2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6e1,Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality. This prospective study included 482 699 participants from the UK Biobank, a large-scale, population-based cohort. Sarcopenia status was assessed according to the EWGSOP2 criteria (European Working Group on Sarcopenia in Older People 2). Incident strokes were ascertained based on health records. Stroke risk was assessed using multivariable-adjusted Cox proportional hazards models, whereas poststroke mortality was compared using the Kaplan-Meier analysis with log-rank tests. A 2-sample Mendelian randomization analysis, utilizing genetic instruments from public genome-wide association studies, was conducted to infer causal associations. The cohort (mean age±SD: 56.4±8.1 years; 45.37% were men; n=219 015) had a probable sarcopenia prevalence of 4.7% and a confirmed sarcopenia prevalence of 0.4%. Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21-1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22-1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20-1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06-1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28-1.44] per 1 kg/[kg/m Sarcopenia status, lower grip strength, and slower walking pace were associated with an increased risk of incident stroke and all-cause poststroke mortality.31:Tafe, BACKGROUND: Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality. METHODS: This prospective study included 482 699 participants from the UK Biobank, a large-scale, population-based cohort. Sarcopenia status was assessed according to the EWGSOP2 criteria (European Working Group on Sarcopenia in Older People 2). Incident strokes were ascertained based on health records. Stroke risk was assessed using multivariable-adjusted Cox proportional hazards models, whereas poststroke mortality was compared using the Kaplan-Meier analysis with log-rank tests. A 2-sample Mendelian randomization analysis, utilizing genetic instruments from public genome-wide association studies, was conducted to infer causal associations. RESULTS: The cohort (mean age±SD: 56.4±8.1 years; 45.37% were men; n=219 015) had a probable sarcopenia prevalence of 4.7% and a confirmed sarcopenia prevalence of 0.4%. Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21−1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22−1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20−1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06−1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28−1.44] per 1 kg/[kg/m 2 ]) and a slow walking pace (aHR, 1.64 [95% CI, 1.54−1.75]; compared with brisk pace). Mendelian randomization analysis demonstrated that a faster walking pace was associated with a lower risk of any stroke (odds ratio, 0.94 [95% CI, 0.90−0.97] per-SD increase) and ischemic stroke (odds ratio, 0.95 [95% CI, 0.91−0.98] per-SD increase). CONCLUSIONS: Sarcopenia status, lower grip strength, and slower walking pace were associated with an increased risk of incident stroke and all-cause poststroke mortality. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Hemorrhagic Stroke: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Hemorrhagic Stroke (condition). Clinician-written summaries and actionable practice insights. 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Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21-1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22-1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20-1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06-1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28-1.44] per 1 kg/[kg/m","abstract":"$30","keywords":["hand strength","hemorrhagic stroke","ischemic stroke","sarcopenia","stroke","walking speed"],"pubmed_id":"42101654","conclusions":"","publication_date":"2026-05-08T00:00:00"},"crossref":{"DOI":"10.1161/strokeaha.125.052311","URL":"https://doi.org/10.1161/strokeaha.125.052311","ISSN":["0039-2499","1524-4628"],"link":[{"URL":"https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.125.052311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Sarcopenia, Grip Strength, Walking Pace, and New-Onset Stroke Risk: A UK Biobank Study"],"author":[{"given":"Li-Li","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Yu-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."}]},{"given":"Yu-Jia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Kai-Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou First People’s Hospital, China (Q.L.)."}]},{"given":"Zien","family":"Zhou","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (Z.Z.)."},{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (Z.Z.)."}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Bing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (B.X.)."}]},{"given":"Changzheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (C.Y.)."}]},{"given":"Lu-Sha","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]}],"issued":{"date-parts":[[2026,5,8]]},"member":"276","prefix":"10.1161","source":"Crossref","volume":null,"created":{"date-time":"2026-05-08T15:11:47Z","timestamp":1778253107000,"date-parts":[[2026,5,8]]},"indexed":{"date-time":"2026-05-13T16:08:29Z","timestamp":1778688509931,"date-parts":[[2026,5,13]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.052311"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-05-21"},{"name":"revised","group":{"name":"publication_history","label":"Publication 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Grip Strength, Walking Pace, and New-Onset Stroke Risk: A UK Biobank Study","updated":"2026-05-09T14:24:07+00:00","published_date":"2026-05-08","best_oa_location":null}},"created_at":"2026-05-14T13:22:57.575Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"category","value":"Clinical Neurology","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"condition","value":"Hemorrhagic Stroke","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"condition","value":"Ischemic Stroke","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"condition","value":"Sarcopenia","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"condition","value":"Stroke","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"modality","value":"Physical Function Assessment","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"sample_size","value":"n=482699","value_numeric":482699},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"sample_size","value":"n=482,699","value_numeric":482699},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Follow-up duration and event counts are not reported in the excerpt.