2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T92a,There are limited means to predict which crewmembers are at risk for developing optic disc edema (ODE) during spaceflight. Identifying crewmembers who have a low probability of developing ODE will allow for reduced monitoring and countermeasure resources, thereby enabling alternate mission activities. To determine if magnitude of ODE early in flight is associated with magnitude of ODE later in flight. This cohort study involved crewmembers on board the International Space Station. Participants were astronauts who had optical coherence tomography (OCT) imaging before, during, after their spaceflight mission. Preflight and in-flight total retinal thickness (TRT) was quantified within the annular region from Bruch membrane opening to 250 μm using OCT. The change (Δ) in TRT is an objective approach to quantifying ODE. Spaceflight missions lasting approximately 6 months long. Preflight to in-flight ΔTRT. Data were analyzed using linear and log-binomial mixed effects models to determine (1) if ΔTRT on flight day (FD) 30 was associated with ΔTRT on FD150 and (2) the probability a crewmember with ΔTRT less than 20 μm on FD30 would exhibit ΔTRT less than 55 μm on FD150 or a crewmember with ΔTRT of 20 of 55 μm on FD30 would develop ΔTRT greater than 55 μm on FD150. Data from 43 ISS crewmembers (mean [SD] age, 47 [7] years; 35 males [81%] and 8 females [19%]) with a mean (SD) flight duration of 198 (55) days were included. There was an association between FD30 ΔTRT and FD150 ΔTRT (repeated-measure correlation coefficient = 0.89; 95% CI, 0.80-0.94; P < .001). Eyes with ΔTRT less than 20 on FD30 had 2% probability (95% CI, 1%-15%) of ΔTRT of 55 μm or greater on FD150. Receiver operating curve analysis determined an optimal threshold ΔTRT of greater than 29 μm on FD30 to distinguish eyes at risk of ΔTRT of 55 μm or greater on FD150. Eyes with ΔTRT of 20 to 55 μm or 29 to 55 μm on FD30 had a 34% (95% CI, 19%-60%) or 58% (95% CI, 37%-90%) probability, respectively, of ΔTRT of 55 μm or greater on FD150. Findings suggest crewmembers who did not develop ODE on FD30 were unlikely to develop clinically concerning ODE on FD150. The data suggest that OCT imaging during spaceflight missions provides an opportunity to predict the magnitude of ODE that may develop during a longer-lasting mission.31:Te89, Importance There are limited means to predict which crewmembers are at risk for developing optic disc edema (ODE) during spaceflight. Identifying crewmembers who have a low probability of developing ODE will allow for reduced monitoring and countermeasure resources, thereby enabling alternate mission activities. Objective To determine if magnitude of ODE early in flight is associated with magnitude of ODE later in flight. Design, Setting, and Participants This cohort study involved crewmembers on board the International Space Station. Participants were astronauts who had optical coherence tomography (OCT) imaging before, during, after their spaceflight mission. Preflight and in-flight total retinal thickness (TRT) was quantified within the annular region from Bruch membrane opening to 250 μm using OCT. The change (Δ) in TRT is an objective approach to quantifying ODE. Exposure Spaceflight missions lasting approximately 6 months long. Main Outcomes and Measures Preflight to in-flight ΔTRT. Data were analyzed using linear and log-binomial mixed effects models to determine (1) if ΔTRT on flight day (FD) 30 was associated with ΔTRT on FD150 and (2) the probability a crewmember with ΔTRT less than 20 μm on FD30 would exhibit ΔTRT less than 55 μm on FD150 or a crewmember with ΔTRT of 20 of 55 μm on FD30 would develop ΔTRT greater than 55 μm on FD150. Results Data from 43 ISS crewmembers (mean [SD] age, 47 [7] years; 35 males [81%] and 8 females [19%]) with a mean (SD) flight duration of 198 (55) days were included. There was an association between FD30 ΔTRT and FD150 ΔTRT (repeated-measure correlation coefficient = 0.89; 95% CI, 0.80-0.94; P &lt; .001). Eyes with ΔTRT less than 20 on FD30 had 2% probability (95% CI, 1%-15%) of ΔTRT of 55 μm or greater on FD150. Receiver operating curve analysis determined an optimal threshold ΔTRT of greater than 29 μm on FD30 to distinguish eyes at risk of ΔTRT of 55 μm or greater on FD150. Eyes with ΔTRT of 20 to 55 μm or 29 to 55 μm on FD30 had a 34% (95% CI, 19%-60%) or 58% (95% CI, 37%-90%) probability, respectively, of ΔTRT of 55 μm or greater on FD150. Conclusions and Relevance Findings suggest crewmembers who did not develop ODE on FD30 were unlikely to develop clinically concerning ODE on FD150. The data suggest that OCT imaging during spaceflight missions provides an opportunity to predict the magnitude of ODE that may develop during a longer-lasting mission. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Optic Disc Edema: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Optic Disc Edema (condition). Clinician-written summaries and actionable practice insights. 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Space medicine teams can use this as baseline evidence when counseling astronauts about multi-mission risk, while noting that long-term functional consequences of cumulative exposures remain unresolved."