2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T749,The 2018 European Alliance of Associations for Rheumatology (EULAR) recommendations for physical activity (PA) in people with inflammatory arthritis (IA) and osteoarthritis (OA) required revision as new studies have been published on interventions using technology and/or the combination of educational and behavioural strategies to promote PA or reduce sedentary behaviour (SB). Moreover, the World Health Organisation released updated general PA guidelines in 2020 with an emphasis on reducing SB. This work aimed to update the 2018 EULAR recommendations for PA in IA and OA. The EULAR Standardised Operating Procedures for developing recommendations were followed. A multidisciplinary task force (TF) was established. Systematic literature searches related to 13 research questions were conducted in August 2024. Recommendations were updated, and the TF members rated their level of agreement and estimated impact and implementability (0-10 scale, with 10 highest). The revised recommendations include 4 overarching principles and 11 recommendations on PA and SB including inter alia PA promotion as standard care, measurements of PA, and intervention modalities considering dose, adaptations and the application of (technology-based) behaviour change techniques. The mean level of agreement for the recommendations ranged from 9.0 to 9.8, the mean impact between 8.3 and 9.2, and the mean feasibility of implementation between 7.2 and 8.5. In addition, quality indicators, research and educational agendas were defined. The updated EULAR recommendations for PA should guide the development, conduct and evaluation of PA interventions and promotion, including the reduction of SB, in people with IA and OA. These recommendations should be implemented with consideration of individual needs, environmental conditions, and the broader national health care context.31:T610,To evaluate whether hip osteoarthritis (OA) is a risk factor for checkpoint inhibitor-induced inflammatory arthritis (ICI-IA). Patients treated for thoracic cancers with ICI therapy and with a CT of the abdomen/pelvis within one month of ICI start were included; hip OA was graded from a coronal slice of the CT by a radiologist. Chart review determined the presence of ICI-IA and other immune related adverse events Those with Kellgren-Lawrence grade of 2 or higher in either hip on CT abdomen/pelvis were classified as having hip OA. Incidence rates of ICI-IA were calculated in patients with and without hip OA. Development of ICIIA and overall survival were compared by Kaplan-Meier curves and Cox proportional hazards. A total of 309 patients were included; 103 had hip OA on CT scan. Overall, the cumulative incidence of ICI-IA was 54.8/1000 person-years and did not significantly differ between those with and without hip OA (p=0.78). In the Cox proportional hazards model for ICI-IA development, hip OA was not associated with ICI-IA development (HR 1.24, p=0.55), but higher BMI was associated with a significantly lower hazard for ICI-IA (HR 0.93, p=0.049). Survival did not differ by hip OA status but was improved in patients with ICI-IA (HR 0.59, p=0.02) and higher BMI (HR 0.97, p=0.03) and worsened in higher cancer stage (HR 1.61, p=0.003) in the multivariable analysis. CT-derived Hip OA was not significantly associated with development of ICI-IA in this cohort of lung cancer patients. ICI-IA was associated with decreased mortality.32:T857, Objective To evaluate whether hip osteoarthritis (OA) is a risk factor for checkpoint inhibitor-induced inflammatory arthritis (ICI-IA). Methods Patients treated for thoracic cancers with ICI therapy and with a CT of the abdomen/pelvis within one month of ICI start were included; hip OA was graded from a coronal slice of the CT by a radiologist. Chart review determined the presence of ICI-IA and other immune related adverse events Those with Kellgren-Lawrence grade of 2 or higher in either hip on CT abdomen/pelvis were classified as having hip OA. Incidence rates of ICI-IA were calculated in patients with and without hip OA. Development of ICIIA and overall survival were compared by Kaplan-Meier curves and Cox proportional hazards. Results A total of 309 patients were included; 103 had hip OA on CT scan. Overall, the cumulative incidence of ICI-IA was 54.8/1000 person-years and did not significantly differ between those with and without hip OA (p=0.78). In the Cox proportional hazards model for ICI-IA development, hip OA was not associated with ICI-IA development (HR 1.24, p=0.55), but higher BMI was associated with a significantly lower hazard for ICI-IA (HR 0.93, p=0.049). Survival did not differ by hip OA status but was improved in patients with ICI-IA (HR 0.59, p=0.02) and higher BMI (HR 0.97, p=0.03) and worsened in higher cancer stage (HR 1.61, p=0.003) in the multivariable analysis. Conclusion CT-derived Hip OA was not significantly associated with development of ICI-IA in this cohort of lung cancer patients. ICI-IA was associated with decreased mortality. