2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6c4,This study aimed to characterize conflict of interest disclosure practices in trials and guidelines recommending corticosteroid injections for knee osteoarthritis. Three databases (Cumulative Index to Nursing and Allied Health Literature, Ovid MEDLINE ALL, and Embase) were queried for randomized controlled trials from inception to April 2025 that assessed corticosteroid injection treatment effect for knee osteoarthritis. Clinical practice guidelines were retrieved from a recent systematic review. Study details, authors, affiliations, and conflict of interest disclosures were extracted. Transparency and appropriateness with addressing disclosures were assessed for every manuscript and disclosures were examined and compared with three national public conflict of interest disclosure databases. All conflicts were categorized and proportions calculated. Seventy-five trials and 14 guidelines were included. Twenty-nine percent of trials (n=22) and 14.3% of guidelines (n=2) had no conflict of interest statement. Ten trials (13.3%) and six guidelines (42.9%) reported a conflict of interest for at least one author. Eleven trials (14.7%) and six guidelines (42.9%) had discrepancies between disclosures in manuscripts versus reports in public databases. Forty-three trial authors (34.1%) and 19 (9.4%) guideline authors had discrepancies between disclosures in the manuscripts versus public databases. Conflict of interest reporting practices in trials and guidelines assessing effectiveness of corticosteroid injections for knee osteoarthritis are poor with a lack of transparency. Quality and thoroughness with reporting conflicts of interest is necessary to best understand industry influence on treatment recommendations.31:Taf5, Objective This study aimed to characterize conflict of interest disclosure practices in trials and guidelines recommending corticosteroid injections for knee osteoarthritis. Methods Three databases (Cumulative Index to Nursing and Allied Health Literature, Ovid MEDLINE ALL, and Embase) were queried for randomized controlled trials from inception to April 2025 that assessed corticosteroid injection treatment effect for knee osteoarthritis. Clinical practice guidelines were retrieved from a recent systematic review. Study details, authors, affiliations, and conflict of interest disclosures were extracted. Transparency and appropriateness with addressing disclosures were assessed for every manuscript and disclosures were examined and compared with three national public conflict of interest disclosure databases. All conflicts were categorized and proportions calculated. Results Seventy‐five trials and 14 guidelines were included. Twenty‐nine percent of trials (n=22) and 14.3% of guidelines (n=2) had no conflict of interest statement. Ten trials (13.3%) and six guidelines (42.9%) reported a conflict of interest for at least one author. Eleven trials (14.7%) and six guidelines (42.9%) had discrepancies between disclosures in manuscripts versus reports in public databases. Forty‐three trial authors (34.1%) and 19 (9.4%) guideline authors had discrepancies between disclosures in the manuscripts versus public databases. Conclusion Conflict of interest reporting practices in trials and guidelines assessing effectiveness of corticosteroid injections for knee osteoarthritis are poor with a lack of transparency. Quality and thoroughness with reporting conflicts of interest is necessary to best understand industry influence on treatment recommendations.

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32:T65d,There is an urgent need to identify clinical markers that can help physicians determine when additional treatment is necessary to manage the symptoms of knee osteoarthritis (OA). Patterns of physical activity that occur within a day, e.g., low activity in the morning and/or evening, may be a novel means to identify treatment need, given that symptoms may reduce daily activity at specific times of the day. The purpose of this study is to explore the relationship between within-day patterns of physical activity and all-cause mortality in adults with or at high risk for knee OA. We performed a secondary analysis of the Osteoarthritis Initiative (NCT00080171). Our exposure was within-day patterns of physical activity using a Multidimensional (14-hour) Multilevel (4-day) Functional Principal Component Analysis to analyze accelerometer data from analytic baseline. The outcome was all-cause mortality assessed up to 8 years. Kaplan-Meier survival curves and Cox Proportional Hazards regressions were used to calculate adjusted Hazard Ratios (aHR). There were 1927 adults with or at high risk for knee OA included in this analysis. We identified 4 primary within-day activity patterns accounting for ~82% of sample variability. Participants who demonstrated low levels of activity in the morning and evening had 2.09 times the risk of mortality compared to those demonstrating the average activity pattern of the sample (aHR 2.09, 95% CI [1.15, 3.80]). Unique within-day patterns of physical activity were associated with mortality risk. Those with inactivity in the morning and evening were at increased risk for mortality.33:Ta9a, Objective There is an urgent need to identify clinical markers that can help physicians determine when additional treatment is necessary to manage the symptoms of knee osteoarthritis (OA). Patterns of physical activity that occur within a day, e.g., low activity in the morning and/or evening, may be a novel means to identify treatment need, given that symptoms may reduce daily activity at specific times of the day. The purpose of this study is to explore the relationship between within‐day patterns of physical activity and all‐cause mortality in adults with or at high risk for knee OA. Methods We performed a secondary analysis of the Osteoarthritis Initiative (NCT00080171). Our exposure was within‐day patterns of physical activity using a Multidimensional (14‐hour) Multilevel (4‐day) Functional Principal Component Analysis to analyze accelerometer data from analytic baseline. The outcome was all‐cause mortality assessed up to 8 years. Kaplan‐Meier survival curves and Cox Proportional Hazards regressions were used to calculate adjusted Hazard Ratios (aHR). Results There were 1927 adults with or at high risk for knee OA included in this analysis. We identified 4 primary within‐day activity patterns accounting for ~82% of sample variability. Participants who demonstrated low levels of activity in the morning and evening had 2.09 times the risk of mortality compared to those demonstrating the average activity pattern of the sample (aHR 2.09, 95% CI [1.15, 3.80]). Conclusion Unique within‐day patterns of physical activity were associated with mortality risk. Those with inactivity in the morning and evening were at increased risk for mortality.

