2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T61d,Cryolipolysis is an effective, well-tolerated noninvasive subcutaneous fat reduction treatment. Assess participant satisfaction, effectiveness, and safety of a dual-applicator cryolipolysis system that can deliver simultaneous treatments. Adult participants received treatment to the abdomen/flanks (midsection). Participants could also receive treatment to upper arms, thighs, and submental area. Primary end point was participant satisfaction with midsection results at 12 weeks after final treatment. Secondary end points included independent photography review, participant satisfaction with additional body areas, and overall satisfaction. Exploratory end points included 3D imaging of midsection volumetric changes and assessments at 4 weeks after initial treatment. Safety was monitored throughout. Of 110 treated participants, 75% were female. Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were "satisfied/very satisfied" with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects. The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety.31:T8b6, BACKGROUND Cryolipolysis is an effective, well-tolerated noninvasive subcutaneous fat reduction treatment. OBJECTIVE Assess participant satisfaction, effectiveness, and safety of a dual-applicator cryolipolysis system that can deliver simultaneous treatments. MATERIALS AND METHODS Adult participants received treatment to the abdomen/flanks (midsection). Participants could also receive treatment to upper arms, thighs, and submental area. Primary end point was participant satisfaction with midsection results at 12 weeks after final treatment. Secondary end points included independent photography review, participant satisfaction with additional body areas, and overall satisfaction. Exploratory end points included 3D imaging of midsection volumetric changes and assessments at 4 weeks after initial treatment. Safety was monitored throughout. RESULTS Of 110 treated participants, 75% were female. Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were “satisfied/very satisfied” with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects. CONCLUSION The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Localized Adiposity: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Localized Adiposity (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Localized%20Adiposity\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Localized Adiposity\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Localized%20Adiposity\"}]}}"}}]],["$","$L2f",null,{"title":"Localized Adiposity: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Localized Adiposity with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1097/dss.0000000000004797","pmid":"40929520","title":"Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study","journal_title":"Dermatologic Surgery","journal_issn":"1076-0512","published_at":"2025-09-10T00:00:00.000Z","url":"https://doi.org/10.1097/dss.0000000000004797","source_score":70,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-09-13","doi":"10.1097/dss.0000000000004797","days":"30","issn":"1076-0512","rank":"8","field":"Clinical Medicine","score":"70","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1097/DSS.0000000000004797","title":"Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study.","journal":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","methods":"","results":"Of 110 treated participants, 75% were female. Mean age and body mass index were 43 years and 25.1 kg/m2, respectively. Of 96 evaluable participants, 83.3% (80/96) were \"satisfied/very satisfied\" with midsection results. Reviewers correctly identified 88.0% (81/92) of baseline versus 12 weeks after final treatment midsection images. Mean (SD) subcutaneous fat volume loss was 194.8 (492.3) mL at 12 weeks after final treatment (p < .001). Visible improvements were noted at 4 weeks after initial treatment by a majority of physician reviewers and participants. Five (4.5%, 5/110) participants reported 7 treatment-emergent adverse device effects.","abstract":"$30","keywords":[],"pubmed_id":"40929520","conclusions":"The dual-applicator cryolipolysis system demonstrated high participant satisfaction, effectiveness, and safety.","publication_date":"2025-09-10T00:00:00"},"crossref":{"DOI":"10.1097/dss.0000000000004797","URL":"https://doi.org/10.1097/dss.0000000000004797","ISSN":["1076-0512","1524-4725"],"link":[{"URL":"https://journals.lww.com/10.1097/DSS.0000000000004797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study"],"author":[{"given":"Roy