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Inflammatory Arthritis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Inflammatory Arthritis (condition). Clinician-written summaries and actionable practice insights. 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Consensus thresholds (>70%) are convention-based and may not reflect true clinical importance.","practice_takeaway":"Program directors can use these 33 MSUS competencies as a ready-made framework to build or standardize MSUS curricula in rheumatology residency. Focus initial training on inflammatory arthritis imaging of hands, wrists, and MTP joints, plus effusion detection in knee and ankle."}},{"doi":"10.1038/s41584-026-01415-0","pmid":"42521746","title":"AI detects signs of inflammatory arthritis in hand images","journal_title":"Nature Reviews Rheumatology","journal_issn":"1759-4790","published_at":"2026-07-28T00:00:00.000Z","url":"https://doi.org/10.1038/s41584-026-01415-0","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-09T13:25:07.067Z","updated_at":"2026-08-09T13:25:07.067Z","tags":[{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"modality","value":"Artificial Intelligence / Machine Learning","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"study_design","value":"Unknown","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"warning","value":"It is unclear whether this is an original research article, a research highlight/news piece, or a review — the journal section 'Nature Reviews Rheumatology' suggests it may be a summary or commentary on another study rather than a primary research paper.","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"warning","value":"Only the paper title, DOI, journal, and publication date were provided — no abstract, methods, results, or conclusions were available. All structured fields are based solely on the title. Key result, sample size, study design, and practice takeaway could not be determined.","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01415-0","tag_type":"warning","value":"Study design and level of evidence could not be assigned without access to the full paper content.","value_numeric":null}],"summaries":{"what_studied":"This paper examines the use of artificial intelligence (AI) to detect signs of inflammatory arthritis from hand images, evaluating the potential of image-based AI tools for early identification of the condition.","limitations":"The source text provided contains only a title and metadata, with no abstract, methods, results, or conclusions available for detailed extraction."}},{"doi":"10.1038/s41584-026-01397-z","pmid":"42487016","title":"Hypoxia as an amplifier of synovial inflammation in rheumatoid arthritis","journal_title":"Nature Reviews Rheumatology","journal_issn":"1759-4790","published_at":"2026-07-22T00:00:00.000Z","url":"https://doi.org/10.1038/s41584-026-01397-z","source_score":6,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-31T13:37:01.628Z","updated_at":"2026-07-31T13:37:01.628Z","tags":[{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"modality","value":"HIF Pathway Inhibitor","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"warning","value":"No sample size is applicable — this tag was omitted accordingly.","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"warning","value":"The modality tag reflects a discussed therapeutic direction (HIF pathway targeting), not an approved or trialled intervention described in the paper.","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01397-z","tag_type":"warning","value":"This is a narrative review with no primary experimental or clinical data reported; evidence level and specific outcome numbers are not available.","value_numeric":null}],"summaries":{"what_studied":"This review examines how hypoxia amplifies synovial inflammation in rheumatoid arthritis (RA), focusing on the interplay between dysregulated angiogenesis, reactive oxygen species (ROS), metabolic reprogramming, and hypoxia-induced signalling pathways within the synovial microenvironment.","key_result":"Hypoxia in the RA synovium drives a metabolic shift in synovial cells — from a resting to a highly active state — causing accumulation of metabolic intermediates that act as pro-inflammatory signalling molecules, further perpetuating joint inflammation and destruction.","limitations":"This is a narrative review without primary data; no patient cohort or experimental model is directly reported, limiting quantitative evidence. The heterogeneity of cellular oxygen dependence across synovial tissue is acknowledged but not fully resolved mechanistically.","practice_takeaway":"Hypoxia-driven metabolic reprogramming and oxidative stress are central amplifiers of synovial inflammation in RA — targeting these pathways (e.g., HIF signalling, ROS, metabolic intermediates) may open new therapeutic avenues beyond current anti-inflammatory strategies."