2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T644,To emphasize the diagnostic value of cutaneous manifestations in disseminated invasive fungal disease (IFD). IFD carry high mortality and diagnosis is often delayed, while early recognition is crucial for patient outcomes. This review focuses on skin manifestations of fungi of highest relevance according to the WHO: Candida spp., Aspergillus spp., Mucorales, Fusarium spp., and Scedosporium spp. Cutaneous signs in disseminated candidiasis typically manifest as maculopapular or nodular lesions. Frequency and morphology vary depending on the Candida spp. involved. Secondary cutaneous aspergillosis presents with variable morphologies, including erythematous papules, ulcerative nodules, hemorrhagic bullae, or necrotic eschars, and may appear before standard diagnostic tests yield positive results. In invasive fusariosis, lesions typically present as vesicles or papules and progress to necrotic eschars. The morphology of skin manifestations of generalized mucormycosis varies according to the underlying disease. The formation of a necrotic eschar is considered pathognomonic. In disseminated scedosporiosis, cutaneous manifestations include ecchymoses, hemorrhagic bullae, necrotic papules, ulcers, or infiltrative plaques, often resembling infections with aspergillosis or fusariosis. Diagnosis requires a multimodal approach combining histopathology, microbiological cultures and nonculture-based assays. Despite the variability in frequency and presentation, cutaneous manifestations provide a valuable clinical clue in disseminated IFD and may facilitate early recognition and intervention.31:T9ff, Purpose of review To emphasize the diagnostic value of cutaneous manifestations in disseminated invasive fungal disease (IFD). IFD carry high mortality and diagnosis is often delayed, while early recognition is crucial for patient outcomes. This review focuses on skin manifestations of fungi of highest relevance according to the WHO: Candida spp., Aspergillus spp., Mucorales, Fusarium spp., and Scedosporium spp. Recent findings Cutaneous signs in disseminated candidiasis typically manifest as maculopapular or nodular lesions. Frequency and morphology vary depending on the Candida spp. involved. Secondary cutaneous aspergillosis presents with variable morphologies, including erythematous papules, ulcerative nodules, hemorrhagic bullae, or necrotic eschars, and may appear before standard diagnostic tests yield positive results. In invasive fusariosis, lesions typically present as vesicles or papules and progress to necrotic eschars. The morphology of skin manifestations of generalized mucormycosis varies according to the underlying disease. The formation of a necrotic eschar is considered pathognomonic. In disseminated scedosporiosis, cutaneous manifestations include ecchymoses, hemorrhagic bullae, necrotic papules, ulcers, or infiltrative plaques, often resembling infections with aspergillosis or fusariosis. Diagnosis requires a multimodal approach combining histopathology, microbiological cultures and nonculture-based assays. Summary Despite the variability in frequency and presentation, cutaneous manifestations provide a valuable clinical clue in disseminated IFD and may facilitate early recognition and intervention. 32:T993,Abstract Background Mucormycosis is a severe fungal infection that is challenging to diagnose as traditional methods lack sensitivity and serological testing is unavailable. This study aimed to evaluate the MucorGenius® PCR assay on respiratory and biopsy samples from high-risk patients with probable/proven invasive pulmonary aspergillosis (IPA), mucormycosis, or possible invasive mold infections (IMIs). Methods This multicenter cohort study was conducted across 4 sites in Austria, Belgium and the UK. A total of 132 respiratory and biopsy samples from 114 patients with IMI diagnosed in clinical routine (10 proven IPA, 13 proven mucormycosis, 62 probable IPA, 5 probable mucormycosis, and 35 possible IMI according to EORTC/MSGERC 2020 and FUNDICU criteria; 11 IPA/mucormycosis coinfections) were analyzed using the MucorGenius® PCR assay in ISO-certified laboratories. Results were compared with standard fungal diagnostics. Results Mucorales DNA was detected in 37/132 samples (28%) including 29 BAL fluids, 1 bronchial aspirate, 1 endotracheal aspirate, and 6 biopsies from 37 patients. Sensitivity was 94.4% (17/18) for detecting probable/proven mucormycosis (including 11 cases routinely diagnosed with IPA/mucormycosis coinfection). Among 72 patients with probable/proven IPA, 21 (29.2%) tested positive for Mucorales DNA, including 11 missed by routine diagnostics. Mucorales DNA was also detected in 9/35 (25.7%) of patients with possible IMI. Conclusions MucorGenius® PCR showed high sensitivity for detecting Mucorales and may support improved diagnosis of probable mucormycosis when included as a mycological criterion. It appears particularly valuable for identifying Aspergillus-Mucorales coinfections and detecting mucormycosis in patients with host factors, clinical or radiological evidence of IMI when routine diagnostics are negative. 33:T845,The fungal diagnostic landscape is evolving; whereas previously, traditional culture-based methods dominated, most invasive fungal disease is now diagnosed with non-culture-based tests, including direct microscopy, antigen, antibody, and molecular assays, supported by histopathology and radiology. Access to and turnaround time of diagnostic tests and their clinical implementation varies across the UK. The British Society for Medical Mycology convened an expert group to update its 2015 best practice guidance. Guidance on histopathology and radiology investigations remain unchanged from the 2015 standards of care. For each mycological test, we include test-specific commentaries and accompanying tables, with expected turnaround times (sample collection to reporting). Based on recent evidence, new or stronger recommendations include use of Pneumocystis PCR; 1,3-β-D-glucan testing for suspected invasive candidiasis and Pneumocystis pneumonia; higher volume respiratory sample cultures; Aspergillus antigen or antibody-based testing in expanded clinically vulnerable populations, including patients in intensive care units and patients with chronic respiratory disease (including asthma); use of Candida PCR and Mucorales PCR in specific contexts; pan-fungal PCR and DNA sequencing for fungal identification from positive microscopy or histopathology specimens; and inclusion of posaconazole and isavuconazole in therapeutic antifungal monitoring recommendations. We discuss integration of diagnostic tests with antifungal stewardship and common clinical scenarios. Although recommendations focus on adults and UK practice, use in paediatric populations and worldwide applicability is discussed. Recommendations are presented as auditable standards to facilitate implementation and quality improvement measures. An emphasis on integration of combined diagnostics with antifungal stewardship and clinical pathways extends guideline relevance beyond microbiology laboratories to clinicians investigating patients with multimorbidity and suspected fungal disease within increasingly complex health-care systems.