2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4f5,During up to 32 years of follow-up of 231 067 men and women (median age, 43 [IQR, 36-55] years), a total of 6538 incident DSCs and 3791 DSC deaths were documented. Higher physical activity levels were associated with lower DSC risk (≥45 vs <3 MET-hours/week; hazard ratio [HR], 0.83; 95% CI, 0.74-0.93; P < .001 for trend) and mortality (HR, 0.72; 95% CI, 0.62-0.83; P < .001 for trend). The inverse associations were evident for both digestive tract and accessory organ cancers: the HRs comparing greater than or equal to 45 vs 3 MET-hours/week were 0.85 (95% CI, 0.75-0.97) for digestive tract cancer risk and 0.73 (95% CI, 0.58-0.92) for digestive accessory organ cancer risk. The traditional dose-response analysis suggested the lowest DSC risk was achieved at approximately 50 MET-hours/week. However, when long-term consistency was considered, compared with those with minimal activity, consistently reaching the guideline at moderate levels (median, 16.9 [IQR, 13.6-20.5] MET-hours/week) over 3 decades was associated with substantial reductions in DSC risk (HR, 0.83; 95% CI, 0.75-0.90), whereas that performing much higher amounts (median, 38.5 [IQR, 28.5-53.8] MET-hours/week) was not associated with further benefit (HR, 0.87; 95% CI, 0.81-0.93).31:Tb73,Growing evidence suggests that physical activity protects against digestive system cancers (DSCs). However, it remains largely unknown whether consistently reaching the physical activity guidelines (≥7.5 metabolic equivalent task [MET]-hours/week) is associated with lower DSC risk or whether a much higher level is needed. To examine the association between physical activity and DSC risk and mortality with a focus on the optimal amount and long-term consistency in performing the recommended level over a long period of time. This population-based cohort study includes data from 3 large US prospective cohorts: Health Professionals Follow-Up Study, 1988-2020; Nurses' Health Study, 1988-2021; and Nurses' Health Study II, 1991-2021. Data analysis was performed between October 2024 and May 2025. Participants were men and women free from cancer and cardiovascular disease at baseline. Total levels of leisure-time physical activity were assessed with biennial validated questionnaires and expressed in MET-hours per week. Consistency was calculated as the percentage of follow-up years meeting the recommended level (≥7.5 MET-hours/week). DSCs included cancers of digestive tract (mouth, throat, esophagus, stomach, small intestine, colon, and rectum) and digestive accessory organs (pancreas, gallbladder, and liver). During up to 32 years of follow-up of 231 067 men and women (median age, 43 [IQR, 36-55] years), a total of 6538 incident DSCs and 3791 DSC deaths were documented. Higher physical activity levels were associated with lower DSC risk (≥45 vs <3 MET-hours/week; hazard ratio [HR], 0.83; 95% CI, 0.74-0.93; P < .001 for trend) and mortality (HR, 0.72; 95% CI, 0.62-0.83; P < .001 for trend). The inverse associations were evident for both digestive tract and accessory organ cancers: the HRs comparing greater than or equal to 45 vs 3 MET-hours/week were 0.85 (95% CI, 0.75-0.97) for digestive tract cancer risk and 0.73 (95% CI, 0.58-0.92) for digestive accessory organ cancer risk. The traditional dose-response analysis suggested the lowest DSC risk was achieved at approximately 50 MET-hours/week. However, when long-term consistency was considered, compared with those with minimal activity, consistently reaching the guideline at moderate levels (median, 16.9 [IQR, 13.6-20.5] MET-hours/week) over 3 decades was associated with substantial reductions in DSC risk (HR, 0.83; 95% CI, 0.75-0.90), whereas that performing much higher amounts (median, 38.5 [IQR, 28.5-53.8] MET-hours/week) was not associated with further benefit (HR, 0.87; 95% CI, 0.81-0.93). In this study, traditional dose-response analysis suggested that approximately 50 MET-hours/week was associated with optimal DSC risk reduction. After incorporating long-term consistency, maintenance of a moderate level approximately 17 MET-hours/week over 3 decades was associated with achieving optimal benefit in reducing DSC risk.32:T1143, Importance Growing evidence suggests that physical activity protects against digestive system cancers (DSCs). However, it remains largely unknown whether consistently reaching the physical activity guidelines (≥7.5 metabolic equivalent task [MET]-hours/week) is associated with lower DSC risk or whether a much higher level is needed. Objective To examine the association between physical activity and DSC risk and mortality with a focus on the optimal amount and long-term consistency in performing the recommended level over a long period