}},{"doi":"10.1007/s10067-026-08302-9","pmid":"42461564","title":"Association of oral outpatient antiviral medications for COVID-19 with the risk of post-acute sequelae of COVID-19 at 28 and 90 days in a cohort of individuals with systemic autoimmune rheumatic diseases","journal_title":"Clinical Rheumatology","journal_issn":"0770-3198","published_at":"2026-07-16T00:00:00.000Z","url":"https://doi.org/10.1007/s10067-026-08302-9","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-25T13:57:43.299Z","updated_at":"2026-07-25T13:57:43.299Z","tags":[{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"brand","value":"Paxlovid","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"condition","value":"Post-Acute Sequelae of COVID-19","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"condition","value":"Systemic Autoimmune Rheumatic Disease","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"generic","value":"molnupiravir","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"generic","value":"nirmatrelvir/ritonavir","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"modality","value":"Antiviral","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"sample_size","value":"n=431","value_numeric":431},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"warning","value":"Antiviral assignment was not randomized; confounding by indication (e.g., higher-risk patients more likely prescribed antivirals) may bias results in either direction.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"warning","value":"Molnupiravir and nirmatrelvir/ritonavir were analyzed together as a single 'antiviral' group, which may obscure differential effects between the two agents.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08302-9","tag_type":"warning","value":"The 90-day PASC result (aOR 0.44) is numerically promising but statistically non-significant — should not be interpreted as confirmed benefit.","value_numeric":null}],"summaries":{"practice_takeaway":"For patients with rheumatic diseases, oral COVID-19 antivirals do not clearly prevent long COVID at 28 days, but may reduce 90-day PASC risk — a finding to weigh alongside established benefits for acute disease severity. Clinicians should continue standard antiviral prescribing decisions while awaiting more definitive data in this population.","what_studied":"This prospective cohort study examined whether oral outpatient antivirals (nirmatrelvir/ritonavir or molnupiravir) reduced the risk of PASC (long COVID) at 28 and 90 days in 431 adults with systemic autoimmune rheumatic diseases (SARDs) at Mass General Brigham, from December 2021 to January 2025.","key_result":"Antiviral use showed no difference in PASC at 28 days (30.9% vs. 31.1%; aOR 0.98, 95% CI 0.64–1.49) but was associated with numerically lower odds at 90 days (5.2% vs. 10.5%; aOR 0.44, 95% CI 0.19–1.02), with the confidence interval crossing 1.","limitations":"- The 90-day result did not reach statistical significance (CI crosses 1.0), limiting firm conclusions.\n- Single health system cohort (Mass General Brigham), predominantly female (81%) and highly vaccinated (96%), limiting generalizability.\n- Observational design with potential for residual confounding by indication (sicker patients may have been more likely to receive antivirals)."}},{"doi":"10.1038/s41584-026-01403-4","pmid":"42393391","title":"Joint-specific susceptibility to inflammation is determined in utero","journal_title":"Nature Reviews Rheumatology","journal_issn":"1759-4790","published_at":"2026-07-02T00:00:00.000Z","url":"https://doi.org/10.1038/s41584-026-01403-4","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-07T13:26:17.119Z","updated_at":"2026-07-07T13:26:17.119Z","tags":[{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"study_design","value":"Review","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01403-4","tag_type":"warning","value":"Only bibliographic metadata was provided — no abstract, methods, results, or conclusions were available. All structured fields are inferred from the title alone. Key result, sample size, sex, modality, and practice takeaway could not be determined. The study design is assumed to be a review based on publication in Nature Reviews Rheumatology, but this is unconfirmed.","value_numeric":null}],"summaries":{"what_studied":"This paper investigates whether joint-specific susceptibility to inflammatory arthritis is determined during fetal (in utero) development, exploring how prenatal biological programming may shape which joints are vulnerable to inflammation later in life.","limitations":"The paper text provided contains only metadata (title, DOI, journal, date) without access to the full abstract or results, preventing extraction of specific findings, sample sizes, or quantitative outcomes."