2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T572,Daily molecular rhythms modulate skin physiology. However, the effects of chronic sun exposure on these rhythms remain unstudied. This study aimed to identify and compare rhythmic genes and pathways in photoprotected and chronically photoexposed human skin in vivo. Skin biopsies were taken from photoprotected (upper buttock) and photoexposed (dorsal forearm) skin of 20 subjects at noon, 6PM, midnight, and 6AM, across a 24-hour cycle, and gene expression was quantified with RNA sequencing. Cosinor analysis identified cycling genes along with their amplitudes and peak expression phases. We found that fewer genes met the criteria for cycling in the photoexposed skin as compared to the photoprotected skin, and transcripts that cycled in both sites had lower amplitudes and advanced peak times in photoexposed skin as compared to photoprotected skin. We identified 480 genes with significantly different rhythmic properties between the skin sites. Genes involved in DNA repair, MYC targets, E2F and G2M checkpoint pathways were enriched among those that showed higher amplitude oscillations in photoprotected skin. Genes involved in epithelial mesenchymal transition and apical junction pathways showed higher amplitude oscillations in photoexposed skin. These results suggest that chronic UV exposure may disrupt and/or reprogram circadian output rhythms to further alter skin physiology.31:T70f,Sunscreen use has known benefits, including decreasing the risk of developing skin cancer and photoaging. Previous studies have reported that the amount of sunscreen used decreased with increased unit price and that individuals underapply sunscreen. To assess how the cost of recommended sunscreen use varies depending on unit price and the other sun protective behaviors. In this economic evaluation study conducted from July 14 to August 31, 2025, sunscreen application costs were calculated based on recommended application amounts, use of other sun protection strategies, and 2025 sunscreen prices. The primary outcome was the annual cost of applying sunscreen based on recommended application amounts, use of other sun protection strategies, and 2025 sunscreen prices from an online retailer. For sunscreens with similar ingredients and sun protection factor ratings, the unit price of sunscreen varied by up to 17.5-fold across 3 sunscreens. Cost per application varied from $0.04 to $3.79 depending on wearing different combinations of typical clothing, whereas 1 year of sunscreen use was estimated to cost between $39.28 and $1429.42, a 36-fold difference, depending on unit price and other sun protective strategies used. A single week of sunscreen use at the beach, assuming 2 applications a day, costs approximately $6.57 to $135.82, depending on whether wearing shorts or a bikini and sunscreen unit price. These findings suggest that the cost of applying sunscreen at the recommended amounts varies significantly depending on unit price and the concurrent use of other sun protective strategies. Decreasing the potential cost by encouraging the use of other sun protective strategies and lower-priced sunscreens could facilitate compliance and reduction in the risk of developing skin cancers.32:Tb28, Importance Sunscreen use has known benefits, including decreasing the risk of developing skin cancer and photoaging. Previous studies have reported that the amount of sunscreen used decreased with increased unit price and that individuals underapply sunscreen. Objective To assess how the cost of recommended sunscreen use varies depending on unit price and the other sun protective behaviors. Design and Setting In this economic evaluation study conducted from July 14 to August 31, 2025, sunscreen application costs were calculated based on recommended application amounts, use of other sun protection strategies, and 2025 sunscreen prices. Main Outcomes and Measures The primary outcome was the annual cost of applying sunscreen based on recommended application amounts, use of other sun protection strategies, and 2025 sunscreen prices from an online retailer. Results For sunscreens with similar ingredients and sun protection factor ratings, the unit price of sunscreen varied by up to 17.5-fold across 3 sunscreens. Cost per application varied from $0.04 to $3.79 depending on wearing different combinations of typical clothing, whereas 1 year of sunscreen use was estimated to cost between $39.28 and $1429.42, a 36-fold difference, depending on unit price and other sun protective strategies used. A single week of sunscreen use at the beach, assuming 2 applications a day, costs approximately $6.57 to $135.82, depending on whether wearing shorts or a bikini and sunscreen unit price. Conclusions and Relevance These findings suggest that the cost of applying sunscreen at the recommended amounts varies significantly depending on unit price and the concurrent use of other sun protective strategies. Decreasing the potential cost by encouraging the use of other sun protective strategies and lower-priced sunscreens could facilitate compliance and reduction in the risk of developing skin cancers. 