Journal of the European Academy of Dermatology and Venereology

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Some microbes commonly found in hypopigmented skin disorders, including <jats:italic>Cutibacterium acnes</jats:italic>, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.</jats:p></jats:sec>

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Lichen striatus following BCG vaccination in an infant

Indian Pediatr

Lichen striatus (LS) is an acquired skin disorder with a linear pattern along Blaschko's lines. It commonly occurs in childhood, and the lesions spontaneously regress within several months.
Although up to 50% of LS cases exhibit hypopigmentation that can persist for several months to years, it is unknown why LS is associated with such a high incidence of hypopigmentation compared to other inflammatory skin diseases. Therefore, this study aimed to analyse the differences in the skin microbiome between LS patients with and without hypopigmentation.
Differences in skin microbiome were analysed using whole genome sequencing of skin biopsies and subsequent bioinformatics analyses.
Some microbes commonly found in hypopigmented skin disorders, including Cutibacterium acnes, were more abundant in patients with LS showing hypopigmentation than in those not showing hypopigmentation.
The skin microbiota may be involved in the development of hypopigmentation in LS and may be considered a treatment target to reduce LS duration and hypopigmentation.

Lichen Striatus: Research & Clinical Takeaways

Association between the skin microbiome and lichen striatus hypopigmentation: <i>Cutibacterium acnes</i> as a potential cause

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