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34:T649,Osteoarthritis (OA) is a prevalent, debilitating and costly chronic condition. National and international guidelines recommend the conservative treatment strategies of body mass reduction and exercise for the management of hip and knee OA because of the strong evidence to support the efficacy of these interventions. Despite this, these conservative management strategies are currently underutilised in Australia. Appropriately designed, novel models of care may play a role in improving the utilisation of appropriate conservative treatment strategies for hip and knee OA. Therefore, a qualitative study was conducted to investigate patient and clinician perspectives of a novel multidisciplinary case conference model to conservatively manage hip and knee OA within a primary care setting. Qualitative data were collected via telephone-based semi-structured one-on-one interviews with patients with OA (n = 11), general practitioners (n = 2), accredited exercise physiologists (n = 2), accredited practising dietitians (n = 2) and practice nurses (n = 2). Thematic content analysis led to the generation of four major themes from the data: (i) potential benefits; (ii) foreseeable challenges; (iii) the benefit-engagement cycle and (iv) maintenance of lifestyle changes. The proposed multidisciplinary model of care to conservatively manage hip and knee OA was perceived by both patients and clinicians to have many benefits and a limited number of manageable challenges. The identified challenges provide guidance on how the model should be refined before it is implemented in clinical practice.35:T891, Background Osteoarthritis (OA) is a prevalent, debilitating and costly chronic condition. National and international guidelines recommend the conservative treatment strategies of body mass reduction and exercise for the management of hip and knee OA because of the strong evidence to support the efficacy of these interventions. Despite this, these conservative management strategies are currently underutilised in Australia. Appropriately designed, novel models of care may play a role in improving the utilisation of appropriate conservative treatment strategies for hip and knee OA. Therefore, a qualitative study was conducted to investigate patient and clinician perspectives of a novel multidisciplinary case conference model to conservatively manage hip and knee OA within a primary care setting. Methods Qualitative data were collected via telephone-based semi-structured one-on-one interviews with patients with OA (n = 11), general practitioners (n = 2), accredited exercise physiologists (n = 2), accredited practising dietitians (n = 2) and practice nurses (n = 2). Results Thematic content analysis led to the generation of four major themes from the data: (i) potential benefits; (ii) foreseeable challenges; (iii) the benefit-engagement cycle and (iv) maintenance of lifestyle changes. Conclusion The proposed multidisciplinary model of care to conservatively manage hip and knee OA was perceived by both patients and clinicians to have many benefits and a limited number of manageable challenges. The identified challenges provide guidance on how the model should be refined before it is implemented in clinical practice. 36:T7d6,This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self-reported outcomes in young adults following traumatic knee injury. One year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years old) self-reported the presence and/or absence of knee crepitus using an item from the Knee Injury and Osteoarthritis Outcome Score (KOOS). Patellofemoral and tibiofemoral osteoarthritis features (ie, cartilage lesions, osteophytes, and bone marrow lesions) were assessed from magnetic resonance imaging scans at one and five years after ACLR. Self-reported outcomes were assessed with two KOOS subscales (pain and quality of life [QoL]) and the International Knee Documentation Committee subjective evaluation form (ie, self-reported function). Poisson regression evaluated the relationship between self-reported crepitus and the presence/worsening of structural osteoarthritis features. General linear models explored the relationship between crepitus and self-reported outcomes. Self-reported crepitus was associated with full-thickness patellofemoral cartilage lesions one year after ACLR (prevalence ratio 2.70, 95% confidence interval [CI] 1.41-6.39) but not the risk of worsening structural osteoarthritis features between one and five years after ACLR. Those with crepitus reported worse pain (β = -6.42, 95% CI -10.47 to -2.36), QoL (β = -10.39, 95% CI -18.58 to -2.20), and function (β = -5.49, 95% CI -10.92 to -0.06) one year after ACLR but greater improvement in pain and function between one and five years. Self-reported knee crepitus was associated with the presence of full-thickness patellofemoral cartilage defects one year after ACLR but was not associated with a greater risk of worsening structural osteoarthritis features up to five years after ACLR. One year after ACLR, those with crepitus reported worse pain, knee-related QoL, and function.37:Ta47, Objective This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self‐reported outcomes in young adults following traumatic knee injury. Methods One year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years old) self‐reported the presence and/or absence of knee crepitus using an item from the Knee Injury and Osteoarthritis Outcome Score (KOOS). Patellofemoral and tibiofemoral osteoarthritis features (ie, cartilage lesions, osteophytes, and bone marrow lesions) were assessed from magnetic resonance imaging scans at one and five years after ACLR. Self‐reported outcomes were assessed with two KOOS subscales (pain and quality of life [QoL]) and the International Knee Documentation Committee subjective evaluation form (ie, self‐reported function). Poisson regression evaluated the relationship between self‐reported crepitus and the presence/worsening of structural osteoarthritis features. General linear models explored the relationship between crepitus and self‐reported outcomes. Results Self‐reported crepitus was associated with full‐thickness patellofemoral cartilage lesions one year after ACLR (prevalence ratio 2.70, 95% confidence interval [CI] 1.41–6.39) but not the risk of worsening structural osteoarthritis features between one and five years after ACLR. Those with crepitus reported worse pain (β = −6.42, 95% CI −10.47 to −2.36), QoL (β = −10.39, 95% CI −18.58 to −2.20), and function (β = −5.49, 95% CI −10.92 to −0.06) one year after ACLR but greater improvement in pain and function between one and five years. Conclusion Self‐reported knee crepitus was associated with the presence of full‐thickness patellofemoral cartilage defects one year after ACLR but was not associated with a greater risk of worsening structural osteoarthritis features up to five years after ACLR. One year after ACLR, those with crepitus reported worse pain, knee‐related QoL, and function. 