}},{"doi":"10.1038/s41590-026-02542-2","pmid":"42260300","title":"The embryonic origins of site-specific arthritis","journal_title":"Nature Immunology","journal_issn":"1529-2908","published_at":"2026-06-08T00:00:00.000Z","url":"https://doi.org/10.1038/s41590-026-02542-2","source_score":19,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-16T13:54:31.110Z","updated_at":"2026-06-16T13:54:31.110Z","tags":[{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"age_group","value":"neonate","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"category","value":"Immunology","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"modality","value":"Single-Cell RNA Sequencing","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"modality","value":"X-Ray Tomography","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"study_design","value":"Translational/Mechanistic Study","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"warning","value":"Sample sizes for individual joint comparisons are not explicitly stated in the available text, so a sample_size tag could not be assigned with confidence.","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"warning","value":"Sex of the fetal samples is not reported in the abstract or methods excerpt, so the 'sex' tag is omitted.","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"warning","value":"Study design is primarily descriptive/mechanistic using fetal human tissue; no standard clinical trial design applies — 'Translational/Mechanistic Study' is used and level of evidence is approximate.","value_numeric":null},{"paper_doi":"10.1038/s41590-026-02542-2","tag_type":"warning","value":"The 'practice_changing' impact flag reflects the novelty of the embryonic origin hypothesis for site-specific arthritis, but clinical translation is speculative at this stage.","value_numeric":null}],"summaries":{"what_studied":"This study examined why proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis compared to distal interphalangeal (DIP) joints in human fingers, using single-cell RNA sequencing, imaging, and synchrotron X-ray tomography of fetal finger joints during development.","key_result":"PIP joints had a larger synovial volume and were enriched for PI16+ 'universal' fibroblasts located in perivascular regions and at tendon-ligament interfaces. These PI16+ fibroblasts showed both shared inflammatory and cell-type-specific transcriptional responses to cytokine (TNF, IL-1β) stimulation, implicating them as drivers of site-specific inflammation susceptibility.","limitations":"- Study uses fetal/embryonic tissue, so direct causal links to adult inflammatory arthritis require further validation.\n- Contaminating tenocytes were found in 3 of 7 PIP samples, introducing potential noise in the stromal cell analysis.\n- The functional consequences of PI16+ fibroblast enrichment at PIP joints are inferred from transcriptional data rather than in vivo arthritis models.","practice_takeaway":"The embryonic stoichiometry of PI16+ fibroblasts may determine which joints are vulnerable to inflammation later in life — a finding that could eventually guide tissue-specific targeting strategies in inflammatory arthritis. Clinicians should be aware that joint-site susceptibility in conditions like RA may have developmental, not just immunological, roots."}},{"doi":"10.1016/s2665-9913(26)00144-x","pmid":"42208950","title":"Health literacy and outcomes in people with inflammatory arthritis","journal_title":"The Lancet Rheumatology","journal_issn":"2665-9913","published_at":"2026-05-28T00:00:00.000Z","url":"https://doi.org/10.1016/s2665-9913(26)00144-x","source_score":4,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-25T13:57:51.731Z","updated_at":"2026-07-25T13:57:51.731Z","tags":[{"paper_doi":"10.1016/s2665-9913(26)00144-x","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00144-x","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00144-x","tag_type":"study_design","value":"Observational Study","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00144-x","tag_type":"warning","value":"Only bibliographic metadata was provided for this paper — no abstract, methods, results, or full text were available. All structured summary fields requiring specific data (key results, limitations, practice takeaway, sample size, age group, sex, level of evidence) cannot be populated without speculation. The study design tag is a best guess based on context.","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00144-x","tag_type":"warning","value":"The DOI resolves to a 2026 publication; full text was not accessible for extraction.","value_numeric":null}],"summaries":{"what_studied":"The paper examines the relationship between health literacy and clinical/patient-reported outcomes in people with inflammatory arthritis, likely evaluating how health literacy levels affect disease management and quality of life."}},{"doi":"10.1016/s2665-9913(26)00081-0","pmid":"42208951","title":"The role of health literacy in clinical, treatment, and work-related outcomes in people with inflammatory arthritis in England: a cross-sectional study","journal_title":"The Lancet Rheumatology","journal_issn":"2665-9913","published_at":"2026-05-28T00:00:00.000Z","url":"https://doi.org/10.1016/s2665-9913(26)00081-0","source_score":37,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-24T13:38:10.513Z","updated_at":"2026-07-24T13:38:10.513Z","tags":[{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"condition","value":"Depression","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"generic","value":"corticosteroid","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"modality","value":"Corticosteroid","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"sample_size","value":"n=995","value_numeric":995},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1016/s2665-9913(26)00081-0","tag_type":"warning","value":"Median