2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4cf,TP53-mutated (TP53-MT) myeloid neoplasms (MN) represent one of the most challenging disease subsets due to their distinct pathobiology, frequent association with therapy-related disease, chemo-resistant phenotype, and dismal outcomes. The prognostic impact of TP53-MT is not uniform and is influenced by disease state, allelic burden, and co-occurring cytogenetic and molecular aberrations that shape disease trajectory. While current prognostic models incorporate TP53 status, they incompletely capture the heterogeneity within TP53-MT MN. Therapeutic options remain limited, with allogeneic stem cell transplantation being the only intervention offering long-term survival in selected patients. Novel approaches, including p53 reactivators and anti-CD47 antibodies in combination with standard-of-care therapies, have been explored; however, none has yet transformed the natural history of TP53-MT MN. This review highlights the current understanding of TP53-MT MN, evolving strategies of prognostic stratification and propose a practical framework for clinical management. We further discuss the critical unmet need for collaborative, biologically informed clinical trials to improve outcomes of this challenging disease entity.31:T94f, Purpose of review TP53- mutated ( TP53 -MT) myeloid neoplasms (MN) represent one of the most challenging disease subsets due to their distinct pathobiology, frequent association with therapy-related disease, chemo-resistant phenotype, and dismal outcomes. The prognostic impact of TP53 -MT is not uniform and is influenced by disease state, allelic burden, and co-occurring cytogenetic and molecular aberrations that shape disease trajectory. While current prognostic models incorporate TP53 status, they incompletely capture the heterogeneity within TP53 -MT MN. Therapeutic options remain limited, with allogeneic stem cell transplantation being the only intervention offering long-term survival in selected patients. Recent findings Novel approaches, including p53 reactivators and anti-CD47 antibodies in combination with standard-of-care therapies, have been explored; however, none has yet transformed the natural history of TP53 -MT MN. Summary This review highlights the current understanding of TP53 -MT MN, evolving strategies of prognostic stratification and propose a practical framework for clinical management. We further discuss the critical unmet need for collaborative, biologically informed clinical trials to improve outcomes of this challenging disease entity. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Myeloid Neoplasms: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Myeloid Neoplasms (condition). Clinician-written summaries and actionable practice insights. 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(COMMAND)","journal-title":"Leukemia","doi-asserted-by":"crossref"},{"DOI":"10.1182/bloodadvances.2024014499","key":"R60-20260107","year":"2025","issue":null,"author":"Lontos","volume":"9","first-page":"2845","unstructured":null,"article-title":"TP53-mutant variant allele frequency and cytogenetics determine prognostic groups in MDS/AML for transplantation","journal-title":"Blood Adv","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1097/lww.0000000000001000","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Current Opinion in Hematology"],"reference-count":57,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,12,30]]},"references-count":57,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":null},"created_at":"2026-01-11T11:19:33.869Z","updated_at":"2026-01-11T11:19:33.869Z","tags":[{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"category","value":"Hematology","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"condition","value":"Myeloid Neoplasms","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"modality","value":"Allogeneic Stem Cell Transplantation","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"modality","value":"Anti-CD47 Antibody","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"modality","value":"p53 Reactivator","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"warning","value":"Population details (age/sex) and disease subtype breakdown are not specified in the abstract.","value_numeric":null},{"paper_doi":"10.1097/moh.0000000000000906","tag_type":"warning","value":"Review article; not a primary study and lacks numerical outcomes in the abstract.","value_numeric":null}],"summaries":{"what_studied":"Narrative review of TP53‑mutated myeloid neoplasms covering prognostic stratification by disease state, TP53 allelic burden, and co‑occurring cytogenetic/molecular changes, and current and emerging treatments (allogeneic transplant, p53 reactivators, anti‑CD47 antibodies).","key_result":"Allogeneic stem cell transplantation is the only intervention reported to offer long‑term survival in selected patients; novel approaches (p53 reactivators, anti‑CD47 antibodies with standard care) have not yet changed the natural history.","limitations":"Narrative review without quantitative outcomes in the abstract; no sample sizes or effect estimates are provided; prognostic models are noted to incompletely capture heterogeneity within TP53‑mutated disease.","practice_takeaway":"Refer eligible patients for allogeneic transplantation when feasible. Use disease state, TP53 allelic burden, and co‑mutations to refine prognosis; recognize that investigational agents (p53 reactivators, anti‑CD47 antibodies) remain non‑transformative to date."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Myeloid Neoplasms"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Myeloid Neoplasms"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Myeloid Neoplasms"}}}]]

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