G.","family":"Geronemus","sequence":"first","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York, New York;"}]},{"given":"Jordan V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York, New York;"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A Platinum Dermatology Partners Company, San Diego, California;"}]},{"given":"Sabrina","family":"Fabi","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A Platinum Dermatology Partners Company, San Diego, California;"}]},{"given":"Suzanne","family":"Kilmer","sequence":"additional","affiliation":[{"name":"The Laser & Skin Surgery Medical Group, Inc., Sacramento, California;"}]},{"given":"Jens","family":"Altmann","sequence":"additional","affiliation":[{"name":"BodenseeKLINIK, Lindau, Germany;"}]},{"given":"Jean M.","family":"Mazer","sequence":"additional","affiliation":[{"name":"Centre Laser International de la Peau, Paris, France;"}]},{"given":"Ulf","family":"Samuelson","sequence":"additional","affiliation":[{"name":"Akademikliniken, Stockholm, Sweden;"}]},{"given":"Terence","family":"Tan","sequence":"additional","affiliation":[{"name":"Halley Body Slimming Clinic, Singapore;"}]},{"given":"Maria","family":"Ali","sequence":"additional","affiliation":[{"name":"Peloton Advantage, LLC (an OPEN Health Company), Parsippany, New Jersey;"}]},{"given":"Meetu","family":"Bhogal","sequence":"additional","affiliation":[{"name":"AbbVie, Toronto, Ontario, Canada; and"}]},{"given":"Vaishali","family":"Patel","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]},{"given":"Hongyan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]},{"given":"Alda","family":"Karic","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company, Irvine, California."}]}],"issued":{"date-parts":[[2025,9,10]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":null,"created":{"date-time":"2025-09-10T19:01:46Z","timestamp":1757530906000,"date-parts":[[2025,9,10]]},"indexed":{"date-time":"2025-09-11T22:44:40Z","timestamp":1757630680603,"date-parts":[[2025,9,11]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","start":{"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000,"date-parts":[[2025,9,10]]},"delay-in-days":0,"content-version":"unspecified"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/DSS.0000000000004797"}},"subtitle":[],"deposited":{"date-time":"2025-09-10T19:01:48Z","timestamp":1757530908000,"date-parts":[[2025,9,10]]},"issn-type":[{"type":"print","value":"1076-0512"},{"type":"electronic","value":"1524-4725"}],"published":{"date-parts":[[2025,9,10]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":[{"DOI":"10.1097/01.DSS.0000452628.99209.4f","key":"R4-20250910","year":"2014","issue":null,"author":"Boey","volume":"40","first-page":"1004","unstructured":null,"article-title":"Fat reduction in the inner thigh using a prototype cryolipolysis applicator","journal-title":"Dermatol Surg","doi-asserted-by":"crossref"},{"DOI":"10.1002/lsm.22302","key":"R5-20250910","year":"2014","issue":null,"author":"Bernstein","volume":"46","first-page":"731","unstructured":null,"article-title":"Non-invasive fat reduction of the flanks using a new cryolipolysis applicator and overlapping, two-cycle treatments","journal-title":"Lasers Surg Med","doi-asserted-by":"crossref"},{"DOI":"10.1002/lsm.22207","key":"R6-20250910","year":"2014","issue":null,"author":"Garibyan","volume":"46","first-page":"75","unstructured":null,"article-title":"Three-dimensional volumetric quantification of fat loss following cryolipolysis","journal-title":"Lasers Surg Med","doi-asserted-by":"crossref"},{"DOI":"10.1002/lsm.22440","key":"R7-20250910","year":"2016","issue":null,"author":"Kilmer","volume":"48","first-page":"3","unstructured":null,"article-title":"Safety and efficacy of cryolipolysis for non-invasive reduction of submental fat","journal-title":"Lasers Surg Med","doi-asserted-by":"crossref"},{"DOI":"10.1097/DSS.0000000000001802","key":"R8-20250910","year":"2019","issue":null,"author":"Friedmann","volume":"45","first-page":"1185","unstructured":null,"article-title":"Cryolipolysis for noninvasive contouring of the periumbilical abdomen with a nonvacuum conformable-surface applicator","journal-title":"Dermatol Surg","doi-asserted-by":"crossref"},{"DOI":"10.1111/dth.14850","key":"R9-20250910","year":"2021","issue":null,"author":"McKeown","volume":"34","first-page":"e14850","unstructured":null,"article-title":"Significant