}},{"doi":"10.1001/jamaophthalmol.2026.1054","pmid":"42060285","title":"Different Predictors for Components of Spaceflight-Associated Neuro-Ocular Syndrome","journal_title":"JAMA Ophthalmology","journal_issn":"2168-6165","published_at":"2026-04-30T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13133718/","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-06","doi":"10.1001/jamaophthalmol.2026.1054","days":"14","issn":"2168-6165","rank":"6","field":"Clinical Medicine","score":"11","category":"Ophthalmology","categories":["Ophthalmology"],"_categories":["Ophthalmology"]},"pubmed":{"doi":"10.1001/jamaophthalmol.2026.1054","title":"Different Predictors for Components of Spaceflight-Associated Neuro-Ocular 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Clinicians involved in astronaut health should consider these as distinct endpoints."}},{"doi":"10.1001/jamaophthalmol.2025.4635","pmid":"41264263","title":"Prediction of Optic Disc Edema Progression During Spaceflight","journal_title":"JAMA Ophthalmology","journal_issn":"2168-6165","published_at":"2025-11-20T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12635925/","source_score":25,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1001/jamaophthalmol.2025.4635","days":"7","issn":"2168-6165","rank":"5","field":"Clinical Medicine","score":"25","category":"Ophthalmology","categories":["Ophthalmology"],"_categories":["Ophthalmology"]},"pubmed":{"doi":"10.1001/jamaophthalmol.2025.4635","title":"Prediction of Optic Disc Edema Progression During Spaceflight.","journal":"JAMA ophthalmology","methods":"","results":"Data from 43 ISS crewmembers (mean [SD] age, 47 [7] years; 35 males [81%] and 8 females [19%]) with a mean (SD) flight duration of 198 (55) days were included. 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optic nerve head and surrounding structures in long-duration International Space Station astronauts.","journal-title":"JAMA Ophthalmol","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamaophthalmol.2022.5681","key":"eoi250072r7","year":"2023","issue":"2","author":"Ferguson","volume":"141","first-page":"168","unstructured":null,"article-title":"Incidence and progression of chorioretinal folds during long-duration spaceflight.","journal-title":"JAMA Ophthalmol","doi-asserted-by":"crossref"},{"DOI":"10.1152/japplphysiol.00211.2023","key":"eoi250072r8","year":"2024","issue":"4","author":"Christian","volume":"136","first-page":"753","unstructured":null,"article-title":"Development of optic disc edema during 30 days of hypercapnic head-down tilt bed rest is associated with short sleep duration and blunted temperature amplitude.","journal-title":"J Appl Physiol 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Ophthalmology"],"published-print":{"date-parts":[[2026,1,1]]},"reference-count":10,"published-online":null,"references-count":10,"short-container-title":["JAMA Ophthalmol"],"is-referenced-by-count":1},"unpaywall":{"doi":"10.1001/jamaophthalmol.2025.4635","is_oa":true,"title":"Prediction of Optic Disc Edema Progression During Spaceflight","updated":"2026-01-19T05:56:36+00:00","published_date":"2025-11-20","best_oa_location":{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12635925/","pmh_id":"oai:pubmedcentral.nih.gov:12635925","url_for_pdf":null,"url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12635925/"}}},"created_at":"2025-12-08T12:24:58.509Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"condition","value":"Optic Disc Edema","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"sample_size","value":"n=43","value_numeric":43},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"study_design","value":"Cohort Study","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"warning","value":"Data are from ~6‑month ISS missions; applicability to longer missions is not established in these data.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"warning","value":"Outcomes are OCT-based (ΔTRT) rather than clinical vision measures.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2025.4635","tag_type":"warning","value":"Risk estimates are reported at the eye level; person-level risk may differ.","value_numeric":null}],"summaries":{"what_studied":"A cohort of 43 International Space Station crewmembers was evaluated to see whether early in‑flight change in peripapillary total retinal thickness (ΔTRT) at flight day (FD) 30 predicts ΔTRT at FD150 during ~6‑month missions using OCT.","key_result":"FD30 ΔTRT strongly correlated with FD150 ΔTRT (r=0.89; 95% CI, 0.80–0.94; P<.001). Eyes with ΔTRT<20 μm at FD30 had a 2% risk (95% CI, 1%–15%) of ≥55 μm at FD150; an FD30 threshold >29 μm optimized risk discrimination, and FD30 ΔTRT of 20–55 μm or 29–55 μm carried 34% (95% CI, 19%–60%) and 58% (95% CI, 37%–90%) risk, respectively, of ≥55 μm at FD150.","practice_takeaway":"On long ISS missions, an eye with FD30 ΔTRT<20 μm is unlikely to develop clinically concerning ODE (≥55 μm) by FD150. Early in‑flight OCT can triage monitoring needs, with an FD30 cutpoint near 29 μm identifying higher‑risk eyes."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Optic Disc Edema"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Optic Disc Edema"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Optic Disc Edema"}}}]]

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