RCT in a gynecological (not wound care) setting; no wound-specific RCTs are available.\n- One co-author (Neal Lonky) is founder/CEO of Histologics LLC, the manufacturer, introducing potential conflict of interest despite stated independence.\n- No comparative data on healing rates, recurrence, or cost-effectiveness versus standard debridement methods in wound care populations.","practice_takeaway":"Hooked nylon fabric may offer a low-trauma, no-sharps-required option for wound debridement and tangential biopsy across skill levels and settings — including home care and low-resource environments — but clinicians should recognize that robust wound-specific trial data are lacking and current evidence is largely expert opinion and case-level."}},{"doi":"10.1016/j.diabres.2026.113453","pmid":"42480715","title":"The effect of foot positioning on tissue oxygenation in diabetic foot ulcers","journal_title":"Diabetes Research and Clinical Practice","journal_issn":"0168-8227","published_at":"2026-07-21T00:00:00.000Z","url":"https://doi.org/10.1016/j.diabres.2026.113453","source_score":8,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-31T13:36:55.986Z","updated_at":"2026-07-31T13:36:55.986Z","tags":[{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"category","value":"Endocrinology & Metabolism","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"modality","value":"Positional Therapy","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"sample_size","value":"n=60","value_numeric":60},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"warning","value":"Convenience sampling is used despite randomization, which may introduce selection bias not fully captured in the study design label.","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"warning","value":"Sex of participants is not reported in the abstract; the sex tag was omitted.","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"warning","value":"The paper's DOI and publication date (2026) are noted; this is a recently published study and has not yet been widely cited or replicated.","value_numeric":null},{"paper_doi":"10.1016/j.diabres.2026.113453","tag_type":"warning","value":"The 'practice_changing' impact flag is applied cautiously — the finding is clinically compelling but the small sample and short duration warrant replication before wide adoption.","value_numeric":null}],"summaries":{"what_studied":"A randomized clinical trial (Feb–Jul 2025, n=60 hospitalized adults) compared 15° foot elevation for 24 hours vs. supine positioning (control) on tissue oxygenation in diabetic foot ulcers, measuring TcPO2, ABI, TBI, and toe pressure.","key_result":"15° foot elevation improved all four outcomes vs. supine: TcPO2 +5.26 vs. −5.6 mmHg (p=0.027), ABI +0.14 vs. −0.11 (p=0.002), TBI +0.17 vs. −0.14 (p=0.008), and toe pressure +18.5 vs. −15 mmHg (p=0.005).","limitations":"Small sample (n=60) recruited by convenience sampling limits generalizability; single-center inpatient setting may not reflect outpatient or home care populations; 24-hour timeframe leaves longer-term effects unknown.","practice_takeaway":"Consider 15° foot elevation as a simple, no-cost adjunct for hospitalized patients with diabetic foot ulcers to improve perfusion. This maneuver may also be taught to patients for home care use."}},{"doi":"10.12968/jowc.2026.0290","pmid":null,"title":"Early reported effects of the 2026 CMS Physician Fee Schedule on patient access to CAMPs in wound care: a national clinician and practice survey","journal_title":"Journal of Wound Care","journal_issn":"0969-0700","published_at":"2026-06-12T00:00:00.000Z","url":"https://doi.org/10.12968/jowc.2026.0290","source_score":22,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-06-18T13:24:31.809Z","updated_at":"2026-06-18T13:24:31.809Z","tags":[{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"condition","value":"Chronic Wounds","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"modality","value":"Cellular, Acellular and Matrix-Like Products (CAMPs)","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"modality","value":"Skin Substitutes","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"sample_size","value":"n=130","value_numeric":130},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"study_design","value":"Cross-Sectional Survey","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"warning","value":"Low response rate (~3%) and self-selection bias substantially limit generalizability; findings reflect perceived rather than objectively measured impacts.","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"warning","value":"Specific wound types or patient populations (e.g., diabetic foot ulcer, venous leg ulcer) are not disaggregated in the reported results.","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"warning","value":"Study design is classified as cross-sectional survey; no comparator group or pre/post outcome data are provided.","value_numeric":null},{"paper_doi":"10.12968/jowc.2026.0290","tag_type":"warning","value":"The survey was conducted only 69 days after policy implementation, so long-term effects remain unknown.","value_numeric":null}],"summaries":{"key_result":"96% of 130 respondents reported at least one operational impact; 45% reported closure or planned closure of a wound care practice or service line; 61% cited authorization delays for clinically eligible patients. Only 5 respondents (4%) reported no significant impact.","limitations":"Very low response rate (~3% of 4,551 eligible NPIs); self-selected sample introduces response bias; survey relied on perceived/reported impacts rather than objective outcome data.","what_studied":"A national online survey assessed the perceived impact of the 2026 CMS Physician Fee Schedule update, which set a unified reimbursement rate of $127.14/cm² for all skin substitutes (CAMPs), on wound care practitioners and practices across the US (February–April 2026).","practice_takeaway":"Wound care clinicians—especially those in non-facility settings—should be aware that the 2026 uniform CAMP payment policy is already driving service closures and access barriers, with reported patient harms including infection, amputation, and hospital readmission. Advocacy for reimbursement policy reevaluation and proactive care-setting planning are warranted."