age of 59 years (IQR 50–67) skews toward older adults; findings may not generalize to younger inflammatory arthritis populations. The 'impact_flag' of practice_changing reflects the strong, consistent associations across all 9 health literacy domains, though causality cannot be established from this cross-sectional design. The study includes multiple inflammatory arthritis subtypes beyond rheumatoid arthritis but does not report separate subgroup results.","value_numeric":null}],"summaries":{"what_studied":"This cross-sectional study examined associations between health literacy (measured across 9 domains), social determinants of health, and clinical, mental health, and work-related outcomes in 995 adults with confirmed inflammatory arthritis enrolled in England's National Early Inflammatory Arthritis Audit (NEIAA), surveyed March–May 2024.","key_result":"Lower health literacy across all 9 domains was linked to higher self-reported disease activity (strongest association: insufficient information to self-manage, β −17.04 [95% CI −20.69 to −13.39]), greater depression symptoms (β −0.93 [95% CI −1.13 to −0.74] for same domain), higher comorbidity burden, and higher corticosteroid use (RR 0.56 [0.43–0.73] for poor ability to find health information); employment status was not significantly associated with most health literacy domains.","limitations":"Cross-sectional design precludes causal inference. Self-reported disease activity and online survey format may introduce bias, and the sample may over-represent more health-literate or digitally engaged patients.","practice_takeaway":"Screen for health literacy in inflammatory arthritis patients, especially those with high disease activity or depression — improving access to clear, actionable health information may be a modifiable lever for better outcomes. Be aware that patients with lower health literacy may also be receiving more corticosteroids, suggesting suboptimal disease management."}},{"doi":"10.1002/art.70191","pmid":"42007808","title":"Clinical Images: Bone repair of atlantoaxial joint destruction with IL‐6 blockade","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-05-06T00:00:00.000Z","url":"https://doi.org/10.1002/art.70191","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-04T13:23:37.736Z","updated_at":"2026-06-04T13:23:37.736Z","tags":[{"paper_doi":"10.1002/art.70191","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"condition","value":"Atlantoaxial Joint Destruction","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"modality","value":"IL-6 Receptor Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"sample_size","value":"n=1","value_numeric":1},{"paper_doi":"10.1002/art.70191","tag_type":"study_design","value":"Case Report","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"warning","value":"Age group and sex of the patient could not be determined from the available information.","value_numeric":null},{"paper_doi":"10.1002/art.70191","tag_type":"warning","value":"This is a clinical image/case report with very limited detail available from the metadata alone; specific drug name (brand/generic IL-6 blocker), patient demographics, and imaging modality used are not specified in the provided source text.","value_numeric":null}],"summaries":{"what_studied":"A clinical image report documenting bone repair of atlantoaxial joint destruction following IL-6 blockade therapy in a patient with inflammatory arthritis.","key_result":"Imaging demonstrated bone repair at the atlantoaxial joint after treatment with IL-6 blockade, suggesting structural benefit beyond symptom control.","limitations":"Case report format limits generalizability; no control comparator; single patient, so causal inference is constrained.","practice_takeaway":"IL-6 blockade may promote structural bone repair at the atlantoaxial joint in inflammatory arthritis — a rare but serious site of involvement worth monitoring with imaging in treated patients."}},{"doi":"10.1002/art.70131","pmid":"41838025","title":"Telocyte Deletion Associated With Loss of Lymphatic Drainage and Exacerbation of Inflammatory‐Erosive Arthritis in Mice","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1002/art.70131","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-08T13:23:39.505Z","updated_at":"2026-05-08T13:23:39.505Z","tags":[{"paper_doi":"10.1002/art.70131","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"level_of_evidence","value":"6","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"modality","value":"Cell Biology / Gene Targeting","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"modality","value":"Lymphatic Imaging","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"study_design","value":"Preclinical Animal Study","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"warning","value":"No human subjects were studied; all findings are from a murine zymosan-induced arthritis model — clinical translation is speculative at this stage.","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"warning","value":"Sample sizes for individual experimental groups are not