30:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 2f:T417,{"@context":"https://schema.org","@type":"CollectionPage","name":"Metabolic Dysfunction–Associated Steatotic Liver Disease: condition Research & Clinical Takeaways","description":"Explore peer-reviewed papers on Metabolic Dysfunction–Associated Steatotic Liver Disease (condition). Clinician-written summaries and actionable practice insights. Updated daily.","url":"https://www.reachrx.ai/hub/tag/condition/Metabolic%20Dysfunction%E2%80%93Associated%20Steatotic%20Liver%20Disease","breadcrumb":{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.reachrx.ai"},{"@type":"ListItem","position":2,"name":"Research Hub","item":"https://www.reachrx.ai/hub"},{"@type":"ListItem","position":3,"name":"Conditions","item":"https://www.reachrx.ai/hub/tag/condition"},{"@type":"ListItem","position":4,"name":"Metabolic Dysfunction–Associated Steatotic Liver Disease","item":"https://www.reachrx.ai/hub/tag/condition/Metabolic%20Dysfunction%E2%80%93Associated%20Steatotic%20Liver%20Disease"}]}}31:T66a,Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease, yet known biological risk factors do not fully explain its development. This study evaluated the association between social determinants of health (SDH)-including income, education, housing, and environmental factors-and MASLD in children with overweight or obesity. This cross-sectional study included children with overweight or obesity evaluated in pediatric gastroenterology clinics, stratified by the presence of MASLD. Participants' residential census tracts were linked to the California Healthy Places Index (HPI), where higher scores indicate greater socioeconomic advantage. Generalized linear regression models, adjusted for age, sex, race, ethnicity, and body mass index (BMI), assessed associations between SDH and MASLD. The study included 888 children (mean age: 12.8±2.9 y, mean BMI: 30.6±6.4 kg/m2). Children with MASLD lived in neighborhoods with significantly lower HPI scores than those without MASLD (-0.22 vs. -0.03; 41st vs. 49th percentile, p=0.01). They also resided in areas with significantly lower socioeconomic advantage across multiple HPI subdomains, including housing (-0.16 vs. 0.03; 44th vs. 51st percentile, p<0.001) and economic (-0.38 vs. -0.12; 36th vs. 55th percentile, p<0.001) scores. Children with MASLD were more likely to live in neighborhoods with greater socioeconomic and environmental disadvantage than their peers with overweight or obesity but without MASLD. These findings highlight potential SDH targets for public health interventions aimed at reducing MASLD risk in children.32:Ta3d, Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common pediatric liver disease, yet known biological risk factors do not fully explain its development. This study evaluated the association between social determinants of health (SDH)—including income, education, housing, and environmental factors—and MASLD in children with overweight or obesity. Methods: This cross-sectional study included children with overweight or obesity evaluated in pediatric gastroenterology clinics, stratified by the presence of MASLD. Participants’ residential census tracts were linked to the California Healthy Places Index (HPI), where higher scores indicate greater socioeconomic advantage. Generalized linear regression models, adjusted for age, sex, race, ethnicity, and body mass index (BMI), assessed associations between SDH and MASLD. Results: The study included 888 children (mean age: 12.8±2.9 y, mean BMI: 30.6±6.4 kg/m 2 ). Children with MASLD lived in neighborhoods with significantly lower HPI scores than those without MASLD (−0.22 vs. −0.03; 41st vs. 49th percentile, p =0.01). They also resided in areas with significantly lower socioeconomic advantage across multiple HPI subdomains, including housing (−0.16 vs. 0.03; 44th vs. 51st percentile, p <0.001) and economic (−0.38 vs. −0.12; 36th vs. 55th percentile, p <0.001) scores. Conclusions: Children with MASLD were more likely to live in neighborhoods with greater socioeconomic and environmental disadvantage than their peers with overweight or obesity but without MASLD. These findings highlight potential SDH targets for public health interventions aimed at reducing MASLD risk in children. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$2f"}}]],["$","$L30",null,{"title":"Metabolic Dysfunction–Associated Steatotic Liver Disease: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Metabolic Dysfunction–Associated Steatotic Liver Disease with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1097/hc9.0000000000000857","pmid":"41264907","title":"Neighborhood disparities and metabolic dysfunction–associated steatotic liver disease in children with overweight or obesity","journal_title":"Hepatology Communications","journal_issn":"2471-254X","published_at":"2025-11-20T00:00:00.000Z","url":"https://doi.org/10.1097/hc9.0000000000000857","source_score":15,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-22","doi":"10.1097/hc9.0000000000000857","days":"14","issn":"2471-254X","rank":"10","field":"Clinical Medicine","score":"15","category":"Gastroenterology & Hepatology","categories":["Gastroenterology & Hepatology"],"_categories":["Gastroenterology & Hepatology"]},"pubmed":{"doi":"10.1097/HC9.0000000000000857","title":"Neighborhood disparities and metabolic dysfunction-associated steatotic liver disease in children with overweight or obesity.","journal":"Hepatology communications","methods":"","results":"The study included 888 children (mean age: 12.8±2.9 y, mean BMI: 30.6±6.4 kg/m2). Children with MASLD lived in neighborhoods with significantly lower HPI scores than those without MASLD (-0.22 vs. -0.03; 41st vs. 49th percentile, p=0.01). They also resided in areas with significantly lower socioeconomic advantage across multiple HPI subdomains, including housing (-0.16 vs. 0.03; 44th vs. 51st percentile, p<0.001) and economic (-0.38 vs. -0.12; 36th vs. 55th percentile, p<0.001) scores.","abstract":"$31","keywords":["environmental risk factors","pediatrics","social determinants of health","socioeconomic barriers","steatohepatitis"],"pubmed_id":"41264907","conclusions":"","publication_date":"2025-11-20T00:00:00"},"crossref":{"DOI":"10.1097/hc9.0000000000000857","URL":"https://doi.org/10.1097/hc9.0000000000000857","ISSN":["2471-254X"],"link":[{"URL":"https://journals.lww.com/10.1097/HC9.0000000000000857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"12","score":1,"title":["Neighborhood disparities and metabolic dysfunction–associated steatotic liver disease in children with overweight or 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Disease","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"sample_size","value":"n=888","value_numeric":888},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"warning","value":"Adjusted regression is mentioned, but adjusted effect estimates are not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"warning","value":"MASLD diagnostic criteria are not described in the abstract.","value_numeric":null},{"paper_doi":"10.1097/hc9.0000000000000857","tag_type":"warning","value":"Use of the California Healthy Places Index may limit applicability outside California; generalizability is not specified.","value_numeric":null}],"summaries":{"what_studied":"Cross-sectional study of 888 children with overweight or obesity seen in pediatric gastroenterology clinics, examining links between neighborhood social determinants of health (California Healthy Places Index, HPI) and MASLD using adjusted generalized linear models.","key_result":"Children with MASLD lived in neighborhoods with lower overall HPI scores than those without MASLD (-0.22 vs -0.03; 41st vs 49th percentile; p=0.01), with lower housing (-0.16 vs 0.03; 44th vs 51st percentile; p<0.001) and economic (-0.38 vs -0.12; 36th vs 55th percentile; p<0.001) subdomain scores.","limitations":"Cross-sectional design; clinic-based sample from pediatric gastroenterology clinics; neighborhood-level SDH measured via census tract HPI rather than individual-level measures.","practice_takeaway":"Among children with overweight or obesity, MASLD is associated with greater neighborhood socioeconomic disadvantage on the HPI. Clinicians should consider SDH context when assessing MASLD risk and partnering with public health efforts targeting housing and economic disadvantage."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Metabolic Dysfunction–Associated Steatotic Liver Disease"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Metabolic Dysfunction–Associated Steatotic Liver Disease"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Metabolic Dysfunction–Associated Steatotic Liver Disease"}}}]]

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