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Mucormycosis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Mucormycosis (condition). Clinician-written summaries and actionable practice insights. 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Pair targeted non-culture-based diagnostics with prompt antifungal therapy rather than waiting for culture confirmation."}},{"doi":"10.1016/j.ijmmb.2026.101128","pmid":"42069084","title":"Indian Fungal Infection National Declaration (I-Find)","journal_title":"Indian Journal of Medical Microbiology","journal_issn":"0255-0857","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.ijmmb.2026.101128","source_score":22,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-21T13:20:58.302Z","updated_at":"2026-05-21T13:20:58.302Z","tags":[{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"category","value":"Immunology","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Aspergillosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Candidiasis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Dermatophytosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Fungal Keratitis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Invasive Fungal Disease","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Mucormycosis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"condition","value":"Vulvovaginal Candidiasis","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"generic","value":"azole antifungals","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"modality","value":"Antifungal Stewardship","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"study_design","value":"Consensus Statement / Policy Declaration","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"Study design label 'Consensus Statement / Policy Declaration' is not a standard RCT/cohort design; clinicians should interpret recommendations as expert-level guidance pending formal empirical validation.","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"The 4.1% population burden estimate and ~50% invasive fungal disease mortality figures are cited from prior literature; the declaration does not independently validate these numbers.","value_numeric":null},{"paper_doi":"10.1016/j.ijmmb.2026.101128","tag_type":"warning","value":"This paper is a policy/consensus declaration, not an interventional or observational study — no primary data are presented. Level of evidence is set at 7 (expert opinion/consensus).","value_numeric":null}],"summaries":{"what_studied":"The Indian Fungal Infection National Declaration (I-FIND) evaluates the burden of serious fungal diseases in India — estimated to affect 4.1% of the population — and proposes a structured, time-bound national response across 9 core domains to reduce morbidity, mortality, and antifungal resistance.","key_result":"Mortality from invasive fungal diseases in India approaches 50%, surpassing several nationally prioritised conditions; key pathogens of concern include *Candidozyma auris*, azole-resistant *Aspergillus fumigatus*, and *Trichophyton indotineae*, with COVID-19-associated mucormycosis highlighting critical preparedness gaps.","limitations":"This is a consensus declaration rather than an original research study, so it does not present new primary data; burden estimates are derived from prior literature and may not capture current real-world epidemiology across all Indian regions.","practice_takeaway":"Clinicians should recognise fungal diseases — especially in immunocompromised, critically ill, chronic lung disease, and poorly controlled diabetic patients — as a major, under-prioritised public health threat in India. Proactive antifungal stewardship and early diagnostics are key actions supported by this declaration."}},{"doi":"10.1097/qco.0000000000001180","pmid":"41505800","title":"Skin signs of invasive fungal diseases: diagnostic clues for clinicians","journal_title":"Current Opinion in Infectious Diseases","journal_issn":"0951-7375","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.1097/qco.0000000000001180","source_score":20,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-13","doi":"10.1097/qco.0000000000001180","days":"7","issn":"0951-7375","rank":"6","field":"Clinical Medicine","score":"20","category":"Infectious Diseases","categories":["Infectious Diseases"],"_categories":["Infectious Diseases"]},"pubmed":{"doi":"10.1097/QCO.0000000000001180","title":"Skin signs of invasive fungal diseases: diagnostic clues for clinicians.","journal":"Current opinion in infectious 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Cologne"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Confederation for Medical Mycology (ECMM) Excellence Center, University Hospital Cologne"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany; Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne"}]},{"given":"Rosanne","family":"Sprute","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Confederation for Medical Mycology (ECMM) Excellence Center, University Hospital Cologne"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany; Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne"}]},{"given":"Philipp","family":"Koehler","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Confederation for Medical Mycology (ECMM) Excellence Center, University Hospital Cologne"},{"name":"Division of Clinical Immunology, Department I of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne and Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, Cologne, Germany"}]},{"given":"Harald","family":"Seifert","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany; Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne"},{"name":"Institute for Medical Microbiology, Immunology, and Hygiene, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"}]},{"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Confederation for Medical Mycology (ECMM) Excellence Center, University Hospital Cologne"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany; Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne"},{"name":"Division of Clinical Immunology, Department I of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne and Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, Cologne, 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microscopy or histopathology; include posaconazole and isavuconazole in therapeutic drug monitoring.","limitations":"Access to tests and turnaround times vary across the UK, which may limit implementation; recommendations focus on adults and UK practice, with pediatric and global applicability only discussed, not specified.","practice_takeaway":"Adopt non-culture diagnostics alongside stewardship: order Pneumocystis PCR and 1,3-β-D-glucan when PCP or invasive candidiasis is suspected; use higher-volume respiratory cultures; expand Aspergillus antigen/antibody testing to ICU and chronic lung disease; consider Candida and Mucorales PCR where appropriate; use pan-fungal PCR/sequencing when microscopy or histology is positive; monitor posaconazole and isavuconazole levels."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Mucormycosis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research 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