2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T718,CPT1 (carnitine palmitoyltransferase 1) is a rate-limiting enzyme for long-chain fatty acid oxidation. In adult hearts, CPT1b predominates, while CPT1a is coexpressed at lower levels. Pathological stress on the heart induces CPT1a expression, coinciding with a reduction in fatty acid oxidation, yet the role of CPT1a in pathological remodeling is unknown. CPT1 isoform expression was assayed in the myocardium of patients with heart failure with nonischemic cardiomyopathy and a preclinical mouse model of heart failure. Mice were subjected to afterload stress via transverse aortic constriction (TAC) or sham surgery (sham) with cardiac-specific CPT1a knockdown or cardiac-specific, adeno-associated virus serotype 9 (AAV9)-mediated CPT1a overexpression (AAV9.cTnT [cardiac troponin T].Cpt1a) versus empty virus or PBS infusions as controls. MicroRNA 370, known to suppress hepatic CPT1a, was assayed and overexpressed to determine if microRNA 370 regulates cardiac CPT1a expression. CPT1a protein was elevated and microRNA 370 reduced in the myocardium of male and female patients with nonischemic cardiomyopathy, as well as in failing mouse hearts. AAV9-mediated microRNA 370 overexpression in mouse hearts suppressed CPT1a expression and attenuated the response of CPT1a to TAC. Preventing CPT1a upregulation in response to TAC in cardiac-specific CPT1a knockout mice exacerbated adverse remodeling, severe dysfunction, and increased mortality. In contrast, CPT1a overexpression (2.8-fold) attenuated impaired ejection fraction (by 54%) versus control TAC hearts ( The effects of CPT1a in the heart extend beyond fatty acid oxidation including noncanonical regulation of gene programs. CPT1a upregulation occurs in nonischemic cardiomyopathy and is a critical cardioprotective adaptation to pathological stress.31:Tb9b, BACKGROUND: CPT1 (carnitine palmitoyltransferase 1) is a rate-limiting enzyme for long-chain fatty acid oxidation. In adult hearts, CPT1b predominates, while CPT1a is coexpressed at lower levels. Pathological stress on the heart induces CPT1a expression, coinciding with a reduction in fatty acid oxidation, yet the role of CPT1a in pathological remodeling is unknown. METHODS: CPT1 isoform expression was assayed in the myocardium of patients with heart failure with nonischemic cardiomyopathy and a preclinical mouse model of heart failure. Mice were subjected to afterload stress via transverse aortic constriction (TAC) or sham surgery (sham) with cardiac-specific CPT1a knockdown or cardiac-specific, adeno-associated virus serotype 9 (AAV9)–mediated CPT1a overexpression (AAV9.cTnT [cardiac troponin T].Cpt1a) versus empty virus or PBS infusions as controls. MicroRNA 370, known to suppress hepatic CPT1a, was assayed and overexpressed to determine if microRNA 370 regulates cardiac CPT1a expression. RESULTS: CPT1a protein was elevated and microRNA 370 reduced in the myocardium of male and female patients with nonischemic cardiomyopathy, as well as in failing mouse hearts. AAV9–mediated microRNA 370 overexpression in mouse hearts suppressed CPT1a expression and attenuated the response of CPT1a to TAC. Preventing CPT1a upregulation in response to TAC in cardiac-specific CPT1a knockout mice exacerbated adverse remodeling, severe dysfunction, and increased mortality. In contrast, CPT1a overexpression (2.8-fold) attenuated impaired ejection fraction (by 54%) versus control TAC hearts ( P <0.05). Delivery of AAV9.cTnT.Cpt1a 4 weeks after TAC surgery led to significant rescue of ejection fraction and mitigated the exacerbated dysfunction of cardiac-specific CPT1a knockout mice TAC hearts. RNA-seq revealed a novel function of CPT1a in suppressing hypertrophic, profibrotic, and cell death gene programs in both sham and TAC hearts, irrespective of changes in fatty acid oxidation, with reduced histone acetylation. CONCLUSIONS: The effects of CPT1a in the heart extend beyond fatty acid oxidation including noncanonical regulation of gene programs. CPT1a upregulation occurs in nonischemic cardiomyopathy and is a critical cardioprotective adaptation to pathological stress. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Nonischemic Cardiomyopathy: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Nonischemic Cardiomyopathy (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Nonischemic%20Cardiomyopathy\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Nonischemic Cardiomyopathy\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Nonischemic%20Cardiomyopathy\"}]}}"}}]],["$","$L2f",null,{"title":"Nonischemic Cardiomyopathy: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Nonischemic Cardiomyopathy with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1016/j.healun.2026.05.025","pmid":"42276265","title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 2026 Adult Heart Transplantation: A Contemporary Analysis of Trends and Outcomes by Recipient Sex","journal_title":"The Journal of Heart and Lung Transplantation","journal_issn":"1053-2498","published_at":"2026-06-11T00:00:00.000Z","url":"https://doi.org/10.1016/j.healun.2026.05.025","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-19T13:23:24.844Z","updated_at":"2026-06-19T13:23:24.844Z","tags":[{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"condition","value":"Congenital