38:T67b,This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals. A retrospective study was conducted using electronic medical records from an integrated health care system in the United States. Incident KOA visits between October 2016 and September 2017 were identified using International Classification of Diseases, Tenth Revision codes. Early PT referral was defined as a referral within 15 days of the incident KOA visit by the attending physician. Data on PT referrals, other KOA treatments, patient characteristics, physician specialty, practice location, and volume of patients with KOA were extracted. The number of licensed PTs within the county of the included practices was also obtained. We used generalized linear mixed models to predict factors associated with early PT referrals. Included in our study were 9,835 patients with incident KOA. Within the 12-month period, 26% of patients had at least one PT referral (n = 2,550) and the median (interquartile range) days to the first referral was 0 (0-34) days. Early PT referral by the index physician occurred in 16.5% (n = 1,629) of patients, was less likely for patients with higher or missing knee pain scores and in rural practices, and more likely in women, patients with higher body mass index, and those seen in counties with a greater supply of licensed PTs. Physician referrals to PT for a new episode of KOA are infrequent and influenced by patient and practice factors.39:T8c6, Objective This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals. Methods A retrospective study was conducted using electronic medical records from an integrated health care system in the United States. Incident KOA visits between October 2016 and September 2017 were identified using International Classification of Diseases, Tenth Revision codes. Early PT referral was defined as a referral within 15 days of the incident KOA visit by the attending physician. Data on PT referrals, other KOA treatments, patient characteristics, physician specialty, practice location, and volume of patients with KOA were extracted. The number of licensed PTs within the county of the included practices was also obtained. We used generalized linear mixed models to predict factors associated with early PT referrals. Results Included in our study were 9,835 patients with incident KOA. Within the 12‐month period, 26% of patients had at least one PT referral (n = 2,550) and the median (interquartile range) days to the first referral was 0 (0–34) days. Early PT referral by the index physician occurred in 16.5% (n = 1,629) of patients, was less likely for patients with higher or missing knee pain scores and in rural practices, and more likely in women, patients with higher body mass index, and those seen in counties with a greater supply of licensed PTs. Conclusion Physician referrals to PT for a new episode of KOA are infrequent and influenced by patient and practice factors. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Knee Osteoarthritis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Knee Osteoarthritis (condition). Clinician-written summaries and actionable practice insights. 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RPs had validated *reductions* in circulating CD4+ and CD8+ central memory pools. scATAC-seq paradoxically showed that pro-inflammatory, migratory cell clusters were *depleted* in OA blood, while expanded populations displayed quiescent, non-migratory epigenetic signatures.","limitations":"- Discovery cohort is small (21 OA patients, 11 healthy controls), limiting statistical power for subgroup analyses.\n- scATAC-seq performed only in a patient subset, not the full cohort.\n- Cross-sectional design limits causal inference about whether immune changes drive or result from OA.","practice_takeaway":"Knee OA has a measurable and reproducible systemic immune signature — expanded Tregs and nonclassical monocytes — detectable in peripheral blood. While not yet ready for clinical use, these validated biomarkers may eventually support blood-based disease monitoring or risk stratification for progression."}},{"doi":"10.1111/dom.70892","pmid":"42219229","title":"Unveiling the\n BMI\n Risk Threshold for Osteoarthritis: Multi‐Database Causal and Nonlinear Evidence","journal_title":"Diabetes, Obesity and Metabolism","journal_issn":"1462-8902","published_at":"2026-05-31T00:00:00.000Z","url":"https://doi.org/10.1111/dom.70892","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-07T13:26:41.399Z","updated_at":"2026-06-07T13:26:41.399Z","tags":[{"paper_doi":"10.1111/dom.70892","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"category","value":"Endocrinology & Metabolism","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"condition","value":"Hip Osteoarthritis","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"condition","value":"Osteoarthritis","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"modality","value":"Weight Management","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"sample_size","value":"NHANES n≈ multiple thousand (2007–2018 cycles)","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"study_design","value":"Multi-Database Cross-Sectional and Mendelian Randomization Study","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"warning","value":"The BMI threshold of 24.00 kg/m² falls within the 'normal' range per WHO criteria for non-Asian populations but aligns with overweight thresholds used in some Asian classification systems — clinicians should consider population context when applying this threshold.","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"warning","value":"The exact NHANES sample size (total N) was not explicitly stated in the abstract or results; the sample_size tag was omitted rather than guessed.","value_numeric":null},{"paper_doi":"10.1111/dom.70892","tag_type":"warning","value":"The study design combines multiple methodologies (GBD epidemiology, NHANES observational analysis, Mendelian randomization); the level of evidence reflects the Mendelian randomization component, which approximates a Level 2 causal estimate.","value_numeric":null}],"summaries":{"what_studied":"This multi-database study examined the nonlinear relationship between BMI and osteoarthritis (OA) using Global Burden of Disease 2021 data, NHANES 2007–2018, and GWAS data, applying generalized additive models, segmented logistic regression, and Mendelian randomization to identify BMI thresholds and causal effects on knee and hip OA subtypes.","key_result":"OA risk rose nonlinearly with BMI, with breakpoints at **24.00** and **41.58 kg/m²**. Between 24.00–41.58 kg/m², each 1-unit BMI increase raised OA odds by 2.2% (OR 1.022, 95% CI 1.003–1.041); above 41.58 kg/m², by 5.5% (OR 1.055, 95% CI 1.022–1.090). Mendelian randomization confirmed causal links: BMI → knee OA (OR 1.63, 95% CI 1.50–1.77) and BMI → hip OA (OR 1.54, 95% CI 1.40–1.70). Women and adults ≥45 years showed higher knee OA susceptibility.","limitations":"- Cross-sectional NHANES data limits causal inference for the observational threshold analysis.\n- BMI does not distinguish fat mass from lean mass or fat distribution, which may affect OA risk estimates.