reported in the abstract; effect sizes should be interpreted with caution.","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"warning","value":"Study design tag 'Preclinical Animal Study' is used as this does not fit standard RCT/observational hierarchies; level of evidence set to 6 accordingly.","value_numeric":null},{"paper_doi":"10.1002/art.70131","tag_type":"warning","value":"The 'practice_changing' flag reflects novelty of telocytes as a drug target concept, not a change in current clinical practice — no new therapy is available.","value_numeric":null}],"summaries":{"what_studied":"This mouse study investigated the role of telocytes — peri-lymphatic spindle-shaped cells — in joint-draining lymphatic function during zymosan-induced arthritis (ZIA), using novel transgenic lines (Efhd1-CreERT2 and Myoc-CreERT2) for targeted telocyte labeling and diphtheria toxin–mediated depletion.","key_result":"Telocyte depletion reduced lymphatic drainage (measured by near-infrared indocyanine green imaging) and worsened synovitis and focal bone erosions in ZIA; telocyte networks were found to physically integrate with mast cells and extend from ankle synovium capillaries to collecting lymphatic vessels near the knee.","limitations":"Findings are from a mouse arthritis model (ZIA) and may not directly translate to human RA; the functional mechanism linking telocyte loss to impaired lymphatic contractions is not fully elucidated; no direct human telocyte data are presented.","practice_takeaway":"Telocytes near joint-draining lymphatics appear to be critical for synovial fluid drainage and limiting joint damage. While no clinical intervention is ready, the authors suggest exercise — known to preserve telocytes — as a potentially meaningful adjunct in RA management pending further study."}},{"doi":"10.1016/j.ard.2026.03.006","pmid":"42036268","title":"EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis: 2025 update","journal_title":"Annals of the Rheumatic Diseases","journal_issn":"0003-4967","published_at":"2026-04-27T00:00:00.000Z","url":"https://doi.org/10.1016/j.ard.2026.03.006","source_score":65,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-30","doi":"10.1016/j.ard.2026.03.006","days":"14","issn":"0003-4967","rank":"1","field":"Clinical Medicine","score":"65","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":{"doi":"10.1016/j.ard.2026.03.006","title":"EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis: 2025 update.","journal":"Annals of the rheumatic diseases","methods":"","results":"The revised recommendations include 4 overarching principles and 11 recommendations on PA and SB including inter alia PA promotion as standard care, measurements of PA, and intervention modalities considering dose, adaptations and the application of (technology-based) behaviour change techniques. The mean level of agreement for the recommendations ranged from 9.0 to 9.8, the mean impact between 8.3 and 9.2, and the mean feasibility of implementation between 7.2 and 8.5. 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update","updated":"2026-05-03T08:48:54+00:00","published_date":"2026-04-01","best_oa_location":{"url":"https://ard.eular.org/article/S0003-4967(26)00150-0/pdf","pmh_id":null,"url_for_pdf":"https://ard.eular.org/article/S0003-4967(26)00150-0/pdf","url_for_landing_page":"https://doi.org/10.1016/j.ard.2026.03.006"}}},"created_at":"2026-05-07T22:49:43.330Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"condition","value":"Osteoarthritis","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"modality","value":"Behaviour Change Techniques","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"modality","value":"Physical Activity Intervention","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"modality","value":"Technology-Based Intervention","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"study_design","value":"Clinical Practice Guideline","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"warning","value":"Level of evidence assigned as '3' reflects expert consensus and systematic literature review methodology typical of EULAR guidelines; the paper does not explicitly state an evidence level.","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"warning","value":"No sample size is reported; this is a guideline/recommendation document, not a primary clinical trial.","value_numeric":null},{"paper_doi":"10.1016/j.ard.2026.03.006","tag_type":"warning","value":"The DOI and publication date (2026) are ahead of typical indexing timelines — content has been treated as published per the provided metadata.","value_numeric":null}],"summaries":{"what_studied":"A multidisciplinary EULAR task force updated the 2018 recommendations for physical activity (PA) and sedentary behaviour (SB) in people with inflammatory arthritis (IA) and osteoarthritis (OA), incorporating new evidence from technology-based and behavioural interventions and the 2020 WHO PA guidelines, based on systematic literature searches (August 2024).","key_result":"The update produced 4 overarching principles and 11 recommendations covering PA promotion as standard care, PA measurement, intervention dose/adaptations, and behaviour change techniques (including technology-based). Mean task force agreement ranged from 9.0–9.8/10, mean impact 8.3–9.2/10, and mean feasibility of implementation 7.2–8.5/10.","limitations":"Recommendations are consensus-based with task force ratings rather than direct patient outcome data; implementability scores (as low as 7.2/10) suggest real-world adoption may vary by healthcare context and resources.","practice_takeaway":"Clinicians managing IA or OA should treat PA promotion — including reduction of sedentary time — as standard care, using behaviour change techniques and technology-based tools tailored to individual needs. Implementation should account for local healthcare context and patient-specific factors."