2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6f8,A hemodynamically significant patent ductus arteriosus (hsPDA) is common in preterm infants and may impact systemic and cerebral blood flow. This study explores Doppler flow patterns in systemic arteries including celiac artery/trunk (CeT), superior mesenteric artery (SMA) and middle cerebral artery (MCA) in preterm neonates with varying PDA shunt patterns, utilizing targeted neonatal echocardiography (TNE). Retrospective multicenter study of preterm infants (born <32 weeks gestation, <40 days of life) who underwent comprehensive TNE. Infants were categorized into 3 groups based on PDA shunt characteristics as follows: (1) No transductal shunt or trivial PDA with PDA score <6, (2) Left-to-right PDA (L-R PDA) and PDA score ≥8 and (3) Bidirectional PDA shunt with at least 10% of time spent right-to-left (R-L) and PDA score <6. In total, 86 patients with a median [IQR] gestational age of 26.1 weeks [23.8-27.7] weeks and birth weight of 767 [596, 1016] grams were included and classified into 3 groups: No PDA (n = 29), hsPDA (n = 48) and bidirectional PDA (n = 27). Abnormal systemic arterial Doppler patterns (absent or reversed diastolic flow in the Celiac artery) were present in 2 (5.7%), 15 (44.1%), and 1 (5.9%) of the patients in the no PDA, hsPDA, and bidirectional PDA groups respectively. Diastolic flow reversal in any of the systemic vessels evaluated was demonstrated only in the hsPDA group. This physiologic study demonstrates altered systemic Doppler patterns, which suggests a decreased ability to preserve lower body blood flow in premature infants with hsPDA. Further prospective studies are warranted to describe the association of these physiologic findings with clinical outcomes such as necrotizing enterocolitis. None (not applicable).31:Tb3b,Abstract Background A hemodynamically significant patent ductus arteriosus (hsPDA) is common in preterm infants and may impact systemic and cerebral blood flow. This study explores Doppler flow patterns in systemic arteries including celiac artery/trunk (CeT), superior mesenteric artery (SMA) and middle cerebral artery (MCA) in preterm neonates with varying PDA shunt patterns, utilizing targeted neonatal echocardiography (TNE). Methods Retrospective multicenter study of preterm infants (born <32 weeks gestation, <40 days of life) who underwent comprehensive TNE. Infants were categorized into 3 groups based on PDA shunt characteristics as follows: (1) No transductal shunt or trivial PDA with PDA score <6, (2) Left-to-right PDA (L-R PDA) and PDA score ≥8 and (3) Bidirectional PDA shunt with at least 10% of time spent right-to-left (R-L) and PDA score <6. Results In total, 86 patients with a median [IQR] gestational age of 26.1 weeks [23.8–27.7] weeks and birth weight of 767 [596, 1016] grams were included and classified into 3 groups: No PDA ( n = 29), hsPDA ( n = 48) and bidirectional PDA ( n = 27). Abnormal systemic arterial Doppler patterns (absent or reversed diastolic flow in the Celiac artery) were present in 2 (5.7%), 15 (44.1%), and 1 (5.9%) of the patients in the no PDA, hsPDA, and bidirectional PDA groups respectively. Diastolic flow reversal in any of the systemic vessels evaluated was demonstrated only in the hsPDA group. Conclusion This physiologic study demonstrates altered systemic Doppler patterns, which suggests a decreased ability to preserve lower body blood flow in premature infants with hsPDA. Further prospective studies are warranted to describe the association of these physiologic findings with clinical outcomes such as necrotizing enterocolitis. Clinical Trial Registration (if any) None (not applicable). 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Patent Ductus Arteriosus: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Patent Ductus Arteriosus (condition). Clinician-written summaries and actionable practice insights. 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Protocol deviation was only 1.9%, and 24% of infants in the SMART arm never needed treatment. The SMART strategy showed an 85% probability of a better Win ratio (1.34, 95% CrI 0.73–2.5) for survival without major morbidity vs. control.","limitations":"- Pilot trial — underpowered to confirm efficacy; the Win ratio CrI crosses 1.0, indicating uncertainty.\n- Open-label design may introduce performance bias.\n- 37% of eligible infants were not enrolled, limiting generalisability.","practice_takeaway":"Early echocardiographic screening and selective pharmacotherapy for moderate-severe PDA in infants <26 weeks GA appears feasible with minimal protocol deviation — about 1 in 4 screened infants avoided treatment entirely. A definitive RCT is warranted before changing routine practice."