\n- GBD and GWAS data may have geographic and ancestral heterogeneity that limits generalizability.","practice_takeaway":"Weight management counseling and OA risk screening should start when BMI exceeds **24 kg/m²** — well before the conventional overweight/obese cutoffs — especially for women and patients aged 45 or older. Clinicians should treat BMI as a modifiable, causally relevant OA risk factor, not just a correlate."}},{"doi":"10.1097/md.0000000000048913","pmid":"42216405","title":"Effect of aerobic exercise of different intensity on articular cartilage metabolism in patients with knee osteoarthritis: A randomized controlled trial","journal_title":"Medicine","journal_issn":"0025-7974","published_at":"2026-05-29T00:00:00.000Z","url":"https://doi.org/10.1097/md.0000000000048913","source_score":10,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-09T13:50:18.940Z","updated_at":"2026-06-09T13:50:18.940Z","tags":[{"paper_doi":"10.1097/md.0000000000048913","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"modality","value":"Aerobic Exercise Therapy","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"sample_size","value":"n=120","value_numeric":120},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"warning","value":"Participants self-selected exercise modality (treadmill vs. cycling), which may have introduced uncontrolled variation in joint loading between and within groups.","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"warning","value":"Primary analysis was per-protocol; ITT sensitivity analysis was performed but attrition bias cannot be fully excluded.","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"warning","value":"Short-term MRI cartilage changes (12 weeks) may partly reflect fluid/hydration shifts rather than true structural remodeling — authors acknowledge this.","value_numeric":null},{"paper_doi":"10.1097/md.0000000000048913","tag_type":"warning","value":"Trial was not prospectively registered in a clinical trial registry, which limits transparency and increases risk of outcome reporting bias.","value_numeric":null}],"summaries":{"what_studied":"This 12-week RCT compared low- (50–60% HRR), moderate- (60–70% HRR), and high-intensity (70–80% HRR) aerobic exercise (treadmill or cycling, 3×/week) vs. usual care in 120 adults aged 50–75 with Kellgren-Lawrence grade 2–3 knee OA, measuring cartilage biomarkers (CTX-II, COMP), WOMAC, VAS pain, 6MWT, and MRI cartilage morphology.","key_result":"High-intensity exercise produced the greatest improvements across all outcomes: CTX-II −28.5%, COMP −22.3%, WOMAC −45.3%, VAS pain −52.5%, cartilage thickness +4.2%, cartilage volume +3.8% (all P < .001); 80% of high-intensity participants hit the MCID for VAS pain and 73% for WOMAC; 6MWT improved by 71 m (MCID = 26 m). A significant dose–response was confirmed (group × time F(3,108) = 4.82, P = .003). No serious adverse events occurred.","limitations":"- 12-week follow-up is too short to confirm true structural cartilage remodeling (short-term MRI changes may reflect hydration shifts, not tissue change).\n- Participants chose exercise modality (treadmill vs. cycling), introducing variability in joint loading across groups.\n- Trial was not prospectively registered in a clinical trial registry, and participant/therapist blinding was not possible.","practice_takeaway":"Consider prescribing aerobic exercise at moderate-to-high intensity (60–75% HRR) for knee OA patients who can tolerate it, using wearable heart rate monitors and a progressive 4–6 week ramp-up. Even low-intensity exercise beats usual care, but higher intensities yield meaningfully greater pain relief and functional gains."}},{"doi":"10.1038/s41584-026-01389-z","pmid":"42203902","title":"Rethinking early-stage knee osteoarthritis beyond radiography","journal_title":"Nature Reviews Rheumatology","journal_issn":"1759-4790","published_at":"2026-05-27T00:00:00.000Z","url":"https://doi.org/10.1038/s41584-026-01389-z","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-30T13:22:45.110Z","updated_at":"2026-05-30T13:22:45.110Z","tags":[{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"modality","value":"Biomarker Testing","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"modality","value":"Diagnostic Imaging","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"warning","value":"Full paper text was not provided — summary is based solely on the title, journal, and DOI metadata. Key results, specific statistics, and detailed conclusions could not be verified from the source text. Treat this summary as provisional until full-text review is completed.","value_numeric":null},{"paper_doi":"10.1038/s41584-026-01389-z","tag_type":"warning","value":"The impact flag 'practice_changing' reflects the conceptual thrust of the title/framing; actual clinical impact depends on the strength of evidence synthesized within the full article.","value_numeric":null}],"summaries":{"what_studied":"This review re-examines early-stage knee osteoarthritis (OA), questioning the reliance on conventional radiography for diagnosis and staging, and exploring alternative or supplementary approaches to detect and characterize disease at earlier timepoints.","key_result":"The paper argues that radiography alone is insufficient for identifying early knee OA, and advocates for broader use of advanced imaging (e.g., MRI), biomarkers, and clinical phenotyping to capture disease at a stage when intervention may be most effective.","limitations":"As a review/opinion piece, conclusions are based on synthesized literature rather than primary data; specific sensitivity/specificity figures or head-to-head comparisons of diagnostic modalities are not independently generated by this study.","practice_takeaway":"Clinicians should not rule out early knee OA based on normal X-rays alone — consider MRI, biochemical biomarkers, and symptom-based phenotyping for earlier, more accurate diagnosis. Earlier identification may open a window for disease-modifying intervention before structural damage becomes irreversible."}},{"doi":"10.1002/acr.80066","pmid":"42007775","title":"Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study","journal_title":"Arthritis Care & Research","journal_issn":"2151-464X","published_at":"2026-05-12T00:00:00.000Z","url":"https://doi.org/10.1002/acr.80066","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-28T13:24:19.314Z","updated_at":"2026-05-28T13:24:19.314Z","tags":[{"paper_doi":"10.1002/acr.80066","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"condition","value":"Sarcopenic Obesity","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"modality","value":"Body Composition Assessment","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"modality","value":"DXA (Dual-Energy X-Ray Absorptiometry)","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"sample_size","value":"n=1211","value_numeric":1211},{"paper_doi":"10.1002/acr.80066","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"warning","value":"Mean age of 61.2 years with range not fully reported; tagged as 'older_adult' but some participants may fall in the adult range given the SD of 7.6 years.","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"warning","value":"Obesity subtypes were defined using a specific classification framework not yet universally standardized — clinicians should note that OLM/OCC definitions may differ across studies.","value_numeric":null},{"paper_doi":"10.1002/acr.80066","tag_type":"warning","value":"The 'practice_changing' impact flag reflects the novel subtyping framework and its direct implications for personalized care, but this requires validation in interventional trials before widespread clinical adoption.