}},{"doi":"10.1016/j.euroneuro.2026.112880","pmid":"42217371","title":"Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records","journal_title":"European Neuropsychopharmacology","journal_issn":"0924-977X","published_at":"2026-05-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.euroneuro.2026.112880","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-07T13:26:34.220Z","updated_at":"2026-06-07T13:26:34.220Z","tags":[{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"category","value":"Clinical Neurology","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Anxiety Disorders","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Attention-Deficit/Hyperactivity Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Autism Spectrum Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Dementia","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Major Depressive Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Metabolic Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Mild Cognitive Impairment","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Polycystic Ovary Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Schizophrenia","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Type 1 Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Type 2 Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Vitamin D Deficiency","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"sample_size","value":"n=254154533","value_numeric":254154533},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"study_design","value":"Umbrella Review","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"Full publisher text was inaccessible due to a CAPTCHA block; all structured data are derived exclusively from the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"Sample size reflects the total number of records across all included meta-analyses, not unique individuals, so overlap between studies is likely.","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"The umbrella review pools observational meta-analyses only — causal direction between psychiatric and metabolic conditions cannot be established.","value_numeric":null}],"summaries":{"what_studied":"An umbrella review of 81 meta-analyses (254,154,533 records; 1,780 individual studies) examined the prevalence and clinical outcomes of co-occurring psychiatric disorders and endocrine, nutritional, or metabolic conditions, using DSM/ICD diagnostic criteria and AMSTAR-2 quality grading.","key_result":"10 of 64 prevalence estimates reached strong credibility, including MDD in diabetes mellitus (61.8%), vitamin D deficiency in schizophrenia (65.3%), anxiety in PCOS (48%), and mild cognitive impairment in type-2 diabetes (45%). Among outcomes with strong credibility: comorbid MDD roughly doubled dementia risk (RR=2.1) and raised all-cause mortality by 48% (RR=1.48) in diabetic patients; ADHD comorbidity raised HbA1c by ~0.6–0.7 SD in children with type-1 diabetes and women with type-2 diabetes.","limitations":"Only observational meta-analyses were included, limiting causal inference. Most estimates came from cross-sectional or heterogeneous studies, and many prevalence and outcome estimates did not meet strong credibility criteria (only 6.4% and 11.7%, respectively). Publisher full text was inaccessible; summary is based on the abstract alone.","practice_takeaway":"Clinicians managing diabetes, PCOS, or metabolic syndrome should routinely screen for depression and anxiety, given high co-prevalence and the finding that comorbid MDD nearly doubles dementia risk and raises mortality by 48% in diabetic patients. Children with type-1 diabetes and comorbid ADHD warrant closer glycemic monitoring, as HbA1c levels are meaningfully higher in this group."}},{"doi":"10.12968/jowc.2025.0459","pmid":"41205152","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies","journal_title":"Journal of Wound Care","journal_issn":"0969-0700","published_at":"2025-11-08T00:00:00.000Z","url":"https://doi.org/10.12968/jowc.2025.0459","source_score":38,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-30","doi":"10.12968/jowc.2025.0459","days":"7","issn":"0969-0700","rank":"2","field":"Clinical Medicine","score":"38","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.12968/jowc.2025.0459","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies.","journal":"Journal of wound care","methods":"A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters.","results":"The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product.","abstract":"$30","keywords":["CompleteFT","amniotic membrane","chronic wounds","complex wounds","full-thickness membrane","hard-to-heal","placental allograft","wound","wound care","wound closure","wound covering","wound dressing"],"pubmed_id":"41205152","conclusions":"Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.","publication_date":"2025-11-08T00:00:00"},"crossref":{"DOI":"10.12968/jowc.2025.0459","URL":"https://doi.org/10.12968/jowc.2025.0459","ISSN":["0969-0700","2052-2916"],"link":[{"URL":"http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2025.0459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"S15-S24","type":"journal-article","issue":"S11a","score":1,"title":["Application of a full-thickness 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Care"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.12968/jowc.2025.0459","is_oa":false,"title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies","updated":"2025-10-27T16:35:26+00:00","published_date":"2025-10-22","best_oa_location":null}},"created_at":"2025-12-02T07:03:10.886Z","updated_at":"2025-12-08T12:24:58.509Z","tags":[{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"brand","value":"CompleteFT","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Pressure 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Outcomes included trends in wound surface area and percentage area reduction (PAR) by wound etiology.","key_result":"Among 114 patients with 184 wounds (mean age 73.1; 51 male, 63 female), PAR was statistically significant for diabetic foot ulcers (n=11), venous leg ulcers (n=48), pressure ulcers (n=73), and ‘other’ wounds (n=39) with p<0.0001, and for surgical wounds (n=13) with p<0.0007; no adverse events were directly attributed to the product.","limitations":"Retrospective, single-provider case series without a control group and with heterogeneous wound types. The abstract reports p-values but not PAR magnitudes or time-to-closure.","practice_takeaway":"Adjunct use of a full-thickness placental allograft was associated with wound size regression across several chronic wound etiologies and appeared well tolerated, but the uncontrolled design and absent effect sizes limit clinical inference."}},{"doi":"10.1111/iwj.14080","pmid":"36708275","title":"Point‐of‐care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers","journal_title":"International Wound Journal","journal_issn":"1742-4801","published_at":"2023-01-29T00:00:00.000Z","url":"https://doi.org/10.1111/iwj.14080","source_score":391,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2023-02-15","doi":"10.1111/iwj.14080","days":"30","issn":"1742-4801","rank":"2","field":"Clinical Medicine","score":"391","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/iwj.14080","title":"Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers.","journal":"International wound journal","methods":"","results":"","abstract":"Elevated levels of bacteria, including biofilm, increase the risk of chronic wound infection and inhibit healing. 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