2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T735,Gastric antral vascular ectasia (GAVE) is a cause of gastrointestinal bleeding in systemic sclerosis (SSc), but its predictors and outcomes in SSc are not fully defined. We aimed to determine the frequency of GAVE in SSc and to compare the clinical characteristics of SSc patients with versus without GAVE in a single-center Japanese cohort. We retrospectively identified SSc patients who underwent upper gastrointestinal endoscopy at our institution between 2006 and 2015. Clinical data including SSc subtype, extent of skin sclerosis, and autoantibody profiles were collected for patients with endoscopically confirmed GAVE and for those without GAVE. Of 272 SSc patients who underwent endoscopy, 19 patients (7.0%) had GAVE. SSc patients with GAVE were significantly more likely to have diffuse cutaneous SSc and had a shorter disease duration since SSc onset compared to those without GAVE. GAVE patients tended to have more severe skin sclerosis and a markedly higher prevalence of anti-RNA polymerase III antibody (42% vs. 9.5% in non-GAVE, p < 0.001), with a corresponding lower frequency of anti-centromere antibody (10.5% vs. 45.4%, p < 0.001). Scleroderma renal crisis occurred in 16% of GAVE patients versus < 1% of non-GAVE patients (p < 0.001). Follow-up endoscopy in GAVE patients showed that in roughly half of the cases the GAVE lesions disappeared over 1-8 years (often after immunosuppressive therapy), whereas the remainder had persistent GAVE changes. GAVE occurred in about 7% of SSc patients, especially those with diffuse, rapidly progressive disease. It was associated with anti-RNA polymerase III positivity and early severe organ involvement. Patients with early diffuse skin disease and this antibody may be at higher risk, highlighting the importance of early detection to prevent bleeding and anemia.31:T7d4,ABSTRACTGastric antral vascular ectasia (GAVE) is a cause of gastrointestinal bleeding in systemic sclerosis (SSc), but its predictors and outcomes in SSc are not fully defined. We aimed to determine the frequency of GAVE in SSc and to compare the clinical characteristics of SSc patients with versus without GAVE in a single‐center Japanese cohort. We retrospectively identified SSc patients who underwent upper gastrointestinal endoscopy at our institution between 2006 and 2015. Clinical data including SSc subtype, extent of skin sclerosis, and autoantibody profiles were collected for patients with endoscopically confirmed GAVE and for those without GAVE. Of 272 SSc patients who underwent endoscopy, 19 patients (7.0%) had GAVE. SSc patients with GAVE were significantly more likely to have diffuse cutaneous SSc and had a shorter disease duration since SSc onset compared to those without GAVE. GAVE patients tended to have more severe skin sclerosis and a markedly higher prevalence of anti‐RNA polymerase III antibody (42% vs. 9.5% in non‐GAVE, p < 0.001), with a corresponding lower frequency of anti‐centromere antibody (10.5% vs. 45.4%, p < 0.001). Scleroderma renal crisis occurred in 16% of GAVE patients versus < 1% of non‐GAVE patients (p < 0.001). Follow‐up endoscopy in GAVE patients showed that in roughly half of the cases the GAVE lesions disappeared over 1–8 years (often after immunosuppressive therapy), whereas the remainder had persistent GAVE changes. GAVE occurred in about 7% of SSc patients, especially those with diffuse, rapidly progressive disease. It was associated with anti‐RNA polymerase III positivity and early severe organ involvement. Patients with early diffuse skin disease and this antibody may be at higher risk, highlighting the importance of early detection to prevent bleeding and anemia.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Gastric Antral Vascular Ectasia: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Gastric Antral Vascular Ectasia (condition). Clinician-written summaries and actionable practice insights. 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Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Kenta","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Jiro","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Ko","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Motoki","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Natsumi","family":"Fushida","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Tasuku","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Kie","family":"Mizumaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Kyosuke","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]},{"given":"Yasuhito","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}]}],"issued":{"date-parts":[[2025,9,30]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2025-09-30T09:49:41Z","timestamp":1759225781000,"date-parts":[[2025,9,30]]},"indexed":{"date-time":"2025-10-01T15:53:23Z","timestamp":1759334003865,"date-parts":[[2025,10,1]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000,"date-parts":[[2025,9,30]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.17980"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-13"},{"name":"accepted","group":{"name":"publication_history","label":"Publication 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Follow-up endoscopy in GAVE cases assessed lesion persistence over 1–8 years.","key_result":"Among 272 SSc patients, 19 (7.0%) had GAVE. GAVE was associated with diffuse cutaneous SSc, shorter disease duration, higher anti–RNA polymerase III positivity (42% vs 9.5%, p<0.001), lower anti-centromere positivity (10.5% vs 45.4%, p<0.001), and more scleroderma renal crisis (16% vs <1%, p<0.001); about half of GAVE lesions disappeared on follow-up over 1–8 years, while the rest persisted.","limitations":"Retrospective, single-center design and inclusion limited to patients who underwent endoscopy may introduce selection bias. The GAVE subgroup was small (n=19), and effect sizes for disease duration and skin severity were not quantified beyond percentages.","practice_takeaway":"In SSc—especially early diffuse cutaneous disease with anti–RNA polymerase III antibodies—consider early evaluation for GAVE to prevent bleeding and anemia. Expect variable course; some lesions resolve over years, while others persist."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Gastric Antral Vascular Ectasia"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Gastric Antral Vascular Ectasia"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Gastric Antral Vascular Ectasia"}}}]]

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