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated how three obesity subtypes — obesity with low muscle mass (OLM), obesity with cardiometabolic comorbidities (OCC), and uncomplicated obesity (UO) — relate to physical function at baseline and over 7 years in adults with or at risk for knee OA (MOST cohort, N=1,211, mean age 61.2 years, BMI ≥30 kg/m²).","key_result":"Compared to UO, OLM and OCC groups had worse baseline physical function and higher odds of persistent poorest-functioning trajectory over 7 years (OR 1.9 and 2.6, respectively); five distinct functional trajectories were identified, with 8% of participants in the persistently worst group.","limitations":"- Observational design limits causal inference.\n- Sample restricted to adults with or at risk for knee OA with BMI ≥30, limiting generalizability to other populations.\n- Subtype classification relies on DXA-measured body composition, which may not be universally available in clinical practice.","practice_takeaway":"When treating obese patients with knee OA, screen for low muscle mass and cardiometabolic comorbidities — these subtypes carry nearly 2–3× higher risk of sustained functional decline. Tailoring interventions (e.g., resistance training for OLM, cardiovascular risk management for OCC) may help prevent long-term mobility disability."}},{"doi":"10.1002/art.70176","pmid":"41983638","title":"Behavioral Incentives for Exercise and Intra‐Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1002/art.70176","source_score":10,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-24T13:23:05.818Z","updated_at":"2026-05-24T13:23:05.818Z","tags":[{"paper_doi":"10.1002/art.70176","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"generic","value":"glucocorticoid","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"generic","value":"lidocaine","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"modality","value":"Behavioral Intervention","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"modality","value":"Intra-Articular Corticosteroid Injection","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"sample_size","value":"n=221","value_numeric":221},{"paper_doi":"10.1002/art.70176","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"warning","value":"The crossover injection design assumes no carry-over effect; if glucocorticoids have lasting effects beyond the washout window, the crossover analysis could underestimate or mask a real benefit.","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"warning","value":"The 'practice_changing' impact flag is applied because the glucocorticoid null result, combined with a well-powered crossover confirmation, directly challenges a widely used clinical practice — but clinicians should note the VA-heavy sample.","value_numeric":null},{"paper_doi":"10.1002/art.70176","tag_type":"warning","value":"The study population was 84% male (likely US Veterans Affairs), which substantially limits generalizability to women and community-based settings.","value_numeric":null}],"summaries":{"what_studied":"A 2×2 factorial pragmatic RCT evaluated whether a behavioral incentive program (to promote physical activity) and/or intra-articular glucocorticoid injections improved symptoms (KOOS) and daily step counts over 28 weeks in 221 adults aged 40–85 with clinical knee osteoarthritis (KL grade ≥1) and an indication for joint injection.","key_result":"The incentive program increased average daily steps by 771 (P = 0.01) but did not improve KOOS scores. Glucocorticoid injections showed no benefit over lidocaine-only injections on KOOS at any time point (time-averaged β 1.72, 95% CI −1.08 to 4.52; P = 0.23), confirmed in a crossover analysis of 196 participants (β 0.36, 95% CI −1.17 to 1.90; P = 0.29). Blinding was modest: participants guessed injection order correctly only 55% of the time.","limitations":"- Sample was 84% male (US Veterans Affairs population), limiting generalizability to women and non-VA settings.\n- Step-count increase (~771/day) did not translate to symptom improvement, raising questions about whether the activity dose was sufficient or the right outcome.\n- Crossover injection design assumes no carry-over effect from the first injection, which may not hold for glucocorticoids.","practice_takeaway":"Financial or behavioral incentives can meaningfully increase physical activity in patients with knee OA, but clinicians should not expect symptom relief from the activity boost alone. Intra-articular glucocorticoids appear to offer no clinically meaningful advantage over lidocaine placebo injections for knee OA symptom relief."}},{"doi":"10.1056/nejmc2516079","pmid":"42054686","title":"Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes","journal_title":"New England Journal of Medicine","journal_issn":"0028-4793","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1056/nejmc2516079","source_score":315,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-07","doi":"10.1056/nejmc2516079","days":"7","issn":"0028-4793","rank":"9","field":"Clinical Medicine","score":"315","category":"Medicine, General & Internal","categories":["Medicine, General & Internal"],"_categories":["Medicine, General & Internal"]},"pubmed":{"doi":"10.1056/NEJMc2516079","title":"Arthroscopic Partial Meniscectomy for Degenerative Tear - 10-Year Outcomes.","journal":"The New England journal of 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Cochrane Database Syst Rev 2022;3:CD014328-CD014328.35238404","article-title":"Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears).","journal-title":"Cochrane Database Syst Rev","doi-asserted-by":null},{"DOI":"10.1056/NEJMoa1305189","key":"e_1_3_4_3_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7326/M15-0899","key":"e_1_3_4_4_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1136/annrheumdis-2017-211172","key":"e_1_3_4_5_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1136/bjsports-2020-102813","key":"e_1_3_4_6_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,4,30]]}},"alternative-id":["10.1056/NEJMc2516079"],"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["New England Journal of Medicine"],"published-print":{"date-parts":[[2026,4,30]]},"reference-count":5,"published-online":null,"references-count":5,"short-container-title":["N Engl J Med"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1056/nejmc2516079","is_oa":false,"title":"Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes","updated":"2026-05-04T08:56:22+00:00","published_date":"2026-04-29","best_oa_location":null}},"created_at":"2026-05-07T22:50:27.333Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1056/nejmc2516079","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"condition","value":"Degenerative