of time. Design, Setting, and Participants This population-based cohort study includes data from 3 large US prospective cohorts: Health Professionals Follow-Up Study, 1988-2020; Nurses’ Health Study, 1988-2021; and Nurses’ Health Study II, 1991-2021. Data analysis was performed between October 2024 and May 2025. Participants were men and women free from cancer and cardiovascular disease at baseline. Exposures Total levels of leisure-time physical activity were assessed with biennial validated questionnaires and expressed in MET-hours per week. Consistency was calculated as the percentage of follow-up years meeting the recommended level (≥7.5 MET-hours/week). Main Outcomes and Measures DSCs included cancers of digestive tract (mouth, throat, esophagus, stomach, small intestine, colon, and rectum) and digestive accessory organs (pancreas, gallbladder, and liver). Results During up to 32 years of follow-up of 231 067 men and women (median age, 43 [IQR, 36-55] years), a total of 6538 incident DSCs and 3791 DSC deaths were documented. Higher physical activity levels were associated with lower DSC risk (≥45 vs &lt;3 MET-hours/week; hazard ratio [HR], 0.83; 95% CI, 0.74-0.93; P &lt; .001 for trend) and mortality (HR, 0.72; 95% CI, 0.62-0.83; P &lt; .001 for trend). The inverse associations were evident for both digestive tract and accessory organ cancers: the HRs comparing greater than or equal to 45 vs 3 MET-hours/week were 0.85 (95% CI, 0.75-0.97) for digestive tract cancer risk and 0.73 (95% CI, 0.58-0.92) for digestive accessory organ cancer risk. The traditional dose-response analysis suggested the lowest DSC risk was achieved at approximately 50 MET-hours/week. However, when long-term consistency was considered, compared with those with minimal activity, consistently reaching the guideline at moderate levels (median, 16.9 [IQR, 13.6-20.5] MET-hours/week) over 3 decades was associated with substantial reductions in DSC risk (HR, 0.83; 95% CI, 0.75-0.90), whereas that performing much higher amounts (median, 38.5 [IQR, 28.5-53.8] MET-hours/week) was not associated with further benefit (HR, 0.87; 95% CI, 0.81-0.93). Conclusions and Relevance In this study, traditional dose-response analysis suggested that approximately 50 MET-hours/week was associated with optimal DSC risk reduction. After incorporating long-term consistency, maintenance of a moderate level approximately 17 MET-hours/week over 3 decades was associated with achieving optimal benefit in reducing DSC risk. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Digestive System Cancer: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Digestive System Cancer (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Digestive%20System%20Cancer\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Digestive System Cancer\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Digestive%20System%20Cancer\"}]}}"}}]],["$","$L2f",null,{"title":"Digestive System Cancer: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Digestive System Cancer with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1001/jamaoncol.2025.4185","pmid":"41165700","title":"Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality","journal_title":"JAMA Oncology","journal_issn":"2374-2437","published_at":"2025-10-30T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12576613/","source_score":154,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-19","doi":"10.1001/jamaoncol.2025.4185","days":"30","issn":"2374-2437","rank":"10","field":"Clinical Medicine","score":"154","category":"Oncology","categories":["Oncology"],"_categories":["Oncology"]},"pubmed":{"doi":"10.1001/jamaoncol.2025.4185","title":"Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality.","journal":"JAMA oncology","methods":"","results":"$30","abstract":"$31","keywords":[],"pubmed_id":"41165700","conclusions":"","publication_date":"2025-10-30T00:00:00"},"crossref":{"DOI":"10.1001/jamaoncol.2025.4185","URL":"https://doi.org/10.1001/jamaoncol.2025.4185","ISSN":["2374-2437"],"link":[{"URL":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2840507/jamaoncology_zhang_2025_oi_250065_1765564172.9479.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1488","type":"journal-article","issue":"12","score":1,"title":["Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality"],"author":[{"given":"Yiwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}]},{"given":"Dong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Republic of Korea"}]},{"given":"Leandro F. M.