Heart Disease","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"condition","value":"Heart Failure","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"condition","value":"Hypertrophic Cardiomyopathy","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"condition","value":"Nonischemic Cardiomyopathy","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"modality","value":"Heart Transplantation","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"modality","value":"Left Ventricular Assist Device","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"modality","value":"Mechanical Circulatory Support","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"sample_size","value":"n=50614","value_numeric":50614},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"study_design","value":"Registry-Based Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"warning","value":"Predicted heart mass difference was included as a covariate but may not fully account for size-related risk, a known confounder in sex-mismatch analyses.","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"warning","value":"The impact_flag 'practice_changing' is applied cautiously — findings support refined matching strategies but do not yet establish a new standard of care. Confirmatory prospective data are lacking.","value_numeric":null},{"paper_doi":"10.1016/j.healun.2026.05.025","tag_type":"warning","value":"The study spans 2005–2023, so findings may reflect heterogeneous allocation policies across jurisdictions and eras; generalizability to current practice varies by region.","value_numeric":null}],"summaries":{"what_studied":"Sex-based differences in recipient profiles, donor selection, mechanical support strategies, and outcomes (1-year survival and 5-year conditional survival) among 50,614 adults undergoing primary heart-alone transplantation from 2005–2023, using the ISHLT Registry.","key_result":"1-year survival improved over time and was similar between sexes within eras. After multivariable adjustment, female donor–female recipient pairing had higher 1-year mortality vs. male donor–male recipient (HR 1.12, 95% CI 1.02–1.22), and male donor–female recipient pairing had higher 5-year conditional mortality (HR 1.17, 95% CI 1.04–1.31).","limitations":"Registry-based observational design limits causal inference. Adjustment for predicted heart mass difference may not fully capture size mismatch. Selection biases in donor-recipient pairing cannot be fully excluded.","practice_takeaway":"Donor-recipient sex pairing carries measurable mortality risk even after adjustment — female recipients receiving male donor hearts face worse long-term outcomes. Matching strategies that incorporate size, immunologic status, and clinical risk factors should be considered for female heart transplant recipients."}},{"doi":"10.1161/circresaha.125.327403","pmid":"41342119","title":"CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer","journal_title":"Circulation Research","journal_issn":"0009-7330","published_at":"2025-12-04T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12811910/","source_score":33,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1161/circresaha.125.327403","days":"7","issn":"0009-7330","rank":"3","field":"Clinical Medicine","score":"33","category":"Hematology","categories":["Hematology"],"_categories":["Hematology"]},"pubmed":{"doi":"10.1161/CIRCRESAHA.125.327403","title":"CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.","journal":"Circulation research","methods":"","results":"CPT1a protein was elevated and microRNA 370 reduced in the myocardium of male and female patients with nonischemic cardiomyopathy, as well as in failing mouse hearts. AAV9-mediated microRNA 370 overexpression in mouse hearts suppressed CPT1a expression and attenuated the response of CPT1a to TAC. Preventing CPT1a upregulation in response to TAC in cardiac-specific CPT1a knockout mice exacerbated adverse remodeling, severe dysfunction, and increased mortality. In contrast, CPT1a overexpression (2.8-fold) attenuated impaired ejection fraction (by 54%) versus control TAC hearts (","abstract":"$30","keywords":["carnitine o-palmitoyltransferase","heart failure","metabolism"],"pubmed_id":"41342119","conclusions":"","publication_date":"2025-12-04T00:00:00"},"crossref":{"DOI":"10.1161/circresaha.125.327403","URL":"https://doi.org/10.1161/circresaha.125.327403","ISSN":["0009-7330","1524-4571"],"link":[{"URL":"https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.125.327403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"2","score":1,"title":["CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer"],"author":[{"given":"Andrew N.","family":"Carley","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Santosh K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Chandan K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Amy","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics (A.W.), The Ohio State University, Columbus."}]},{"given":"Azariyas A.","family":"Challa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."}]},{"given":"Tatiana","family":"Gromova","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Medicine and Physiology, University of California, Los Angeles (T.G., T.M.V.)