Meniscal Tear","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"modality","value":"Arthroscopic Surgery","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"study_design","value":"Follow-Up Study","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"warning","value":"Level of evidence assigned as '2' (long-term follow-up of an RCT or controlled study) based on title context, but the precise original study design is unconfirmed from the provided metadata.","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"warning","value":"Only the paper metadata (title, DOI, journal, date) was provided — no abstract, methods, results, or full text were included. All structured content is inferred from the title alone. Numerical outcomes, sample size, study design details, comparator arms, and sex/age breakdowns could not be extracted. Clinicians should retrieve the full text before applying findings.","value_numeric":null},{"paper_doi":"10.1056/nejmc2516079","tag_type":"warning","value":"The impact_flag 'practice_changing' is tentative given this is a 10-year follow-up from the NEJM on a widely debated procedure; actual findings may confirm, refute, or nuance prior evidence.","value_numeric":null}],"summaries":{"what_studied":"This study reports 10-year outcomes of arthroscopic partial meniscectomy (APM) versus a control/sham or non-surgical comparator for degenerative meniscal tears, evaluating long-term clinical efficacy and safety.","key_result":"No specific numerical results are available from the provided source text; the study presents 10-year follow-up data on APM for degenerative meniscal tears published in the NEJM in April 2026.","limitations":"Full text and specific outcome data were not provided, limiting extraction of precise results, effect sizes, or subgroup findings.","practice_takeaway":"Clinicians managing degenerative meniscal tears should consider this 10-year follow-up data when counseling patients on the long-term value of APM versus non-operative care."}},{"doi":"10.1002/art.70154","pmid":"41878989","title":"Per‐ and Polyfluoroalkyl Substances and Knee Osteoarthritis: Data From the Osteoarthritis Initiative","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-04-24T00:00:00.000Z","url":"https://doi.org/10.1002/art.70154","source_score":5,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:49:28.843Z","updated_at":"2026-05-07T22:49:28.843Z","tags":[{"paper_doi":"10.1002/art.70154","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"generic","value":"perfluorononanoic acid","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"generic","value":"perfluorooctanoic acid","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"modality","value":"Environmental Toxin / PFAS Exposure","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"sample_size","value":"n=1,878","value_numeric":1878},{"paper_doi":"10.1002/art.70154","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"study_design","value":"Case-Cohort Study","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"warning","value":"Mean participant age of 62 years and BMI of 28.6 kg/m² may limit generalizability to younger or leaner populations.","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"warning","value":"PFOA and PFNA are legacy 'long-chain' PFAS; findings may not generalize to newer short-chain PFAS replacements now more prevalent in the environment.","value_numeric":null},{"paper_doi":"10.1002/art.70154","tag_type":"warning","value":"The study uses a case-cohort design nested within the OA Initiative; weighted logistic regression accounts for the sampling scheme, but readers should note this is not a standard cohort or RCT.","value_numeric":null}],"summaries":{"what_studied":"A case-cohort sample (n=1,878) from the Osteoarthritis Initiative examined whether serum concentrations of 8 PFAS — individually and as a mixture — were associated with incident symptomatic knee OA (KOA) and clinically meaningful knee pain progression over 48 months.","key_result":"Higher PFOA was linked to greater odds of incident symptomatic KOA (OR 1.12 per IQR, 95% CI 1.04–1.21) and knee pain progression (OR 1.10 per IQR, 95% CI 1.03–1.18). PFNA in the 3rd and 4th quartiles raised the odds of incident KOA by 63% and 55%, respectively. Mixture models confirmed PFOA and PFNA carried the strongest positive weights for both outcomes.","limitations":"Observational case-cohort design limits causal inference. PFAS were measured at a single time point, so changes in exposure over 48 months are not captured. Residual confounding by occupation, diet, or other environmental exposures cannot be excluded.","practice_takeaway":"Clinicians managing patients at risk for knee OA should be aware that higher serum PFOA and PFNA levels may modestly increase the likelihood of KOA onset and pain worsening. While not yet actionable for routine screening, this adds to growing evidence linking PFAS exposure to musculoskeletal harm."}},{"doi":"10.1002/acr.80001","pmid":"41524479","title":"Conflicts of interest reporting in trials and guidelines addressing corticosteroid injections for knee osteoarthritis.","journal_title":"Arthritis Care & Research","journal_issn":"2151-464X","published_at":"2026-01-12T00:00:00.000Z","url":"https://doi.org/10.1002/acr.80001","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1002/acr.80001","days":"7","issn":"2151-464X","rank":"9","field":"Clinical Medicine","score":"3","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":{"doi":"10.1002/acr.80001","title":"Conflicts of interest reporting in trials and guidelines addressing corticosteroid injections for knee osteoarthritis.","journal":"Arthritis care & research","methods":"","results":"Seventy-five trials and 14 guidelines were included. Twenty-nine percent of trials (n=22) and 14.3% of guidelines (n=2) had no conflict of interest statement. Ten trials (13.3%) and six guidelines (42.9%) reported a conflict of interest for at least one author. Eleven trials (14.7%) and six guidelines (42.9%) had discrepancies between disclosures in manuscripts versus reports in public databases. Forty-three trial authors (34.1%) and 19 (9.4%) guideline authors had discrepancies between disclosures in the manuscripts versus public databases.","abstract":"$30","keywords":[],"pubmed_id":"41524479","conclusions":"Conflict of interest reporting practices in trials and guidelines assessing effectiveness of corticosteroid injections for knee osteoarthritis are poor with a lack of transparency. Quality and thoroughness with reporting conflicts of interest is necessary to best understand industry influence on treatment recommendations.","publication_date":"2026-01-12T00:00:00"},"crossref":{"DOI":"10.1002/acr.80001","URL":"https://doi.org/10.1002/acr.80001","ISSN":["2151-464X","2151-4658"],"link":[{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.80001","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.80001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Conflicts of interest reporting in trials and guidelines addressing corticosteroid injections for knee osteoarthritis."],"author":[{"given":"Craig","family":"Vecchiarelli","sequence":"first","affiliation":[{"name":"Bellin College Green Bay WI"}]},{"given":"Lee","family":"Newman","sequence":"additional","affiliation":[{"name":"Bellin College Green Bay WI"}]},{"given":"Shannon T.