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Mendelian randomization provides causal inference support for walking pace but not directly for grip strength or sarcopenia; causal claims for those variables rest on observational data only.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"'Practice_changing' flag applied cautiously — findings support adding physical function screening to stroke prevention, but formal guideline changes are pending.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Relative grip strength metric is truncated in the provided text, limiting interpretability of that effect size.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Study includes a Mendelian randomization component in addition to the cohort; design label reflects the primary cohort analysis.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"The reported cohort size in the abstract is inconsistent: the full cohort is stated as 482,699 but the results section cites n=219,015 (men only, 45.37%). The full analytic sample size should be verified in the methods.","value_numeric":null}],"summaries":{"limitations":"- Sarcopenia confirmed in only 0.4% of participants, limiting power for that subgroup.\n- UK Biobank is a volunteer cohort with known healthy-volunteer bias, which may underestimate true effect sizes.\n- Sarcopenia and muscle metrics were measured at baseline only, so changes over time are not captured.","what_studied":"A prospective UK Biobank cohort (n=482,699) assessed whether sarcopenia (EWGSOP2), grip strength, and walking pace are associated with incident stroke (any, ischemic, hemorrhagic) and poststroke all-cause mortality using multivariable Cox models and Kaplan-Meier analyses. A 2-sample Mendelian randomization was also conducted to explore causal associations.","key_result":"Probable sarcopenia (prevalence 4.7%) was associated with higher risk of any stroke (aHR 1.30, 95% CI 1.21–1.39), ischemic stroke (aHR 1.31, 95% CI 1.22–1.42), and hemorrhagic stroke (aHR 1.41, 95% CI 1.20–1.67). Each 5‑kg lower grip strength was associated with higher any-stroke risk (aHR 1.07, 95% CI 1.06–1.09); among those with stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality.","practice_takeaway":"Sarcopenia and low grip strength mark higher stroke risk and worse poststroke survival in a large population cohort; consider incorporating muscle strength and sarcopenia status into stroke risk assessment and prognostic discussions."}},{"doi":"10.1001/jamaneurol.2026.0615","pmid":"41941227","title":"Teleneurology vs On-Site Neurology Consultation for Postadmission Hospital Care of Stroke","journal_title":"JAMA Neurology","journal_issn":"2168-6149","published_at":"2026-04-06T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13054693/","source_score":35,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-17T13:29:41.776Z","updated_at":"2026-06-17T13:29:41.776Z","tags":[{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"category","value":"Clinical Neurology","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"condition","value":"Hemorrhagic Stroke","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"condition","value":"Ischemic Stroke","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"condition","value":"Transient Ischemic Attack","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"modality","value":"Telemedicine","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"sample_size","value":"n=501","value_numeric":501},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"study_design","value":"Prospective Nonrandomized Noninferiority Study","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"warning","value":"Full text was inaccessible — details on patient allocation, network neurologist credentials, video platform specifications, and adjustment for confounders could not be verified.","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"warning","value":"Level of evidence assigned as '2' based on prospective nonrandomized controlled design; some hierarchies may rate this as level 3 given absence of randomization.","value_numeric":null},{"paper_doi":"10.1001/jamaneurol.2026.0615","tag_type":"warning","value":"The study is nonrandomized; the 38-percentage-point superiority of teleneurology over on-site care is striking and may partly reflect differences in neurologist experience or documentation habits rather than care delivery mode alone.","value_numeric":null}],"summaries":{"what_studied":"This prospective, multicenter, noninferiority study compared teleneurological vs. on-site neurological ward rounds for subacute inpatient stroke care across 15 primary care hospitals in 4 German telestroke networks (October 2022–December 2024), enrolling 501 adults with ischemic stroke, hemorrhagic stroke, or TIA. The primary outcome was adherence to 6 guideline-based quality domains assessed by blinded neurovascular experts.","key_result":"Teleneurological ward rounds achieved complete adherence to all quality criteria in **92%** of cases vs. **54%** for on-site rounds (absolute difference +38 percentage points; 90% CI, 34–42), demonstrating not just noninferiority but superiority across all domains. The largest gap was in secondary prevention (+21 percentage points; 90% CI, 17–24).","limitations":"- Nonrandomized design means patient allocation to tele- vs. on-site rounds was not controlled, introducing potential selection bias.\n- Study conducted exclusively within German telestroke networks, which may limit generalizability to other health systems or telemedicine infrastructures.\n- Full text was not available for review; details on network neurologist qualifications, technical setup, and confounders are not fully assessable.","practice_takeaway":"Teleneurological ward rounds appear to outperform on-site neurology consultations for guideline adherence in subacute stroke care at primary hospitals — clinicians and health systems should consider formalizing teleneurology into routine inpatient stroke protocols, especially where local neurological expertise is scarce."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Hemorrhagic Stroke"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Hemorrhagic Stroke"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Hemorrhagic Stroke"}}}]]

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