."}]},{"given":"Thomas M.","family":"Vondriska","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Medicine and Physiology, University of California, Los Angeles (T.G., T.M.V.)."}]},{"given":"Zhentao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery (Z.Z., H.Z.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Surgery (Z.Z., H.Z.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]},{"given":"Ahlke","family":"Heydemann","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Illinois at Chicago (A.H.)."}]},{"given":"Kenneth C.","family":"Bedi","sequence":"additional","affiliation":[{"name":"Smilow Translational Research Center, Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia (K.C.B., K.B.M.)."}]},{"given":"Christos P.","family":"Kyriakopoulos","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City (C.P.K., C.H.S., S.G.D.)."},{"name":"Division of Cardiovascular Medicine (C.P.K., S.G.D.), University of Utah Health, Salt Lake City."}]},{"given":"Craig H.","family":"Selzman","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City (C.P.K., C.H.S., S.G.D.)."},{"name":"Division of Cardiothoracic Surgery (C.H.S.), University of Utah Health, Salt Lake City."}]},{"given":"Stavros G.","family":"Drakos","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City (C.P.K., C.H.S., S.G.D.)."},{"name":"Division of Cardiovascular Medicine (C.P.K., S.G.D.), University of Utah Health, Salt Lake City."}]},{"given":"Kenneth B.","family":"Margulies","sequence":"additional","affiliation":[{"name":"Smilow Translational Research Center, Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia (K.C.B., K.B.M.)."}]},{"given":"E. Douglas","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.N.C., S.K.M., C.K.M., Y.W., A.A.C., E.D.L.), The Ohio State University College of Medicine, Columbus."},{"name":"Davis Heart and Lung Research Institute (A.N.C., S.K.M., C.K.M., Y.W., Z.Z., H.Z., E.D.L.), The Ohio State University, Columbus."}]}],"issued":{"date-parts":[[2026,1,16]]},"member":"276","prefix":"10.1161","source":"Crossref","volume":"138","created":{"date-time":"2025-12-04T10:00:16Z","timestamp":1764842416000,"date-parts":[[2025,12,4]]},"indexed":{"date-time":"2026-01-21T01:35:13Z","timestamp":1768959313599,"date-parts":[[2026,1,21]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.125.327403"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-08-26"},{"name":"revised","group":{"name":"publication_history","label":"Publication History"},"label":"Revised","order":1,"value":"2025-10-21"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-11-17"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-12-04"}],"deposited":{"date-time":"2026-01-20T13:09:11Z","timestamp":1768914551000,"date-parts":[[2026,1,20]]},"issn-type":[{"type":"print","value":"0009-7330"},{"type":"electronic","value":"1524-4571"}],"published":{"date-parts":[[2026,1,16]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":[{"DOI":"10.1023/a:1015332726303","key":"e_1_3_3_2_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.bbamcr.2012.08.015","key":"e_1_3_3_3_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1074/jbc.270.15.8952","key":"e_1_3_3_4_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1152/ajpheart.00461.2002","key":"e_1_3_3_5_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.106.668665","key":"e_1_3_3_6_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCHEARTFAILURE.117.003864","key":"e_1_3_3_7_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/s0163-7827(01)00024-8","key":"e_1_3_3_8_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/cvr/cvr071","key":"e_1_3_3_9_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCRESAHA.114.301863","key":"e_1_3_3_10_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/s0735-1097(02)01967-8","key":"e_1_3_3_11_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.nuclcard.2006.01.021","key":"e_1_3_3_12_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCRESAHA.112.274456","key":"e_1_3_3_13_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1042/bj2140021","key":"e_1_3_3_14_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.lfs.2004.11.032","key":"e_1_3_3_15_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/cvr/cvr249","key":"e_1_3_3_16_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1006/jmcc.1996.0085","key":"e_1_3_3_17_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1194/jlr.M004812","key":"e_1_3_3_18_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.119.039610","key":"e_1_3_3_19_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCHEARTFAILURE.114.001496","key":"e_1_3_3_20_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/mrm.1910350203","key":"e_1_3_3_21_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1006/jmcc.1996.0092","key":"e_1_3_3_22_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jacbts.2022.10.009","key":"e_1_3_3_23_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jacbts.2023.07.009","key":"e_1_3_3_24_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/s41591-018-0046-2","key":"e_1_3_3_25_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s12859-019-3251-1","key":"e_1_3_3_26_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/nmeth.3317","key":"e_1_3_3_27_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/bioinformatics/btt656