2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T663,It is unknown if ocular migraine patients have an increased risk of cerebrovascular disease. This study aimed to determine if cerebrovascular and cardiovascular events were elevated among those with ocular migraine compared to controls. This cohort study utilised a platform of aggregate, de-identified electronic health record data to identify patients with a diagnostic code for ocular migraine based on ICD codes (n = 21,949). Ocular migraine patients were compared to ophthalmology (n = 1,492,348), migraine with aura (MA) (n = 129,099) and migraine without aura (MO) controls. Cohorts were propensity score matched on current age, sex, race/ethnicity, diabetes, essential hypertension, lipoprotein disorders, atherosclerosis and body mass index. Risk ratios and 95% confidence intervals were calculated. A risk ratio between 0.9 and 1.1 was considered not significant. Compared with ophthalmology controls ≥ 50 years old, patients with a diagnostic code ocular migraine had an increased risk of all outcomes, with a risk ratio of 1.48 (95% CI 1.33, 1.64), transient ischemic stroke 2.68 (2.20, 3.27) and cerebral infarct 1.81 (1.55, 2.10). These findings continued to be significant among the ≥ 65 years old cases and controls. Compared to patients with MA or MO, patients had a comparable risk of all outcomes (p > 0.05). Patients with a diagnostic code for ocular migraine ≥ 50 years old had a 48% increased risk of cerebrovascular and cardiovascular outcomes, compared to ophthalmology controls. Future retrospective and prospective cohort analyses are needed to further verify these findings.31:Ta5e,Abstract Background It is unknown if ocular migraine patients have an increased risk of cerebrovascular disease. This study aimed to determine if cerebrovascular and cardiovascular events were elevated among those with ocular migraine compared to controls. Methods This cohort study utilised a platform of aggregate, de-identified electronic health record data to identify patients with a diagnostic code for ocular migraine based on ICD codes ( n = 21,949). Ocular migraine patients were compared to ophthalmology ( n = 1,492,348), migraine with aura (MA) ( n = 129,099) and migraine without aura (MO) controls. Cohorts were propensity score matched on current age, sex, race/ethnicity, diabetes, essential hypertension, lipoprotein disorders, atherosclerosis and body mass index. Risk ratios and 95% confidence intervals were calculated. A risk ratio between 0.9 and 1.1 was considered not significant. Results Compared with ophthalmology controls ≥ 50 years old, patients with a diagnostic code ocular migraine had an increased risk of all outcomes, with a risk ratio of 1.48 (95% CI 1.33, 1.64), transient ischemic stroke 2.68 (2.20, 3.27) and cerebral infarct 1.81 (1.55, 2.10). These findings continued to be significant among the ≥ 65 years old cases and controls. Compared to patients with MA or MO, patients had a comparable risk of all outcomes ( p > 0.05). Conclusion Patients with a diagnostic code for ocular migraine ≥ 50 years old had a 48% increased risk of cerebrovascular and cardiovascular outcomes, compared to ophthalmology controls. Future retrospective and prospective cohort analyses are needed to further verify these findings. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Ocular Migraine: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Ocular Migraine (condition). Clinician-written summaries and actionable practice insights. 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These findings continued to be significant among the ≥ 65 years old cases and controls. Compared to patients with MA or MO, patients had a comparable risk of all outcomes (p > 0.05).","abstract":"$30","keywords":[],"pubmed_id":"42056483","conclusions":"Patients with a diagnostic code for ocular migraine ≥ 50 years old had a 48% increased risk of cerebrovascular and cardiovascular outcomes, compared to ophthalmology controls. Future retrospective and prospective cohort analyses are needed to further verify these findings.","publication_date":"2026-04-30T00:00:00"},"crossref":{"DOI":"10.1038/s41433-026-04479-0","URL":"https://doi.org/10.1038/s41433-026-04479-0","ISSN":["0950-222X","1476-5454"],"link":[{"URL":"https://www.nature.com/articles/s41433-026-04479-0.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41433-026-04479-0","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41433-026-04479-0.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine"],"author":[{"given":"Jacqueline K.","family":"Shaia","sequence":"first","affiliation":[]},{"given":"Priya","family":"Shukla","sequence":"additional","affiliation":[]},{"given":"Hayden","family":"Reed","sequence":"additional","affiliation":[]},{"given":"David C.","family":"Kaelber","sequence":"additional","affiliation":[]},{"given":"Rishi P.","family":"Singh","sequence":"additional","affiliation":[]},{"given":"Katherine E.","family":"Talcott","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/100000053","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000053","name":"U.S. Department of Health & Human Services | NIH | National Eye Institute","award":["T32 EY024236"],"award-info":[{"award-number":["T32 EY024236"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100001818","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100001818","name":"Research to Prevent Blindness","award":["P30EY025585(BA-A)"],"award-info":[{"award-number":["P30EY025585(BA-A)"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100001818","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100001818","name":"Research to Prevent Blindness","award":["P30EY025585(BA-A)"],"award-info":[{"award-number":["P30EY025585(BA-A)"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,4,29]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-04-29T06:13:27Z","timestamp":1777443207000,"date-parts":[[2026,4,29]]},"indexed":{"date-time":"2026-05-01T12:39:36Z","timestamp":1777639176990,"date-parts":[[2026,5,1]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41433-026-04479-0"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"17 March 2025"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"15 January 2026"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"14 April 2026"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"29 April 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"RPS reports personal fees from Apellis, Iveric Bio, Eyepoint, Regenxbio, Genentech, Bausch and Lomb, Zeiss, Alcon, and Regeneron, and research grants from Janssen. KET: Alimera (consultant), AbbVie (consultant), Apellis (consultant), Astellas (Speaker’s bureau), Eyepoint (consultant), Genentech (consultant, speaker’s bureau), Outlook (consultant), Regeneron (consultant, research), Zeiss (speaker, research, consultant). JKS: Impact Education—Regeneron Pharmaceuticals, Inc. The authors declare no competing interests."}],"deposited":{"date-time":"2026-04-29T06:13:32Z","timestamp":1777443212000,"date-parts":[[2026,4,29]]},"issn-type":[{"type":"print","value":"0950-222X"},{"type":"electronic","value":"1476-5454"}],"published":{"date-parts":[[2026,4,29]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":null,"key":"4479_CR1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Murphy SL, Kochanek KD, Xu J, Arias E. Mortality in the United States, 2014. Key findings, Data from the National Vital Statistics System, Mortality. Published online in 2014. 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Retinal migraine reappraised. Cephalalgia. 2006;26:1275–86. https://doi.org/10.1111/J.1468-2982.2006.01206.X.","article-title":null,"journal-title":"Cephalalgia","doi-asserted-by":"publisher"},{"DOI":"10.1212/01.WNL.0000294329.93565.94","key":"4479_CR22","year":"2008","issue":null,"author":"ST Lee","volume":"70","first-page":"1510","unstructured":"Lee ST, Chu K, Jung KH, Kim DH, Kim EH, Choe VN, et al. Decreased number and function of endothelial progenitor cells in patients with migraine. 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Referral for vascular risk factor assessment and closer cardiovascular follow-up may be warranted in this age group."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Ocular Migraine"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Ocular Migraine"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Ocular Migraine"}}}]]

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