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Chronic Disease Epidemiology Research Center, Department of Preventive Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil"},{"name":"Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Chile"}]},{"given":"NaNa","family":"Keum","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Dongguk University, Goyang, Republic of Korea"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}]}],"issued":{"date-parts":[[2025,12,1]]},"member":"10","prefix":"10.1001","source":"Crossref","volume":"11","created":{"date-time":"2025-10-30T15:31:39Z","timestamp":1761838299000,"date-parts":[[2025,10,30]]},"indexed":{"date-time":"2025-12-18T20:08:29Z","timestamp":1766088509500,"date-parts":[[2025,12,18]]},"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"https://jamanetwork.com/journals/jamaoncology/fullarticle/2840507"}},"subtitle":[],"deposited":{"date-time":"2025-12-18T16:00:51Z","timestamp":1766073651000,"date-parts":[[2025,12,18]]},"issn-type":[{"type":"print","value":"2374-2437"}],"published":{"date-parts":[[2025,12,1]]},"publisher":"American Medical Association (AMA)","reference":[{"DOI":"10.3322/caac.21834","key":"coi250065r1","year":"2024","issue":"3","author":"Bray","volume":"74","first-page":"229","unstructured":null,"article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","journal-title":"CA Cancer J Clin","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10620-019-05603-9","key":"coi250065r2","year":"2019","issue":"10","author":"Karczewski","volume":"64","first-page":"2740","unstructured":null,"article-title":"Obesity and the risk of gastrointestinal cancers.","journal-title":"Dig Dis Sci","doi-asserted-by":"publisher"},{"DOI":"10.3892/ijmm.2014.1786","key":"coi250065r3","year":"2014","issue":"2","author":"Li","volume":"34","first-page":"372","unstructured":null,"article-title":"Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).","journal-title":"Int J Mol Med","doi-asserted-by":"publisher"},{"DOI":"10.1080/713609333","key":"coi250065r4","year":"2003","issue":"2","author":"Salaspuro","volume":"40","first-page":"183","unstructured":null,"article-title":"Acetaldehyde, microbes, and cancer of the digestive tract.","journal-title":"Crit Rev Clin Lab Sci","doi-asserted-by":"publisher"},{"DOI":"10.14309/ajg.0000000000002448","key":"coi250065r5","year":"2023","issue":"11","author":"Kim","volume":"118","first-page":"2061","unstructured":null,"article-title":"A Comparative study of healthy dietary patterns for incident and fatal digestive system cancer.","journal-title":"Am J Gastroenterol","doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djs207","key":"coi250065r6","year":"2012","issue":"11","author":"Ballard-Barbash","volume":"104","first-page":"815","unstructured":null,"article-title":"Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review.","journal-title":"J Natl Cancer Inst","doi-asserted-by":"publisher"},{"DOI":"10.1093/jn/132.11.3456S","key":"coi250065r7","year":"2002","issue":"11","author":"Friedenreich","volume":"132","first-page":"3456S","unstructured":null,"article-title":"Physical activity and cancer prevention: etiologic evidence and biological mechanisms.","journal-title":"J Nutr","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jshs.2020.09.009","key":"coi250065r8","year":"2021","issue":"1","author":"Xie","volume":"10","first-page":"4","unstructured":null,"article-title":"Association between physical activity and digestive-system cancer: an updated systematic review and meta-analysis.","journal-title":"J Sport Health Sci","doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.21591","key":"coi250065r9","year":"2020","issue":"4","author":"Rock","volume":"70","first-page":"245","unstructured":null,"article-title":"American Cancer Society guideline for diet and physical activity for cancer prevention.","journal-title":"CA Cancer J Clin","doi-asserted-by":"publisher"},{"DOI":"10.3390/cancers16213594","key":"coi250065r10","year":"2024","issue":"21","author":"Bos","volume":"16","first-page":"3594","unstructured":null,"article-title":"Association between physical activity and pancreatic cancer risk and mortality: a systematic review and meta-analysis.","journal-title":"Cancers (Basel)","doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2016.0740","key":"coi250065r11","year":"2016","issue":"9","author":"Keum","volume":"2","first-page":"1146","unstructured":null,"article-title":"Association of physical activity by type and intensity with digestive system cancer risk.","journal-title":"JAMA Oncol","doi-asserted-by":"publisher"},{"DOI":"10.1093/oxfordjournals.aje.a116211","key":"coi250065r12","year":"1992","issue":"10","author":"Rimm","volume":"135","first-page":"1114","unstructured":null,"article-title":"Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals.","journal-title":"Am J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1093/ije/18.4.858","key":"coi250065r13","year":"1989","issue":"4","author":"Salvini","volume":"18","first-page":"858","unstructured":null,"article-title":"Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption.","journal-title":"Int