}},{"doi":"10.1038/s41372-025-02505-9","pmid":"41286416","title":"Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants","journal_title":"Journal of Perinatology","journal_issn":"0743-8346","published_at":"2025-11-25T00:00:00.000Z","url":"https://doi.org/10.1038/s41372-025-02505-9","source_score":19,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-29","doi":"10.1038/s41372-025-02505-9","days":"7","issn":"0743-8346","rank":"6","field":"Clinical Medicine","score":"19","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1038/s41372-025-02505-9","title":"Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.","journal":"Journal of perinatology : official journal of the California Perinatal Association","methods":"","results":"In total, 86 patients with a median [IQR] gestational age of 26.1 weeks [23.8-27.7] weeks and birth weight of 767 [596, 1016] grams were included and classified into 3 groups: No PDA (n = 29), hsPDA (n = 48) and bidirectional PDA (n = 27). Abnormal systemic arterial Doppler patterns (absent or reversed diastolic flow in the Celiac artery) were present in 2 (5.7%), 15 (44.1%), and 1 (5.9%) of the patients in the no PDA, hsPDA, and bidirectional PDA groups respectively. Diastolic flow reversal in any of the systemic vessels evaluated was demonstrated only in the hsPDA group.","abstract":"$30","keywords":[],"pubmed_id":"41286416","conclusions":"This physiologic study demonstrates altered systemic Doppler patterns, which suggests a decreased ability to preserve lower body blood flow in premature infants with hsPDA. Further prospective studies are warranted to describe the association of these physiologic findings with clinical outcomes such as necrotizing enterocolitis.","publication_date":"2025-11-25T00:00:00"},"crossref":{"DOI":"10.1038/s41372-025-02505-9","URL":"https://doi.org/10.1038/s41372-025-02505-9","ISSN":["0743-8346","1476-5543"],"link":[{"URL":"https://www.nature.com/articles/s41372-025-02505-9.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41372-025-02505-9","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41372-025-02505-9.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants"],"author":[{"given":"Joshua","family":"Mifflin","sequence":"first","affiliation":[]},{"given":"Marjorie","family":"Makoni","sequence":"additional","affiliation":[]},{"given":"Trassanee","family":"Chatmethakul","sequence":"additional","affiliation":[]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[]},{"given":"Adrianne R.","family":"Bischoff","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/100006545","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100006545","name":"U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities","award":["R25MD011564"],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100006108","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100006108","name":"U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences","award":["UM1TR004403"],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2025,11,24]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2025-11-24T09:03:34Z","timestamp":1763975014000,"date-parts":[[2025,11,24]]},"indexed":{"date-time":"2025-11-26T18:14:52Z","timestamp":1764180892991,"date-parts":[[2025,11,26]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000,"date-parts":[[2025,11,24]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000,"date-parts":[[2025,11,24]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41372-025-02505-9"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"15 April 2025"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"22 October 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"10 November 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"24 November 2025"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"The authors declare no competing interests."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"},"order":2,"value":"The studies involving humans were approved by the University of Oklahoma Health Sciences Center IRB (#14677) and the University of Iowa IRB (#202204622). 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Use systemic artery Doppler patterns to identify diastolic steal in hsPDA, but clinical outcome implications (e.g., NEC) were not evaluated."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Patent Ductus Arteriosus"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Patent Ductus Arteriosus"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Patent Ductus Arteriosus"}}}]]

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