improvement in body contour with multiple cycles of CoolSculpting: results of a prospective study","journal-title":"Dermatol Ther","doi-asserted-by":"crossref"},{"DOI":"10.1093/asj/sjab421","key":"R10-20250910","year":"2022","issue":null,"author":"Tan","volume":"42","first-page":"760","unstructured":null,"article-title":"High participant satisfaction achieved using cryolipolysis for fat reduction of the abdomen and flanks","journal-title":"Aesthet Surg J","doi-asserted-by":"crossref"},{"DOI":"10.1093/asjof/ojac067","key":"R11-20250910","year":"2022","issue":null,"author":"Altmann","volume":"4","first-page":"ojac067","unstructured":null,"article-title":"Patient satisfaction, recommendation rate, and patient comfort with an FDA-cleared cryolipolysis system","journal-title":"Aesthet Surg J Open Forum","doi-asserted-by":"crossref"},{"DOI":"10.1093/asjof/ojac008","key":"R13-20250910","year":"2022","issue":null,"author":"Altmann","volume":"4","first-page":"ojac008","unstructured":null,"article-title":"Global expert opinion on cryolipolysis treatment recommendations and considerations: a modified Delphi study","journal-title":"Aesthet Surg J Open Forum","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1097/lww.0000000000001000","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Dermatologic Surgery"],"reference-count":9,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,9,10]]},"references-count":9,"short-container-title":["Dermatol Surg","DS"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1097/dss.0000000000004797","is_oa":true,"title":"Participant Satisfaction, Effectiveness, and Safety With a Novel Dual-Applicator Cryolipolysis System: A Prospective, Multicountry Study","updated":"2025-09-14T03:39:29+00:00","published_date":"2025-09-10","best_oa_location":{"url":"https://doi.org/10.1097/dss.0000000000004797","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1097/dss.0000000000004797"}}},"created_at":"2025-09-30T13:03:24.817Z","updated_at":"2025-10-13T07:32:37.233Z","tags":[{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"brand","value":"CoolSculpting Elite","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"condition","value":"Localized Adiposity","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"generic","value":"cryolipolysis","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"modality","value":"Cryolipolysis","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"sample_size","value":"n=110","value_numeric":110},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"warning","value":"Design classification is approximate; this was a single‑arm, open‑label, postmarketing device evaluation without a control group.","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"warning","value":"Several outcomes (e.g., 3D volumetrics) were assessed in subsets, and numbers were small for non‑midsection areas.","value_numeric":null},{"paper_doi":"10.1097/dss.0000000000004797","tag_type":"warning","value":"Some sections of the article text were truncated in the source view; summary relies on reported data and figures provided.","value_numeric":null}],"summaries":{"what_studied":"A prospective, multicountry, open-label postmarketing study evaluated a dual‑applicator cryolipolysis system (CoolSculpting Elite) in adults treated to the midsection (abdomen/flanks), with optional treatment to upper arms, thighs, and submental area; the primary end point was midsection satisfaction at 12 weeks after final treatment.","key_result":"At 12 weeks after the final session, 83.3% (80/96) of evaluable participants reported being satisfied/very satisfied with midsection results.","limitations":"Single‑arm, nonrandomized design without a control group; 3D volumetric assessments had large variability and potential positioning/clothing effects; free treatment and small samples for non‑midsection areas may bias satisfaction and limit generalizability.","practice_takeaway":"For adults seeking noninvasive midsection fat reduction, dual‑applicator cryolipolysis achieved high satisfaction at 12 weeks, with device‑related adverse effects in 4.5% (5/110), all mild and resolved. Findings are consistent with prior cryolipolysis studies."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Localized Adiposity"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Localized Adiposity"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Localized Adiposity"}}}]]

Papers