J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1016/0002-8223(93)91754-E","key":"coi250065r14","year":"1993","issue":"7","author":"Feskanich","volume":"93","first-page":"790","unstructured":null,"article-title":"Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire.","journal-title":"J Am Diet Assoc","doi-asserted-by":"publisher"},{"DOI":"10.1249/00005768-199301000-00011","key":"coi250065r15","year":"1993","issue":"1","author":"Ainsworth","volume":"25","first-page":"71","unstructured":null,"article-title":"Compendium of physical activities: classification of energy costs of human physical activities.","journal-title":"Med Sci Sports Exerc","doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2018.14854","key":"coi250065r16","year":"2018","issue":"19","author":"Piercy","volume":"320","first-page":"2020","unstructured":null,"article-title":"The physical activity guidelines for Americans.","journal-title":"JAMA","doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.20140","key":"coi250065r17","year":"2012","issue":"1","author":"Kushi","volume":"62","first-page":"30","unstructured":null,"article-title":"American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity.","journal-title":"CA Cancer J Clin","doi-asserted-by":"publisher"},{"DOI":"10.1093/ije/23.5.991","key":"coi250065r18","year":"1994","issue":"5","author":"Wolf","volume":"23","first-page":"991","unstructured":null,"article-title":"Reproducibility and validity of a self-administered physical activity questionnaire.","journal-title":"Int J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1097/00001648-199601000-00014","key":"coi250065r19","year":"1996","issue":"1","author":"Chasan-Taber","volume":"7","first-page":"81","unstructured":null,"article-title":"Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals.","journal-title":"Epidemiology","doi-asserted-by":"publisher"},{"DOI":"10.1093/aje/kwab294","key":"coi250065r20","year":"2022","issue":"4","author":"Al-Shaar","volume":"191","first-page":"696","unstructured":null,"article-title":"Reproducibility, validity, and relative validity of self-report methods for assessing physical activity in epidemiologic studies: findings from the Women’s Lifestyle Validation Study.","journal-title":"Am J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1093/aje/kwac051","key":"coi250065r21","year":"2022","issue":"7","author":"Pernar","volume":"191","first-page":"1307","unstructured":null,"article-title":"Validity and relative validity of alternative methods of assessing physical activity in epidemiologic studies: findings from the Men’s Lifestyle Validation Study.","journal-title":"Am J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1093/oxfordjournals.aje.a117191","key":"coi250065r22","year":"1994","issue":"11","author":"Rich-Edwards","volume":"140","first-page":"1016","unstructured":null,"article-title":"Test of the National Death Index and Equifax Nationwide Death Search.","journal-title":"Am J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.3945/jn.111.157222","key":"coi250065r23","year":"2012","issue":"6","author":"Chiuve","volume":"142","first-page":"1009","unstructured":null,"article-title":"Alternative dietary indices both strongly predict risk of chronic disease.","journal-title":"J Nutr","doi-asserted-by":"publisher"},{"DOI":"10.1097/00001648-200009000-00012","key":"coi250065r24","year":"2000","issue":"5","author":"Hernán","volume":"11","first-page":"561","unstructured":null,"article-title":"Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.","journal-title":"Epidemiology","doi-asserted-by":"publisher"},{"DOI":"10.7326/M16-2607","key":"coi250065r25","year":"2017","issue":"4","author":"VanderWeele","volume":"167","first-page":"268","unstructured":null,"article-title":"Sensitivity analysis in observational research: introducing the e-value.","journal-title":"Ann Intern Med","doi-asserted-by":"publisher"},{"DOI":"10.1097/EDE.0000000000000864","key":"coi250065r26","year":"2018","issue":"5","author":"Mathur","volume":"29","first-page":"e45","unstructured":null,"article-title":"Web site and R package for computing e-values.","journal-title":"Epidemiology","doi-asserted-by":"publisher"},{"DOI":"10.1001/jamainternmed.2016.1548","key":"coi250065r27","year":"2016","issue":"6","author":"Moore","volume":"176","first-page":"816","unstructured":null,"article-title":"Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults.","journal-title":"JAMA Intern Med","doi-asserted-by":"publisher"},{"DOI":"10.1136/bmj.l2323","key":"coi250065r28","year":"2019","issue":null,"author":"Mok","volume":"365","first-page":"l2323","unstructured":null,"article-title":"Physical activity