33:T6cd,Skin aging, characterized by wrinkles, pigment disorders, and enlarged pores, is driven primarily by photoaging. While a 1064 nm fractional picosecond laser shows efficacy in skin rejuvenation, comparative studies with intense pulsed light (IPL) remain limited. This randomized controlled trial (RCT) aimed to compare the efficacy and safety of the 1064 nm fractional picosecond laser with IPL in Asian women. In this single-center RCT, 38 Asian women (30-60 years) were randomized to receive 1064 nm Nd:YAG picosecond laser with a fractional optic (1064 nm Ps) (n = 19) or IPL (n = 19) therapy for three treatments. Baseline and post treatments Global Score for Photoaging (GSP), fine lines and pigmented spots scores were assessed by two blinded dermatologists based on VISIA photographs. Skin texture, T-zone pores and skin tone were measured with VISIA, C-Cube and Delfin Skin Color Catch. Transepidermal water loss (TEWL) was measured before and after a single treatment by Delfin Vapometer. All adverse events were documented. 1064 nm Ps outperformed IPL in the periorbital fine lines (p = 0.0315) and T-zone pore counts (p = 0.0473). GSP, infraorbital texture area, pigmented spots and lightness (L*), compared to baseline, significantly improved after treatments in each group, while there was no difference between two groups. Regarding safety, erythema was the most frequent transient response in both groups. Both 1064 nm fractional picosecond laser and IPL were effective and safe in treatments of facial rejuvenation. Compared to IPL, 1064 nm fractional picosecond laser excelled in periorbital fine lines and T-zone pores. This trial was registered at ClinicalTrials.gov (identifier: NCT07122310).34:Tca1,ABSTRACT Background and Objectives Skin aging, characterized by wrinkles, pigment disorders, and enlarged pores, is driven primarily by photoaging. While a 1064 nm fractional picosecond laser shows efficacy in skin rejuvenation, comparative studies with intense pulsed light (IPL) remain limited. This randomized controlled trial (RCT) aimed to compare the efficacy and safety of the 1064 nm fractional picosecond laser with IPL in Asian women. Methods In this single‐center RCT, 38 Asian women (30–60 years) were randomized to receive 1064 nm Nd:YAG picosecond laser with a fractional optic (1064 nm Ps) ( n = 19) or IPL ( n = 19) therapy for three treatments. Baseline and post treatments Global Score for Photoaging (GSP), fine lines and pigmented spots scores were assessed by two blinded dermatologists based on VISIA photographs. Skin texture, T‐zone pores and skin tone were measured with VISIA, C‐Cube and Delfin Skin Color Catch. Transepidermal water loss (TEWL) was measured before and after a single treatment by Delfin Vapometer. All adverse events were documented. Results 1064 nm Ps outperformed IPL in the periorbital fine lines ( p = 0.0315) and T‐zone pore counts ( p = 0.0473). GSP, infraorbital texture area, pigmented spots and lightness ( L *), compared to baseline, significantly improved after treatments in each group, while there was no difference between two groups. Regarding safety, erythema was the most frequent transient response in both groups. Conclusions Both 1064 nm fractional picosecond laser and IPL were effective and safe in treatments of facial rejuvenation. Compared to IPL, 1064 nm fractional picosecond laser excelled in periorbital fine lines and T‐zone pores. Clinical Trial Registration This trial was registered at ClinicalTrials.gov (identifier: NCT07122310). 35:T726,UV-A radiation contributes to photoaging/photocarcinogenesis by generating inflammation and oxidative damage. Current photoprotective strategies are limited by the availability/utilization of UV-A filters, highlighting an unmet need. Cannabidiol (CBD), having anti-inflammatory/antioxidant properties via regulation of nuclear erythroid 2-related factor, heme oxygenase 1, and peroxisome proliferator-activated receptor gamma, could potentially mitigate damage from UV-A exposure. This is a prospective, single-center, pilot clinical trial (NCT05279495). Nineteen participants applied nano-CBD (nCBD) or vehicle (VC) cream to randomized, blinded buttock sites twice daily for 14 days; then, the treated sites were irradiated with ≤3× UV-A minimal erythema dose. After 24 hours, punch biopsies were obtained for histology, immunohistochemistry, and real-time polymerase chain reaction. At 24 hours, 21% of participants had less observed erythema on CBD-treated skin than on VC skin. Histologically, nCBD-treated skin had reduced UV-A-induced epidermal hyperplasia than VC (P = .01). Immunohistochemistry detected reduced cytoplasmic/nuclear 8-oxoguanine glycosylase 1 staining in nCBD-treated skin compared with VC (P < .01). Quantitative mtDNA polymerase chain reaction demonstrated that UV-A-induced deletion of ND4 (proxy:4977 bp deletion; P = .003) and ND1 (proxy:3895 bp deletion; P = .002) was significantly reduced by in vivo nCBD treatment compared with VC. Small sample size is this study's limitation. Topically applied nCBD cream reduced UV-A-induced formation of a frequent mutagenic nuclear DNA base lesion and protected against mtDNA mutations associated with UV-A-induced skin aging. To our knowledge, this trial is the first to identify UV-protective capacity of CBD-containing topicals in humans.