2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T470,This study aimed to determine the influence of nosocomial bacterial and viral infections of preterm very low birth weight (VLBW) infants on neurodevelopmental outcome and on rehospitalization rates during the first two years of life. Retrospective single-center cohort study including preterm infant born between 2010 and 2018 and followed until two years of age corrected for prematurity (Bayley scales). Of 620 study infants 418 without neurodevelopmental impairment (NDI). were compared to 202 infants with NDI. Single or multiple nosocomial infections were not risk factors for NDI in a multivariate logistic regression model checked for multicollinearity. Infants with NDI were of younger gestational age, had lower birth weights and higher rates of neonatal complications (ileus, periventricular leukomalacia, and bronchopulmonary dysplasia). Nosocomial infection were also not risk factors for rehospitalizations by infectious diseases. Nosocomial infections did not significantly influence NDI and rehospitalization rates in preterm VLBW infants. The study was registered at "Deutsches Register Klinischer Studien" DRKS00019000.31:T79c,Abstract Objective This study aimed to determine the influence of nosocomial bacterial and viral infections of preterm very low birth weight (VLBW) infants on neurodevelopmental outcome and on rehospitalization rates during the first two years of life. Study design Retrospective single-center cohort study including preterm infant born between 2010 and 2018 and followed until two years of age corrected for prematurity (Bayley scales). Results Of 620 study infants 418 without neurodevelopmental impairment (NDI). were compared to 202 infants with NDI. Single or multiple nosocomial infections were not risk factors for NDI in a multivariate logistic regression model checked for multicollinearity. Infants with NDI were of younger gestational age, had lower birth weights and higher rates of neonatal complications (ileus, periventricular leukomalacia, and bronchopulmonary dysplasia). Nosocomial infection were also not risk factors for rehospitalizations by infectious diseases. Conclusions Nosocomial infections did not significantly influence NDI and rehospitalization rates in preterm VLBW infants. Trial registration number The study was registered at “Deutsches Register Klinischer Studien” DRKS00019000. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Nosocomial Infection: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Nosocomial Infection (condition). Clinician-written summaries and actionable practice insights. 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Outcomes included positivity rates, asymptomatic case detection, screening specificity, and cost per detected case.","key_result":"Of 111,271 screened individuals, 705 (0.6%) tested positive. Screening newly identified 236 cases (0.2%), of whom 110 (0.1%) were truly asymptomatic with no known exposure — detectable only via RT-qPCR. Screening specificity was 99.997% (3 false positives). Mean cost per detected case was €8,082.87 vs. €6,868.58 for a hypothetical RDT strategy, but the RDT approach would have missed an estimated 462 infected individuals given its 34.5% sensitivity in screening use.","limitations":"- ~90% staff compliance means some infections may have been missed, inflating the true positivity rate.\n- Incomplete follow-up for asymptomatic patients discharged early; some may have been misclassified as asymptomatic rather than pre-symptomatic.\n- Cost analysis used EBM billing rates and excluded labour, transport, and downstream nosocomial outbreak costs, so true cost-effectiveness cannot be determined.","practice_takeaway":"Universal RT-qPCR admission screening reliably detected asymptomatic SARS-CoV-2 carriers (1 in 830 screened) with near-perfect specificity, supporting its use as a targeted infection control tool during high-incidence periods or emergence of clinically severe variants. Screening intensity should be scaled to community transmission levels, as cost-per-case rises sharply during low-incidence phases."}},{"doi":"10.1038/s41372-026-02681-2","pmid":"42086726","title":"Impact of nosocomial infections on neurodevelopmental outcome and rehospitalization rate in preterm infants with birth weight below 1500 g (NINO study)","journal_title":"Journal of Perinatology","journal_issn":"0743-8346","published_at":"2026-05-06T00:00:00.000Z","url":"https://doi.org/10.1038/s41372-026-02681-2","source_score":10,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-08","doi":"10.1038/s41372-026-02681-2","days":"7","issn":"0743-8346","rank":"2","field":"Clinical Medicine","score":"10","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1038/s41372-026-02681-2","title":"Impact of nosocomial infections on neurodevelopmental outcome and rehospitalization rate in preterm infants with birth weight below 1500 g (NINO study).","journal":"Journal of perinatology : official journal of the California Perinatal Association","methods":"","results":"Of 620 study infants 418 without neurodevelopmental impairment (NDI). were compared to 202 infants with NDI. Single or multiple nosocomial infections were not risk factors for NDI in a multivariate logistic regression model checked for multicollinearity. Infants with NDI were of younger gestational age, had lower birth weights and higher rates of neonatal complications (ileus, periventricular leukomalacia, and bronchopulmonary dysplasia). Nosocomial infection were also not risk factors for rehospitalizations by infectious diseases.","abstract":"$30","keywords":[],"pubmed_id":"42086726","conclusions":"","publication_date":"2026-05-06T00:00:00"},"crossref":{"DOI":"10.1038/s41372-026-02681-2","URL":"https://doi.org/10.1038/s41372-026-02681-2","ISSN":["0743-8346","1476-5543"],"link":[{"URL":"https://www.nature.com/articles/s41372-026-02681-2.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41372-026-02681-2","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41372-026-02681-2.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Impact of nosocomial infections on neurodevelopmental outcome and rehospitalization rate in preterm infants with birth weight below 1500 g (NINO study)"],"author":[{"given":"Elisabeth","family":"Resch-Poteralski","sequence":"first","affiliation":[]},{"given":"Ute","family":"Maurer-Fellbaum","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Eichberger","sequence":"additional","affiliation":[]},{"given":"Volker","family":"Strenger","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Krause","sequence":"additional","affiliation":[]},{"given":"Elisabeth","family":"Pichler-Stachl","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Avian","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Resch","sequence":"additional","affiliation":[]},{"given":"Berndt","family":"Urlesberger","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,5,5]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-05-05T08:16:08Z","timestamp":1777968968000,"date-parts":[[2026,5,5]]},"indexed":{"date-time":"2026-05-05T09:11:28Z","timestamp":1777972288473,"date-parts":[[2026,5,5]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000,"date-parts":[[2026,5,5]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000,"date-parts":[[2026,5,5]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41372-026-02681-2"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"23 January 2026"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"6 March 2026"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"31 March 2026"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"5 May 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"The authors declare no competing interests."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"},"order":2,"value":"by the local ethic committee of the Medical University of Graz ID 31-396 ex 18/19. 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NDI was instead associated with younger gestational age, lower birth weight, and higher rates of ileus, periventricular leukomalacia, and bronchopulmonary dysplasia.","limitations":"Retrospective single-center design limits generalizability. Follow-up only to 2 years corrected age may miss later neurodevelopmental effects. No detail provided on infection types, severity, or pathogens.","practice_takeaway":"Nosocomial infections alone do not appear to drive NDI or rehospitalization risk in VLBW preterm infants — prematurity severity and neonatal complications (BPD, PVL) remain the dominant risk factors. Clinicians should focus neurodevelopmental surveillance resources on the youngest, smallest, and most complication-prone infants."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Nosocomial Infection"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Nosocomial Infection"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Nosocomial Infection"}}}]]

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