trajectories and mortality: population based cohort study.","journal-title":"BMJ","doi-asserted-by":"publisher"},{"DOI":"10.1186/s11556-023-00316-5","key":"coi250065r29","year":"2023","issue":"1","author":"Tran","volume":"20","first-page":"4","unstructured":null,"article-title":"Trajectory of physical activity frequency and cancer risk: Findings from a population-based cohort study.","journal-title":"Eur Rev Aging Phys Act","doi-asserted-by":"publisher"},{"DOI":"10.1038/nrc2325","key":"coi250065r30","year":"2008","issue":"3","author":"McTiernan","volume":"8","first-page":"205","unstructured":null,"article-title":"Mechanisms linking physical activity with cancer.","journal-title":"Nat Rev Cancer","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10654-020-00707-3","key":"coi250065r31","year":"2021","issue":"3","author":"Lee","volume":"36","first-page":"275","unstructured":null,"article-title":"Physical activity and all-cause and cause-specific mortality: assessing the impact of reverse causation and measurement error in two large prospective cohorts.","journal-title":"Eur J Epidemiol","doi-asserted-by":"publisher"},{"DOI":"10.1200/JCO.19.02407","key":"coi250065r32","year":"2020","issue":"7","author":"Matthews","volume":"38","first-page":"686","unstructured":null,"article-title":"Amount and intensity of leisure-time physical activity and lower cancer risk.","journal-title":"J Clin Oncol","doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.109.914721","key":"coi250065r33","year":"2010","issue":"7","author":"Shiroma","volume":"122","first-page":"743","unstructured":null,"article-title":"Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity.","journal-title":"Circulation","doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,1]]}},"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["JAMA Oncology"],"published-print":{"date-parts":[[2025,12,1]]},"reference-count":33,"published-online":null,"references-count":33,"short-container-title":["JAMA Oncol"],"is-referenced-by-count":1},"unpaywall":{"doi":"10.1001/jamaoncol.2025.4185","is_oa":true,"title":"Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality","updated":"2025-12-24T00:55:44+00:00","published_date":"2025-10-30","best_oa_location":{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12576613/","pmh_id":"oai:pubmedcentral.nih.gov:12576613","url_for_pdf":null,"url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12576613/"}}},"created_at":"2026-01-11T11:19:33.869Z","updated_at":"2026-01-18T22:40:12.285Z","tags":[{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"category","value":"Oncology","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"condition","value":"Digestive System Cancer","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"sample_size","value":"n=231,067","value_numeric":231067},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"warning","value":"Dose–response and consistency modeling methods are not described in detail in the provided text.","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"warning","value":"Observational cohort design; residual confounding and measurement details are not provided in this excerpt.","value_numeric":null},{"paper_doi":"10.1001/jamaoncol.2025.4185","tag_type":"warning","value":"The comparator for “minimal activity” and covariate adjustments are not fully specified here.","value_numeric":null}],"summaries":{"what_studied":"Three large US prospective cohorts examined whether long-term consistency in meeting leisure-time physical activity guidelines (≥7.5 MET-hours/week) was associated with incident and fatal digestive system cancers over up to 32 years in 231,067 adults free of cancer and cardiovascular disease at baseline.","key_result":"Across 6,538 incident cancers and 3,791 deaths, ≥45 vs <3 MET-hours/week was linked to lower digestive system cancer incidence (HR 0.83; 95% CI, 0.74-0.93) and mortality (HR 0.72; 95% CI, 0.62-0.83); site groups showed similar inverse associations, and maintaining moderate activity consistently over 3 decades (median 16.9 MET-hours/week) lowered risk (HR 0.83; 95% CI, 0.75-0.90) without further benefit at higher amounts (median 38.5 MET-hours/week; HR 0.87; 95% CI, 0.81-0.93).","practice_takeaway":"Encourage adults to maintain guideline-level physical activity consistently over time; a steady, moderate level (~17 MET-hours/week) was associated with reduced digestive system cancer risk, and doing much more did not add extra risk reduction, though higher activity correlated with lower mortality."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Digestive System Cancer"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Digestive System Cancer"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Digestive System Cancer"}}}]]

Papers