2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T68e,Heart transplantation (HT) remains the reference therapy for selected eligible patients with advanced heart failure (HF), recent developments in drug and device therapies notwithstanding. The majority of heart transplants are performed in Europe and the USA. However, the rate of heart transplants varies greatly among European countries, ranging from <1 to >10 per million population per annum. Due to donor organ shortage, durable mechanical circulatory support (MCS) became a practical solution for many advanced HF patients, either as a bridge to transplant or as destination therapy. The aim of the present clinical consensus statement of the European Society of Cardiology -Heart Failure Association is to provide a perspective on important issues regarding HT, in particular patient selection, pre-transplant work-up, matching of donor heart and recipient, strategies of bridging patients to transplant with temporary or durable MCS, as well as how to increase the donor organ pool. Furthermore, surgical techniques and complications are discussed, as well as immediate post-transplant, and long-term management including the main aspects of long-term follow up such as rejection surveillance, personalized immunosuppression and managing comorbidities. Cellular and antibody mediated rejection, early cardiac allograft failure, and indications for retransplantation are described. An emphasis is given on the most important post-HT complications, such as cardiac allograft vasculopathy, infections and malignancies. Finally, the need for tailored physical rehabilitation and psychosocial support, and impact of post-transplant status on reproductive health are discussed.31:T6e3,Abstract Heart transplantation (HT) remains the reference therapy for selected eligible patients with advanced heart failure (HF), recent developments in drug and device therapies notwithstanding. The majority of heart transplants are performed in Europe and the USA. However, the rate of heart transplants varies greatly among European countries, ranging from <1 to >10 per million population per annum. Due to donor organ shortage, durable mechanical circulatory support (MCS) became a practical solution for many advanced HF patients, either as a bridge to transplant or as destination therapy. The aim of the present clinical consensus statement of the European Society of Cardiology –Heart Failure Association is to provide a perspective on important issues regarding HT, in particular patient selection, pre-transplant work-up, matching of donor heart and recipient, strategies of bridging patients to transplant with temporary or durable MCS, as well as how to increase the donor organ pool. Furthermore, surgical techniques and complications are discussed, as well as immediate post-transplant, and long-term management including the main aspects of long-term follow up such as rejection surveillance, personalized immunosuppression and managing comorbidities. Cellular and antibody mediated rejection, early cardiac allograft failure, and indications for retransplantation are described. An emphasis is given on the most important post-HT complications, such as cardiac allograft vasculopathy, infections and malignancies. Finally, the need for tailored physical rehabilitation and psychosocial support, and impact of post-transplant status on reproductive health are discussed.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Heart Transplantation: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Heart Transplantation (condition). Clinician-written summaries and actionable practice insights. 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Donors <15 years made up 1.3% of the cohort; donors 15–18 years made up 5.0%. Extreme recipient-donor age mismatches trended toward higher PGD risk (P=0.056) but did not affect mortality (P=0.88).","limitations":"- Retrospective design limits causal inference.\n- Pediatric donors <15 years were rare (n≈49), limiting statistical power for this subgroup.\n- Significant regional variation in pediatric donor use (7.64% of donors <18 in North America vs. 3.6% in Europe) may introduce selection bias.","practice_takeaway":"Carefully selected pediatric donor hearts appear safe for adult recipients, with lower PGD risk and equivalent 1-year survival compared to adult donors. Donor age should be treated as a continuous risk factor rather than a hard cutoff in donor selection decisions."}},{"doi":"10.1016/j.athoracsur.2026.05.012","pmid":"42178087","title":"Pediatric Heart Transplant Outcomes Using COVID-19-Positive Donors in the United States","journal_title":"The Annals of Thoracic Surgery","journal_issn":"0003-4975","published_at":"2026-05-23T00:00:00.000Z","url":"https://doi.org/10.1016/j.athoracsur.2026.05.012","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-03T13:44:26.380Z","updated_at":"2026-06-03T13:44:26.380Z","tags":[{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"condition","value":"Congenital Heart Disease","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"condition","value":"COVID-19","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"condition","value":"Heart Transplantation","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"generic","value":"SARS-CoV-2","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"modality","value":"Solid Organ Transplantation","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"sample_size","value":"n=2245","value_numeric":2245},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"warning","value":"Full text was not available — conclusions are based solely on the abstract and results sections provided.","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"warning","value":"Only 100 COVID-19+ donor cases were available; the study may be underpowered to detect clinically meaningful differences in rare outcomes like stroke.","value_numeric":null},{"paper_doi":"10.1016/j.athoracsur.2026.05.012","tag_type":"warning","value":"The COVID-19+ donor definition (positive test within 21 days of recovery) may not capture all nuances of active versus resolved infection at time of donation.","value_numeric":null}],"summaries":{"what_studied":"Retrospective UNOS database review comparing pediatric heart transplant outcomes (April 2020–December 2024) in recipients of COVID-19+ donor hearts (positive SARS-CoV-2 test within 21 days of recovery) versus non-COVID-19+ donor hearts, using 1:1 propensity score matching.","key_result":"1-year survival was 91.9% (COVID-19+ donors) vs 93.2% (non-COVID-19+ donors; log-rank p=0.71); COVID-19+ donor status was not associated with increased 1-year mortality (OR=0.88, 95%CI 0.36–1.85, p=0.76). Rates of stroke, dialysis, and acute rejection also did not differ significantly between groups.","limitations":"- Only 4.5% (n=100) of transplants used COVID-19+ donors, limiting statistical power to detect smaller differences.\n- Maximum follow-up was ~4.5 years with only 1-year survival reported; longer-term outcomes are unknown.\n- Retrospective registry design with potential unmeasured confounders despite propensity matching.","practice_takeaway":"COVID-19+ donor hearts appear safe for pediatric transplantation, with 1-year survival and complication rates comparable to non-COVID-19+ donors. Clinicians can consider these donors to expand the pediatric donor pool, while continuing to monitor long-term outcomes."}},{"doi":"10.1093/ejhf/xuag051","pmid":"42085519","title":"Update on heart transplantation: a clinical consensus statement of the Advanced Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology","journal_title":"European Journal of Heart Failure","journal_issn":"1388-9842","published_at":"2026-05-05T00:00:00.000Z","url":"https://doi.org/10.1093/ejhf/xuag051","source_score":44,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-09","doi":"10.1093/ejhf/xuag051","days":"7","issn":"1388-9842","rank":"6","field":"Clinical Medicine","score":"44","category":"Cardiac & Cardiovascular Systems","categories":["Cardiac & Cardiovascular Systems"],"_categories":["Cardiac & Cardiovascular Systems"]},"pubmed":{"doi":"10.1093/ejhf/xuag051","title":"Update on heart transplantation: a clinical consensus statement 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