2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T898,This research article aims to describe the prevalence, associations, and health-related quality of life (HRQoL) impact of mucocutaneous features of systemic lupus erythematosus (SLE). Data from the Asia-Pacific Lupus Collaboration cohort were analyzed (2013-2021). Mucocutaneous activity (MC-A) items were rash, alopecia, and mucosal ulcers; were defined by the Systemic Lupus Erythematosus Disease Activity Index 2000; and were persistent if present for at least six months. Mucocutaneous damage (MC-D) items were chronic skin ulceration, scarring alopecia, and skin/panniculum scarring and were defined by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. HRQoL was measured by 36-Item Short Form Health Survey (SF-36) surveys. Multivariate logistic generalized estimating equation models were used to determine correlates of MC-A at each visit. Time-varying covariate survival models were used to determine predictors of MC-D. During a median of 2.5 (interquartile range 1.0-5.1) years' follow-up, 1,499 of 4,102 patients (36.5%) had MC-A (rash n = 1,055, alopecia n = 731, mucosal ulcers n = 352) and 606 of 3,655 patients (16.6%) had persistent MC-A. These patients were more likely to record worse mean mental (42.6 vs 44.8; P = 0.014) and physical component (41.1 vs 46.1; P < 0.001) SF-36 scores. Being White, smoking, serologic activity, vasculitis, myositis, serositis, nephritis, and neurologic/psychiatric features were correlates of MC-A. Of 3,647 patients, 157 (4.3%) accrued MC-D (skin/panniculum scarring n = 53, alopecia n = 98, ulceration n = 30). These patients had worse mean physical component (39.8 vs 46.0, P = 0.001) SF-36 scores and were more likely to be White with persistent MC-A. All mucocutaneous manifestations were associated with worse HRQoL. MC-A correlated with serologic and systemic disease activity burden in SLE. Persistent MC-A was associated with increased risk of MC-D, emphasizing the importance of early and effective treatment. Both MC-A and MC-D were more likely in White patients, suggesting ethnic and environmental impacts. Smoking was a potentially modifiable correlate of MC-A.31:Tc1a, Objective This research article aims to describe the prevalence, associations, and health‐related quality of life (HRQoL) impact of mucocutaneous features of systemic lupus erythematosus (SLE). Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analyzed (2013–2021). Mucocutaneous activity (MC‐A) items were rash, alopecia, and mucosal ulcers; were defined by the Systemic Lupus Erythematosus Disease Activity Index 2000; and were persistent if present for at least six months. Mucocutaneous damage (MC‐D) items were chronic skin ulceration, scarring alopecia, and skin/panniculum scarring and were defined by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. HRQoL was measured by 36‐Item Short Form Health Survey (SF‐36) surveys. Multivariate logistic generalized estimating equation models were used to determine correlates of MC‐A at each visit. Time‐varying covariate survival models were used to determine predictors of MC‐D. Results During a median of 2.5 (interquartile range 1.0–5.1) years’ follow‐up, 1,499 of 4,102 patients (36.5%) had MC‐A (rash n = 1,055, alopecia n = 731, mucosal ulcers n = 352) and 606 of 3,655 patients (16.6%) had persistent MC‐A. These patients were more likely to record worse mean mental (42.6 vs 44.8; P = 0.014) and physical component (41.1 vs 46.1; P < 0.001) SF‐36 scores. Being White, smoking, serologic activity, vasculitis, myositis, serositis, nephritis, and neurologic/psychiatric features were correlates of MC‐A. Of 3,647 patients, 157 (4.3%) accrued MC‐D (skin/panniculum scarring n = 53, alopecia n = 98, ulceration n = 30). These patients had worse mean physical component (39.8 vs 46.0, P = 0.001) SF‐36 scores and were more likely to be White with persistent MC‐A. Conclusion All mucocutaneous manifestations were associated with worse HRQoL. MC‐A correlated with serologic and systemic disease activity burden in SLE. Persistent MC‐A was associated with increased risk of MC‐D, emphasizing the importance of early and effective treatment. Both MC‐A and MC‐D were more likely in White patients, suggesting ethnic and environmental impacts. Smoking was a potentially modifiable correlate of MC‐A. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Mucocutaneous Lupus: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Mucocutaneous Lupus (condition). Clinician-written summaries and actionable practice insights. 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These patients were more likely to record worse mean mental (42.6 vs 44.8; P = 0.014) and physical component (41.1 vs 46.1; P < 0.001) SF-36 scores. Being White, smoking, serologic activity, vasculitis, myositis, serositis, nephritis, and neurologic/psychiatric features were correlates of MC-A. Of 3,647 patients, 157 (4.3%) accrued MC-D (skin/panniculum scarring n = 53, alopecia n = 98, ulceration n = 30). These patients had worse mean physical component (39.8 vs 46.0, P = 0.001) SF-36 scores and were more likely to be White with persistent MC-A.","abstract":"$30","keywords":[],"pubmed_id":"41940438","conclusions":"All mucocutaneous manifestations were associated with worse HRQoL. MC-A correlated with serologic and systemic disease activity burden in SLE. Persistent MC-A was associated with increased risk of MC-D, emphasizing the importance of early and effective treatment. Both MC-A and MC-D were more likely in White patients, suggesting ethnic and environmental impacts. Smoking was a potentially modifiable correlate of MC-A.","publication_date":"2026-04-06T00:00:00"},"crossref":{"DOI":"10.1002/acr.80050","URL":"https://doi.org/10.1002/acr.80050","ISSN":["2151-464X","2151-4658"],"link":[{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.80050","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/full-xml/10.1002/acr.80050","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.80050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia‐Pacific Lupus Collaboration Longitudinal Cohort 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Lupus","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"condition","value":"Systemic Lupus Erythematosus","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"modality","value":"Disease Activity Monitoring","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"sample_size","value":"n=4102","value_numeric":4102},{"paper_doi":"10.1002/acr.80050","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"warning","value":"No specific treatments or therapeutic interventions were evaluated — the modality tag reflects disease monitoring rather than a drug intervention.","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"warning","value":"The study is observational; associations (e.g., smoking with MC-A) do not confirm causation.","value_numeric":null},{"paper_doi":"10.1002/acr.80050","tag_type":"warning","value":"White patients were a minority within this Asia-Pacific cohort; findings of higher MC-A and MC-D rates in White patients should be interpreted cautiously given potential for small-subgroup effects.","value_numeric":null}],"summaries":{"what_studied":"Prevalence, correlates, and HRQoL impact of mucocutaneous disease activity (MC-A: rash, alopecia, mucosal ulcers) and damage (MC-D: scarring alopecia, skin/panniculum scarring, chronic ulceration) in 4,102 SLE patients from the Asia-Pacific Lupus Collaboration cohort, followed for a median of 2.5 years (2013–2021).","key_result":"36.5% of patients had MC-A and 16.6% had persistent MC-A (≥6 months); both were linked to significantly worse SF-36 physical scores (41.1 vs 46.1, P<0.001). MC-D accrued in 4.3% of patients and was predicted by White ethnicity and persistent MC-A. Smoking was an independently modifiable correlate of MC-A.","limitations":"Cohort is Asia-Pacific based, which may limit generalizability to other regions; White patients were a minority, so ethnic comparisons may be underpowered; HRQoL was measured by SF-36, which is not lupus-specific.","practice_takeaway":"Persistent mucocutaneous activity in SLE drives both reduced quality of life and long-term skin damage — early, effective treatment to suppress MC-A is key to preventing damage accrual. Counsel patients to stop smoking, as it is a modifiable risk factor for mucocutaneous flares."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Mucocutaneous Lupus"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Mucocutaneous Lupus"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Mucocutaneous Lupus"}}}]]

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