}},{"doi":"10.1002/art.70108","pmid":"41968960","title":"PEPITEM\n Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-04-13T00:00:00.000Z","url":"https://doi.org/10.1002/art.70108","source_score":84,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:49:26.464Z","updated_at":"2026-05-07T22:49:26.464Z","tags":[{"paper_doi":"10.1002/art.70108","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"generic","value":"PEPITEM","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"modality","value":"Peptide Therapy","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"study_design","value":"Translational Study (Human Biomarker + Preclinical Animal Models)","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"warning","value":"No specific sample sizes (n) are reported in the abstract or results for the human clinical cohort, limiting assessment of statistical power.","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"warning","value":"PEPITEM is an investigational peptide with no current approved clinical use; the 'practice takeaway' reflects future potential only.","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"warning","value":"Study design is mixed (human biomarker data + mouse models); level of evidence reflects the preclinical nature of the therapeutic efficacy data.","value_numeric":null},{"paper_doi":"10.1002/art.70108","tag_type":"warning","value":"'Translational Study' is used as the study design label due to the hybrid human/animal design — no standard canonical label fully captures this.","value_numeric":null}],"summaries":{"what_studied":"This study investigated the adiponectin-PEPITEM pathway in treatment-naive patients with early rheumatoid arthritis (RA) and psoriatic arthritis (PsA), and assessed the therapeutic effect of exogenous PEPITEM in three preclinical inflammatory arthritis mouse models using histology, single-cell RNA sequencing, flow cytometry, and multiplex analysis.","key_result":"Newly diagnosed RA and PsA patients showed significantly reduced adiponectin receptor 2 and APPL-1 expression on PBMCs, lowering synovial PEPITEM levels. In all three animal models, PEPITEM treatment significantly reduced arthritis severity, joint swelling, leukocyte infiltration, and pro-inflammatory mediators (CCL2, RANTES, IL-16), via suppression of COX-2 and NF-κB signaling.","limitations":"Preclinical efficacy data are from mouse models only — human therapeutic dosing and safety are not yet established. The study does not report specific sample sizes or quantitative effect sizes for the clinical cohort. Mechanistic findings rely on animal models that may not fully replicate human RA or PsA pathophysiology.","practice_takeaway":"The adiponectin-PEPITEM pathway is measurably impaired early in RA and PsA, before treatment begins. Clinicians should watch for PEPITEM-based therapies entering trials as a potential adjunct or alternative in early immune-mediated inflammatory arthritis."}},{"doi":"10.3899/jrheum.2025-0808","pmid":"41539725","title":"Hip osteoarthritis is not a risk factor for immune checkpoint inhibitor-induced inflammatory arthritis","journal_title":"The Journal of Rheumatology","journal_issn":"0315-162X","published_at":"2026-01-16T00:00:00.000Z","url":"https://doi.org/10.3899/jrheum.2025-0808","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-18","doi":"10.3899/jrheum.2025-0808","days":"7","issn":"0315-162X","rank":"6","field":"Clinical Medicine","score":"7","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":{"doi":"10.3899/jrheum.2025-0808","title":"Hip osteoarthritis is not a risk factor for immune checkpoint inhibitor-induced inflammatory arthritis.","journal":"The Journal of rheumatology","methods":"","results":"A total of 309 patients were included; 103 had hip OA on CT scan. Overall, the cumulative incidence of ICI-IA was 54.8/1000 person-years and did not significantly differ between those with and without hip OA (p=0.78). In the Cox proportional hazards model for ICI-IA development, hip OA was not associated with ICI-IA development (HR 1.24, p=0.55), but higher BMI was associated with a significantly lower hazard for ICI-IA (HR 0.93, p=0.049). Survival did not differ by hip OA status but was improved in patients with ICI-IA (HR 0.59, p=0.02) and higher BMI (HR 0.97, p=0.03) and worsened in higher cancer stage (HR 1.61, p=0.003) in the multivariable