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Photoaging: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Photoaging (condition). Clinician-written summaries and actionable practice insights. 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Clinicians counseling patients on photoprotection may now cite circadian clock disruption as an additional mechanism of UV-mediated skin damage.","what_studied":"Compared circadian transcriptome rhythms between chronically photoexposed (dorsal forearm) and photoprotected (upper buttock) human skin in vivo, using RNA sequencing of biopsies from 20 subjects collected at 4 time points across a 24-hour cycle (noon, 6PM, midnight, 6AM).","key_result":"Photoexposed skin had fewer cycling genes, lower oscillation amplitudes, and phase-advanced peak expression times vs. photoprotected skin; 480 genes showed significantly different rhythmic properties between sites. DNA repair, MYC targets, E2F, and G2M checkpoint pathways showed higher amplitude oscillations in photoprotected skin, while epithelial-mesenchymal transition and apical junction pathways showed higher amplitudes in photoexposed skin.","limitations":"Small sample (n=20); only 4 time points across 24 hours may limit resolution of cosinor modeling; cross-sectional biopsy design cannot establish causality between UV exposure and clock disruption."}},{"doi":"10.1007/s00266-026-05834-y","pmid":"42047762","title":"Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review","journal_title":"Aesthetic Plastic Surgery","journal_issn":"0364-216X","published_at":"2026-04-28T00:00:00.000Z","url":"https://doi.org/10.1007/s00266-026-05834-y","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:49:32.722Z","updated_at":"2026-05-07T22:49:32.722Z","tags":[{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Atrophic Acne Scars","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Melasma","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Photoaging","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Primary Axillary Hyperhidrosis","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Skin Laxity","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Striae","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"generic","value":"botulinum toxin A","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Botulinum Toxin","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Fractional Laser","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Radiofrequency Microneedling","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"sample_size","value":"n=41 studies","value_numeric":41},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"study_design","value":"Systematic Review","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"Level of evidence is assigned as '2' based on systematic review of RCTs and cohort studies, but the journal's own assigned level was not explicitly stated in the provided text.","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"Sample size tag reflects number of included studies (n=41), not individual patients — total patient count is not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"The PROSPERO registration number (CRD420251089393) appears unusually formatted — may contain a typographic error in the source.","value_numeric":null}],"summaries":{"what_studied":"Systematic review evaluating the clinical effectiveness, safety, and patient-reported outcomes (PROs) of radiofrequency microneedling (RFMN) across multiple dermatological indications (acne scars, skin laxity/photoaging, rosacea, melasma, striae, axillary hyperhidrosis) in 41 studies published January 2015–July 2025.","key_result":"RFMN consistently reduced atrophic acne scar scores with efficacy comparable to fractional lasers, and improved wrinkle scales, dermal density, and submental volume for skin laxity/photoaging. Botulinum toxin A outperformed RFMN for primary axillary hyperhidrosis. Side effects were mostly transient (erythema, edema, pain); post-inflammatory hyperpigmentation was infrequent and self-limited. PROs showed high satisfaction and minimal downtime.","limitations":"- Heterogeneity in devices, technical parameters (temperature, pulse width, cooling), and outcome measures limits cross-study comparisons.\n- Inconsistent reporting of device settings prevents protocol standardization.