","key":"e_1_3_3_28_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/nar/gkv007","key":"e_1_3_3_29_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.120.052671","key":"e_1_3_3_30_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/s44161-022-00117-6","key":"e_1_3_3_31_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/jgm.2673","key":"e_1_3_3_32_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/gt.2010.105","key":"e_1_3_3_33_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/s41586-023-06585-5","key":"e_1_3_3_34_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/nar/gkx441","key":"e_1_3_3_35_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.yjmcc.2021.10.002","key":"e_1_3_3_36_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/cvr/cvr215","key":"e_1_3_3_37_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/hc4901.100526","key":"e_1_3_3_38_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1152/ajpheart.00864.2003","key":"e_1_3_3_39_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCULATIONAHA.115.017545","key":"e_1_3_3_40_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1126/science.abc8861","key":"e_1_3_3_41_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/s41598-020-67790-0","key":"e_1_3_3_42_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1172/JCI17061","key":"e_1_3_3_43_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_3_44_2","year":"2004","issue":null,"author":"Kasama S","volume":"45","first-page":"1108","unstructured":"Kasama S, Toyama T, Kumakura H, Takayama Y, Ishikawa T, Ichikawa S, Suzuki T, Kurabayashi M. Effects of intravenous atrial natriuretic peptide on cardiac sympathetic nerve activity in patients with decompensated congestive heart failure. J Nucl Med. 2004;45:1108.","article-title":"Effects of intravenous atrial natriuretic peptide on cardiac sympathetic nerve activity in patients with decompensated congestive heart failure.","journal-title":"J Nucl Med","doi-asserted-by":null},{"DOI":"10.1038/s41419-020-02936-6","key":"e_1_3_3_45_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.1315155110","key":"e_1_3_3_46_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/cvr/cvaa233","key":"e_1_3_3_47_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/CIRCRESAHA.114.302653","key":"e_1_3_3_48_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1172/JCI14190","key":"e_1_3_3_49_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/01.hyp.37.3.833","key":"e_1_3_3_50_2","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,16]]}},"update-policy":"https://doi.org/10.1161/crossmarkpolicy","alternative-id":["10.1161/CIRCRESAHA.125.327403"],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"original-title":[],"container-title":["Circulation Research"],"published-print":{"date-parts":[[2026,1,16]]},"reference-count":49,"published-online":null,"references-count":49,"short-container-title":["Circulation Research"],"is-referenced-by-count":1},"unpaywall":{"doi":"10.1161/circresaha.125.327403","is_oa":true,"title":"CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer","updated":"2026-01-20T20:11:15+00:00","published_date":"2025-12-04","best_oa_location":{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12811910/","pmh_id":"oai:pubmedcentral.nih.gov:12811910","url_for_pdf":null,"url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12811910/"}}},"created_at":"2026-01-17T09:03:27.421Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"category","value":"Hematology","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"condition","value":"Heart Failure","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"condition","value":"Nonischemic Cardiomyopathy","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"modality","value":"Gene Therapy","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"study_design","value":"Preclinical Study","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"warning","value":"Abstract text appears truncated; sample sizes, timing, and exact mortality rates are not provided.","value_numeric":null},{"paper_doi":"10.1161/circresaha.125.327403","tag_type":"warning","value":"Design spans human myocardial expression assays and mouse TAC experiments; design label is approximate.","value_numeric":null}],"summaries":{"what_studied":"Measured CPT1 isoform and microRNA-370 in myocardium from patients with nonischemic cardiomyopathy and in a mouse TAC model; tested cardiac-specific CPT1a knockdown, AAV9-mediated CPT1a overexpression, and microRNA-370 overexpression to define regulation and function.","key_result":"CPT1a rose and microRNA-370 fell in failing human and mouse hearts; blocking CPT1a upregulation worsened remodeling, dysfunction, and mortality, while 2.8-fold CPT1a overexpression cut TAC-induced ejection fraction impairment by 54% versus controls.","limitations":"Functional results are from a mouse TAC model with gene manipulation, while human data are limited to myocardial expression without clinical outcomes. Sample sizes and follow-up duration are not reported here."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Nonischemic Cardiomyopathy"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Nonischemic Cardiomyopathy"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Nonischemic Cardiomyopathy"}}}]]

Papers