Journal of Investigative Dermatology

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Korea Ministry of Health and Welfare

Seoul National University

National Research Foundation of Korea

Low-dose UV radiation before running wheel access activates brown adipose tissue

J Endocrinol

Neurohormonal regulation of appetite and its relationship with stress: a mini literature review

Cureus

Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats

Horm Behav

Browning of white adipose tissue: lessons from experimental models

Horm Mol Biol Clin Investig

Leptin and brain-adipose crosstalks

Nat Rev Neurosci

Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

Front Cardiovasc Med

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

J Clin Invest

Physiology of energy homeostasis: models, actors, challenges and the glucoadipostatic loop

Metabolism

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Nature

Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue

Diabetologia

Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet

Clin Exp Immunol

Exposure to solar ultraviolet radiation limits diet-induced weight gain, increases liver triglycerides and prevents the early signs of cardiovascular disease in mice

Nutr Metab Cardiovasc Dis

Norepinephrine release may play a critical role in the Warburg effect: an integrative model of tumorigenesis

Neoplasma

Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

Sun exposure and its effects on human health: mechanisms through which sun exposure could reduce the risk of developing obesity and cardiometabolic dysfunction

Int J Environ Res Public Health

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet

Diabetes

Systematic review of the effects of ultraviolet radiation on markers of metabolic dysfunction

Clin Biochem Rev

The energy balance model of obesity: beyond calories in, calories out

Am J Clin Nutr

UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation

Sci Rep

Adipose tissue browning in mice and humans

Abnormal glucocorticoid synthesis in the lesional skin of erythematotelangiectatic rosacea

J Invest Dermatol

Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin-releasing hormone secretion in adrenalectomized mice

J Nutr

Brown and beige fat: physiological roles beyond heat generation

Cell Metab

UV modulation of subcutaneous fat metabolism

UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin

Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice

Mech Ageing Dev

Brown fat and browning for the treatment of obesity and related metabolic disorders

Diabetes Metab J

Induction of adipose tissue browning as a strategy to combat obesity

Int J Mol Sci

Obesity: a neuroimmunometabolic perspective

Nat Rev Endocrinol

Overview of energy intake, physical activity, and neuronal substances on obesity

Food Life

Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

Nutr Metab (Lond)

Biological control of appetite: a daunting complexity

Obesity (Silver Spring)

Neurobiology of food intake in health and disease

Food-seeking behavior is triggered by skin ultraviolet exposure in males

Nat Metab

Impact of ultraviolet radiation on cardiovascular and metabolic disorders: the role of nitric oxide and vitamin D

Photodermatol Photoimmunol Photomed

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

The selective dopamine β-hydroxylase inhibitor nepicastat attenuates multiple aspects of cocaine-seeking behavior

Neuropsychopharmacology

Brown fat in humans: turning up the heat on obesity

Incendiary leptin

Nutrients

Multifaceted roles of beige fat in energy homeostasis beyond UCP1

Endocrinology

Agouti-related protein neuron circuits that regulate appetite

Neuroendocrinology

Serum level of adiponectin increases and those of leptin and resistin decrease following the treatment of psoriasis

J Dermatol

Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons

Regular exposure to non-burning ultraviolet radiation reduces signs of non-alcoholic fatty liver disease in mature adult mice fed a high fat diet: results of a pilot study

BMC Res Notes

Hypothalamic control of energy expenditure and thermogenesis

Exp Mol Med

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes

J Biol Chem

Adipocytes as a new source of catecholamine production

FEBS Lett

Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum

Proc Natl Acad Sci U S A

Molecular mechanisms of appetite regulation

Vitamin D receptor targets hepatocyte nuclear factor 4α and mediates protective effects of vitamin D in nonalcoholic fatty liver disease

Leptin function and regulation

Compr Physiol

UV irradiation of the human skin downregulates lipid synthesis and adipokine production in subcutaneous fat. Recent evidence has suggested that UV exposure limits body weight gain in mouse models of obesity. However, the relationship between norepinephrine and UV irradiation has not been previously reported. Chronic UV exposure stimulated food intake but prevented body weight gain. Leptin, an appetite-suppressing hormone, was significantly reduced in the serum of the UV-irradiated mice. In contrast, UV irradiation induced browning of subcutaneous white adipose tissues without increasing physical activity. Notably, UV irradiation significantly increased norepinephrine levels, and the inhibition of norepinephrine production reversed the effects of chronic UV irradiation on food intake and body weight gain. In conclusion, chronic UV irradiation induces norepinephrine release, resulting in the stimulation of food intake due to the downregulation of leptin levels, but it prevents weight gain by inducing the browning process and elevating energy expenditure.

UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice.

UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice

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