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Bellin College Green Bay WI"}]},{"given":"Jodi L.","family":"Young","sequence":"additional","affiliation":[{"name":"Bellin College Green Bay WI"}]},{"given":"Daniel I.","family":"Rhon","sequence":"additional","affiliation":[{"name":"Uniformed Services University Bethesda MD"}]}],"issued":{"date-parts":[[2026,1,12]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2026-01-12T14:26:32Z","timestamp":1768227992000,"date-parts":[[2026,1,12]]},"indexed":{"date-time":"2026-01-12T17:46:00Z","timestamp":1768239960160,"date-parts":[[2026,1,12]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000,"date-parts":[[2026,1,12]]},"delay-in-days":0,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000,"date-parts":[[2026,1,12]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.80001"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-05"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-12-17"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-12"}],"deposited":{"date-time":"2026-01-12T14:26:32Z","timestamp":1768227992000,"date-parts":[[2026,1,12]]},"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"published":{"date-parts":[[2026,1,12]]},"publisher":"Wiley","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1002/acr.80001"],"article-number":"acr.80001","content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Arthritis Care & Research"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,12]]},"references-count":0,"short-container-title":["Arthritis Care & Research"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1002/acr.80001","is_oa":false,"title":"Conflicts of interest reporting in trials and guidelines addressing corticosteroid injections for knee osteoarthritis.","updated":"2026-01-13T16:36:47+00:00","published_date":"2026-01-12","best_oa_location":null}},"created_at":"2026-01-18T22:40:12.285Z","updated_at":"2026-01-18T22:40:12.285Z","tags":[{"paper_doi":"10.1002/acr.80001","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"modality","value":"Intra-Articular Corticosteroid","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"study_design","value":"Systematic Review","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"warning","value":"Counts refer to publications and authors, not patients.","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"warning","value":"Design is a meta-research audit using a systematic search; classifying it as a Systematic Review may be imperfect.","value_numeric":null},{"paper_doi":"10.1002/acr.80001","tag_type":"warning","value":"The abstract does not name the specific public COI databases used.","value_numeric":null}],"summaries":{"what_studied":"This study examined how conflicts of interest (COIs) are disclosed in randomized trials and clinical guidelines on corticosteroid injections for knee osteoarthritis. Searches spanned database inception to April 2025, included 75 trials and 14 guidelines, and compared manuscript disclosures against three national public COI databases.","key_result":"29% of trials (22/75) and 14.3% of guidelines (2/14) had no COI statement. COIs for at least one author were reported in 10/75 trials (13.3%) and 6/14 guidelines (42.9%). Discrepancies between manuscript disclosures and public databases occurred in 11/75 trials (14.7%) and 6/14 guidelines (42.9%), and at the author level in 43 trial authors (34.1%) and 19 guideline authors (9.4%).","practice_takeaway":"Expect inconsistent or missing COI disclosures in this literature. When appraising trials or guidelines on knee OA injections, scrutinize disclosures and, when possible, cross-check them with public COI databases."}},{"doi":"10.1002/acr.70024","pmid":"41431139","title":"The Relation of Within‐Day Physical Activity Patterns with All‐Cause Mortality in Adults with Knee Osteoarthritis: Findings from the Osteoarthritis Initiative","journal_title":"Arthritis Care & Research","journal_issn":"2151-464X","published_at":"2025-12-23T00:00:00.000Z","url":"https://doi.org/10.1002/acr.70024","source_score":14,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-12-25","doi":"10.1002/acr.70024","days":"30","issn":"2151-464X","rank":"6","field":"Clinical Medicine","score":"14","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":{"doi":"10.1002/acr.70024","title":"The Relation of Within-Day Physical Activity Patterns with All-Cause Mortality in Adults with Knee Osteoarthritis: Findings from the Osteoarthritis Initiative.","journal":"Arthritis care & research","methods":"","results":"There were 1927 adults with or at high risk for knee OA included in this analysis. We identified 4 primary within-day activity patterns accounting for ~82% of sample variability. Participants who demonstrated low levels of activity in the morning and evening had 2.09 times the risk of mortality compared to those demonstrating the average activity pattern of the sample (aHR 2.09, 95% CI [1.15, 3.80]).","abstract":"$32","keywords":[],"pubmed_id":"41431139","conclusions":"Unique within-day patterns of physical activity were associated with mortality risk. Those with inactivity in the morning and evening were at increased risk for mortality.","publication_date":"2025-12-23T00:00:00"},"crossref":{"DOI":"10.1002/acr.70024","URL":"https://doi.org/10.1002/acr.70024","ISSN":["2151-464X","2151-4658"],"link":[{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["The Relation of Within‐Day Physical Activity Patterns with All‐Cause Mortality in Adults with Knee Osteoarthritis: Findings from the Osteoarthritis Initiative"],"author":[{"given":"Sydney C.","family":"Liles","sequence":"first","affiliation":[{"name":"University of Delaware Newark DE USA"}]},{"given":"Rebecca J.","family":"Cleveland","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Chapel Hill NC USA"}]},{"given":"Jason T.","family":"Jakiela","sequence":"additional","affiliation":[{"name":"Winston‐Salem State University Winston‐Salem NC USA"}]},{"given":"Jennifer","family":"Copson","sequence":"additional","affiliation":[{"name":"University of Delaware Newark DE USA"}]},{"given":"Nurten Gizem","family":"Tore","sequence":"additional","affiliation":[{"name":"University of Delaware Newark DE USA"}]},{"given":"Yvonne M.","family":"Golightly","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Chapel Hill NC USA"},{"name":"University of Nebraska Medical Center Omaha NE USA"}]},{"given":"David M.","family":"Werner","sequence":"additional","affiliation":[{"name":"University of Dayton Dayton OH USA"}]},{"given":"Daniel K.","family":"White","sequence":"additional","affiliation":[{"name":"University of Delaware Newark DE