\n- No meta-analysis performed; findings are narratively synthesized only.","practice_takeaway":"RFMN is a safe, well-tolerated option for atrophic acne scars, skin laxity, and photoaging across diverse Fitzpatrick skin types — consider it as a first-line or adjunct procedure with a favorable recovery profile. 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Outcomes included GSP, fine lines, pigmented spots, skin texture, T‑zone pores, skin tone, TEWL (pre/post one session), and adverse events, with two blinded dermatologists rating VISIA images.","key_result":"The picosecond laser improved periorbital fine lines versus IPL (p=0.0315) and reduced T-zone pore counts versus IPL (p=0.0473). Both groups improved from baseline in GSP, infraorbital texture area, pigmented spots, and lightness (L*), with no between-group differences; erythema was the most frequent transient response in both arms.","limitations":"Single-center, small sample (n=38) of Asian women limits generalizability. The abstract reports p-values without absolute effect sizes or follow-up duration.","practice_takeaway":"For Asian women seeking facial rejuvenation, a 1064 nm fractional picosecond Nd:YAG laser may yield better periorbital fine-line and T-zone pore outcomes than IPL, with similar gains in broader photoaging measures and transient erythema common. Either modality appeared effective and safe over the treatment course studied."}},{"doi":"10.1016/j.jaad.2024.06.088","pmid":"39025264","title":"Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A–induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study","journal_title":"Journal of the American Academy of Dermatology","journal_issn":"0190-9622","published_at":"2024-07-19T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaad.2024.06.088","source_score":63,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2024-08-19","doi":"10.1016/j.jaad.2024.06.088","days":"30","issn":"0190-9622","rank":"4","field":"Clinical Medicine","score":"63","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1016/j.jaad.2024.06.088","title":"Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study.","journal":"Journal of the American Academy of Dermatology","methods":"","results":"At 24 hours, 21% of participants had less observed erythema on CBD-treated skin than on VC skin. Histologically, nCBD-treated skin had reduced UV-A-induced epidermal hyperplasia than VC (P = .01). Immunohistochemistry detected reduced cytoplasmic/nuclear 8-oxoguanine glycosylase 1 staining in nCBD-treated skin compared with VC (P < .01). Quantitative mtDNA polymerase chain reaction demonstrated that UV-A-induced deletion of ND4 (proxy:4977 bp deletion; P = .003) and ND1 (proxy:3895 bp deletion; P = .002) was significantly reduced by in vivo nCBD treatment compared with VC.","abstract":"$35","keywords":["8-oxoguanine","UV-A","cannabidiol","cannabinoid","common deletion","mitochondrial DNA","mitochondrial mutation","photoaging","photodamage","photoprotection","reactive oxygen species"],"pubmed_id":"39025264","conclusions":"Topically applied nCBD cream reduced UV-A-induced formation of a frequent mutagenic nuclear DNA base lesion and protected against mtDNA mutations associated with UV-A-induced skin aging. 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Controlled Trial","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2024.06.088","tag_type":"warning","value":"Design is a small, single-center, split-body pilot with biomarker outcomes at 24 hours; clinical efficacy and durability are not established.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2024.06.088","tag_type":"warning","value":"Participant demographics and detailed dosing of UV-A beyond ≤3× minimal erythema dose are not provided in the abstract.","value_numeric":null}],"summaries":{"what_studied":"A prospective, single-center, pilot, split-body randomized trial tested nanoencapsulated cannabidiol (nCBD) cream versus vehicle on randomized, blinded buttock sites in 19 participants, applied twice daily for 14 days, then irradiated with ≤3× UV-A minimal erythema dose; biopsies were analyzed 24 hours later.","key_result":"At 24 hours, 21% of participants showed less erythema on nCBD-treated skin versus vehicle; nCBD reduced UV-A–induced epidermal hyperplasia (P=.01), lowered cytoplasmic/nuclear 8-oxoguanine glycosylase 1 staining (P<.01), and decreased mtDNA deletions (ND4 proxy 4977 bp, P=.003; ND1 proxy 3895 bp, P=.002) compared with vehicle.","limitations":"Very small, single-center pilot with short follow-up (24 hours) and surrogate biomarker outcomes rather than clinical endpoints; intraindividual split-body design may limit generalizability."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Photoaging"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Photoaging"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Photoaging"}}}]]

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