analysis.","abstract":"$31","keywords":[],"pubmed_id":"41539725","conclusions":"CT-derived Hip OA was not significantly associated with development of ICI-IA in this cohort of lung cancer patients. ICI-IA was associated with decreased mortality.","publication_date":"2026-01-16T00:00:00"},"crossref":{"DOI":"10.3899/jrheum.2025-0808","URL":"https://doi.org/10.3899/jrheum.2025-0808","ISSN":["0315-162X","1499-2752","0315-162X"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.3899/jrheum.2025-0808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"jrheum.2025-0808","type":"journal-article","issue":null,"score":1,"title":["Hip osteoarthritis is not a risk factor for immune checkpoint inhibitor-induced inflammatory arthritis"],"author":[{"given":"Rebecca","family":"Fitzpatrick","sequence":"first","affiliation":[]},{"given":"Shadpour","family":"Demehri","sequence":"additional","affiliation":[]},{"given":"Joseph","family":"Murray","sequence":"additional","affiliation":[]},{"given":"Julie R.","family":"Brahmer","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Ghotbi","sequence":"additional","affiliation":[]},{"given":"Durrant","family":"Barasa","sequence":"additional","affiliation":[]},{"given":"Clifton O.","family":"Bingham","sequence":"additional","affiliation":[]},{"given":"Ami A.","family":"Shah","sequence":"additional","affiliation":[]},{"given":"Laura C.","family":"Cappelli","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1,15]]},"member":"2262","prefix":"10.3899","source":"Crossref","volume":null,"created":{"date-time":"2026-01-15T13:25:15Z","timestamp":1768483515000,"date-parts":[[2026,1,15]]},"indexed":{"date-time":"2026-01-16T06:45:32Z","timestamp":1768545932665,"date-parts":[[2026,1,16]]},"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"http://www.jrheum.org/lookup/doi/10.3899/jrheum.2025-0808"}},"subtitle":[],"deposited":{"date-time":"2026-01-15T13:25:16Z","timestamp":1768483516000,"date-parts":[[2026,1,15]]},"issn-type":[{"type":"print","value":"0315-162X"},{"type":"electronic","value":"1499-2752"},{"type":"print","value":"0315-162X"}],"published":{"date-parts":[[2026,1,15]]},"publisher":"The Journal of Rheumatology","reference":null,"short-title":[],"alternative-id":["10.3899/jrheum.2025-0808"],"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["The Journal of Rheumatology"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,15]]},"references-count":0,"short-container-title":["J Rheumatol"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.3899/jrheum.2025-0808","is_oa":false,"title":"Hip osteoarthritis is not a risk factor for immune checkpoint inhibitor-induced inflammatory arthritis","updated":"2026-01-17T01:14:18+00:00","published_date":"2026-01-15","best_oa_location":null}},"created_at":"2026-01-20T15:55:50.695Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"condition","value":"Inflammatory Arthritis","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"condition","value":"Lung Cancer","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"condition","value":"Osteoarthritis of Hip","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"modality","value":"Immune Checkpoint Inhibitor","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"sample_size","value":"n=309","value_numeric":309},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"warning","value":"Population is described as thoracic cancers in methods but as lung cancer in conclusions, creating scope ambiguity.","value_numeric":null},{"paper_doi":"10.3899/jrheum.2025-0808","tag_type":"warning","value":"Study design is not explicitly labeled; classification as a retrospective cohort is inferred from chart review and imaging assessment.","value_numeric":null}],"summaries":{"what_studied":"A cohort of 309 patients with thoracic cancers starting immune checkpoint inhibitors who had a CT abdomen/pelvis within 1 month was analyzed. Hip osteoarthritis (Kellgren-Lawrence ≥2 on either hip) was graded on a coronal CT slice; development of immune checkpoint inhibitor–induced inflammatory arthritis (ICI-IA) and survival were compared by hip OA status using Kaplan-Meier and Cox models.","key_result":"ICI-IA incidence was 54.8 per 1000 person-years and did not differ by hip OA status (p=0.78). Hip OA was not associated with ICI-IA (HR 1.24, p=0.55), whereas higher BMI lowered ICI-IA risk (HR 0.93, p=0.049); ICI-IA was associated with better survival (HR 0.59, p=0.02).","limitations":"Sample limited to thoracic cancer patients with baseline CT within 1 month of ICI start; hip OA graded from a single coronal CT slice using Kellgren-Lawrence criteria; ICI-IA and immune events were ascertained by chart review.","practice_takeaway":"Hip osteoarthritis on CT does not predict risk of ICI-induced inflammatory arthritis in lung/thoracic cancer patients on checkpoint inhibitors; monitor for ICI-IA regardless of baseline hip OA."}}],"initialOffset":13,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Inflammatory Arthritis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Inflammatory Arthritis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Inflammatory Arthritis"}}}]]

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