USA"}]}],"issued":{"date-parts":[[2025,12,22]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2025-12-23T06:52:21Z","timestamp":1766472741000,"date-parts":[[2025,12,23]]},"indexed":{"date-time":"2025-12-23T06:55:16Z","timestamp":1766472916892,"date-parts":[[2025,12,23]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000,"date-parts":[[2025,12,22]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$33","language":"en","relation":{},"resource":{"primary":{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.70024"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-08-19"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-11-25"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-12-22"}],"deposited":{"date-time":"2025-12-23T06:52:22Z","timestamp":1766472742000,"date-parts":[[2025,12,23]]},"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"published":{"date-parts":[[2025,12,22]]},"publisher":"Wiley","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1002/acr.70024"],"article-number":"acr.70024","content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Arthritis Care & Research"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,12,22]]},"references-count":0,"short-container-title":["Arthritis Care & Research"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1002/acr.70024","is_oa":false,"title":"The Relation of Within‐Day Physical Activity Patterns with All‐Cause Mortality in Adults with Knee Osteoarthritis: Findings from the Osteoarthritis Initiative","updated":"2025-12-24T00:55:44+00:00","published_date":"2025-12-22","best_oa_location":null}},"created_at":"2026-01-14T18:30:49.575Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1002/acr.70024","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"condition","value":"Knee Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"sample_size","value":"n=1927","value_numeric":1927},{"paper_doi":"10.1002/acr.70024","tag_type":"study_design","value":"Cohort Study","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"warning","value":"Absolute event counts and baseline risks are not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"warning","value":"Complex analytic methods (functional principal component analysis) may limit bedside translation of pattern definitions.","value_numeric":null},{"paper_doi":"10.1002/acr.70024","tag_type":"warning","value":"Study design classification is inferred from a secondary analysis of a cohort.","value_numeric":null}],"summaries":{"what_studied":"Secondary analysis of the Osteoarthritis Initiative examined whether within-day accelerometer-derived activity patterns at baseline predicted all-cause mortality over up to 8 years in 1927 adults with or at high risk for knee osteoarthritis.","key_result":"Four daily activity patterns explained ~82% of variability; participants with low morning and evening activity had higher mortality versus the sample’s average pattern (adjusted HR 2.09, 95% CI 1.15–3.80).","limitations":"Secondary analysis of an existing cohort; the abstract provides no event counts or absolute risks.","practice_takeaway":"In adults with or at high risk for knee osteoarthritis, morning and evening inactivity on accelerometry signaled higher mortality risk; consider time-of-day activity patterns when assessing risk."}},{"doi":"10.1071/py25207","pmid":"41359807","title":"A multidisciplinary case conference model to conservatively manage hip and knee osteoarthritis: a pre-pilot feasibility and proof-of-concept study","journal_title":"Australian Journal of Primary Health","journal_issn":"1448-7527","published_at":"2025-12-08T00:00:00.000Z","url":"https://doi.org/10.1071/py25207","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1071/py25207","days":"7","issn":"1448-7527","rank":"1","field":"Clinical Medicine","score":"2","category":"Primary Health Care","categories":["Primary Health Care"],"_categories":["Primary Health Care"]},"pubmed":{"doi":"10.1071/PY25207","title":"A multidisciplinary case conference model to conservatively manage hip and knee osteoarthritis: a pre-pilot feasibility and proof-of-concept study.","journal":"Australian journal of primary health","methods":"","results":"Thematic content analysis led to the generation of four major themes from the data: (i) potential benefits; (ii) foreseeable challenges; (iii) the benefit-engagement cycle and (iv) maintenance of lifestyle changes.","abstract":"$34","keywords":["acceptability of healthcare","dietitians","exercise physiologists","exercise therapy","family practice","general practice","healthcare delivery","healthcare systems","primary healthcare","qualitative research"],"pubmed_id":"41359807","conclusions":"The proposed multidisciplinary model of care to conservatively manage hip and knee OA was perceived by both patients and clinicians to have many benefits and a limited number of manageable challenges. The identified challenges provide guidance on how the model should be refined before it is implemented in clinical practice.","publication_date":"2025-12-08T00:00:00"},"crossref":{"DOI":"10.1071/py25207","URL":"https://doi.org/10.1071/py25207","ISSN":["1448-7527","1836-7399"],"link":[{"URL":"https://connectsci.au/py/article-pdf/doi/10.1071/PY25207/1836148/py25207.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https://connectsci.au/py/article-pdf/doi/10.1071/PY25207/1836148/py25207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"6","score":1,"title":["A multidisciplinary case conference model to conservatively manage hip and knee osteoarthritis: a pre-pilot feasibility and proof-of-concept study"],"author":[{"given":"Timothy D.","family":"Miller","sequence":"first","affiliation":[{"name":"ASchool of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, Australia. 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adjusted effect sizes for predictors were not reported.","value_numeric":null},{"paper_doi":"10.1002/acr.25630","tag_type":"warning","value":"Data come from a single integrated U.S. health system; generalizability is uncertain.","value_numeric":null},{"paper_doi":"10.1002/acr.25630","tag_type":"warning","value":"Study design classification inferred from the methods description.","value_numeric":null}],"summaries":{"what_studied":"A retrospective EHR study in a U.S. integrated health system described how often and how quickly physicians referred patients with incident knee osteoarthritis to physical therapy over 12 months. It also identified factors associated with early referral (within 15 days) using generalized linear mixed models.","key_result":"Out of 9,835 patients, 26% (2,550) had at least one PT referral within 12 months; the median time to first referral was 0 days (IQR 0–34). Early referral by the index physician occurred in 16.5% (1,629), was less likely with higher or missing knee pain scores and in rural practices, and more likely in women, those with higher BMI, and in counties with more licensed PTs."}}],"initialOffset":13,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Knee Osteoarthritis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Knee Osteoarthritis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Knee Osteoarthritis"}}}]]

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